Kristina Broliden
About me
- Professor and Senior Consultant, Unit of Infectious Diseases, Karolinska Institutet and Clinic of Infectious Diseases, Karolinska University Hospital
Research
The genital microbiome, sex hormones, and hormonal contraceptives are factors that affect susceptibility to sexually transmitted infections. This has been demonstrated in epidemiological and experimental studies across different populations and geographical settings. However, the molecular mechanisms underlying these findings need further clarification. Our research group aims to investigate how these factors impact the human female genital mucosa. We collect and analyze genital mucosal samples from cohorts of Swedish and Kenyan women, focusing on microbiome composition, host transcriptomic and protein profiling, as well as distribution of various immune cell populations. Our methods include digitalized
- in situ imaging analysis, 3D-tissue explant models as well as spatial transcriptomics and other multi-omics analyses of mucosal samples. By uncovering some of the underlying mechanisms related to a dysfunctional mucosal barrier, we hope to contribute to the development of topical prophylactic compounds against sexually transmitted infections, including the human immunodeficiency virus (HIV).
Teaching
Director of Undergraduate Education at the Department of Medicine Solna
Articles
- Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2024;91(2)
- Article: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1454006
- Article: JOURNAL OF INFECTIOUS DISEASES. 2023;227(10):1214-1218
- Article: SCIENTIFIC REPORTS. 2023;13(1):7547
- Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(8):1428-1440
- Article: PLOS PATHOGENS. 2022;18(5):e1010494
- Article: JOURNAL OF INFECTIOUS DISEASES. 2022;225(7):1151-1161
- Journal article: JOURNAL OF CLINICAL VIROLOGY PLUS. 2021;1(3):100033
- Article: VACCINES. 2021;9(3):217
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(15):E5305-5305
- Article: MICROBIOME. 2020;8(1):61
- Article: JOURNAL OF PEDIATRICS. 2020;216:150-157.e1
- Article: SCIENTIFIC REPORTS. 2019;9(1):18120
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2019;35(3):236-246
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(3):461-476
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(49):E11513-E11522
- Article: AMERICAN JOURNAL OF INFECTION CONTROL. 2018;46(12):1394-1399
- Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(140)
- Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(140)
- Article: SCIENTIFIC REPORTS. 2018;8(1):10180
- Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):453-465
- Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2018;80(1):e12863
- Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2018;37(3):246-252
- Article: PLOS PATHOGENS. 2017;13(5):e1006402
- Article: JOURNAL OF INFECTIOUS DISEASES. 2017;215(4):590-598
- Article: MUCOSAL IMMUNOLOGY. 2017;10(1):35-45
- Article: JOURNAL OF VIROLOGY. 2016;90(21):9855-9861
- Article: NATURE BIOTECHNOLOGY. 2016;34(10):1066-1071
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(5):1843-1851
- Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2016;76(1):82-93
- Article: RESPIRATORY MEDICINE. 2016;115:1-6
- Article: INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH & WELL-BEING. 2016;11:32378
- Article: PLOS ONE. 2016;11(6):e0157398
- Article: AMERICAN JOURNAL OF INFECTION CONTROL. 2015;43(12):1302-1309
- Article: THORAX. 2015;70(9):847-853
- Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2015;43(3):302-308
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2015;69(1):1-10
- Article: BIOLOGY OF REPRODUCTION. 2015;92(3):68-10
- Article: PLOS ONE. 2015;10(6):e0130404
- Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2015;46(1):107-112
- Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;72(5):475-484
