Division of Virology and Immunology- Research Groups
Regulation of Gene Expression during Viral Infection
Our research concerns the study of the interactions between viruses and their host cells in the early stages of infection. Using Semliki Forest virus as a model, we are exploring the involvement of cellular pathways such as autophagy, stress granules and the type I interferon system in the cellular responses to viral infection.
Regulation of Gene Expression during Viral Infection – Gerald McInerney Group
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Gerald Mc Inerney
Division Head and Research Group LeaderGenetic basis for B and T cell recognition and function
Our research focuses on adaptive immune responses and qualitative properties of B- and T-cell repertoires. A specific interest in the group is to understand individual variation in germline V, D and J genes and how this influences antigen-specific responses in the context of infection, vaccination and autoimmunity.
Genetic basis for B and T cell recognition and function – Gunilla Karlsson Hedestam Group
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Gunilla Karlsson Hedestam
Research Group LeaderInflammatory responses in cancer and autoimmunity
Autoinflammation is part of several types of diseases. It drives auto-reactive B cells that contribute to autoimmune disease and create an environment in which tumors are allowed to grow. Our group studies the innate mechanism that are connected to this with special focus on B cells and Macrophages.
Inflammatory responses in cancer and autoimmunity – Mikael Karlsson's Group
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Mikael Karlsson
Research Group LeaderImmunodeficiency Diseases
The overall goal of our research is to understand how a compromised immune system leads to immunodeficiency with high incidence of autoimmunity and hematological cancers. We have a particular focus on how inborn mutations in actin regulators affect immune cell-cell communication, trafficking, and maintenance of genomic stability. Our research aims at revealing critical mechanisms for correct regulation of the immune system in health and disease and to identifying new targets for therapy.
Immunodeficiency Diseases – Lisa Westerberg Group