Katja Petzold's profile page.
Please visit petzoldlab.com for more information.
Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.
How RNA move – excited states of RNA (Nature 2012):
|Transactvaton Response Element||Ribosomal A-site||Dimerization Initiation Site|
|January||the story of Petzold lab begins|
|July||first RNA is produced in the wet-lab|
|August||Postdoctorial Fellow Carolina Fontana joins the lab|
|September||Bruker delivers our new 600MHz NMR machine -work can begin|
|October||PhD student candidate Lorenzo Baronti joins the lab|
|October||Katja recieves the Ragnar Söderberg Fellowship in Medicine http://ragnarsoderbergsstiftelse.se/|
|November||Master student Oana Florean joins the lab|
|January||Lorenzo gets admitted to PhD studies at KI|
|January||PhD student candidate Hampus Karlsson and Master student Mona Farshchian are joining the lab|
|January||Nature article describing GU and GT mismatches was accepted|
|March||Postdoctoral Fellow Emilie Steiner is joining the lab|
|March||Our Nature paper is finally out, with a commentary on the impact on DNA|
|April||Postdoctoral Fellow Ileana Guzzetti is joining the lab. She will be working jointly with the E. Andersson Lab (KI-CMB)|
|April||Katja receives the Ingvar Carlsson Award|
Visualizing transient Watson-Crick-like mispairs in DNA and RNA duplexes.
Nature 2015 Mar;519(7543):315-20
Visualizing transient low-populated structures of RNA.
Nature 2012 Nov;491(7426):724-8
Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors.
Eur J Med Chem 2012 Nov;57():459-67
Semiconstant-time P,H-COSY NMR: analysis of complex mixtures of phospholipids originating from Helicobacter pylori.
J. Am. Chem. Soc. 2009 Oct;131(40):14150-1
EASY ROESY: reliable cross-peak integration in adiabatic symmetrized ROESY.
Chemistry 2009 ;15(3):585-8
Conserved nucleotides in an RNA essential for hepatitis B virus replication show distinct mobility patterns.
Nucleic Acids Res. 2007 ;35(20):6854-61
Applications for Master Students are welcome in the field of NMR or RNA biochemistry. Students have preferably a background in biochemistry, chemistry, molecular biology or physics with an interest in inter-disciplinary research.
We are always looking for talented Master, PhD students and Postdocs. Please send a 1 page coverletter, 2 page CV, publication record and list of references to katja.petzold'at'ki.se.
|Katja Petzold||Assistant Professor|
|Carolina Fontana||Postdoctoral Fellow|
|Emilie Steiner||Postdoctoral Fellow|
|Lorenzo Baronti||PhD student|
|Oana Florean||Master Student|
|Mona Farshchian||Master Student|
|Hampus Karlsson||PhD student Candidate|
|Ileana Guzzetti||Postdoctoral Fellow joined with the Andersson lab|