Jonas Frisén's Group
Stem Cells in Tissue Homeostasis and Regenerative Medicine
We are interested in the role of stem cells in cell turnover in healthy and pathological situations. We study the identity of stem cells and the organization of cellular lineages, the molecular regulation of cell production and the role of cell renewal in homeostasis and pathological situations. Many of our projects focus on stem cells in the brain and spinal cord and adult neurogenesis.
We are also interested in cell renewal in the heart and use the intestine as a stem cell and cancer model system. We have developed a method to study cell turnover by analyzing the integration of 14C derived from nuclear bomb tests in DNA, and use this to assess cell renewal in humans.
|Johanna Classon||PhD student, Graduate Student|
|Ilke Demirci||Research assistant|
|David Dias||Graduate Student|
|Sarantis Giatrellis||Research engineer|
|Joanna Hård||PhD student, Graduate Student|
|Ludvig Larsson||Research engineer|
|Helena Lönnqvist||Laboratory engineer|
|Jens Magnusson||PhD student, Graduate Student|
|Jeff Mold||Senior lab manager|
|Marta Paterlini||Senior researcher|
|Giuseppe Santopolo||PhD student, Graduate Student|
|Embla Steiner||PhD student, Graduate Student|
|Moa Stenudd||PhD student, Graduate Student|
|Margherita Zamboni||PhD student, Graduate Student|
A pericyte origin of spinal cord scar tissue.
Science 2011 Jul;333(6039):238-42
Origin of new glial cells in intact and injured adult spinal cord.
Cell Stem Cell 2010 Oct;7(4):470-82
Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.
Cell 2009 Nov;139(4):679-92
Evidence for cardiomyocyte renewal in humans.
Science 2009 Apr;324(5923):98-102
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.
Nat. Neurosci. 2009 Mar;12(3):259-67