Michael Yi Bonner

My current project focuses on changes in the REDOX environment of leukocytes
that stem from the Nox2 complex in murine cancer models. Specifically, I am
focused on understanding how murine cancer models develop slower in mice
carrying mutations in the Ncf1 (p47-phox) gene, a key component of the Nox2
complex controlling for production of superoxide /hydrogen peroxide in
leukocytes which is also mutated in approximately 23% of patients diagnosed
with chronic granulomatous disease (CGD).