Sophie Erhardt

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Professor i Experimentell Psykiatri samt forskargruppsledare för
Neuropsykoimmunologi [1]på institutionen för fysiologi och farmakologi.
[1] http://ki.se/fyfa/neuropsykoimmunologi

Artiklar

Journal article: PHARMACOLOGICAL REVIEWS. 2024;76(6):978-1008
Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities.
Pocivavsek A; Schwarcz R; Erhardt S
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10):2007-2015
Mood, Cognitive Function, and Plasma Kynurenine Metabolites Responses Following Severe Changes in Physical Activity
Kamandulis S; Lukonaitiene I; Snieckus A; Brazaitis M; Mickevicius M; Cernych M; Ruas J; Schwieler L; Louvrou V; Erhardt S; Westerblad H; Venckunas T
Journal article: EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2024;78(8):677-683
Exploring the effect of prolonged fasting on kynurenine pathway metabolites and stress markers in healthy male individuals
Louvrou V; Solianik R; Brazaitis M; Erhardt S
Article: JAMA PSYCHIATRY. 2024;81(5):468-476
Cognitive Function and Variability in Antipsychotic Drug-Naive Patients With First-Episode Psychosis
Lee M; Cernvall M; Borg J; Plaven-Sigray P; Larsson C; Erhardt S; Sellgren CM; Fatouros-Bergman H; Cervenka S
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;117:313-319
Lower complement C1q levels in first-episode psychosis and in schizophrenia
Koskuvi M; Malwade S; Lekander JG; Horbeck E; Bruno S; Larsson JH; Pelanis A; Isgren A; Goulding A; Fatouros-Bergman H; Samudyata; Schalling M; Piehl F; Erhardt S; Landen M; Cervenka S; Orhan F; Sellgren CM
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2024;171:306-315
Cerebrospinal fluid proteomic signatures are associated with symptom severity of first-episode psychosis
Haroon H; Ho AM-C; Gupta VK; Dasari S; Sellgren CM; Cervenka S; Engberg G; Eren F; Erhardt S; Sung J; Choi D-S
Journal article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2024;17:11786469241262876
The Tryptophan Metabolite Indole-3-Propionic Acid Raises Kynurenic Acid Levels in the Rat Brain In Vivo
Sathyasaikumar KV; Blanco-Ayala T; Zheng Y; Schwieler L; Erhardt S; Tufvesson-Alm M; Poeggeler B; Schwarcz R
Article: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2023;77(12):665-671
Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis
Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Trossbach S; Willbold D; Erhardt S; Bannach O; Korth C
Article: ACTA NEUROPSYCHIATRICA. 2023;:1-13
Dual administration of lipopolysaccharide induces behavioural changes in rats relevant to psychotic disorders
Zheng Y-R; Tufvesson-Alm M; Trepci A; Imbeault S; Li X-Q; Schwieler L; Engberg G; Erhardt S
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2023;111:376-385
Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity
Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Article: SCHIZOPHRENIA RESEARCH. 2023;257:34-40
CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance
Orhan F; Goiny M; Becklen M; Mathe L; Piehl F; Schwieler L; Fatouros-Bergman H; Farde L; Cervenka S; Sellgren CM; Engberg G; Erhardt S
Article: PSYCHONEUROENDOCRINOLOGY. 2023;153:106110
Lipopolysaccharide-induced changes in the kynurenine pathway and symptoms of sickness behavior in humans
Balter LJT; Li X; Schwieler L; Erhardt S; Axelsson J; Olsson MJ; Lasselin J; Lekander M
Article: LEUKEMIA. 2023;37(4):888-900
Cognitive impairments correlate with increased central nervous system immune activation after allogeneic haematopoietic stem cell transplantation
Boberg E; Kadri N; Hagey DWW; Schwieler L; El Andaloussi S; Erhardt S; Iacobaeus E; Le Blanc K
Journal article: NEUROSCIENCE APPLIED. 2023;2:103551
Kynurenic acid promotes activity-dependent synaptic pruning and associates with genetic risk variance for schizophrenia
Orhan F; Malwade S; Schwieler L; Tiihonen J; Koistinahu J; Erhardt S; Engberg G; Kent J; Samudyata S; Sellgren C
Article: NATURE COMMUNICATIONS. 2022;13(1):6427
Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia
Gracias J; Orhan F; Horbeck E; Holmen-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Demirel IS; Fu T; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yanez VAC; Gopfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
Article: INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS. 2022;10(1):26
A physically active lifestyle is associated with lower long-term incidence of bipolar disorder in a population-based, large-scale study
Svensson M; Erhardt S; Hallmarker U; James S; Deierborg T
Article: HELIYON. 2022;8(9):e10424
Facial affect recognition in first-episode psychosis is impaired but not associated with psychotic symptoms
Larsson C; Lee M; Lundgren T; Erhardt S; Sellgren CM; Cervenka S; Borg J; Bolte S; Fatouros-Bergman H
Article: MOLECULAR PSYCHIATRY. 2022;27(8):3247-3261
Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
Matlik K; Garton DR; Montano-Rodriguez AR; Olfat S; Eren F; Casserly L; Damdimopoulos A; Panhelainen A; Porokuokka LL; Kopra JJ; Turconi G; Schweizer N; Bereczki E; Piehl F; Engberg G; Cervenka S; Piepponen TP; Zhang F-P; Sipila P; Jakobsson J; Sellgren CM; Erhardt S; Andressoo J-O
Article: BRITISH JOURNAL OF NUTRITION. 2022;129(6):1-8
Two-day fasting affects kynurenine pathway with additional modulation of short-term whole-body cooling: a quasi-randomised crossover trial
Solianik R; Schwieler L; Trepci A; Erhardt S; Brazaitis M
Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):229
Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients
Shang P; Ho AM-C; Tufvesson-Alm M; Lindberg DR; Grant CW; Orhan F; Eren F; Bhat M; Engberg G; Schwieler L; Fatouros-Bergman H; Imbeault S; Iverson RM; Dasari S; Piehl F; Cervenka S; Sellgren CM; Erhardt S; Choi D-S
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2022;101:136-145
Peripheral and central kynurenine pathway abnormalities in major depression
Paul ER; Schwieler L; Erhardt S; Boda S; Trepci A; Kampe R; Asratian A; Holm L; Yngve A; Dantzer R; Heilig M; Hamilton JP; Samuelsson M
Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240
Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
Plaven-Sigray P; Ikonen Victorsson P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Sellgren CM; Erhardt S; Agartz I; Halldin C; Farde L; Cervenka S
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):566
Screening for pathogenic neuronal autoantibodies in serum and CSF of patients with first-episode psychosis
Theorell J; Ramberger M; Harrison R; Mgbachi V; Jacobson L; Waters P; Erhardt S; Sellgren CM; Cervenka S; Piehl F; Irani SR
Article: MOLECULAR PSYCHIATRY. 2021;26(11):6820-6832
GRK3 deficiency elicits brain immune activation and psychosis
Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schullman A; Goiny M; Svensson CI; Hokfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landen M; Engberg G; Erhardt S
Journal article: BRAIN, BEHAVIOR, AND IMMUNITY. 2021;98:50
Inflammation moderates stress resilience and ketamine response in male antidepressant-resistant rats
Price JB; Walker AJ; Yates C; Erhardt S; Schwieler L; Tye SJ
Article: NPJ SCHIZOPHRENIA. 2021;7(1):46
No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
Lee M; Fatouros-Bergman H; Plaven-Sigray P; Victorsson PI; Sellgren CM; Erhardt S; Flyckt L; Farde L; Cervenka S
Article: ANTIOXIDANTS. 2021;10(9):1443
Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans
Wyckelsma VL; Trepci A; Schwieler L; Venckunas T; Brazaitis M; Kamandulis S; Paulauskas H; Gapeyeva H; Paasuke M; Gastaldello S; Imbeault S; Westerblad H; Erhardt S; Andersson DC
Article: SCIENTIFIC REPORTS. 2021;11(1):7527
Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis
Becklen M; Orhan F; Piehl F; Cervenka S; Sellgren CM; Flyckt L; Erhardt S; Fatouros-Bergman H
Journal article: ACTA NEUROPSYCHIATRICA. 2021;33(2):111-112
IN MEMORIAM Torgny H. Svensson May 15th 1945-June 12th 2020
Erhardt S; Eriksson E; Engberg G; Wegener G
Article: SCHIZOPHRENIA RESEARCH. 2021;228:118-123
Disrupted sensorimotor gating in first-episode psychosis patients is not affected by short-term antipsychotic treatment
Hedberg M; Imbeault S; Erhardt S; Schwieler L
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;43:52-62
Central levels of tryptophan metabolites in subjects with bipolar disorder
Trepci A; Sellgren CM; Palsson E; Brundin L; Khanlarkhani N; Schwieler L; Landen M; Erhardt S
Article: SCIENTIFIC REPORTS. 2021;11(1):1669
Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects
Isung J; Granqvist M; Trepci A; Huang J; Schwieler L; Kierkegaard M; Erhardt S; Jokinen J; Piehl F
Article: FRONTIERS IN PSYCHIATRY. 2021;12:714014
Physical Activity Is Associated With Lower Long-Term Incidence of Anxiety in a Population-Based, Large-Scale Study
Svensson M; Brundin L; Erhardt S; Hallmarker U; James S; Deierborg T
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2021;14:11786469211041368
Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice
Imbeault S; Gubert Olive M; Jungholm O; Erhardt S; Wigstrom H; Engberg G; Jardemark K
Article: JOURNAL OF NEUROIMMUNOLOGY. 2020;349:577401
Repeated administration of LPS exaggerates amphetamine-induced locomotor response and causes learning deficits in mice
Tufvesson-Alm M; Imbeault S; Liu X-C; Zheng Y; Faka A; Choi D-S; Schwieler L; Engberg G; Erhardt S
Article: BIOLOGICAL PSYCHIATRY: COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 2020;5(12):1095-1103
Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder: A Multisample Diffusion Tensor Imaging Study
Tonnesen S; Kaufmann T; de Lange A-MG; Richard G; Nhat TD; Alnaes D; van der Meer D; Rokicki J; Moberget T; Maximov II; Agartz I; Aminoff SR; Beck D; Barch DM; Beresniewicz J; Cervenka S; Fatouros-Bergman H; Craven AR; Flyckt L; Gurholt TP; Haukvik UK; Hugdahl K; Johnsen E; Jonsson EG; Kolskar KK; Kroken RA; Lagerberg TV; Loberg E-M; Nordvik JE; Sanders A-M; Ulrichsen K; Andreassen OA; Westlye LT
Article: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2020;270(7):933-938
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
Johansson V; Erhardt S; Engberg G; Kegel M; Bhat M; Schwieler L; Blennow K; Zetterberg H; Cannon TD; Wetterberg L; Hultman CM; Landen M
Article: NATURE COMMUNICATIONS. 2020;11(1):4016
The genetic architecture of human brainstem structures and their involvement in common brain disorders
Elvsashagen T; Bahrami S; van der Meer D; Agartz I; Alnaes D; Barch DM; Baur-Streubel R; Bertolino A; Beyer MK; Blasi G; Borgwardt S; Boye B; Buitelaar J; Boen E; Celius EG; Cervenka S; Conzelmann A; Coynel D; Di Carlo P; Djurovic S; Eisenacher S; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Gelao B; Harbo HF; Hartman CA; Haberg A; Heslenfeld D; Hoekstra PJ; Hogestol EA; Jonassen R; Jonsson EG; Kirsch P; Kloszewska I; Lagerberg TV; Landro NI; Le Hellard S; Lesch K-P; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Nordvik JE; Nyberg L; O'Connell KS; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; de Quervain D; Reif A; Rokicki J; van Rooij D; Shadrin AA; Schmidt A; Schwarz E; Selbaek G; Soininen H; Sowa P; Steen VM; Tsolaki M; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Kaufmann T; Farde L; Flyckt L; Engberg G; Erhardt SS; Fatouros-Bergman H; Cervenka S; Schwieler L; Piehl F; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F; Sellgren CM
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(12):1756-1761
Synthesis and Preclinical Evaluation of 6-[¹⁸F]Fluorine-α- methyl-L-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake
Krasikova R; Kondrashov M; Avagliano C; Petukhov M; Vazquez-Romero A; Revunov E; Johnstrom P; Tari L; Toth M; Haggkvist J; Erhardt S; Cervenka S; Schou M
Article: IBRO REPORTS. 2020;8:136-142
CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects
Xu C; Sellgren CM; Fatouros-Bergman H; Piehl F; Blennow K; Zetterberg H; Brinkmalm A; Santillo AF; Lundgren S; Cervenka S; Engberg G; Erhardt S
Article: BIOANALYSIS. 2020;12(6):379-392
A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid
Schwieler L; Trepci A; Krzyzanowski S; Hermansson S; Granqvist M; Piehl F; Venckunas T; Brazaitis M; Kamandulis S; Lindqvist D; Jones AD; Erhardt S; Brundin L
Article: ACTA NEUROPSYCHIATRICA. 2020;32(1):43-53
Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation
Imbeault S; Goiny M; Liu X; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2020;13:1178646920978241
Quantification of Plasma Kynurenine Metabolites Following One Bout of Sprint Interval Exercise
Trepci A; Imbeault S; Wyckelsma VL; Westerblad H; Hermansson S; Andersson DC; Piehl F; Venckunas T; Brazaitis M; Kamandulis S; Brundin L; Erhardt S; Schwieler L
Article: PSYCHIATRY RESEARCH. 2019;281:112546
Long distance ski racing is associated with lower long-term incidence of depression in a population based, large-scale study
Svensson M; Brundin L; Erhardt S; Madaj Z; Hallmarker U; James S; Deierborg T
Article: NATURE NEUROSCIENCE. 2019;22(10):1617-1623
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Kaufmann T; van der Meer D; Nhat TD; Schwarz E; Lund MJ; Agartz I; Alnaes D; Barch DM; Baur-Streubel R; Bertolino A; Bettella F; Beyer MK; Boen E; Borgwardt S; Brandt CL; Buitelaar J; Celius EG; Cervenka S; Conzelmann A; Cordova-Palomera A; Dale AM; de Quervain DJF; Carlo P; Djurovic S; Dorum ES; Eisenacher S; Elvsashagen T; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Haatveit B; Haberg AK; Harbo HF; Hartman CA; Heslenfeld D; Hoekstra PJ; Hogestol EA; Jernigan TL; Jonassen R; Jonsson EG; Kirsch P; Ktoszewska I; Kolskar KK; Landro NI; Hellard S; Lesch K-P; Lovestone S; Lundervold A; Lundervold AJ; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Norbom LB; Nordvik JE; Nyberg L; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; Richard G; Rokicki J; Sanders A-M; Selbaek G; Shadrin AA; Smeland OB; Soininen H; Sowa P; Steen VM; Tsolaki M; Ulrichsen KM; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Farde L; Flyckts L; Engberg G; Erhardt S; Fatouros-Bergmann H; Schwieler L; Piehl F; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: SCHIZOPHRENIA RESEARCH. 2019;210:221-227
Increased peripheral levels of TARC/CCL17 in first episode psychosis patients
Malmqvist A; Schwieler L; Orhan F; Fatouros-Bergman H; Bauer M; Flyckt L; Cervenka S; Engberg G; Piehl F; Erhardt S; Farde L; Flyckt L; Engberg G; Erhardt S; Fatouros-Bergman H; Cervenka S; Schwieler L; Piehl F; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: JAMA PSYCHIATRY. 2019;76(7):739-748
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
Alnaes D; Kaufmann T; van der Meer D; Cordova-Palomera A; Rokicki J; Moberget T; Bettella F; Agartz I; Barch DM; Bertolino A; Brandt CL; Cervenka S; Djurovic S; Nhat TD; Eisenacher S; Fatouros-Bergman H; Flyckt L; Di Giorgio A; Haatveit B; Jonsson EG; Kirsch P; Lund MJ; Meyer-Lindenberg A; Pergola G; Schwarz E; Smeland OB; Quarto T; Zink M; Andreassen OA; Westlye LT; Farde L; Collste K; Victorsson P; Engberg G; Erhardt S; Malmqvist A; Hedberg M; Orhan F; Sellgren CM; Schwieler L; Piehl F
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):37
Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls
Sellgren CM; Gracias J; Jungholm O; Perlis RH; Engberg G; Schwieler L; Landen M; Erhardt S
