Ujjwal Neogi

Ujjwal Neogi

Senior Lecturer | Docent
Visiting address: Alfred Nobels alle 8, 14183 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Klin Mikrobiologi Ujjwal Neogi, 141 52 Huddinge
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About me

  • I am a molecular and systems virologist with expertise in immunometabolism. In 2018, I founded the Systems Virology lab at Karolinska Institute, establishing a state-of-the-art interdisciplinary research platform that integrates computational biology, engineering, and clinical science. The primary goal of this initiative is to advance our understanding of viral pathogenesis. My lab pioneered in understanding metabolic rewiring in RNA virus infection by using systems biology studies and fingerprinting those using in vitro and in vivo studies. We aim to identify the molecular mechanisms of the natural control, primarily in HIV, and to develop novel functional cure strategies by engineering the metabolic state of the immune cells. We expanded our study to other pathogen including SARS-CoV-2, Crimean–Congo hemorrhagic fever viruses (CCHF), Japanese encephalitis viruses (JEV) and Dengue viruses.

Research

  • Employing system analysis of multi-omics technologies, our research group strives to uncover the molecular mechanisms underlying viral adaptation within the host and to pinpoint innovative biomarkers indicative of natural immune control against RNA viruses. Our goal is to identify key components of the immune response essential for natural immune protection and disease severity. This knowledge can be translated into the future development of vaccines and antiviral strategies, particularly against emerging and re-emerging viruses such as human immunodeficiency viruses (HIV), Crimean–Congo hemorrhagic fever (CCHF) viruses, dengue viruses, Zika viruses, and more recently, SARS-CoV-2.

    Using a similar high-throughput research methodology, our group also focuses on deciphering the mechanism of inflamm-aging in people living with HIV (PLHIV) who are on successful therapy. The aim is to identify biomarkers that could potentially guide future clinical interventions.

Teaching

  • I want to integrate teaching at the level of bachelor's, master's, and doctoral studies in virology and system biology by participating in lectures, seminars, and practical courses. Depending on the teaching modules already available, I could provide teaching in molecular and clinical virology, emerging and re-emerging infectious diseases, system biology in infectious diseases, diagnostic virology, and molecular virology. I have already taught RNA viruses, molecular epidemiology of emerging and re-emerging viruses, diagnostics microbiology, and application of omics in infectious diseases. Apart from that, I aim to teach the concept of immune aging in infectious diseases. Finally, I also aim to provide training for projects, as well as bachelor's and master's students, by hosting them in my laboratory for short-term research projects in the wet lab and dry lab. Apart from that, I aim to supervise doctoral students and postdoc fellows.

    Manipal Institute of Virology, Karnataka, India (Since 2021): Master's in Clinical Virology, MIV610 Virological Technology, MIV512 Emerging and Re-emerging viruses. MIV509/511: Systematic Virology. (Lecture, Assignments, Seminar, Exam, 60h every semester). MIV512 received an average rating of 4.8 out of 5 from the students.

    Karolinska Institute, Stockholm, Sweden (Since 2015): First Cycle: Integrated Biomedical Laboratory Science (1BA127), Microbiology 2 (1BA061), Microbial pathogenesis (2TL008), Microbiology - Methodology and Diagnostics (1BA124), Microbial pathogenesis (2TL062). Second Cycle: Infection Biology (1BA124) Stockholm University, Third Cycle: Graduate School in Molecular Medicine for Clinicians (Lectures, Seminar, Practical, Laboratory). 

Articles

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Grants

Employments

  • Senior Lecturer, Department of Laboratory Medicine, Karolinska Institutet, 2024-

Degrees and Education

  • Docent, Karolinska Institutet, 2018
  • Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2013

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