Laura Orellana
Biträdande Lektor
E-postadress: laura.orellana@ki.se
Besöksadress: BioClinicum - J6:06, Akademiska Stråket 1, 17164 Solna
Postadress: K7 Onkologi-Patologi, K7 Forskning Orellana, 171 77 Stockholm
Om mig
- Jag är en strukturbiofysiker med medicinsk bakgrund. Mitt mål är att
förstå mänskliga sjukdomar i atomskala: hur mutationer förändrar
proteinstruktur, rörelser och biologisk funktion.
2021: Petrus och Augusta Hedlunds Foundation Grant
2021: Cancerfonden Junior Investigator Award
2020: Jeanssons Foundation Young Leaders Grant
2020: Karolinska Institute Research Foundation Special Grant
2019: Karolinska Institute Tenure-track Faculty Position with start-up grant
Award (KI Allocation of faculty funded career positions 2019 [1])
2019: O.E. och Edla Johanssons Research Grant
2016-2018: Sven och Lily Lawski Foundation Fellow
*Academic Honors*
2006: Extraordinary Prize for Academic Excellence in Biochemistry, University
of Barcelona
*2010–2014: PhD in Physics /summa cum laude/*/, /Faculty of Physics,
University of Barcelona
/Thesis: /“Protein Dynamics and Function studied by coarse-grained and
atomistic theoretical approaches” [2]
*2008–2011: Clinical training* (M.D. degree, 2nd cycle: 345 out of 500
ECTS), Hospital Clínic de Barcelona & Hospital Universitari Sagrat Cor
*2008 –2010: MSc in Biophysics*, Faculty of Physics, University of
Barcelona
*2006 – 2007: MSc in Structure & Function of Proteins*, Barcelona
Autonomous University
*2003–2005: BSc in Biochemistry with Extraordinary Prize & minor in
Physics*, Faculty of Biology, University of Barcelona
*1999–2003: Medicine* (M.D. degree, 1st cycle), Faculty of Medicine,
University of Barcelona
*Academic appointments*
*Nov. 2020: Tenure-track Assistant Professor in Medical Sciences*,
Karolinska Institute
*2019-2020: Researcher (Forskare) in Structural Biology*, Stockholm
University
*2014-2018: Postdoctoral Fellow in Computational Biophysics & Cryo-EM*,
Royal Institute of Technology (KTH) & Stockholm University
*2008-2014: Graduate Student in Protein Biophysics & Molecular
Modelling*, Institute for Research in Biomedicine in Barcelona & Barcelona
Supercomputing Center
[1] https://ki.se/en/about/allocation-of-faculty-funded-career-positions-2019
[2] https://www.tdx.cat/handle/10803/283656
Forskningsbeskrivning
- Min grupp utvecklar teoretiska metoder och algoritmer för att förutsäga
konformationsförändringar i proteiner och tillämpa dem på den fördjupade
integrativa studien av cancermutationer, i syfte att generera ny mekanistisk
hypotes och testa dem in vitro och in vivo.
För mer information, se vår officiella KI sidan: Protein Dynamics and
Cancer Lab [1]
En fullständig publikationslista finns på Google scholar
[2] och ResearchGate [3].
[1] https://ki.se/en/onkpat/research-team-laura-orellana-protein-dynamics-and-cancer-lab
[2] https://scholar.google.es/citations?hl=en&;amp;user=s9mwu04AAAAJ&view_op=list_works&authuser=1&sortby=pubdate
[3] https://www.researchgate.net/profile/Laura_Orellana2
Artiklar
- Journal article: JOURNAL OF MOLECULAR BIOLOGY. 2025;437(24):169493Orellana L
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2025;33(11):1474-1483Lindelof H; Hammarsjo A; Voss U; Piticchio SG; Conner P; Papadogiannakis N; Batkovskyte D; Orellana L; Kvarnung M; Malmgren H; Robinson KL; Nordgren A; Lindstrand A; Nishimura G; Grigelioniene G
- Article: NPJ GENOMIC MEDICINE. 2023;8(1):39Jacob P; Lindelof H; Rustad CF; Sutton VR; Moosa S; Udupa P; Hammarsjo A; Bhavani GS; Batkovskyte D; Tveten K; Dalal A; Horemuzova E; Nordgren A; Tham E; Shah H; Merckoll E; Orellana L; Nishimura G; Girisha KM; Grigelioniene G
- Journal article: APPLIED SCIENCES-BASEL. 2023;13(11):6756Orellana L
- Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:890851Mhashal AR; Yoluk O; Orellana L
- Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(2):108-120Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Robinson CV; Nomura N; Iwata S; Landreh M; Orellana L; Beckstein O; Drew D
- Article: NATURE COMMUNICATIONS. 2021;12(1):1728Thulasingam M; Orellana L; Nji E; Ahmad S; Rinaldo-Matthis A; Haeggstrom JZ
- Article: EMBO JOURNAL. 2020;39(24):e105908-4559Winklemann I; Matsuoka R; Meier PF; Shutin D; Zhang C; Orellana L; Sexton R; Landreh M; Robinson CV; Beckstein O; Drew D
- Article: NATURE. 2020;578(7794):321-325Qureshi AA; Suades A; Matsuoka R; Brock J; McComas SE; Nji E; Orellana L; Claesson M; Delemotte L; Drew D
