Sara Hägg

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Jag är docent i molekylär epidemiologi vid Institutionen för medicinsk epidemiologi och biostatistik på Karolinska Institutet och min forskning handlar om åldrandet. Jag använder bland annat data från Svenska Tvillingregistret och UK biobank för att titta på biologiskt åldrande och associationer med åldersrelaterade sjukdomar.

Utbildning
* PhD i beräkningsbiologi, Linköpings universitet, 2009
* MSc i molekylärbiologi, Stockholms universitet, 2003
* BSc i datavetenskap, Stockholms universitet, 2003
Postdoc
* Genetisk epidemiologi, Medicinsk epidemiologi och biostatistik (MEB), KI, 2011-2014
* Molekylär epidemiologi, Institutionen för medicinska vetenskaper, Uppsala universitet, 2013-2014
Sabbatical
* Stanford University School of Medicine, 2016

Forskningsbeskrivning

Gå till engensk sida och gruppsidan för mer information.

Artiklar

Article: GEROSCIENCE. 2024;46(5):5003-5014
Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study
Shemer DW; Mostafaei S; Tang B; Pedersen NL; Karlsson IK; Fall T; Hagg S
Journal article: GEROSCIENCE. 2024;:1-14
Comprehensive analysis of molecular, physiological, and functional biomarkers of aging with neurological diseases using Mendelian randomization
Imahori Y; Qin C; Tang B; Haegg S
Article: BMJ MENTAL HEALTH. 2024;27(1):e301064
Association between psychological resilience and all-cause mortality in the Health and Retirement Study
Zhang A; Zhou L; Meng Y; Ji Q; Ye M; Liu Q; Tan W; Zheng Y; Hu Z; Liu M; Xu X; Karlsson IK; Hagg S; Zhan Y
Article: GEROSCIENCE. 2024;:1-18
Biological aging of different blood cell types
Marttila S; Rajic S; Ciantar J; Mak JKL; Junttila IS; Kummola L; Hagg S; Raitoharju E; Kananen L
Article: NATURE AGING. 2024;4(7):1014-1027
Deep learning-based prediction of one-year mortality in Finland is an accurate but unfair aging marker
Vabalas A; Hartonen T; Vartiainen P; Jukarainen S; Viippola E; Rodosthenous RS; Liu A; Hagg S; Perola M; Ganna A
Article: ECLINICALMEDICINE. 2024;73:102689
Comparative effectiveness of glucagon-like peptide-1 agonists, dipeptidyl peptidase-4 inhibitors, and sulfonylureas on the risk of dementia in older individuals with type 2 diabetes in Sweden: an emulated trial study
Tang B; Sjolander A; Wastesson JW; Maura G; Blotiere P-O; Szilcz M; Mak JKL; Qin C; Alvarsson M; Religa D; Johnell K; Hagg S
Article: AMERICAN JOURNAL OF KIDNEY DISEASES. 2024;83(6):772-783.e1
Kidney Function Measures and Mortality: A Mendelian Randomization Study
Shan Y; Zhang J; Lu Y; Liao J; Liu Y; Dai L; Li J; Song C; Su G; Hagg S; Xiong Z; Nitsch D; Carrero JJ; Huang X
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2024;39(6):667-678
Metabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility
Wei Y; Hagg S; Mak JKL; Tuomi T; Zhan Y; Carlsson S
Article: AGING CELL. 2024;23(6):e14132
Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden
De Oliveira TL; Tang B; Bai G; Sjolander A; Jylhava J; Finkel D; Pedersen NL; Hassing LB; Reynolds CA; Karlsson IK; Hagg S
Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(6):754-769
Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease.
Bergstedt J; Pasman JA; Ma Z; Harder A; Yao S; Parker N; Treur JL; Smit DJA; Frei O; Shadrin AA; Meijsen JJ; Shen Q; Hägg S; Tornvall P; Buil A; Werge T; Hjerling-Leffler J; Als TD; Børglum AD; Lewis CM; McIntosh AM; Valdimarsdóttir UA; Andreassen OA; Sullivan PF; Lu Y; Fang F
Article: AGING CELL. 2024;23(6):e14135
Epigenome-wide analysis of frailty: Results from two European twin cohorts
Mak JKL; Skovgaard AC; Nygaard M; Kananen L; Reynolds CA; Wang Y; Kuja-Halkola R; Karlsson IK; Pedersen NL; Hagg S; Soerensen M; Jylhava J
Article: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. 2024;11(6):1393-1404
Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis
Kowalec K; Harder A; Dolovich C; Fitzgerald KC; Salter A; Lu Y; Bernstein CN; Bolton JM; Cutter G; Fisk JD; Gelernter J; Graff LA; Haegg S; Hitchon CA; Levey DF; Lublin FD; Mckay KA; Patten S; Patki A; Stein MB; Tiwari HK; Wolinsky JS; Marrie RA
Article: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. 2024;95(5):481-484
Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank
Mak JKL; McMurran CE; Hagg S
Article: STATISTICS IN MEDICINE. 2024;43(4):731-755
Combining Mendelian randomization with the sibling comparison design
Sjolander A; Frisell T; Oberg S; Wang Y; Hagg S
Article: GEROSCIENCE. 2024;46(1):961-968
Associations between psychological resilience and epigenetic clocks in the health and retirement study
Zhang A; Zhang Y; Meng Y; Ji Q; Ye M; Zhou L; Liu M; Yi C; Karlsson IK; Fang F; Haegg S; Zhan Y
Article: HELIYON. 2024;10(1):e23415
Genetically determined telomere length and its association with chronic obstructive pulmonary disease and interstitial lung disease in biobank Japan: A Mendelian randomization study
Zhu Y; Meng Y; Zhang Y; Karlsson IK; Hagg S; Zhan Y
Article: NEUROEPIDEMIOLOGY. 2024;58(4):256-263
Associations between Sleep Disorders and Impulsive-Compulsive Behaviors in Parkinson's Disease: A Prospective Cohort Study
Ye M; Kang X; Karlsson IK; Wang Y; Ji Q; Liu Q; Xu X; Hagg S; Fang F; Wirdefeldt K; Zhan Y
Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(6):754-769
Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease
Bergstedt J; Pasman JA; Ma Z; Harder A; Yao S; Parker N; Treur JL; Smit DJA; Frei O; Shadrin AA; Meijsen JJ; Shen Q; Hagg S; Tornvall P; Buil A; Werge T; Hjerling-Leffler J; Als TD; Borglum AD; Lewis CM; Mcintosh AM; Valdimarsdottir UA; Andreassen OA; Sullivan PF; Lu Y; Fang F
Article: EPIGENETICS. 2023;18(1):2158285
Leukocyte DNA methylation in Alzheimer′s disease associated genes: replication of findings from neuronal cells
Karlsson IK; Ploner A; Wang Y; Gatz M; Pedersen NL; Haegg S
Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2023;11(12):e2255
Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population
Li X; Ploner A; Wang Y; Mak JKL; Lu Y; Magnusson PKE; Jylhava J; Hagg S
Article: BRAIN. 2023;146(12):4891-4902
Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings
Mcmurran CE; Wang Y; Mak JKL; Karlsson IK; Tang B; Ploner A; Pedersen NL; Hagg S
Article: HEALTH SCIENCE REPORTS. 2023;6(11):e1692
Anticoagulant treatment and COVID-19 mortality among older adults living in nursing homes in Sweden
Kananen L; Molnar C; Ansker F; Kozlowska DJ; Hagg S; Jylhava J; Religa D; Raaschou P
Article: NEUROLOGY. 2023;101(5):e522-e532
Polygenicity of Comorbid Depression in Multiple Sclerosis
Kowalec K; Fitzgerald KC; Salter A; Dolovich C; Harder A; Bernstein CN; Bolton J; Cutter GR; Graff LA; Hagg S; Hitchon CA; Lu Y; Lublin F; McKay KA; Patten SB; Patki A; Tiwari HK; Wolinsky JS; Marrie RA
Article: AGING CELL. 2023;22(8):e13868
Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses
Mak JKL; Kananen L; Qin C; Kuja-Halkola R; Tang B; Lin J; Wang Y; Jaaskelainen T; Koskinen S; Lu Y; Magnusson PKE; Hagg S; Jylhava J
Article: BRITISH JOURNAL OF CANCER. 2023;129(1):94-103
Clinical biomarker-based biological aging and risk of cancer in the UK Biobank
Mak JKL; McMurran CE; Kuja-Halkola R; Hall P; Czene K; Jylhaevae J; Haegg S
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2023;38(7):809-819
Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study
Qin C; Diaz-Gallo L-M; Tang B; Wang Y; Nguyen T-D; Harder A; Lu Y; Padyukov L; Askling J; Hagg S
Article: NEUROBIOLOGY OF AGING. 2023;126:103-112
Independent role of Alzheimer?s disease genetics and C-reactive protein on cognitive ability in aging
Supiyev A; Karlsson R; Wang Y; Koch E; Hagg S; Kauppi K
Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2023;51(4):587-594
Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA)
Wennberg AM; Yin W; Fang F; Pedersen NL; Hagg S; Jylhava J; Modig K
Article: GEROSCIENCE. 2023;45(3):2065-2078
Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging
Tang B; Li X; Wang Y; Sjolander A; Johnell K; Thambisetty M; Ferrucci L; Reynolds CA; Finkel D; Jylhava J; Pedersen NL; Hagg S
Article: GEROSCIENCE. 2023;45(3):2051-2064
Can frailty scores predict the incidence of cancer? Results from two large population-based studies
Mak JKL; Kuja-Halkola R; Wang Y; Haegg S; Jylhaevae J
Article: CARDIOVASCULAR RESEARCH (CVR). 2023;119(4):998-1007
Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study
Luo J; Noordam R; Jukema JW; van Dijk KW; Hagg S; Grassmann F; le Cessie S; van Heemst D
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(3):316-323
Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking
Tang B; Liu Q; Ilar A; Wiebert P; Hagg S; Padyukov L; Klareskog L; Alfredsson L; Jiang X
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(2):333-341
Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age
Mak JKL; Kuja-Halkola R; Bai G; Hassing LB; Pedersen NL; Hagg S; Jylhava J; Reynolds CA
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2023;15(1):5
Dementia and psychotropic medications are associated with significantly higher mortality in geriatric patients hospitalized with COVID-19: data from the StockholmGeroCovid project.
Secnik J; Eriksdotter M; Xu H; Annetorp M; SweGeroCOVID Project; Rytarowski A; Johnell K; Hägg S; Religa D
Article: EPIGENETICS COMMUNICATIONS. 2023;3(1):7
Connections between cross-tissue and intra-tissue biomarkers of aging biology in older adults.
Waziry R; Gu Y; Williams O; Hägg S
Article: PLOS ONE. 2023;18(3):e0283344
Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden
Kananen L; Hong X; Annetorp M; Mak JKL; Jylhava J; Eriksdotter M; Hagg S; Religa D
Article: GERONTOLOGY. 2023;69(4):396-405
Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study
Mak JKL; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Bostrom A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engstrom M; Johnson P; Lundberg LG; Akesson E; Oberg CS; Olsson M; Cederholm T; Hagg S; Religa D; Jylhava J
Article: GERONTOLOGY. 2023;69(12):1385-1393
Is Frailty Different in Younger Adults Compared to Old? Prevalence, Characteristics, and Risk Factors of Early-Life and Late-Life Frailty in Samples from Sweden and UK
Bai G; Wang Y; Mak JKL; Ericsson M; Hagg S; Jylhava J
Article: CLINICAL NUTRITION. 2022;41(12):2973-2979
Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19
Kananen L; Eriksdotter M; Bostrom AM; Kivipelto M; Annetorp M; Metzner C; Jerlardtz VB; Engstrom M; Johnson P; Lundberg LG; Akesson E; Oberg CS; Hagg S; Religa D; Jylhava J; Cederholm T
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2022;37(12):1261-1271
Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels
Karlsson IK; Zhan Y; Wang Y; Li X; Jylhava J; Hagg S; Aslan AKD; Gatz M; Pedersen NL; Reynolds CA
Article: CLINICAL EPIGENETICS. 2022;14(1):153
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy
Qin X; Wang Y; Pedersen NL; Tang B; Hagg S
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(11):2311-2319
Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden
Mak JKL; Hagg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Bostrom A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engstrom M; Johnson P; Lundberg LG; Akesson E; Oberg CS; Olsson M; Cederholm T; Jylhava J; Religa D
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:e198
T55. POLYGENICITY OF COMORBID DEPRESSION IN MULTIPLE SCLEROSIS
Kowalec K; Salter A; Fitzgerald KC; Harder A; Lu Y; Dolovich C; Hägg S; Hitchon C; Bernstein CN; Cutter G; Bolton JM; McKay K; Graff LA; Patten S; Marrie RA
Article: DIABETOLOGIA. 2022;65(10):1676-1686
Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study
Wang W; Luo J; Willems van Dijk K; Hagg S; Grassmann F; 't Hart LM; van Heemst D; Noordam R
Article: EPIGENOMICS. 2022;14(18):1105-1124
Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues
Marttila S; Tamminen H; Rajic S; Mishra PP; Lehtimaki T; Raitakari O; Kahonen M; Kananen L; Jylhava J; Hagg S; Delerue T; Peters A; Waldenberger M; Kleber ME; Marz W; Luoto R; Raitanen J; Sillanpaa E; Laakkonen EK; Heikkinen A; Ollikainen M; Raitoharju E
Article: NEUROLOGY. 2022;99(7):e650-e659
Genetic Variation in Targets of Antidiabetic Drugs and Alzheimer Disease Risk A Mendelian Randomization Study
Tang B; Wang Y; Jiang X; Thambisetty M; Ferrucci L; Johnell K; Hagg S
Article: ATHEROSCLEROSIS. 2022;354:1-7
The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses
Martens LG; Luo J; Wermer MJH; van Dijk KW; Hagg S; Grassmann F; Noordam R; van Heemst D
Article: NATURE AGING. 2022;2(7):644-661
A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking
Higgins-Chen AT; Thrush KL; Wang Y; Minteer CJ; Kuo P-L; Wang M; Niimi P; Sturm G; Lin J; Moore AZ; Bandinelli S; Vinkers CH; Vermetten E; Rutten BPF; Geuze E; Okhuijsen-Pfeifer C; van der Horst MZ; Schreiter S; Gutwinski S; Luykx JJ; Picard M; Ferrucci L; Crimmins EM; Boks MP; Haegg S; Hu-Seliger TT; Levine ME
Article: NATURE GENETICS. 2022;54(5):581-592
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Howe LJ; Nivard MG; Morris TT; Hansen AF; Rasheed H; Cho Y; Chittoor G; Ahlskog R; Lind PA; Palviainen T; van der Zee MD; Cheesman R; Mangino M; Wang Y; Li S; Klaric L; Ratliff SM; Bielak LF; Nygaard M; Giannelis A; Willoughby EA; Reynolds CA; Balbona JV; Andreassen OA; Ask H; Baras A; Bauer CR; Boomsma DI; Campbell A; Campbell H; Chen Z; Christofidou P; Corfield E; Dahm CC; Dokuru DR; Evans LM; de Geus EJC; Giddaluru S; Gordon SD; Harden KP; Hill WD; Hughes A; Kerr SM; Kim Y; Kweon H; Latvala A; Lawlor DA; Li L; Lin K; Magnus P; Magnusson PKE; Mallard TT; Martikainen P; Mills MC; Njolstad PR; Overton JD; Pedersen NL; Porteous DJ; Reid J; Silventoinen K; Southey MC; Stoltenberg C; Tucker-Drob EM; Wright MJ; Kweon H; Hewitt JK; Keller MC; Stallings MC; Lee JJ; Christensen K; Kardia SLR; Peyser PA; Smith JA; Wilson JF; Hopper JL; Hagg S; Spector TD; Pingault J-B; Plomin R; Havdahl A; Bartels M; Martin NG; Oskarsson S; Justice AE; Millwood IY; Hveem K; Naess O; Willer CJ; Asvold BO; Koellinger PD; Kaprio J; Medland SE; Walters RG; Benjamin DJ; Turley P; Evans DM; Smith GD; Hayward C; Brumpton B; Hemani G; Davies NM
Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):124
Genetics of age-at-onset in major depression
Harder A; Thuy-Dung N; Pasman JA; Mosing MA; Hagg S; Lu Y
Article: MOLECULAR PSYCHIATRY. 2022;27(3):1667-1675
Genetic heterogeneity and subtypes of major depression
Thuy-Dung N; Harder A; Xiong Y; Kowalec K; Hagg S; Cai N; Kuja-Halkola R; Dalman C; Sullivan PF; Lu Y
Journal article: NPJ PARKINSON'S DISEASE. 2022;8(1):14
Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients
Meoni G; Tenori L; Schade S; Licari C; Pirazzini C; Bacalini MG; Garagnani P; Turano P; Trenkwalder C; Franceschi C; Mollenhauer B; Luchinat C
Article: SCIENTIFIC REPORTS. 2022;12(1):1330
Early downregulation of hsa-miR-144-3p in serum from drug-naive Parkinson's disease patients
Zago E; Dal Molin A; Dimitri GM; Xumerle L; Pirazzini C; Bacalini MG; Maturo MG; Azevedo T; Spasov S; Gomez-Garre P; Perinan MT; Jesus S; Baldelli L; Sambati L; Calandra-Buonaura G; Garagnani P; Provini F; Cortelli P; Mir P; Trenkwalder C; Mollenhauer B; Franceschi C; Lio P; Nardini C
Article: JOURNAL OF NUTRITION. 2022;152(1):269-275
Protein Nutritional Status and Frailty: A Mendelian Randomization Study
Tomata Y; Wang Y; Hagg S; Jylhava J
Article: PAIN. 2022;163(1):e40-e48
Reciprocal interaction between depression and pain: results from a comprehensive bidirectional Mendelian randomization study and functional annotation analysis
Tang B; Meng W; Hagg S; Burgess S; Jiang X
Article: AGE AND AGEING. 2021;50(6):2174-2182
Frailty trajectories in three longitudinal studies of aging: Is the level or the rate of change more predictive of mortality?
Bai G; Szwajda A; Wang Y; Li X; Bower H; Karlsson IK; Johansson B; Aslan AKD; Pedersen NL; Hagg S; Jylhava J
Article: BMC MEDICINE. 2021;19(1):248
Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?
