Sophie Erhardt
Professor | Prefekt | Docent
E-postadress: sophie.erhardt@ki.se
Telefon: +46852486883
Mobiltelefon: +46706296706
Besöksadress: Solnavägen 9, Biomedicum C5, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa Neuropsykoimmunologi, 171 77 Stockholm
Om mig
- Professor i Experimentell Psykiatri samt forskargruppsledare för
Neuropsykoimmunologi [1]på institutionen för fysiologi och farmakologi.
[1] http://ki.se/fyfa/neuropsykoimmunologi
Artiklar
- Journal article: NATURE COMMUNICATIONS. 2026;17(1):7604Goteson A; Nilsson J; Camporesi E; Klahn AL; Horbeck E; Sigstrom R; Jonsson L; Sparding T; Palsson E; Pelanis A; Goulding A; Isgren A; Erhardt S; Cervenka S; Bulik CM; Zetterberg H; Blennow K; Sellgren CM; Brinkmalm A; Landen M
- Article: NEUROBIOLOGY OF STRESS. 2026;42:100820Ostman L; Paul ER; Zhang H; Larsson E; Perini I; Schwieler L; Erhardt S; Holm L; Axen A; Mayo LM; Heilig M; Capusan AJ
- Article: TRANSLATIONAL PSYCHIATRY. 2026;16(1):337Maki-Marttunen V; Nerland S; Jorgensen KN; Hogestol EA; Rokicki J; Alnaes D; Borgwardt S; Boye B; Buitelaar J; Boen E; Cervenka S; Conzelmann A; Erhardt S; Franke B; Celius EG; Harbo HF; Hilland E; Hoekstra P; Hartman CA; Jonassen R; Jonsson EG; Landro NI; Lesch K-P; Maglanoc LA; Pauli P; Sellgren CM; Nygaard GO; Oosterlaan J; Schmidt A; Schwarz E; Ziegler GC; Agartz I; Westlye LT; Andreassen OA; Kaufmann T; Elvsashagen T
- Article: SCHIZOPHRENIA. 2026;12(1):43Cullen AE; Lee M; Josefsson P; Sellgren CM; Erhardt S; Mittendorfer-Rutz E; Cervenka S
- Article: BRAIN, BEHAVIOR, & IMMUNITY - HEALTH. 2026;53:101221Lindahl J; Veiback GS; Suneson K; Blanking W; Tjernberg J; Stahl D; Wiman A; Ventorp F; Erhardt S; Lindqvista D
- Article: TRANSLATIONAL PSYCHIATRY. 2026;16(1):236Arjmand S; Chaudhary M; Samudyata; Piehl F; Pelanis A; Engberg G; Cervenka S; Landen M; Erhardt S; Sellgren CM
- Journal article: ACTA NEUROPSYCHIATRICA. 2025;38:e7Wegener G; Erhardt S; Andreassen OA; Chiliza B; Atwoli L; Dickens A
- Article: ACTA PHYSIOLOGICA. 2025;241(12):e70123Louvrou V; Eimantas N; Juskeviciute E; Solianik R; Brazaitis M; Engberg G; Erhardt S
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2025;28(10):pyaf072Santi MM; Genovese E; Schou TM; da Silva M; Erhardt S; Schwieler L; Weidenfors JA; Marino G; Paludan SR; Joca S; Wegener G; Reinert L; Bay-Richter C
- Article: SCHIZOPHRENIA. 2025;11(1):88Malmqvist A; Eren F; Schwieler L; Orhan F; Fatouros-Bergman H; Flyckt L; Piehl F; Cervenka S; Baeck M; Sellgren CM; Engberg G; Erhardt S
- Journal article: BIOLOGICAL PSYCHIATRY. 2025;97(9):s133Ercis M; Beaupre LMM; Fridh P; Weidenfors JA; Khan R; Coombes BJ; Cuellar-Barboza AB; Prieto ML; McElroy SL; Ozerdem A; Biernacka JM; Erhardt S; Frye MA
- Article: AMERICAN JOURNAL OF PSYCHIATRY. 2025;182(4):389-400Orhan F; Malwade S; Khanlarkhani N; Gkogka A; Langeder A; Jungholm O; Koskuvi M; Lehtonen S; Schwieler L; Jardemark K; Tiihonen J; Koistinaho J; Erhardt S; Engberg G; Samudyata S; Sellgren CM
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2025;125:452-465Weidenfors JA; Griska V; Li X; Pranckeviciene A; Pakalniene J; Atlas A; Franzen-Rohl E; Piehl F; Lindquist L; Mickiene A; Engberg G; Schwieler L; Erhardt S
