Karin Loré

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: EMERGING MICROBES AND INFECTIONS. 2024;13(1):2309985
Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques
Huang L; Zhao T; Zhao W; Shao A; Zhao H; Ma W; Gong Y; Zeng X; Weng C; Bu L; Di Z; Sun S; Dai Q; Sun M; Wang L; Liu Z; Shi L; Hu J; Fang S; Zhang C; Zhang J; Wang G; Lore K; Yang Y; Lin A
Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2023;1524(1):65-86
Progress in vaccine development for infectious diseases-a Keystone Symposia report
Cable J; Graham BS; Koup RA; Seder RA; Kariko K; Pardi N; Barouch DH; Sharma B; Rauch S; Nachbagauer R; Forsell MNE; Schotsaert M; Ellebedy AH; Lore K; Irvine DJ; Pilkington E; Tahtinen S; Thompson EA; Feraoun Y; King NP; Saunders K; Alter G; Moin SM; Sliepen K; Karlsson Hedestam GB; Wardemann H; Pulendran B; Doria-Rose NA; He W-T; Juno JA; Ataca S; Wheatley AK; McLellan JS; Walker LM; Lederhofer J; Lindesmith LC; Wille H; Hotez PJ; Bekker L-G
Article: NATURE COMMUNICATIONS. 2023;14(1):2164
Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19
Yu M; Charles A; Cagigi A; Christ W; osterberg B; Falck-Jones S; Azizmohammadi L; ahlberg E; Falck-Jones R; Svensson J; Nie M; Warnqvist A; Hellgren F; Lenart K; Arcoverde Cerveira R; Ols S; Lindgren G; Lin A; Maecker H; Bell M; Johansson N; Albert J; Sundling C; Czarnewski P; Klingstroem J; Faernert A; Lore K; Smed-Soerensen A
Article: PLOS NEGLECTED TROPICAL DISEASES. 2023;17(2):e0010616
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial.
Sandberg JT; Löfling M; Varnaitė R; Emgård J; Al-Tawil N; Lindquist L; Gredmark-Russ S; Klingström J; Loré K; Blom K; Ljunggren H-G
Article: MOLECULAR THERAPY: METHODS & CLINICAL DEVELOPMENT. 2022;27:309-323
A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses
Lenart K; Hellgren F; Ols S; Yan X; Cagigi A; Cerveira RA; Winge I; Hanczak J; Mueller SO; Jasny E; Schwendt K; Rauch S; Petsch B; Lore K
Article: IMMUNITY. 2022;55(9):1732-1746.e5
Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
Gao Y; Cai C; Wullimann D; Niessl J; Rivera-Ballesteros O; Chen P; Lange J; Cuapio A; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Perez-Potti A; Sekine T; Muller TR; Boulouis C; Kammann T; Parrot T; Muvva JR; Sobkowiak M; Healy K; Bogdanovic G; Muschiol S; Soderdahl G; Osterborg A; Hellgren F; Grifoni A; Weiskopf D; Sette A; Lore K; Chen MS; Ljungman P; Sandberg JK; Smith CIE; Bergman P; Ljunggren H-G; Aleman S; Buggert M
Article: MED. 2022;3(2):137-153.e3
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals
Healy K; Pin E; Chen P; Soderdahl G; Nowak P; Mielke S; Hansson L; Bergman P; Smith CIE; Ljungman P; Valentini D; Blennow O; Osterborg A; Gabarrini G; Al-Manei K; Alkharaan H; Sobkowiak MJ; Yousef J; Mravinacova S; Cuapio A; Xu X; Akber M; Lore K; Hellstrom C; Muschiol S; Bogdanovic G; Buggert M; Ljunggren H-G; Hober S; Nilsson P; Aleman S; Chen MS
Article: MOLECULAR MEDICINE. 2022;28(1):20
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals
Cuapio A; Boulouis C; Filipovic I; Wullimann D; Kammann T; Parrot T; Chen P; Akber M; Gao Y; Hammer Q; Strunz B; Potti AP; Ballesteros OR; Lange J; Muvva JR; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Soderdahl G; Osterborg A; Smith CIE; Bogdanovic G; Muschiol S; Hellgren F; Lore K; Sobkowiak MJ; Gabarrini G; Healy K; Chen MS; Alici E; Bjorkstrom NK; Buggert M; Ljungman P; Sandberg JK; Aleman S; Ljunggren H-G
Article: EBIOMEDICINE. 2021;74:103705
Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial
Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Chen P; Soderdahl G; Osterborg A; Smith CIE; Wullimann D; Vesterbacka J; Lindgren G; Blixt L; Friman G; Wahren-Borgstrom E; Nordlander A; Gomez AC; Akber M; Valentini D; Norlin A-C; Thalme A; Bogdanovic G; Muschiol S; Nilsson P; Hober S; Lore K; Chen MS; Buggert M; Ljunggren H-G; Ljungman P; Aleman S
Article: JCI INSIGHT. 2021;6(22):e151463
Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination
Cagigi A; Yu M; Osterberg B; Svensson J; Falck-Jones S; Vangeti S; Ahlberg E; Azizmohammadi L; Warnqvist A; Falck-Jones R; Gubisch PC; Odemis M; Ghafoor F; Eisele M; Lenart K; Bell M; Johansson N; Albert J; Salde J; Pettie DD; Murphy MP; Carter L; King NP; Ols S; Normark J; Ahlm C; Forsell MN; Farnert A; Lore K; Smed-Sorensen A
