Petzold Group

Assistant Professor

Katja Petzold

Phone: 08-524 876 47
Organizational unit: Katja Petzold Group

Mobile: +46 070 588 17 96

Visiting address:

Room A2-424
Scheeles väg 2
Stockholm, 171 77

Katja Petzold's profile page.

Please visit for more information.


Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.

How RNA move – excited states of RNA (Nature 2012):



Transactvaton Response Element Ribosomal A-site Dimerization Initiation Site


January the story of Petzold lab begins
July first RNA is produced in the wet-lab
August Postdoctorial Fellow Carolina Fontana joins the lab
September Bruker delivers our new 600MHz NMR machine -work can begin
October PhD student candidate Lorenzo Baronti joins the lab
October Katja recieves the Ragnar Söderberg Fellowship in Medicine
November Master student Oana Florean joins the lab
January Lorenzo gets admitted to PhD studies at KI
January PhD student candidate Hampus Karlsson and Master student Mona Farshchian are joining the lab
January Nature article describing GU and GT mismatches was accepted
March Postdoctoral Fellow Emilie Steiner is joining the lab
March Our Nature paper is finally out, with a commentary on the impact on DNA
April Postdoctoral Fellow Ileana Guzzetti is joining the lab. She will be working jointly with the E. Andersson Lab (KI-CMB)
April Katja receives the Ingvar Carlsson Award

Selected Publications

Visualizing transient Watson-Crick-like mispairs in DNA and RNA duplexes.
Kimsey I, Petzold K, Sathyamoorthy B, Stein Z, Al-Hashimi H
Nature 2015 Mar;519(7543):315-20

Visualizing transient low-populated structures of RNA.
Dethoff E, Petzold K, Chugh J, Casiano-Negroni A, Al-Hashimi H
Nature 2012 Nov;491(7426):724-8

Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors.
Makatini M, Petzold K, Arvidsson P, Honarparvar B, Govender T, Maguire G, et al
Eur J Med Chem 2012 Nov;57():459-67

Semiconstant-time P,H-COSY NMR: analysis of complex mixtures of phospholipids originating from Helicobacter pylori.
Petzold K, Olofsson A, Arnqvist A, Gröbner G, Schleucher J
J. Am. Chem. Soc. 2009 Oct;131(40):14150-1

EASY ROESY: reliable cross-peak integration in adiabatic symmetrized ROESY.
Thiele C, Petzold K, Schleucher J
Chemistry 2009 ;15(3):585-8

Conserved nucleotides in an RNA essential for hepatitis B virus replication show distinct mobility patterns.
Petzold K, Duchardt E, Flodell S, Larsson G, Kidd-Ljunggren K, Wijmenga S, et al
Nucleic Acids Res. 2007 ;35(20):6854-61

Available Positions

Applications for Master Students are welcome in the field of NMR or RNA biochemistry. Students have preferably a background in biochemistry, chemistry, molecular biology or physics with an interest in inter-disciplinary research.

We are always looking for talented Master, PhD students and Postdocs. Please send a 1 page coverletter, 2 page CV, publication record and list of references to katja.petzold'at'

Research Group

Katja Petzold Assistant Professor
Carolina Fontana Postdoctoral Fellow
Emilie Steiner Postdoctoral Fellow
Lorenzo Baronti PhD student
Oana Florean Master Student
Mona Farshchian Master Student
Hampus Karlsson PhD student Candidate
Ileana Guzzetti Postdoctoral Fellow joined with the Andersson lab