Rickard Sandberg

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Utbildning
- Doktorandstudier, institutionen för mikrobiologi, tumör- och cellbiologi (MTC), Karolinska Institutet, Stockholm, Sweden 2000-2004.
- Postdoktorala studier, Massachusetts Institute of Technology (MIT), Cambridge, US 2005-2007.
- Forskarassistent, institutionen för cell- och molekylärbiologi (CMB), Karolinska Institutet, Sweden 2008-2013.
- Docent, institutionen för cell- och molekylärbiologi (CMB), Karolinska Institutet, Sweden 2013-

Akademiska priser och utmärkelser
- Torsten Söderbergs akademiprofessur i medicin 2022
- Elected Member of EMBO 2019.
- Elected Member of the Nobel Assembly at Karolinska Institutet 2019.
- Anders Jahre's medical prize for young medical researchers (Nordic prize) 2014
- EMBO Young Investigator 2012
- Sven and Ebba-Christina Hagbergs Prize 2012

Utvalda publikationer

Article: NATURE BIOTECHNOLOGY. 2020;38(6):708-714
Single-cell RNA counting at allele and isoform resolution using Smart-seq3
Hagemann-Jensen M; Ziegenhain C; Chen P; Ramskold D; Hendriks G-J; Larsson AJM; Faridani OR; Sandberg R
Article: NATURE COMMUNICATIONS. 2019;10(1):3138
NASC-seq monitors RNA synthesis in single cells
Hendriks G-J; Jung LA; Larsson AJM; Lidschreiber M; Forsman OA; Lidschreiber K; Cramer P; Sandberg R
Article: NATURE. 2019;565(7738):251-254
Genomic encoding of transcriptional burst kinetics
Larsson AJM; Johnsson P; Hagemann-Jensen M; Hartmanis L; Faridani OR; Reinius B; Segerstolpe A; Rivera CM; Ren B; Sandberg R
Article: SCIENCE. 2014;343(6167):193-196
Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells
Deng Q; Ramskold D; Reinius B; Sandberg R
Article: NATURE METHODS. 2013;10(11):1096-1098
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Picelli S; Bjorklund AK; Faridani OR; Sagasser S; Winberg G; Sandberg R

Artiklar

Article: NATURE CELL BIOLOGY. 2024;26(10):1725-1733
Single-cell new RNA sequencing reveals principles of transcription at the resolution of individual bursts
Ramskold D; Hendriks G-J; Larsson AJM; Mayr JV; Ziegenhain C; Hagemann-Jensen M; Hartmanis L; Sandberg R
Article: NATURE COMMUNICATIONS. 2024;15(1):8373
Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq.
Noble JC; Lentini A; Hagemann-Jensen M; Sandberg R; Reinius B
Article: GENOME BIOLOGY. 2024;25(1):214
Inferring clonal somatic mutations directed by X chromosome inactivation status in single cells
Demirci I; Larsson AJM; Chen X; Hartman J; Sandberg R; Frisen J
Article: NATURE IMMUNOLOGY. 2024;25(6):1007-1019
Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells
Carrelha J; Mazzi S; Winroth A; Hagemann-Jensen M; Ziegenhain C; Hogstrand K; Seki M; Brennan MS; Lehander M; Wu B; Meng Y; Markljung E; Norfo R; Ishida H; Stralin KB; Grasso F; Karali CS; Aliouat A; Hillen A; Chari E; Siletti K; Thongjuea S; Mead AJ; Linnarsson S; Nerlov C; Sandberg R; Yoshizato T; Woll PS; Jacobsen SEW
Article: ISCIENCE. 2024;27(4):109346
Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia
Di Martino E; Ambikan A; Ramskold D; Umekawa T; Giatrellis S; Vacondio D; Romero AL; Galan MG; Sandberg R; Aden U; Lauschke VM; Neogi U; Blomgren K; Kele J
Article: CELL SYSTEMS. 2024;15(2):149-165.e10
Clonally heritable gene expression imparts a layer of diversity within cell types
