Sten Linnarsson

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: NATURE NEUROSCIENCE. 2024;27(12):2267-2268
Ernest Arenas (1962-2024)
Ernfors P; Castelo-Branco G; Uhlen P; Linnarsson S; Marklund U; Hjerling-Leffler J; Dagliyan O
Article: NATURE COMMUNICATIONS. 2024;15(1):9381
High-parametric protein maps reveal the spatial organization in early-developing human lung
Sariyar S; Sountoulidis A; Hansen JN; Salas SM; Mardamshina M; Casals AM; Navarro FB; Andrusivova Z; Li X; Czarnewski P; Lundeberg J; Linnarsson S; Nilsson M; Sundstrom E; Samakovlis C; Lundberg E; Ayoglu B
Article: CANCER CELL. 2024;42(9):1528-1548.e17
Article GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
Liu I; Cruzeiro GAV; Bjerke L; Rogers RF; Grabovska Y; Beck A; Mackay A; Barron T; Hack OA; Quezada MA; Molinari V; Shaw ML; Perez-Somarriba M; Temelso S; Raynaud F; Ruddle R; Panditharatna E; Englinger B; Mire HM; Jiang L; Nascimento A; Labelle J; Haase R; Rozowsky J; Neyazi S; Baumgartner A-C; Castellani S; Hoffman SE; Cameron A; Morrow M; Nguyen Q-D; Pericoli G; Madlener S; Mayr L; Dorfer C; Geyeregger R; Rota C; Ricken G; Ligon KL; Alexandrescu S; Cartaxo RT; Lau B; Koschmann C; Braun E; Danan-Gotthold RM; Hu L; Siletti K; Sundstrom E; Hodge R; Lein E; Agnihotri S; Eisenstat DD; Stapleton S; King A; Bleil C; Mastronuzzi A; Cole KA; Waanders AJ; Carcaboso AM; Schuller U; Hargrave D; Vinci M; Carceller F; Haberler C; Slavc I; Linnarsson S; Gojo J; Monje M; Jones C; Filbin MG
Article: NATURE IMMUNOLOGY. 2024;25(6):1007-1019
Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells
Carrelha J; Mazzi S; Winroth A; Hagemann-Jensen M; Ziegenhain C; Hogstrand K; Seki M; Brennan MS; Lehander M; Wu B; Meng Y; Markljung E; Norfo R; Ishida H; Stralin KB; Grasso F; Karali CS; Aliouat A; Hillen A; Chari E; Siletti K; Thongjuea S; Mead AJ; Linnarsson S; Nerlov C; Sandberg R; Yoshizato T; Woll PS; Jacobsen SEW
Article: NEURON. 2023;111(22):3590-3603.e5
Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration
Munguba H; Nikouei K; Hochgerner H; Oberst P; Kouznetsova A; Ryge J; Munoz-Manchado AB; Close J; Batista-Brito R; Linnarsson S; Hjerling-Leffler J
Article: SCIENCE. 2023;382(6667):eadf6812
Transcriptomic cytoarchitecture reveals principles of human neocortex organization
Jorstad NL; Close J; Johansen N; Yanny AM; Barkan ER; Travaglini KJ; Bertagnolli D; Campos J; Casper T; Crichton K; Dee N; Ding S-L; Gelfand E; Goldy J; Hirschstein D; Kiick K; Kroll M; Kunst M; Lathia K; Long B; Martin N; Mcmillen D; Pham T; Rimorin C; Ruiz A; Shapovalova N; Shehata S; Siletti K; Somasundaram S; Sulc J; Tieu M; Torkelson A; Tung H; Callaway EM; Hof PR; Keene CD; Levi BP; Linnarsson S; Mitra PP; Smith K; Hodge RD; Bakken TE; Lein ES
Article: SCIENCE. 2023;382(6667):eade9516
Comparative transcriptomics reveals human-specific cortical features
Jorstad NL; Song JHT; Exposito-Alonso D; Suresh H; Castro-Pacheco N; Krienen FM; Yanny AM; Close J; Gelfand E; Long B; Seeman SC; Travaglini KJ; Basu S; Beaudin M; Bertagnolli D; Crow M; Ding S-L; Eggermont J; Glandon A; Goldy J; Kiick K; Kroes T; Mcmillen D; Pham T; Rimorin C; Siletti K; Somasundaram S; Tieu M; Torkelson A; Feng G; Hopkins WD; Hollt T; Keene CD; Linnarsson S; Mccarroll SA; Lelieveldt BP; Sherwood CC; Smith K; Walsh CA; Dobin A; Gillis J; Lein ES; Hodge RD; Bakken TE
Article: SCIENCE. 2023;382(6667):eadf5357
Single-cell DNA methylation and 3D genome architecture in the human brain
Tian W; Zhou J; Bartlett A; Zeng Q; Liu H; Castanon RG; Kenworthy M; Altshul J; Valadon C; Aldridge A; Nery JR; Chen H; Xu J; Johnson ND; Lucero J; Osteen JK; Emerson N; Rink J; Lee J; Li YE; Siletti K; Liem M; Claffey N; O'Connor C; Yanny AM; Nyhus J; Dee N; Casper T; Shapovalova N; Hirschstein D; Ding S-L; Hodge R; Levi BP; Keene CD; Linnarsson S; Lein E; Ren B; Behrens MM; Ecker JR
Journal article: IBRO REPORTS. 2023;15:s40
WHOLE BRAIN SINGLE NUCLEUS TRANSCRIPTOMICS IN HUMAN: WHAT WE KNOW SO FAR
Siletti K; Hodge R; Albiach AM; Lee KW; Ding S-L; Hu L; Lönnerberg P; Bakken T; Casper T; Clark M; Dee N; Gloe J; Keene CD; Nyhus J; Tung H; Yanny AM; Arenas E; Lein E; Linnarsson S
Article: NATURE NEUROSCIENCE. 2023;26(5):891-901
Profiling spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin
Li X; Andrusivova Z; Czarnewski P; Langseth CM; Andersson A; Liu Y; Gyllborg D; Braun E; Larsson L; Hu L; Alekseenko Z; Lee H; Avenel C; Kallner HK; Akesson E; Adameyko I; Nilsson M; Linnarsson S; Lundeberg J; Sundstrom E
Journal article: BIOINFORMATICS. 2023;39(4):btad126
RNAget: an API to securely retrieve RNA quantifications.