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2025;124:163-176Li X; Eden A; Malwade S; Cunningham JL; Bergquist J; Weidenfors JA; Sellgren CM; Engberg G; Piehl F; Gisslen M; Kumlien E; Virhammar J; Orhan F; Rostami E; Schwieler L; Erhardt S
- Article: PLOS ONE. 2025;20(1):e0317201Wallin H; Jansson E; Erhardt S; Wallquist C; Hylander B; Jacobson SH; Caidahl K; Rickenlund A; Eriksson MJ
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10):2007-2015Kamandulis S; Lukonaitiene I; Snieckus A; Brazaitis M; Mickevicius M; Cernych M; Ruas J; Schwieler L; Louvrou V; Erhardt S; Westerblad H; Venckunas T
- Article: EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2024;78(8):677-683Louvrou V; Solianik R; Brazaitis M; Erhardt S
- Article: JAMA PSYCHIATRY. 2024;81(5):468-476Lee M; Cernvall M; Borg J; Plaven-Sigray P; Larsson C; Erhardt S; Sellgren CM; Fatouros-Bergman H; Cervenka S
- Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2024;171:306-315Haroon H; Ho AM-C; Gupta VK; Dasari S; Sellgren CM; Cervenka S; Engberg G; Eren F; Erhardt S; Sung J; Choi D-S
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;117:313-319Koskuvi M; Malwade S; Lekander JG; Horbeck E; Bruno S; Larsson JH; Pelanis A; Isgren A; Goulding A; Fatouros-Bergman H; Samudyata; Schalling M; Piehl F; Erhardt S; Landen M; Cervenka S; Orhan F; Sellgren CM
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Alla övriga publikationer
- Preprint: RESEARCH SQUARE. 2026Blujdea E-R; Hok-A-Hin Y; Schumacher A-M; Maple-Grødem J; Cano A; Ali M; Price R; Göteson A; Abdelhak A; Sogorb-Esteve A; Sim MA; Dammer E; Kamalian A; Reus L; Trares K; Simonsen A; Pudas S; Mesleh A; Rizzo M; Jiang Y; Binette AP; Kuiperij H; Jabbari E; Åkesson J; Snoek B; Jern C; Tjernberg I; Burman J; Fujita K; Sundström-Poromaa I; Haglund S; Bränn E; Boström G; Braun M; Mortensen JE; Bellomo G; Fraser D; Abraira L; Lambert A; Menéndez-Valladares P; Bentivenga G; Tachino J; Tsang R; Fraser J; Paslawski W; Rosenström A; Ran C; Kivisäkk P; Ghelfi L; Rutledge J; Zheng K; Frank J; Malwade S; Sellgren C; Albert M; Alcolea D; Al-Shaban F; Andersson B; Barough SS; Blennow K; Boada M; Boxer A; Brockmann K; Brown R; Bulik C; Capdevila M; Belin A; Cervenka S; Chen-Plotkin A; Chevalier C; Chokoshvili D; Cinque P; Domínguez-Mayoral A; Dravid A; Düzel E; Elofsson U; Engelborghs S; Erskine E; Fernández-Vega A; Fladby T; Foltynie T; Frisoni G; Gaetani L; Gasser T; Gisslen M; Fernandes SG; Halvorsen B; Hansson O; Hermann A; Ho S; Höglinger G; Hojjati S; Hristovska I; Hvass C; Ip N; Irwin D; Janelidze S; Jessen F; Khandaker G; Kikukawa Y; Kodali MC; Kollmorgen G; Krishnan R; Krüger R; Kultima K; Lange J; Lemstra A; Levit M; Liao YK; Lleó A; Lutz M; Mammana A; Mattsson-Carlgren N; Mellergård J; Millischer V; Mongan D; Montaner J; Morris H; Muñoz-Morales Á; Okuzono Y; Otto M; Pavlovic I; Ton APV; Petzold G; Piehl F; Pijnenburg Y; Puerta R; Ratajczak-Tretel B; Richards M; Kristensen S; Rojas J; Schneider A; Shahid-Besanti M; Skogman B; Skogseth R; Spottke A; Svensson C; Tijms B; Tysnes O-B; Visser P-J; von Arnim C; Vos S; Zhang B; Consortium TE; Nilsson I; Cannon M; Arnold S; Steinberg A; Saloner R; Timsina J; Kosek E; Rohrer J; Matsumoto H; Markus H; Aamodt AH; Prassas I; Pedersen S; Virhammar J; Ingelsson M; Skalkidou A; Cunningham J; Izumi Y; Svenningsson A; Henningsson A; Adolfsson AN; Adolfsson R; Aarsland D; Alves G; Das S; Núñez-Jurado D; Pennypacker K; Timpson NJ; Gustafsson M; Erhardt S; de Berg WV; Verbeek M; Fu A; Parchi P; Abdo W; MacAulay N; Hasselbalch S; Johnson E; Chen C; Parnetti L; El-Agnaf O; Landén M; Svenningsson P; Stanne T; Lee SVD; Tarawneh R; Poston K; Zetterberg H; Ruiz A; Moghekar A; Cruchaga C; Campo MD; Vermunt L; Teunissen C