Mold JE; Weissman MH; Ratz M; Hagemann-Jensen M; Hard J; Eriksson C-J; Toosi H; Berghenstrahle J; Ziegenhain C; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaeeurolsson J; Frisen J
Article: CANCER RESEARCH. 2024;84(2):211-225
Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts
Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Bjoerklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellstrom-Lindberg E
Article: GENOME BIOLOGY. 2024;25(1):2
Tissue-specific RNA Polymerase II promoter-proximal pause release and burst kinetics in a Drosophila embryonic patterning network
Hunt G; Vaid R; Pirogov S; Pfab A; Ziegenhain C; Sandberg R; Reimegard J; Mannervik M
Article: NATURE AGING. 2023;3(11):1430-1445
Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver
Nikopoulou C; Kleinenkuhnen N; Parekh S; Sandoval T; Ziegenhain C; Schneider F; Giavalisco P; Donahue K-F; Vesting AJ; Kirchner M; Bozukova M; Vossen C; Altmueller J; Wunderlich T; Sandberg R; Kondylis V; Tresch A; Tessarz P
Article: AGING. 2023;15(12):5240-5265
Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis
Salignon J; Faridani OR; Miliotis T; Janssens GE; Chen P; Zarrouki B; Sandberg R; Davidsson P; Riedel CG
Article: DEVELOPMENTAL CELL. 2023;58(6):450-460.e6
A small noncoding RNA links ribosome recovery and translation control to dedifferentiation during salamander limb regeneration
Subramanian E; Elewa A; Brito G; Kumar A; Segerstolpe A; Karampelias C; Bjorklund A; Sandberg R; Echeverri K; Lui W-O; Andersson O; Simon A
Article: NATURE COMMUNICATIONS. 2023;14(1):982
Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics
Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Article: NATURE BIOTECHNOLOGY. 2022;40(10):1452-1457
Scalable single-cell RNA sequencing from full transcripts with Smart-seq3xpress
Hagemann-Jensen M; Ziegenhain C; Sandberg R
Article: NATURE METHODS. 2022;19(5):560-566
Molecular spikes: a gold standard for single-cell RNA counting
Ziegenhain C; Hendriks G-J; Hagemann-Jensen M; Sandberg R
Article: NATURE GENETICS. 2022;54(3):306-317
Transcriptional kinetics and molecular functions of long noncoding RNAs
Johnsson P; Ziegenhain C; Hartmanis L; Hendriks G-J; Hagemann-Jensen M; Reinius B; Sandberg R
Article: NATURE COMMUNICATIONS. 2021;12(1):6216
BAMboozle removes genetic variation from human sequence data for open data sharing
Ziegenhain C; Sandberg R
Article: NATURE. 2021;598(7879):86-102
A multimodal cell census and atlas of the mammalian primary motor cortex
Callaway EM; Dong H-W; Ecker JR; Hawrylycz MJ; Huang ZJ; Lein ES; Ngai J; Osten P; Ren B; Tolias AS; White O; Zeng H; Zhuang X; Ascoli GA; Behrens MM; Chun J; Feng G; Gee JC; Ghosh SS; Halchenko YO; Hertzano R; Lim BK; Martone ME; Ng L; Pachter L; Ropelewski AJ; Tickle TL; Yang XW; Zhang K; Bakken TE; Berens P; Daigle TL; Harris JA; Jorstad NL; Kalmbach BE; Kobak D; Li YE; Liu H; Matho KS; Mukamel EA; Naeemi M; Scala F; Tan P; Ting JT; Xie F; Zhang M; Zhang Z; Zhou J; Zingg B; Bertagnolli D; Casper T; Crichton K; Dee N; Diep D; Ding S-L; Dong W; Dougherty EL; Fong O; Goldman M; Goldy J; Hodge RD; Hu L; Keene CD; Krienen FM; Kroll M; Lake BB; Lathia K; Linnarsson S; Liu CS; Macosko EZ; McCarroll SA; McMillen D; Nadaf NM; Thuc NN; Palmer CR; Thanh P; Plongthongkum N; Reed NM; Regev A; Rimorin