Upchurch S; Palumbo E; Adams J; Bujold D; Bourque G; Nedzel J; Graham K; Kagda MS; Assis P; Hitz B; Righi E; Guigó R; Wold BJ; GA4GH RNA-Seq Task Team
Article: NATURE CELL BIOLOGY. 2023;25(2):351-365
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
Sountoulidis A; Marco Salas S; Braun E; Avenel C; Bergenstrahle J; Theelke J; Vicari M; Czarnewski P; Liontos A; Abalo X; Andrusivova Z; Mirzazadeh R; Asp M; Li X; Hu L; Sariyar S; Martinez Casals A; Ayoglu B; Firsova A; Michaelsson J; Lundberg E; Waehlby C; Sundstroem E; Linnarsson S; Lundeberg J; Nilsson M; Samakovlis C
Article: STEM CELL REPORTS. 2023;18(1):337-353
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation
Nishimura K; Yang S; Lee KW; Asgrimsdottir ES; Nikouei K; Paslawski W; Gnodde S; Lyu G; Hu L; Salto C; Svenningsson P; Hjerling-Leffler J; Linnarsson S; Arenas E
Article: JOURNAL OF MOLECULAR BIOLOGY. 2022;434(15):167606
Dynamical Systems Model of RNA Velocity Improves Inference of Single-cell Trajectory, Pseudo-time and Gene Regulation
Liu R; Pisco AO; Braun E; Linnarsson S; Zou J
Article: DEVELOPMENTAL CELL. 2022;57(11):1421-1436.e5
Developmental landscape of human forebrain at a single-cell level identifies early waves of oligodendrogenesis
van Bruggen D; Pohl F; Langseth CM; Kukanja P; Lee H; Albiach AM; Kabbe M; Meijer M; Linnarsson S; Hilscher MM; Nilsson M; Sundstrom E; Castelo-Branco G
Journal article: NEURO-ONCOLOGY. 2022;24(Supplement_1):i188
INSP-12. Molecular architecture of the human brain and brain cancer
Linnarsson S
Article: CELL GENOMICS. 2022;2(3):100106-100107
Single nucleus multi-omics identifies human cortical cell regulatory genome diversity
Luo C; Liu H; Xie F; Armand EJ; Siletti K; Bakken TE; Fang R; Doyle WI; Stuart T; Hodge RD; Hu L; Wang B-A; Zhang Z; Preissl S; Lee D-S; Zhou J; Niu S-Y; Castanon R; Bartlett A; Rivkin A; Wang X; Lucero J; Nery JR; Davis DA; Mash DC; Satija R; Dixon JR; Linnarsson S; Lein E; Behrens MM; Ren B; Mukamel EA; Ecker JR
Article: NATURE. 2021;598(7879):86-102
A multimodal cell census and atlas of the mammalian primary motor cortex
Callaway EM; Dong H-W; Ecker JR; Hawrylycz MJ; Huang ZJ; Lein ES; Ngai J; Osten P; Ren B; Tolias AS; White O; Zeng H; Zhuang X; Ascoli GA; Behrens MM; Chun J; Feng G; Gee JC; Ghosh SS; Halchenko YO; Hertzano R; Lim BK; Martone ME; Ng L; Pachter L; Ropelewski AJ; Tickle TL; Yang XW; Zhang K; Bakken TE; Berens P; Daigle TL; Harris JA; Jorstad NL; Kalmbach BE; Kobak D; Li YE; Liu H; Matho KS; Mukamel EA; Naeemi M; Scala F; Tan P; Ting JT; Xie F; Zhang M; Zhang Z; Zhou J; Zingg B; Bertagnolli D; Casper T; Crichton K; Dee N; Diep D; Ding S-L; Dong W; Dougherty EL; Fong O; Goldman M; Goldy J; Hodge RD; Hu L; Keene CD; Krienen FM; Kroll M; Lake BB; Lathia K; Linnarsson S; Liu CS; Macosko EZ; McCarroll SA; McMillen D; Nadaf NM; Thuc NN; Palmer CR; Thanh P; Plongthongkum N; Reed NM; Regev A; Rimorin C; Romanow WJ; Savoia S; Siletti K; Smith K; Sulc J; Tasic B; Tieu M; Torkelson A; Tung H; van Velthoven CTJ; Vanderburg CR; Yanny AM; Fang R; Hou X; Lucero JD; Osteen JK; Pinto-Duarte A; Poirion O; Preissl S; Wang X; Aldridge AI; Bartlett A; Boggeman L; O'Connor C; Castanon RG; Chen H; Fitzpatrick C; Luo C; Nery JR; Nunn M; Rivkin AC; Tian W; Dominguez B; Ito-Cole T; Jacobs M; Jin X; Lee C-T; Lee K-F; Miyazaki PA; Pang Y; Rashid M; Smith JB; Vu M; Williams E; Armand E; Biancalani T; Booeshaghi AS; Crow M; Dudoit S; Fischer S; Gillis J; Hu Q; Kharchenko PV; Niu S-Y; Ntranos V; Purdom E; Risso D; de Bezieux HR; Somasundaram S; Street K; Svensson V; Vaishnav ED; Van den Berge K; Welch JD; Yao Z; An X; Bateup HS; Bowman I; Chance RK; Foster NN; Galbavy W; Gong H; Gou L; Hatfield JT; Hintiryan H; Hirokawa KE; Kim G; Kramer DJ; Li A; Li X; Luo Q; Munoz-Castaneda R; Stafford DA; Feng Z; Jia X; Jiang S; Jiang T; Kuang X; Larsen R; Lesnar P; Li Y; Li Y; Liu L; Peng H; Qu L; Ren M; Ruan Z; Shen E; Song Y; Wakeman W; Wang P; Wang Y; Wang Y; Yin L; Yuan J; Zhao S; Zhao