Sten Linnarsson

Sten Linnarsson

Professor
E-postadress: sten.linnarsson@ki.se
Besöksadress: Solnavägen 9, 6C, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Linnarsson, 171 77 Stockholm
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Utvalda publikationer

  • Article: NATURE. 2024;:1-8
    Mannens CCA; Hu L; Lonnerberg P; Schipper M; Reagor CC; Li X; He X; Barker RA; Sundstrom E; Posthuma D; Linnarsson S
  • Article: SCIENCE. 2023;382(6667):eadd7046
    Siletti K; Hodge R; Albiach AM; Lee KW; Ding S-L; Hu L; Lonnerberg P; Bakken T; Casper T; Clark M; Dee N; Gloe J; Hirschstein D; Shapovalova NV; Keene CD; Nyhus J; Tung H; Yanny AM; Arenas E; Lein ES; Linnarsson S
  • Article: SCIENCE. 2023;382(6667):eadf7044
    Li YE; Preissl S; Miller M; Johnson ND; Wang Z; Jiao H; Zhu C; Wang Z; Xie Y; Poirion O; Kern C; Pinto-Duarte A; Tian W; Siletti K; Emerson N; Osteen J; Lucero J; Lin L; Yang Q; Zhu Q; Zemke N; Espinoza S; Yanny AM; Nyhus J; Dee N; Casper T; Shapovalova N; Hirschstein D; Hodge RD; Linnarsson S; Bakken T; Levi B; Keene CD; Shang J; Lein E; Wang A; Behrens MM; Ecker JR; Ren B
  • Article: SCIENCE. 2023;382(6667):eadf1226
    Braun E; Danan-Gotthold M; Borm LE; Lee KW; Vinsland E; Lonnerberg P; Hu L; Li X; He X; Andrusivova Z; Lundeberg J; Barker RA; Arenas E; Sundstrom E; Linnarsson S
  • Preprint: BIORXIV. 2023
    Mossi Albiach A; Janusauskas J; Jacobsen JK; Kapustová I; Karamzadeh R; Kvedaraite E; Hu L; Franck M; Mannens C; Codeluppi S; Munting J; Borm L; Shamikh A; Lönnerberg P; Siletti K; Persson O; Linnarsson S
  • Article: NATURE BIOTECHNOLOGY. 2023;41(2):222-231
    Borm LE; Albiach AM; Mannens CCA; Janusauskas J; Ozgun C; Fernandez-Garcia D; Hodge R; Castillo F; Hedin CRH; Villablanca EJ; Uhlen P; Lein ES; Codeluppi S; Linnarsson S
  • Article: NATURE. 2021;598(7879):111-119
    Bakken TE; Jorstad NL; Hu Q; Lake BB; Tian W; Kalmbach BE; Crow M; Hodge RD; Krienen FM; Sorensen SA; Eggermont J; Yao Z; Aevermann BD; Aldridge AI; Bartlett A; Bertagnolli D; Casper T; Castanon RG; Crichton K; Daigle TL; Dalley R; Dee N; Dembrow N; Diep D; Ding S-L; Dong W; Fang R; Fischer S; Goldman M; Goldy J; Graybuck LT; Herb BR; Hou X; Kancherla J; Kroll M; Lathia K; van Lew B; Li YE; Liu CS; Liu H; Lucero JD; Mahurkar A; McMillen D; Miller JA; Moussa M; Nery JR; Nicovich PR; Niu S-Y; Orvis J; Osteen JK; Owen S; Palmer CR; Pham T; Plongthongkum N; Poirion O; Reed NM; Rimorin C; Rivkin A; Romanow WJ; Sedeno-Cortes AE; Siletti K; Somasundaram S; Sulc J; Tieu M; Torkelson A; Tung H; Wang X; Xie F; Yanny AM; Zhang R; Ament SA; Behrens MM; Bravo HC; Chun J; Dobin A; Gillis J; Hertzano R; Hof PR; Hollt T; Horwitz GD; Keene CD; Kharchenko PV; Ko AL; Lelieveldt BP; Luo C; Mukamel EA; Pinto-Duarte A; Preissl S; Regev A; Ren B; Scheuermann RH; Smith K; Spain WJ; White OR; Koch C; Hawrylycz M; Tasic B; Macosko EZ; McCarroll SA; Ting JT; Zeng H; Zhang K; Feng G; Ecker JR; Linnarsson S; Lein ES
  • Article: NATURE. 2021;596(7870):92-96
    La Manno G; Siletti K; Furlan A; Gyllborg D; Vinsland E; Mossi Albiach A; Mattsson Langseth C; Khven I; Lederer AR; Dratva LM; Johnsson A; Nilsson M; Lonnerberg P; Linnarsson S
  • Article: NATURE METHODS. 2018;15(11):932-935
    Codeluppi S; Borm LE; Zeisel A; La Manno G; van Lunteren JA; Svensson CI; Linnarsson S
  • Article: NATURE. 2018;560(7719):494-498
    La Manno G; Soldatov R; Zeisel A; Braun E; Hochgerner H; Petukhov V; Lidschreiber K; Kastriti ME; Lonnerberg P; Furlan A; Fan J; Borm LE; Liu Z; van Bruggen D; Guo J; He X; Barker R; Sundstrom E; Castelo-Branco G; Cramer P; Adameyko I; Linnarsson S; Kharchenko PV
  • Article: CELL. 2018;174(4):999-1014.e22
    Zeisel A; Hochgerner H; Lonnerberg P; Johnsson A; Memic F; van der Zwan J; Haring M; Braun E; Borm LE; La Manno G; Codeluppi S; Furlan A; Lee K; Skene N; Harris KD; Hjerling-Leffler J; Arenas E; Ernfors P; Marklund U; Linnarsson S

