Animal experimental core facilities
At Karolinska Institutet, the managing organisation for all aspects of animal experimentation in research is Comparative Medicine. Our scientists also have access to animal facilities managed by the Karolinska University Hospital.
Core Facility for Germ-free Research
Germ-free (GF) mice are derived and raised in an environment devoid of resident bacterial flora (microbiota). At Karolinska Institutet, GF models are housed at the Core Facility for Germ-free Research (CFGR). This core facility is a part of the Karolinska Institutet Mouse Models (KIMM), and offers its services to academic researchers as well as to biotech and pharmaceutical industries.
The KIMM Import Portal (Portalen in Swedish) is the animal quarantine core facility within the Karolinska Institutet Mouse Models (KIMM) organisation.
Manipulation of gene expression during mouse development is a powerful tool for querying the role of specific genes in development and disease. Infinigene is a facility which utilizes ultrasound-guided nano-injection to introduce DNA-modifying agents during embryonic development, or in adult mice.
Karolinska Experimental Research and Imaging Centre
Karolinska Experimental Research and Imaging Centre (KERIC) conducts Imaging analyses in experimental systems in combination with experimental surgery in large animals like swine as well as in rodents. This facility is managed by the Karolinska University Hospital in Solna (North Campus area).
Karolinska Institutet Mouse Models
The Karolinska Institutet Mouse Models (KIMM) is a core facility umbrella offering production, phenotype analyses, archiving of mouse mutants and experimental platforms to understand the role of genes and the microbiota. The KIMM umbrella facility includes the KCTT facility, the Germ-free facility, the Mouse Clinic, and an import portal.
Morphological Phenotype Analysis
Morphological Phenotype Analysis (FENO) facility specialises in the pathology of genetically engineered mice. This core facility is managed by the Karolinska University Hospital in Felmingsberg (South Campus area).
The mouse clinic of KIMM (KICM) offers researchers the possibility to document the health of their genetically modified mouse strains according to international standards. Researchers may also chose between select analyses or a combination of analyses such as hematological-, physiological- and pathological and/or behavioural analyses.
Murine Stem Cells Unit
Murine Stem Cells Unit (MSCU) provides services in the field of mouse embryonic stem cells and related techniques including characterization, differentiation, and cryopreservation of genetically modified mouse embryonic stem cell (mESC) lines. MSCU is a well-resourced laboratory with all the equipment necessary to conduct experiment in pre-implantation embryology and stem cells.
Preclinical Laboratory Portal
The Preclinical Laboratory (PKL) offers cryopreservation techniques and re-derivation services. Managed by the Karolinska University Hospital in Huddinge (South Campus area).
The Karolinska Center for Transgene Technologies (KCTT) offers generation and storage of genetically modified mice and related techniques. The KCTT facility is a part of Karolinska Institutet Mouse Models (KIMM).
Zebrafish Core Facility
The Zebrafish Core Facility provides researchers with fish from wildtype lines, as well as offer the possibility of bringing in mutant/transgenic fish lines of interest from other laboratories.