Hans Grönlund's research group

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Therapeutic Immune Design

We focus on diagnostics and curative treatments of chronic inflammatory diseases and cancer. Central to our research is the design and production of proteins for analyses of pathogenic antibodies and immune cells. The goal is to provide novel remedies applicable for clinical use. Therefore we adopt a translational research approach; we have established collaboration with clinicians, SciLife lab, biotechnical and medical companies, as well as academic research groups in Sweden and abroad. All our efforts aim to improve the quality of life for patients.

Gruppen Terapeutisk immundesign

Research projects

  • Autoantigens in multiple sclerosis (MS)
  • Allergenes as tools for diagnosis and treatment of allergic disease
  • Cancer immunotherapy

Read more about the research here

Selected publications

Evaluation of safety and efficacy as an adjuvant for the chitosan-based vaccine delivery vehicle ViscoGel in a single-blind randomised Phase I/IIa clinical trial.
Neimert-Andersson T, Binnmyr J, Enoksson M, Langebäck J, Zettergren L, Hällgren A, et al
Vaccine 2014 Oct;32(45):5967-74

Designing a multimer allergen for diagnosis and immunotherapy of dog allergic patients.
Nilsson O, Neimert-Andersson T, Bronge M, Grundström J, Sarma R, Uchtenhagen H, et al
PLoS ONE 2014 ;9(10):e111041

Dog saliva - an important source of dog allergens.
Polovic N, Wadén K, Binnmyr J, Hamsten C, Grönneberg R, Palmberg C, et al
Allergy 2013 ;68(5):585-92

Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse.
Nilsson O, Binnmyr J, Zoltowska A, Saarne T, van Hage M, Grönlund H
Allergy 2012 Jun;67(6):751-7

Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy.
Neimert-Andersson T, Thunberg S, Swedin L, Wiedermann U, Jacobsson-Ekman G, Dahlén S, et al
Allergy 2008 May;63(5):518-26

The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family.
Kaiser L, Grönlund H, Sandalova T, Ljunggren H, van Hage-Hamsten M, Achour A, et al
J. Biol. Chem. 2003 Sep;278(39):37730-5

The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT).
Valenta R, Lidholm J, Niederberger V, Hayek B, Kraft D, Grönlund H
Clin. Exp. Allergy 1999 Jul;29(7):896-904

Group members

Klara AsplundAssociated
Markus BackResearch technician
Mattias BrongePhD student, Graduate Student
Guro GafvelinSenior researcher
Hans GrönlundSenior researcher, Research team leader
Erik HolmgrenResearch coordinator
Klas JönssonAssociated
Andreas KaiserAssociated
Ola NilssonAssociated
Knut PetterssonAssociated
Claudia QueirozAssociated
Anna WhitemanPhD student, Graduate Student

Inflammation