Article: IMMUNITY. 2021;54(9):2005-2023.e10
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response
Glaros V; Rauschmeier R; Artemov AV; Reinhardt A; Ols S; Emmanouilidi A; Gustafsson C; You Y; Mirabello C; Bjorklund AK; Perez L; King NP; Mansson R; Angeletti D; Lore K; Adameyko I; Busslinger M; Kreslavsky T
Article: JOURNAL OF IMMUNOLOGY. 2021;207(4):1033-1043
Activation and Kinetics of Circulating T Follicular Helper Cells, Specific Plasmablast Response, and Development of Neutralizing Antibodies following Yellow Fever Virus Vaccination
Sandberg JT; Ols S; Lofling M; Varnait R; Lindgren G; Nilsson O; Rombo L; Kale M; Lore K; Blom K; Ljunggren H-G; Lindgren G; Nilsson O; Rombo L; Kale M
Article: CELL REPORTS MEDICINE. 2021;2(4):100252
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(6):144734
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity
Falck-Jones S; Vangeti S; Yu M; Falck-Jones R; Cagigi A; Badolati I; Osterberg B; Lautenbach MJ; Ahlberg E; Lin A; Lepzien R; Szurgot I; Lenart K; Hellgren F; Maecker H; Salde J; Albert J; Johansson N; Bell M; Lore K; Farnert A; Smed-Sorensen A
Article: NATURE COMMUNICATIONS. 2021;12(1):1510
Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain
Kupari J; Usoskin D; Parisien M; Lou D; Hu Y; Fatt M; Lonnerberg P; Spangberg M; Eriksson B; Barkas N; Kharchenko PV; Lore K; Khoury S; Diatchenko L; Ernfors P
Article: METHODS IN MOLECULAR BIOLOGY. 2021;2236:9-17
Phenotyping of Myeloid-Derived Suppressor Cells in Nonhuman Primates.
Lin A; Loré K
Article: ELIFE. 2020;9:e60528
A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites
Bhandage AK; Olivera GC; Kanatani S; Thompson E; Lore K; Varas-Godoy M; Barragan A
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2020;8(2):e001223
Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
Cassetta L; Bruderek K; Skrzeczynska-Moncznik J; Osiecka O; Hu X; Rundgren IM; Lin A; Santegoets K; Horzum U; Godinho-Santos A; Zelinskyy G; Garcia-Tellez T; Bjelica S; Taciak B; Kittang AO; Hoeing B; Lang S; Dixon M; Mueller V; Utikal JS; Karakoc D; Yilmaz KB; Gorka E; Bodnar L; Anastasiou OE; Bourgeois C; Badura R; Kapinska-Mrowiecka M; Gotic M; ter Laan M; Kers-Rebel E; Krol M; Santibanez JF; Mueller-Trutwin M; Dittmer U; de Sousa AE; Esendagli G; Adema G; Lore K; Ersvaer E; Umansky V; Pollard JW; Cichy J; Brandau S
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2020;481:112792
Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers
Silva MH; Lepzien R; Ols S; Dahlberg B; Grunewald J; Lore K; Smed-Sorensen A; Correia-Neves M; Empadinhas N; Farnert A; Kallenius G; Sundling C
Article: SCIENCE ADVANCES. 2020;6(19):eaaz2433
A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates
Stone VM; Hankaniemi MM; Laitinen OH; Sioofy-Khojine AB; Lin A; Lozano IMD; Mazur MA; Marjomaki V; Lore K; Hyoty H; Hytonen VP; Flodstrom-Tullberg M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(5):2332-2346
Live attenuated pertussis vaccine BPZE1 induces a broad antibody response in humans
Lin A; Apostolovic D; Jahnmatz M; Liang F; Ols S; Tecleab T; Wu C; van Hage M; Solovay K; Rubin K; Locht C; Thorstensson R; Thalen M; Lore K
Article: JOURNAL OF INFECTIOUS DISEASES. 2020;221(8):1295-1303
Recurrent Herpes Zoster Ophthalmicus in a Patient With a Novel Toll-Like Receptor 3 Variant Linked to Compromised Activation Capacity in Fibroblasts
Liang F; Glans H; Enoksson SL; Kolios AGA; Lore K; Nilsson J
Article: CELL REPORTS. 2020;30(12):3964-3971.e7
Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity
Ols S; Yang L; Thompson EA; Pushparaj P; Tran K; Liang F; Lin A; Eriksson B; Hedestam GBK; Wyatt RT; Lore K
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(7):e1150
Deficits in the IgG⁺ memory B-cell recovery after anthracycline treatment is confined to the spleen of rhesus macaques
Lasaviciute G; Bricaud AL; Hellgren F; Ingelman-Sundberg HM; Eksborg S; Jonker M; Haanstra KG; Hed Myrberg I; Sverremark-Ekstrom E; Lore K; Saghafian-Hedengren S; Nilsson A
