Laura Orellana

Om mig
Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Om mig

Jag är en strukturbiofysiker med medicinsk bakgrund. Mitt mål är att
förstå mänskliga sjukdomar i atomskala: hur mutationer förändrar
proteinstruktur, rörelser och biologisk funktion.
2021: Petrus och Augusta Hedlunds Foundation Grant
2021: Cancerfonden Junior Investigator Award
2020: Jeanssons Foundation Young Leaders Grant
2020: Karolinska Institute Research Foundation Special Grant
2019: Karolinska Institute Tenure-track Faculty Position with start-up grant
Award (KI Allocation of faculty funded career positions 2019 [1])
2019: O.E. och Edla Johanssons Research Grant
2016-2018: Sven och Lily Lawski Foundation Fellow
*Academic Honors*
2006: Extraordinary Prize for Academic Excellence in Biochemistry, University
of Barcelona
*2010–2014: PhD in Physics /summa cum laude/*/, /Faculty of Physics,
University of Barcelona
/Thesis: /“Protein Dynamics and Function studied by coarse-grained and
atomistic theoretical approaches” [2]
*2008–2011: Clinical training* (M.D. degree, 2nd cycle: 345 out of 500
ECTS), Hospital Clínic de Barcelona &
Hospital Universitari Sagrat Cor
*2008 –2010: MSc in Biophysics*, Faculty of Physics, University of
Barcelona
*2006 – 2007: MSc in Structure &
Function of Proteins*, Barcelona
Autonomous University
*2003–2005: BSc in Biochemistry with Extraordinary Prize &
minor in
Physics*, Faculty of Biology, University of Barcelona
*1999–2003: Medicine* (M.D. degree, 1st cycle), Faculty of Medicine,
University of Barcelona
*Academic appointments*
*Nov. 2020: Tenure-track Assistant Professor in Medical Sciences*,
Karolinska Institute
*2019-2020: Researcher (Forskare) in Structural Biology*, Stockholm
University
*2014-2018: Postdoctoral Fellow in Computational Biophysics &
Cryo-EM*,
Royal Institute of Technology (KTH) &
Stockholm University
*2008-2014: Graduate Student in Protein Biophysics &
Molecular
Modelling*, Institute for Research in Biomedicine in Barcelona &
Barcelona
Supercomputing Center
[1] https://ki.se/en/about/allocation-of-faculty-funded-career-positions-2019
[2] https://www.tdx.cat/handle/10803/283656

Forskningsbeskrivning

Min grupp utvecklar teoretiska metoder och algoritmer för att förutsäga
konformationsförändringar i proteiner och tillämpa dem på den fördjupade
integrativa studien av cancermutationer, i syfte att generera ny mekanistisk
hypotes och testa dem in vitro och in vivo.
För mer information, se vår officiella KI sidan: Protein Dynamics and
Cancer Lab [1]
En fullständig publikationslista finns på Google scholar
[2] och ResearchGate [3].
[1] https://ki.se/en/onkpat/research-team-laura-orellana-protein-dynamics-and-cancer-lab
[2] https://scholar.google.es/citations?hl=en&
amp
user=s9mwu04AAAAJ&
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view_op=list_works&
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authuser=1&
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sortby=pubdate
[3] https://www.researchgate.net/profile/Laura_Orellana2