Bai G; Wang Y; Kuja-Halkola R; Li X; Tomata Y; Karlsson IK; Pedersen NL; Hagg S; Jylhava J
Article: NUTRIENTS. 2021;13(10):3539
Fatty Acids and Frailty: A Mendelian Randomization Study
Tomata Y; Wang Y; Hagg S; Jylhava J
Journal article: NPJ PARKINSON'S DISEASE. 2021;7(1):78
Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients
Baldelli L; Schade S; Jesus S; Schreglmann SR; Sambati L; Gomez-Garre P; Halsband C; Calandra-Buonaura G; Daniela Adarmes-Gomez A; Sixel-Doering F; Zenesini C; Pirazzini C; Garagnani P; Bacalini MG; Bhatia KP; Cortelli P; Mollenhauer B; Franceschi C; Mir P; Trenkwalder C; Provini F
Article: AGING CELL. 2021;20(9):e13459
A genome-wide association study of the frailty index highlights brain pathways in ageing
Atkins JL; Jylhava J; Pedersen NL; Magnusson PK; Lu Y; Wang Y; Hagg S; Melzer D; Williams DM; Pilling LC
Article: AGING. 2021;13(13):16990-17023
Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education
Mak JKL; Reynolds CA; Hagg S; Li X; Ericsson M; Pedersen NL; Jylhava J; Kuja-Halkola R
Article: GENOME BIOLOGY. 2021;22(1):194
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
McCartney DL; Min JL; Richmond RC; Lu AT; Sobczyk MK; Davies G; Broer L; Guo X; Jeong A; Jung J; Kasela S; Katrinli S; Kuo P-L; Matias-Garcia PR; Mishra PP; Nygaard M; Palviainen T; Patki A; Raffield LM; Ratliff SM; Richardson TG; Robinson O; Soerensen M; Sun D; Tsai P-C; van der Zee MD; Walker RM; Wang X; Wang Y; Xia R; Xu Z; Yao J; Zhao W; Correa A; Boerwinkle E; Dugue P-A; Durda P; Elliott HR; Gieger C; de Geus EJC; Harris SE; Hemani G; Imboden M; Kahonen M; Kardia SLR; Kresovich JK; Li S; Lunetta KL; Mangino M; Mason D; McIntosh AM; Mengel-From J; Moore AZ; Murabito JM; Ollikainen M; Pankow JS; Pedersen NL; Peters A; Polidoro S; Porteous DJ; Raitakari O; Rich SS; Sandler DP; Sillanpaa E; Smith AK; Southey MC; Strauch K; Tiwari H; Tanaka T; Tillin T; Uitterlinden AG; van den Berg DJ; van Dongen J; Wilson JG; Wright J; Yet I; Arnett D; Bandinelli S; Bell JT; Binder AM; Boomsma DI; Chen W; Christensen K; Conneely KN; Elliott P; Ferrucci L; Fornage M; Hagg S; Hayward C; Irvin M; Kaprio J; Lawlor DA; Lehtimaki T; Lohoff FW; Milani L; Milne RL; Probst-Hensch N; Reiner AP; Ritz B; Rotter J; Smith JA; Taylor JA; van Meurs JBJ; Vineis P; Waldenberger M; Deary IJ; Relton CL; Horvath S; Marioni RE
Article: CLINICAL EPIGENETICS. 2021;13(1):129
The epigenetic etiology of cardiovascular disease in a longitudinal Swedish twin study
Qin X; Karlsson IK; Wang Y; Li X; Pedersen N; Reynolds CA; Hagg S
Article: NATURE COMMUNICATIONS. 2021;12(1):3417
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
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Article: MOLECULAR PSYCHIATRY. 2021;26(6):2148-2162
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
van Dongen J; Hagenbeek FA; Suderman M; Roetman PJ; Sugden K; Chiocchetti AG; Ismail K; Mulder RH; Hafferty JD; Adams MJ; Walker RM; Morris SW; Lahti J; Kupers LK; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip HF; Jansen R; Baselmans BML; Parmar P; Lowry E; Streit F; Sirignano L; Send TS; Frank J; Jylhava J; Wang Y; Mishra PP; Colins OF; Corcoran DL; Poulton R; Mill J; Hannon E; Arseneault L; Korhonen T; Vuoksimaa E; Felix JF; Bakermans-Kranenburg MJ; Campbell A; Czamara D; Binder E; Corpeleijn E; Gonzalez JR; Grazuleviciene R; Gutzkow KB; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; Kluft C; Davies GE; Hakulinen C; Keltikangas-Jarvinen L; Franke B; Freitag CM; Konrad K; Hervas A; Fernandez-Rivas A; Vetro A; Raitakari O; Lehtimaki T; Vermeiren R; Strandberg T; Raikkonen K; Snieder H; Witt SH; Deuschle M; Pedersen NL; Hagg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt TE; Tiemeier H; van IJzendoorn MH; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans KL; McIntosh AM; Bartels M; Boomsma DI
Article: HUMAN GENETICS. 2021;140(6):849-861
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance
Hagg S; Jylhava J; Wang Y; Czene K; Grassmann F
Article: GEROSCIENCE. 2021;43(3):1519-1525
Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study
Zhan Y; Hagg S
Article: EPIGENOMICS. 2021;13(12):939-951
Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study
Lu M; Xueying Q; Hexiang P; Wenjing G; Hagg S; Weihua C; Chunxiao L; Canqing Y; Jun L; Zengchang P; Liming C; Hua W; Xianping W; Yunzhang W; Liming L
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2021;69(5):1128-1139
Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: The effect of sampling
Mak JKL; Kuja-Halkola R; Wang Y; Hagg S; Jylhava J
Article: CLINICAL EPIGENETICS. 2021;13(1):85
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life
Karlsson IK; Ericsson M; Wang Y; Jylhava J; Hagg S; Aslan AKD; Reynolds CA; Pedersen NL
Article: EBIOMEDICINE. 2021;66:103318
Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data
Li X; Ploner A; Wang Y; Zhan Y; Pedersen NL; Magnusson PK; Jylhava J; Hagg S
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2021;194:111426
A geroscience approach for Parkinson ' s disease: Conceptual framework and design of PROPAG-AGEING project
Pirazzini C; Azevedo T; Baldelli L; Bartoletti-Stella A; Calandra-Buonaura G; Dal Molin A; Dimitri GM; Doykov I; Gomez-Garre P; Hagg S; Hallqvist J; Halsband C; Heywood W; Jesus S; Jylhava J; Kwiatkowska KM; Labrador-Espinosa MA; Licari C; Maturo MG; Mengozzi G; Meoni G; Milazzo M; Perinan-Tocino MT; Ravaioli F; Sala C; Sambati L; Schade S; Schreglmann S; Spasov S; Tenori L; Williams D; Xumerle L; Zago E; Bhatia KP; Capellari S; Cortelli P; Garagnani P; Houlden H; Lio P; Luchinat C; Delledonne M; Mills K; Mir P; Mollenhauer B; Nardini C; Pedersen NL; Provini F; Strom S; Trenkwalder C; Turano P; Bacalini MG; Franceschi C
Article: FRONTIERS IN RESEARCH METRICS AND ANALYTICS. 2021;6:594424
Gender Bias Impacts Top-Merited Candidates.
Andersson ER; Hagberg CE; Hägg S
Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2020;21(11):1555-1559.e2
Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care
Hagg S; Jylhava J; Wang Y; Xu H; Metzner C; Annetorp M; Garcia-Ptacek S; Khedri M; Bostrom A-M; Kadir A; Johansson A; Kivipelto M; Eriksdotter M; Cederholm T; Religa D
Article: LIFE SCIENCE ALLIANCE. 2020;3(10):e202000817
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality
Hong M-G; Dodig-Crnkovic T; Chen X; Drobin K; Lee W; Wang Y; Edfors F; Kotol D; Thomas CE; Sjoberg R; Odeberg J; Hamsten A; Silveira A; Hall P; Nilsson P; Pawitan Y; Uhlen M; Pedersen NL; Hagg S; Magnusson PK; Schwenk JM
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2020;75(10):1943-1950
Drivers of Frailty from Adulthood into Old Age: Results from a 27-Year Longitudinal Population-Based Study in Sweden
Raymond E; Reynolds CA; Aslan AKD; Finkel D; Ericsson M; Hagg S; Pedersen NL; Jylhava J
Article: AGING CELL. 2020;19(8):e13197
A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation
Reynolds CA; Tan Q; Munoz E; Jylhava J; Hjelmborg J; Christiansen L; Hagg S; Pedersen NL
Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(2):234-247
Joint impact of common risk factors on incident dementia: A cohort study of the Swedish Twin Registry
Tomata Y; Li X; Karlsson IK; Mosing MA; Pedersen NL; Hagg S
Article: PSYCHOSOMATIC MEDICINE. 2020;82(6):614-622
The Association of Individual Changes in Stressful Life Events and Telomere Length Over Time in Twins 50 Years and Older
Gerritsen L; Hagg S; Reynolds CA; Pedersen NL
Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(6):1397-1405
Replicating associations between DNA methylation and body mass index in a longitudinal sample of older twins
Karlsson IK; Ericsson M; Wang Y; Jylhava J; Hagg S; Pedersen NL; Reynolds CA; Dahl Aslan AK
Article: EUROPEAN JOURNAL OF NUTRITION. 2020;59(4):1763-1766
Polyunsaturated fatty acids and risk of Alzheimer's disease: a Mendelian randomization study
Tomata Y; Larsson SC; Hagg S
Article: BIOLOGICAL PSYCHIATRY. 2020;87(8):708-716
Childhood Adoption and Mental Health in Adulthood: The Role of Gene-Environment Correlations and Interactions in the UK Biobank
Lehto K; Hagg S; Lu D; Karlsson R; Pedersen NL; Mosing MA
Article: CLINICAL EPIGENETICS. 2020;12(1):49
DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936
Seeboth A; McCartney DL; Wang Y; Hillary RF; Stevenson AJ; Walker RM; Campbell A; Evans KL; McIntosh AM; Hagg S; Deary IJ; Marioni RE
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2020;106(3):389-404
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
Li C; Stoma S; Lotta LA; Warner S; Albrecht E; Allione A; Arp PP; Broer L; Buxton JL; Alves ADSC; Deelen J; Fedko IO; Gordon SD; Jiang T; Karlsson R; Kerrison N; Loe TK; Mangino M; Milaneschi Y; Miraglio B; Pervjakova N; Russo A; Surakka I; van der Spek A; Verhoeven JE; Amin N; Beekman M; Blakemore AI; Canzian F; Hamby SE; Hottenga J-J; Jones PD; Jousilahti P; Magi R; Medland SE; Montgomery GW; Nyholt DR; Perola M; Pietilainen KH; Salomaa V; Sillanpaa E; Suchiman HE; van Heemst D; Willemsen G; Agudo A; Boeing H; Boomsma DI; Chirlaque M-D; Fagherazzi G; Ferrari P; Franks P; Gieger C; Eriksson JG; Gunter M; Hagg S; Hovatta I; Imaz L; Kaprio J; Kaaks R; Key T; Krogh V; Martin NG; Melander O; Metspalu A; Moreno C; Onland-Moret NC; Nilsson P; Ong KK; Overvad K; Palli D; Panico S; Pedersen NL; Penninx BWJH; Ramon Quiros J; Riitta Jarvelin M; Rodriguez-Barranco M; Scott RA; Severi G; Slagboom PE; Spector TD; Tjonneland A; Trichopoulou A; Tumino R; Uitterlinden AG; van der Schouw YT; van Duijn CM; Weiderpass E; Denchi EL; Matullo G; Butterworth AS; Danesh J; Samani NJ; Wareham NJ; Nelson CP; Langenberg C; Codd V
Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2020;46(3):316-320
Should we invest in biological age predictors to treat colorectal cancer in older adults?
Hagg S; Jylhava J
Article: ELIFE. 2020;9:e51507
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up
Li X; Ploner A; Wang Y; Magnusson PK; Reynolds C; Finkel D; Pedersen NL; Jylhava J; Hagg S
Article: HEART. 2020;106(4):267-272
Marital status, telomere length and cardiovascular disease risk in a Swedish prospective cohort
Chen R; Zhan Y; Pedersen N; Fall K; Valdimarsdottir UA; Hagg S; Fang F
Article: CLINICAL EPIGENETICS. 2019;11(1):187
Comprehensive longitudinal study of epigenetic mutations in aging
Wang Y; Karlsson R; Jylhava J; Hedman AK; Almqvist C; Karlsson IK; Pedersen NL; Almgren M; Hagg S
Journal article: INNOVATION IN AGING. 2019;3(Supplement_1):s33
LONGITUDINAL TRAJECTORIES OF EPIGENETIC CLOCKS IN HUMANS AND EFFECTS OF MEDICATION USE
Hagg S
Journal article: INNOVATION IN AGING. 2019;3(Supplement_1):s32-s33
DNA METHYLATION: CAUSE OR CONSEQUENCE OF AGING?
Levine ME; Hagg S
Article: PSYCHOSOMATIC MEDICINE. 2019;81(9):799-807
Neuroticism as a Predictor of Frailty in Old Age: A Genetically Informative Approach
Danielsdottir HB; Jylhava J; Hagg S; Lu Y; Colodro-Conde L; Martin NG; Pedersen NL; Mosing MA; Lehto K
Article: EPIGENETICS. 2019;14(10):961-976
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
Sturm G; Cardenas A; Bind M-A; Horvath S; Wang S; Wang Y; Hagg S; Hirano M; Picard M
Article: EMERGING TOPICS IN LIFE SCIENCES. 2019;3(4):411-421
Developments in molecular epidemiology of aging
Hagg S; Belsky DW; Cohen AA
Article: BMJ OPEN. 2019;9(7):e026192
Short-term and long-term case-fatality rates for myocardial infarction and ischaemic stroke by socioeconomic position and sex: a population-based cohort study in Sweden, 1990-1994 and 2005-2009
Malki N; Hagg S; Tiikkaja S; Koupil I; Sparen P; Ploner A
Article: EBIOMEDICINE. 2019;45:487-494
Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobank
Wang Q; Wang Y; Lehto K; Pedersen NL; Williams DM; Hagg S
Article: ROYAL SOCIETY OPEN SCIENCE. 2019;6(6):190420
Smoking does not accelerate leucocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts
Bateson M; Aviv A; Bendix L; Benetos A; Ben-Shlomo Y; Bojesen SE; Cooper C; Cooper R; Deary IJ; Hagg S; Harris SE; Kark JD; Kronenberg F; Kuh D; Labat C; Martin-Ruiz CM; Meyer C; Nordestgaard BG; Penninx BWJH; Pepper GV; Revesz D; Said MA; Starr JM; Syddall H; Thomson WM; van der Harst P; Whooley M; von Zglinicki T; Willeit P; Zhan Y; Nettle D
Article: BIOGERONTOLOGY. 2019;20(3):321-329
Can markers of biological age predict dependency in old age?
Jylhava J; Jiang M; Foebel AD; Pedersen NL; Hagg S
Article: BMC MEDICINE. 2019;17(1):94
The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study
Li X; Ploner A; Karlsson IK; Liu X; Magnusson PKE; Pedersen NL; Haegg S; Jylhava J
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(4):582-587
A Frailty Index for UK Biobank Participants
Williams DM; Jylhava J; Pedersen NL; Hagg S
Article: NATURE GENETICS. 2019;51(3):404-413
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Jansen IE; Savage JE; Watanabe K; Bryois J; Williams DM; Steinberg S; Sealock J; Karlsson IK; Hagg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl IS; Andersen F; Bergh S; Bettella F; Bjornsson S; Braekhus A; Brathen G; de Leeuw C; Desikan RS; Djurovic S; Dumitrescu L; Fladby T; Hohman TJ; Jonsson PV; Kiddle SJ; Rongve A; Saltvedt I; Sando SB; Selbaek G; Shoai M; Skene NG; Snaedal J; Stordal E; Ulstein ID; Wang Y; White LR; Hardy J; Hjerling-Leffler J; Sullivan PF; van der Flier WM; Dobson R; Davis LK; Stefansson H; Stefansson K; Pedersen NL; Ripke S; Andreassen OA; Posthuma D
Article: EBIOMEDICINE. 2019;40:710-716
Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts
Jylhava J; Hjelmborg J; Soerensen M; Munoz E; Tan Q; Kuja-Halkola R; Mengel-From J; Christensen K; Christiansen L; Hagg S; Pedersen NL; Reynolds CA
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2019;109(1):90-98
Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study
Williams DM; Hagg S; Pedersen NL
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(1):57-61
Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data
Marioni RE; Suderman M; Chen BH; Horvath S; Bandinelli S; Morris T; Beck S; Ferrucci L; Pedersen NL; Relton CL; Deary IJ; Hagg S
Article: NATURE COMMUNICATIONS. 2018;9(1):5141
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Franceschini N; Giambartolomei C; de Vries PS; Finan C; Bis JC; Huntley RP; Lovering RC; Tajuddin SM; Winkler TW; Graff M; Kavousi M; Dale C; Smith AV; Hofer E; van Leeuwen EM; Nolte IM; Lu L; Scholz M; Sargurupremraj M; Pitkanen N; Franzen O; Joshi PK; Noordam R; Marioni RE; Hwang S-J; Musani SK; Schminke U; Palmas W; Isaacs A; Correa A; Zonderman AB; Hofman A; Teumer A; Cox AJ; Uitterlinden AG; Wong A; Smit AJ; Newman AB; Britton A; Ruusalepp A; Sennblad B; Hedblad B; Pasaniuc B; Penninx BW; Langefeld CD; Wassel CL; Tzourio C; Fava C; Baldassarre D; O'Leary DH; Teupser D; Kuh D; Tremoli E; Mannarino E; Grossi E; Boerwinkle E; Schadt EE; Ingelsson E; Veglia F; Rivadeneira F; Beutner F; Chauhan G; Heiss G; Snieder H; Campbell H; Voelzke H; Markus HS; Deary IJ; Jukema JW; de Graaf J; Price J; Pott J; Hopewell JC; Liang J; Thiery J; Engmann J; Gertow K; Rice K; Taylor KD; Dhana K; Kiemeney LALM; Lind L; Raffield LM; Launer LJ; Holdt LM; Doer M; Dichgans M; Traylor M; Sitzer M; Kumari M; Kivimaki M; Nalls MA; Melander O; Raitakari O; Franco OH; Rueda-Ochoa OL; Roussos P; Whincup PH; Amouyel P; Giral P; Anugu P; Wong Q; Malik R; Rauramaa R; Burkhardt R; Hardy R; Schmidt R; de Mutsert R; Morris RW; Strawbridge RJ; Wannamethee SG; Hagg S; Shah S; McLachlan S; Trompet S; Seshadri S; Kurl S; Heckbert SR; Ring S; Harris TB; Lehtimaki T; Galesloot TE; Shah T; de Faire U; Plagnol V; Rosamond WD; Post W; Zhu X; Zhang X; Guo X; Saba Y; Dehghan A; Seldenrijk A; Morrison AC; Hamsten A; Psaty BM; van Duijn CM; Lawlor DA; Mook-Kanamori DO; Bowden DW; Schmidt H; Wilson JF; Wilson JG; Rotter JI; Wardlaw JM; Deanfield J; Halcox J; Lyytikainen L-P; Loeffler M; Evans MK; Debette S; Humphries SE; Voelker U; Gudnason V; Hingorani AD; Bjorkegren JLM; Casas JP; O'Donnell CJ
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2018;187(10):2186-2191
