Jan Hillert's research group

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Neurogenetics Multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system affecting around one million people world-wide. The disease progression varies between patients but often causes different degrees of disability.

In the MS group at CMM we aim to contribute to the urgently needed advancement of MS research by applying translational methods based on large patient cohorts. In this way hope to cast new light on the etiology of MS by seeking to understand the genetic components of the disease. We are also investigating a possible viral etiology of the disease using experimental systems.

MS treatments have improved significantly over the last decade, but they are still only partially effective and/or hampered by side effects, leaving a great clinical need for intensified research on disease mechanisms and novel therapeutics. Nab-lab, with team leader Anna Fogdell-Hahn, provides a service to neurologists by studying the development of antibodies against immunomodulatory biologic treatments. Thus, our research aims at fulfilling unmet needs of improved treatments in MS as well as adequate management of available treatments.

Research Projects

  •     Genetic analysis of multiple sclerosis
  •     Viral etiology of multiple sclerosis and epilepsy
  •     Anti-drug antibodies

Selected publications

No influence on disease progression of non-HLA susceptibility genes in MS.
Lundström W, Greiner E, Lundmark F, Westerlind H, Smestad C, Lorentzen A, et al
J. Neuroimmunol. 2011 Aug;237(1-2):98-100

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
, , Sawcer S, Hellenthal G, Pirinen M, Spencer C, et al
Nature 2011 Aug;476(7359):214-9

Purification of infectious human herpesvirus 6A virions and association of host cell proteins.
Hammarstedt M, Ahlqvist J, Jacobson S, Garoff H, Fogdell-Hahn A
Virol. J. 2007 Oct;4():101

Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallström E, Khademi M, et al
Nat. Genet. 2007 Sep;39(9):1108-13

Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections.
Donati D, Akhyani N, Fogdell-Hahn A, Cermelli C, Cassiani-Ingoni R, Vortmeyer A, et al
Neurology 2003 Nov;61(10):1405-11

Group members

Sahl Khalid BedriPhD student
Omid BeikiAssociated, Postdoc
Mabel CruzAssociated
Virginija Danylaité KarrenbauerAssociated
Björn EvertssonAssociated
Katarina FinkAssociated
Jonas Forsman Graduate Student
Sten FredriksonProfessor/senior physician
Anna GlaserProject manager
Jan HillertResearch team leader, Professor/senior physician
Kerstin ImrellAssociated
Eva-Carin JacobssonAssociated
Andrius KavaliunasPostdoc
Konstantinos KostulasAssociated
Maria LantzAssociated, Postdoc
Eva LindströmAssociated
Jenny LinkDatabase coordinator
Karin LyckeResearch nurse
Ali ManouchehriniaPostdoc
Ulrik Nilsson RantaGraduate Student
Rayomand PressAssociated
Sven PålhagenAssociated
Ryan RamanujamPostdoc
Kristin SamuelssonGraduate Student
Christina SjöstrandAssociated
Tim SpelmanAssistant professor
Leszek StawiarzGraduate Student, Project coordinator