Lu Yi

Lu Yi

Senior Forskare
E-postadress: lu.yi@ki.se
Telefon: +46852487772
Besöksadress: Nobelsvägen 12a, 17165 SOLNA
Postadress: C8 Medicinsk epidemiologi och biostatistik, C8 MEB I Lu, 171 77 Stockholm
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Artiklar

  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: GLOBAL. 2025;4(4):100519
    Smew AI; Gong T; Kuja-Halkola R; Lundholm C; Harder A; Lu Y; Savendahl L; Lichtenstein P; Brew BK; Almqvist C
  • Article: NATURE GENETICS. 2025;57(10):2427-2435
    van der Laan CM; Ip HF; Schipper M; Hottenga J-J; St Pourcain B; Zayats T; Pool R; Krapohl EML; Brikell I; Soler Artigas M; Cabana-Domínguez J; Llonga N; Nolte IM; Bolhuis K; Palviainen T; Zafarmand H; Gordon S; Aliev F; Burt SA; Wang CA; Saunders G; Karhunen V; Adkins DE; Border R; Peterson RE; Prinz JA; Thiering E; Vilor-Tejedor N; Ahluwalia TS; Allegrini A; Rimfeld K; Chen Q; Lu Y; Martin J; Bosch R; Ramos-Quiroga JA; Neumann A; Ensink J; Grasby KL; Morosoli JJ; Tong X; Marrington S; Scott JG; Shabalin AA; Corley R; Evans LM; Sugden K; Alemany S; Sass L; Vinding R; Ehli EA; Hagenbeek FA; Derks EM; Larsson H; Snieder H; Cecil C; Whipp AM; Korhonen T; Vuoksimaa E; Rose RJ; Uitterlinden AG; Haavik J; Harris JR; Helgeland Ø; Johansson S; Knudsen GPS; Njolstad PR; Lu Q; Rodriguez A; Henders AK; Mamun A; Najman JM; Brown S; Hopfer C; Krauter K; Reynolds CA; Smolen A; Stallings M; Wadsworth S; Wall TL; Eaves L; Silberg JL; Miller A; Havdahl A; Llop S; Lopez-Espinosa M-J; Bønnelykke K; Sunyer J; Arseneault L; Standl M; Heinrich J; Boden J; Pearson J; Horwood J; Kennedy M; Poulton R; Maes HH; Hewitt J; Copeland WE; Middeldorp CM; Williams GM; Wray N; Järvelin M-R; McGue M; Iacono W; Caspi A; Moffitt TE; Whitehouse AJO; Pennell CE; Klump KL; Jiang C; Dick DM; Reichborn-Kjennerud T; Martin NG; Medland SE; Vrijkotte T; Kaprio J; Tiemeier H; Davey Smith G; Hartman CA; Oldehinkel AJ; Casas M; Ribasés M; Lichtenstein P; Lundström S; Plomin R; Bartels M; Nivard MG; Boomsma DI
  • Article: MOLECULAR PSYCHIATRY. 2025;:1-9
    Brann E; Guintivano J; Yang Y; Lundborg L; Opatowski M; Fang F; Valdimarsdottir UA; Fransson E; Skalkidou A; Lu Y; Lu D
  • Article: MOLECULAR PSYCHIATRY. 2025;:1-8
    Haram M; Jangmo A; Jaholkowski P; Pasman J; Meijsen J; Shorter JR; Corfield EC; Frei O; Reichborn-Kjennerud T; Buil A; Lu Y; Werge T; Sullivan P; Andreassen OA; Tesli M
  • Article: ANNALS OF NEUROLOGY. 2025
    Manouchehrinia A; Fitzgerald KC; Salter A; Marrie RA; Alfredsson L; Bernstein CN; Bolton JM; Cutter G; Fisk JD; Graff LA; Hitchon CA; Hillert J; Kockum I; Lu Y; Lublin FD; McKay K; Olsson T; Patten S; Patki A; Riel H; Shchetynsky K; Stridh P; Tiwari HK; Wolinsky JS; Kowalec K
  • Article: MOLECULAR PSYCHIATRY. 2025;:5024-5033
    Xiong Y; Krebs K; Jermy B; Karlsson R; Pasman JA; Nguyen T-D; Gong T; Kowalec K; Ruck C; Sigstrom R; Jonsson L; Clements CC; Horbeck E; Andersson E; Backman J; Ganna A; German J; Sullivan PF; Landen M; Lehto K; Lu Y
  • Article: BMJ MEDICINE. 2025;4(1):e001129