Leukocyte Telomere Length and All-Cause Mortality: A Between-Within Twin Study With Time-Dependent Effects Using Generalized Survival Models
Zhan Y; Liu X-R; Reynolds CA; Pedersen NL; Hagg S; Clements MS
Article: EPIGENETICS. 2018;13(9):975-987
Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins
Wang Y; Karlsson R; Lampa E; Zhang Q; Hedman AK; Almgren M; Almqvist C; McRae AF; Marioni RE; Ingelsson E; Visscher PM; Deary IJ; Lind L; Morris T; Beck S; Pedersen NL; Hagg S
Article: NEUROBIOLOGY OF AGING. 2018;69:111-116
Association of telomere length with general cognitive trajectories: a meta-analysis of four prospective cohort studies
Zhan Y; Clements MS; Roberts RO; Vassilaki M; Druliner BR; Boardman LA; Petersen RC; Reynolds CA; Pedersen NL; Hagg S
Article: EPIGENETICS. 2018;13(8):866-874
Implementing a method for studying longitudinal DNA methylation variability in association with age
Wang Y; Pedersen NL; Hagg S
Article: NATURE GENETICS. 2018;50(7):912-919
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Savage JE; Jansen PR; Stringer S; Watanabe K; Bryois J; de Leeuw CA; Nagel M; Awasthi S; Barr PB; Coleman JRI; Grasby KL; Hammerschlag AR; Kaminski JA; Karlsson R; Krapohl E; Lam M; Nygaard M; Reynolds CA; Trampush JW; Young H; Zabaneh D; Hagg S; Hansell NK; Karlsson IK; Linnarsson S; Montgomery GW; Munoz-Manchado AB; Quinlan EB; Schumann G; Skene NG; Webb BT; White T; Arking DE; Avramopoulos D; Bilder RM; Bitsios P; Burdick KE; Cannon TD; Chiba-Falek O; Christoforou A; Cirulli ET; Congdon E; Corvin A; Davies G; Deary IJ; DeRosse P; Dickinson D; Djurovic S; Donohoe G; Conley ED; Eriksson JG; Espeseth T; Freimer NA; Giakoumaki S; Giegling I; Gill M; Glahn DC; Hariri AR; Hatzimanolis A; Keller MC; Knowles E; Koltai D; Konte B; Lahti J; Le Hellard S; Lencz T; Liewald DC; London E; Lundervold AJ; Malhotra AK; Melle I; Morris D; Need AC; Ollier W; Palotie A; Payton A; Pendleton N; Poldrack RA; Raikkonen K; Reinvang I; Roussos P; Rujescu D; Sabb FW; Scult MA; Smeland OB; Smyrnis N; Starr JM; Steen VM; Stefanis NC; Straub RE; Sundet K; Tiemeier H; Voineskos AN; Weinberger DR; Widen E; Yu J; Abecasis G; Andreassen OA; Breen G; Christiansen L; Debrabant B; Dick DM; Heinz A; Hjerling-Leffler J; Ikram MA; Kendler KS; Martin NG; Medland SE; Pedersen NL; Plomin R; Polderman TJC; Ripke S; van der Sluis S; Sullivan PF; Vrieze SI; Wright MJ; Posthuma D
Journal article: REVUE D'EPIDEMIOLOGIE ET DE SANTE PUBLIQUE. 2018;66:s237
Circulating antioxidants and Alzheimer's disease prevention: A Mendelian randomization study
Williams D; Hägg S; Pedersen N
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2018;47(3):899-907
Apolipoprotein E DNA methylation and late-life disease
Karlsson IK; Ploner A; Wang Y; Gatz M; Pedersen NL; Hagg S
Article: NATURE COMMUNICATIONS. 2018;9(1):2098
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
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Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818
A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia
Chen X; Gustafsson S; Whitington T; Borne Y; Lorentzen E; Sun J; Almgren P; Su J; Karlsson R; Song J; Lu Y; Zhan Y; Hagg S; Svensson P; Smedby KE; Slager SL; Ingelsson E; Lindgren CM; Morris AP; Melander O; Karlsson T; de Faire U; Caidahl K; Engstrom G; Lind L; Karlsson MCI; Pedersen NL; Frostegard J; Magnusson PKE
Article: SCIENTIFIC REPORTS. 2018;8(1):7526
Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
Zhou A; Taylor AE; Karhunen V; Zhan Y; Rovio SP; Lahti J; Sjogren P; Byberg L; Lyall DM; Auvinen J; Lehtimaki T; Kahonen M; Hutri-Kahonen N; Perala MM; Michaelsson K; Mahajan A; Lind L; Power C; Eriksson JG; Raitakari OT; Hagg S; Pedersen NL; Veijola J; Jarvelin M-R; Munafo MR; Ingelsson E; Llewellyn DJ; Hypponen E
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2018;7(9):e007806
Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits
Chen X; Kuja-Halkola R; Chang Z; Karlsson R; Hagg S; Svensson P; Pedersen NL; Magnusson PKE
Article: GENES. 2018;9(2):E78-78
DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins
Svane AM; Soerensen M; Lund J; Tan Q; Jylhava J; Wang Y; Pedersen NL; Hagg S; Debrabant B; Deary IJ; Christensen K; Christiansen L; Hjelmborg JB
Article: NEUROLOGY. 2018;90(4):e291-e297
Circulating insulin-like growth factors and Alzheimer disease A mendelian randomization study
Williams DM; Karlsson IK; Pedersen NL; Hagg S
Article: METHODS IN MOLECULAR BIOLOGY. 2018;1750:293-306
Telomere Length Shortening in Alzheimer's Disease: Procedures for a Causal Investigation Using Single Nucleotide Polymorphisms in a Mendelian Randomization Study.
Zhan Y; Hägg S
Article: AGING. 2017;9(12):2629-2646
Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort
Jiang M; Foebel AD; Kuja-Halkola R; Karlsson I; Pedersen NL; Hagg S; Jylhava J
Journal article: F1000RESEARCH. 2017;6:2145
Positive bias for European men in peer reviewed applications for faculty position at Karolinska Institutet
Holst S; Hägg S
Article: MOLECULAR PSYCHIATRY. 2017;22(12):1680-1690
An epigenome-wide association study meta-analysis of educational attainment
Linner RK; Marioni RE; Rietveld CA; Simpkin AJ; Davies NM; Watanabe K; Armstrong NJ; Auro K; Baumbach C; Bonder MJ; Buchwald J; Fiorito G; Ismail K; Iurato S; Joensuu A; Karell P; Kasela S; Lahti J; Mcrae AF; Mandaviya PR; Seppala I; Wang Y; Baglietto L; Binder EB; Harris SE; Hodge AM; Horvath S; Hurme M; Johannesson M; Latvala A; Mather KA; Medland SE; Metspalu A; Milani L; Milne RL; Pattie A; Pedersen NL; Peters A; Polidoro S; Raikkonen K; Severi G; Starr JM; Stolk L; Waldenberger M; Eriksson JG; Esko T; Franke L; Gieger C; Giles GG; Hagg S; Jousilahti P; Kaprio J; Kahonen M; Lehtimaki T; Martin NG; van Meurs JBC; Ollikainen M; Perola M; Posthuma D; Raitakari OT; Sachdev PS; Taskesen E; Uitterlinden AG; Vineis P; Wijmenga C; Wright MJ; Relton C; Smith GD; Deary IJ; Koellinger PD; Benjamin DJ
Article: SCIENTIFIC REPORTS. 2017;7(1):13230
Vitamin D and cognitive function: A Mendelian randomisation study
Maddock J; Zhou A; Cavadino A; Kuzma E; Bao Y; Smart MC; Saum K-U; Schoettker B; Engmann J; Kjaergaard M; Karhunen V; Zhan Y; Lehtimaki T; Rovio SP; Byberg L; Lahti J; Marques-Vidal P; Sen A; Perna L; Schirmer H; Singh-Manoux A; Auvinen J; Hutri-Kahonen N; Kahonen M; Kilander L; Raikkonen K; Melhus H; Ingelsson E; Guessous I; Petrovic KE; Schmidt H; Schmidt R; Vollenweider P; Lind L; Eriksson JG; Michaelsson K; Raitakari OT; Hagg S; Pedersen NL; Herzig K-H; Jarvelin M-R; Veijola J; Kivimaki M; Jorde R; Brenner H; Kumari M; Power C; Llewellyn DJ; Hypponen E
Article: CIRCULATION RESEARCH. 2017;121(3):214-219
Exploring the Causal Pathway From Telomere Length to Coronary Heart Disease A Network Mendelian Randomization Study
Zhan Y; Karlsson IK; Karlsson R; Tillander A; Reynolds CA; Pedersen NL; Hagg S
Journal article: INNOVATION IN AGING. 2017;1(suppl_1):1333-1334
IS ALZHEIMER’S DISEASE INFLUENCED BY INSULIN-LIKE GROWTH FACTORS? A MENDELIAN RANDOMIZATION STUDY
Williams D; Hägg S; Karlsson I; Pedersen NL
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(5):e1142
Genetic susceptibility to cardiovascular disease and risk of dementia
Karlsson IK; Ploner A; Song C; Gatz M; Pedersen NL; Hagg S
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1100
Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
Hagg S; Zhan Y; Karlsson R; Gerritsen L; Ploner A; van der Lee SJ; Broer L; Deelen J; Marioni RE; Wong A; Lundquist A; Zhu G; Hansell NK; Sillanpaa E; Fedko IO; Amin NA; Beekman M; de Craen AJM; Degerman S; Harris SE; Kan K-J; Martin-Ruiz CM; Montgomery GW; Adolfsson AN; Reynolds CA; Samani NJ; Suchiman HED; Viljanen A; von Zglinicki T; Wright MJ; Hottenga J-J; Boomsma DI; Rantanen T; Kaprio JA; Nyholt DR; Martin NG; Nyberg L; Adolfsson R; Kuh D; Starr JM; Deary IJ; Slagboom PE; van Duijn CM; Codd V; Pedersen NL
Article: F1000RESEARCH. 2017;6:2145
Positive bias for European men in peer reviewed applications for faculty position at Karolinska Institutet.
Holst S; Hägg S
Article: AGING. 2016;8(7):1398-1415
Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk
Berglund K; Reynolds CA; Ploner A; Gerritsen L; Hovatta I; Pedersen NL; Hagg S
Article: METABOLOMICS. 2016;12(1):4
Large-scale non-targeted metabolomic profiling in three human population-based studies
Ganna A; Fall T; Salihovic S; Lee W; Broeckling CD; Kumar J; Hagg S; Stenemo M; Magnusson PKE; Prenni JE; Lind L; Pawitan Y; Ingelsson E
Article: HUMAN MOLECULAR GENETICS. 2015;24(23):6849-6860
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity
Hagg S; Ganna A; Van der Laan SW; Esko T; Pers TH; Locke AE; Berndt SI; Justice AE; Kahali B; Siemelink MA; Pasterkamp G; Strachan DP; Speliotes EK; North KE; Loos RJF; Hirschhorn JN; Pawitan Y; Ingelsson E
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2015;97(5):708-714
Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models
Chen X; Kuja-Halkola R; Rahman I; Arpegard J; Viktorin A; Karlsson R; Hagg S; Svensson P; Pedersen NL; Magnusson PKE
Article: PLOS GENETICS. 2015;11(7):e1005230
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
Horikoshi M; Maegi R; van de Bunt M; Surakka I; Sarin A-P; Mahajan A; Marullo L; Thorleifsson G; Haegg S; Hottenga J-J; Ladenvall C; Ried JS; Winkler TW; Willems SM; Pervjakova N; Esko T; Beekman M; Nelson CP; Willenborg C; Wiltshire S; Ferreira T; Fernandez J; Gaulton KJ; Steinthorsdottir V; Hamsten A; Magnusson PKE; Willemsen G; Milaneschi Y; Robertson NR; Groves CJ; Bennett AJ; Lehtimaeki T; Viikari JS; Rung J; Lyssenko V; Perola M; Heid IM; Herder C; Grallert H; Mueller-Nurasyid M; Roden M; Hypponen E; Isaacs A; van Leeuwen EM; Karssen LC; Mihailov E; Houwing-Duistermaat JJ; de Craen AJM; Deelen J; Havulinna AS; Blades M; Hengstenberg C; Erdmann J; Schunkert H; Kaprio J; Tobin MD; Samani NJ; Lind L; Salomaa V; Lindgren CM; Slagboom PE; Metspalu A; van Duijn CM; Eriksson JG; Peters A; Gieger C; Jula A; Groop L; Raitakari OT; Power C; Penninx BWJH; de Geus E; Smit JH; Boomsma DI; Pedersen NL; Ingelsson E; Thorsteinsdottir U; Stefansson K; Ripatti S; Prokopenko I; McCarthy MI; Morris AP
Article: MOLECULAR PSYCHIATRY. 2015;20(6):735-743
The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼ 25 000 subjects
Peyrot WJ; Lee SH; Milaneschi Y; Abdellaoui A; Byrne EM; Esko T; de Geus EJC; Hemani G; Hottenga JJ; Kloiber S; Levinson DF; Lucae S; Martin NG; Medland SE; Metspalu A; Milani L; Noethen MM; Potash JB; Rietschel M; Rietveld CA; Ripke S; Shi J; Willemsen G; Zhu Z; Boomsma DI; Wray NR; Penninx BWJH
Article: NATURE GENETICS. 2015;47(6):589-597
The impact of low-frequency and rare variants on lipid levels
Surakka I; Horikoshi M; Magi R; Sarin A-P; Mahajan A; Lagou V; Marullo L; Ferreira T; Miraglio B; Timonen S; Kettunen J; Pirinen M; Karjalainen J; Thorleifsson G; Hagg S; Hottenga J-J; Isaacs A; Ladenvall C; Beekman M; Esko T; Ried JS; Nelson CP; Willenborg C; Gustafsson S; Westra H-J; Blades M; de Craen AJM; de Geus EJ; Deelen J; Grallert H; Hamsten A; Havulinna AS; Hengstenberg C; Houwing-Duistermaat JJ; Hypponen E; Karssen LC; Lehtimaki T; Lyssenko V; Magnusson PKE; Mihailov E; Muller-Nurasyid M; Mpindi J-P; Pedersen NL; Penninx BWJH; Perola M; Pers TH; Peters A; Rung J; Smit JH; Steinthorsdottir V; Tobin MD; Tsernikova N; van Leeuwen EM; Viikari JS; Willems SM; Willemsen G; Schunkert H; Erdmann J; Samani NJ; Kaprio J; Lind L; Gieger C; Metspalu A; Slagboom PE; Groop L; van Duijn CM; Eriksson JG; Jula A; Salomaa V; Boomsma DI; Power C; Raitakari OT; Ingelsson E; Jarvelin M-R; Thorsteinsdottir U; Franke L; Ikonen E; Kallioniemi O; Pietiainen V; Lindgren CM; Stefansson K; Palotie A; McCarthy MI; Morris AP; Prokopenko I; Ripatti S
Article: DIABETES. 2015;64(5):1841-1852
Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors
Fall T; Hagg S; Ploner A; Maegi R; Fischer K; Draisma HHM; Sarin A-P; Benyamin B; Ladenvall C; Akerlund M; Kals M; Esko T; Nelson CP; Kaakinen M; Huikari V; Mangino M; Meirhaeghe A; Kristiansson K; Nuotio M-L; Kobl M; Grallert H; Dehghan A; Kuningas M; de Vries PS; de Bruijn RFAG; Willems SM; Heikkila K; Silventoinen K; Pietilainen KH; Legry V; Giedraitis V; Goumidi L; Syvanen A-C; Strauch K; Koenig W; Lichtner P; Herder C; Palotie A; Menni C; Uitterlinden AG; Kuulasmaa K; Havulinna AS; Moreno LA; Gonzalez-Gross M; Evans A; Tregouet D-A; Yarnell JWG; Virtamo J; Ferrieres J; Veronesi G; Perola M; Arveiler D; Brambilla P; Lind L; Kaprio J; Hofman A; Stricker BH; van Duijn CM; Ikram MA; Franco OH; Cottel D; Dallongeville J; Hall AS; Jula A; Tobin MD; Penninx BW; Peters A; Gieger C; Samani NJ; Montgomery GW; Whiteld JB; Martin NG; Groop L; Spector TD; Magnusson PK; Amouyel P; Boomsma DI; Nilsson PM; Jarvelin M-R; Lyssenko V; Metspalu A; Strachan DP; Salomaa V; Ripatti S; Pedersen NL; Prokopenko I; McCarthy MI; Ingelsson E
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2015;44(2):578-586
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Haegg S; Fall T; Ploner A; Maegi R; Fischer K; Draisma HHM; Kals M; de Vries PS; Dehghan A; Willems SM; Sarin A-P; Kristiansson K; Nuotio M-L; Havulinna AS; de Bruijn RFAG; Ikram MA; Kuningas M; Stricker BH; Franco OH; Benyamin B; Gieger C; Hall AS; Huikari V; Jula A; Jarvelin M-R; Kaakinen M; Kaprio J; Kobl M; Mangino M; Nelson CP; Palotie A; Samani NJ; Spector TD; Strachan DP; Tobin MD; Whitfield JB; Uitterlinden AG; Salomaa V; Syvanen A-C; Kuulasmaa K; Magnusson PK; Esko T; Hofman A; de Geus EJC; Lind L; Giedraitis V; Perola M; Evans A; Ferrieres J; Virtamo J; Kee F; Tregouet D-A; Arveiler D; Amouyel P; Gianfagna F; Brambilla P; Ripatti S; van Duijn CM; Metspalu A; Prokopenko I; McCarthy MI; Pedersen NL; Ingelsson E
Journal article: AMERICAN JOURNAL OF MEDICAL GENETICS, PART B: NEUROPSYCHIATRIC GENETICS. 2014;165(6):510-520
Polygenic Scores Associated With Educational Attainment in Adults Predict Educational Achievement and ADHD Symptoms in Children
de Zeeuw EL; van Beijsterveldt CEM; Glasner TJ; Bartels M; Ehli EA; Davies GE; Hudziak JJ; Rietveld CA; Groen-Blokhuis MM; Hottenga JJ; de Geus EJC; Boomsma DI
Article: DIABETIC MEDICINE. 2014;31(7):787-793
Serum selenium in relation to measures of glucose metabolism and incidence of Type 2 diabetes in an older Swedish population
Gao H; Hagg S; Sjogren P; Lambert PC; Ingelsson E; van Dam RM
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2014;43(3):878-886
Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers
Deelen J; Beekman M; Codd V; Trompet S; Broer L; Hagg S; Fischer K; Thijssen PE; Suchiman HED; Postmus I; Uitterlinden AG; Hofman A; de Craen AJM; Metspalu A; Pedersen NL; van Duijn CM; Jukema JW; Houwing-Duistermaat JJ; Samani NJ; Slagboom PE
Article: HUMAN MOLECULAR GENETICS. 2014;23(9):2490-2497
DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
Perry JRB; Hsu Y-H; Chasman DI; Johnson AD; Elks C; Albrecht E; Andrulis IL; Beesley J; Berenson GS; Bergmann S; Bojesen SE; Bolla MK; Brown J; Buring JE; Campbell H; Chang-Claude J; Chenevix-Trench G; Corre T; Couch FJ; Cox A; Czene K; D'adamo AP; Davies G; Deary IJ; Dennis J; Easton DF; Engelhardt EG; Eriksson JG; Esko T; Fasching PA; Figueroa JD; Flyger H; Fraser A; Garcia-Closas M; Gasparini P; Gieger C; Giles G; Guenel P; Haegg S; Hall P; Hayward C; Hopper J; Ingelsson E; Kardia LR; Kasiman K; Knight JA; Lahti J; Lawlor DA; Magnusson PKE; Margolin S; Marsh JA; Metspalu A; Olson JE; Pennell CE; Polasek O; Rahman I; Ridker PM; Robino A; Rudan I; Rudolph A; Salumets A; Schmidt MK; Schoemaker MJ; Smith EN; Smith JA; Southey M; Stoeckl D; Swerdlow AJ; Thompson DJ; Truong T; Ulivi S; Waldenberger M; Wang Q; Wild S; Wilson JF; Wright AF; Zgaga L; Ong KK; Murabito JM; Karasik D; Murray A
Article: EUROPEAN RESPIRATORY JOURNAL. 2014;43(4):983-992
Telomere length in circulating leukocytes is associated with lung function and disease
