Jonas Frisén's Group

Stem Cells in Tissue Homeostasis and Regenerative Medicine

We are interested in the role of stem cells in cell turnover in healthy and pathological situations. We study the identity of stem cells and the organization of cellular lineages, the molecular regulation of cell production and the role of cell renewal in homeostasis and pathological situations. Many of our projects focus on stem cells in the brain and spinal cord and adult neurogenesis.

We are also interested in cell renewal in the heart and use the intestine as a stem cell and cancer model system. We have developed a method to study cell turnover by analyzing the integration of 14C derived from nuclear bomb tests in DNA, and use this to assess cell renewal in humans.

Group Members

David DiasGraduate Student
Enric LlorensPostdoc
Evan GrahamPhD student
Giuseppe SantopoloGraduate Student
Hagen HuttnerGraduate Student
Helena LönnqvistLaboratory engineer
James ChellPostdoc
Jeff MoldPostdoc
Jens MagnussonPhD student, Graduate Student
Joanna HårdPhD student, Graduate Student
Johanna ClassonPhD student, Graduate Student
Jonas FrisénProfessor
Maggie YeungPhD student, Graduate Student
Marcelo ToroAssociated
Margherita ZamboniR&D trainee, Graduate Student
Marta PaterliniSenior researcher
Mehdi DjelloulPostdoc
Michael RatzPostdoc
Moa StenuddPhD student, Graduate Student
Patrik StåhlSenior lab manager
Pedro RéuPhD student, Graduate Student
Sarantis GiatrellisResearch engineer
Sofia ZdunekPhD student

Selected Publications

A pericyte origin of spinal cord scar tissue.
Göritz C, Dias D, Tomilin N, Barbacid M, Shupliakov O, Frisén J
Science 2011 Jul;333(6039):238-42

Origin of new glial cells in intact and injured adult spinal cord.
Barnabé-Heider F, Göritz C, Sabelström H, Takebayashi H, Pfrieger F, Meletis K, et al
Cell Stem Cell 2010 Oct;7(4):470-82

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.
Genander M, Halford M, Xu N, Eriksson M, Yu Z, Qiu Z, et al
Cell 2009 Nov;139(4):679-92

Evidence for cardiomyocyte renewal in humans.
Bergmann O, Bhardwaj R, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, et al
Science 2009 Apr;324(5923):98-102

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.
Carlén M, Meletis K, Göritz C, Darsalia V, Evergren E, Tanigaki K, et al
Nat. Neurosci. 2009 Mar;12(3):259-67

Developmental BiologyRegenerative MedicineStem Cell BiologyStem cells