    Hu K; Nguyen T-D; Borges K; Kuja-Halkola R; Butwicka A; Brikell I; Crowley JJ; Chang Z; D'Onofrio BM; Larsson H; Lichtenstein P; Rueck C; Bulik C; Sullivan P; Fang F; Lu Y
  • Article: BMC PSYCHIATRY. 2025;25(1):532
    Berthold N; MacDermod CM; Thornton LM; Parker R; Morales SAC; Hog L; Kennedy HL; Guintivano J; Sullivan PF; Crowley JJ; Johnson JS; Birgegard A; Fundin BT; Frans E; Xu J; Pukenga MPN; Miller AL; Aguilar MV; Barakat S; Abdulkadir M; White JP; Larsen JT; Trujillo E; Winterman B; Zhang R; Lawson R; Wonderlich S; Wonderlich J; Schaefer LM; Mehler PS; Oakes J; Foster M; Gaudiani J; Vacuan ETC; Compte EJ; Petersen LV; Yilmaz Z; Micali N; Jordan J; Kennedy MA; Maguire S; Huckins LM; Lu Y; Dinkler L; Martin NG; Bulik CM
  • Article: CELL. 2025;188(3):640-652.e9
    Mcintosh AM; Lewis CM; Adams MJ; Streit F; Meng X; Awasthi S; Adey BN; Choi KW; Chundru VK; Coleman JRI; Ferwerda B; Foo JC; Gerring ZF; Giannakopoulou O; Gupta P; Hall ASM; Harder A; Howard DM; Hubel C; Kwong ASF; Levey DF; Mitchell BL; Ni G; Ota VK; Pain O; Pathak GA; Schulte EC; Shen X; Thorp JG; Walker A; Yao S; Zeng J; Zvrskovec J; Aarsland D; Actkins KV; Adli M; Agerbo E; Aichholzer M; Aiello A; Air TM; Als TD; Andersson E; Andlauer TFM; Arolt V; Ask H; Backman J; Badola S; Ballard C; Banasik K; Bass NJ; Beekman ATF; Belangero S; Bigdeli TB; Binder EB; Bjerkeset O; Bjornsdottir G; Borte S; Brann E; Braun A; Brodersen T; Bruckl TM; Brunak S; Bruun MT; Burmeister M; Buspavanich P; Bybjerg-Grauholm J; Byrne EM; Cai J; Campbell A; Campbell ML; Campos AI; Castelao E; Cervilla J; Chaumette B; Chen C-Y; Chen H-C; Chen Z; Cichon S; Colodro-Conde L; Corbett A; Corfield EC; Couvy-Duchesne B; Craddock N; Dannlowski U; Davies G; de Geus EJC; Deary IJ; Degenhardt F; Dehghan A; DePaulo JR; Deuschle M; Didriksen M; Dinh KM; Direk N; Djurovic S; Docherty AR; Domschke K; Dowsett J; Drange OK; Dunn EC; Eaton W; Einarsson G; Eley TC; Elsheikh SSM; Engelmann J; Benros ME; Erikstrup C; Escott-Price V; Fabbri C; Fang Y; Finer S; Frank J; Free RC; Gallo L; Gao H; Gill M; Gilles M; Goes FS; Gordon SD; Grove J; Gudbjartsson DF; Gutierrez B; Hahn T; Hall LS; Hansen TF; Haraldsson M; Hartman CA; Havdahl A; Hayward C; Heilmann-Heimbach S; Herms S; Hickie IB; Hjalgrim H; Hjerling-Leffler J; Hoffmann P; Homuth G; Horn C; Hottenga J-J; Hougaard DM; Hovatta I; Huang QQ; Hucks D; Huider F; Hunt KA; Ialongo NS; Ising M; Isometsa E; Jansen R; Jiang Y; Jones I; Jones LA; Jonsson L; Kanai M; Karlsson R; Kasper S; Kendler KS; Kessler RC; Kloiber S; Knowles JA; Koen N; Kraft J; Kranzler HR; Krebs K; Kallak TK; Kutalik Z; Lahtela E; Lake M; Larsen MH; Lenze EJ; Lewins M; Lewis G; Li L; Danae B; Lin K; Lind PA; Liu Y-L; MacIntyre DJ; MacKinnon DF; Maher BS; Maier W; Marshe VS; Martinez-Levy GA; Matsuda K; Mbarek H; McGuffin P; Medland SE; Meinert S; Mikkelsen C; Mikkelsen S; Milaneschi Y; Millwood IY; Molina E; Mondimore FM; Mortensen PB; Mulsant BH; Naamanka J; Najman JM; Nauck M; Nenadic I; Nielsen KR; Nolte IM; Nordentoft M; Nothen MM; Nyegaard M; O'Donovan MC; Oddsson A; Oliveira AM; Olsen CM; Oskarsson H; Ostrowski SR; Owen MJ; Packer R; Palviainen