C; Romanow WJ; Savoia S; Siletti K; Smith K; Sulc J; Tasic B; Tieu M; Torkelson A; Tung H; van Velthoven CTJ; Vanderburg CR; Yanny AM; Fang R; Hou X; Lucero JD; Osteen JK; Pinto-Duarte A; Poirion O; Preissl S; Wang X; Aldridge AI; Bartlett A; Boggeman L; O'Connor C; Castanon RG; Chen H; Fitzpatrick C; Luo C; Nery JR; Nunn M; Rivkin AC; Tian W; Dominguez B; Ito-Cole T; Jacobs M; Jin X; Lee C-T; Lee K-F; Miyazaki PA; Pang Y; Rashid M; Smith JB; Vu M; Williams E; Armand E; Biancalani T; Booeshaghi AS; Crow M; Dudoit S; Fischer S; Gillis J; Hu Q; Kharchenko PV; Niu S-Y; Ntranos V; Purdom E; Risso D; de Bezieux HR; Somasundaram S; Street K; Svensson V; Vaishnav ED; Van den Berge K; Welch JD; Yao Z; An X; Bateup HS; Bowman I; Chance RK; Foster NN; Galbavy W; Gong H; Gou L; Hatfield JT; Hintiryan H; Hirokawa KE; Kim G; Kramer DJ; Li A; Li X; Luo Q; Munoz-Castaneda R; Stafford DA; Feng Z; Jia X; Jiang S; Jiang T; Kuang X; Larsen R; Lesnar P; Li Y; Li Y; Liu L; Peng H; Qu L; Ren M; Ruan Z; Shen E; Song Y; Wakeman W; Wang P; Wang Y; Wang Y; Yin L; Yuan J; Zhao S; Zhao X; Narasimhan A; Palaniswamy R; Banerjee S; Ding L; Huilgol D; Huo B; Kuo H-C; Laturnus S; Li X; Mitra PP; Mizrachi J; Wang Q; Xie P; Xiong F; Yu Y; Eichhorn SW; Berg J; Bernabucci M; Bernaerts Y; Cadwell CR; Castro JR; Dalley R; Hartmanis L; Horwitz GD; Jiang X; Ko AL; Miranda E; Mulherkar S; Nicovich PR; Owen SF; Sandberg R; Sorensen SA; Tan ZH; Allen S; Hockemeyer D; Lee AY; Veldman MB; Adkins RS; Ament SA; Bravo HC; Carter R; Chatterjee A; Colantuoni C; Crabtree J; Creasy H; Felix V; Giglio M; Herb BR; Kancherla J; Mahurkar A; McCracken C; Nickel L; Olley D; Orvis J; Schor M; Hood G; Dichter B; Grauer M; Helba B; Bandrowski A; Barkas N; Carlin B; D'Orazi FD; Degatano K; Gillespie TH; Khajouei F; Konwar K; Thompson C; Kelly K; Mok S; Sunkin S
Article: NATURE. 2021;598(7879):144-150
Phenotypic variation of transcriptomic cell types in mouse motor cortex
Scala F; Kobak D; Bernabucci M; Bernaerts Y; Cadwell CR; Castro JR; Hartmanis L; Jiang X; Laturnus S; Miranda E; Mulherkar S; Tan ZH; Yao Z; Zeng H; Sandberg R; Berens P; Tolias AS
Article: CELL REPORTS. 2021;35(8):109174
Divergent clonal differentiation trajectories establish CD8⁺ memory T cell heterogeneity during acute viral infections in humans
Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J
Article: NATURE COMMUNICATIONS. 2021;12(1):2141
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
He B; Chen P; Zambrano S; Dabaghie D; Hu Y; Moller-Hackbarth K; Unnersjoe-Jess D; Korkut GG; Charrin E; Jeansson M; Bintanel-Morcillo M; Witasp A; Wennberg L; Wernerson A; Schermer B; Benzing T; Ernfors P; Betsholtz C; Lal M; Sandberg R; Patrakka J
Article: PLOS COMPUTATIONAL BIOLOGY. 2021;17(3):e1008772
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
Larsson AJM; Ziegenhain C; Hagemann-Jensen M; Reinius B; Jacob T; Dalessandri T; Hendriks G-J; Kasper M; Sandberg R
Article: PLOS ONE. 2021;16(4):e0250282
Understanding interactions between risk factors, and assessing the utility of the additive and multiplicative models through simulations
Diaz-Gallo L-M; Brynedal B; Westerlind H; Sandberg R; Ramskold D
Article: NATURE NANOTECHNOLOGY. 2021;16(1):85-95
A DNA-nanoassembly-based approach to map membrane protein nanoenvironments.
