Functional Precision Medicine – Brinton Seashore-Ludlow's Team

Publications

All publications from group members

Journal article: ISCIENCE. 2026;29(8):116673
A host-centric morphological profiling approach to identify repurposed antiviral drugs
Asp E; Rietdijk J; Tampere M; Axelsson H; Njenda D; Potdar S; Kalman A; Georgieva P; Lapins M; Ballante F; Soler A; de Kort M; Aittokallio T; Zaliani A; Kuzikov M; Gribbon P; Lo D; Carreras-Puigvert J; Seashore-Ludlow B; Spjuth O; Stling P
Journal article: NPJ PRECISION ONCOLOGY. 2026;10(1):301
Functional profiling of ovarian cancer models reveals Bcl-xL/NOTCH targeting to overcome resistance
Gudoityte G; Berkovska O; Orre LM; Moussaud-Lamodiere E; Bergstrom R; Lindberg J; Haraldsson M; Nafeh SB; Louhaur M; Kallioniemi O; Fernebro J; Joneborg U; Seashore-Ludlow B
Article: BIOMEDICINE & PHARMACOTHERAPY. 2026;200:119575
Standardized workflow enables reproducibility of drug synergism detection: Results from a multi-center in vitro ring test on complex drug combinations in pancreatic cancer models.
Barile V; Kuzikov M; Cui W; Ianevski A; Iannelli F; Roca MS; Reinshagen J; Axelsson H; Leone A; Jenmalm Jensen A; Aittokallio T; Gribbon P; Seashore-Ludlow B; Budillon A
Article: STAR PROTOCOLS. 2026;7(2):104480
Protocol for culture, drug treatment, and dissociation of patient-derived 3D ovarian cancer microspheroids for flow cytometry
Haffa M; Juhani K; Gudoityte G; Otvos RH-G; Wallin E; Kallioniemi O-P; Fernebro J; Joneborg U; Seashore-Ludlow B
Article: PATTERNS. 2026;7(4):101453
Experimental and machine learning-based exploration of repurposed drugs reveals chemical features underlying phospholipidosis
Kuzikov M; Kalman A; Karki R; Reinshagen J; Huchting J; Qian K; Axelsson H; Tampere M; Ostling P; Seashore-Ludlow B; Gadiya Y; Gribbon P; Zaliani A
Article: NPJ PRECISION ONCOLOGY. 2026;10(1):117
Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics
Struyf N; Gezelius H; Lundmark A; Barizza C; Ploeger H; Rico Pizarro L; Vesterlund M; Mermelekas G; Osterroos A; Bohlin A; Bengtzen S; Hamberg Levedahl K; Jafari R; Orre LM; Lehtio J; Ostling P; Seashore-Ludlow B; Nordlund J; Lehmann S; Kallioniemi O; Erkers T
Doctoral thesis: 2026
Integrative analysis of morphological and chemical signatures for understanding drug perturbations in diverse cancer cell models
Sharma O
Doctoral thesis: 2025
Functional precision medicine approaches to identify novel therapeutic strategies in ovarian cancer
Gudoityte G
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2025;102(4):e70055
Cross-Sectional and Longitudinal Immunoprofiling of Oligoarticular Juvenile Idiopathic Arthritis Reveals Different Patterns in Synovial Fluid and Plasma
Qu H; Neog M; Palmblad K; Sundberg E; Lovquist A; Melen E; Aulin C; Harris HE
Article: BIOMEDICINE & PHARMACOTHERAPY. 2025;191:118447
Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing.