Albrecht E; Sillanpaa E; Karrasch S; Alves AC; Codd V; Hovatta I; Buxton JL; Nelson CP; Broer L; Hagg S; Mangino M; Willemsen G; Surakka I; Ferreira MAR; Amin N; Oostra BA; Backmand HM; Peltonen M; Sarna S; Rantanen T; Sipila S; Korhonen T; Madden PAF; Gieger C; Jorres RA; Heinrich J; Behr J; Huber RM; Peters A; Strauch K; Wichmann HE; Waldenberger M; Blakemore AIF; de Geus EJC; Nyholt DR; Henders AK; Piirila PL; Rissanen A; Magnusson PKE; Vinuela A; Pietilainen KH; Martin NG; Pedersen NL; Boomsma DI; Spector TD; van Duijn CM; Kaprio J; Samani NJ; Jarvelin M-R; Schulz H
Article: PLOS GENETICS. 2014;10(2):e1004201
Plasma Cholesterol-Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis
Bjorkegren JLM; Hagg S; Talukdar HA; Asl HF; Jain RK; Cedergren C; Shang M-M; Rossignoli A; Takolander R; Melander O; Hamsten A; Michoel T; Skogsberg J
Article: CELL CYCLE. 2014;13(23):3645-3658
Inactivation of the budding yeast cohesin loader Scc2 alters gene expression both globally and in response to a single DNA double strand break
Lindgren E; Hagg S; Giordano F; Bjorkegren J; Strom L
Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2013;23(suppl_1):ckt126.355
Temporal trends in case-fatality of myocardial infarction and stroke by socioeconomic position in Sweden 1987-2010
Malki N; Plone A; Koupil I; Hägg S; Tiikkaja S; Lambert P; Sparen P
Article: SCIENCE. 2013;340(6139):1467-1471
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Rietveld CA; Medland SE; Derringer J; Yang J; Esko T; Martin NW; Westra H-J; Shakhbazov K; Abdellaoui A; Agrawal A; Albrecht E; Alizadeh BZ; Amin N; Bamard J; Baumeister SE; Benke KS; Bielak LF; Boatman JA; Boyle PA; Davies G; De Leeuw C; Eklund N; Evans DS; Ferhmann R; Fischer K; Gieger C; Gjessing HK; Haegg S; Harris JR; Hayward C; Holzapfel C; Ibrahim-Verbaas CA; Ingelsson E; Jacobsson B; Joshi PK; Jugessur A; Kaakinen M; Kanoni S; Karjalainen J; Kolcic I; Kristiansson K; Kutalik Z; Lahti J; Lee SH; Lin P; Lind PA; Liu Y; Lohman K; Loitfelder M; McMahon G; Vidal PM; Meirelles O; Milani L; Myhre R; Nuotio M-L; Oldmeadow CJ; Petrovic KE; Peyrot WJ; Polasek O; Quaye L; Reinmaa E; Rice JP; Rizzi TS; Schmidt H; Schmidt R; Smith AV; Smith JA; Tanaka T; Terracciano A; van der Loos MJHM; Vitart V; Voelzke H; Wellmann J; Yu L; Zhao W; Allik J; Attia JR; Bandinelli S; Bastardot F; Beauchamp J; Bennett DA; Berger K; Bierut LJ; Boomsma DI; Bueltmann U; Campbell H; Chabris CF; Cherkas L; Chung MK; Cucca F; de Andrade M; De Jager PL; De Neve J-E; Deary IJ; Dedoussis GV; Deloukas P; Dimitriou M; Eiriksdottir G; Elderson MF; Eriksson JG; Evans DM; Faul JD; Ferrucci L; Garcia ME; Groenberg H; Guonason V; Hall P; Harris JM; Harris TB; Hastie ND; Heath AC; Hernandez DG; Hoffmann W; Hofman A; Holle R; Holliday EG; Hottenga J-J; Iacono WG; Illig T; Jaervelin M-R; Kaehoenen M; Kaprio J; Kirkpatrick RM; Kowgier M; Latvala A; Launer LJ; Lawlor DA; Lehtimaeki T; Li J; Lichtenstein P; Lichtner P; Liewald DC; Madden PA; Magnusson PKE; Maekinen TE; Masala M; McGue M; Metspalu A; Mielck A; Miller MB; Montgomery GW; Mukherjee S; Nyholt DR; Oostra BA; Palmer LJ; Palotie A; Penninx BWJH; Perola M; Peyser PA; Preisig M; Raeikkoenen K; Raitakari OT; Realo A; Ring SM; Ripatti S; Rivadeneira F; Rudan I; Rustichini A; Salomaa V; Sarin A-P; Schlessinger D; Scott RJ; Snieder H; St Pourcain B; Starr JM; Sul JH; Surakka I; Svento R; Teumer A; Tiemeier H; van Rooij FJA; Van Wagoner DR; Vartiainen E; Viikari J; Vollenweider P; Vonk JM; Waeber G; Weir DR; Wichmann H-E; Widen E; Willemsen G; Wilson JF; Wright AF; Conley D; Davey-Smith G; Franke L; Groenen PJF; Hofman A; Johannesson M; Kardia SLR; Krueger RF; Laibson D; Martin NG; Meyer MN; Posthuma D; Thurik AR; Timpson NJ; Uitterlinden AG; van Duijn CM; Visscher PM; Benjamin DJ; Cesarini D; Koellinger PD
Article: ACTA PHYSIOLOGICA. 2013;208(1):88-94
Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population
Lind L; Syvanen A-C; Axelsson T; Lundmark P; Hagg S; Larsson A
Article: DIABETES. 2013;62(4):1338-1344
Evidence of a Causal Relationship Between Adiponectin Levels and Insulin Sensitivity
Gao H; Fall T; van Dam RM; Flyvbjerg A; Zethelius B; Ingelsson E; Hagg S
Article: NATURE GENETICS. 2013;45(4):422-427e2
Identification of seven loci affecting mean telomere length and their association with disease
Codd V; Nelson CP; Albrecht E; Mangino M; Deelen J; Buxton JL; Hottenga JJ; Fischer K; Esko T; Surakka I; Broer L; Nyholt DR; Leach IM; Salo P; Hagg S; Matthews MK; Palmen J; Norata GD; O'Reilly PF; Saleheen D; Amin N; Balmforth AJ; Beekman M; de Boer RA; Bohringer S; Braund PS; Burton PR; de Craen AJM; Denniff M; Dong Y; Douroudis K; Dubinina E; Eriksson JG; Garlaschelli K; Guo D; Hartikainen A-L; Henders AK; Houwing-Duistermaat JJ; Kananen L; Karssen LC; Kettunen J; Klopp N; Lagou V; van Leeuwen EM; Madden PA; Maegi R; Magnusson PKE; Mannisto S; McCarthy MI; Medland SE; Mihailov E; Montgomery GW; Oostra BA; Palotie A; Peters A; Pollard H; Pouta A; Prokopenko I; Ripatti S; Salomaa V; Suchiman HED; Valdes AM; Verweij N; Vinuela A; Wang X; Wichmann H-E; Widen E; Willemsen G; Wright MJ; Xia K; Xiao X; van Veldhuisen DJ; Catapano AL; Tobin MD; Hall AS; Blakemore AIF; van Gilst WH; Zhu H; Erdmann J; Reilly MP; Kathiresan S; Schunkert H; Talmud PJ; Pedersen NL; Perola M; Ouwehand W; Kaprio J; Martin NG; van Duijn CM; Hovatta I; Gieger C; Metspalu A; Boomsma DI; Jarvelin M-R; Slagboom PE; Thompson JR; Spector TD; van der Harst P; Samani NJ
Article: PLOS MEDICINE. 2013;10(6):e1001474
The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Fall T; Hagg S; Maegi R; Ploner A; Fischer K; Horikoshi M; Sarin A-P; Thorleifsson G; Ladenvall C; Kals M; Kuningas M; Draisma HHM; Ried JS; van Zuydam NR; Huikari V; Mangino M; Sonestedt E; Benyamin B; Nelson CP; Rivera NV; Kristiansson K; Shen H-Y; Havulinna AS; Dehghan A; Donnelly LA; Kaakinen M; Nuotio M-L; Robertson N; de Bruijn RFAG; Ikram MA; Amin N; Balmforth AJ; Braund PS; Doney ASF; Doering A; Elliott P; Esko T; Franco OH; Gretarsdottir S; Hartikainen A-L; Heikkila K; Herzig K-H; Holm H; Hottenga JJ; Hypponen E; Illig T; Isaacs A; Isomaa B; Karssen LC; Kettunen J; Koenig W; Kuulasmaa K; Laatikainen T; Laitinen J; Lindgren C; Lyssenko V; Laara E; Rayner NW; Mannisto S; Pouta A; Rathmann W; Rivadeneira F; Ruokonen A; Savolainen MJ; Sijbrands EJG; Small KS; Smit JH; Steinthorsdottir V; Syvanen A-C; Taanila A; Tobin MD; Uitterlinden AG; Willems SM; Willemsen G; Witteman J; Perola M; Evans A; Ferrieres J; Virtamo J; Kee F; Tregouet D-A; Arveiler D; Amouyel P; Ferrario MM; Brambilla P; Hall AS; Heath A; Madden PAF; Martin NG; Montgomery GW; Whitfield JB; Jula A; Knekt P; Oostra B; van Duijn CM; Penninx BWJH; Smith GD; Kaprio J; Samani NJ; Gieger C; Peters A; Wichmann H-E; Boomsma DI; de Geus EJC; Tuomi T; Power C; Hammond CJ; Spector TD; Lind L; Orho-Melander M; Palmer CNA; Morris AD; Groop L; Jarvelin M-R; Salomaa V; Vartiainen E; Hofman A; Ripatti S; Metspalu A; Thorsteinsdottir U; Stefansson K; Pedersen NL; McCarthy MI; Ingelsson E; Prokopenko I
Article: BMC PUBLIC HEALTH. 2012;12:664
Relative deprivation and mortality - a longitudinal study in a Swedish population of 4,7 million, 1990-2006
Yngwe MA; Kondo N; Hagg S; Kawachi I
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2011;27(6):851-857
Blood levels of dual-specificity phosphatase-1 independently predict risk for post-operative morbidities causing prolonged hospitalization after coronary artery bypass grafting
Hagg S; Alserius T; Noori P; Ruusalepp A; Ivert T; Tegner J; Bjorkegren J; Skogsberg J
Journal article: ATHEROSCLEROSIS PLUS. 2011;12(1):64
295 ATHEROSCLEROSIS REGRESSION IN A MOUSE MODEL WITH HUMAN-LIKE HYPERCHOLESTEROLEMIA
Björkegren J; Hägg S; Maleki S; Shang M; Michoel T; Skogsberg J
Article: PLOS ONE. 2011;6(4):e18248
Carotid Plaque Age Is a Feature of Plaque Stability Inversely Related to Levels of Plasma Insulin
Hagg S; Salehpour M; Noori P; Lundstrom J; Possnert G; Takolander R; Konrad P; Rosfors S; Ruusalepp A; Skogsberg J; Tegner J; Bjorkegren J
Article: PLOS GENETICS. 2009;5(12):e1000754
Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) Study
Hagg S; Skogsberg J; Lundstrom J; Noori P; Nilsson R; Zhong H; Maleki S; Shang M-M; Brinne B; Bradshaw M; Bajic VB; Samnegard A; Silveira A; Kaplan LM; Gigante B; Leander K; de Faire U; Rosfors S; Lockowandt U; Liska J; Konrad P; Takolander R; Franco-Cereceda A; Schadt EE; Ivert T; Hamsten A; Tegner J; Bjorkegren J
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Review: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(10):glad251
Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age
Mak JKL; Karlsson IK; Tang B; Wang Y; Pedersen NL; Hagg S; Jylhava J; Reynolds CA
Preprint: MEDRXIV. 2024;MEDRXIV
Causes and consequences of major depressive disorder: An encompassing Mendelian randomization study.
Pasman JA; Bergstedt J; Harder A; Gong T; Xiong Y; Hägg S; Fang F; Treur JL; Choi KW; Sullivan PF; Lu Y
Preprint: BIORXIV. 2024
Biological aging of different blood cell types
Marttila S; Rajić S; Ciantar J; Mak JKL; Junttila I; Kummola L; Hägg S; Raitoharju E; Kananen L
Review: NATURE MEDICINE. 2024;30(3):360-372
Validation of biomarkers of aging
Moqri M; Herzog C; Poganik JR; Ying K; Justice JN; Belsky DW; Higgins-Chen AT; Chen BH; Cohen AA; Fuellen G; Haegg S; Marioni RE; Widschwendter M; Fortney K; Fedichev PO; Zhavoronkov A; Barzilai N; Lasky-Su J; Kiel DP; Kennedy BK; Cummings S; Slagboom PE; Verdin E; Maier AB; Sebastiano V; Snyder MP; Gladyshev VN; Horvath S; Ferrucci L
Letter: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2024;17(1):e004232
Associations Between Genetic Variation in the Targets of Low-Density Lipoprotein-Lowering Drugs and Rheumatoid Arthritis
Qin C; Hagg S
Preprint: MEDRXIV. 2024;MEDRXIV
Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease.
Bergstedt J; Pasman JA; Ma Z; Harder A; Yao S; Parker N; Treur JL; Smit DJA; Frei O; Shadrin A; Meijsen JJ; Shen Q; Hägg S; Tornvall P; Buil A; Werge T; Hjerling-Leffler J; Als TD; Børglum AD; Lewis CM; McIntosh AM; Valdimarsdóttir UA; Andreassen OA; Sullivan PF; Lu Y; Fang F
Preprint: RESEARCH SQUARE. 2023
A Swedish national register study on the association between dementia, walking ability and survival after a hip fracture
Linder PDGB; Religa DD; Gustavsson F; Eriksdotter M; Hedström MK; Hägg SJ
Preprint: MEDRXIV. 2023
Mapping the aetiological foundations of the heart failure spectrum using human genetics
Henry A; Mo X; Finan C; Chaffin M; Speed D; Issa H; Denaxas S; Ware J; Zheng S; Malarstig A; Gratton J; Bond I; Roselli C; Miller D; Chopade S; Schmidt F; Abner E; Adams L; Andersson C; Aragam K; Ärnlöv J; Asselin G; Axelsson Raja A; Backman J; Bartz T; Biddinger K; Biggs M; Bloom H; Boersma E; Brandimarto J; Brown M; Brunak S; Bruun MT; Buckbinder L; Bundgaard H; Carey D; Chasman D; Chen X; Cook J; Czuba T; de Denus S; Dehghan A; Delgado G; Doney A; Dörr M; Dowsett J; Dudley S; Engström G; Erikstrup C; Esko T; Farber-Eger E; Felix S; Finer S; Ford I; Ghanbari M; Ghasemi S; Ghouse J; Giedraitis V; Giulianini F; Gottdiener J; Gross S; Guðbjartsson D; Gui H; Gutmann R; Hägg S; Haggerty C; Hedman Å; Helgadottir A; Hemingway H; Hillege H; Hyde C; Jensen BA; Jukema W; Kardys I; Karra R; Kavousi M; Kizer J; Kleber M; Køber L; Koekemoer A; Kuchenbaecker K; Lai Y-P; Lanfear D; Langenberg C; Lin H; Lind L; Lindgren C; Liu P; London B; Lowery B; Luan J; Lubitz S; Magnusson P; Margulies K; Marston N; Martin H; März W; Melander O; Mordi I; Morley M; Morris A; Morrison A; Morton L; Nagle M; Nelson C; Niessner A; Niiranen T; Noordam R; Nowak C; O’Donoghue M; Ostrowski SR; Owens A; Palmer C; Paré G; Pedersen OB; Perola M; Pigeyre M; Psaty B; Rice K; Ridker P; Romaine S; Rotter J; Ruff C; Sabatine M; Sallah N; Salomaa V; Sattar N; Shalaby A; Shekhar A; Smelser D; Smith N; Sørensen E; Srinivasan S; Stefansson K; Sveinbjörnsson G; Svensson P; Tammesoo M-L; Tardif J-C; Teder-Laving M; Teumer A; Thorgeirsson G; Thorsteinsdottir U; Torp-Pedersen C; Tragante V; Trompet S; Uitterlinden A; Ullum H; van der Harst P; van Heel D; van Setten J; van Vugt M; Veluchamy A; Verschuuren M; Verweij N; Vissing CR; Völker U; Voors A; Wallentin L; Wang Y; Weeke P; Wiggins K; Williams K; Yang Y; Yu B; Zannad F; Zheng C; Genes & Health Research Team; DBDS Genomic Consortium; Asselbergs F; Cappola T; Dubé M-P; Dunn M; Lang C; Samani N; Shah S; Vasan R; Smith G; Holm H; Shah S; Ellinor P; Hingorani A; Wells Q; Lumbers T; HERMES Consortium
Preprint: MEDRXIV. 2023
Deep learning-based prediction of one-year mortality in the entire Finnish population is an accurate but unfair digital marker of aging
Vabalas A; Hartonen T; Vartiainen P; Jukarainen S; Viippola E; Rodosthenous RS; Liu A; Hägg S; Perola M; Ganna A
Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):716
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores (vol 12, 3417, 2021)
de Rojas I; Moreno-Grau S; Tesi N; Grenier-Boley B; Andrade V; Jansen I; Pedersen NL; Stringa N; Zettergren A; Hernandez I; Montrreal L; Antunez C; Antonell A; Tankard RM; Bis J; Sims R; Bellenguez C; Quintela I; Gonzalez-Perez A; Calero M; Franco-Macias E; Macias J; Blesa R; Cervera-Carles L; Menendez-Gonzalez M; Frank-Garcia AC; Royo JLW; Moreno F; Huerto Vilas R; Baquero M; Diez-Fairen M; Lage C; Garcia-Madrona S; Garcia-Gonzalez P; Alarcon-Martin E; Valero S; Sotolongo-Grau O; Ullgren A; Naj AC; Lemstra AW; Benaque A; Perez-Cordon A; Benussi AL; Rabano A; Padovani A; Squassina A; de Mendonca A; Arias Pastor AM; Kok AAL; Meggy A; Pastor AB; Espinosa A; Corma-Gomez A; Martin Montes A; Sanabria A; DeStefano AW; Schneider A; Haapasalo A; Kinhult Stahlbom A; Tybjaerg-Hansen A; Hartmann AM; Spottke A; Corbaton-Anchuelo A; Rongve AB; Borroni B; Arosio B; Nacmias B; Nordestgaard BG; Kunkle BW; Charbonnier C; Abdelnour C; Masullo C; Martinez Rodriguez C; Munoz-Fernandez C; Dufouil C; Graff C; Ferreira C; Chillotti C; Reynolds CA; Fenoglio C; Van Broeckhoven C; Clark C; Pisanu C; Satizabal CL; Holmes C; Buiza-Rueda D; Aarsland D; Rujescu D; Alcolea D; Galimberti D; Wallon D; Seripa D; Grunblatt E; Dardiotis E; Duezel E; Scarpini E; Conti E; Rubino E; Gelpi E; Rodriguez-Rodriguez E; Duron E; Boerwinkle E; Ferri E; Tagliavini F; Kuecuekali F; Pasquier F; Sanchez-Garcia F; Mangialasche F; Jessen F; Nicolas G; Selbaek G; Ortega GK; Chene G; Hadjigeorgiou G; Rossi G; Spalletta G; Giaccone G; Grande G; Binetti G; Papenberg G; Hampel H; Bailly H; Zetterberg H; Soininen H; Karlsson I; Alvarez I; Appollonio I; Giegling I; Skoog I; Saltvedt I; Rainero I; Rosas Allende I; Hort J; Diehl-Schmid J; Van Dongen J; Vidal J-S; Lehtisalo J; Wiltfang J; Thomassen JQ; Kornhuber J; Haines JA; Vogelgsang J; Pineda J; Fortea J; Popp J; Deckert J; Buerger K; Morgan K; Fliessbach K; Sleegers K; Molina-Porcel L; Kilander L; Weinhold L; Farrer L; Wang L-S; Kleineidam L; Farotti LA; Parnetti L; Tremolizzo L; Hausner L; Benussi L; Froelich L; Ikram MA; Deniz-Naranjo MC; Tsolaki M; Rosende-Roca M; Lowenmark M; Hulsman M; Spallazzi M; Pericak-Vance MH; Esiri M; Bernal Sanchez-Arjona M; Dalmasso MC; Martinez-Larrad MTT; Arcaro M; Noethen M; Fernandez-Fuertes M; Dichgans M; Ingelsson M; Herrmann M; Scherer M; Vyhnalek M; Kosmidis MM; Yannakoulia MM; Schmid M; Ewers MJ; Heneka MT; Wagner M; Scamosci M; Kivipelto M; Hiltunen M; Zulaica M; Alegret M; Fornage M; Roberto N; van Schoor N; Seidu N; Banaj N; Armstrong N; Scarmeas N; Scherbaum NA; Goldhardt O; Hanon O; Peters O; Skrobot OA; Quenez O; Lerch O; Bossu P; Caffarra P; Dionigi Rossi P; Sakka P; Mecocci P; Hoffmann P; Holmans P; Fischer PA; Riederer P; Yang Q; Marshall R; Kalaria RN; Mayeux R; Vandenberghe R; Cecchetti R; Ghidoni R; Frikke-Schmidt R; Sorbi S; Haegg S; Engelborghs S; Helisalmi S; Botne Sando S; Kern S; Archetti S; Boschi S; Fostinelli S; Gil S; Mendoza S; Mead S; Ciccone S; Djurovic S; Heilmann-Heimbach S; Riedel-Heller S; Kuulasmaa T; del Ser T; Lebouvier T; Polak T; Ngandu T; Grimmer T; Bessi V; Escott-Price V; Giedraitis V; Deramecourt V; Maier W; Jian X; Pijnenburg YAL; Kehoe PG; Garcia-Ribas G; Sanchez-Juan P; Pastor P; Perez-Tur J; Pinol-Ripoll G; De Munain AL; Garcia-Alberca JM; Bullido MJ; Alvarez V; Lleo A; Real LM; Medina PMM; Scheltens P; Holstege H; Marquie M; Saez ME; Carracedo A; Amouyel P; Schellenberg GD; Williams J; Seshadri S; Van Duijn C; Mather KA; Sanchez-Valle R; Serrano-Rios M; Orellana A; Tarraga L; Blennow K; Andreassen OA; Posthuma D; Clarimon J; Boada M; Van der Flier WM; Ramirez A; Lambert J-C; Van der Lee SJ; Ruiz A
Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2023;79:25
The importance of nutrition for dementia and frailty: Evidence from epidemiological studies in aging
Hagg S
Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:311-312
Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study
Qin C; Diaz-Gallo LM; Tang B; Wang Y; Padyukov L; Askling J; Hagg S
Conference publication: INNOVATION IN AGING. 2022;6:243
FUNCTIONAL AGING TRAJECTORIES AND DRUG INTERACTIONS
Deliveira TL; Hagg S
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:E50
GENETIC EPIDEMIOLOGY AND POLYGENICITY OF PSYCHOTIC MAJOR DEPRESSIVE DISORDER
Thi TDN; Kuja-Halkola R; Kowalec K; Harder A; Xiong Y; Landen M; Hagg S; Lichtenstein P; Larsson H; Buil A; Meijsen J; Sullivan P; Dalman C; Pasman J; Lu Y
Editorial comment: NATURE MICROBIOLOGY. 2022;7(8):1106-1107
COVID vaccination in older adults
Hagg S; Religa D
Preprint: BIORXIV. 2022
Methylation status of VTRNA2-1/nc886 is stable across human populations, monozygotic twin pairs and in majority of somatic tissues
Marttila S; Tamminen H; Rajić S; Mishra P; Lehtimäki T; Raitakari O; Kähönen M; Kananen L; Jylhävä J; Hägg S; Delerue T; Peters A; Waldenberger M; Kleber M; März W; Luoto R; Raitanen J; Sillanpää E; Laakkonen E; Heikkinen A; Ollikainen M; Raitoharju E
Preprint: RESEARCH SQUARE. 2022
Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells
Karlsson I; Ploner A; Wang Y; Gatz M; Pedersen N; Hägg S
Preprint: MEDRXIV. 2022
Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels
Karlsson I; Zhan Y; Wang Y; Li X; Jylhava J; Hagg S; Dahl Aslan A; Gatz M; Pedersen N; Reynolds C
Letter: CLINICAL NUTRITION. 2022;41(2):573-574
Response to Letter to the Editor: Comment on "Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19" (by Cafe Balci, MD, Hacettepe University Faculty of Medicine Department of Internal Medicine Division of Geriatric Medicine)
Kananen L; Religa D; Eriksdotter M; Hagg S; Julhava J; Cederholm T
Editorial comment: NATURE AGING. 2022;2(2):102-104
Telomere research entering the big data era
Hagg S; Zhan Y
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:146
Dementia and antipsychotics are associated with significantly higher mortality in patients with COVID-19
Secnik J; Eriksdotter M; Rytarowski A; Annetorp M; Johnell K; Hagg S; Religa D
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:1207-1209
Occupational Inhaled Agents Constitute Major Risk Factors for Rheumatoid Arthritis, Particularly in the Context of Genetic Predisposition and Smoking
Tang B; Liu Q; Ilar A; Wiebert P; Hagg S; Padyukov L; Klareskog L; Alfredsson L; Jiang X
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):212
Polygenicity of comorbid depression in multiple sclerosis
Kowalec K; Salter A; Fitzgerald KC; Harder A; Lu Y; Dolovich C; Hagg S; Hitchon C; Bernstein CN; Cutter G; Marriott JJ; Bolton JM; McKay K; Graff LA; Patten S; Marrie RA
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:692
Clinical outcome of patients with hip fracture and dementia. Data on 7876 patients from Swedish registry SveDem
Religa D; Hagg S; Gustavsson F; Hedstrom M
Conference publication: INNOVATION IN AGING. 2021;5:5
A COMPUTATIONAL SOLUTION TO BOLSTER EPIGENETIC CLOCK RELIABILITY FOR CLINICAL TRIALS AND LONGITUDINAL TRACKING
Higgins-Chen A; Thrush K; Hu-Seliger T; Wang Y; Hagg S; Levine M
Preprint: MEDRXIV. 2021
Using an electronic frailty index to predict adverse outcomes in geriatric COVID-19 patients: data from the Stockholm GeroCovid study
Mak J; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engström M; Johnson P; Lundberg LG; Åkesson E; Öberg CS; Olsson M; Cederholm T; Hägg S; Religa D; Jylhävä J
Preprint: MEDRXIV. 2021
Development of an electronic frailty index for hospitalized geriatric patients in Sweden
Mak J; Hägg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engström M; Johnson P; Lundberg LG; Åkesson E; Öberg CS; Olsson M; Cederholm T; Jylhävä J; Religa D
Preprint: MEDRXIV. 2021
The association between lymphocyte mitochondrial DNA abundance and Stroke: a combination of multivariable-adjusted survival and mendelian randomization analyses
Martens L; Luo J; Wermer M; van Dijk KW; Hägg S; Grassmann F; Noordam R; van Heemst D
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;51:E109-E110
GENETICS OF AGE-AT-ONSET IN MAJOR DEPRESSION
Harder A; Thi TDN; Mosing MA; Hagg S; Lu Y
Review: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):602-620
Technological readiness and implementation of genomic-driven precision medicine for complex diseases
Franks PW; Melen E; Friedman M; Sundstrom J; Kockum I; Klareskog L; Almqvist C; Bergen SE; Czene K; Hagg S; Hall P; Johnell K; Malarstig A; Catrina A; Hagstrom H; Benson M; Smith JG; Gomez MF; Orho-Melander M; Jacobsson B; Halfvarson J; Repsilber D; Oresic M; Jern C; Melin B; Ohlsson C; Fall T; Ronnblom L; Wadelius M; Nordmark G; Johansson A; Rosenquist R; Sullivan PF
Preprint: MEDRXIV. 2021
Low mitochondrial copy number drives atherogenic cardiovascular disease: evidence from prospective cohort analyses in the UK Biobank combined with Mendelian Randomization
Luo J; Noordam R; Jukema W; van Dijk KW; Hägg S; Grassmann F; Cessie SL; van Heemst D
Corrigendum: HUMAN GENETICS. 2021;140(6):863
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance (Dec, 10.1007/s00439-020-02249-w, 2020)
Hagg S; Jylhava J; Wang Y; Czene K; Grassmann F
Review: ELIFE. 2021;10:e63425
Sex differences in biological aging with a focus on human studies
Hagg S; Jylhava J
Preprint: BIORXIV. 2021
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
Higgins-Chen A; Thrush K; Wang Y; Kuo P-L; Wang M; Minteer C; Moore AZ; Bandinelli S; Vinkers C; Vermetten E; Rutten BPF; Geuze E; Okhuijsen-Pfeifer C; van der Horst M; Schreiter S; Gutwinski S; Luykx J; Ferrucci L; Crimmins E; Boks M; Hägg S; Hu-Seliger T; Levine M
Preprint: RESEARCH SQUARE. 2021
Epigenome-wide association study of level and change in cognitive abilities from midlife through late-life
Karlsson I; Ericsson M; Wang Y; Jylhävä J; Hägg S; Aslan AD; Reynolds C; Pedersen N
Preprint: MEDRXIV. 2021
Genetic heterogeneity and subtypes of major depression
Nguyen T-D; Harder A; Xiong Y; Kowalec K; Hägg S; Cai N; Kuja-Halkola R; Dalman C; Sullivan P; Lu Y
Preprint: BIORXIV. 2021
Within-sibship GWAS improve estimates of direct genetic effects
Howe L; Nivard M; Morris T; Hansen A; Rasheed H; Cho Y; Chittoor G; Lind P; Palviainen T; van der Zee M; Cheesman R; Mangino M; Wang Y; Li S; Klaric L; Ratliff S; Bielak L; Nygaard M; Reynolds C; Balbona J; Bauer C; Boomsma D; Baras A; Campbell A; Campbell H; Chen Z; Christofidou P; Dahm C; Dokuru D; Evans L; de Geus EJC; Giddaluru S; Gordon S; Harden P; Havdahl A; Hill D; Kerr S; Kim Y; Kweon H; Latvala A; Li L; Lin K; Martikainen P; Magnusson PKE; Mills M; Lawlor D; Overton J; Pedersen N; Porteous D; Reid J; Silventoinen K; Southey M; Mallard T; Tucker-Drob E; Wright M; Social Science Genetic Association Consortium; Within Family Consortium; Hewitt J; Keller M; Stallings M; Christensen K; Kardia SLR; Peyser P; Smith J; Wilson J; Hopper J; Hägg S; Spector T; Pingault J-B; Plomin R; Bartels M; Martin N; Justice A; Millwood I; Hveem K; Naess Ø; Willer C; Åsvold BO; Koellinger P; Kaprio J; Medland S; Walters R; Benjamin D; Turley P; Evans D; Smith GD; Hayward C; Brumpton B; Hemani G; Davies N
Preprint: MEDRXIV. 2020
Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education
Mak J; Reynolds C; Hägg S; Li X; Ericsson M; Pedersen N; Jylhävä J; Kuja-Halkola R
Preprint: MEDRXIV. 2020
Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: the effect of sampling
Mak J; Kuja-Halkola R; Wang Y; Hägg S; Jylhävä J
Preprint: BIORXIV. 2020
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance
Hägg S; Jylhävä J; Wang Y; Czene K; Grassmann F
Preprint: BIORXIV. 2020
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
van Dongen J; Hagenbeek F; Suderman M; Roetman P; Sugden K; Chiocchetti A; Ismail K; Mulder R; Hafferty J; Adams M; Walker R; Morris S; Lahti J; Küpers L; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip H; Jansen R; Baselmans B; Parmar P; Lowry E; Streit F; Sirignano L; Send T; Frank J; Jylhävä J; Wang Y; Mishra PP; Colins O; Corcoran D; Poulton R; Mill J; Hannon E; Arseneault L; Korhonen T; Vuoksimaa E; Felix J; Bakermans-Kranenburg M; Campbell A; Czamara D; Binder E; Corpeleijn E; González JR; Grazuleviciene R; Gutzkow K; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; BIOS Consortium; Kluft C; Davies G; Hakulinen C; Keltikangas-Järvinen L; Franke B; Freitag C; Konrad K; Hervas A; Fernández-Rivas A; Vetro A; Raitakari O; Lehtimäki T; Vermeiren R; Strandberg T; Räikkönen K; Snieder H; Witt S; Deuschle M; Pedersen N; Hägg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt T; Tiemeier H; van Ijzendoorn M; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans K; McIntosh A; Bartels M; Boomsma D
Preprint: BIORXIV. 2020
Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing
McCartney D; Min J; Richmond R; Lu A; Sobczyk M; Davies G; Broer L; Guo X; Jeong A; Jung J; Kasela S; Katrinli S; Kuo P-L; Matias-Garcia P; Mishra P; Nygaard M; Palviainen T; Patki A; Raffield L; Ratliff S; Richardson T; Robinson O; Soerensen M; Sun D; Tsai P-C; van der Zee M; Walker R; Wang X; Wang Y; Xia R; Xu Z; Yao J; Zhao W; Correa A; Boerwinkle E; Dugué P-A; Durda P; Elliott H; Gieger C; The Genetics of DNA Methylation Consortium; de Geus EJC; Harris S; Hemani G; Imboden M; Kähönen M; Kardia SLR; Kresovich J; Li S; Lunetta K; Mangino M; Mason D; McIntosh A; Mengel-From J; Moore AZ; Murabito J; NHLBI Trans-Omics for Precision Medicine (TOPMed) ; Ollikainen M; Pankow J; Pedersen N; Peters A; Polidoro S; Porteous D; Raitakari O; Rich S; Sandler D; Sillanpää E; Smith A; Southey M; Strauch K; Tiwari H; Tanaka T; Tillin T; Uitterlinden A; Van Den Berg D; van Dongen J; Wilson J; Wright J; Yet I; Arnett D; Bandinelli S; Bell J; Binder A; Boomsma D; Chen W; Christensen K; Conneely K; Elliott P; Ferrucci L; Fornage M; Hägg S; Hayward C; Irvin M; Kaprio J; Lawlor D; Lehtimäki T; Lohoff F; Milani L; Milne R; Probst-Hensch N; Reiner A; Ritz B; Rotter J; Smith J; Taylor J; van Meurs JBJ; Vineis P; Waldenberger M; Deary I; Relton C; Horvath S; Marioni R
Corrigendum: NATURE GENETICS. 2020;52(3):354
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk (vol 51, 404, 2019)
Jansen IE; Savage JE; Watanabe K; Bryois J; Williams DM; Steinberg S; Sealock J; Karlsson IK; Haegg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl IS; Andersen F; Bergh S; Bettella F; Bjornsson S; Braekhus A; Brathen G; de Leeuw C; Desikan RS; Djurovic S; Dumitrescu L; Fladby T; Hohman TJ; Jonsson PV; Kiddle SJ; Rongve A; Saltvedt I; Sando SB; Selbaek G; Shoai M; Skene NG; Snaedal J; Stordal E; Ulstein ID; Wang Y; White LR; Hardy J; Hjerling-Leffler J; Sullivan PF; van der Flier WM; Dobson R; Davis LK; Stefansson H; Stefansson K; Pedersen NL; Ripke S; Andreassen OA; Posthuma D
Conference publication: BEHAVIOR GENETICS. 2020;50(6):485-487
DNA methylation signatures of a broad spectrum of aggressive behavior: a meta-analysis of epigenome-wide studies across the lifespan
van Dongen J; Hagenbeek FA; Suderman M; Roetman P; Sugden K; Chiocchetti AG; Ismail K; Mulder RH; Hafferty J; Adams MJ; Walker RM; Morris SW; Lahti J; Kupers LK; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip HF; Jansen R; Baselmans BML; Parmar P; Lowry E; Streit F; Sirignano L; Send T; Frank J; Jylhava J; Wang Y; Mishra PP; Colins OF; Corcoran D; Poulton R; Mill J; Hannon EJ; Arseneault L; Korhonen T; Vuoksimaa E; Felix J; Bakermans-Kranenburg M; Campbell A; Czamara D; Binder E; Corpeleijn E; Ramon Gonzalez J; Grazuleviciene R; Gutzkow KB; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; Kluft C; Davies GE; Hakulinen C; Keltikangas-Jarvinen L; Franke B; Freitag CM; Konrad K; Hervas A; Fernandez-Rivas A; Vetro A; Raitakari O; Lehtimaki T; Vermeiren R; Strandberg T; Raikkonen K; Snieder H; Witt SH; Deuschle M; Pedersen NL; Hagg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt TE; Tiemeier H; van Ijzendoorn MH; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans KL; McIntosh AM; Bartels M; Boomsma D
Preprint: BIORXIV. 2019
Implicit bias is strongest when assessing top candidates
Andersson E; Hagberg C; Hägg S
Preprint: MEDRXIV. 2019
Drivers of Frailty from Adulthood into Old Age: Results from a 27-year Longitudinal Population-Based Study in Sweden
Raymond E; Reynolds C; Dahl Aslan A; Finkel D; Ericsson M; Hägg S; Pedersen N; Jylhävä J
Preprint: MEDRXIV. 2019
DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936
Seeboth A; McCartney D; Wang Y; Hillary R; Stevenson A; Walker R; Evans K; McIntosh A; Hägg S; Deary I; Marioni R
Preprint: BIORXIV. 2019
A decade of epigenetic change in aging twins: genetic and environmental contributions to longitudinal DNA methylation
Reynolds C; Tan Q; Munoz E; Jylhävä J; Hjelmborg J; Christiansen L; Hägg S; Pedersen N
Preprint: MEDRXIV. 2019
A Genome-Wide Association Study of the Frailty Index Highlights Synaptic Pathways in Aging
Atkins J; Jylhävä J; Pedersen N; Magnusson P; Lu Y; Wang Y; Hägg S; Melzer D; Williams D; Pilling L
Preprint: BIORXIV. 2019
Comprehensive longitudinal study of epigenetic mutations in aging
Wang Y; Karlsson R; Jylhävä J; Hedman Å; Almqvist C; Karlsson I; Pedersen N; Almgren M; Hägg S
Review: CURRENT OPINION IN CARDIOLOGY. 2019;34(3):270-274
Telomere length and cardiovascular disease risk
Zhan Y; Hagg S
Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):2068
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (vol 9, 2098, 2018)
Davies G; Lam M; Harris SE; Trampush JW; Luciano M; Hill WD; Hagenaars SP; Ritchie SJ; Marioni RE; Fawns-Ritchie C; Liewald DCM; Okely JA; Ahola-Olli AV; Barnes CLK; Bertram L; Bis JC; Burdick KE; Christoforou A; DeRosse P; Djurovic S; Espeseth T; Giakoumaki S; Giddaluru S; Gustavson DE; Hayward C; Hofer E; Ikram MA; Karlsson R; Knowles E; Lahti J; Leber M; Li S; Mather KA; Melle I; Morris D; Oldmeadow C; Palviainen T; Payton A; Pazoki R; Petrovic K; Reynolds CA; Sargurupremraj M; Scholz M; Smith JA; Smith AV; Terzikhan N; Thalamuthu A; Trompet S; van der Lee SJ; Ware EB; Windham BG; Wright MJ; Yang J; Yu J; Ames D; Amin N; Amouyel P; Andreassen OA; Armstrong NJ; Assareh AA; Attia JR; Attix D; Avramopoulos D; Bennett DA; Boehmer AC; Boyle PA; Brodaty H; Campbell H; Cannon TD; Cirulli ET; Congdon E; Conley ED; Corley J; Cox SR; Dale AM; Dehghan A; Dick D; Dickinson D; Eriksson JG; Evangelou E; Faul JD; Ford I; Freimer NA; Gao H; Giegling I; Gillespie NA; Gordon SD; Gottesman RF; Griswold ME; Gudnason V; Harris TB; Hartmann AM; Hatzimanolis A; Heiss G; Holliday EG; Joshi PK; Kahonen M; Kardia SLR; Karlsson I; Kleineidam L; Knopman DS; Kochan NA; Konte B; Kwok JB; Le Hellard S; Lee T; Lehtimaki T; Li S-C; Lill CM; Liu T; Koini M; London E; Longstreth WTJ; Lopez OL; Loukola A; Luck T; Lundervold AJ; Lundquist A; Lyytikainen L-P; Martin NG; Montgomery GW; Murray AD; Need AC; Noordam R; Nyberg L; Ollier W; Papenberg G; Pattie A; Polasek O; Poldrack RA; Psaty BM; Reppermund S; Riedel-Heller SG; Rose RJ; Rotter JI; Roussos P; Rovio SP; Saba Y; Sabb FW; Sachdev PS; Satizabal CL; Schmid M; Scott RJ; Scult MA; Simino J; Slagboom PE; Smyrnis N; Soumare A; Stefanis NC; Stott DJ; Straub RE; Sundet K; Taylor AM; Taylor KD; Tzoulaki I; Tzourio C; Uitterlinden A; Vitart V; Voineskos AN; Kaprio J; Wagner M; Wagner H; Weinhold L; Wen KH; Widen E; Yang Q; Zhao W; Adams HHH; Arking DE; Bilder RM; Bitsios P; Boerwinkle E; Chiba-Falek O; Corvin A; De Jager PL; Debette S; Donohoe G; Elliott P; Fitzpatrick AL; Gill M; Glahn DC; Hagg S; Hansell NK; Hariri AR; Ikram MK; Jukema JW; Vuoksimaa E; Keller MC; Kremen WS; Launer L; Lindenberger U; Palotie A; Pedersen NL; Pendleton N; Porteous DJ; Raikkonen K; Raitakari OT; Ramirez A; Reinvang I; Rudan I; Rujescu D; Schmidt R; Schmidt H; Schofield PW; Schofield PR; Starr JM; Steen VM; Trollor JN; Turner ST; Van Duijn CM; Villringer A; Weinberger DR; Weir DR; Wilson JF; Malhotra A; McIntosh AM; Gale CR; Seshadri S; Mosley THJ; Bressler J; Lencz T; Deary IJ