Ambrosetti E; Bernardinelli G; Hoffecker I; Hartmanis L; Kiriako G; de Marco A; Sandberg R; Högberg B; Teixeira AI
Article: GENOME RESEARCH. 2020;30(8):1083-1096
LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy
Nichterwitz S; Nijssen J; Storvall H; Schweingruber C; Comley LH; Allodi I; van der Lee M; Deng Q; Sandberg R; Hedlund E
Article: NATURE BIOTECHNOLOGY. 2020;38(6):747-755
Benchmarking single-cell RNA-sequencing protocols for cell atlas projects
Mereu E; Lafzi A; Moutinho C; Ziegenhain C; McCarthy DJ; Alvarez-Varela A; Batlle E; Sagar; Gruen D; Lau JK; Boutet SC; Sanada C; Ooi A; Jones RC; Kaihara K; Brampton C; Talaga Y; Sasagawa Y; Tanaka K; Hayashi T; Braeuning C; Fischer C; Sauers S; Trefzer T; Conrad C; Adiconis X; Nguyen LT; Regev A; Levin JZ; Parekh S; Janjic A; Wange LE; Bagnoli JW; Enard W; Gut M; Sandberg R; Nikaido I; Gut I; Stegle O; Heyn H
Article: ELIFE. 2020;9:e52951
Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex
Cadwell CR; Scala F; Fahey PG; Kobak D; Mulherkar S; Sinz FH; Papadopoulos S; Tan ZH; Johnsson P; Hartmanis L; Li S; Cotton RJ; Tolias KF; Sandberg R; Berens P; Jiang X; Tolias AS
Article: CELL STEM CELL. 2020;26(3):441-457.e7
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost S; Annusver K; Jacob T; Sun X; Dalessandri T; Sivan U; Sequeira I; Sandberg R; Kasper M
Article: BASIC RESEARCH IN CARDIOLOGY. 2019;115(1):7
Cell shape determines gene expression: cardiomyocyte morphotypic transcriptomes
Esfahani PH; ElBeck Z; Sagasser S; Li X; Hossain MB; Talukdar HA; Sandberg R; Knoll R
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2019;26(10):963-969
X-chromosome upregulation is driven by increased burst frequency
Larsson AJM; Coucoravas C; Sandberg R; Reinius B
Article: NATURE COMMUNICATIONS. 2019;10(1):4174
Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas
Scala F; Kobak D; Shan S; Bernaerts Y; Laturnus S; Cadwell CR; Hartmanis L; Froudarakis E; Castro JR; Tan ZH; Papadopoulos S; Patel SS; Sandberg R; Berens P; Jiang X; Tolias AS
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2019;39(7):1402-1418
Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization
Ali Z; Mukwaya A; Biesemeier A; Ntzouni M; Ramskold D; Giatrellis S; Mammadzada P; Cao R; Lennikov A; Marass M; Gerri C; Hildesjo C; Taylor M; Deng Q; Peebo B; del Peso L; Kvanta A; Sandberg R; Schraermeyer U; Andre H; Steffensen JF; Lagali N; Cao Y; Kele J; Dahl Jensen L
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2019;39(7):1432-1447
Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling
Jensen LD; Hot B; Ramskold D; Germano RFV; Yokota C; Giatrellis S; Lauschke VM; Hubmacher D; Li MX; Hupe M; Arnold TD; Sandberg R; Frisen J; Trusohamn M; Martowicz A; Wisniewska-Kruk J; Nyqvist D; Adams RH; Apte SS; Vanhollebeke B; Stenman JM; Kele J
Article: EXPERIMENTAL CELL RESEARCH. 2018;371(1):130-138
Exploring parasite heterogeneity using single-cell RNA-seq reveals a gene signature among sexual stage Plasmodium falciparum parasites
Ngara M; Palmkvist M; Sagasser S; Hjelmqvist D; Bjorklund AK; Wahlgren M; Ankarklev J; Sandberg R
Article: NATURE PROTOCOLS. 2018;13(10):2407-2424
Small-seq for single-cell small-RNA sequencing
Hagemann-Jensen M; Abdullayev I; Sandberg R; Faridani OR
Article: NATURE COMMUNICATIONS. 2018;9(1):1873
Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
Vertesy A; Arindrarto W; Roost MS; Reinius B; Torrens-Juaneda V; Bialecka M; Moustakas I; Ariyurek Y; Kuijk E; Mei H; Sandberg R; van Oudenaarden A; Lopes SMCDS
Article: NATURE METHODS. 2018;15(5):339-342
Identification of spatial expression trends in single-cell gene expression data
Edsgard D; Johnsson P; Sandberg R
Article: GASTROENTEROLOGY. 2018;154(4):1080-1095
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
Andersson ER; Chivukula IV; Hankeova S; Sjoqvist M; Tsoi YL; Ramskold D; Masek J; Elmansuri A; Hoogendoorn A; Vazquez E; Storvall H; Netusilova J; Huch M; Fischler B; Ellis E; Contreras A; Nemeth A; Chien KC; Clevers H; Sandberg R; Bryja V; Lendahl U
Article: NATURE COMMUNICATIONS. 2017;8(1):2286
