Ulrika Marklund

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

My major research interest has always been centered around the development and function of neural cell types. During my PhD at the Department of Cell and Molecular Biology at KI, I studied transcriptional determinants of specific neuronal identities including the dopaminergic and serotonergic
neurons of the brain. I thereafter transitioned my research focus to the “Brain in the gut” – the Enteric Nervous System, during a postdoc at National Institute for Medical Research in Mill Hill, London, UK. Since 2013,
I have led my own research group at the Department of Medical Biochemistry and Biophysics.
1996-2001 Master in Molecular Biology, Umeå University
1999-2000 ERASMUS exchange year, University of Manchester, UK
2002-2008 PhD candidate, Dept Cell and Molecular Biology, Karolinska
Institutet
2009-2010 Postdoc, National Institute for Medical Research
Mill Hill,
London, UK

Forskningsbeskrivning

My research team focuses on neural cell diversity in the Enteric Nervous System (ENS). By determining the variety of ENS cell subtypes, the functions they normally serve and their developmental specification we aim to improve diagnostic and therapeutic principles for gut disorders. The lab addresses these basic but critical questions by transcriptome analysis
coupled with viral-based activity/gene manipulations using the mouse model.

Artiklar

Article: NATURE NEUROSCIENCE. 2024;27(12):2267-2268
Ernest Arenas (1962-2024)
Ernfors P; Castelo-Branco G; Uhlen P; Linnarsson S; Marklund U; Hjerling-Leffler J; Dagliyan O
Article: BIOMOLECULES. 2023;13(7):1063
Quantitative Spatial Analysis of Neuroligin-3 mRNA Expression in the Enteric Nervous System Reveals a Potential Role in Neuronal-Glial Synapses and Reduced Expression in Nlgn3^R451C Mice
Herath M; Cho E; Marklund U; Franks AE; Bornstein JC; Hill-Yardin EL
Article: STEM CELL REPORTS. 2021;16(11):2718-2735
Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease
Oosterveen T; Garcao P; Moles-Garcia E; Soleilhavoup C; Travaglio M; Sheraz S; Peltrini R; Patrick K; Labas V; Combes-Soia L; Marklund U; Hohenstein P; Panman L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(6):145837
Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans
Le T-L; Galmiche L; Levy J; Suwannarat P; Hellebrekers DM; Morarach K; Boismoreau F; Theunissen TEJ; Lefebvre M; Pelet A; Martinovic J; Gelot A; Guimiot F; Calleroz A; Gitiaux C; Hully M; Goulet O; Chardot C; Drunat S; Capri Y; Bole-Feysot C; Nitschke P; Whalen S; Mouthon L; Babcock HE; Hofstra R; de Coo IFM; Tabet A-C; Molina TJ; Keren B; Brooks A; Smeets HJM; Marklund U; Gordon CT; Lyonnet S; Amiel J; Bondurand N
Article: NATURE NEUROSCIENCE. 2021;24(1):34-46
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing
Morarach K; Mikhailova A; Knoflach V; Memic F; Kumar R; Li W; Ernfors P; Marklund U
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:6
Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia
Kastriti ME; Kameneva P; Kamenev D; Dyachuk V; Furlan A; Hampl M; Memic F; Marklund U; Lallemend F; Hadjab S; Calvo-Enrique L; Ernfors P; Fried K; Adameyko I
Article: CELL. 2018;174(4):999-1014.e22
Molecular Architecture of the Mouse Nervous System
Zeisel A; Hochgerner H; Lonnerberg P; Johnsson A; Memic F; van der Zwan J; Haring M; Braun E; Borm LE; La Manno G; Codeluppi S; Furlan A; Lee K; Skene N; Harris KD; Hjerling-Leffler J; Arenas E; Ernfors P; Marklund U; Linnarsson S
Article: ELIFE. 2018;7:e34465
Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage
Kaucka M; Petersen J; Tesarova M; Szarowska B; Kastriti ME; Xie M; Kicheva A; Annusver K; Kasper M; Symmons O; Pan L; Spitz F; Kaiser J; Hovorakova M; Zikmund T; Sunadome K; Matise MP; Wang H; Marklund U; Abdo H; Ernfors P; Maire P; Wurmser M; Chagin AS; Fried K; Adameyko I
Article: GASTROENTEROLOGY. 2018;154(3):624-636
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
Memic F; Knoflach V; Morarach K; Sadler R; Laranjeira C; Hjerling-Leffler J; Sundstrom E; Pachnis V; Marklund U
Article: SCIENCE. 2017;357(6346):46
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
Furlan A; Dyachuk V; Kastriti ME; Calvo-Enrique L; Abdo H; Hadjab S; Chontorotzea T; Akkuratova N; Usoskin D; Kamenev D; Petersen J; Sunadome K; Memic F; Marklund U; Fried K; Topilko P; Lallemend F; Kharchenko PV; Ernfors P; Adameyko I
Article: JOURNAL OF NEUROSCIENCE. 2016;36(15):4339-4350
Ascl1 Is Required for the Development of Specific Neuronal Subtypes in the Enteric Nervous System
Memic F; Knoflach V; Sadler R; Tegerstedt G; Sundstrom E; Guillemot F; Pachnis V; Marklund U
Article: SCIENCE. 2014;345(6192):82-87
Parasympathetic neurons originate from nerve-associated peripheral glial progenitors
Dyachuk V; Furlan A; Shahidi MK; Giovenco M; Kaukua N; Konstantinidou C; Pachnis V; Memic F; Marklund U; Mueller T; Birchmeier C; Fried K; Ernfors P; Adameyko I
Article: STEM CELLS AND DEVELOPMENT. 2014;23(1):5-15
Detailed Expression Analysis of Regulatory Genes in the Early Developing Human Neural Tube
Marklund U; Alekseenko Z; Andersson E; Falci S; Westgren M; Perlmann T; Graham A; Sundstrom E; Ericson J
Article: DEVELOPMENT. 2010;137(23):4051-4060
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning
Lek M; Dias JM; Marklund U; Uhde CW; Kurdija S; Lei Q; Sussel L; Rubenstein JL; Matise MP; Arnold H-H; Jessell TM; Ericson J
Article: JOURNAL OF CELL SCIENCE. 2010;123(17):2931-2942
Control of Notch-ligand endocytosis by ligand-receptor interaction
Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U
Article: DEVELOPMENT. 2010;137(3):437-445
Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression
Marklund U; Hansson EM; Sundstrom E; de Angelis MH; Przemeck GKH; Lendahl U; Muhr J; Ericson J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(18):7613-7618
Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
Friling S; Andersson E; Thompson LH; Jonssonc ME; Hebsgaard JB; Nanou E; Alekseenko Z; Marklund U; Kjellander S; Volakakis N; Hovatta O; El Manira A; Bjorklund A; Perlmann T; Ericson J
Article: CELL. 2006;124(2):393-405
Identification of intrinsic determinants of midbrain dopamine neurons
Andersson E; Tryggvason U; Deng QL; Friling S; Alekseenko Z; Robert B; Perlmann T; Ericson J
Article: NATURE NEUROSCIENCE. 2003;6(9):933-938
Lmx1b is essential for the development of serotonergic neurons
Ding YQ; Marklund U; Yuan WL; Yin J; Wegman L; Ericson J; Deneris E; Johnson RL; Chen ZF

