Proteindynamik och mutationer – Laura Orellanas forskargrupp

Publikationer

Utvalda publikationer

• Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:890851

  Exploring the Conformational Impact of Glycine Receptor TM1-2 Mutations Through Coarse-Grained Analysis and Atomistic Simulations

  Mhashal AR; Yoluk O; Orellana L
• Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(2):108-120

  Structure, mechanism and lipid-mediated remodeling of the mammalian Na⁺/H⁺ exchanger NHA2

  Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Robinson CV; Nomura N; Iwata S; Landreh M; Orellana L; Beckstein O; Drew D
• Book chapter: ADVANCES IN PROTEIN MOLECULAR AND STRUCTURAL BIOLOGY METHODS. 2022;p. 199-212

  Chapter 13 Computational techniques to study protein dynamics and conformations

  Mhashal A; Emperador A; Orellana L
• Article: NATURE COMMUNICATIONS. 2021;12(1):1728

  Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis

  Thulasingam M; Orellana L; Nji E; Ahmad S; Rinaldo-Matthis A; Haeggstrom JZ
• Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2019;6:117

  Large-Scale Conformational Changes and Protein Function: Breaking the in silico Barrier

  Orellana L
• Article: MOLECULAR & CELLULAR ONCOLOGY. 2019;6(5):e1630798

  Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy

  Orellana L
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(20):10009-10018

  Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope

  Orellana L; Thorne AH; Lema R; Gustavsson J; Parisian AD; Hospital A; Cordeiro TN; Bernado P; Scott AM; Brun-Heath I; Lindahl E; Cavenee WK; Furnari FB; Orozco M
• Article: CANCER CELL. 2018;34(1):163-177.e7

  Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development

  Binder ZA; Thorne AH; Bakas S; Wileyto EP; Bilello M; Akbari H; Rathore S; Ha SM; Zhang L; Ferguson CJ; Dahiya S; Bi WL; Reardon DA; Idbaih A; Felsberg J; Hentschel B; Weller M; Bagley SJ; Morrissette JJD; Nasrallah MP; Ma J; Zanca C; Scott AM; Orellana L; Davatzikos C; Furnari FB; O'Rourke DM
• Article: NATURE COMMUNICATIONS. 2016;7:12575

  Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations

  Orellana L; Yoluk O; Carrillo O; Orozco M; Lindahl E

Medarbetare och kontakt

Gruppledare

• 

  Laura Orellana Ramirez

  Senior Forskare

  E-postadress laura.orellana@ki.se

Alla medarbetare i gruppen

• 

  Mariia Feshyna

  Doktorand

  E-postadress mariia.feshyna@ki.se
• Johan Gustavsson

  Anknuten till Forskning

  E-postadress johan.gustavsson@ki.se
• 

  A. Najla Hosseini

  Forskningsassistent

  E-postadress najla.hosseini@ki.se
• 

  Byung Ho Lee

  Anknuten till Forskning

  E-postadress byung.ho.lee@ki.se
• Michael Nagy

  Doktorand

  E-postadress michael.nagy@ki.se
• Serena Gaetana Piticchio

  Anknuten till Forskning

  E-postadress serena.piticchio@ki.se
• Federico Pozzani

  Doktorand

  E-postadress federico.pozzani@ki.se
• 

  Domenico Scaramozzino

  Postdoktor

  E-postadress domenico.scaramozzino@ki.se