Reading and editing the Pleurodeles waltl genome reveals novel features of tetrapod regeneration
Elewa A; Wang H; Talavera-Lopez C; Joven A; Brito G; Kumar A; Hameed LS; Penrad-Mobayed M; Yao Z; Zamani N; Abbas Y; Abdullayev I; Sandberg R; Grabherr M; Andersson B; Simon A
Article: NATURE PROTOCOLS. 2017;12(12):2531-2553
Multimodal profiling of single-cell morphology, electrophysiology, and gene expression using Patch-seq
Cadwell CR; Scala F; Li S; Livrizzi G; Shen S; Sandberg R; Jiang X; Tolias AS
Article: EMBO JOURNAL. 2017;36(14):2107-2125
A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover
Malenczyk K; Girach F; Szodorai E; Storm P; Segerstolpe A; Tortoriello G; Schnell R; Mulder J; Romanov RA; Borok E; Piscitelli F; Di Marzo V; Szabo G; Sandberg R; Kubicek S; Lubec G; Hokfelt T; Wagner L; Groop L; Harkany T
Article: NATURE MEDICINE. 2017;23(6):692-702
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Giustacchini A; Thongjuea S; Barkas N; Woll PS; Povinelli BJ; Booth CAG; Sopp P; Norfo R; Rodriguez-Meira A; Ashley N; Jamieson L; Vyas P; Anderson K; Segerstolpe A; Qian H; Olsson-Stromberg U; Mustjoki S; Sandberg R; Jacobsen SEW; Mead AJ
Article: ELIFE. 2017;6:e22906
Position-and Hippo signaling -dependent plasticity during lineage segregation in the early mouse embryo
Posfai E; Petropoulos S; de Barrosl FRO; Schell JP; Jurisica I; Sandberg R; Lanner F; Rossant J
Article: CELL STEM CELL. 2017;20(1):29-40
Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages
Kee N; Volakakis N; Kirkeby A; Dahl L; Storvall H; Nolbrant S; Lahti L; Bjorklund AK; Gillberg L; Joodmardi E; Sandberg R; Parmar M; Perlmann T
Article: NATURE BIOTECHNOLOGY. 2016;34(12):1264-1266
Single-cell sequencing of the small-RNA transcriptome
Faridani OR; Abdullayev I; Hagemann-Jensen M; Schell JP; Lanner F; Sandberg R
Article: NATURE IMMUNOLOGY. 2016;17(12):1424-1435
Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
Luis TC; Luc S; Mizukami T; Boukarabila H; Thongjuea S; Woll PS; Azzoni E; Giustacchini A; Lutteropp M; Bouriez-Jones T; Vaidya H; Mead AJ; Atkinson D; Boiers C; Carrelha J; Macaulay IC; Patient R; Geissmann F; Nerlov C; Sandberg R; de Bruijn MFTR; Blackburn CC; Godin I; Jacobsen SEW
Article: NATURE GENETICS. 2016;48(11):1430-1435
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
Article: CELL METABOLISM. 2016;24(4):593-607
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Segerstolpe A; Palasantza A; Eliasson P; Andersson E-M; Andreasson A-C; Sun X; Picelli S; Sabirsh A; Clausen M; Bjursell MK; Smith DM; Kasper M; Ammala C; Sandberg R
Article: BIOINFORMATICS. 2016;32(19):3038-3040
scphaser: haplotype inference using single-cell RNA-seq data
Edsgard D; Reinius B; Sandberg R
Article: GENOME RESEARCH. 2016;26(10):1342-1354
Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
Chen G; Schell JP; Benitez JA; Petropoulos S; Yilmaz M; Reinius B; Alekseenko Z; Shi L; Hedlund E; Lanner F; Sandberg R; Deng Q
Article: NATURE COMMUNICATIONS. 2016;7:12139
Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling
Nichterwitz S; Chen G; Benitez JA; Yilmaz M; Storvall H; Cao M; Sandberg R; Deng Q; Hedlund E
Article: CELL. 2016;165(4):1012-1026
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
Article: NATURE IMMUNOLOGY. 2016;17(4):451-460
The heterogeneity of human CD127⁺ innate lymphoid cells revealed by single-cell RNA sequencing
Bjorklund AK; Forkel M; Picelli S; Konya V; Theorell J; Friberg D; Sandberg R; Mjosberg J
Article: NATURE BIOTECHNOLOGY. 2016;34(2):199-203
Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq
Cadwell CR; Palasantza A; Jiang X; Berens P; Deng Q; Yilmaz M; Reimer J; Shen S; Bethge M; Tolias KF; Sandberg R; Tolias AS
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Haegglund H; Mattsson M; Lentio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Article: BREAST CANCER RESEARCH. 2015;17(1):109
Decoding breast cancer tissue-stroma interactions using species-specific sequencing
Chivukula IV; Ramskold D; Storvall H; Anderberg C; Jin S; Mamaeva V; Sahlgren C; Pietras K; Sandberg R; Lendahl U