Preprint: BIORXIV. 2019
Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts
Sturm G; Cardenas A; Bind M-A; Horvath S; Wang S; Wang Y; Hägg S; Hirano M; Picard M
Preprint: BIORXIV. 2019
Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases
Brumpton B; Sanderson E; Hartwig FP; Harrison S; Vie GÅ; Cho Y; Howe L; Hughes A; Boomsma D; Havdahl A; Hopper J; Neale M; Nivard M; Pedersen N; Reynolds C; Tucker-Drob E; Grotzinger A; Howe L; Morris T; Li S; MR within-family Consortium; Chen W-M; Bjørngaard JH; Hveem K; Willer C; Evans D; Kaprio J; Åsvol BO; Smith GD; Åsvold BO; Hemani G; Davies N
Preprint: BIORXIV. 2019
Neuroticism as a predictor of frailty in old age: a genetically informative approach
Danielsdottir HB; Jylhävä J; Hägg S; Lu Y; Colodro-Conde L; Martin N; Pedersen N; Mosing M; Lehto K
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S218-S219
Early and late-life stress and longitudinal telomere length in old twins
Gerritsen L; Hagg S; Reynolds C; Pedersen N
Conference publication: BEHAVIOR GENETICS. 2019;49(6):532
Loneliness and DNA methylation of variants in the conserved transcriptional response to adversity (CTRA) pathway
Phillips D; Wang Y; Pedersen NL; Hagg S; Reynolds C
Conference publication: BEHAVIOR GENETICS. 2019;49(6):527
10-year epigenetic change: age-associated CpGs are differentially heritable
Reynolds C; Tan Q; Munoz E; Jylhava J; Hjelmborg J; Christiansen L; Hagg S; Pedersen NL
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:1114
CHILDHOOD ADOPTION AND MENTAL HEALTH IN ADULTHOOD: GENE-ENVIRONMENT INTERPLAY AND CROSS-TRAIT GENETIC OVERLAP WITH AFFECTIVE TRAITS IN UK BIOBANK
Lehto K; Hagg S; Karlsson R; Pedersen NL; Mosing MA
Conference publication: BEHAVIOR GENETICS. 2019;49(6):515
Neuroticism as a predictor of frailty in old age: a genetically informative approach
Bjork H; Jylhava J; Hagg S; Lu Y; Colodro-Conde L; Martin N; Pedersen NL; Mosing M; Lehto K
Conference publication: BEHAVIOR GENETICS. 2019;49(6):508-509
Childhood adoption and mental health in adulthood: the role of genetic confounding
Lehto K; Hagg S; Lu D; Karlsson R; Pedersen NL; Mosing M
Conference publication: BEHAVIOR GENETICS. 2019;49(6):503
DNA methylation and change in late-life cognitive abilities
Karlsson I; Ericsson M; Wang Y; Jylhava J; Hagg S; Aslan AD; Reynolds C; Pedersen NL
Preprint: BIORXIV. 2018
The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards
Li X; Ploner A; Karlsson I; Liu X; Magnusson PKE; Pedersen N; Hägg S; Jylhävä J
Review: AGEING RESEARCH REVIEWS. 2018;48:11-20
Telomere Length and All-Cause Mortality: A Meta-analysis
Wang Q; Zhan Y; Pedersen NL; Fang F; Hagg S
Preprint: BIORXIV. 2018
Profiles of circulating histidine-rich glycoprotein associate with chronological age and risk of all-cause mortality
Hong M-G; Dodig-Crnković T; Chen X; Drobin K; Lee W; Wang Y; Edfors F; Kotol D; Thomas CE; Sjöberg R; Odeberg J; Hamsten A; Silveira A; Hall P; Nilsson P; Pawitan Y; Hägg S; Uhlén M; Pedersen N; Magnusson P; Schwenk J
Preprint: BIORXIV. 2018
Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease risk
Jansen I; Savage J; Watanabe K; Bryois J; Williams D; Steinberg S; Sealock J; Karlsson I; Hägg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl I; Andersen F; Bergh S; Bettella F; Bjornsson S; Brækhus A; Bråthen G; de Leeuw C; Desikan R; Djurovic S; Dumitrescu L; Fladby T; Homan T; Jonsson P; Kiddle S; Rongve A; Saltvedt I; Sando S; Selbæk G; Skenne N; Snaedal J; Stordal E; Ulstein I; Wang Y; White L; Hjerling-Leffler J; Sullivan P; van der Flier W; Dobson R; Davis L; Stefansson H; Stefansson K; Pedersen N; Ripke S; Andreassen O; Posthuma D
Editorial comment: CIRCULATION RESEARCH. 2018;122(4):546-547
Telomere Length Dynamics and Atherosclerotic Disease
Hagg S
Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2018;26:749-750
Development of a robust method to study epigenetic changes in highly degraded FFPE DNA
Hertoghs K; Wang Y; Behrouz F; Graff C; van Wezel T; van Iterson M; Pedersen N; Hagg S; Janssen B
Preprint: F1000RES. 2018
Positive bias for European men in peer reviewed applications for faculty position at Karolinska Institutet
Holst S; Hägg S
Conference publication: HUMAN GENOMICS. 2018;12
GWAS meta-analysis (N=279,930) identifies new genes and functional links to general cognitive ability
Savage JE; Jansen PR; Stringer S; Watanabe K; Bryois J; de Leeuw CA; Nagel M; Awasthi S; Barr PB; Coleman JRI; Grasby KL; Hammerschlag AR; Kaminski J; Karlsson R; Krapohl E; Lam M; Nygaard M; Reynolds CA; Trampush JW; Young H; Zabaneh D; Hagg S; Hansell NK; Karlsson IK; Linnarsson S; Montgomery GW; Munoz-Manchado AB; Quinlan EB; Schumann G; Skene N; Webb BT; White T; Arking DE; Attix DK; Avramopoulos D; Bilder RM; Bitsios P; Burdick KE; Cannon TD; Chiba-Falek O; Christoforou A; Cirulli ET; Congdon E; Corvin A; Davies G; Deary IJ; DeRosse P; Dickinson D; Djurovic S; Donohoe G; Conley ED; Eriksson JG; Espeseth T; Freimer NA; Giakoumaki S; Giegling I; Gill M; Glahn DC; Hariri AR; Hatzimanolis A; Keller MC; Knowles E; Konte B; Lahti J; Le Hellard S; Lencz T; Liewald DC; London E; Lundervold AJ; Malhotra AK; Melle I; Morris D; Need AC; Ollier W; Palotie A; Payton A; Pendleton N; Poldrack RA; Raikkonen K; Reinvang I; Roussos P; Rujescu D; Sabb FW; Scult MA; Smeland OB; Smyrnis N; Starr JM; Steen VM; Stefanis NC; Straub RE; Sundet K; Voineskos AN; Weinberger DR; Widen E; Yu J; Abecasis G; Andreassen OA; Breen G; Christiansen L; Debrabant B; Dick DM; Heinz A; Hjerling-Leffler J; Ikram MA; Kendler KS; Martin NG; Medland SE; Pedersen NL; Plomin R; Polderman TJC; Ripke S; van der Sluis S; Sullivan PF; Tiemeier H; Vrieze SI; Wright MJ; Posthuma D
Preprint: BIORXIV. 2017
A frailty index for UK Biobank participants
Williams D; Jylhävä J; Pedersen N; Hägg S
Preprint: BIORXIV. 2017
Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins
Wang Y; Karlsson R; Lampa E; Zhang Q; Hedman Å; Almgren M; Almqvist C; McRae A; Marioni R; Ingelsson E; Visscher P; Deary I; Lind L; Morris T; Beck S; Pedersen N; Hägg S
Preprint: BIORXIV. 2017
The frailty index is associated with the need for care in an aging Swedish population
Jylhävä J; Jiang M; Foebel AD; Pedersen NL; Hägg S
Preprint: BIORXIV. 2017
Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort
Jiang M; Foebel AD; Kuja-Halkola R; Karlsson I; Pedersen NL; Hägg S; Jylhävä J
Preprint: BIORXIV. 2017
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Savage J; Jansen P; Stringer S; Watanabe K; Bryois J; de Leeuw C; Nagel M; Awasthi S; Barr P; Coleman J; Grasby K; Hammerschlag A; Kaminski J; Karlsson R; Krapohl E; Lam M; Nygaard M; Reynolds C; Trampush J; Young H; Zabaneh D; Hägg S; Hansell N; Karlsson I; Linnarsson S; Montgomery G; Muñoz-Manchado A; Quinlan E; Schumann G; Skene N; Webb B; White T; Arking D; Attix D; Avramopoulos D; Bilder R; Bitsios P; Burdick K; Cannon T; Chiba-Falek O; Christoforou A; Cirulli E; Congdon E; Corvin A; Davies G; Deary I; DeRosse P; Dickinson D; Djurovic S; Donohoe G; Conley ED; Eriksson J; Espeseth T; Freimer N; Giakoumaki S; Giegling I; Gill M; Glahn D; Hariri A; Hatzimanolis A; Keller M; Knowles E; Konte B; Lahti J; Hellard SL; Lencz T; Liewald D; London E; Lundervold A; Malhotra A; Melle I; Morris D; Need A; Ollier W; Palotie A; Payton A; Pendleton N; Poldrack R; Räikkönen K; Reinvang I; Roussos P; Rujescu D; Sabb F; Scult M; Smeland O; Smyrnis N; Starr J; Steen V; Stefanis N; Straub R; Sundet K; Voineskos A; Weinberger D; Widen E; Yu J; Abecasis G; Andreassen O; Breen G; Christiansen L; Debrabant B; Dick D; Heinz A; Hjerling-Leffler J; Ikram A; Kendler K; Martin N; Medland S; Pedersen N; Plomin R; Polderman TJC; Ripke S; Sluis SVD; Sullivan P; Tiemeier H; Vrieze S; Wright M; Posthuma D
Preprint: BIORXIV. 2017
Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Davies G; Lam M; Harris S; Trampush J; Luciano M; Hill D; Hagenaars S; Ritchie S; Marioni R; Fawns-Ritchie C; Liewald DCM; Okely J; Ahola-Olli A; Barnes CLK; Bertram L; Bis J; Burdick K; Christoforou A; DeRosse P; Djurovic S; Espeseth T; Giakoumaki S; Giddaluru S; Gustavson D; Hayward C; Hofer E; Ikram A; Karlsson R; Knowles E; Lahti J; Leber M; Li S; Mather K; Melle I; Morris D; Oldmeadow C; Palviainen T; Payton A; Pazoki R; Petrovic K; Reynolds C; Sargurupremraj M; Scholz M; Smith J; Smith A; Terzikhan N; Thalamuthu A; Trompet S; Lee SVD; Ware E; Windham G; Wright M; Yang J; Yu J; Ames D; Amin N; Amouyel P; Andreassen O; Armstrong N; Assareh A; Attia J; Attix D; Avramopoulos D; Bennett D; Böhmer A; Boyle P; Brodaty H; Campbell H; Cannon T; Cirulli E; Congdon E; Conley ED; Corley J; Cox S; Dale A; Dehghan A; Dick D; Dickinson D; Eriksson J; Evangelou E; Faul J; Ford I; Freimer N; Gao H; Giegling I; Gillespie N; Gordon S; Gottesman R; Griswold M; Gudnason V; Harris T; Hartmann A; Hatzimanolis A; Heiss G; Holliday E; Joshi P; Kähönen M; Kardia SLR; Karlsson I; Kleineidam L; Knopman D; Kochan N; Konte B; Kwok J; Hellard SL; Lee T; Lehtimäki T; Li S-C; Liu T; Koini M; London E; Longstreth W; Lopez O; Loukola A; Luck T; Lundervold A; Lundquist A; Lyytikäinen L-P; Martin N; Montgomery G; Murray A; Need A; Noordam R; Nyberg L; Ollier W; Papenberg G; Pattie A; Polasek O; Poldrack R; Psaty B; Reppermund S; Riedel-Heller S; Rose R; Rotter J; Roussos P; Rovio S; Saba Y; Sabb F; Sachdev P; Satizabal C; Schmid M; Scott R; Scult M; Simino J; Slagboom E; Smyrnis N; Soumaré A; Stefanis N; Stott D; Straub R; Sundet K; Taylor A; Taylor K; Tzoulaki I; Tzourio C; Uitterlinden A; Vitart V; Voineskos A; Kaprio J; Wagner M; Wagner H; Weinhold L; Wen H; Widen E; Yang Q; Zhao W; Adams HHH; Arking D; Bilder R; Bitsios P; Boerwinkle E; Chiba-Falek O; Corvin A; Jager PD; Debette S; Donohoe G; Elliott P; Fitzpatrick A; Gill M; Glahn D; Hägg S; Hansell N; Hariri A; Ikram K; Jukema W; Vuoksimaa E; Keller M; Kremen W; Launer L; Lindenberger U; Palotie A; Pedersen N; Pendleton N; Porteous D; Räikkönen K; Raitakari O; Ramirez A; Reinvang I; Rudan I; Rujescu D; Schmidt R; Schmidt H; Schofield P; Schofield P; Starr J; Steen V; Trollor J; Turner S; Duijn CV; Villringer A; Weinberger D; Weir D; Wilson J; Malhotra A; McIntosh A; Gale C; Seshadri S; Mosley T; Bressler J; Lencz T; Deary I
Review: EBIOMEDICINE. 2017;21:29-36
Biological Age Predictors
Jylhava J; Pedersen NL; Hagg S
Preprint: BIORXIV. 2017
An epigenome-wide association study of educational attainment (n= 10,767)
Karlsson Linnér R; Marioni R; Rietveld C; Simpkin A; Davies N; Watanabe K; Armstrong N; Auro K; Baumbach C; Bonder MJ; Buchwald J; Fiorito G; Ismail K; Iurato S; Joensuu A; Karell P; Kasela S; Lahti J; McRae A; Mandaviya P; Seppälä I; Wang Y; Baglietto L; Binder E; Harris S; Hodge A; Horvath S; Hurme M; Johannesson M; Latvala A; Mather K; Medland S; Metspalu A; Milani L; Milne R; Pattie A; Pedersen N; Peters A; Polidoro S; Räikkönen K; Severi G; Starr J; Stolk L; Waldenberger M; BIOS Consortium; Eriksson J; Esko T; Franke L; Gieger C; Giles G; Hägg S; Jousilahti P; Kaprio J; Kähönen M; Lehtimäki T; Martin N; van Meurs J; Ollikainen M; Perola M; Posthuma D; Raitakari O; Sachdev P; Taskesen E; Uitterlinden A; Vineis P; Wijmenga C; Wright M; Relton C; Davey Smith G; Deary I; Koellinger P; Benjamin D
Conference publication: BEHAVIOR GENETICS. 2017;47(6):706
Longitudinal variance components of the Horvath clock and its contributing CpGs
Jylhava J; Reynolds C; Hjelmborg J; Munoz E; Tan Q; Christiansen L; Hagg S; Pedersen NL
Conference publication: BEHAVIOR GENETICS. 2017;47(6):709
DNA methylation in Alzheimer's disease associated genes
Karlsson I; Ploner A; Wang Y; Pedersen NL; Hagg S
Letter: JAMA NEUROLOGY. 2015;72(10):1202-1203
Telomere Length Shortening and Alzheimer Disease-A Mendelian Randomization Study
Zhan Y; Song C; Karlsson R; Tillander A; Reynolds CA; Pedersen NL; Hagg S
Conference publication: BEHAVIOR GENETICS. 2015;45(6):664
Genetic susceptibility to cardiovascular disease and risk of dementia
Karlsson I; Haegg S; Ploner A; Song C; Gatz M; Pedersen N
Conference publication: THE GERONTOLOGIST. 2015;55
Apolipoprotein E DNA Methylation in Dementia and Cardiovascular Disease
Karlsson IK; Hagg S; Pedersen NL
Conference publication: ATHEROSCLEROSIS. 2014;235(2):E29
PLASMA CHOLESTEROL-INDUCED REGRESSION OF EARLY, MATURE, AND ADVANCED ATHEROSCLEROSIS
Bjorkegren JLM; Hagg S; Talukdar HA; Asl HF; Jain RK; Cedergren C; Shang MM; Rossignoli A; Takolander R; Melander O; Hamsten A; Michoel T; Skogsberg J
Preprint: BIORXIV. 2014
A workflow for UPLC-MS non-targeted metabolomic profiling in large human population-based studies
Ganna A; Fall T; Lee W; Broeckling CD; Kumar J; Hägg S; Magnusson PKE; Prenni J; Lind L; Pawitan Y; Ingelsson E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2013;42
Telomere length in circulating leukocytes is associated with lung function and disease
Schulz H; Sillanpaa E; Karrasch S; Alves AC; Codd V; Hovatta I; Buxton JL; Nelson CP; Broer L; Hagg S; Mangino M; Willemsen G; Pietilainen KH; Ferreira MAR; Amin N; Oostra BA; Backmand HM; Peltonen M; Sarna S; Rantanen T; Sipila S; Korhonen T; Madden PAF; Gieger C; Joerres RA; Heinrich J; Behr J; Huber RM; Peters A; Strauch K; Wichmann H-E; Waldenberger M; Blakemore AIF; de Geus EJC; Nyholt N; Henders AK; Piirila PL; Surakka I; Rissanen A; Magnusson PKE; Vinuela A; Martin NG; Pedersen NL; Boomsma DI; Spector TD; van Duijn CM; Kaprio J; Samani NJ; Jarvelin M-R; Albrecht E
Conference publication: DIABETOLOGIA. 2013;56:S60
Pleiotropic effects on lipid levels and obesity identified in multi-trait meta-analysis of genome-wide association studies (GWAS) of type 2 diabetes related traits
Lagou V; Maegi R; Surakka I; Sarin A-P; Horikoshi M; Thorleifsson G; Hagg S; Beekman M; Ladenvall C; Hottenga J-J; Ried JS; McCarthy MI; Morris A; Ripatti S; Prokopenko I
Conference publication: CIRCULATION. 2012;126(21)
Evidence of a Causal Relationship between Adiponectin Levels and Insulin Sensitivity: A Mendelian Randomization Study
Gao H; Fall T; van Dam RM; Flyvbjerg A; Zethelius B; Ingelsson E; Hagg S
Conference publication: GENETIC EPIDEMIOLOGY. 2012;36(7):776-777
Large-scale Genome-wide Association Meta-analysis Using Imputation from 2188-haplotype 1000 Genomes Reference Panel Identifies Novel Susceptibility Loci for Anthropometric and Glycemic Traits
Magi R; Horikoshi M; Surakka I; Wiltshire S; Sarin A-P; Mahajan A; Marullo L; Ferreira T; Hagg S; Ried JS; Winkler T; Thorleifsson G; Tsernikova N; Esko T; Willenborg C; Nelson CP; Beekman M; Willems SM; McCarthy MI; Morris AP; Lindgren CM; Ripatti S; Prokopenko I
Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):64
ATHEROSCLEROSIS REGRESSION IN A MOUSE MODEL WITH HUMAN-LIKE HYPERCHOLESTEROLEMIA
Bjoerkegren J; Haegg S; Maleki S; Shang M; Michoel T; Skogsberg J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):357
The Stockholm atherosclerosis gene expression (stage) study -: Multiorgan expression profiling in well-characterized coronary artery disease patients
Hägg S; Lundström J; Skogsberg J; Nilsson R; Hallén K; Noori P; Ivert T; Hamsten A; Tegnér J; Björkegren J
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Forskningsbidrag

A longitudinal approach to characterize loss of muscle mass and function in aging humans – the importance of peripheral nerve integrity- part 2
Swedish Research Council
1 January 2024 - 31 December 2026
Towards a pREcision medicine Approach to Target Alzheimer´s Disease and Related Dementias (TREAT-ADRD)
Swedish Research Council
1 January 2023 - 31 December 2027
The gut-brain axis in Parkinson’s disease - epidemiologic and genetic studies
Swedish Research Council
1 January 2023 - 31 December 2025
Mapping the heterogeneity of inherited risk factors for Alzheimer’s Disease
Swedish Research Council
1 January 2023 - 31 December 2025
Post-COVID in the most severely affected in the pandemic: older adults’ risk factors, medications and outcomes in large nationwide data
Swedish Research Council
1 December 2021 - 30 November 2025
The most severely affected in the COVID-19 pandemic: older adults’ risk profiles, medications, long-term consequences and vaccination in large nationwide data
Swedish Research Council
1 December 2021 - 30 November 2025
The effect of obesity on cardiovascular disease: mediation analysis with Mendelian randomization
Swedish Research Council
1 January 2021 - 31 December 2024
Wuhan Interaction with Stockholm Evidence-based Research (WISER) project on health perspectives in the older population facing the SARS-CoV-2 outbreak
Swedish Research Council
1 January 2021 - 31 December 2023
Drug repurposing for age-related diseases using Mendelian Randomizations on large individual-level genomic data
Swedish Research Council
1 January 2020 - 31 December 2022
Causes and consequences of body fat changes across the adult life span
Swedish Research Council
1 January 2017 - 31 December 2019
EPIGENETICS IN AGING: A LONGITUDINAL PERSPECTIVE
Swedish Research Council
1 January 2016 - 31 December 2019
The epigenetic effect dynamics of psychopathology during late adulthood
Deutsche Forschungsgemeinschaft
1 January 2016
Health development in late life: Towards a functional care of older people with multiple illnesses and disabilities through understanding patterns of change and their causes
Swedish Research Council
1 January 2013 - 31 December 2016