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):12
Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder
Schwarz E; Nhat TD; Pergola G; Westlye LT; Kaufmann T; Wolfers T; Brecheisen R; Quarto T; Ing AJ; Di Carlo P; Gurholt TP; Harms RL; Noirhomme Q; Moberget T; Agartz I; Andreassen OA; Bellani M; Bertolino A; Blasi G; Brambilla P; Buitelaar JK; Cervenka S; Flyckt L; Frangou S; Franke B; Hall J; Heslenfeld DJ; Kirsch P; McIntosh AM; Noethen MM; Papassotiropoulos A; de Quervain DJ-F; Rietschel M; Schumann G; Tost H; Witt SH; Zink M; Meyer-Lindenberg A; Bettella F; Brandt CL; Clarke T-K; Coynel D; Degenhardt F; Djurovic S; Eisenacher S; Fastenrath M; Fatouros-Bergman H; Forstner AJ; Frank J; Gambi F; Gelao B; Geschwind L; Di Giannantonio M; Di Giorgio A; Hartman CA; Heilmann-Heimbach S; Herms S; Hoekstra PJ; Hoffmann P; Hoogman M; Jonsson EG; Loos E; Maggioni E; Oosterlaan J; Papalino M; Rampino A; Romaniuk L; Selvaggi P; Sepede G; Sonderby IE; Spalek K; Sussmann JE; Thompson PM; Vasquez AA; Vogler C; Whalley H; Farde L; Flyckt L; Engberg G; Erhardt S; Fatouros-Bergman H; Cervenka S; Schwieler L; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2019;12:1178646919891169
Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice
Peyton L; Oliveros A; Tufvesson-Alm M; Schwieler L; Starski P; Engberg G; Erhardt S; Choi D-S
Article: BIOLOGICAL PSYCHIATRY. 2018;84(9):644-654
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Bustillo JR; Clark VP; Agartz I; Mueller BA; Cahn W; de Zwarte SMC; Pol HEH; Kahn RS; Ophoff RA; van Haren NEM; Andreassen OA; Dale AM; Nhat TD; Gurholt TP; Hartberg CB; Haukvik UK; Jorgensen KN; Lagerberg TV; Melle I; Westlye LT; Gruber O; Kraemer B; Richter A; Zilles D; Calhoun VD; Crespo-Facorro B; Roiz-Santianez R; Tordesillas-Gutierrez D; Loughland C; Carr VJ; Catts S; Cropley VL; Fullerton JM; Green MJ; Henskens FA; Jablensky A; Lenroot RK; Mowry BJ; Michie PT; Pantelis C; Quide Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Weickert CS; Weickert TW; Morris DW; Hong E; Kochunov P; Beard LM; Gur RE; Gur RC; Satterthwaite TD; Wolf DH; Belger A; Brown GG; Ford JM; Macciardi F; Mathalon DH; O'Leary DS; Potkin SG; Preda A; Voyvodic J; Lim KO; McEwen S; Yang F; Tan Y; Tan S; Wang Z; Fan F; Chen J; Xiang H; Tang S; Guo H; Wan P; Wei D; Bockholt HJ; Ehrlich S; Wolthusen RPF; King MD; Shoemaker JM; Sponheim SR; De Haan L; Koenders L; Machielsen MW; van Amelsvoort T; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; McKenna PJ; Pomarol-Clotet E; Salvador R; Corvin A; Donohoe G; Kelly S; Whelan CD; Dickie EW; Rotenberg D; Voineskos AN; Ciufolini S; Radua J; Dazzan P; Murray R; Marques TR; Simmons A; Borgwardt S; Egloff L; Harrisberger F; Riecher-Roessler A; Smieskova R; Alpert KI; Wang L; Jonsson EG; Koops S; Sommer IEC; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Stephen JM; Kwon JS; Yun J-Y; Cannon DM; McDonald C; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Busatto GF; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; Hagenaars SP; McIntosh AM; Whalley HC; Lawrie SM; Knoechel C; Oertel-Knoechel V; Staeblein M; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; McMahon A; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2018;138(5):432-440
Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis
Orhan F; Schwieler L; Fatouros-Bergman H; Malmqvist A; Cervenka S; Collste K; Flyckt L; Farde L; Sellgren CM; Piehl F; Engberg G; Erhardt S
Article: NEUROPHARMACOLOGY. 2018;138:130-139
Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: L Check for Relevance for schizophrenia
Tufvesson-Alm M; Schwieler L; Schwarcz R; Goiny M; Erhardt S; Engberg G
Article: MOLECULAR PSYCHIATRY. 2018;23(5):1244-1250
CSF GABA is reduced in first-episode psychosis and associates to symptom severity
Orhan F; Fatouros-Bergman H; Goiny M; Malmqvist A; Piehl F; Cervenka S; Collste K; Victorsson P; Sellgren CM; Flyckt L; Erhardt S; Engberg G
Article: PSYCHOLOGICAL MEDICINE. 2018;48(1):82-94
Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium
Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santianez R; Crespo-Facorro B; Suarez-Pinilla P; van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jorgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Morch-Johnsen L; Faerden A; Flyckt L; Fatouros-Bergman H; Jonsson EG; Hashimoto R; Yamamori H; Fukunaga M; Jahanshad N; De Rossi P; Piras F; Banaj N; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Kraemer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: JOURNAL OF NEUROIMMUNOLOGY. 2017;313:1-9
LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning
Oliveros A; Wininger K; Sens J; Larsson MK; Liu XC; Choi S; Faka A; Schwieler L; Engberg G; Erhardt S; Choi DS
Article: BIOLOGICAL PSYCHIATRY. 2017;82(10):756-765
Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders
Erhardt S; Pocivavsek A; Repici M; Liu X-C; Imbeault S; Maddison DC; Thomas MAR; Smalley JL; Larsson MK; Muchowski PJ; Giorgini F; Schwarcz R
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856
Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [¹¹C]PBR28
Collste K; Plaven-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2017;135(5):439-447
Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium
Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santianez R; Crespo-Facorro B; Suarez-Pinilla P; Van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jorgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Morch-Johnsen L; Faerden A; Flyckt L; Fatouros-Bergman H; Jonsson EG; Hashimoto R; Yamamori H; Fukunaga M; Preda A; De Rossi P; Piras F; Banaj N; Ciullo V; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Kraemer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: ACTA NEUROPSYCHIATRICA. 2017;29(1):54-58
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression
Liu X-C; Erhardt S; Goiny M; Engberg G; Mathe AA
Article: PSYCHIATRY RESEARCH. 2017;247:105-112
Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity
Kegel ME; Johansson V; Wetterberg L; Bhat M; Schwieler L; Cannon TD; Schuppe-Koistinen I; Engberg G; Landen M; Hultman CM; Erhardt S
Article: NEUROPSYCHIATRIC DISEASE AND TREATMENT. 2017;13:967-972
Twelve-week physical exercise does not have a long-lasting effect on kynurenines in plasma of depressed patients
Millischer V; Erhardt S; Ekblom O; Forsell Y; Lavebratt C
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;84(5):262-271
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes
Orhan F; Bhat M; Sandberg K; Stahl S; Piehl F; Svensson C; Erhardt S; Schwieler L
Article: MOLECULAR PSYCHIATRY. 2016;21(10):1342-1350
A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
Sellgren CM; Kegel ME; Bergen SE; Ekman CJ; Olsson S; Larsson M; Vawter MP; Backlund L; Sullivan PF; Sklar P; Smoller JW; Magnusson PKE; Hultman CM; Walther-Jallow L; Svensson CI; Lichtenstein P; Schalling M; Engberg G; Erhardt S; Landen M
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761
Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes
Mudry JM; Alm PS; Erhardt S; Goiny M; Fritz T; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Article: PSYCHONEUROENDOCRINOLOGY. 2016;71:189-196
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects
Coccaro EF; Lee R; Fanning JR; Fuchs D; Goiny M; Erhardt S; Christensen K; Brundin L; Coussons-Read M
Article: NEUROCHEMICAL RESEARCH. 2016;41(9):2243-2255
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice
Larsson MK; Faka A; Bhat M; Imbeault S; Goiny M; Orhan F; Oliveros A; Stahl S; Liu XC; Choi DS; Sandberg K; Engberg G; Schwieler L; Erhardt S
Article: TRANSLATIONAL PSYCHIATRY. 2016;6(8):e865
