Elisabet Svenungsson
Senior Forskare | Docent
E-postadress: elisabet.svenungsson@ki.se
Besöksadress: D2:01, Karolinska Universitetssjukhuset, 17176 Stockholm
Postadress: K2 Medicin, Solna, K2 Reuma Antovic A, 171 77 Stockholm
Om mig
- I studied medicine at Karolinska Institutet and did my internship at Örebro
hospital. Thereafter, I worked at Karolinska University Hospital as a
resident and became a specialist in Rheumatology and in Internal medicine in
1994. I have since worked with Rheumatology with a special interest in
systemic lupus erythematosus (SLE) and related systemic autoimmune diseases.
I defended my thesis on “Cardiovascular Disease in Systemic lupus
Erythematosus” in 2003.
During many years I worked with medical responsibility for the inpatient
rheumatology ward, and during that time I also organised the clinical
education for medical students in Rheumatology. Presently, I hold a position
as senior consultant and adjunct professor in Rheumatology. I split my time
between clinical work and clinical/translational research.
I have several international collaborations, and I am now the president of
SLEuro and a member of the international Systemic Lupus Erythematosus
International Collaborating Clinics (SLICC) group.
Forskningsbeskrivning
- *My research is mainly focused on: *
* Autoimmune mechanisms contributing to cardiovascular disease in SLE, in
the antiphospholipid syndrome (APS) and in the general population.
* Identifying sub-phenotypes in systemic lupus erythematosus (SLE)
Together with colleagues I initiated the Karolinska SLE cohort in 1995 and
the Karolinska APS cohort in 2009. Over the years we have collected
detailed clinical information and stored samples and information regarding
approximately 750 SLE patients, 200 APS patients and matched controls.
*Major lines of research *
We have studied why patients with systemic autoimmune diseases, primarily,
SLE, but also Systemic sclerosis (SSc) and APS, are affected with premature
cardiovascular disease. Our studies have demonstrated that pro-thrombotic
antiphospholipid antibodies (aPL), nephritis/impaired renal function,
systemic inflammation with endothelial activation as well as genetic
predisposition are SLE associated risk factors, which predict cardiovascular
mortality (CVM) and the first cardiovascular events in patients with SLE. In
a more recent study we could show that in comparison to age and gender
matched controls, it is only the SLE subgroup with nephritis (30-40%), which
is affected with accelerated atherosclerosis, measured as carotid plaques
with ultrasound. “Non-nephritis” SLE patients did not differ from
controls regarding carotid plaques.
We have also demonstrated that genetic susceptibility is important for SLE
associated CVD. This work has identified STAT4, HLA-DRB1*04 and HLADRB1*13 as
risk alleles for SLE associated CVD and the same risk alleles were also
associated with pro-thrombotic (aPL) in SLE patients.
A more recent research focus has been to identify more homogeneous sub-groups
among patients with SLE. Using various types of cluster analyses we have
demonstrated that there are several fairly distinct subgroups of SLE
patients. In particular we have studied differences between patients with SLE
and APS and patients with SLE and Sjögren’s syndrome. Notably there is
very little overlap between these two groups.
*Selected publications:*
1) Svenungsson E, Gustafsson JT, Grosso G, Rossides M, Gunnarsson I,
Jensen-Urstad K, et al. Complement deposition, C4d, on platelets is
associated with vascular events in systemic lupus erythematosus.
Rheumatology (Oxford). 2020.
2) Grosso G, Sippl N, Kjellstrom B, Amara K, de Faire U, Elvin K, et al.
Antiphospholipid Antibodies in Patients With Myocardial Infarction. Ann
Intern Med. 2019(170):277-80.
3) Idborg H, Eketjall S, Pettersson S, Gustafsson JT, Zickert A, Kvarnstrom
M, et al. TNF-alpha and plasma albumin as biomarkers of disease activity
in systemic lupus erythematosus. Lupus science & - medicine.
2018 - 5(1):e000260.
4) Gustafsson JT, Herlitz Lindberg M, Gunnarsson I, Pettersson S, Elvin K,
Ohrvik J, et al. Excess atherosclerosis in systemic lupus
erythematosus, -A matter of renal involvement: Case control study of 281
SLE patients and 281 individually matched population controls. PLoS One.
2017 - 12(4):e0174572.
5) Gustafsson JT, Gunnarsson I, Kallberg H, Pettersson S, Zickert A,
Vikerfors A, et al. Cigarette smoking, antiphospholipid antibodies and
vascular events in Systemic Lupus Erythematosus. Ann Rheum Dis.