Article: GENOME BIOLOGY. 2015;16(1):156
Genome-wide mapping of promoter-anchored interactions with close to single-enhancer resolution
Sahlen P; Abdullayev I; Ramskold D; Matskova L; Rilakovic N; Lotstedt B; Albert TJ; Lundeberg J; Sandberg R
Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(5):E230-E241
Novel functions and targets of miR-944 in human cervical cancer cells
Xie H; Lee L; Scicluna P; Kavak E; Larsson C; Sandberg R; Lui W-O
Article: GENOME RESEARCH. 2014;24(12):2033-2040
Tn5 transposase and tagmentation procedures for massively scaled sequencing projects
Picelli S; Bjorklund AK; Reinius B; Sagasser S; Winberg G; Sandberg R
Article: CELL STEM CELL. 2014;15(5):619-633
BMP Signaling and Its pSMAD1/5 Target Genes Differentially Regulate Hair Follicle Stem Cell Lineages
Genander M; Cook PJ; Ramskold D; Keyes BE; Mertz AF; Sandberg R; Fuchs E
Article: CANCER CELL. 2014;25(6):794-808
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
Woll PS; Kjallquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstrom-Lindberg E; Linnarsson S; Jacobsen SEW
Article: CANCER DISCOVERY. 2014;4(4):434-451
RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma
Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Hellman U; Sandberg R; Kenchappa RS; Martinson T; Johnsen JI; Kogner P; Schlisio S
Article: NATURE PROTOCOLS. 2014;9(1):171-181
Full-length RNA-seq from single cells using Smart-seq2
Picelli S; Faridani OR; Bjorklund AK; Winberg G; Sagasser S; Sandberg R
Article: NATURE METHODS. 2014;11(1):22-24
Entering the era of single-cell transcriptomics in biology and medicine
Sandberg R
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2013;20(12):1367-1376
The human cap-binding complex is functionally connected to the nuclear RNA exosome
Andersen PR; Domanski M; Kristiansen MS; Storvall H; Ntini E; Verheggen C; Schein A; Bunkenborg J; Poser I; Hallais M; Sandberg R; Hyman A; LaCava J; Rout MP; Andersen JS; Bertrand E; Jensen TH
Article: CELL STEM CELL. 2013;13(5):535-548
Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells
Boiers C; Carrelha J; Lutteropp M; Luc S; Green JCA; Azzoni E; Woll PS; Mead AJ; Hultquist A; Swiers G; Perdiguero EG; Macaulay IC; Melchiori L; Luis TC; Kharazi S; Bouriez-Jones T; Deng Q; Ponten A; Atkinson D; Jensen CT; Sitnicka E; Geissmann F; Godin I; Sandberg R; de Bruijn MFTR; Jacobsen SEW
Article: ONCOGENE. 2013;32(41):4892-4902
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKb
Jin S; Mutvei AP; Chivukula IV; Andersson ER; Ramskold D; Sandberg R; Lee KL; Kronqvist P; Mamaeva V; Ostling P; Mpindi J-P; Kallioniemi O; Screpanti I; Poellinger L; Sahlgren C; Lendahl U
Article: EXPERIMENTAL CELL RESEARCH. 2013;319(8):1187-1197
A reference transcriptome and inferred proteome for the salamander Notophthalmus viridescens
Abdullayev I; Kirkham M; Bjorklund AK; Simon A; Sandberg R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(18):7330-7335
SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals
Oosterveen T; Kurdija S; Enstero M; Uhde CW; Bergsland M; Sandberg M; Sandberg R; Muhr J; Ericson J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2360-2365
Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
Kadkhodaei B; Alvarsson A; Schintu N; Ramskold D; Volakakis N; Joodmardi E; Yoshitake T; Kehr J; Decressac M; Bjorklund A; Sandberg R; Svenningsson P; Perlmann T
Article: PLOS ONE. 2013;8(1):e53822
Efficient and Comprehensive Representation of Uniqueness for Next-Generation Sequencing by Minimum Unique Length Analyses
Storvall H; Ramskold D; Sandberg R
Article: BMC GENOMICS. 2012;13:607
Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome
Reinius B; Johansson MM; Radomska KJ; Morrow EH; Pandey GK; Kanduri C; Sandberg R; Williams RW; Jazin E
Article: NATURE BIOTECHNOLOGY. 2012;30(8):777-782
Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells
Ramskold D; Luo S; Wang Y-C; Li R; Deng Q; Faridani OR; Daniels GA; Khrebtukova I; Loring JF; Laurent LC; Schroth GP; Sandberg R
Article: METHODS IN MOLECULAR BIOLOGY. 2012;802:259-274
How to analyze gene expression using RNA-sequencing data.