Tampere M; H Le T; Asp E; Kalman A; Kaimal JM; Njenda D; Bäckström A; Axelsson U; Xu H; Ouyang W; Axelsson H; Marabita F; Moussaud-Lamodière E; Sepulveda CO; Seashore-Ludlow B; Vernersson C; Mirazimi A; Lundberg E; Östling P; Stadler C
Article: MOLECULAR ONCOLOGY. 2025;19(9):2574-2593
Systematic profiling of cancer-fibroblast interactions reveals drug combinations in ovarian cancer
Gudoityte G; Sharma O; Leuenberger L; Wallin E; Fernebro J; Ostling P; Bergstroem R; Lindberg J; Joneborg U; Kallioniemi O; Seashore-Ludlow B
Article: FRONTIERS IN IMMUNOLOGY. 2025;16:1599747
Inflammation-profiling reveals activated pathways and biomarkers with predictive potential in oligoarticular juvenile idiopathic arthritis
Wen X; Aulin C; Sundberg E; Qu H; Struglics A; Merritt A-S; Melen E; Altman M; Harris HE
Article: CANCERS. 2025;17(14):2363
Ex Vivo Drug Sensitivity of Pleural Effusion-Derived Cells from Lung Cancer and Pleural Mesothelioma Patients Is Linked to Clinical Response
Hutyra-Gram Otvos R; Krynska H; Gudoityte G; Skribek M; Oniscu A; Berkovska O; Strauss K; Zipprick J; Tamborero D; Alexeyenko A; Gad AKB; Seashore-Ludlow B; Dobra K
Journal article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2025;44(1):199
PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy
Prokarenkaite R; Kuodyte K; Gudoityte G; Budginaite E; Naumovas D; Strainiene E; Velickevicius K; Dulskas A; Sileika E; Venius J; Tunaitis V; Pivoriunas A; Starkuviene V; Stankevicius V; Suziedelis K
Review: NATURE REVIEWS DRUG DISCOVERY. 2025;24(7):521-542
Computational drug repurposing: approaches, evaluation of in silico resources and case studies
Tanoli Z; Fernandez-Torras A; Ozcan UO; Kushnir A; Nader KM; Gadiya Y; Fiorenza L; Ianevski A; Vaha-Koskela M; Miihkinen M; Seemab U; Leinonen H; Seashore-Ludlow B; Tampere M; Kalman A; Ballante F; Benfenati E; Saunders G; Potdar S; Garcia IG; Garcia-Serna R; Talarico C; Beccari AR; Schaal W; Polo A; Costantini S; Cabri E; Jacobs M; Saarela J; Budillon A; Spjuth O; Ostling P; Xhaard H; Quintana J; Mestres J; Gribbon P; Ussi AE; Lo DC; de Kort M; Wennerberg K; Fratelli M; Carreras-Puigvert J; Aittokallio T
Journal article: 2025
High Content Imaging in Drug Discovery
Editor(s): Pilling J; Carragher N
Book chapter: HIGH CONTENT IMAGING IN DRUG DISCOVERY. 2025;p. 168-208
High Content Imaging Applications of Advanced and Translational Disease Models in Drug Discovery and Development
Cui W; Haffa M; Massai F; Qian K; Vallin M; Axelsson H; Seashore-Ludlow B
Article: CELL DEATH & DISEASE. 2025;16(1):318
Targeted inhibition of WIP1 and histone H3K27 demethylase activity synergistically suppresses neuroblastoma growth
Treis D; Lundberg KI; Bell N; Polychronopoulos PA; Tuemmler C; Akerlund E; Aliverti S; Lilienthal I; Pepich A; Seashore-Ludlow B; Sakaguchi K; Kogner P; Johnsen JI; Wickstroem M
Journal article: LANCET. 2025;405(10482):927-936
Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial
Veltkamp R; Korompoki E; Harvey KH; Harvey ER; Fiessler C; Malzahn U; Montaner J; Caso V; Sibon I; Ringleb P; Halse O; Ullmann S; Schuhmann C; Todd GP; Haas K; Lachaize M; D'Aoust T; Enzinger C; Ropele S; Fandler-Hoefler S; Haidegger M; Wang Y; Wafa HA; Cancelloni V; Mosconi MG; Lip GYH; Lane DA; Haefeli WE; Foerster I; Wurmbach VS; Nielsen PB; Hajjar K; Mueller P; Poli S; Purrucker J; Laible M; D'Anna L; Silva Y; Chacon RDT; Martinez-Sanchez P; Boulanger M; Norrving B; Pare G; Wachter R; Ntaios G; Wolfe CDA; Heuschmann PU