An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation
Brundin L; Sellgren CM; Lim CK; Grit J; Palsson E; Landen M; Samuelsson M; Lundgren K; Brundin P; Fuchs D; Postolache TT; Traskman-Bendz L; Guillemin GJ; Erhardt S
Article: FEBS LETTERS. 2016;590(14):2063-2075
EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway
Mutz CN; Schwentner R; Kauer MO; Katschnig AM; Kromp F; Aryee DNT; Erhardt S; Goiny M; Alonso J; Fuchs D; Kovar H
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2016;310(10):C836-C840
Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans
Schlittler M; Goiny M; Agudelo LZ; Venckunas T; Brazaitis M; Skurvydas A; Kamandulis S; Ruas JL; Erhardt S; Westerblad H; Andersson DC
Article: JOURNAL OF AFFECTIVE DISORDERS. 2016;193:349-354
The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability
Ventorp F; Barzilay R; Erhardt S; Samuelsson M; Traskman-Bendz L; Janelidze S; Weizman A; Offen D; Brundin L
Article: NEUROPHARMACOLOGY. 2016;102:42-47
Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons
Linderholm KR; Alm MT; Larsson MK; Olsson SK; Goiny M; Hajos M; Erhardt S; Engberg G
Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):51
Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients
Schwieler L; Samuelsson M; Frye MA; Bhat M; Schuppe-Koistinen I; Jungholm O; Johansson AG; Landen M; Sellgren CM; Erhardt S
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2016;51:47-55
Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms
Aeinehband S; Brenner P; Stahl S; Bhat M; Fidock MD; Khademi M; Olsson T; Engberg G; Jokinen J; Erhardt S; Piehl F
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2015;131(4):269-278
Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels
Janelidze S; Suchankova P; Ekman A; Erhardt S; Sellgren C; Samuelsson M; Westrin A; Minthon L; Hansson O; Traskman-Bendz L; Brundin L
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2015;40(2):126-133
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia - significance for activation of the kynurenine pathway
Schwieler L; Larsson MK; Skogh E; Kegel ME; Orhan F; Abdelmoaty S; Finn A; Bhat M; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schuppe-Koistinen I; Svensson CI; Erhardt S; Engberg G
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2015;8:49-52
Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid.
Larsson MK; Schwieler L; Goiny M; Erhardt S; Engberg G
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2015;43:110-117
A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality
Bay-Richter C; Linderholm KR; Lim CK; Samuelsson M; Traskman-Bendz L; Guillemin GJ; Erhardt S; Brundin L
Article: CELL. 2014;159(1):33-45
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: MOLECULAR PSYCHIATRY. 2014;19(3):334-341
The KMO allele encoding Arg⁴⁵² is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression
Lavebratt C; Olsson S; Backlund L; Frisen L; Sellgren C; Priebe L; Nikamo P; Traskman-Bendz L; Cichon S; Vawter MP; Osby U; Engberg G; Landen M; Erhardt S; Schalling M
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2014;36:80-89
Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment - Role of brain kynurenic acid
Liu X-C; Holtze M; Powell SB; Terrando N; Larsson MK; Persson A; Olsson SK; Orhan F; Kegel M; Asp L; Goiny M; Schwieler L; Engberg G; Karlsson H; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2014;7:1-7
Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies.
Wennström M; Nielsen HM; Orhan F; Londos E; Minthon L; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2014;7:15-22
Imbalanced kynurenine pathway in schizophrenia.
Kegel ME; Bhat M; Skogh E; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schwieler L; Engberg G; Schuppe-Koistinen I; Erhardt S
Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(6):853-862
Altered chemokine levels in the cerebrospinal fluid and plasma of suicide attempters
Janelidze S; Ventorp F; Erhardt S; Hansson O; Minthon L; Flax J; Samuelsson M; Traskman-Bendz L; Brundin L
Article: NEUROPSYCHOPHARMACOLOGY. 2013;38(5):743-752
Connecting Inflammation with Glutamate Agonism in Suicidality
Erhardt S; Lim CK; Linderholm KR; Janelidze S; Lindqvist D; Samuelsson M; Lundberg K; Postolache TT; Traskman-Bendz L; Guillemin GJ; Brundin L
Article: PSYCHIATRY RESEARCH. 2013;205(1-2):165-167
CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis
Carlborg A; Jokinen J; Jonsson EG; Erhardt S; Nordstrom P
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e42
Working memory performance in bipolar disorder
Sellgren C; Engberg G; Erhardt S; Lichtenstein P; Landèn M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e41-e42
The Kynurenine pathway and cognitive performance in Euthymic bipolar disorder
Sellgren C; Olsson S; Erhardt S; Engberg G; Lichtenstein P; Landèn M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e25
Genome-wide study of CSF kynurenic acid in bipolar disorder implicates a molecular pathway underlying psychosis
Sellgren C; Kegel M; Ekman C; Olsson S; Svensson C; Hultman C; Lichtenstein P; Purcell S; Sullivan P; Sklar P; Engberg G; Erhardt S; Landèn M
Journal article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2012;28(&NA;):e4
Can routinely collected data be used for research on bipolar disorder? data from the St. Göran bipolar project
Landén M; Rydén E; Johansson A; Wetterberg L; Jakobsson J; Pålsson E; Ekman CJ; Sellgren C; Olsson S; Erhardt S; Båve U
Article: BIPOLAR DISORDERS. 2012;14(7):719-726
Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder
Olsson SK; Sellgren C; Engberg G; Landen M; Erhardt S
Article: SCHIZOPHRENIA BULLETIN. 2012;38(3):426-432
Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
Linderholm KR; Skogh E; Olsson SK; Dahl M-L; Holtze M; Engberg G; Samuelsson M; Erhardt S
Journal article: NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH. 2012;18(2):62
Low chemokine levels in the cerebrospinal fluid of suicide attempters
Janelidze S; Ventorp F; Erhardt S; Hansson O; Minthon L; Samuelsson M; Traskman-Bendz L; Brundin L
Article: JOURNAL OF NEURAL TRANSMISSION. 2012;119(2):155-163
Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice
Olsson SK; Larsson MK; Erhardt S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2012;37(1):53-57
Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls
Holtze M; Saetre P; Engberg G; Schwieler L; Werge T; Andreassen OA; Hall H; Terenius L; Agartz I; Jonsson EG; Schalling M; Erhardt S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2011;124(1):52-61
CSF biomarkers in suicide attempters - a principal component analysis
Lindqvist D; Janelidze S; Erhardt S; Traskman-Bendz L; Engstrom G; Brundin L
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2011;36(2):114-118
Elevation of cerebrospinal fluid interleukin-1β in bipolar disorder
Soderlund J; Olsson SK; Samuelsson M; Walther-Jallow L; Johansson C; Erhardt S; Landen M; Engberg G
Article: JOURNAL OF NEUROINFLAMMATION. 2010;7:44
Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct
Soderlund J; Erhardt S; Kast RE
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2010;13(4):475-485
Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1^-/- mice
Asp L; Holtze M; Powell SB; Karlsson H; Erhardt S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2010;35(3):195-199
Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder
Olsson SK; Samuelsson M; Saetre P; Lindstrom L; Jonsson EG; Nordin C; Engberg G; Erhardt S; Landen M
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2010;3:1-12
Role of the NMDA-receptor in Prepulse Inhibition in the Rat.