X; Narasimhan A; Palaniswamy R; Banerjee S; Ding L; Huilgol D; Huo B; Kuo H-C; Laturnus S; Li X; Mitra PP; Mizrachi J; Wang Q; Xie P; Xiong F; Yu Y; Eichhorn SW; Berg J; Bernabucci M; Bernaerts Y; Cadwell CR; Castro JR; Dalley R; Hartmanis L; Horwitz GD; Jiang X; Ko AL; Miranda E; Mulherkar S; Nicovich PR; Owen SF; Sandberg R; Sorensen SA; Tan ZH; Allen S; Hockemeyer D; Lee AY; Veldman MB; Adkins RS; Ament SA; Bravo HC; Carter R; Chatterjee A; Colantuoni C; Crabtree J; Creasy H; Felix V; Giglio M; Herb BR; Kancherla J; Mahurkar A; McCracken C; Nickel L; Olley D; Orvis J; Schor M; Hood G; Dichter B; Grauer M; Helba B; Bandrowski A; Barkas N; Carlin B; D'Orazi FD; Degatano K; Gillespie TH; Khajouei F; Konwar K; Thompson C; Kelly K; Mok S; Sunkin S
Article: NATURE. 2021;597(7875):196-205
A roadmap for the Human Developmental Cell Atlas
Haniffa M; Taylor D; Linnarsson S; Aronow BJ; Bader GD; Barker RA; Camara PG; Camp JG; Chedotal A; Copp A; Etchevers HC; Giacobini P; Gottgens B; Guo G; Hupalowska A; James KR; Kirby E; Kriegstein A; Lundeberg J; Marioni JC; Meyer KB; Niakan KK; Nilsson M; Olabi B; Pe'er D; Regev A; Rood J; Rozenblatt-Rosen O; Satija R; Teichmann SA; Treutlein B; Vento-Tormo R; Webb S
Article: NATURE MEDICINE. 2021;27(3):546-559
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Muus C; Luecken MD; Eraslan G; Sikkema L; Waghray A; Heimberg G; Kobayashi Y; Vaishnav ED; Subramanian A; Smillie C; Jagadeesh KA; Duong ET; Fiskin E; Triglia ET; Ansari M; Cai P; Lin B; Buchanan J; Chen S; Shu J; Haber AL; Chung H; Montoro DT; Adams T; Aliee H; Allon SJ; Andrusivova Z; Angelidis I; Ashenberg O; Bassler K; Becavin C; Benhar I; Bergenstrahle J; Bergenstrahle L; Bolt L; Braun E; Bui LT; Callori S; Chaffin M; Chichelnitskiy E; Chiou J; Conlon TM; Cuoco MS; Cuomo ASE; Deprez M; Duclos G; Fine D; Fischer DS; Ghazanfar S; Gillich A; Giotti B; Gould J; Guo M; Gutierrez AJ; Habermann AC; Harvey T; He P; Hou X; Hu L; Hu Y; Jaiswal A; Ji L; Jiang P; Kapellos TS; Kuo CS; Larsson L; Leney-Greene MA; Lim K; Litvinukova M; Ludwig LS; Lukassen S; Luo W; Maatz H; Madissoon E; Mamanova L; Manakongtreecheep K; Leroy S; Mayr CH; Mbano IM; McAdams AM; Nabhan AN; Nyquist SK; Penland L; Poirion OB; Poli S; Qi C; Queen R; Reichart D; Rosas I; Schupp JC; Shea CV; Shi X; Sinha R; Sit RV; Slowikowski K; Slyper M; Smith NP; Sountoulidis A; Strunz M; Sullivan TB; Sun D; Talavera-Lopez C; Tan P; Tantivit J; Travaglini KJ; Tucker NR; Vernon KA; Wadsworth MH; Waldman J; Wang X; Xu K; Yan W; Zhao W; Ziegler CGK
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:594243
Effects of In Vivo Gluten Challenge on PBMC Gene Expression Profiles in Diet Treated Celiac Disease
Yohannes DA; de Kauwe A; Kaukinen K; Kurppa K; Maki M; Anderson RP; Linnarsson S; Greco D; Saavalainen P
Article: NATURE. 2020;587(7834):377-386
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky N; Almouzni G; Gorski SA; Aerts S; Amit I; Bertero MG; Bock C; Bredenoord AL; Cavalli G; Chiocca S; Clevers H; De Strooper B; Eggert A; Ellenberg J; Fernandez XM; Figlerowicz M; Gasser SM; Hubner N; Kjems J; Knoblich JA; Krabbe G; Lichter P; Linnarsson S; Marine J-C; Marioni JC; Marti-Renom MA; Netea MG; Nickel D; Nollmann M; Novak HR; Parkinson H; Piccolo S; Pinheiro I; Pombo A; Popp C; Reik W; Roman-Roman S; Rosenstiel P; Schultze JL; Stegle O; Tanay A; Testa G; Thanos D; Theis FJ; Torres-Padilla M-E; Valencia A; Vallot C; van Oudenaarden A; Vidal M; Voet T
Article: CELL REPORTS. 2020;31(5):107601
Srebf1 Controls Midbrain Dopaminergic Neurogenesis
Toledo EM; Yang S; Gyllborg D; van Wijk KE; Sinha I; Varas-Godoy M; Grigsby CL; Lonnerberg P; Islam S; Steffensen KR; Linnarsson S; Arenas E
Article: NATURE COMMUNICATIONS. 2019;10(1):4137
A cell fitness selection model for neuronal survival during development
Wang Y; Wu H; Fontanet P; Codeluppi S; Akkuratova N; Petitpre C; Xue-Franzen Y; Niederreither K; Sharma A; Da Silva F; Comai G; Agirman G; Palumberi D; Linnarsson S; Adameyko I; Moqrich A; Schedl A; La Manno G; Hadjab S; Lallemend F