- Article: PLOS PATHOGENS. 2014;10(10):e1004416
- Article: JOURNAL OF IMMUNOLOGY. 2014;192(8):3947-3957
- Article: PEDIATRICS. 2014;133(3):e538-e545
- Article: PLOS ONE. 2014;9(6):e100820
- Article: JOURNAL OF IMMUNOLOGY. 2013;191(7):3948-3954
- Article: JOURNAL OF INTERNAL MEDICINE. 2013;274(4):363-370
- Article: JOURNAL OF VIROLOGY. 2013;87(9):5141-5150
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2013;45(4):285-291
- Article: AIDS. 2012;26(17):2155-2163
- Article: JOURNAL OF VIROLOGY. 2012;86(21):11899-11905
- Article: AIDS. 2012;26(15):1857-1867
- Article: PLOS ONE. 2012;7(2):e30819
- Article: PLOS ONE. 2012;7(7):e41271
- Article: PLOS ONE. 2012;7(5):e36543
- Article: PLOS ONE. 2012;7(2):e31996
- Article: BONE MARROW TRANSPLANTATION. 2011;46(2):267-272
- Article: PLOS ONE. 2011;6(6):e21344
- Article: PLOS ONE. 2011;6(9):e25551
- Article: BMC INFECTIOUS DISEASES. 2010;10:340
- Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2010;37(6):1565-1573
- Article: HUMAN IMMUNOLOGY. 2010;71(7):733-735
- Article: AIDS. 2010;24(10):1569-1575
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(6):2798-2805
- Article: AIDS. 2010;24(7):969-974
- Article: JOURNAL OF CLINICAL VIROLOGY. 2010;47(3):234-237
- Article: AIDS. 2010;24(1):35-43
- Article: AIDS. 2009;23(13):1669-1677
- Article: SEMINARS IN FETAL AND NEONATAL MEDICINE. 2009;14(4):218-221
- Article: AIDS. 2009;23(3):329-333
- Article: JOURNAL OF INTERNAL MEDICINE. 2009;265(1):5-17
- Journal article: BLOOD. 2008;112(11):4745
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2008;14(10):1172-1179
- Article: JOURNAL OF CLINICAL VIROLOGY. 2008;43(1):79-85
- Journal article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;93(1):56-64
- Article: CLINICAL INFECTIOUS DISEASES. 2008;46(4):528-536
- Article: CURRENT HIV RESEARCH. 2008;6(1):28-33
- Article: CURRENT HIV RESEARCH. 2007;5(4):410-415
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2007;147(3):419-425
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2007;23(1):101-106
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2006;43(2):137-143
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2006;22(9):908-911
- Article: JOURNAL OF VIROLOGY. 2006;80(13):6697-6701
- Article: JOURNAL OF MEDICAL VIROLOGY. 2006;78(1):129-133
- Article: PLOS MEDICINE. 2005;2(12):e343-1291
- Article: JOURNAL OF VIROLOGY. 2005;79(18):12117-12121
- Article: JOURNAL OF CLINICAL VIROLOGY. 2005;33(1):71-74
- Journal article: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2005;60(5):284-286
- Article: JOURNAL OF PERINATAL MEDICINE. 2005;33(2):176-178
- Article: JOURNAL OF IMMUNOLOGY. 2004;173(11):7078-7089
- Article: EXPERIMENTAL HEMATOLOGY. 2004;32(11):1082-1087
- Article: PEDIATRIC BLOOD AND CANCER. 2004;42(4):357-360
- Article: JOURNAL OF PERINATAL MEDICINE. 2004;32(6):516-521
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2004;36(9):663-669
- Article: CLINICAL INFECTIOUS DISEASES. 2002;35(9):1032-1038
- Article: CLINICAL INFECTIOUS DISEASES. 2002;35(9):1027-1031
- Journal article: OBSTETRICS AND GYNECOLOGY. 2002;100(4):831-832
- Article: AIDS. 2002;16(13):1731-1741
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2002;30(4):413-420
- Article: PATHOLOGIE ET BIOLOGIE. 2002;50(5):317-325
- Article: OBSTETRICS AND GYNECOLOGY. 2002;99(5):795-798
- Article: PEDIATRIC TRANSPLANTATION. 2001;5(5):320-330
- Article: THE LANCET. 2001;357(9267):1494-1497
- Article: JOURNAL OF VIROLOGY. 2001;75(1):540-543
- Article: FETAL DIAGNOSIS AND THERAPY. 2001;16(1):26-31
- Article: VACCINE. 2000;19(7-8):758-763
- Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):5170-5176
- Article: AIDS. 2000;14(13):1917-1920
- Article: VIROLOGY. 2000;270(1):135-145
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2000;238(1-2):69-80
- Article: BJOG: AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 2000;107(4):476-480