Artiklar

Article: NPJ GENOMIC MEDICINE. 2023;8(1):39
Clinical, genetic and structural delineation of RPL13-related spondyloepimetaphyseal dysplasia suggest extra-ribosomal functions of eL13
Jacob P; Lindelof H; Rustad CF; Sutton VR; Moosa S; Udupa P; Hammarsjo A; Bhavani GS; Batkovskyte D; Tveten K; Dalal A; Horemuzova E; Nordgren A; Tham E; Shah H; Merckoll E; Orellana L; Nishimura G; Girisha KM; Grigelioniene G
Journal article: APPLIED SCIENCES. 2023;13(11):6756
Are Protein Shape-Encoded Lowest-Frequency Motions a Key Phenotype Selected by Evolution?
Orellana L
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(2):108-120
Structure, mechanism and lipid-mediated remodeling of the mammalian Na⁺/H⁺ exchanger NHA2
Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Robinson CV; Nomura N; Iwata S; Landreh M; Orellana L; Beckstein O; Drew D
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:890851
Exploring the Conformational Impact of Glycine Receptor TM1-2 Mutations Through Coarse-Grained Analysis and Atomistic Simulations
Mhashal AR; Yoluk O; Orellana L
Article: NATURE COMMUNICATIONS. 2021;12(1):1728
Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
Thulasingam M; Orellana L; Nji E; Ahmad S; Rinaldo-Matthis A; Haeggstrom JZ
Article: EMBO JOURNAL. 2020;39(24):e105908-4559
Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9
Winklemann I; Matsuoka R; Meier PF; Shutin D; Zhang C; Orellana L; Sexton R; Landreh M; Robinson CV; Beckstein O; Drew D
Article: NATURE. 2020;578(7794):321-325
The molecular basis for sugar import in malaria parasites
Qureshi AA; Suades A; Matsuoka R; Brock J; McComas SE; Nji E; Orellana L; Claesson M; Delemotte L; Drew D
Journal article: CANCER CELL. 2019;36(6):690-691
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair (vol 35, pg 504, 2019)
Ma J; Benitez JA; Li J; Miki S; de Albuquerque CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
Article: BIOINFORMATICS. 2019;35(18):3505-3507
eBDIMS server: protein transition pathways with ensemble analysis in 2D-motion spaces
Orellana L; Gustaysson J; Bergh C; Yoluk O; Lindahl E
Article: MOLECULAR & CELLULAR ONCOLOGY. 2019;6(5):e1630798
Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy
Orellana L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(20):10009-10018
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
Orellana L; Thorne AH; Lema R; Gustavsson J; Parisian AD; Hospital A; Cordeiro TN; Bernado P; Scott AM; Brun-Heath I; Lindahl E; Cavenee WK; Furnari FB; Orozco M
Journal article: CANCER CELL. 2019;35(5):816
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair (vol 35, pg 504, 2019)
Ma J; Benitez JA; Li J; Miki S; de Albuquerque CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
Article: CANCER CELL. 2019;35(3):504-518.e7
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
Ma J; Benite JA; Li J; Miki S; de Albuquerqu CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
Article: CANCER CELL. 2018;34(1):163-177.e7
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development
Binder ZA; Thorne AH; Bakas S; Wileyto EP; Bilello M; Akbari H; Rathore S; Ha SM; Zhang L; Ferguson CJ; Dahiya S; Bi WL; Reardon DA; Idbaih A; Felsberg J; Hentschel B; Weller M; Bagley SJ; Morrissette JJD; Nasrallah MP; Ma J; Zanca C; Scott AM; Orellana L; Davatzikos C; Furnari FB; O'Rourke DM
Article: NATURE COMMUNICATIONS. 2016;7:12575
Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations
Orellana L; Yoluk O; Carrillo O; Orozco M; Lindahl E
Article: NATURE COMMUNICATIONS. 2014;5:4070
Correlated motions are a fundamental property of β-sheets
Bryn Fenwick R; Orellana L; Esteban-Martin S; Orozco M; Salvatella X
Journal article: SCIENCE. 2013;342(6154):37
NextGen Speaks
Van der Ploeg MJ
Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2012;8(11):4707-4718
Finding Conformational Transition Pathways from Discrete Molecular Dynamics Simulations
Sfriso P; Emperador A; Orellana L; Hospital A; Lluis Gelpi J; Orozco M
Journal article: SCIENCE. 2012;336(6077):32-34
NextGen speaks.
Journal article: ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY. 2011;85:183-215
COARSE-GRAINED REPRESENTATION OF PROTEIN FLEXIBILITY. FOUNDATIONS, SUCCESSES, AND SHORTCOMINGS
Orozco M; Orellana L; Hospital A; Naganathan AN; Emperador A; Carrillo O; Gelpi JL
Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2010;6(9):2910-2923
Approaching Elastic Network Models to Molecular Dynamics Flexibility
Orellana L; Rueda M; Ferrer-Costa C; Ramon Lopez-Blanco J; Chacon P; Orozco M
Article: BIOINFORMATICS. 2009;25(13):1709-1710
FlexServ: an integrated tool for the analysis of protein flexibility
Camps J; Carrillo O; Emperador A; Orellana L; Hospital A; Rueda M; Cicin-Sain D; D'Abramo M; Lluis Gelpi J; Orozco M
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Alla övriga publikationer