Article: MOLECULAR PSYCHIATRY. 2019;24(2):182-197
Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals
Coleman JRI; Bryois J; Gaspar HA; Jansen PR; Savage JE; Skene N; Plomin R; Munoz-Manchado AB; Linnarsson S; Crawford G; Hjerling-Leffler J; Sullivan PF; Posthuma D; Breen G
Article: NATURE COMMUNICATIONS. 2019;10(1):514
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Goodridge JP; Jacobs B; Saetersmoen ML; Clement D; Hammer Q; Clancy T; Skarpen E; Brech A; Landskron J; Grimm C; Pfefferle A; Meza-Zepeda L; Lorenz S; Wiiger MT; Louch WE; Ask EH; Liu LL; Oei VYS; Kjallquist U; Linnarsson S; Patel S; Tasken K; Stenmark H; Malmberg K-J
Article: NATURE COMMUNICATIONS. 2018;9(1):3647
High-throughput chromatin accessibility profiling at single-cell resolution
Mezger A; Klemm S; Mann I; Brower K; Mir A; Bostick M; Farmer A; Fordyce P; Linnarsson S; Greenleaf W
Article: CELL REPORTS. 2018;24(8):2179-2190.e7
Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq
Munoz-Manchado AB; Gonzales CB; Zeisel A; Munguba H; Bekkouche B; Skene NG; Lonnerberg P; Ryge J; Harris KD; Linnarsson S; Hjerling-Leffler J
Article: NATURE GENETICS. 2018;50(7):912-919
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Savage JE; Jansen PR; Stringer S; Watanabe K; Bryois J; de Leeuw CA; Nagel M; Awasthi S; Barr PB; Coleman JRI; Grasby KL; Hammerschlag AR; Kaminski JA; Karlsson R; Krapohl E; Lam M; Nygaard M; Reynolds CA; Trampush JW; Young H; Zabaneh D; Hagg S; Hansell NK; Karlsson IK; Linnarsson S; Montgomery GW; Munoz-Manchado AB; Quinlan EB; Schumann G; Skene NG; Webb BT; White T; Arking DE; Avramopoulos D; Bilder RM; Bitsios P; Burdick KE; Cannon TD; Chiba-Falek O; Christoforou A; Cirulli ET; Congdon E; Corvin A; Davies G; Deary IJ; DeRosse P; Dickinson D; Djurovic S; Donohoe G; Conley ED; Eriksson JG; Espeseth T; Freimer NA; Giakoumaki S; Giegling I; Gill M; Glahn DC; Hariri AR; Hatzimanolis A; Keller MC; Knowles E; Koltai D; Konte B; Lahti J; Le Hellard S; Lencz T; Liewald DC; London E; Lundervold AJ; Malhotra AK; Melle I; Morris D; Need AC; Ollier W; Palotie A; Payton A; Pendleton N; Poldrack RA; Raikkonen K; Reinvang I; Roussos P; Rujescu D; Sabb FW; Scult MA; Smeland OB; Smyrnis N; Starr JM; Steen VM; Stefanis NC; Straub RE; Sundet K; Tiemeier H; Voineskos AN; Weinberger DR; Widen E; Yu J; Abecasis G; Andreassen OA; Breen G; Christiansen L; Debrabant B; Dick DM; Heinz A; Hjerling-Leffler J; Ikram MA; Kendler KS; Martin NG; Medland SE; Pedersen NL; Plomin R; Polderman TJC; Ripke S; van der Sluis S; Sullivan PF; Vrieze SI; Wright MJ; Posthuma D
Article: NATURE GENETICS. 2018;50(7):920-927
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
Nagel M; Jansen PR; Stringer S; Watanabe K; de Leeuw CA; Bryois J; Savage JE; Hammerschlag AR; Skene NG; Munoz-Manchado AB; White T; Tiemeier H; Linnarsson S; Hjerling-Leffler J; Polderman TJC; Sullivan PF; van der Sluis S; Posthuma D
Article: PLOS BIOLOGY. 2018;16(6):e2006387
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics
Harris KD; Hochgerner H; Skene NG; Magno L; Katona L; Gonzales CB; Somogyi P; Kessaris N; Linnarsson S; Hjerling-Leffler J
Article: NATURE GENETICS. 2018;50(6):825-833
Genetic identification of brain cell types underlying schizophrenia
Skene NG; Bryois JD; Bakken TE; Breen GP; Crowley JJ; Gaspar HA; Giusti-Rodriguez PC; Hodge RD; Miller JA; Munoz-Manchado AB; O'Donovan MC; Owen MJ; Pardinas AF; Ryge JP; Walters JT; Linnarsson S; Lein ES; Sullivan PF; Hjerling-Leffler JC
Article: NATURE NEUROSCIENCE. 2018;21(6):869-880
Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types
Haring M; Zeisel A; Hochgerner H; Rinwa P; Jakobsson JET; Lonnerberg P; La Manno G; Sharma N; Borgius L; Kiehn O; Lagerstrom MC; Linnarsson S; Ernfors P
Article: BMC CANCER. 2018;18(1):174
Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)
Kjallquist U; Erlandsson R; Tobin NP; Alkodsi A; Ullah I; Stalhammar G; Karlsson E; Hatschek T; Hartman J; Linnarsson S; Bergh J