- Article: TIDSSKRIFT FOR DEN NORSKE LEGEFORENING. 2000;120(4):455-458
- Article: JOURNAL OF MEDICAL VIROLOGY. 2000;60(1):48-55
- Article: AIDS. 2000;14:S167-S174
- Article: LAKARTIDNINGEN. 1999;96(46):5066-5069
- Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 1999;78(9):828-830
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1999;31(1):11-16
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1999;31(2):119-122
- Article: PEDIATRIC BLOOD AND CANCER. 1998;31(2):66-72
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1998;30(1):23-27
- Article: VACCINE. 1998;16(2-3):323-327
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1996;12(18):1699-1702
- Article: AIDS. 1996;10(11):1199-1204
- Article: CLINICAL AND DIAGNOSTIC VIROLOGY. 1996;6(2-3):115-126
- Article: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 1996;12(3):221-232
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1996;12(8):705-713
- Article: CLINICAL AND VACCINE IMMUNOLOGY. 1996;3(2):147-150
- Journal article: AIDS. 1994;8(Supplement 4):s13
- Journal article: VACCINE. 1994;12(13):1203-1208
- Journal article: JOURNAL OF MEDICAL PRIMATOLOGY. 1994;23(2-3):89-94
- Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1993;9(9):883-889
- Journal article: IMMUNOLOGY. 1992;76(4):515-534
- Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1992;8(6):1133-1138
- Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1992;8(4):435-442
- Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1992;89(2):461-465
- Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1991;7(12):983-990
- Journal article: VIROLOGY. 1991;185(1):162-168
- Journal article: IMMUNOLOGY. 1991;73(4):371-376
- Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(14):6082-6086
- Journal article: JOURNAL OF INFECTIOUS DISEASES. 1990;161(2):198-202
- Journal article: JOURNAL OF VIROLOGY. 1990;64(2):936-940
- Journal article: ZEITSCHRIFT F�R KLINISCHE MEDIZIN. 1990;45(4):371-374
- Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1989;5(6):629-638
- Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1989;86(20):8055-8058
- Journal article: AIDS. 1989;3(9):577-582
- Journal article: JOURNAL OF VIROLOGY. 1989;63(8):3376-3381
- Journal article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 1989;75(2):184-189
- Journal article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 1988;73(3):339-342
- Journal article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 1988;73(3):343-347
- Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1988;4(3):199-210
- Journal article: JOURNAL OF IMMUNOLOGY. 1988;140(2):602-605
- Journal article: ARCHIVES OF VIROLOGY. 1988;103(3-4):189-206
- Journal article: JOURNAL OF IMMUNOLOGICAL METHODS. 1987;104(1-2):7-14
- Journal article: JOURNAL OF IMMUNOLOGY. 1987;139(7):2263-2267
- Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1986;23(6):639-645
- Journal article: CELLULAR IMMUNOLOGY. 1986;100(1):158-166
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All other publications
- Review: FRONTIERS IN IMMUNOLOGY. 2022;13:1055042
- Conference publication: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(2):AB99
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2018;34:310
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2018;34:282
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2018;34:204
- Book chapter: ENCYCLOPEDIA OF AIDS. 2018;p. 842-849
- Corrigendum: PLOS PATHOGENS. 2017;13(7):e1006492
- Corrigendum: JOURNAL OF VIROLOGY. 2017;91(3):e02074-e02016
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):281
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):288-289
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:773-774
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:307
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:306
- Corrigendum: PLOS ONE. 2015;10(7):e0134196