2015 - 74(8):1537-43.
6) Lundstrom E, Gustafsson JT, Jonsen A, Leonard D, Zickert A, Elvin K, et
al. HLA-DRB1*04/*13 alleles are associated with vascular disease and
antiphospholipid antibodies in systemic lupus erythematosus. Annals of
the rheumatic diseases. 2013 - 72(6):1018-25.
Artiklar
- Article: LUPUS. 2024;33(11):1192-1202
- Article: ARTHRITIS & RHEUMATOLOGY. 2024
- Article: JOURNAL OF CLINICAL PERIODONTOLOGY. 2024
- Article: QJM - MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS. 2024;117(8):581-588
- Article: THE LANCET RHEUMATOLOGY. 2024;6(7):e447-e459
- Article: RHEUMATOLOGY. 2024;:keae332
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2024;53(3):199-206
- Article: RHEUMATOLOGY. 2024;:keae168
- Article: RHEUMATOLOGY. 2024;:keae134
- Article: ARTHRITIS RESEARCH & THERAPY. 2024;26(1):65
- Article: JOURNAL OF AUTOIMMUNITY. 2024;143:103166
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2024;83(1):15-29
- Article: BEST PRACTICE AND RESEARCH: CLINICAL RHEUMATOLOGY. 2023;37(4):101893
- Article: CLINICAL RHEUMATOLOGY. 2023;42(11):2981-2986
- Article: CLINICAL IMMUNOLOGY. 2023;255:109763
- Article: ARTHRITIS RESEARCH & THERAPY. 2023;25(1):107
- Article: ARTHRITIS CARE AND RESEARCH. 2023;75(5):998-1006
- Article: RHEUMATOLOGY. 2023;62(3):1187-1196
- Article: LUPUS. 2023;32(2):252-262
- Article: RHEUMATOLOGY. 2023;62(2):924-933
- Article: SCANDINAVIAN CARDIOVASCULAR JOURNAL. 2022;56(1):337-342
- Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(11):1842-1850
- Article: LUPUS SCIENCE AND MEDICINE. 2022;9(1):e000752
- Article: LUPUS SCIENCE AND MEDICINE. 2022;9(1):e000744
- Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(8):1440-1450
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(6):768-779
- Article: JOURNAL OF RHEUMATOLOGY. 2022;49(5):465-469
- Article: JOURNAL OF INTERNAL MEDICINE. 2022;291(3):327-337
- Article: LUPUS SCIENCE AND MEDICINE. 2022;9(1):e000607
- Article: JOURNAL OF CLINICAL MEDICINE. 2022;11(4):1008
- Article: ACR OPEN RHEUMATOLOGY. 2022;4(1):27-39
- Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(10):1299-1309
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(9):1183-1189
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(9):1175-1182
- Article: LUPUS SCIENCE AND MEDICINE. 2021;8(1):e000510
- Article: LUPUS SCIENCE AND MEDICINE. 2021;8(1):e000515
- Article: GENES AND IMMUNITY. 2021;22(3):194-202
- Article: LUPUS SCIENCE AND MEDICINE. 2021;8(1):e000471
- Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):132
- Article: ARTHRITIS CARE AND RESEARCH. 2021;73(4):574-579
- Article: RHEUMATOLOGY. 2021;60(3):1445-1455
- Article: ARCHIVES OF RHEUMATOLOGY. 2021;36(1):89-100
- Article: LUPUS SCIENCE AND MEDICINE. 2021;8(1):e000463
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:702037
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1312
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:627986
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2021;29(1):184-193
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(1):109-117
- Article: SCIENTIFIC REPORTS. 2020;10(1):21126
- Article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2020;50(6):1387-1393
- Article: RHEUMATOLOGY. 2020;59(11):3264-3274
- Article: RHEUMATOLOGY. 2020;59(9):2237-2249
- Article: JOURNAL OF RHEUMATOLOGY. 2020;47(6):865-875
- Article: MUSCULOSKELETAL CARE. 2020;18(2):150-160
- Article: RHEUMATOLOGY. 2020;59(5):968-978
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(3):363-369
- Article: CLINICAL IMMUNOLOGY. 2020;212:108349-87
- Article: DIABETES AND VASCULAR DISEASE RESEARCH. 2020;17(3):1479164120922123-147916412092212
- Article: EUROPEAN JOURNAL OF NEUROLOGY. 2020;27(2):297-307
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(2):254-261
- Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(1):67-77
- Article: BIOLOGY OF SEX DIFFERENCES. 2019;10(1):60
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(10):1363-1370
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16955-16960
- Article: DIABETES CARE. 2019;42(8):1504-1511
- Article: JOURNAL OF AUTOIMMUNITY. 2019;102:142-149
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):107
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2019;48(2):141-148
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27(3):432-441
- Article: JOURNAL OF PROTEOME RESEARCH. 2019;18(3):1208-1217