Article: PLOS PATHOGENS. 2019;15(12):e1008121
ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type
Schifanella L; Barnett SW; Bissa M; Galli V; Doster MN; Vaccari M; Tomaras GD; Shen X; Phogat S; Pal R; Montefiori DC; LaBranche CC; Rao M; Trinh HV; Washington-Parks R; Liyanage NPM; Brown DR; Liang F; Lore K; Venzon DJ; Magnanelli W; Metrinko M; Kramer J; Breed M; Alter G; Ruprecht RM; Franchini G
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2019;472:16-24
Comparative analysis of the germinal center response by flow cytometry and immunohistology
Lindgren G; Ols S; Thompson EA; Lore K
Article: CELL REPORTS. 2019;28(5):1127-1135.e4
Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-β Release
Thompson EA; Darrah PA; Foulds KE; Hoffer E; Caffrey-Carr A; Norenstedt S; Perbeck L; Seder RA; Kedl RM; Lore K
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2019;68(4):687-697
Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates
Cassetta L; Baekkevold ES; Brandau S; Bujko A; Cassatella MA; Dorhoi A; Krieg C; Lin A; Lore K; Marini O; Pollard JW; Roussel M; Scapini P; Umansky V; Adema GJ
Article: CELL. 2019;176(6):1420-1431.e17
Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus
Marcandalli J; Fiala B; Ols S; Perotti M; de van der Schueren W; Snijder J; Hodge E; Benhaim M; Ravichandran R; Carter L; Sheffler W; Brunner L; Lawrenz M; Dubois P; Lanzavecchia A; Sallusto F; Lee KK; Veesler D; Correnti CE; Stewart LJ; Baker D; Lore K; Perez L; King NP
Article: JCI INSIGHT. 2018;3(10):120692
TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25
Thompson EA; Ols S; Miura K; Rausch K; Narum DL; Spangberg M; Juraska M; Wille-Reece U; Weiner A; Howard RF; Long CA; Duffy PE; Johnston L; O'neil CP; Lore K
Article: JOURNAL OF IMMUNOLOGY. 2018;200(1):286-294
Rhesus Macaque Myeloid-Derived Suppressor Cells Demonstrate T Cell Inhibitory Functions and Are Transiently Increased after Vaccination
Lin A; Liang F; Thompson EA; Vono M; Ols S; Lindgren G; Hassett K; Salter H; Ciaramella G; Lore K
Article: MOLECULAR THERAPY. 2017;25(12):2635-2647
Efficient Targeting and Activation of Antigen Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
Liang F; Lindgren G; Lin A; Thompson EA; Ols S; Rohss J; John S; Hassett K; Yuzhakov O; Bahl K; Brito LA; Salter H; Ciaramella G; Lore K
Article: SCIENCE TRANSLATIONAL MEDICINE. 2017;9(393):eaal2094
Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake
Liang F; Lindgren G; Sandgren KJ; Thompson EA; Francica JR; Seubert A; De Gregorio E; Barnett S; O'Hagan DT; Sullivan NJ; Koup RA; Seder RA; Lore K
Article: IMMUNITY. 2017;46(5):804-817.e7
Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
Martinez-Murillo P; Tran K; Guenaga J; Lindgren G; Adori M; Feng Y; Phad GE; Bernat NV; Bale S; Ingale J; Dubrovskaya V; O'Dell S; Pramanik L; Spangberg M; Corcoran M; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: BLOOD. 2017;129(14):1991-2001
Neutrophils acquire the capacity for antigen presentation to memory CD4⁺ T cells in vitro and ex vivo
Vono M; Lin A; Norrby-Teglund A; Koup RA; Liang F; Lore K
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1539
Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+CXCR3+T Follicular Helper Cells
Lindgren G; Ols S; Liang F; Thompson EA; Lin A; Hellgren F; Bahl K; John S; Yuzhakov O; Hassett KJ; Brito LA; Salter H; Ciaramella G; Lore K
Article: NATURE MEDICINE. 2016;22(7):762-770
Adjuvant-dependent innate and adaptive immune signatures of risk of SIV_mac251 acquisition
Vaccari M; Gordon SN; Fourati S; Schifanella L; Liyanage NPM; Cameron M; Keele BF; Shen X; Tomaras GD; Billings E; Rao M; Chung AW; Dowell KG; Bailey-Kellogg C; Brown EP; Ackerman ME; Vargas-Inchaustegui DA; Whitney S; Doster MN; Binello N; Pegu P; Montefiori DC; Foulds K; Quinn DS; Donaldson M; Liang F; Lore K; Roederer M; Koup RA; McDermott A; Ma Z-M; Miller CJ; Phan TB; Forthal DN; Blackburn M; Caccuri F; Bissa M; Ferrari G; Kalyanaraman V; Ferrari MG; Thompson D; Robert-Guroff M; Ratto-Kim S; Kim JH; Michael NL; Phogat S; Barnett SW; Tartaglia J; Venzon D; Stablein DM; Alter G; Sekaly R-P; Franchini G
Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2015;496(2):371-381
Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses
Salvador A; Sandgren KJ; Liang F; Thompson EA; Koup RA; Pedraz JL; Maria Hernandez R; Lore K; Igartua M
Journal article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3497-3498
Correction: Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates.
Thompson EA; Liang F; Lindgren G; Sandgren KJ; Quinn KM; Darrah PA; Koup RA; Seder RA; Kedl RM; Loré K
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2015;425:69-78
Dissociation of skeletal muscle for flow cytometric characterization of immune cells in macaques
Liang F; Ploquin A; Hernandez JD; Fausther-Bovendo H; Lindgren G; Stanley D; Salvador Martinez A; Brenchley JM; Koup RA; Lore K; Sullivan NJ
Article: JOURNAL OF IMMUNOLOGY. 2015;195(3):1015-1024
Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates
Thompson EA; Liang F; Lindgren G; Sandgren KJ; Quinn KM; Darrah PA; Koup RA; Seder RA; Kedl RM; Lore K
Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30(S1):a64-a65
Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition
Vaccari M; Gordon SN; Fourati S; Schifanella L; Cameron M; Keele BF; Shen X; Tomaras G; Billings E; Rao M; Liyanage NPM; Vargas-Inchaustegui DA; Whitney S; Doster MN; Binello N; Pegu P; Montefiori DC; Foulds K; Quinn DS; Donaldson M; Liang F; Lore K; Roederer M; Koup R; McDermott A; Ma Z-M; Christopher M; Phan TB; Forthal DN; Blackburn M; Caccuri F; Ferrari G; Robert-Guroff M; Ratto-Kim S; Kim J; Michael N; Phogat S; Barnett SW; Tartaglia J; Venzon D; Stablein DM; Sekaly R-P; Franchini G
Article: IMMUNITY. 2014;41(3):493-502
Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells
Calantone N; Wu F; Klase Z; Deleage C; Perkins M; Matsuda K; Thompson EA; Ortiz AM; Vinton CL; Ourmanov I; Lore K; Douek DC; Estes JD; Hirsch VM; Brenchley JM
Journal article: CELL STEM CELL. 2014;14(4):486-499
Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.
Wu C; Li B; Lu R; Koelle SJ; Yang Y; Jares A; Krouse AE; Metzger M; Liang F; Loré K; Wu CO; Donahue RE; Chen ISY; Weissman I; Dunbar CE
Article: VACCINE. 2014;32(6):717-724
Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression
Johnson MJ; Bjorkstrom NK; Petrovas C; Liang F; Gall JGD; Lore K; Koup RA
Article: JOURNAL OF IMMUNOLOGY. 2013;191(10):5085-5096
Coadministration of Polyinosinic: Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity
Quinn KM; Yamamoto A; Costa A; Darrah PA; Lindsay RWB; Hegde ST; Johnson TR; Flynn BJ; Lore K; Seder RA
Article: VIROLOGY. 2013;446(1-2):56-65
Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants
Feng Y; Forsell MNE; Flynn B; Adams W; Lore K; Seder R; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):60-69
Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation
Sandgren KJ; Smed-Sorensen A; Forsell MN; Soldemo M; Adams WC; Liang F; Perbeck L; Koup RA; Wyatt RT; Hedestam GBK; Lore K
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70
AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment
Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Lore K; Winqvist O; Chambers BJ; Karlsson MCI
Article: AIDS. 2013;27(7):1071-1080
Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration
Liang F; Bond E; Sandgren KJ; Smed-Sorensen A; Rangaka MX; Lange C; Koup RA; McComsey GA; Lederman MM; Wilkinson RJ; Andersson J; Lore K
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2013;762:263-288
Targeting Dendritic Cells for Improved HIV-1 Vaccines
Smed-Sorensen A; Lore K
Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6109-6118
Type I IFN Induced by Adenovirus Serotypes 28 and 35 Has Multiple Effects on T Cell Immunogenicity
Johnson MJ; Petrovas C; Yamamoto T; Lindsay RWB; Lore K; Gall JGD; Gostick E; Lefebvre F; Cameron MJ; Price DA; Haddad E; Sekaly R-P; Seder RA; Koup RA
Article: JOURNAL OF GENERAL VIROLOGY. 2012;93(Pt 6):1339-1344
Attenuation of CD4⁺ T-cell function by human adenovirus type 35 is mediated by the knob protein
Adams WC; Berenson RJ; Hedestam GBK; Lieber A; Koup RA; Lore K
Article: METHODS IN MOLECULAR BIOLOGY. 2012;820:215-230
In vitro stimulation and detection of IFNα production in human plasmacytoid dendritic cells.