T; Pan PM; Pato CN; Pato MT; Pedersen NL; Pedersen OB; Peyrot WJ; Potash JB; Preisig M; Preuss MH; Quiroz JA; Renteria ME; Reynolds CFIII; Rice JP; Sakaue S; Santoro ML; Schoevers RA; Schork A; Schulze TG; Send TS; Shi J; Sigurdsson E; Singh K; Sinnamon GCB; Sirignano L; Smeland OB; Smith DJ; Sofer T; Sorensen E; Srinivasan S; Stefansson H; Stefansson K; Straub P; Su M-H; Tadic A; Teismann H; Teumer A; Thapar A; Thomson PA; Thomson PA; Topaloudi A; Tsai S-J; Tzoulaki I; Uhl G; Uitterlinden AG; Ullum H; Umbricht D; Ursano RJ; Van der Auwera S; van Hemert AM; Veluchamy A; Viktorin A; Volzke H; Walters GB; Wang X; Wani A; Weissman MM; Wellmann J; Whiteman DC; Wildman D; Willemsen G; Williams AT; Winsvold BS; Witt SH; Xiong Y; Zillich L; Zwart J-A; Andreassen OA; Baune BT; Berger K; Boomsma DI; Borglum AD; Breen G; Cai N; Coon H; Copeland WE; Creese B; Cruz-Fuentes CS; Czamara D; Davis LK; Derks EM; Domenici E; Elliott P; Forstner AJ; Gawlik M; Gelernter J; Grabe HJ; Hamilton SP; Hveem K; John C; Kaprio J; Kircher T; Krebs M-O; Kuo P-H; Landen M; Lehto K; Levinson DF; Li QS; Lieb K; Loos RJF; Lu Y; Lucae S; Luykx JJ; Maes HHM; Magnusson PK; Martin HC; Martin NG; McQuillin A; Middeldorp CM; Milani L; Mors O; Muller DJ; Muller-Myhsok B; Okada Y; Oldehinkel AJ; Paciga SA; Palmer CNA; Paschou P; Penninx BWJH; Perlis RH; Peterson RE; Pistis G; Polimanti R; Porteous DJ; Posthuma D; Rabinowitz JA; Reichborn-Kjennerud T; Reif A; Rice F; Ricken R; Rietschel M; Rivera M; Ruck C; Salum GA; Schaefer C; Sen S; Serretti A; Skalkidou A; Smoller JW; Stein DJ; Stein F; Stein MB; Sullivan PF; Tesli M; Thorgeirsson TE; Tiemeier H; Timpson NJ; Uddin M; Uher R; van Hee DA; Verweij KJH; Walters RG; Wassertheil-Smoller S; Wendland JR; Werge T; Zwinderman AH; Kuchenbaecker K; Wray NR; Ripke S; Lewis CM; McIntosh AM
  • Article: EBIOMEDICINE. 2025;112:105576
    Nguyen T-D; Meijsen JJ; Sigstroem R; Kuja-Halkola R; Xiong Y; Harder A; Kowalec K; Pasman JA; Scarpa C; Horbeck E; Jonsson L; Hagg S; Mullins N; O'Connell KS; Dalman C; Helenius D; Zetterberg R; Larsson H; Lichtenstein P; Andreassen OA; Werge T; Buil A; Landen M; Sullivan PF; Lu Y
  • Article: NATURE COMMUNICATIONS. 2025;16(1):395
    Yao S; Harder A; Darki F; Chang Y-W; Li A; Nikouei K; Volpe G; Lundstroem JN; Zeng J; Wray NR; Lu Y; Sullivan PF; Hjerling-Leffler J
  • Article: NAT MENT HEALTH. 2025;3(9):1002-1011
    Pasman JA; Bergstedt J; Harder A; Gong T; Xiong Y; Hagg S; Fang F; Treur JL; Choi KW; Sullivan PF; Lu Y
  • Journal article: RES SQ. 2024
    Koch E; Jürgenson T; Einarsson G; Mitchell B; Harder A; García-Marín LM; Krebs K; Lin Y; Shadrin A; Xiong Y; Frei O; Lu Y; Hägg S; Renteria M; Medland S; Wray N; Martin N; Hübel C; Breen G; Thorgeirsson T; Stefansson H; Stefansson K; Lehto K; Milani L; Andreassen O; O Connell K
  • Article: JAMA PSYCHIATRY. 2024;81(12):1246-1252
    Song J; Pasman JA; Johansson V; Kuja-Halkola R; Harder A; Karlsson R; Lu Y; Kowalec K; Pedersen NL; Cannon TD; Hultman CM; Sullivan PF
  • Article: INFLAMMATORY BOWEL DISEASES. 2024;30(9):1556-1565
