Jan Hillert´s research group
Neurogenetics Multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system affecting around one million people world-wide. The disease progression varies between patients but often causes different degrees of disability.
In the MS group at CMM we aim to contribute to the urgently needed advancement of MS research by applying translational methods based on large patient cohorts. In this way hope to cast new light on the etiology of MS by seeking to understand the genetic components of the disease. We are also investigating a possible viral etiology of the disease using experimental systems.
MS treatments have improved significantly over the last decade, but they are still only partially effective and/or hampered by side effects, leaving a great clinical need for intensified research on disease mechanisms and novel therapeutics. Nab-lab, with team leader Anna Fogdell-Hahn, provides a service to neurologists by studying the development of antibodies against immunomodulatory biologic treatments. Thus, our research aims at fulfilling unmet needs of improved treatments in MS as well as adequate management of available treatments.
- Genetic analysis of multiple sclerosis
- Viral etiology of multiple sclerosis and epilepsy
- Anti-drug antibodies
No influence on disease progression of non-HLA susceptibility genes in MS.
J. Neuroimmunol. 2011 Aug;237(1-2):98-100
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Nature 2011 Aug;476(7359):214-9
Purification of infectious human herpesvirus 6A virions and association of host cell proteins.
Virol. J. 2007 ;4():101
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
Nat. Genet. 2007 Sep;39(9):1108-13
Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections.
Neurology 2003 Nov;61(10):1405-11
|Sahl Khalid Bedri||Doktorand|
|Virginija Danylaité Karrenbauer||Anknuten|
|Jonas Forsman Benhalima||Forskarstuderande|
|Ulrik Nilsson Ranta||Forskarstuderande|