Adams WC; Loré K
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(1):114-123
Plasmacytoid Dendritic Cells Infiltrate the Skin in Positive Tuberculin Skin Test Indurations
Bond E; Liang F; Sandgren KJ; Smed-Sorensen A; Bergman P; Brighenti S; Adams WC; Betemariam SA; Rangaka MX; Lange C; Wilkinson RJ; Andersson J; Lore K
Article: IMMUNOLOGY. 2011;134(3):257-269
Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation
Gujer C; Sundling C; Seder RA; Hedestam GBK; Lore K
Article: CURRENT OPINION IN HIV AND AIDS. 2011;6(5):405-410
Dendritic cells at the interface of innate and adaptive immunity to HIV-1
Smed-Sorensen A; Lore K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(18):7499-7504
Adenovirus type-35 vectors block human CD4⁺ T-cell activation via CD46 ligation
Adams WC; Gujer C; McInerney G; Gall JGD; Petrovas C; Hedestam GBK; Koup RA; Lore K
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2011;89(6):811-821
IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naive B cell differentiation
Gujer C; Sandgren KJ; Douagi I; Adams WC; Sundling C; Smed-Sorensen A; Seder RA; Hedestam GBK; Lore K
Journal article: CLINICAL NUTRITION. 2011;6(1):109
PP226-SUN FISH OIL DOES NOT MODULATE THE RESPONSE OF IN VIVO PROTEIN SYNTHESIS IN IMMUNE CELLS TO ENDOTOXIN IN HEALTHY VOLUNTEERS
Januszkiewicz A; Claude M; Concha H; Hebert C; Lore K; Andersson J; Rooyackers O; Wernerman J
Article: JOURNAL OF VIROLOGY. 2010;84(18):9086-9095
Immunization with Wild-Type or CD4-Binding-Defective HIV-1 Env Trimers Reduces Viremia Equivalently following Heterologous Challenge with Simian-Human Immunodeficiency Virus
Sundling C; O'Dell S; Douagi I; Forsell MN; Morner A; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(9):2003-2017
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
Article: JOURNAL OF VIROLOGY. 2010;84(4):1683-1695
Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates
Douagi I; Forsell MNE; Sundling C; O'Dell S; Feng Y; Dosenovic P; Li Y; Seder R; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2009;183(6):4047-4054
Neutrophil-Derived Hyperresistinemia in Severe Acute Streptococcal Infections
Johansson L; Linner A; Sunden-Cullberg J; Haggar A; Herwald H; Lore K; Treutiger C-J; Norrby-Teglund A
Article: CURRENT OPINION IN HIV AND AIDS. 2009;4(5):441-446
Novel adjuvants for B cell immune responses
Lore K; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2009;348(1-2):42-56
Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity
Bond E; Adams WC; Smed-Sorensen A; Sandgren KJ; Perbeck L; Hofmann A; Andersson J; Lore K
Article: JOURNAL OF GENERAL VIROLOGY. 2009;90(Pt 7):1600-1610
Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN
Adams WC; Bond E; Havenga MJE; Holterman L; Goudsmit J; Hedestam GBK; Koup RA; Lore K
Article: INFECTION AND IMMUNITY. 2009;77(4):1679-1688
The Toxoplasma gondii-Shuttling Function of Dendritic Cells Is Linked to the Parasite Genotype
Lambert H; Vutova PP; Adams WC; Lore K; Barragan A
Article: JOURNAL OF IMMUNOLOGY. 2009;182(4):1991-2001
Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells
Douagi I; Gujer C; Sundling C; Adams WC; Smed-Soerensen A; Seder RA; Hedestam GBK; Lore K
Article: BLOOD. 2008;111(10):5037-5046
IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcγRIIa
Smed-Sorensen A; Moll M; Cheng T-Y; Lore K; Norlin A-C; Perbeck L; Moody DB; Spetz A-L; Sandberg JK
Article: JOURNAL OF VIROLOGY. 2007;81(24):13486-13498
Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection
Duvall MG; Lore K; Blaak H; Ambrozak DA; Adams WC; Santos K; Geldmacher C; Mascola JR; McMichael AJ; Jaye A; Whittle HC; Rowland-Jones SL; Koup RA