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A47-A48
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A82-A83
- Book chapter: ENCYCLOPEDIA OF AIDS. 2014;p. 1-8
- Letter: BONE MARROW TRANSPLANTATION. 2013;48(10):1366-1367
- Conference publication: RETROVIROLOGY. 2012;9:p190
- Book chapter: MODELS OF PROTECTION AGAINST HIV/SIV. 2012;p. 145-168
- Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2010;202:S351-S355
- Letter: CLINICAL INFECTIOUS DISEASES. 2010;50(10):1426-1427
- Meeting abstract: RETROVIROLOGY. 2009;6:p231
- Meeting abstract: RETROVIROLOGY. 2009;6:p44
- Published conference paper: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2009;51(3):239-247
- Letter: AIDS. 2008;22(17):2401-2402
- Conference publication: BONE MARROW TRANSPLANTATION. 2008;41:S322
- Published conference paper: JOURNAL OF INTERNAL MEDICINE. 2007;262(1):44-58
- Editorial comment: SEMINARS IN FETAL AND NEONATAL MEDICINE. 2007;12(3):153
- Review: JOURNAL OF INTERNAL MEDICINE. 2006;260(4):285-304
- Meeting abstract: BLOOD. 2005;106(11):214B
- Editorial comment: CLINICAL INFECTIOUS DISEASES. 2005;41(8):1201-1203
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2005;52(9):S681
- Review: LAKARTIDNINGEN. 2003;100(4):222-224
- Letter: OBSTETRICS AND GYNECOLOGY. 2002;100(4):831-832
- Published conference paper: IMMUNOLOGY LETTERS. 2001;79(1-2):29-36
- Letter: THE LANCET. 2001;358(9288):1180
- Letter: AIDS. 2001;15(3):431-432
- Letter: BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 2000;107(10):1324
- Letter: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 1999;180(6):1595-1596
- Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1993;:72
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1990;6(1):29
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Grants
- The impact of Depot Medroxyacetate (DMPA) on inflammation in female sex workers-implication for HIV susceptibilityCanadian Institutes of Health Research1 July 2024 - 30 June 2029
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council1 January 2022 - 31 December 2024
- Swedish Research Council1 December 2021 - 30 November 2024
- Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications, antimicrobial drug resistance, and unresponsiveness to therapeutic HIV-1 vaccinationEuropean Union Horizon20201 July 2020 - 31 December 2025
- Swedish Research Council1 January 2020 - 31 December 2021
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Research Council1 November 2018 - 30 November 2018
- Swedish Research Council1 January 2017 - 31 December 2019
- Swedish Research Council1 January 2017 - 31 December 2019
- Understanding mucosal protection against HIV: delineating interactions between the immune system, microbiome and mucus.Canadian Institutes of Health Research1 January 2015 - 31 December 2017
- Mucosal predictors of HIV acquisitionCanadian Institutes of Health Research1 January 2015 - 31 December 2017
- Applying novel ex vivo and in vitro assays to define mechanisms of HIV protection in the foreskin.Canadian Institutes of Health Research1 October 2014 - 30 September 2015
- Swedish Research Council1 January 2014 - 31 December 2016
- Defining the immune mechanisms of HIV acquisition in the foreskin.Canadian Institutes of Health Research1 March 2013 - 28 February 2014
- Swedish Research Council1 January 2011 - 31 December 2013
Employments
- Professor/Senior Physician, Department of Medicine, Karolinska Institutet, 2005-
Degrees and Education
- Docent, Karolinska Institutet, 1995
- University Medical Degree, Karolinska Institutet, 1990
- PhD, Immunology and virology, Karolinska Institutet (KI), 1989
Leadership and responsibility assignments
- Head of department, Department of Medicine Solna, Karolinska Institutet, 2015-2020
- Head of Division, Division of Clinical Virology, Karolinska University Hospital, Huddinge, 2000-2004