- Review: SCHIZOPHRENIA RESEARCH: COGNITION. 2025;42:100387Lee M; Cullen AE; Matheson GJ; Lu Z-A; Bergen SE; Sellgren CM; Erhardt S; Fatouros-Bergman H; Cervenka S
- Preprint: RESEARCH SQUARE. 2025Göteson A; Nilsson J; Camporesi E; Klahn L; Hörbeck E; Sigström R; Jonsson L; Sparding T; Pålsson E; Pelanis A; Goulding A; Isgren A; Erhardt S; Cervenka S; Bulik C; Zetterberg H; Blennow K; Sellgren C; Brinkmalm A; Landén M
- Preprint: MEDRXIV. 2025Runneberger I; Garton D; Choopanian P; Montaño-Rodríguez A; Mirzaie M; Orhan F; Yakimov V; Moussiopoulou J; Iivanainen V; Olfat S; CDP-Working group; Schmitt A; Falkai P; Keskitalo S; Varjosalo M; Cervenka S; Sellgren C; Erhardt S; Fagerström-Billai F; Damdimopoulos A; Engberg G; Wagner E; Raabe F; Andressoo J-O
- Conference publication: BIOLOGICAL PSYCHIATRY. 2025;97(9)Ercis M; Beaupre LMM; Fridh P; Weidenfors JA; Khan R; Coombes BJ; Cuellar-Barboza AB; Prieto ML; McElroy SL; Ozerdem A; Biernacka JM; Erhardt S; Frye MA
- Preprint: BIORXIV. 2025Mäki-Marttunen V; Nerland S; Jørgensen KN; Høgestøl EA; Rokicki J; Alnæs D; Borgwardt S; Boye B; Buitelaar J; Bøen E; Cervenka S; Conzelmann A; Erhardt S; Franke B; Celius E G; Harbo HF; Hilland E; Hoekstra P; Hartman CA; Jonassen R; Jönsson E G; Landrø NI; Lesch K-P; Maglanoc LA; Pauli P; Sellgren CM; Nygaard GO; Oosterlaan J; Schmidt A; Schwarz E; Ziegler GC; Agartz I; Westlye LT; Andreassen OA; Kaufmann T; Elvsåshagen T
- Preprint: MEDRXIV. 2024Lee M; Cullen A; Matheson G; Lu Z-A; Bergen S; Sellgren C; Erhardt S; Fatouros-Bergman H; Cervenka S
- Conference publication: NEUROPSYCHOPHARMACOLOGY. 2024;49:400-401Erhardt S; Schrey D; Ebberyd A; Eriksson LI; Gomez M
- Review: PHARMACOLOGICAL REVIEWS. 2024;76(6):978-1008Pocivavsek A; Schwarcz R; Erhardt S
- Editorial: NEUROPSYCHOPHARMACOLOGY. 2024;49(1):307-308Pocivavsek A; Erhardt S
- Conference publication: NEUROPSYCHOPHARMACOLOGY. 2023;48:356-357Erhardt S; Gravenfors Y; Schwieler L
- Letter: BRAIN BEHAVIOR AND IMMUNITY. 2023;114:163-164Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
- Preprint: BIORXIV. 2023Orhan F; Malwade S; Khanlarkhani N; Gkoga A; Jungholm O; Koskuvi M; Lehtonen Š; Schwieler L; Jardemark K; Tiihonen J; Koistinaho J; Erhardt S; Engberg G; Samudyata S; Sellgren C
- Conference publication: BIOLOGICAL PSYCHIATRY. 2023;93(9):S24Tye S; Price J; Walker A; Sutor S; Erhardt S; Schwieler L; Cullen K; Voort JV; Frye M; Bobo W; Shiroma P
- Conference publication: BIOLOGICAL PSYCHIATRY. 2023;93(9):S24Voort JV; Singh B; Riva-Posse P; Erhardt S; Schwieler L; Pazdernik V; Frye M; Tye S
- Preprint: MEDRXIV. 2023Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Troßbach S; Willbold D; Erhardt S; Bannach O; Korth C
- Review: BRAIN SCIENCES. 2023;13(3):505Chahla MAN; Khalil MI; Comai S; Brundin L; Erhardt S; Guillemin GJ
- Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:290-291Schwieler L; Weidenfors JA; Griska V; Li X; Piehl F; Mickiene A; Erhardt S
- Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:378-379Erhardt S; Schwieler L; Sellgren CM; Eren F; Cervenka S; Piehl F; Bergman HF; Orhan F; Engberg G
- Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:277Tye S; Price JB; Walker A; Kruse J; Cullen K; Frye M; Schwieler L; Erhardt S
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Forskningsbidrag
- Swedish Research Council1 januari 2025 - 31 december 2027The kynurenine pathway, generating neuroactive metabolites, plays a crucial role in mental processes. Excess of kynurenic acid (KYNA), driven by immune activation, triggers psychosis and cognitive dysfunction. This project aims to reduce brain KYNA by developing kynurenine aminotransferase (KAT) III inhibitors. Traditionally, KAT II dominates KYNA productionhowever, our research reveals that immune activation induces KAT III. Together with SciLifeLab DDD, we have developed potent, brain-penetrant, and patentable KAT III-selective molecules. Our research encompasses five work packages where we will a) perform in vivo proof-of-concept studies of our developed KAT III inhibitors and assess KAT II and KAT III inhibition´s comparative efficacy in curbing KYNA production in immune-induced states. b) Investigate KAT III inhibition´s impact on dopamine neurotransmission and cognition. c) Develop antisense oligonucleotids (ASOs) for KAT III. d) Utilize brain-specific cellular models to investigate the efficacy of ASOs to prevent KYNA production, and to elucidate KAT II and KAT III localization and their specific roles in KYNA production. e) Develop biomarkers for patient selection for KAT III inhibitor treatment and to verify treatment response. This project may revolutionize psychiatric care with tailored treatments for immune-induced cognitive impairment or psychosis. Through interdisciplinary collaboration, we aim to advance psychiatry into modern precision medicine´s forefront.
- Swedish Research Council1 januari 2022 - 31 december 2024
- Swedish Research Council1 januari 2022 - 31 december 2024
- Generation of enzyme inhibitors for the treatment of immune-induced psychosis and cognitive deficitsNovo Nordisk Foundation1 augusti 2021 - 31 juli 2022
- Swedish Research Council1 januari 2020 - 31 december 2023
- Swedish Research Council1 november 2019 - 30 november 2019
- Swedish Research Council1 januari 2018 - 31 december 2021
- Swedish Research Council1 januari 2018 - 31 december 2020
- Swedish Research Council1 januari 2017 - 31 december 2019
- Swedish Research Council1 januari 2014 - 31 december 2017
- Swedish Research Council1 januari 2012 - 31 december 2013
- Swedish Research Council1 januari 2012 - 31 december 2013
- Swedish Research Council1 september 2010 - 31 augusti 2016
- Swedish Research Council1 september 2010 - 31 augusti 2016
- Swedish Research Council1 januari 2010 - 31 december 2011
Anställningar
- Professor, Experimentell psykiatri, Fysiologi och farmakologi, Karolinska Institutet, 2016-
Examina och utbildning
- Docent, Farmakologi, Karolinska Institutet, 2006
- MEDICINE DOKTORSEXAMEN, Institutionen för fysiologi och farmakologi, Karolinska Institutet, 2001
Uppdrag
- Prefekt, Fysiologi och farmakologi, Karolinska Institutet, 2022-