Linderholm K; Powell S; Olsson E; Holtze M; Snodgrass R; Erhardt S
Article: BIOLOGICAL PSYCHIATRY. 2009;66(3):287-292
Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity
Lindqvist D; Janelidze S; Hagell P; Erhardt S; Samuelsson M; Minthon L; Hansson O; Bjorkqvist M; Traskman-Bendz L; Brundin L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(4):501-512
Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia
Olsson SK; Andersson AS; Linderholm KR; Holtze M; Nilsson-Todd LK; Schwieler L; Olsson E; Larsson K; Engberg G; Erhardt S
Article: ENDOCRINOLOGY. 2008;149(12):6356-6365
Prenatal Dexamethasone Impairs Behavior and the Activation of the BDNF Exon IV Promoter in the Paraventricular Nucleus in Adult Offspring
Hossain A; Hajman K; Charitidi K; Erhardt S; Zimmermann U; Knipper M; Canlon B
Article: LIFE SCIENCES. 2008;83(5-6):170-175
Clozapine interacts with the glycine site of the NMDA receptor: Electrophysiological studies of dopamine neurons in the rat ventral tegmental area
Schwieler L; Linderholm KR; Nilsson-Todd LK; Erhardt S; Engberg G
Journal article: SCHIZOPHRENIA RESEARCH. 2008;102(1-3):94
KYNURENIC ACID IN CEREBROSPINAL FLUID AND BRAIN TISSUE LOSSES IN PATIENTS WITH FIRST-ONSET SCHIZOPHRENIA
Schröder J; Thomann P; Heuser M; Essig M; Holtze M; Erhardt S; Engberg G; Karlsson H
Journal article: JOURNAL OF PROTEOMICS AND BIOINFORMATICS. 2008;01(02):090-097
Comparative Proteome Analysis of Thalamus and Cortex from Rats Subchronically Treated with Kynurenine and Probenecid
Paulson L; Nilsson- Todd LK; Linderholm KR; Brinkmalm A; Eriksson PS; Engberg G; Erhardt S
Article: NEUROPHARMACOLOGY. 2007;53(8):918-924
Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: A pharmacological analysis
Linderholm KR; Andersson A; Olsson S; Olsson E; Snodgrass R; Engberg G; Erhardt S
Article: PHYSIOLOGY AND BEHAVIOR. 2007;92(1-2):203-209
The kynurenic acid hypothesis of schizophrenia
Erhardt S; Schwieler L; Nilsson L; Linderholm K; Engberg G
Article: ACTA NEUROPSYCHIATRICA. 2007;19(1):45-52
Cerebrospinal fluid kynurenic acid in male patients with schizophrenia -: correlation with monoamine metabolites
Nilsson-Todd LK; Nordin C; Joensson EG; Skogh E; Erhardt S
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2007;41(1-2):144-151
Cerebrospinal fluid kynurenic acid in male and female controls -: Correlation with monoamine metabolites and influences of confounding factors
Nilsson LK; Nordin C; Jonsson EG; Engberg G; Linderholm KR; Erhardt S
Article: JOURNAL OF NEURAL TRANSMISSION. 2006;113(5):557-571
Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons
Nilsson LK; Linderholm KR; Erhardt S
Article: SYNAPSE. 2006;59(5):290-298
Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons - Possible involvement of endogenous kynurenic acid
Schwieler L; Erhardt S; Nilsson L; Linderholm K; Engberg G
Article: SCHIZOPHRENIA RESEARCH. 2005;80(2-3):315-322
Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia
Nilsson LK; Linderholm KR; Engberg G; Paulson L; Blennow K; Lindström LH; Nordin C; Karanti A; Persson P; Erhardt S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):329-339
Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms
Nilsson LK; Schwieler L; Engberg G; Linderholm KR; Erhardt S
Article: JOURNAL OF NEURAL TRANSMISSION. 2005;112(7):863-872
Prostaglandin-mediated control of rat brain kynurenic acid synthesis - opposite actions by COX-1 and COX-2 isoforms
Schwieler L; Erhardt S; Erhardt C; Engberg G
Article: BIOLOGICAL PSYCHIATRY. 2004;56(4):255-260
Endogenous kynurenic acid disrupts prepulse inhibition
Erhardt S; Schwieler L; Emanuelsson C; Geyer M
Article: SYNAPSE. 2004;52(2):114-122
Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex
Schwieler L; Engberg G; Erhardt S
Article: NEUROPSYCHOPHARMACOLOGY. 2003;28(10):1770-1777
Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid
Schwieler L; Erhardt S
Article: LIFE SCIENCES. 2003;72(24):2793-2801
The anaesthetic agent propofol interacts with GABA_B-receptors:: an electrophysiological study in rat
Schwieler L; Delbro DS; Engberg G; Erhardt S
Article: ACTA PHYSIOLOGICA. 2002;175(1):45-53
Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid
Erhardt S; Engberg G
Article: SYNAPSE. 2002;43(4):227-237
Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine
Erhardt S; Schwieler L; Engberg L
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2002;365(3):173-180
GABA_B receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo
Erhardt S; Mathé JM; Chergui K; Engberg G; Svensson TH
Article: NEUROSCIENCE LETTERS. 2001;313(1-2):96-98
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
Erhardt S; Blennow K; Nordin C; Skogh E; Lindström LH; Engberg G
Article: AMINO ACIDS. 2001;20(4):353-362
Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons
Erhardt S; Öberg H; Mathé JM; Engberg G
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2001;363(1):21-27
Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons
Erhardt S; Öberg H; Engberg G
Article: LIFE SCIENCES. 2000;67(15):1901-1911
Excitation of nigral dopamine neurons by the GABA_A receptor agonist muscimol is mediated via release of glutamate
Erhardt S; Engberg G
Article: SYNAPSE. 2000;37(2):104-108
Nicotine-induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid
Erhardt S; Hajos M; Lindberg A; Engberg G
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2000;362(1):41-45
Nicotine inhibits firing activity of dorsal raphe 5-HT neurones in vivo
Engberg G; Erhardt S; Sharp T; Hajós M
Article: JOURNAL OF NEURAL TRANSMISSION. 1999;106(5-6):383-394
Activation of nigral dopamine neurons by the selective GABA_B-receptor antagonist SCH 50911
Erhardt S; Nissbrandt H; Engberg G
Article: NEUROSCIENCE LETTERS. 1998;255(2):115-118
Oxytocin increases locus coeruleus alpha 2-adrenoreceptor responsiveness in rats
Petersson M; Uvnäs-Moberg K; Erhardt S; Engberg G
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 1998;357(6):611-619
Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by γ-hydroxybutyric acid (GHBA) are specifically induced by activation of GABA_B receptors
Erhardt S; Andersson B; Nissbrandt H; Engberg G
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Disrupted-in-schizophrenia 1 (DISC1) protein aggregates in cerebrospinal fluid are elevated in first-episode psychosis patients
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Corrigendum: MOLECULAR PSYCHIATRY. 2022;27(3):1855
GRK3 deficiency elicits brain immune activation and psychosis (May, 10.1038/s41380-021-01106-0, 2021)
Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hokfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landen M; Engberg G; Erhardt S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:378-379
Proteomic Plasma Profiling of Patients With First-Episode Psychosis Identifies Inflammatory Markers Associated With Illness Severity
Erhardt S; Schwieler L; Sellgren CM; Eren F; Cervenka S; Piehl F; Bergman HF; Orhan F; Engberg G
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:290-291
Dysregulation of the Kynurenine Pathway is Related to Persistent Cognitive Impairments After Tick Borne Encephalitis (TBE)
Schwieler L; Weidenfors JA; Griska V; Li X; Piehl F; Mickiene A; Erhardt S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:277
Inflammation Moderates Antidepressant Response to Ketamine in a Rodent Model of Treatment-Resistant Depression: Bioenergetic and Inflammatory Markers of Response
Tye S; Price JB; Walker A; Kruse J; Cullen K; Frye M; Schwieler L; Erhardt S
Preprint: MEDRXIV. 2021
Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophrenia
Gracias J; Orhan F; Hörbeck E; Holmén-Larsson J; Khanlarkani N; Malwade S; Goparaju S; Schwieler L; Fatourus-Bergman H; Pelanis A; Goold C; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yañez VC; Göpfert J; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan S; Perlis R; Cervenka S; Erhardt S; Landen M; Sellgren C
Letter: SCHIZOPHRENIA RESEARCH. 2019;208:490-492
Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis
Santillo AF; Lundgren S; Xu C; Orhan F; Fatouros-Bergman H; Blennow K; Zetterberg H; Portelius E; Cervenka S; Jonsson EG; Erhardt S; Engberg G
Letter: BIOLOGICAL PSYCHIATRY. 2019;85(7):e35-e39
Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?