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):62
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):60
- Article: HUMAN GENETICS. 2019;138(2):141-150
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:7
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;194(1):27-38
- Article: LUPUS. 2018;27(9):1470-1478
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(7):1063-1069
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(5):736-743
- Article: ATHEROSCLEROSIS. 2018;270:1-7
- Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):36
- Article: LUPUS SCIENCE AND MEDICINE. 2018;5(1):e000260
- Article: LUPUS SCIENCE AND MEDICINE. 2018;5(1):e000254
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2017;46(6):490-495
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2017;46(6):474-483
- Article: JOURNAL OF RHEUMATOLOGY. 2017;44(11):1590-1596
- Article: CLINICAL IMMUNOLOGY. 2017;183:304-315
- Article: THROMBOSIS RESEARCH. 2017;158:168-173
- Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2017;15(9):1799-1806
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(9):1607-1613
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(9):1544-1549
- Article: SCIENTIFIC REPORTS. 2017;7(1):6236
- Article: NATURE COMMUNICATIONS. 2017;8:16021
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2017;46(4):263-272
- Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):139
- Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(6):1272-1279
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2017;46(3):226-235
- Article: METABOLOMICS. 2017;13(10):114
- Article: PAEDIATRIC AND PERINATAL EPIDEMIOLOGY. 2017;31(1):29-36
- Article: SCIENTIFIC REPORTS. 2016;6:36025
- Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(8):1970-1980
- Article: CKJ: CLINICAL KIDNEY JOURNAL. 2016;9(4):552-555
- Article: ARTHRITIS CARE AND RESEARCH. 2016;68(7):988-994
- Article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2016;45(6):684-690
- Article: CIRCULATION. 2016;133(6):576-583
- Article: BMJ OPEN. 2016;6(1):e007769
- Article: PLOS ONE. 2016;11(6):e0158076
- Article: LUPUS SCIENCE AND MEDICINE. 2016;3(1):e000170
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;82(3):269-274
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2015;181(3):417-426
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(8):1537-1543
- Article: LUPUS. 2015;24(9):955-965
- Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):109
- Article: LUPUS SCIENCE AND MEDICINE. 2015;2(1):e000061
- Article: ARTHRITIS CARE AND RESEARCH. 2014;66(11):1710-1717
- Article: THROMBOSIS RESEARCH. 2014;133(5):936-944
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43(3):221-225
- Article: LUPUS SCIENCE AND MEDICINE. 2014;1(1):e000018
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2013;21(9):994-999
- Article: ARTHRITIS RESEARCH & THERAPY. 2013;15(4):R87
- Article: GENES AND IMMUNITY. 2013;14(4):217-222
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(6):1018-1025
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2013;6(3):255-263
- Article: LUPUS. 2013;22(5):477-485
- Article: LUPUS. 2013;22(3):307-311
- Article: RHEUMATOLOGY. 2013;52(3):501-509
- Article: PLOS ONE. 2013;8(12):e84450
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2012;41(5):383-390
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2012;41(4):290-297
- Article: LUPUS. 2012;21(7):802-805
- Article: LAKARTIDNINGEN. 2012;109(1-2):27-29
- Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(2):R46
- Article: ARTHRITIS & RHEUMATOLOGY. 2011;63(12):3942-3951
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(4):479-484
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2011;40(5):363-372
- Article: ARTHRITIS RESEARCH & THERAPY. 2011;13(6):r206
- Article: RHEUMATOLOGY. 2010;49(10):1935-1942
- Article: LUPUS. 2010;19(10):1187-1194
- Article: HUMAN MOLECULAR GENETICS. 2010;19(16):3282-3294
- Article: PLOS ONE. 2010;5(5):e10559
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2010;69(5):834-840
- Article: PLOS ONE. 2009;4(12):e8037
- Article: NATURE GENETICS. 2009;41(11):1228-1U93
- Article: ANNALS OF INTERNAL MEDICINE. 2009;150(10):670-6U3
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2009;38(3):184-189
- Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(6):R186
- Article: HUMAN MOLECULAR GENETICS. 2008;17(18):2868-2876