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2023 - 31 December 2026
    Recent advances in single-cell biology have enabled very large-scale mapping of cell types and cell states. Emerging brain cell atlases now provide unprecedented access to the molecular composition of normal cell types, including gene expression and regulatory chromatin modifications. In parallel, efforts to map human brain tumors are underway in many labs, leading to an emerging conceptual framework where tumors are viewed as analogous to developmental processes. However, previous work in glioblastoma has largely neglected inter- and intra-tumor heterogeneity, the spatial dimension of tumor heterogeneity, and the dynamic aspect of interconversion between cellular states. Here, we propose to focus intensely on these aspects, and ask a number of related questions about tumor growth. For example, which subpopulations drive tumor growth? What is the rate of cell division in different subpopulations? Are there quiescent stem cells that can cause relapse? What is the lineage relationship between tumor subpopulations, and how do they relate to normal brain development? Can phenotypic subpopulations interconvert freely or do they form a hierarchy, or are they isolated independent clones? What is the relationship between tumor cell phenotype and local environment, e.g. proxmity to vessels or white matter? What is the phenotype of distant, disseminating tumor cells, versus those of the tumor mass? What is the variability between tumors from different patients?
  • VINNOVA
    1 September 2019 - 31 December 2020
  • Single-cell analysis
    Swedish Foundation for Strategic Research
    1 January 2016 - 31 December 2020
  • Functional neuromics of the cerebral cortex.
    Wellcome Trust Ltd
    1 October 2015 - 31 March 2022
  • Knut and Alice Wallenberg Foundation
    1 January 2015 - 1 January 2020
  • Molecular classification of cortical neurons by combining lineage tracing and transcriptomics
    International Human Frontier Science Program Organization
    1 May 2014 - 30 April 2017
  • Swedish Research Council
    1 January 2014 - 31 December 2017
  • European Research Council
    1 November 2010 - 31 October 2015
  • Multiple single-cell and multiple gene expression analysis
    Swedish Foundation for Strategic Research
    1 August 2009 - 31 August 2012

Anställningar

  • Professor, Medicinsk biokemi och biofysik, Karolinska Institutet, 2015-

Examina och utbildning

  • FILOSOFIE DOKTOR, Institutionen för medicinsk biokemi och biofysik, Karolinska Institutet, 2001

Uppdrag

  • Dekan, KI Solna, Karolinska Institutet, 2024-
  • Prefekt, Medicinsk biokemi och biofysik, Karolinska Institutet, 2021-2023

Priser och utmärkelser

  • Methusalem Lecture, VIB Leuven, 2023
  • Nicholson Lecture, Rockefeller University, 2017
  • Erik K. Fernström Prize, 2015

Nyheter från KI

Kalenderhändelser från KI