Maria Genander's group
We are interested in understanding how stem cells are regulated to form a functional tissue during development and how these processes go wrong in i.e. cancer.
To generate a tissue and to restore its integrity after injury, tissues maintains self-renewing, long-term stem cells. Stem cells are defined by their ability to self-renew and to give rise to differentiated cell types that form the adult tissues. We are using the mouse skin as our main model system to define both intrinsic transcriptional programs and environmental signaling cues that are key for epidermal and hair follicle stem cell establishment and maintenance.
Using development as a roadmap, we want to understand how and if developmental signaling patterns are mimicked in tumor imitation and progression. Certain cutaneous tumors harbor a subpopulation of cells with tumor initiating capacities, thus acting as stem cells. We are interested in identifying characteristics that will allow for the specific targeting of these cells.
|David Grommisch||Graduate Student|
|Kim Vikhe Patil||Graduate Student|
|Maria Genander||Senior researcher|
|David Grommisch||Master student|
|Kim Vikhe Patil||Master student|
An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.
Sci Transl Med 2015 Apr;7(281):281ra44
BMP signaling and its pSMAD1/5 target genes differentially regulate hair follicle stem cell lineages.
Cell Stem Cell 2014 Nov;15(5):619-33
Ephrins negatively regulate cell proliferation in the epidermis and hair follicle.
Stem Cells 2010 Jul;28(7):1196-205
Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.
Cell 2009 Nov;139(4):679-92
EphB receptors coordinate migration and proliferation in the intestinal stem cell niche.
Cell 2006 Jun;125(6):1151-63