Group Anna Färnert
Malaria: molecular epidemiology, immunity and interventions
The malaria parasite Plasmodium falciparum is highly polymorphic. The long time to acquire protective immunity may be due to the need to encounter a wide range of parasite variant. Maintenance of such immunity may also depend on persistence of multiclonal infections.
We aim to study the genetic diversity and dynamics of P. falciparum infections in childhood in different transmission settings. We will also assess how new control interventions, e.g. vaccine and intermittent preventive treatment, affect the diversity of infections and the risk of subsequent malaria. Moreover, we will investigate potential immunological mechanisms regulating the diversity of infections. The studies are performed in malaria endemic areas in Kenya, Ghana and Tanzania, as well as in Sweden in patients and immigrants.
Professor, MD, PhD
Anna Färnert, Professor, Head of Unit
Akua Botwe, PhD student
Peter Jahnmatz, PhD student
Muhammad Asghar, PhD, Post Doctoral fellow
Klara Sondén, MD, PhD, Post Doctoral Fellow
Manijeh Vafa Homann, PhD, Research Assistent Professor
Andreas Wångdahl, MD, PhD student
Katja Wyss, MD, PhD student
Victor Yman, MD, PhD student
Christopher Sundling, PhD, Research Assistent Professor
Obesity and Diabetes as Risk Factors for Severe Plasmodium falciparum Malaria: Results from a Swedish Nationwide Study.
Clin. Infect. Dis. 2017 May;():
High Rate of Treatment Failures in Nonimmune Travelers Treated With Artemether-Lumefantrine for Uncomplicated Plasmodium falciparum Malaria in Sweden: Retrospective Comparative Analysis of Effectiveness and Case Series.
Clin. Infect. Dis. 2017 Jan;64(2):199-206
Parallel telomere shortening in multiple body tissues owing to malaria infection.
Proc. Biol. Sci. 2016 Aug;283(1836):
Antibody acquisition models: A new tool for serological surveillance of malaria transmission intensity.
Sci Rep 2016 Feb;6():19472
Asymptomatic Multiclonal Plasmodium falciparum Infections Carried Through the Dry Season Predict Protection Against Subsequent Clinical Malaria.
J. Infect. Dis. 2015 Aug;212(4):608-16
Duration of residency in a non-endemic area and risk of severe malaria in African immigrants.
Clin. Microbiol. Infect. 2015 May;21(5):494-501
Chronic infection. Hidden costs of infection: chronic malaria accelerates telomere degradation and senescence in wild birds.
Science 2015 Jan;347(6220):436-8
High incidence of Plasmodium vivax malaria in newly arrived Eritrean refugees in Sweden since May 2014.
Euro Surveill. 2014 Sep;19(35):
Breadth of anti-merozoite antibody responses is associated with the genetic diversity of asymptomatic Plasmodium falciparum infections and protection against clinical malaria.
Clin. Infect. Dis. 2013 Nov;57(10):1409-16
Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers.
Eur. J. Immunol. 2013 Nov;43(11):2919-29
Bacterial coinfections in travelers with malaria: rationale for antibiotic therapy.
J. Clin. Microbiol. 2013 Jan;51(1):15-21
Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection.
J. Infect. Dis. 2009 Oct;200(7):1166-75
Plasmodium falciparum population dynamics: only snapshots in time?
Trends Parasitol. 2008 Aug;24(8):340-4
MD, PhD, Principal Investigator
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