Article: NATURE NEUROSCIENCE. 2018;21(2):290-299
Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing
Hochgerner H; Zeisel A; Lobnnerberg P; Linnarsson S
Article: GENOME MEDICINE. 2017;9(1):114
Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders
Nguyen HT; Bryois J; Kim A; Dobbyn A; Huckins LM; Munoz-Manchado AB; Ruderfer DM; Genovese G; Fromer M; Xu X; Pinto D; Linnarsson S; Verhage M; Smit AB; Hjerling-Leffler J; Buxbaum JD; Hultman C; Sklar P; Purcell SM; Lage K; He X; Sullivan PF; Stahl EA
Article: PLOS ONE. 2017;12(12):e0188772
Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells
Bostrom J; Sramkova Z; Salasova A; Johard H; Mahdessian D; Fedr R; Marks C; Medalova J; Soucek K; Lundberg E; Linnarsson S; Bryja V; Sekyrova P; Altun M; Andang M
Article: CELL STEM CELL. 2017;21(6):791-805.e9
Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor- Mediated Cellular Reprogramming
Ruetz T; Pfisterer U; Di Stefano B; Ashmore J; Beniazza M; Tian TV; Kaemena DF; Tosti L; Tan W; Manning JR; Chantzoura E; Ottosson DR; Collombet S; Johnsson A; Cohen E; Yusa K; Linnarsson S; Graf T; Parmar M; Kaji K
Article: ELIFE. 2017;6:e27041
The Human Cell Atlas
Regev A; Teichmann SA; Lander ES; Amt I; Benoist C; Birney E; Bodenmiller B; Campbell P; Carninci P; Clatworthy M; Clevers H; Deplancke B; Dunham I; Eberwine J; Elis R; Enard W; Farmer A; Fugger L; Gottgens B; Hacohen N; Haniffa M; Hemberg M; Kim S; Klenerman P; Kriegstein A; Lein ED; Linnarsson S; Lundberg E; Lundeberg J; Majumder P; Marioni JC; Merad M; Mhlanga M; Nawijin M; Netea M; Nolan G; Pe'er D; Phillipakis A; Ponting CP; Quake S; Reik W; Rozenblatt-Rosen O; Sanes J; Satija R; Schumacher TN; Shalek A; Shapiro E; Sharma P; Shin JW; Stegle O; Stratton M; Stubbington MJT; Theis FJ; Uhlen M; Van Oudenaarden A; Wagner A; Watt F; Weissman J; Wold B; Xavier R; Yosef N
Article: SCIENTIFIC REPORTS. 2017;7(1):16327
STRT-seq-2i: dual-index 5′ single cell and nucleus RNA-seq on an addressable microwell array
Hochgerner H; Lonnerberg P; Hodge R; Mikes J; Heskol A; Hubschle H; Lin P; Picelli S; La Manno G; Ratz M; Dunne J; Husain S; Lein E; Srinivasan M; Zeisel A; Linnarsson S
Article: SCIENTIFIC REPORTS. 2017;7(1):6031
A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA
Lake BB; Codeluppi S; Yung YC; Gao D; Chun J; Kharchenko PV; Linnarsson S; Zhang K
Article: MOLECULAR SYSTEMS BIOLOGY. 2017;13(5):930
Alternative TSSs are co-regulated in single cells in the mouse brain
Karlsson K; Lonnerberg P; Linnarsson S
Article: NATURE BIOTECHNOLOGY. 2017;35(5):444-452
Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model
Cervo PRDV; Romanov RA; Spigolon G; Masini D; Martin-Montanez E; Toledo EM; La Manno G; Feyder M; Pifl C; Ng Y-H; Sanchez SP; Linnarsson S; Wernig M; Harkany T; Fisone G; Arenas E
Article: CANCER RESEARCH. 2017;77(7):1741-1752
Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses
Niklasson M; Maddalo G; Sramkova Z; Mutlu E; Wee S; Sekyrova P; Schmidt L; Fritz N; Dehnisch I; Kyriatzis G; Krafcikova M; Carson BB; Feenstra JM; Marinescu VD; Segerman A; Haraldsson M; Gustavsson A-L; Hammarstrom LGJ; Jensen AJ; Uhrbom L; Altelaar AFM; Linnarsson S; Uhlen P; Trantirek L; Vincent CT; Nelander S; Enger PO; Andang M
Article: BMC GENOMICS. 2017;18(1):126
Single-cell mRNA isoform diversity in the mouse brain
Karlsson K; Linnarsson S
Article: NATURE NEUROSCIENCE. 2017;20(2):176-188
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov RA; Zeisel A; Bakker J; Girach F; Hellysaz A; Tomer R; Alpar A; Mulder J; Clotman F; Keimpema E; Hsueh B; Crow AK; Martens H; Schwindling C; Calvigioni D; Bains JS; Mate Z; Szabo G; Yanagawa Y; Zhang M-D; Rendeiro A; Farlik M; Uhlen M; Wulff P; Bock C; Broberger C; Deisseroth K; Hokfelt T; Linnarsson S; Horvath TL; Harkany T
Article: CELL. 2016;167(2):566-580.e19
Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells
La Manno G; Gyllborg D; Codeluppi S; Nishimura K; Salto C; Zeisel A; Borm LE; Stott SRW; Toledo EM; Villaescusa JC; Lonnerberg P; Ryge J; Barker RA; Arenas E; Linnarsson S
Article: DEVELOPMENT. 2016;143(19):3459-3469
The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation
Jouhilahti E-M; Madissoon E; Vesterlund L; Tohonen V; Krjutskov K; Reyes AP; Petropoulos S; Mansson R; Linnarsson S; Burglin T; Lanner F; Hovatta O; Katayama S; Kere J
Article: NATURE NEUROSCIENCE. 2016;19(10):1331-1340
Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control
Furlan A; La Manno G; Lubke M; Haring M; Abdo H; Hochgerner H; Kupari J; Usoskin D; Airaksinen MS; Oliver G; Linnarsson S; Ernfors P
Article: CELL SYSTEMS. 2016;3(3):221-237.e9
Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
Joost S; Zeisel A; Jacob T; Sun X; La Manno G; Lonnerberg P; Linnarsson S; Kasper M
Article: EMBO JOURNAL. 2016;35(18):1963-1978
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease
Villaescusa JC; Li B; Toledo EM; Cervo PRDV; Yang S; Stott SRW; Kaiser K; Islam S; Gyllborg D; Laguna-Goya R; Landreh M; Lonnerberg P; Falk A; Bergman T; Barker RA; Linnarsson S; Selleri L; Arenas E
Article: SCIENTIFIC REPORTS. 2016;6:28995
Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos
Madissoon E; Jouhilahti E-M; Vesterlund L; Tohonen V; Krjutskov K; Petropoulous S; Einarsdottir E; Linnarssons S; Lanner F; Mansson R; Hovatta O; Burglin TR; Katayama S; Kere J
Article: NATURE IMMUNOLOGY. 2016;17(7):797-805
Origin, fate and dynamics of macrophages at central nervous system interfaces
Goldmann T; Wieghofer P; Jordao MJC; Prutek F; Hagemeyer N; Frenzel K; Amann L; Staszewski O; Kierdorf K; Krueger M; Locatelli G; Hochgerner H; Zeiser R; Epelman S; Geissmann F; Priller J; Rossi FMV; Bechmann I; Kerschensteiner M; Linnarsson S; Jung S; Prinz M
Article: SCIENCE. 2016;353(6294):78-82
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Stahl PL; Salmen F; Vickovic S; Lundmark A; Navarro JF; Magnusson J; Giacomello S; Asp M; Westholm JO; Huss M; Mollbrink A; Linnarsson S; Codeluppi S; Borg A; Ponten F; Costea PI; Sahlen P; Mulder J; Bergmann O; Lundeberg J; Frisen J
Article: SCIENCE. 2016;352(6291):1326-1329
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques S; Zeisel A; Codeluppi S; van Bruggen D; Falcao AM; Xiao L; Li H; Haring M; Hochgerner H; Romanov RA; Gyllborg D; Munoz-Manchado AB; La Manno G; Lonnerberg P; Floriddia EM; Rezayee F; Ernfors P; Arenas E; Hjerling-Leffler J; Harkany T; Richardson WD; Linnarsson S; Castelo-Branco G
Article: CELL. 2016;165(4):1012-1026
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
Article: SCIENTIFIC REPORTS. 2016;6:22745
NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis
Tervaniemi MH; Katayama S; Skoog T; Siitonen HA; Vuola J; Nuutila K; Sormunen R; Johnsson A; Linnarsson S; Suomela S; Kankuri E; Kere J; Elomaa O
Article: NATURE BIOTECHNOLOGY. 2016;34(2):175-183
Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes
Fuzik J; Zeisel A; Mate Z; Calvigioni D; Yanagawa Y; Szabo G; Linnarsson S; Harkany T
Article: STEM CELL REPORTS. 2015;5(5):843-855
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis
Fullgrabe A; Joost S; Are A; Jacob T; Sivan U; Haegebarth A; Linnarsson S; Simons BD; Clevers H; Toftgard R; Kasper M
Article: NATURE COMMUNICATIONS. 2015;6:8207
Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development
Tohonen V; Katayama S; Vesterlund L; Jouhilahti E-M; Sheikhi M; Madissoon E; Filippini-Cattaneo G; Jaconi M; Johnsson A; Burglin TR; Linnarsson S; Hovatta O; Kere J
Article: STEM CELL REPORTS. 2015;5(3):350-364
Reprogramming Roadblocks Are System Dependent
Chantzoura E; Skylaki S; Menendez S; Kim S-I; Johnsson A; Linnarsson S; Woltjen K; Chambers I; Kaji K
Article: BMC GENOMICS. 2015;16(1):476
Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control
Katayama S; Skoog T; Jouhilahti E-M; Siitonen HA; Nuutila K; Tervaniemi MH; Vuola J; Johnsson A; Lonnerberg P; Linnarsson S; Elomaa O; Kankuri E; Kere J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(13):8348-8359