Corrigendum: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2023;30(4):565
Structure, mechanism and lipid-mediated remodeling of the mammalian Na⁺/H⁺ exchanger NHA2 (vol 29, pg 108, 2022)
Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Robinson CV; Nomura N; Iwata S; Landreh M; Orellana L; Beckstein O; Drew D
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S206
Elucidating the conformational transitions of large proteins and protein complexes via an improved coarse-grained simulation algorithm
Scaramozzino D; Orellana L
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S193
A multiscale simulation approach to unravel cancerrelated mutation patterns on conformational landscapes
Lee BH; Orellana L
Book chapter: ADVANCES IN PROTEIN MOLECULAR AND STRUCTURAL BIOLOGY METHODS. 2022;p. 199-212
Chapter 13 Computational techniques to study protein dynamics and conformations
Mhashal A; Emperador A; Orellana L
Preprint: BIORXIV. 2021
Structure and lipid-mediated remodelling mechanism of the Na⁺/H⁺exchanger NHA2
Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Nomura N; Iwata S; Orellana L; Beckstein O; Drew D
Conference publication: BIOPHYSICAL JOURNAL. 2021;120(3):105A
Ion Binding to a Mammalian Sodium/Proton Exchanger Membrane Protein from Molecular Dynamics Simulations
Zhang C; Sexton R; Winkelmann I; Matsuoka R; Meier P; Shutin D; Orellana L; Landreh M; Robinson CV; Drew D; Beckstein O
Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):584A
Allosteric Gating Determinants in the Transmembrane Domain of Pentameric Ligand-Gated Ion Channels
Howard RJ; Zhuang Y; Heusser SA; Bergh CC; Rovsnik U; Orellana L; Lindahl E
Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):191A
Mapping pH-Dependent State Transitions of a Pentameric Ligand-gated Ion Channel through Markov State Modeling
Bergh C; Orellana L; Heusser SA; Howard RJ; Lindahl E
Conference publication: BIOPHYSICAL JOURNAL. 2019;116(3):395A-396A
Understanding the Conformational Dynamics of a Pentameric Ligand-Gated Ion Channel through Markov State Modeling
Bergh CC; Orellana L; Howard RJ; Lindahl E
Conference publication: BIOPHYSICAL JOURNAL. 2019;116(3):245A-246A
Allosteric Modulation via Transmembrane Interfaces in a Pentameric Ligand-Gated Ion Channel
Howard RJ; Zhuang Y; Nakamura S; Lycksell M; Kiik H; Rovsnik U; Bergh C; Heusser SA; Orellana L; Lindahl E
Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2019;6:117
Large-Scale Conformational Changes and Protein Function: Breaking the in silico Barrier
Orellana L
Conference publication: BIOPHYSICAL JOURNAL. 2017;112(3):485A
Trapping On-Pathway Intermediates for Large Scale Conformational Changes with Coarse-Grained Simulations
Orellana L; Yoluk O; Carrillo O; Orozco M; Lindahl E
Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):54A
Revealing the Mechanism for Conformational Changes from Structurally Rich Ensembles
Orellana L; Yoluk O; Orozco M; Lindahl E
Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):454A
Principal Components from Ligand-Gated Ion Channel Structures Enable Ensemble Studies of Microsecond-Scale Transitions
Yoluk O; Orellana L; Bertaccini EJ; Trudell JR; Lindahl E
Conference publication: NEURO-ONCOLOGY. 2016;18:45
MUTATIONAL HETEROGENEITY OF THE EGFR EXTRACELLULAR DOMAIN PROMOTES AN ONCOGENIC UNTETHERED TRANSITIONAL CONFORMATION AND THE POTENTIAL FOR GREATER THERAPEUTIC TARGETING IN GBM PATIENTS
Thorne AH; Orellana L; Parisian A; Cavenee W; Furnari F
Preprint: BIORXIV. 2014
Oncogenic mutations of the EGF-Receptor ectodomain reveal an unexpected mechanism for ligand-independent activation
ORELLANA LAURA; HOSPITAL ADAM; OROZCO MODESTO

Forskningsbidrag

Discovering conformational convergence in cancer proteins through computer simulations and experiments
Swedish Research Council
1 January 2022 - 31 December 2025

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