    Gong T; Brew BK; Lundholm C; Smew AI; Harder A; Kuja-Halkola R; Ludvigsson JF; Lu Y; Almqvist C
  • Article: COMMUNICATIONS BIOLOGY. 2024;7(1):1077
    Gong T; Kuja-Halkola R; Harder A; Lundholm C; Smew AI; Lehto K; Andreasson A; Lu Y; Talley NJ; Pasman JA; Almqvist C; Brew BK
  • Article: JAMA PSYCHIATRY. 2024;81(8):807-816
    Grimes PZ; Adams MJ; Thng G; Edmonson-Stait AJ; Lu Y; Mcintosh A; Cullen B; Larsson H; Whalley HC; Kwong ASF
  • Article: MOLECULAR PSYCHIATRY. 2024;29(7):1941-1950
    Song J; Jonsson L; Lu Y; Bergen SE; Karlsson R; Smedler E; Gordon-Smith K; Jones I; Jones L; Craddock N; Sullivan PF; Lichtenstein P; Di Florio A; Landen M
  • Article: NATURE COMMUNICATIONS. 2024;15(1):5064
    Meijsen J; Hu K; Krebs MD; Athanasiadis G; Washbrook S; Zetterberg R; Silva RNAE; Shorter JR; Gadin JR; Bergstedt J; Howard DM; Ye W; Lu Y; Valdimarsdottir UA; Ingason A; Helenius D; Plana-Ripoll O; Mcgrath JJ; Micali N; Andreassen OA; Werge TM; Fang F; Buil A
  • Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(6):754-769
    Bergstedt J; Pasman JA; Ma Z; Harder A; Yao S; Parker N; Treur JL; Smit DJA; Frei O; Shadrin AA; Meijsen JJ; Shen Q; Hägg S; Tornvall P; Buil A; Werge T; Hjerling-Leffler J; Als TD; Børglum AD; Lewis CM; McIntosh AM; Valdimarsdóttir UA; Andreassen OA; Sullivan PF; Lu Y; Fang F
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Forskningsbidrag

  • Att specificera sambandet mellan missbruk och schizofreni, med fokus på ungdomar och unga vuxna
    FORTE
    1 January 2025 - 31 December 2027
  • Swedish Research Council
    1 January 2025 - 31 December 2027
    Schizophrenia and related psychoses are associated with obstetric complications but whether these associations are causal is yet to be explored. This study investigates the relationship between specific complications (e.g. preterm birth, growth restriction, hypoxia), genetic predisposition, and schizophrenia risk using a comprehensive approach integrating large-scale register-based cohort studies, genetically-informed designs, individual genotypes, and detailed familial health data.This is finally possible since we are updating our register linkage, Psychiatry Sweden, to include follow-up data until 2022, thereby enhancing our power (N=25 000 individuals with schizophrenia spectrum disorders). This presents an opportunity to combine a total-population cohort study with genetically-informed designs, such as sibling- and cousin-comparison studies, and pedigree-based family psychiatric history risk scores using familial health records in up to third degree relatives, to enhance the robustness of our causal inference. Finally, we have now genotyped a sub-set of 3000 individuals with schizophrenia and 2500 controls. Integrating  individual genotype data with health registers, we will examine the joint influence of genetics and obstetric complications on schizophrenia risk using polygenic risk scores and tentatively pathway analyses.Together these studies will add to the etiological knowledge about schizophrenia but also whether maternity care could constitute a way of prevention.