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2007;27(6):589-597
Enhanced In vivo protein synthesis in circulating immune cells of ICU patients
Januszkiewicz A; Klaude M; Lore K; Andersson J; Ringden O; Rooyackers O; Wernerman J
Article: JOURNAL OF IMMUNOLOGY. 2007;179(3):1721-1729
Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses
Lore K; Adams WC; Havenga MJE; Precopio ML; Holterman L; Goudsmit J; Koup RA
Article: BLOOD. 2007;110(1):441-449
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
Seggewiss R; Loré K; Guenaga FJ; Pittaluga S; Mattapallil J; Chow CK; Koup RA; Camphausen K; Nason MC; Meier-Schellersheim M; Donahue RE; Blazar BR; Dunbar CE; Douek DC
Article: STEM CELLS. 2006;24(6):1539-1548
In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques.
Loré K; Seggewiss R; Guenaga FJ; Pittaluga S; Donahue RE; Krouse A; Metzger ME; Koup RA; Reilly C; Douek DC; Dunbar CE
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2006;203(5):1249-1258
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates.
Wille-Reece U; Flynn BJ; Loré K; Koup RA; Miles AP; Saul A; Kedl RM; Mattapallil JJ; Weiss WR; Roederer M; Seder RA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(42):15190-15194
HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.
Wille-Reece U; Flynn BJ; Loré K; Koup RA; Kedl RM; Mattapallil JJ; Weiss WR; Roederer M; Seder RA
Article: JOURNAL OF VIROLOGY. 2005;79(14):8861-8869
Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells
Smed-Sörensen A; Loré K; Vasudevan J; Louder MK; Andersson J; Mascola JR; Spetz AL; Koup RA
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2005;201(12):2023-2033
Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4⁺ T cells
Loré K; Smed-Sörensen A; Vasudevan J; Mascola JR; Koup RA
Article: BLOOD. 2005;105(6):2473-2479
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.
Seggewiss R; Loré K; Greiner E; Magnusson MK; Price DA; Douek DC; Dunbar CE; Wiestner A
Article: CLINICAL SCIENCE. 2005;108(2):179-184
Determination of in vivo protein synthesis in human palatine tonsil
Januszkiewicz A; Klaude M; Loré K; Andersson J; Ringdén O; Rooyackers O; Wernerman J
Journal article: BLOOD. 2004;104(11):1342
Proliferation of CD8+ T-Cells Specific for CMV and EBV in Response to TCR Mediated Recognition of Cognate Antigen Is Inhibited by Imatinib in a Dose-Dependent Manner.
Seggewiss R; Lore K; Greiner E; Magnusson MK; Price DA; Douek DC; Dunbar CE; Wiestner A
Journal article: BLOOD. 2004;104(11):1196
In Vitro Culture during Retroviral Transduction Improves Thymic Repopulation and Output after TBI and Autologous PBPC Transplantation in Rhesus Macaques.
Seggewiss R; Lore K; Guenaga JF; Pittaluga S; Metzger ME; Krouse A; Donahue RE; Ambrozak D; Douek DC; Dunbar CE
Article: JOURNAL OF VIROLOGY. 2004;78(21):11980-11987
Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies.
Ganesh L; Leung K; Loré K; Levin R; Panet A; Schwartz O; Koup RA; Nabel GJ
Article: BLOOD. 2004;104(9):2810-2817
HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation
Smed-Sörensen A; Loré K; Walther-Jallow L; Andersson J; Spetz AL
Article: JOURNAL OF IMMUNOLOGY. 2004;172(10):6407-6417
The functional profile of primary human antiviral CD8⁺ T cell effector activity is dictated by cognate peptide concentration
Betts MR; Price DA; Brenchley JM; Loré K; Guenaga FJ; Smed-Sorensen A; Ambrozak DR; Migueles SA; Connors M; Roederer M; Douek DC; Koup RA
Article: JOURNAL OF IMMUNOLOGY. 2004;172(4):2219-2224
HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters.