Rewired Metabolism in Drug-resistant Leukemia Cells A METABOLIC SWITCH HALLMARKED BY REDUCED DEPENDENCE ON EXOGENOUS GLUTAMINE
Staeubert C; Bhuiyan H; Lindahl A; Broom OJ; Zhu Y; Islam S; Linnarsson S; Lehtio J; Nordstrom A
Article: SCIENCE. 2015;347(6226):1138-1142
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel A; Munoz-Manchado AB; Codeluppi S; Lonnerberg P; La Manno G; Jureus A; Marques S; Munguba H; He L; Betsholtz C; Rolny C; Castelo-Branco G; Hjerling-Leffler J; Linnarsson S
Article: GENOMICS. 2015;105(3):150-158
Amplification-free sequencing of cell-free DNA for prenatal non-invasive diagnosis of chromosomal aberrations
Karlsson K; Sahlin E; Iwarsson E; Westgren M; Nordenskjold M; Linnarsson S
Article: EMBO JOURNAL. 2015;34(1):36-54
A secretagogin locus of the mammalian hypothalamus controls stress hormone release
Romanov RA; Alpar A; Zhang M-D; Zeisel A; Calas A; Landry M; Fuszard M; Shirran SL; Schnell R; Dobolyi A; Olah M; Spence L; Mulder J; Martens H; Palkovits M; Uhlen M; Sitte HH; Botting CH; Wagner L; Linnarsson S; Hokfelt T; Harkany T
Article: NATURE NEUROSCIENCE. 2015;18(1):145-153
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin D; Furlan A; Islam S; Abdo H; Lonnerberg P; Lou D; Hjerling-Leffler J; Haeggstrom J; Kharchenko O; Kharchenko PV; Linnarsson S; Ernfors P
Article: PLOS ONE. 2014;9(12):e115698
Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells
Wee S; Niklasson M; Marinescu VD; Segerman A; Schmidt L; Hermansson A; Dirks P; Forsberg-Nilsson K; Westermark B; Uhrbom L; Linnarsson S; Nelander S; Andang M
Article: CANCER CELL. 2014;25(6):794-808
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
Woll PS; Kjallquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstrom-Lindberg E; Linnarsson S; Jacobsen SEW
Article: NATURE METHODS. 2014;11(2):163-166
Quantitative single-cell RNA-seq with unique molecular identifiers
Islam S; Zeisel A; Joost S; La Manno G; Zajac P; Kasper M; Lonnerberg P; Linnarsson S
Journal article: GENOME BIOLOGY. 2014;15(10):486
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially-resolved RNA-seq
Zechel S; Zajac P; Lönnerberg P; Ibáñez CF; Linnarsson S
Article: GENOME BIOLOGY. 2014;15(10):486
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq
Zechel S; Zajac P; Lonnerberg P; Ibanez CF; Linnarsson S
Article: PLOS ONE. 2013;8(12):e85270
Base Preferences in Non-Templated Nucleotide Incorporation by MMLV-Derived Reverse Transcriptases
Zajac P; Islam S; Hochgerner H; Lonnerberg P; Linnarsson S
Journal article: BLOOD. 2013;122(21):4195
Diverse Genetic Lesions In Myelodysplastic Syndromes Originate Exclusively In Rare MDS Stem Cells
Woll P; Kjällquist U; Chowdhury O; Erlandsson R; Doolittle H; Ngara M; Anderson K; Giannoulatou E; Taylor S; Deng Q; Mead AJ; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Josefsen D; Kvalheim G; Göhring G; Schlegelberger B; Tobiasson M; Holm MS; Hokland P; Fenaux P; Nerlov C; Dybedal I; Nilsson L; Sandberg R; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW
Article: BIOINFORMATICS. 2013;29(22):2943-2945
SAMstrt: statistical test for differential expression in single-cell transcriptome with spike-in normalization
Katayama S; Tohonen V; Linnarsson S; Kere J
Article: PLOS ONE. 2013;8(8):e72409
Erg Channel Is Critical in Controlling Cell Volume during Cell Cycle in Embryonic Stem Cells
Abdelhady S; Kitambi SS; Lundin V; Aufschnaiter R; Sekyrova P; Sinha I; Lundgren KT; Castelo-Branco G; Linnarsson S; Wedlich-Soeldner R; Teixeira A; Andang M
Article: NATURE. 2013;499(7456):88-91
High-resolution analysis with novel cell-surface markers identifies routes to iPS cells
O'Malley J; Skylaki S; Iwabuchi KA; Chantzoura E; Ruetz T; Johnsson A; Tomlinson SR; Linnarsson S; Kaji K
Article: EMBO JOURNAL. 2012;31(18):3718-3729
Positional differences of axon growth rates between sensory neurons encoded by runx3
