Translationell bröstcancerforskning: långsiktig risk och endokrin behandlingsnytta – Linda Lindströms forskargrupp

Vi bedriver tvärvetenskaplig forskning om bröstcancer, med särskilt intresse av långsiktig risk, intratumör heterogenitet och tumör-mikromiljö. En unik egenskap för hormondriven bröstcancer, östrogenreceptor-positiv (ER+), är den långsiktiga risken för metastatisk sjukdom, ibland decennier efter initial diagnos. Vår forskning syftar till att förstå sjukdomsmekanismerna bakom långsiktig risk med mål att kunna individanpassa behandlingsstrategier och information till kvinnor med ER+ bröstcancer.

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Institutionen för onkologi-patologi

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Publikationer

Utvalda publikationer

Article: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(35):4071-4082
Twenty-Year Benefit From Adjuvant Goserelin and Tamoxifen in Premenopausal Patients With Breast Cancer in a Controlled Randomized Clinical Trial
Johansson A; Dar H; Veer LJVT; Tobin NP; Perez-Tenorio G; Nordenskjold A; Johansson U; Hartman J; Skoog L; Yau C; Benz CC; Esserman LJ; Stal O; Nordenskjold B; Fornander T; Lindstrom LS
Article: JAMA NETWORK OPEN. 2021;4(6):e2114904
Assessment of 25-Year Survival of Women With Estrogen Receptor-Positive/ERBB2-Negative Breast Cancer Treated With and Without Tamoxifen Therapy A Secondary Analysis of Data From the Stockholm Tamoxifen Randomized Clinical Trial
Dar H; Johansson A; Nordenskjold A; Iftimi A; Yau C; Perez-Tenorio G; Benz C; Nordenskjold B; Stal O; Esserman LJ; Fornander T; Lindstrom LS
Article: JAMA NETWORK OPEN. 2021;4(6):e2114716
Characterization of Benign Breast Diseases and Association With Age, Hormonal Factors, and Family History of Breast Cancer Among Women in Sweden
Johansson A; Christakou AE; Iftimi A; Eriksson M; Tapia J; Skoog L; Benz CC; Rodriguez-Wallberg KA; Hall P; Czene K; Lindstrom LS
Article: JAMA ONCOLOGY. 2019;5(9):1304-1309
Assessment of Long-term Distant Recurrence-Free Survival Associated With Tamoxifen Therapy in Postmenopausal Patients With Luminal A or Luminal B Breast Cancer
Yu NY; Iftimi A; Yau C; Tobin NP; van 't Veer L; Hoadley KA; Benz CC; Nordenskjold B; Fornander T; Stal O; Czene K; Esserman LJ; Lindstrom LS
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2018;110(7):726-733
Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer
Lindstrom LS; Yau C; Czene K; Thompson CK; Hoadley KA; van't Veer LJ; Balassanian R; Bishop JW; Carpenter PM; Chen Y-Y; Datnow B; Hasteh F; Krings G; Lin F; Zhang Y; Nordenskjold B; Stal O; Benz CC; Fornander T; Borowsky AD; Esserman LJ
Article: JAMA ONCOLOGY. 2017;3(11):1503-1510
Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades
Esserman LJ; Yau C; Thompson CK; van't Veer LJ; Borowsky AD; Hoadley KA; Tobin NP; Nordenskjold B; Fornander T; Stal O; Benz CC; Lindstrom LS
Article: ANNALS OF ONCOLOGY. 2015;26(1):81-88
Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival
Tobin NP; Harrell JC; Lövrot J; Egyhazi Brage S; Frostvik Stolt M; Carlsson L; Einbeigi Z; Linderholm B; Loman N; Malmberg M; Walz T; Fernö M; Perou CM; Bergh J; Hatschek T; Lindström LS
Article: ANNALS OF ONCOLOGY. 2014;25(10):1966-1972
Prognostic information of a previously diagnosed sister is an independent prognosticator for a newly diagnosed sister with breast cancer
Lindstrom LS; Li J; Lee M; Einbeigi Z; Hartman M; Hall P; Czene K
Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(21):2601-2608
Clinically Used Breast Cancer Markers Such As Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Are Unstable Throughout Tumor Progression
Lindstrom LS; Karlsson E; Wilking UM; Johansson U; Hartman J; Lidbrink EK; Hatschek T; Skoog L; Bergh J
Article: LANCET ONCOLOGY. 2007;8(11):1001-1006
Familial concordance in cancer survival:: a Swedish population-based study
Lindstrom LS; Hall P; Hartman M; Wiklund F; Gronberg H; Czene K

Medarbetare och kontakt

Gruppledare

Linda Sofie Lindström
Senior Forskare | Docent
Telefon +46852488117
E-postadress linda.lindstrom@ki.se

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Elin Backman Stålnacke
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E-postadress elin.backman.stalnacke@ki.se
Paula Camargo Romera
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Regina Crespo Lopez Oliver
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Oscar Danielsson
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Tommy Fornander
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Elham Hedayati
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E-postadress elham.hedayati@ki.se
Annelie Johansson
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Aina Johnsson
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E-postadress aina.johnsson@ki.se
Rebecka Keijser
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Annelie Liljegren
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E-postadress annelie.liljegren@ki.se
Lorenzo Mancuso
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E-postadress lorenzo.mancuso@ki.se
Melissa Penna
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E-postadress melissa.penna@ki.se
Iurii Petrov
Postdoktorala Studier | Doktorand
E-postadress iurii.petrov@ki.se
Kankana Roy
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Per Rydberg
Forskningsspecialist
E-postadress per.rydberg@ki.se
Magdalena Ríos Romero
Anknuten till Forskning
E-postadress magdalena.rios.romero@ki.se
Hira Shahid
Forskningsassistent
E-postadress hira.shahid@ki.se
Jacob Thurell
Doktorand
E-postadress jacob.thurell@ki.se
Nicholas Tobin
Adjunkt | Senior Forskare | Docent
E-postadress nick.tobin@ki.se
Julia Tutzauer
Postdoktor
E-postadress julia.tutzauer@ki.se
Jo Kurt J de Vos
Doktorand
E-postadress jo.de.vos@ki.se