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2008;37(5):352-359
- Article: RHEUMATOLOGY. 2008;47(8):1144-1150
- Article: HUMAN MOLECULAR GENETICS. 2008;17(6):872-881
- Article: NATURE GENETICS. 2008;40(2):211-216
- Article: HLA. 2007;70(5):412-414
- Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(9):3080-3086
- Article: RHEUMATOLOGY. 2007;46(9):1417-1421
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(16):6758-6763
- Article: GENES AND IMMUNITY. 2007;8(1):69-74
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2006;65(9):1237-1240
- Article: GENES AND IMMUNITY. 2005;6(8):658-662
- Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(1):192-200
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2005;25(1):198-203
- Article: ATHEROSCLEROSIS. 2004;177(2):409-414
- Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(9):2869-2876
- Article: ARTHRITIS RESEARCH & THERAPY. 2004;6(2):R129-R136
- Article: LUPUS. 2003;12(6):454-461
- Article: NATURE GENETICS. 2002;32(4):666-669
- Article: LUPUS. 2002;11(11):744-752
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(3):561-566
- Article: CIRCULATION. 2001;104(16):1887-1893
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2001;60(4):372-379
- Article: GENOMICS. 2000;70(3):307-314
- Article: GENES AND IMMUNITY. 2000;1(6):380-385
- Article: JOURNAL OF AUTOIMMUNITY. 2000;14(2):169-178
- Article: JOURNAL OF RHEUMATOLOGY. 1999;26(10):2148-2152
- Article: ANNALS OF THE RHEUMATIC DISEASES. 1999;58(10):623-629
- Article: LUPUS. 1999;8(2):142-150
- Article: ANNALS OF NEUROLOGY. 1998;44(4):704-706
- Article: AMERICAN JOURNAL OF MEDICINE. 1998;104(4):332-338
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Alla övriga publikationer
- Letter: RHEUMATOLOGY. 2024;:keae353
- Editorial comment: THE LANCET RHEUMATOLOGY. 2023;5(9):e501-e506
- Review: LUPUS SCIENCE AND MEDICINE. 2021;8(1):e000590
- Corrigendum: NATURE REVIEWS. RHEUMATOLOGY. 2021;17(10):642
- Review: NATURE REVIEWS. RHEUMATOLOGY. 2021;17(9):515-532
- Letter: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(3):404-406
- Letter: LUPUS SCIENCE AND MEDICINE. 2020;7(1):e000415
- Review: JOURNAL OF INTERNAL MEDICINE. 2020;287(4):349-372
- Published conference paper: AUTOIMMUNITY REVIEWS. 2019;18(12):102401
- Review: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(10):1296-1304
- Review: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(6):736-745
- Letter: ANNALS OF INTERNAL MEDICINE. 2019;170(4):277-280
- Review: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2018;48(12):e13010
- Letter: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(10):e72
- Letter: JOURNAL OF RHEUMATOLOGY. 2018;45(7):1070
- Review: LUPUS SCIENCE AND MEDICINE. 2018;5(1):e000197
- Review: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(3):476-485
- Review: AUTOIMMUNITY REVIEWS. 2016;15(3):203-209
- Review: AUTOIMMUNITY REVIEWS. 2015;14(10):952-969
- Review: AUTOIMMUNITY. 2014;47(2):67-76
- Letter: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2012;41(2):158-160
- Meeting abstract: THROMBOSIS RESEARCH. 2011;127:S138
- Meeting abstract: MOLECULAR IMMUNOLOGY. 2010;47(13):2285
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):62
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):299
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2005;6(1):90
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2005;6(1):65-66
- Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S53
- Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S51-S52
- Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S45
- Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:p105-S40
- Thesis / dissertation: 2003
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):317
- Published conference paper: JOURNAL OF AUTOIMMUNITY. 1999;13(1):137-141
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Anställningar
- Senior Forskare, Medicin, Solna, Karolinska Institutet, 2024-2025
Examina och utbildning
- Docent, Reumatologi, Karolinska Institutet, 2010
- MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 2003
Handledare
- Esin Ylmaz, The impact of female hormonal fluctuations on SLE features and damage, 2023
- Sara Brolin, Educational needs, quality of life, and health care support in persons with systemic rheumatic disease, 2023
- Natali Karandyszowska, Diagnostic and therapeutic challenges in patients with antiphospholipid syndrome, 2021