Rickard Sandberg

Rickard Sandberg

Professor
Telefon: +46852482941
Besöksadress: Solnavägen 9, 17165 Stockholm
Postadress: C5 Cell- och molekylärbiologi, C5 CMB Sandberg, 171 77 Stockholm
Del av:

Om mig

  • Utbildning
    - Doktorandstudier, institutionen för mikrobiologi, tumör- och cellbiologi (MTC), Karolinska Institutet, Stockholm, Sweden 2000-2004.
    - Postdoktorala studier, Massachusetts Institute of Technology (MIT), Cambridge, US 2005-2007.
    - Forskarassistent, institutionen för cell- och molekylärbiologi (CMB), Karolinska Institutet, Sweden 2008-2013.
    - Docent, institutionen för cell- och molekylärbiologi (CMB), Karolinska Institutet, Sweden 2013-

    Akademiska priser och utmärkelser
    - Torsten Söderbergs akademiprofessur i medicin 2022
    - Elected Member of EMBO 2019.
    - Elected Member of the Nobel Assembly at Karolinska Institutet 2019.
    - Anders Jahre's medical prize for young medical researchers (Nordic prize) 2014
    - EMBO Young Investigator 2012
    - Sven and Ebba-Christina Hagbergs Prize 2012

Utvalda publikationer

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Cancer Society
    1 januari 2022
    Cancer research has resulted in thousands of active substances that have been tested or used in the clinical treatment of cancer. These affect various cellular processes in the cell such as cell division, repair of the genetic material, regulation of the genetic material, activation of cell responses or immune cells. Methodology to identify the initial response in the cancer cell after treatment with these substances has unfortunately been lacking, and most of the effects of treatments have been studied at a later stage in the cancer cells. We have developed a methodology that enables the identification of the initial cell responses to treatment in cancer cells. We will study how blood cancer (forms of leukemia) and breast cancer cells respond to treatment with hundreds to thousands of different active substances. This will provide important insights into the exact mechanisms of action of these substances, which we hope can explain why different substances have a better effect on different types of leukemia and breast cancer types. We will also investigate how cancer cells, but also the nearby immune cells and cancer-associated fibroblasts, are affected by the same panel of substances. We hope that the insights into the initial response of cancer cells to treatments can form the basis for more rational development of specific and potent substances, and that it can demonstrate effective combinations of existing substances. In the longer term, we want to investigate whether this method can also show which treatment options are best suited for each individual cancer patient. For example, panels of relevant treatments can be tested on a primary tumor and initial responses read immediately and examined to see if these responses can predict how the tumor will respond to the various treatments in an improved form of precision medicine.
  • Swedish Research Council
    1 januari 2018 - 31 december 2027
    Recent technological advances have enabled global gene expression analyses in single cells, allowing transcriptional programs to be investigated in terms of cellular frequencies and magnitudes. Moving away from population-level experiments depicting cellular averages, to analyses of large numbers of individual cells, promises to dramatically improve our understanding of gene regulation. Indeed, initial analyses revealed stochastic allelic transcription that had been masked in previous population-level experiments. The overarching goal of this proposal is to develop single-cell sequencing technologies that will allow for unprecedented detailed studies of gene regulation. In particular, we will develop massively parallel single-cell transcriptome methods that maintain full-length transcriptome coverage, and genetically engineered mouse models for allele-resolution gene expression and lineage-reconstructions in single cells. These methods will be used to (i) infer transcriptional burst frequencies and magnitudes, and relate those to genomic sequences, (ii) investigate the temporal dynamics of random monoallelic expression at different resolutions in the reconstructed lineage tree, (iii) explore the phenotypic consequences of stochastic allelic expression in the context of variable penetrance and expressivity, common in human genetic disease. Taken together, in this research program we will develop an experimental foundation for gene regulatory studies at single-cell resolution.
  • National Institute of Mental Health
    1 september 2017 - 30 juni 2024
  • Exploring the temporal dynamics of autosomal random monoallelic expression
    International Human Frontier Science Program Organization
    1 maj 2017 - 30 april 2020
  • Knut and Alice Wallenberg Foundation
    1 januari 2017 - 1 januari 2022
  • JPND utlysning 2013. Cross-Disease analysis of pathways.
    Swedish Research Council
    1 december 2014 - 31 december 2016
  • Knut and Alice Wallenberg Foundation
    1 januari 2013 - 1 januari 2018
  • EMBO Young Investigators Award 2012
    Swedish Research Council
    1 januari 2013 - 31 december 2015
  • Swedish Research Council
    1 januari 2013 - 31 december 2017
  • The anatomy of a gene expression program
    Swedish Foundation for Strategic Research
    1 januari 2011 - 31 december 2016
  • Swedish Research Council
    1 januari 2009 - 31 december 2012
  • Swedish Research Council
    1 januari 2009 - 31 december 2012

Anställningar

  • Professor, Molekylär genetik, Cell- och molekylärbiologi, Karolinska Institutet, 2015-

Examina och utbildning

  • Docent, Bioinformatik, Karolinska Institutet, 2013
  • MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2004
  • LICENTIATEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2002
  • Medicine Magisterexamen, Karolinska Institutet, 2000

Handledning

  • Handledning till doktorsexamen

    • Mtakai Ngara, Single-Cell RNA Sequencing for Subtype Discovery in Plasmodium falciparum and Mammalian Cells, 2019

Nyheter från KI

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