van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Clark VP; Mueller BA; de Zwarte SMC; Ophoff RA; van Haren NEM; Andreassen OA; Gurholt TP; Gruber O; Kraemer B; Richter A; Calhoun VD; Crespo-Facorro B; Roiz-Santianez R; Tordesillas-Gutierrez D; Loughland C; Catts S; Fullerton JM; Green MJ; Henskens F; Jablensky A; Mowry BJ; Pantelis C; Quide Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Weickert CS; Weickert TW; Hong E; Kochunov P; Gur RE; Gur RC; Ford JM; Macciardi F; Mathalon DH; Potkin SG; Preda A; Fan F; Ehrlich S; King MD; De Haan L; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; Pomarol-Clotet E; Kelly S; Ciufolini S; Radua J; Murray R; Marques TR; Simmons A; Borgwardt S; Schoenborn-Harrisberger F; Riecher-Roessler A; Smieskova R; Alpert KI; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Yun J-Y; Cannon DM; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; McIntosh AM; Whalley HC; Knoechel C; Oertel-Knoechel V; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA; Farde L; Flyckt L; Fatouros-Bergman H; Cervenka S; Collste K; Victorsson P; Engberg G; Erhardt S; Schwieler L; Malmqvist A; Hedberg M; Orhan F; Piehl F; Agartz I
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2019;44(SUPPL 1):490-491
Role of GRK3 in Brain Immune Activation and Psychosis
Erhardt S; Sellgren CM; Schwieler L; Imbeault S; Engberg G
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2019;44(SUPPL 1):169-170
Synaptic Elimination in First-Episode Psychosis Subjects
Engberg G; Xu C; Sellgren C; Fatouros-Bergman H; Blennow K; Zetterberg H; Brinkmalm A; Erhardt S
Letter: SCHIZOPHRENIA RESEARCH. 2018;199:438-441
Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients
Checa A; Malmqvist A; Flyckt L; Schwieler L; Samuelsson M; Skogh E; Cervenka S; Dahl M-L; Piehl F; Erhardt S; Wheelock CE
Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2018;90:212-220
Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression
Price JB; Bronars C; Erhardt S; Cullen KR; Schwieler L; Berk M; Walder K; McGee SL; Frye MA; Tye SJ
Letter: SCHIZOPHRENIA RESEARCH. 2018;195:406-408
First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction
Orhan F; Fatouros-Bergman H; Schwieler L; Cervenka S; Flyckt L; Sellgren CM; Engberg G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S722
Associations between central chemokine levels and glial activation in first episode psychosis - a positron emission tomography study
Collste K; Orhan F; Erhardt S; Schwieler L; Flyckt L; Farde L; Engberg G; Cervenka S
Preprint: BIORXIV. 2017
Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium
Kong X-Z; Mathias S; Guadalupe T; Abé C; Agartz I; Akudjedu T; Andre A; Saud A; Allen N; Ames D; Andreassen O; Arias Vasquez A; Armstrong N; Bergo F; Bastin M; Batalla A; Bauer J; Baune B; Baur R; Biederman J; Blaine S; Boedhoe P; Bøen E; Bose A; Bralten J; Brandeis D; Brem S; Brodaty H; Bröhl H; Brooks S; Buitelaar J; Bürger C; Bülow R; Calhoun V; Calvo A; Canales-Rodríguez EJ; Canive J; Cannon D; Caparelli E; Castellanos F; Cavalleri G; Cendes F; Chaim-Avancini TM; Chantiluke K; Chen Q-L; Chen X; Cheng Y; Christakou A; Clark V; Coghill D; Connolly C; Conzelmann A; Cόrdova-Palomera A; Cousijn J; Crow T; Cubillo A; Dannlowski U; de Bruttopilo SA; Zeeuw PD; Deary I; Delanty N; Demeter D; Martino AD; Dickie E; Dietsche B; Doan T; Doherty C; Doyle A; Durston S; Earl E; Ehrlich S; Ekman CJ; Elvsåshagen T; Epstein J; Fair D; Faraone S; Fatouros-Bergman H; Fernndez G; Busatto Filho G; Flyckt L; Forster K; Jean-Paul F; Foxe J; Fuentes-Claramonte P; Fullerton J; Garavan H; Garcia DDS; Gotlib I; Goudriaan A; Jorgen Grabe H; Groenewold N; Grotegerd D; Gruber O; Gurholt T; Haavik J; Hahn T; Hansell N; Harris M; Hartman C; Hernandez MDCV; Heslenfeld D; Hester R; Hibar DP; Ho B-C; Ho T; Hoekstra P; van Holst R; Hoogman M; Hovik M; Howells F; Hugdahl K; Huyser C; Ingvar M; Irwin L; Ishikawa A; James A; Jahanshad N; Jernigan T; Jonsson E; Kahler C; Kaleda V; Kelly C; Kerich M; Keshavan M; Khadka S; Kircher T; Kohls G; Konrad K; Korucuoglu O; Kramer B; Krug A; Kwon JS; Lambregts-Rommelse N; Landen M; Lazaro L; Lebedeva I; Lenroot R; Lesch K-P; Li Q; Lim K; Liu J; Lochner C; London E; Lonning V; Lorenzetti V; Luciano M; Luijten M; Lundervold A; Mackey S; MacMaster F; Maingault S; Malpas C; Malt U; Mataix-Cols D; Martin-Santos R; Mayer A; McCarthy H; Mitchell P; Mueller B; Maniega SM; Mazoyer B; McDonald C; McLellan Q; McMahon K; McPhilemy G; Momenan R; Morales A; Narayanaswamy J; Moreira JCV; Nerland S; Nestor L; Nigg J; Nordvik J-E; Novotny S; Oberwelland E; O'Gorman R; Oosterlaan J; Oranje B; Orr C; Overs B; Pauli P; Paulus M; Plessen K; von Polier G; Pomarol-Clotet E; Qiu J; Radua J; Ramos-Quiroga JA; Reddy YCJ; Reif A; Roberts G; Rosa P; Rubia K; Sacchet M; Sachdev P; Salvador R; Schmaal L; Schweren L; Seidman L; Seitz J; Serpa MH; Shaw P; Shumskaya E; Silk T; Simmons A; Simulionyte E; Sinha R; Sjoerds Z; Smelror RE; Soliva JC; Solowij N; Sponheim S; Stein D; Stein E; Stevens M; Strike L; Sudre G; Sui J; Tamm L; Temmingh H; Thoma R; Tomyshev A; Tronchin G; Turner J; Uhlmann A; van Erp TGM; van den Heuvel O; van der Meer D; van Eijk L; Vance A; Veer I; Dic
Conference publication: BIOLOGICAL PSYCHIATRY. 2017;81(10):S266-S267
Metformin Enhances Antidepressant Response Rate to Ketamine in a Rodent Model of Antidepressant Treatment Resistance
Price J; He C; Erhardt S; Schwieler L; Frye M; Tye S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2017;42:S220-S221
First-Episode Psychosis Patients Display Increased Plasma IL-18 That Correlates With Cognitive Dysfunctions
Schwieler L; Orhan F; Fatouros-Bergman H; Cervenka S; Flyckt L; Farde L; Sellgren CM; Engberg G; Erhardt S
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44:S522
Radiosynthesis of 6-[¹⁸F]Fluoro-α-methyl-L-tryptophan - a prospective tracer for in vivo studies of tryptophan metabolism
Vazquez-Romero A; Revunov E; Krasikova R; Moein MM; Cervenka S; Erhardt S; Halldin C; Schou M
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017;37:234
Reduced TSPO levels in drug-naive first episode psychosis patients as measured using PET and [¹¹C]PBR28
Collste K; Plaven-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Review: NEUROPHARMACOLOGY. 2017;112(Pt B):297-306
The kynurenine pathway in schizophrenia and bipolar disorder
Erhardt S; Schwieler L; Imbeault S; Engberg G
Conference publication: BIOLOGICAL PSYCHIATRY. 2016;79(9):338S-339S
An Enzyme in the Kynurenine Pathway That Governs Vulnerability to Develop Suicidal Behavior
Brundin L; Sellgren C; Lim C; Grit J; Palsson E; Landen M; Brundin P; Fuchs D; Postolache T; Traskman-Bendz L; Guillemin G; Erhardt S
Review: LAKARTIDNINGEN. 2015;112:DH34
[New findings about schizophrenia can provide new diagnostics and treatment].