Ramsköld D; Kavak E; Sandberg R
Article: GENES & DEVELOPMENT. 2011;25(23):2453-2464
Sequentially acting Sox transcription factors in neural lineage development
Bergsland M; Ramskold D; Zaouter C; Klum S; Sandberg R; Muhr J
Article: NATURE. 2011;479(7371):74-79
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
Shukla S; Kavak E; Gregory M; Imashimizu M; Shutinoski B; Kashlev M; Oberdoerffer P; Sandberg R; Oberdoerffer S
Article: CELL STEM CELL. 2011;8(6):663-675
Transcription Factor-Induced Lineage Selection of Stem-Cell-Derived Neural Progenitor Cells
Panman L; Andersson E; Alekseenko Z; Hedlund E; Kee N; Mong J; Uhde CW; Deng Q; Sandberg R; Stanton LW; Ericson J; Perlmann T
Article: PLOS COMPUTATIONAL BIOLOGY. 2009;5(12):e1000598
An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data
Ramskold D; Wang ET; Burge CB; Sandberg R
Article: NATURE. 2008;456(7221):470-476
Alternative isoform regulation in human tissue transcriptomes
Wang ET; Sandberg R; Luo S; Khrebtukova I; Zhang L; Mayr C; Kingsmore SF; Schroth GP; Burge CB
Article: SCIENCE. 2008;320(5883):1643-1647
Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites
Sandberg R; Neilson JR; Sarma A; Sharp PA; Burge CB
Article: RNA: A PUBLICATION OF THE RNA SOCIETY. 2007;13(11):1894-1910
Determinants of targeting by endogenous and exogenous microRNAs and siRNAs
Nielsen CB; Shomron N; Sandberg R; Hornstein E; Kitzman J; Burge CB
Article: BMC BIOINFORMATICS. 2007;8:48
Improved precision and accuracy for microarrays using updated probe set definitions
Sandberg R; Larsson O
Article: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2006;10(3):381-397
Comparative microarray analysis
Larsson O; Wennmalm K; Sandberg R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(6):2052-2057
Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI)
Sandberg R; Ernberg I
Article: GENOME BIOLOGY. 2005;6(8):R65
The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles -: art. no. r65
Sandberg R; Ernberg I
Article: GENE. 2003;311:35-42
Quantifying the species-specificity in genomics signatures, synonymous codon choice, amino acid usage and G+C content
Sandberg R; Bränden CI; Ernberg I; Cöster J
Article: GENOME RESEARCH. 2001;11(8):1404-1409
Capturing whole-genome characteristics in short sequences using a naive Bayesian classifier
Sandberg R; Winberg G; Bränden CI; Kaske A; Ernberg I; Cöster J
Article: MICROBIOLOGY (UNITED KINGDOM). 2000;146:2665-2670
Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer
Good L; Sandberg R; Larsson O; Nielsen PE; Wahlestedt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(20):11038-11043
Regional and strain-specific gene expression mapping in the adult mouse brain
Sandberg R; Yasuda R; Pankratz DG; Carter TA; Del Rio JA; Wodicka L; Mayford M; Lockhart DJ; Barlow C
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Letter: CELL RESEARCH. 2023;33(11):883-886
Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells
Stralin KB; Carrelha J; Winroth A; Ziegenhain C; Hagemann-Jensen M; Kettyle LM; Hillen A; Hogstrand K; Markljung E; Grasso F; Seki M; Mazzi S; Meng Y; Wu B; Chari E; Lehander M; Sandberg R; Woll PS; Jacobsen SEW
Editorial comment: NATURE METHODS. 2022;19(5):530-531
Novel spike-ins for single-cell sequencing enable ground-truth RNA counting
Ziegenhain C; Sandberg R
Corrigendum: NATURE BIOTECHNOLOGY. 2020;38(3):374
Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells (vol 87, pg 123, 2012)
Ramskold D; Luo S; Wang Y-C; Li R; Deng Q; Faridani OR; Daniels GA; Khrebtukova I; Loring JF; Laurent LC; Schroth GP; Sandberg R
Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):5075
Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas (vol 10, 4174, 2019)
Scala F; Kobak D; Shan S; Bernaerts Y; Laturnus S; Cadwell CR; Hartmanis L; Froudarakis E; Castro JR; Tan ZH; Papadopoulos S; Patel SS; Sandberg R; Berens P; Jiang X; Tolias AS
Letter: NATURE GENETICS. 2018;50(9):1199-1200