Sugaya M; Loré K; Koup RA; Douek DC; Blauvelt A
Article: JOURNAL OF MEDICAL PRIMATOLOGY. 2004;33(1):16-24
Dichotomy between CD1a+ and CD83+ dendritic cells in lymph nodes during SIV infection of macaques
Söderlund J; Nilsson C; Loré K; Castanos-Velez E; Ekman M; Heiden T; Biberfeld G; Andersson J; Biberfeld P
Article: METHODS IN MOLECULAR BIOLOGY. 2004;249:201-218
Detection of cytokine- and chemokine-expressing cells at the single cell level.
Loré K; Andersson J
Article: JOURNAL OF IMMUNOLOGY. 2003;171(8):4320-4328
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses.
Loré K; Betts MR; Brenchley JM; Kuruppu J; Khojasteh S; Perfetto S; Roederer M; Seder RA; Koup RA
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2002;130(2):263-270
Response of in vivo protein synthesis in T lymphocytes and leucocytes to an endotoxin challenge in healthy volunteers
Januszkiewicz A; Loré K; Essén P; Andersson B; McNurlan MA; Garlick PJ; Ringdén O; Andersson J; Wernerman J
Article: AIDS. 2002;16(5):683-692
Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection
Loré K; Sönnerborg A; Broström C; Goh LE; Perrin L; McDade H; Stellbrink HJ; Gazzard B; Weber R; Napolitano LA; van Kooyk Y; Andersson J
Article: JOURNAL OF VIROLOGY. 2001;75(17):8195-8202
Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy
Lane BR; Lore K; Bock PJ; Andersson J; Coffey MJ; Strieter RM; Markovitz DM
Article: PEDIATRIC DERMATOLOGY. 2001;18(3):177-187
Erythema toxicum neonatorum:: An immunohistochemical analysis
Marchini G; Ulfgren AK; Loré K; Ståbi B; Berggren V; Lonne-Rahm S
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2001;249(1-2):207-222
Quantitative single cell methods that identify cytokine and chemokine expression in dendritic cells
Loré K; Spetz AL; Fehniger TE; Sönnerborg A; Landay AL; Andersson J
Article: AIDS. 1999;13(15):2013-2021
HIV-1 exposed dendritic cells show increased pro-inflammatory cytokine production but reduced IL-1ra following lipopolysaccharide stimulation
Loré K; Sönnerborg A; Olsson J; Patterson BK; Fehniger TE; Perbeck L; Andersson J
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1999;15(14):1249-1254
Long-term effects of antiretroviral combination therapy on HIV type 1 DNA levels
Aleman S; Visco-Comandini U; Loré K; Sönnerborg A
Article: AIDS. 1999;13(11):1295-1303
Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection
Andersson J; Behbahani H; Lieberman J; Connick E; Landay A; Patterson B; Sönnerborg A; Loré K; Uccini S; Fehniger TE
Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):736-742
Functional gene transfer of HIV DNA by an HIV receptor-independent mechanism
Spetz AL; Patterson BK; Lore K; Andersson J; Holmgren L
Article: CLINICAL MICROBIOLOGY AND INFECTION (CMI). 1999;5(2):78-87
Determination of cytomegalovirus DNA load for monitoring of cytomegalovirus disease and antiviral treatment in solid organ transplant patients, comparing limiting-dilution PCR and hybrid capture assay with cytomegalovirus isolation.
