US research funding at KI

US and international funding supports many research projects at Karolinska Institutet (KI). In 2019, almost SEK 100 million was obtained from US federal agencies, including the National Institutes of Health (NIH), and US private foundations.

Funding 2010 – 2019 (amount in million SEK)
Year Government agencies Private foundations Total
2010 45,9 22 70,9
2011 22,6 22,1 43,7
2012 25,2 33,1 58,3
2013 21,3 45,6 66,9
2014 22,5 46,1 68,6
2015 32,8 42,4 75,2
2016 40,6 38,2 78,8
2017 41,3 32,3 73,6
2018 50,0 45,0 95,0
2019 52,1 44,5 96,6

US federal PI-initiated research grants

NIH - 2020

  • Lars Terenius (R01/Prime) - Drug targeting the dynamics of opioid systems in alcohol dependence
  • Anna Marseglia (R24/Sub) - Developing a biological marker of cognitive reserve with deep learning from multimodal structural MRI
  • Nina Bohm-Starke (R21/Sub) - Risk of vulvodynia due to immune-related health events throughout the life course
  • Yi Lu (R01/Sub) - A Trans-Nordic Study of Extreme Major Depression
  • Sarah Bergen (R01/Prime) – A comparison of environmental and genetic risks for schizophrenia and bipolar disorder: A Swedish national study
  • Ivan Nalvarte (R01/Prime) - Understanding the role of menopause and estrogen receptor activation for Alzheimer's disease risk
  • Elizabeth Arkema (R01/Sub) - Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?

NIH – 2019

  • Sara Öberg (R01/Sub) - Maternal use of prescribed opioid analgesics and risk of adverse offspring outcomes
  • Gunilla Karlsson Hedestam (P51/Sub) - Support of Yerkes National Primate Research Center
    Karl Eriksson (U01/Sub) - STABILITY 2: ACL Reconstruction +/- Lateral Tenodesis with Patellar vs. Quad Tendon
  • Sven Cnattingius (R21/Sub) - Prenatal and Neonatal Risk Factors for Adverse Neurodevelopmental Outcomes in Childhood and Early Adulthood
  • Gunilla Karlsson Hedestam (UM1/Sub) - Consortium for HIV/AIDS Vaccine Development
  • Cecilia Magnusson (R01/Sub) - Maternal epilepsy, antiepileptic drug use during pregnancy, and risk of autism
  • Benjamin Murrell (UM1/Sub) - HVTN Laboratory Center

NIH – 2018

  • Sarah Bergen (R21/Prime) – Schizophrenia Comorbidities: Common Genes and Clusters

NIH – 2017

  • Sara Öberg (R01/Sub) - Long-term Impact of Fertility Treatment Study
  • Johan Grunewald (R01/Sub) – T cell epitopes in sarcoidosis
  • Rickard Sandberg (R01/Sub) – Deciphering the building blocks of hippocampal circuits
  • Maria Sabater Lleal (R01/Sub) – Population genomic variation, functional biology, and the risk of venous thrombosis
  • Rickard Sandberg (U19/Sub) – A comprehensive whole-brain atlas of cell types in the mouse
  • Sten Linnarsson (U01/Sub) – A multimodal atlas of human brain cell types
  • Barbara Canlon (R56/Prime) – Circadian regulation of glucocorticoid-dependent inflammation in noise-induced synaptopathy
  • Michael Yi Bonner (F31/Prime) – Redox modulation - Impact on Tumor Growth and Therapeutic Anticancer Efficacy
  • Ivanka Savic-Berglund (R01/Sub) – Gender identity and own body perception implications for the neurobiology of gender dysphoria
  • Gunilla Karlsson Hedestam (U01/Sub) – Immunoglobulin gene diversity in an African population and impact on antibody function in HIV infection

NIH – 2016

  • Ahmed Elewa (F32/Prime) – Discovering signature genes and developing expression markers for blastema cells
  • David Mataix-Cols (R01/Sub) – OCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment Mechanisms.
  • Elias Arnér (R21/Sub) - Redox regulation in the hepatostat.
  • Fredrik Wiklund (R01/Sub) – The Genetic Basis of Aggressive Prostate Cancer: The Role of Rare Variation.
  • Konstantinos Meletis (R21/Sub) – Development of a whole-brain cellular mapping approach in a genetic model of autism and intellectual disability.
  • Nancy Pedersen (R56/Sub) – Gene-Environment Interplay of Social contexts and Aging-Related Outcomes.
  • Ujjwal Neogi (R01/Sub) – Reverse Transcriptase Multi-Class Drug Resistance and Rilpivirine Susceptibility in Diverse HIV-1 Subtypes.

NIH – 2015

  • Johan Sandberg (R01/Sub) – Intestinal MAIT Cells in HIV Infection.
  • Karin Broberg (R01/Sub) – Factors modifying the toxicity of methylmercury in a fish-eating population.
  • Kristina Gemzell Danielsson (Federal contract/Sub) – Clinical evaluation of nestorone gel and testosterone gel for male contraception.
  • Martin Neovius (R01/Sub) – Benefits, Risks & Costs of Bariatric Surgery: Register-Enriched Cohort Studies.
  • Mikael Landén (R01/Sub) – 1/3 Genetic analysis of the international cohort collection for bipolar disorder.
  • Marianne Schultzberg (R21/Sub) – Resolving Factors in Alzheimers Disease.

Department of Defense (DoD)

2020 - Samir EL Andaloussi (CDMRP/Prime) - Muscle-Targeted Cell-Penetrating Peptides for Delivery of Cas9-RNPs and Modified mRNA to Dystrophic Muscle

2017: Helena Ledmyr (Office of Naval Research) – CSP – The 10th Neuroinformatics Congress of the International Neuroinformatics Coordinating Facility (INCF)

2016: Barbara Canlon (CDMRP/Prime) – Chronopharmacological Interventions for the Successful Treatment of Noise-Induced Hearing Loss

2015: Theresa Vincent (CDMRP/Sub) – Targeting Breast Cancer Metastasis through Selective Inhibition of RNA Polymerase I

Major private foundation PI-initiated research grants

Bill & Melinda Gates Foundation

2020

Karin Loré (Prime) - COVID-19: NHP Study of Novavax nanoparticle at Karolinska

Anna Smed Sörensen – (Prime) - COVID-19: blood and airway disease in Sweden

Karin Loré (Prime) -  Immunogenicity study of CureVac’s mRNA vaccine for Covid-19 in rhesus macaques

2018

Bill & Melinda Gates Foundation:

Karin Loré (Prime) – Analyse the immune responses elicited by novel mRNA-based vaccines. More reading at the staff portal

2017

Bill & Melinda Gates Foundation: Karin Loré (Sub) – Structure Based Immunogen Design at UWIPD.

2016

Jeffrey Modell Foundation: Lennart Hammarström (Sub)

Patient-Centered Outcomes Research Institute (PCORI): Fredrik Piehl (Prime) – Rituximab in Multiple Sclerosis: A Comparative Study on Effectiveness, Safety, and Patient-Reported Outcomes. Read a news article on KI News

2015

Bill & Melinda Gates Foundation:

CHDI Foundation Inc: Christer Halldin

The Myositis Association: Ingrid Lundberg

The Vallee Foundation: Rickard Sandberg (Vallee Scholar) – The nature of allelic gene expression in vivo.