  • Swedish Research Council
    1 January 2025 - 31 December 2028
    The MoodMAP project targets the challenge of diagnosing and treating reproductive mood disorders (RMDs), such as premenstrual disorder and postpartum depression, which significantly affect women’s health and contribute to the mental health gender gap. Emerging evidence including our own indicate that these disorders, linked to hormonal changes, may be influenced by genetic predisposition, chronic inflammation, and metabolic dysfunction. Our goals are to uncover new biomarkers, understand the biological underpinnings of women’s susceptibility to mood disorders, and improve strategies for diagnosis, prevention, and treatment. Utilizing data from three Nordic cohorts, the project will:1) integrate genomic, inflammatory proteomic, and metabolomic data to map RMDs’ molecular architecture
    2) identify functional and causal biomarkers through hormone-manipulated cell data and epidemiological methods
    3) predict clinical prognosis using multi-omics data and machine learning.By studying RMDs in concert, MoodMAP aims to reveal the biological basis of female vulnerability to mood disorders, employing advanced omics techniques and state-of-the-art design and analytic methods. The research team is experienced and interdisciplinary in nature, with specific milestones mapped out for each aim over five years. This project is poised to transform our understanding of RMDs, enhancing diagnostic and therapeutic approaches and ultimately addressing the gender gap in mental health.
  • National Institutes of Health
    6 May 2024 - 28 February 2029
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2024 - 31 December 2026
    Research problem and specific questionsSex/gender differences in mental health among adolescents and young adults (AYAs) are well documented. Yet, the driving forces are poorly understood. Premenstrual disorders (PMDs) are common yet under-investigated mental/behavioral conditions emerging during adolescence, with a significant psychosocial impact on young women. Our recent work based on cross-sectional data revealed that the higher prevalence rates of depression and anxiety in adolescent girls than boys did not emerge until menarche and were almost fully attributable to PMDs. However, prospective data are urgently needed to demonstrate the causal relations between PMDs and mental ill-health in young women, and subsequently the contribution to the sex disparities in AYAs mental health.Data and methodsLeveraging the nationwide Swedish register data and two large prospective cohorts (the LifeGene and CATSS), this proposal aims to develop a strategy roadmap for future interventions reducing mental health sex/gender disparities among AYAs through novel prevention programs for PMDs. Specifically, we aim to: 1) assess the association of PMDs and subsequent risks of depression and anxiety using population and sibling analyses
    2) quantify the mediating role of PMDs in the sex differences in mental health and suicidal behavior using mediation analysis
    and 3) determine modifiable childhood causal risk factors for PMDs using Mendelian randomization (MR) analysis.Plan for project realizationThe research team consists of multidisciplinary experts from epidemiology, OB/GYN, psychology/psychiatry, and genetics from Iceland, Sweden, and the US. The applicant has extensive experience in conducting cutting-edge studies on women´s mental health, particularly among AYAs, using registers and large population-based cohorts with advanced methods integrating omics data. One full-time PhD student and 70% of a postdoc will be financed to implement the projects over 3 years under the applicant´s supervision. RelevanceMental ill-health is the leading cause of disease burden among AYAs in Sweden and the sex/gender disparity is alarmingly concerning. However, very limited progress has been implemented so far. Through this program, we will fill an important knowledge gap in the contribution of PMDs to the sex/gender disparities in AYAs mental health, and provide innovative guidelines for future interventions targeted to reduce such disparities.
  • Karolinska institutet
    1 January 2024 - 31 December 2028
  • European Research Council
    1 October 2022 - 30 September 2027
  • Swedish Research Council
    1 January 2022 - 31 December 2025
    Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Although current treatments are generally effective, up to one-third of patients fail to respond to first line therapies, and are referred to as having treatment-resistant depression (TRD). TRD patients have higher rates of mortality, higher health care costs, and are hospitalized longer compared to other depression patients. Therefore, deep knowledge about genetic and non-genetic factors underlying TRD is urgently needed. Leveraging powerful resources of the Swedish national registries and genomic data from clinically-ascertained cohorts, this program aims to systematically study this ‘difficult-to-treat’ form of depression. Specifically, we aim to 1) investigate the genetic epidemiology of TRD, in particular to quantify heritability and genetic correlations
    2) identify and replicate specific genetic markers associated with TRD
    and 3) develop prediction models for TRD by integrating register and genomic data. The applicant will actively lead this program and establish a multidisciplinary team across epidemiology, genetic epidemiology, psychiatry, and machine learning. This program will offer novel insights into the biological underpinnings of TRD, and has great potential to enable early detection of TRD patients at psychiatric clinics, thereby to reduce morbidity, mortality, and suffering in patients with this severe form of the disorder.
  • the European Union’s Horizon 2020 research and innovation programme
    1 June 2021 - 31 December 2025
  • National Institutes of Health
    10 June 2020 - 31 March 2025

Anställningar

  • Senior Forskare, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2022-
  • Forskarassistent, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2018-2021
  • Postdoktor, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2017-2018

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