Schalling M; Engberg G; Andreassen O; Erhardt S; Cunningham J; Agartz I; Petrovic P; Cervenka S; Fatouros-Bergman H
Review: ACTA PSYCHIATRICA SCANDINAVICA. 2015;132(3):192-203
The role of inflammation in suicidal behaviour
Brundin L; Erhardt S; Bryleva EY; Achtyes ED; Postolache TT
Conference publication: CANCER RESEARCH. 2015;75:1162
Investigating the NAD metabolome in Ewing Sarcoma
Mutz CN; Schwentner R; Kauer MO; Ban J; Aryee DNT; Erhardt S; Fuchs D; Heitger A; Kovar H
Meeting abstract: EUROPEAN PSYCHIATRY. 2015;30:277
Cognitive Performance in Drug-naive First Episode Schizophrenia (FES) Patients
Fatouros-Bergman H; Cervenka C; Flyckt L; Edman G; Schwieler L; Ikonen P; Collste K; Piehl F; Agartz I; Engberg G; Erhardt S; Farde L
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2015;21:351-352
Cerebrospinal fluid kynurenines in multiple sclerosis: relation to disease course and neurocognitive symptoms
Stahl S; Aeinehband S; Brenner P; Bhat M; Fidock MD; Khademi M; Olsson T; Engberg G; Jokinen J; Erhardt S; Piehl F
Conference publication: DIABETOLOGIA. 2015;58:S300
Acute exercise impacts kynurenine metabolism in type 2 diabetic and healthy people
Mudry JM; Ruas JL; Erhardt S; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Corrigendum: CELL. 2015;160(1-2):351
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression (vol 159, pg 33, 2014)
Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson A; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Conference publication: BIPOLAR DISORDERS. 2014;16:65
An inflammatory pathway linked to psychosis in bipolar disorder
Sellgren C; Kegel ME; Bergen SE; Ekman CJ; Olsson S; Larsson M; Sullivan PF; Sklar P; Purcell S; Smoller JW; Magnusson PKE; Hultman CM; Walther-Jallow L; Svensson CI; Lichtenstein P; Engberg G; Erhardt S; Landen M
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23:S14-S15
Intracerebroventricular administration of interleukin-1β elevates brain kynurenic acid and disrupts prepulse inhibition in C57BL/6 mice
Larsson M; Schwieler L; Engberg G; Powell SB; Erhardt S
Conference publication: BIOLOGICAL PSYCHIATRY. 2013;73(9):152S
Il-8 is Associated with Anxiety in Suicide Attempters
Janelidze S; Suchankova P; Ekman A; Erhardt S; Samuelsson M; Westrin A; Minthon L; Hansson O; Traeskman-Bendz L; Brundin L
Conference publication: BIOLOGICAL PSYCHIATRY. 2013;73(9):34S
The Role of CD44-Hyaluronic Acid Signaling in Response to Stress in Mice and in Suicidal Behavior in Humans
Barzilay R; Ventorp F; Segal H; Aharoni I; Globus R; Weizman A; Naor D; Erhardt S; Lipton J; Traskman-Bendz L; Offen D; Brundin L
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:128-129
Endogenous kynurenic acid induces a reduction in parvalbumin immunoreactivity in the rat frontal cortex
Orhan F; Kegel M; Larsson M; Schwieler L; Erhardt S
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:134
Central interleukin-6 activation in patients with chronic schizophrenia
Schwieler L; Skogh E; Samuelsson M; Kegel M; Erhardt S; Engberg G
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:128
Kynurenic acid in cerebrospinal fluid, plasma and urine of healthy male volunteers
Olsson S; Samuelsson M; Erhardt S
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:228
Association between IL-8 and anxiety in suicidal patients
Janelidze S; Suchankova P; Ekman A; Erhardt S; Westrin A; Traskman-Bendz L; Brundin L
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:180
CSF biomarkers in suicide attempters - inflammation biomarkers and monoamine metabolites
Lindqvist D; Janelidze S; Erhardt S; Traskman-Bendz L; Engstrom G; Brundin L
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:179
IL-1β induces TDO and provokes the release of kynurenic acid from human astrocytes in vitro
Kegel ME; Svensson CI; Erhardt S
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:28
Inflammation as a cause of suicidality?
Brundin L; Erhardt S; Traskman-Bendz L
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:117
Significance of elevated brain kynurenic acid following neonatal influenza A infection
Holtze M; Powell SB; Asp L; Karlsson H; Erhardt S
Letter: SCHIZOPHRENIA RESEARCH. 2011;127(1-3):270-272
Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: An association study
Holtze M; Saetre P; Erhardt S; Schwieler L; Werge T; Hansen T; Nielsen J; Djurovic S; Melle I; Andreassen OA; Hall H; Terenius L; Agartz I; Engberg G; Jonsson EG; Schalling M
Conference publication: BIPOLAR DISORDERS. 2011;13:87
Plasticity related gene 5, kynurenic acid, and psychotic features in bipolar disorder
Sellgren C; Olsson S; Lichtenstein P; Erhardt S; Engberg G; Grankvist A; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S40
Neonatal influenza A infection potentiates amphetamine induced increase in locomotor activity in the adult mouse
Holtze M; Asp L; Karlsson H; Erhardt S
Letter: MOLECULAR PSYCHIATRY. 2009;14(12):1069-1071
Activation of brain interleukin-1β in schizophrenia
Soderlund J; Schroeder J; Nordin C; Samuelsson M; Walther-Jallow L; Karlsson H; Erhardt S; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S178
Do virus infections cause schizophrenia?
