Kristina Broliden

Kristina Broliden

Professor/Senior Physician | Docent
Telephone: +46852481571
Visiting address: B2:03, Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Infekt Broliden K, 171 77 Stockholm
Part of:

About me

  • Professor and Senior Consultant, Unit of Infectious Diseases, Karolinska Institutet and Clinic of Infectious Diseases, Karolinska University Hospital

Research

  • The genital microbiome, sex hormones, and hormonal contraceptives are factors that affect susceptibility to sexually transmitted infections. This has been demonstrated in epidemiological and experimental studies across different populations and geographical settings. However, the molecular mechanisms underlying these findings need further clarification. Our research group aims to investigate how these factors impact the human female genital mucosa. We collect and analyze genital mucosal samples from cohorts of Swedish and Kenyan women, focusing on microbiome composition, host transcriptomic and protein profiling, as well as distribution of various immune cell populations. Our methods include digitalized 

  • in situ imaging analysis, 3D-tissue explant models as well as spatial transcriptomics and other multi-omics analyses of mucosal samples. By uncovering some of the underlying mechanisms related to a dysfunctional mucosal barrier, we hope to contribute to the development of topical prophylactic compounds against sexually transmitted infections, including the human immunodeficiency virus (HIV).

Teaching

  • Director of Undergraduate Education at the Department of Medicine Solna

Articles

All other publications

Grants

Employments

  • Professor/Senior Physician, Department of Medicine, Karolinska Institutet, 2005-

Degrees and Education

  • Docent, Karolinska Institutet, 1995
  • University Medical Degree, Karolinska Institutet, 1990
  • PhD, Immunology and virology, Karolinska Institutet (KI), 1989

Leadership and responsibility assignments

  • Head of department, Department of Medicine Solna, Karolinska Institutet, 2015-2020
  • Head of Division, Division of Clinical Virology, Karolinska University Hospital, Huddinge, 2000-2004

News from KI

Events from KI