Barkholt L; Loré K; Tydén G; Lewensohn-Fuchs I; Andersson J; Ericzon B-G; Lundgren G; Ehrnst A
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 1998;214(1-2):97-111
Immunocytochemical detection of cytokines and chemokines in Langerhans cells and in vitro derived dendritic cells
Loré K; Sönnerborg A; Spetz AL; Andersson U; Andersson J
Article: BONE MARROW TRANSPLANTATION. 1996;17(4):583-587
Use of a semi-quantitative PCR for cytomegalovirus DNA as a basis for pre-emptive antiviral therapy in allogeneic bone marrow transplant patients
Ljungman P; Lore K; Aschan J; Klaesson S; LewensohnFuchs I; Lonnqvist B; Ringden O; Winiarski J; Ehrnst A
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Review: IMMUNITY. 2022;55(11):1993-2005
Innate immune mechanisms of mRNA vaccines
Verbeke R; Hogan MJ; Lore K; Pardi N
Review: JOURNAL OF INTERNAL MEDICINE. 2022;291(1):32-50
Immunity to SARS-CoV-2 induced by infection or vaccination
Castro Dopico X; Ols S; Lore K; Karlsson Hedestam GB
Review: VACCINES. 2021;9(1):61
Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
Cagigi A; Lore K
Preprint: MEDRXIV. 2020
Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity
Falck-Jones S; Vangeti S; Yu M; Falck-Jones R; Cagigi A; Badolati I; Österberg B; Lautenbach MJ; Åhlberg E; Lin A; Szurgot I; Lenart K; Hellgren F; Sälde J; Albert J; Johansson N; Bell M; Loré K; Färnert A; Smed-Sörensen A
Preprint: BIORXIV. 2020
SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses
Mandolesi M; Sheward D; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Loré K; Castro Dopico X; Coquet J; McInerney G; Karlsson Hedestam G; Murrell B
Editorial comment: NATURE BIOMEDICAL ENGINEERING. 2019;3(5):331-332
Imaging the early fate of mRNA vaccines
Ols S; Lore K
Corrigendum: FRONTIERS IN IMMUNOLOGY. 2019;10:614
Induction of Robust B Cell Responses After Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells (vol 8, 1539, 2017)
Lindgren G; Ols S; Liang F; Thompson EA; Lin A; Hellgren F; Bahl K; John S; Yuzhakov O; Hassett KJ; Brito LA; Salter H; Ciaramella G; Lore K
Book chapter: ENCYCLOPEDIA OF AIDS. 2018;p. 446-457
Dendritic Cell Interactions with HIV-1 Envelope Glycoprotein: Implications for Preventing Transmission
Sandgren KJ; Liang F; Smed-Sörensen A; Loré K
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2017;282(3):206-208
Prospects for induction of CD8 T cell-mediated immunity to Zika virus infection by yellow fever virus vaccination
Blom K; Sandberg JT; Lore K; Ljunggren H-G
Review: CURRENT OPINION IN IMMUNOLOGY. 2017;47:1-7
Non-human primates as a model for understanding the mechanism of action of toll-like receptor-based vaccine adjuvants
Thompson EA; Lore K
Review: FRONTIERS IN IMMUNOLOGY. 2017;8:1781
Granulocytes: New Members of the Antigen-Presenting Cell Family
Lin A; Lore K
Review: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2016;5(4):e74
Local innate immune responses in the vaccine adjuvant-injected muscle
Liang F; Lore K
Corrigendum: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(10):2283
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates (vol 207, pg 2003, 2010)
Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
Published conference paper: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2009;51(3):239-247
Abundant and Superficial Expression of C-Type Lectin Receptors in Ectocervix of Women at Risk of HIV Infection
Hirbod T; Kaldensjoe T; Lopalco L; Klareskog E; Andersson S; Uberti-Foppa C; Ferrari D; Manghi M; Andersson J; Lore K; Broliden K
Meeting abstract: RETROVIROLOGY. 2009;6:p83
Evaluation of peripheral and bone marrow B cell responses in rhesus macaques after immunization with soluble HIV-1 gp140 trimers
Sundling C; Soldemo M; Chakrabarti B; Forsell MN; Lore K; Wyatt RT; Douagi I
Meeting abstract: RETROVIROLOGY. 2009;6:o35
Impact of in vivo CD4 binding during HIV-1 Env trimer immunizations of rhesus macaques
Douagi I; Forsell MM; Sundling C; O'dell S; Seder R; Mascola JR; Lore K; Wyatt RT
Meeting abstract: BLOOD. 2005;106(11):187
Keratinocyte growth factor increases thymic output of naive T-cells after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques.
Seggewiss R; Lore K; Guenaga FJ; Pittaluga S; Matappallil JJ; Ambrozak D; Bailer RT; Koup RA; Donahue RE; Blazar BR; Hollander GA; Douek DC; Dunbar CE
Review: METHODS IN CELL BIOLOGY. 2004;75:623-642
Isolation and immunophenotyping of human and rhesus macaque dendritic cells.
Loré K
Review: APMIS. 2003;111(7-8):776-788
The role of dendritic cells in the pathogenesis of HIV-1 infection.
Lore K; Larsson M
Thesis / dissertation: 2001
Immunological properties of dendritic cells in HIV-1 infection
Loré, Karin
Corrigendum: JOURNAL OF IMMUNOLOGICAL METHODS. 1998;218(1-2):173-187
Immunocytochemical detection of cytokines and chemokines in Langerhans cells and in vitro derived dendritic cells (vol 214, pg 97, 1998)
Loré K; Sönnerborg A; Spetz AL; Andersson U; Andersson J
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Professor, Medicin, Solna, Karolinska Institutet, 2014-

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Docent, Experimentell immunologi, Karolinska Institutet, 2010
MEDICINE DOKTORSEXAMEN, Institutionen för laboratoriemedicin, Karolinska Institutet, 2001
LICENTIATEXAMEN, Institutionen för laboratoriemedicin, Karolinska Institutet, 1999

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