Karlsson H; Asp L; Ogren SO; Erhardt S; Holtze M; Kristensson K; Dalman C
Review: CNS DRUGS. 2009;23(2):91-101
Pharmacological Manipulation of Kynurenic Acid Potential in the Treatment of Psychiatric Disorders
Erhardt S; Olsson SK; Engberg G
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2008;11:180
Kynurenic acid levels are increased in the cerebrospinal fluid of patients with bipolar disorder
Olsson S; Erhardt S; Engberg G; Landen M
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S422-S423
Enhanced amphetamine-induced dopamine release in rat nucleus accumbens following subchronic elevation of kynurenic acid
Andersson LA; Nilsson LK; Schwieler L; Holtze M; Olsson SK; Olsson E; Linderholm K; Engberg G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S419-S420
Subchronic elevation of endogenous levels of kynurenic acid increase dopamine release in rat nucleus accumbens
Nilsson-Todd LK; Andersson LA; Schwieler L; Engberg G; Holtze M; Linderholm KR; Olsson E; Olsson SK; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S219
Endogenous kynurenate regulates dopaminergic activity: implications for schizophrenia research
Erhardt S; Schwieler L; Nilsson LK; Andersson LA; Linderholm KR; Holtze M; Olsson E; Olsson SK; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S264-S265
Increased midbrain dopaminergic firing by the competitive N-methyl-D-aspartate receptor antagonist SDZ 220-581
Olsson SK; Linderholm K; Erhardt S; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S435-S436
The response of clozapine on midbrain dopamine neurons depends on endogenous concentration of kynurenic acid
Schwieler L; Linderholm KR; Nilsson LK; Engberg G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S377
Correlations between cerebrospinal fluid kynurenic acid and monoamine metabolites in male patients with schizophrenia
Erhardt S; Nordin C; Skogh E; Jonsson EG; Nilsson LK
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):328-329
In situ produced 7-chlorokynurenic acid increase phasic activity of dopaminergic neurons in the rat ventral tegmental area
Andersson LA; Linderholm KR; Eggertson CJ; Schwarcz R; Engberg G; Erhardt S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2006;31:S126
Changes in brain kynurenic acid levels alter the response of clozapine on midbrain dopamine neurons
Engberg G; Erhardt S; Linderholm K; Nilsson L; Schwieler L
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2006;31:S45
Role of endogenous kynurenic acid in the control of dopaminergic neurotransmission
Erhardt S; Schwieler L; Linderholm K; Nilsson L; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):334
Changes in brain kynurenic acid levels alter the response of clozapine on midbrain dopamine neurons
Linderholm KR; Erhardt S; Nilsson LK; Schwieler L; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):321
Kynurenic acid in schizophrenia
Erhardt S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2006;31:S45-S46
Developing a model of kynurenic acid effects on information processing
Powell SB; Erhardt S; Nilsson LK; Linderholm KR; Swerdlow NR; Geyer MA
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S34-S35
Rats reared in social isolation display disrupted ppi and elevated levels of kynurenic acid in the hippocampus
Erhardt S; Powell SB; Nilsson LK; Linderholm KR; Swerdlow NR; Geyer MA
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2005;59(5):409
Kynurenate tonically modulates midbrain dopamine neurons
Erhardt S; Schwieler L; Linderholm KR; Nilsson LK; Engberg G
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S320
Rats reared in social isolation display disrupted PPI and elevated levels of kynurenic acid in the hippocampus
Erhardt S; Swerdlow NR; Powell SB; Nilsson LK; Linderholm KR; Geyer MA
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2005;59(5):416-417
Kynurenic acid levels in cerebrospinal fluid from schizophrenic patients.
Nilsson LK; Linderholm KR; Sedvall G; Engberg G; Erhardt S
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2005;59(5):414
Increased kynurenate in the brain of rats reared in social isolation.
Linderholm KR; Erhardt S; Powell SB; Nilsson LK; Swerdlow N; Geyer MA
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2004;58(2):106-107
Prostaglandin-mediated control of rat brain kynurenic acid synthesis - opposite actions by COX-1 and COX-2 isoforms
Schwieler L; Erhardt S; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2004;58(2):102
Clozapine affects noradrenergic locus coerulcus neurons via interactions with the NMDA receptor
Erhardt S; Nilsson LK; Schwieler L; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2004;58(2):94
Elevation of the endogenous NMDA-receptor antagonist kynurenic acid disrupts prepulse inhibition
Erhardt S; Schwieler L; Geyer M
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2003;527:155-165
Kynurenic acid and schizophrenia
Erhardt S; Schwieler L; Engberg G
Thesis / dissertation: 2001
Importance of endogenous kynurenic acid in brainm catecholaminergic processes and in the pathophysiology of schizophrenia
Erhardt, Sophie
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2001;55(2):90
Excitatory and inhibitory effects of nicotine on neuronal firing of A10 dopamine neurons are mediated via glutamate-and GABA-release, respectively
Erhardt S; Schwieler LH; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2001;55(2):89
The intravenous anesthetic agent propofol induces regularization of the firing pattern and prevents burst activity of nigral dopamine neurons via a GABAB-receptor agonistic action
Engberg G; Erhardt S; Schwieler LH
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2000;54(2):93
Endogenous kynurenic acid blocks nicotine-induced activation of brain dopaminergic and noradrenergic neurons
Erhardt S; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 1999;53(2):110
Increased tiring rate and burst activity of nigral dopamine neurons by the gamma-butyric acid receptor antagonist SCH 50911
Erhardt S; Engberg G
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 1998;52(2):135
γ-hydroxybutyric acid inhibits firing rate and regularizes firing pattern of nigral dopamine neurons specifically by activation of gamma-aminobutyric acid β-receptors
Erhardt S; Engberg G
Visa fler

Forskningsbidrag

Integrated understanding of the pathophysiology in severe psychiatric disorders – a translational approach with focus on immune activation.
Swedish Research Council
1 January 2022 - 31 December 2024
The effect of psilocybin on depression symptom severity, peripheral biomarkers and synaptic density – a single dose randomized double blind, placebo-controlled phase 2 PET study
Swedish Research Council
1 January 2022 - 31 December 2024
Generation of enzyme inhibitors for the treatment of immune-induced psychosis and cognitive deficits
Novo Nordisk Foundation
1 August 2021 - 31 July 2022
A novel immunological approach in the treatment of schizophrenia – drug development, clinical and experimental evaluations
Swedish Research Council
1 January 2020 - 31 December 2023
61st Annual Meeting of Scandinavian College of Neuropsychopharmacology (SCNP)
Swedish Research Council
1 November 2019 - 30 November 2019
Unraveling the Complexity of Psychiatric disorders
Swedish Research Council
1 January 2018 - 31 December 2021
MRI brain morphology and connectivity in schizophrenia; translational studies of four cohorts; importance of genetic and non-genetic risk factors for brain development and clinical outcome
Swedish Research Council
1 January 2018 - 31 December 2020
Affective disorders- A translational and prospective approach to dimensional etiology and treatment response
Swedish Research Council
1 January 2017 - 31 December 2019
Unraveling the Immune Architecture of Schizophrenia
Swedish Research Council
1 January 2014 - 31 December 2017
Towards an understanding of gliotransmission in psychiatric disorders - role of neuroimmunology
Swedish Research Council
1 January 2012 - 31 December 2013
Brain immune activation in schizophrenia - functional investigations of a novel antipsychotic drug target
Swedish Research Council
1 January 2012 - 31 December 2013
Towards an understanding of gliotransmission in psychiatric disorders - Role of neuroimmunology
Swedish Research Council
1 September 2010 - 31 August 2016
Towards an understanding of gliotransmission in psychiatric disorders - Role of neuroimmunology
Swedish Research Council
1 September 2010 - 31 August 2016
Towards an understanding of gliotransmission in psychiatric disorders - role of neuroimmunology
Swedish Research Council
1 January 2010 - 31 December 2011
Brain Immune actvation in schizophrenia
Swedish Research Council
1 January 2009 - 31 December 2012

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Professor, Fysiologi och farmakologi, Karolinska Institutet, 2016-

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Docent, Farmakologi, Karolinska Institutet, 2006
MEDICINE DOKTORSEXAMEN, Institutionen för fysiologi och farmakologi, Karolinska Institutet, 2001

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Prefekt, Fysiologi och farmakologi, Karolinska Institutet, 2022-

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