- Journal article: CANCER CELL. 2019;36(6):690-691Ma J; Benitez JA; Li J; Miki S; de Albuquerque CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
- Article: BIOINFORMATICS. 2019;35(18):3505-3507Orellana L; Gustaysson J; Bergh C; Yoluk O; Lindahl E
- Article: MOLECULAR & CELLULAR ONCOLOGY. 2019;6(5):e1630798Orellana L
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(20):10009-10018Orellana L; Thorne AH; Lema R; Gustavsson J; Parisian AD; Hospital A; Cordeiro TN; Bernado P; Scott AM; Brun-Heath I; Lindahl E; Cavenee WK; Furnari FB; Orozco M
- Journal article: CANCER CELL. 2019;35(5):816Ma J; Benitez JA; Li J; Miki S; de Albuquerque CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
- Article: CANCER CELL. 2019;35(3):504-518.e7Ma J; Benite JA; Li J; Miki S; de Albuquerqu CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
- Article: CANCER CELL. 2018;34(1):163-177.e7Binder ZA; Thorne AH; Bakas S; Wileyto EP; Bilello M; Akbari H; Rathore S; Ha SM; Zhang L; Ferguson CJ; Dahiya S; Bi WL; Reardon DA; Idbaih A; Felsberg J; Hentschel B; Weller M; Bagley SJ; Morrissette JJD; Nasrallah MP; Ma J; Zanca C; Scott AM; Orellana L; Davatzikos C; Furnari FB; O'Rourke DM
- Article: NATURE COMMUNICATIONS. 2016;7:12575Orellana L; Yoluk O; Carrillo O; Orozco M; Lindahl E
- Article: NATURE COMMUNICATIONS. 2014;5:4070Bryn Fenwick R; Orellana L; Esteban-Martin S; Orozco M; Salvatella X
- Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2012;8(11):4707-4718Sfriso P; Emperador A; Orellana L; Hospital A; Lluis Gelpi J; Orozco M
- Journal article: SCIENCE. 2012;336(6077):32-34
- Journal article: ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 123: TRANSPORT PROTEINS. 2011;85:183-215Orozco M; Orellana L; Hospital A; Naganathan AN; Emperador A; Carrillo O; Gelpi JL
- Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2010;6(9):2910-2923Orellana L; Rueda M; Ferrer-Costa C; Ramon Lopez-Blanco J; Chacon P; Orozco M
- Article: BIOINFORMATICS. 2009;25(13):1709-1710Camps J; Carrillo O; Emperador A; Orellana L; Hospital A; Rueda M; Cicin-Sain D; D'Abramo M; Lluis Gelpi J; Orozco M
- Visa fler
Alla övriga publikationer
- Preprint: BIORXIV. 2025Teder T; Pozzani F; Schulte T; Hosseini AN; Rådmark O; Orellana L; Haeggström JZ
- Preprint: RESEARCH SQUARE. 2025Orellana L; Scaramozzino D; Lee BH
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S206Scaramozzino D; Orellana L
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S193Lee BH; Orellana L
- Corrigendum: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2023;30(4):565Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Robinson CV; Nomura N; Iwata S; Landreh M; Orellana L; Beckstein O; Drew D
- Book chapter: ADVANCES IN PROTEIN MOLECULAR AND STRUCTURAL BIOLOGY METHODS. 2022;p. 199-212Mhashal A; Emperador A; Orellana L
- Preprint: BIORXIV. 2021Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Nomura N; Iwata S; Orellana L; Beckstein O; Drew D
- Conference publication: BIOPHYSICAL JOURNAL. 2021;120(3):105AZhang C; Sexton R; Winkelmann I; Matsuoka R; Meier P; Shutin D; Orellana L; Landreh M; Robinson CV; Drew D; Beckstein O
- Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):584AHoward RJ; Zhuang Y; Heusser SA; Bergh CC; Rovsnik U; Orellana L; Lindahl E
- Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):191ABergh C; Orellana L; Heusser SA; Howard RJ; Lindahl E
- Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2019;6:117Orellana L
- Conference publication: BIOPHYSICAL JOURNAL. 2019;116(3):395A-396ABergh CC; Orellana L; Howard RJ; Lindahl E
- Conference publication: BIOPHYSICAL JOURNAL. 2019;116(3):245A-246AHoward RJ; Zhuang Y; Nakamura S; Lycksell M; Kiik H; Rovsnik U; Bergh C; Heusser SA; Orellana L; Lindahl E
- Conference publication: BIOPHYSICAL JOURNAL. 2017;112(3):485AOrellana L; Yoluk O; Carrillo O; Orozco M; Lindahl E
- Conference publication: NEURO-ONCOLOGY. 2016;18:45Thorne AH; Orellana L; Parisian A; Cavenee W; Furnari F
- Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):454AYoluk O; Orellana L; Bertaccini EJ; Trudell JR; Lindahl E
- Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):54AOrellana L; Yoluk O; Orozco M; Lindahl E
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2015;44:S219Yoluk O; Orellana L; Lindahl E
- Conference publication: BIOPHYSICAL JOURNAL. 2015;108(2):431AYoluk O; Heusser S; Andersson M; Orellana L; Lindahl E
- Preprint: BIORXIV. 2014ORELLANA LAURA; HOSPITAL ADAM; OROZCO MODESTO
Forskningsbidrag
- Swedish Research Council1 January 2022 - 31 December 2025