Alla övriga publikationer

Editorial comment: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY. 2022;19(2):85-86
Diversity, development and immunoregulation of enteric neurons
Marklund U
Preprint: BIORXIV. 2020
Diversification of molecularly defined myenteric neuron classes revealed by single cell RNA-sequencing
Morarach K; Mikhailova A; Knoflach V; Memic F; Kumar R; Li W; Ernfors P; Marklund U
Thesis / dissertation: 2008
Regional control of cell fate determination and neurogenesis in the developing CNS
Marklund, Ulrika

Forskningsbidrag

The enteric nervous system connectome in health and disease
Swedish Research Council
1 January 2023 - 31 December 2027
Functional dissection of newly discovered cell types in the enteric nervous system
Swedish Research Council
1 January 2021 - 31 December 2024
Dechiffrering av cellöden med in utero-transduktion
Knut and Alice Wallenberg Foundation
1 January 2020
Diversification of the Enteric Nervous System from Immature Stem Cells to Functional Neurons – a Basis for Characterization and Treatment of Bowel Pathology.
Swedish Research Council
1 January 2017 - 31 December 2020
Specification of enteric neuronal subtypes during the development - molecular mechanisms and implications for future regenerative medicine.
Swedish Research Council
1 January 2013 - 31 December 2016

Anställningar

Senior Forskare, Medicinsk biokemi och biofysik, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Neurovetenskap, Karolinska Institutet, 2024
Filosofie Doktorsexamen, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2008

Om mig

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI