Ujjwal Neogi

Ujjwal Neogi

Senior Lecturer | Docent
Visiting address: Alfred Nobels alle 8, 14183 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Klin Mikrobiologi Ujjwal Neogi, 141 52 Huddinge
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About me

  • I am a molecular and systems virologist with expertise in immunometabolism. In 2018, I founded the Systems Virology lab at Karolinska Institute, establishing a state-of-the-art interdisciplinary research platform that integrates computational biology, engineering, and clinical science. The primary goal of this initiative is to advance our understanding of viral pathogenesis. My lab pioneered in understanding metabolic rewiring in RNA virus infection by using systems biology studies and fingerprinting those using in vitro and in vivo studies. We aim to identify the molecular mechanisms of the natural control, primarily in HIV, and to develop novel functional cure strategies by engineering the metabolic state of the immune cells. We expanded our study to other pathogen including SARS-CoV-2, Crimean–Congo hemorrhagic fever viruses (CCHF), Japanese encephalitis viruses (JEV) and Dengue viruses.

Research

  • Employing system analysis of multi-omics technologies, our research group strives to uncover the molecular mechanisms underlying viral adaptation within the host and to pinpoint innovative biomarkers indicative of natural immune control against RNA viruses. Our goal is to identify key components of the immune response essential for natural immune protection and disease severity. This knowledge can be translated into the future development of vaccines and antiviral strategies, particularly against emerging and re-emerging viruses such as human immunodeficiency viruses (HIV), Crimean–Congo hemorrhagic fever (CCHF) viruses, dengue viruses, Zika viruses, and more recently, SARS-CoV-2.

    Using a similar high-throughput research methodology, our group also focuses on deciphering the mechanism of inflamm-aging in people living with HIV (PLHIV) who are on successful therapy. The aim is to identify biomarkers that could potentially guide future clinical interventions.

Teaching

  • As a teacher, I aim to inspire students by igniting their imagination and quest for the unknown and love to learn something new. When I started my Doctoral education at Karolinska Institute in 2010, I was placed in a hospital (St. John's Medical College and Hospital, SJMCH) in Bangalore, India, to establish a molecular biology lab to support a European Union framework program (EU-FP7) funded clinical trial on mobile phone intervention to improve drug adherence. I continued my passion for teaching and started teaching medical students at Karolinska Institute and SJMCH molecular biological techniques. During this time, I was also part of an African/Asian Regional Capacity Development (ARCADE) project to develop a new research training capacity on social determinants of health (RSDH) in LMICs in Asia. The teaching mode was blended teaching, and I developed a course on HIV epidemiology. In 2015, I participated in the research school for clinicians as a lecturer. This course is at Karolinska Institute and focuses on molecular medicine, cell, and molecular biology for clinically active persons emphasizing translational experimental research. In the first year (2015), I taught upcoming clinicians molecular biology processes in lecture classes. In the second year (2017), I merged theory with practical sessions and observed that the students were more engaged and interested in learning with this approach. I also participated in the Erasmus+ mobility international teacher exchange program at The Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, Portugal. Since 2015, I have taught biomedical laboratory technology, emerging and re-emerging viral diseases. Finally, I have significant teaching experience supervising doctoral, master's, and high school students since 2014.

Articles

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Grants

Employments

  • Senior Lecturer, Department of Laboratory Medicine, Karolinska Institutet, 2024-

Degrees and Education

  • Docent, Karolinska Institutet, 2018
  • Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2013

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