Reply to 'High prevalence of clonal monoallelic expression'
Reinius B; Sandberg R
Letter: NATURE METHODS. 2018;15(5):305-307
Computational correction of index switching in multiplexed sequencing libraries
Larsson AJM; Stanley G; Sinha R; Weissman IL; Sandberg R
Editorial comment: BMC BIOLOGY. 2017;15(1):58
Q&A: using Patch-seq to profile single cells
Cadwell CR; Sandberg R; Jiang X; Tolias AS
Corrigendum: CELL. 2016;167(1):285
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos (vol 165, pg 1012, 2016)
Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
Corrigendum: NATURE IMMUNOLOGY. 2016;17(6):740
The heterogeneity of human CD127⁺ innate lymphoid cells revealed by single-cell RNA sequencing (vol 17, pg 451, 2016)
Bjorklund AK; Forkel M; Picelli S; Konya V; Theorell J; Friberg D; Sandberg R; Mjosberg J
Editorial comment: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2016;71(1):29-30
Adult Human and Mouse Ovaries Lack DDX4-Expressing Functional Oogonial Stem Cells EDITORIAL COMMENT
Zhang H; Panula S; Petropoulos S; Edsgard D; Busayavalasa K; Liu L; Li X; Risal S; Shen Y; Shao J; Liu M; Li S; Zhang D; Zhang X; Gerner RR; Sheikhi M; Damdimopoulou P; Sandberg R; Douagi I; Gustafsson J-A; Liu L; Lanner F; Hovatta O; Liu K
Review: NATURE REVIEWS GENETICS. 2015;16(11):653-664
MODES OF TRANSCRIPTIONAL REGULATION Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation
Reinius B; Sandberg R
Letter: NATURE MEDICINE. 2015;21(10):1116-1118
Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
Zhang H; Panula S; Petropoulos S; Edsgard D; Busayavalasa K; Liu L; Li X; Risal S; Shen Y; Shao J; Liu M; Li S; Zhang D; Zhang X; Gerner RR; Sheikhi M; Damdimopoulou P; Sandberg R; Douagi I; Gustafsson J-A; Liu L; Lanner F; Hovatta O; Liu K
Editorial comment: NATURE BIOTECHNOLOGY. 2015;33(5):490-491
Putting cells in their place
Faridani OR; Sandberg R
Corrigendum: CANCER CELL. 2015;27(4):603-605
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)
Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Review: DEVELOPMENT. 2011;138(17):3593-3612
Notch signaling: simplicity in design, versatility in function
Andersson ER; Sandberg R; Lendahl U
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1357-1364
Heterogeneity in mammalian RNA 3′ end formation
Neilson JR; Sandberg R
Letter: NATURE BIOTECHNOLOGY. 2006;24(11):1322-1323
Lack of correct data format and comparability limits future integrative microarray research
Larsson O; Sandberg R
Review: SEMINARS IN CANCER BIOLOGY. 2005;15(5):405-412
Gene expression perturbation in vitro - A growing case for three-dimensional (3D) culture systems
Birgersdotter A; Sandberg R; Ernberg I
Thesis / dissertation: 2004
Analyses of genomic and gene expression signatures
Sandberg, Rickard
Editorial comment: GENOME RESEARCH. 2003;13(11):2377-2380
Systems biology is taking off
Ehrenberg M; Elf J; Aurell E; Sandberg R; Tegnér J

Forskningsbidrag

Sandberg, Rickard – Large-scale identification of direct transcriptional effects of anti-cancer drugs
Swedish Cancer Society
1 January 2022
Understand gene regulation through massively parallel single-cell genomics
Swedish Research Council
1 January 2018 - 31 December 2027
Deciphering the building blocks of hippocampal circuits
National Institute of Mental Health
1 September 2017 - 30 June 2024
Elucidating the principles of allelic expression and regulation using single-cell genomics
Knut and Alice Wallenberg Foundation
1 January 2017 - 1 January 2022
Single-Cell Gene Regulation in Differentiation and Pluripotency
Swedish Research Council
1 January 2013 - 31 December 2017

Anställningar

Professor, Cell- och molekylärbiologi, Karolinska Institutet, 2015-

Examina och utbildning

Docent, Bioinformatik, Karolinska Institutet, 2013
MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2004
LICENTIATEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2002
Medicine Magisterexamen, Karolinska Institutet, 2000

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