Lallemend F; Sterzenbach U; Hadjab-Lallemend S; Aquino JB; Castelo-Branco G; Sinha I; Villaescusa JC; Levanon D; Wang Y; Franck MCM; Kharchenko O; Adameyko I; Linnarsson S; Groner Y; Turner E; Ernfors P
Article: PLOS ONE. 2012;7(6):e38833
RNA-Seq Analysis Reveals Different Dynamics of Differentiation of Human Dermis- and Adipose-Derived Stromal Stem Cells
Jaeaeger K; Islam S; Zajac P; Linnarsson S; Neuman T
Article: NATURE PROTOCOLS. 2012;7(5):813-828
Highly multiplexed and strand-specific single-cell RNA 5′ end sequencing
Islam S; Kjallquist U; Moliner A; Zajac P; Fan J-B; Lonnerberg P; Linnarsson S
Journal article: PLOS ONE. 2012;7(2):10.1371/annotation/3f0ddf
Correction: Highly Parallel Genome-Wide Expression Analysis of Single Mammalian Cells
Fan J-B; Chen J; April CS; Fisher JS; Klotzle B; Bibikova M; Kaper F; Ronaghi M; Linnarsson S; Ota T; Chien J; Laurent LC; Loring JF; Nisperos SV; Chen GY; Zhong JF
Article: PLOS ONE. 2012;7(2):e30794
Highly Parallel Genome-Wide Expression Analysis of Single Mammalian Cells
Fan J-B; Chen J; April CS; Fisher JS; Klotzle B; Bibikova M; Kaper F; Ronaghi M; Linnarsson S; Ota T; Chien J; Laurent LC; Nisperos SV; Chen GY; Zhong JF
Article: NATURE METHODS. 2011;9(1):72-74
Counting absolute numbers of molecules using unique molecular identifiers
Kivioja T; Vaharautio A; Karlsson K; Bonke M; Enge M; Linnarsson S; Taipale J
Article: GENOME RESEARCH. 2011;21(7):1160-1167
Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq
Islam S; Kjallquist U; Moliner A; Zajac P; Fan J-B; Lonnerberg P; Linnarsson S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(37):16336-16341
En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons
Usoskin D; Zilberter M; Linnarsson S; Hjerling-Leffler J; Uhlen P; Harkany T; Ernfors P
Journal article: CANCER RESEARCH. 2010;70:1149
Genetic analysis of single cells
Fan J-B; Chen J; April C; Klotzle B; Royce T; Cann G; Talasaz AH; Islam S; Kjallquist U; Linnarsson S
Journal article: EUROPEAN JOURNAL OF PAIN. 2009;13(S1):s99a-ss99
324 DEVELOPMENT OF A NOVEL IN VITRO SYSTEM FOR THE STUDY OF MECHANORECEPTIVE COMPONENT IN NEUROPATHIC PAIN
Usoskin DG; Linnarsson S; Uhlen P; Ernfors P
Article: NATURE BIOTECHNOLOGY. 2008;26(6):676-684
Rapid genome sequencing with short universal tiling probes
Pihlak A; Bauren G; Hersoug E; Lonnerberg P; Metsis A; Linnarsson S
Article: NUCLEIC ACIDS RESEARCH. 2004;32(16):e127
Whole-genome expression profiling through fragment display and combinatorial gene identification -: art. no. e127
Metsis A; Andersson U; Baurén G; Ernfors P; Lönnerberg P; Montelius A; Oldin M; Pihlak A; Linnarsson S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(25):14681-14686
Activation by GDNF of a transcriptional program repressing neurite growth in dorsal root ganglia
Linnarsson S; Mikaels Å; Baudet C; Ernfors P
Article: BRAIN RESEARCH. 2000;75(1):61-69
Cell death in regenerating populations of neurons in BDNF mutant mice
Linnarsson S; Willson CA; Ernfors P
Article: NEURON. 1998;21(2):305-315
BDNF regulates Reelin expression and Cajal-Retzius cell development in the cerebral cortex
Ringstedt T; Linnarsson S; Wagner J; Lendahl U; Kokaia Z; Arenas E; Ernfors P; Ibáñez CF
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(12):2581-2587
Learning deficit in BDNF mutant mice
Linnarsson S; Björklund A; Ernfors P
Article: DEVELOPMENT. 1996;122(2):491-500
Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets
Elshamy WM; Linnarsson S; Lee KF; Jaenisch R; Ernfors P
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 1995;363(2):307-320
DEPENDENCE OF DEVELOPING GROUP IA AFFERENTS ON NEUROTROPHIN-3
KUCERA J; FAN GP; JAENISCH R; LINNARSSON S; ERNFORS P
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Professor, Medicinsk biokemi och biofysik, Karolinska Institutet, 2015-

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FILOSOFIE DOKTOR, Institutionen för medicinsk biokemi och biofysik, Karolinska Institutet, 2001

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