Anställningar

Lektor, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2023-

Examina och utbildning

Docent, Molekylär epidemiologi, Karolinska Institutet, 2015

Uppdrag

Vetenskaplig chef för core facilitet, LifeGene, Karolinska Institute, https://ki.se/forskning/lifegene, 2024-
Founding board member, The Nordic Aging Society (NAS), University of Copenhagen, https://www.nordicaging.org/, 2023-

Handledare

Karolina Gustavsson, Muti-omics of aging and risk for dementia, 2024
Bowen Tang
Katalin Vincze
Sara Licaj

Uppdrag i kommitté

Ordförande, Expertgruppen, Tvillingregistret, Karolinska Institute, https://ki.se/en/research/staff-and-management
Medlem, Styrgruppen, SIMPLER, Uppsala University, https://www.simpler4health.se/about-us/steering-committe/
Medlem, Executive group, Strategic research area in epidemiology and biostatistics, Karolinska Institute, https://ki.se/en/research/about-sfoepi

Redaktör för vetenskaplig tidskrift

Clinical epigenetics, Biträdande redaktör, https://clinicalepigeneticsjournal.biomedcentral.com/about/editorial-board, 2023

Expert

Evaluator of research applications in national competition, Swedish Research Council, 2024
Reviewer of candidates proposed for academic positions, University of Oulu, 2024
Evaluator of research applications in national competition, Public Health panel, Academy of Finland, 2023
Reviewer of candidates proposed for academic positions, Evaluator for fellowship, Medical Research Council, 2023
Evaluator of research applications in international competition, Different panels, National Institute on Aging, 2018

Konferenser och events

Ordförande, Gordon Research Conference (GRC) in Systems Aging, https://www.grc.org/systems-aging-conference/2024/, 2024
Ordförande, SFOepi conference - the future of epidemiology and biostatistics, https://ki.se/en/research/sfoepi-conference-the-future-of-epidemiology-and-biostatistics, 2024
Ordförande, The Nordic Aging Society - Symposium on Aging, 2024
Annat, The Nordic Congress on Gerontology, Member of the National Scientific Committee, https://www.nkg2024.se/national-scientific-committee/, 2024
Inbjuden föredragshållare, Aging Research and Drug Development (ARDD), https://agingpharma.org/, 2024
Inbjuden föredragshållare, Biomarkers of Aging Conference, https://www.agingconsortium.org/conference-2024, 2024
Inbjuden föredragshållare, Max Planck Freiburg Epigenetics meeting, https://events.ie-freiburg.mpg.de/, 2024

Om mig

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Examina och utbildning

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Handledare

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Redaktör för vetenskaplig tidskrift

Expert

Konferenser och events

Nyheter från KI

Kalenderhändelser från KI