Jan Hillert's research group

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Neurogenetics Multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system affecting around one million people world-wide. The disease progression varies between patients but often causes different degrees of disability.

In the MS group at CMM we aim to contribute to the urgently needed advancement of MS research by applying translational methods based on large patient cohorts. In this way hope to cast new light on the etiology of MS by seeking to understand the genetic components of the disease. We are also investigating a possible viral etiology of the disease using experimental systems.

MS treatments have improved significantly over the last decade, but they are still only partially effective and/or hampered by side effects, leaving a great clinical need for intensified research on disease mechanisms and novel therapeutics. Nab-lab, with team leader Anna Fogdell-Hahn, provides a service to neurologists by studying the development of antibodies against immunomodulatory biologic treatments. Thus, our research aims at fulfilling unmet needs of improved treatments in MS as well as adequate management of available treatments.

Research Projects

  •     Genetic analysis of multiple sclerosis
  •     Viral etiology of multiple sclerosis and epilepsy
  •     Anti-drug antibodies

Selected publications

No influence on disease progression of non-HLA susceptibility genes in MS.
Lundström W, Greiner E, Lundmark F, Westerlind H, Smestad C, Lorentzen A, et al
J. Neuroimmunol. 2011 Aug;237(1-2):98-100

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
, , Sawcer S, Hellenthal G, Pirinen M, Spencer C, et al
Nature 2011 Aug;476(7359):214-9

Purification of infectious human herpesvirus 6A virions and association of host cell proteins.
Hammarstedt M, Ahlqvist J, Jacobson S, Garoff H, Fogdell-Hahn A
Virol. J. 2007 ;4():101

Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallström E, Khademi M, et al
Nat. Genet. 2007 Sep;39(9):1108-13

Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections.
Donati D, Akhyani N, Fogdell-Hahn A, Cermelli C, Cassiani-Ingoni R, Vortmeyer A, et al
Neurology 2003 Nov;61(10):1405-11

Group members

Ali ManouchehriniaPostdoc
Anders BerglundAssociated
Andrius KavaliunasPostdoc
Anna GlaserProject manager
Christina SjöstrandAssociated
Eva LindströmAssociated
Firouz AmaniAssociated, Postdoc
Jan HillertResearch team leader, Professor/senior physician
Jenny LinkDatabase coordinator
Jonas Forsman Graduate Student
Jonatan FreilichPostdoc
Karin LyckeResearch nurse
Katarina FinkAssociated
Kerstin ImrellPostdoc
Konstantinos KostulasAssociated
Kristin SamuelssonGraduate Student
Leszek StawiarzGraduate Student, Project coordinator
Mabel CruzAssociated
Maria LantzGraduate Student
Omid BeikiAssociated, Postdoc
Rayomand PressAssociated
Sahl Khalid BedriPhD student
Sten FredriksonProfessor/senior physician
Susanne MalmbergAssociated
Sven PålhagenAssociated
Tim SpelmanAssistant professor
Tor AnsvedAssociated
Ulrik Nilsson RantaGraduate Student
Virginija Danylaité KarrenbauerAssociated