Jan Hillert´s research group

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Neurogenetics Multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system affecting around one million people world-wide. The disease progression varies between patients but often causes different degrees of disability.

In the MS group at CMM we aim to contribute to the urgently needed advancement of MS research by applying translational methods based on large patient cohorts. In this way hope to cast new light on the etiology of MS by seeking to understand the genetic components of the disease. We are also investigating a possible viral etiology of the disease using experimental systems.

MS treatments have improved significantly over the last decade, but they are still only partially effective and/or hampered by side effects, leaving a great clinical need for intensified research on disease mechanisms and novel therapeutics. Nab-lab, with team leader Anna Fogdell-Hahn, provides a service to neurologists by studying the development of antibodies against immunomodulatory biologic treatments. Thus, our research aims at fulfilling unmet needs of improved treatments in MS as well as adequate management of available treatments.

Research Projects

  •     Genetic analysis of multiple sclerosis
  •     Viral etiology of multiple sclerosis and epilepsy
  •     Anti-drug antibodies

Selected publications

No influence on disease progression of non-HLA susceptibility genes in MS.
Lundström W, Greiner E, Lundmark F, Westerlind H, Smestad C, Lorentzen A, et al
J. Neuroimmunol. 2011 Aug;237(1-2):98-100

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
, , Sawcer S, Hellenthal G, Pirinen M, Spencer C, et al
Nature 2011 Aug;476(7359):214-9

Purification of infectious human herpesvirus 6A virions and association of host cell proteins.
Hammarstedt M, Ahlqvist J, Jacobson S, Garoff H, Fogdell-Hahn A
Virol. J. 2007 ;4():101

Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallström E, Khademi M, et al
Nat. Genet. 2007 Sep;39(9):1108-13

Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections.
Donati D, Akhyani N, Fogdell-Hahn A, Cermelli C, Cassiani-Ingoni R, Vortmeyer A, et al
Neurology 2003 Nov;61(10):1405-11

Group members

Tor AnsvedAnknuten
Sahl Khalid BedriDoktorand
Omid BeikiPostdoc
Mabel CruzAnknuten
Virginija Danylaité KarrenbauerAnknuten
Katarina FinkAnknuten
Jonas Forsman BenhalimaForskarstuderande
Sten FredriksonProfessor/överläkare
Anna GlaserProjektledare
Jan HillertForskargruppsledare
Jan HillertProfessor/överläkare
Kerstin ImrellPostdoc
Andrius KavaliunasPostdoc
Konstantinos KostulasAnknuten
Maria LantzForskarstuderande
Eva LindströmAnknuten
Karin LyckeForskningssköterska
Susanne MalmbergAdministratör
Ali ManouchehriniaPostdoc
Thomas MastermanAnknuten
Ulrik Nilsson RantaForskarstuderande
Rayomand PressAnknuten
Sven PålhagenAnknuten
Ryan RamanujamAnknuten
Ryan RamanujamPostdoc
Kristin SamuelssonForskarstuderande
Christina SjöstrandAnknuten
Leszek StawiarzForskarstuderande
Leszek StawiarzProjektsamordnare

Inflammation