Journal article: CANCER RESEARCH. 2025;85(5):b026
Leveraging patient-derived models to identify novel treatment options in high-grade serous ovarian cancer
Gudoityte G; Berkovska O; Orre L; Moussaud-Lemoderie E; Fernebro J; Joneborg U; Kallioniemi O; Seashore-Ludlow B
Meeting abstract: CANCER RESEARCH. 2025;85(5):a017
Enhanced efficacy of anti-mesothelin CAR T cells in ovarian cancer through drug combinations: Impact of treatment kinetics, co-stimulatory domain, and donor variability
Pizarro LR; Poiret T; Gudoityte G; Kallioniemi O; Seashore-Ludlow B; Magalhaes I; Erkers T
Article: COMMUNICATIONS BIOLOGY. 2025;8(1):303
Evaluating feature extraction in ovarian cancer cell line co-cultures using deep neural networks
Sharma O; Gudoityte G; Minozada R; Kallioniemi OP; Turkki R; Paavolainen L; Seashore-Ludlow B
Article: ISCIENCE. 2025;28(2):111864
Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer
Pan Y; Berkovska O; Marathe S; Mermelekas G; Gudoityte G; Wolide AD; Arslan T; Seashore-Ludlow B; Lehtio J; Orre LM
Journal article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2025;35(2):101462
Tumor-Associated Macrophages Improve The Efficacy Of SMAC Mimetics Combined With Chemotherapy In Ovarian Cancer
Coelho R; Seashore-Ludlow B; Schutz S; Lombardo FC; Schmid V; Alflen L; Zwimpfer TA; Hensler M; Fedier A; Fucikova J; Kallioniemi O; David L; Heinzelmann-Schwarz V; Jacob. F
Article: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION. 2025;2025:baaf081
From library to landscape: integrative annotation workflows for compound libraries in drug repurposing
Reinshagen J; Seashore-Ludlow B; Gadiya Y; Gustavsson A-L; Tanoli Z; Aittokallio T; Huchting J; Jenmalm-Jensen A; Gribbon P; Zaliani A; Ballante F
Dataset: KI DATA REPOSITORY. 2025
Evaluating Feature Extraction in Ovarian Cancer Cell Line Co-Cultures Using Deep Neural Networks
Sharma O; Seashore-Ludlow B
Article: ADVANCED SCIENCE. 2025;12(3):e2407572
Chemogenomic Screening in a Patient-Derived 3D Fatty Liver Disease Model Reveals the CHRM1-TRPM8 Axis as a Novel Module for Targeted Intervention
Youhanna S; Kemas AM; Wright SC; Zhong Y; Klumpp B; Klein K; Motso A; Michel M; Ziegler N; Shang M; Sabatier P; Kannt A; Sheng H; Oliva-Vilarnau N; Buettner FA; Seashore-Ludlow B; Schreiner J; Windbergs M; Cornillet M; Bjorkstrom NK; Hulsmeier AJ; Hornemann T; Olsen JV; Wang Y; Gramignoli R; Sundstrom M; Lauschke VM
Article: CANCER LETTERS. 2024;605:217261
The ROCK-1/2 inhibitor RKI-1447 blocks N-MYC, promotes cell death, and emerges as a synergistic partner for BET inhibitors in neuroblastoma
Pepich A; Tummler C; Abu Ajamieh S; Treis D; Boje AS; Vellema Q; Tsea I; Akerlund E; Seashore-Ludlow B; Fard SS; Kogner P; Johnsen JI; Wickstrom M
Review: MED. 2024;5(11):1351-1377
Patient-derived organoids in precision cancer medicine
Tong L; Cui W; Zhang B; Fonseca P; Zhao Q; Zhang P; Xu B; Zhang Q; Li Z; Seashore-Ludlow B; Yang Y; Si L; Lundqvist A
Journal article: BLOOD. 2024;144:1565
Resistance to FLT3 Inhibitors in FLT3-Mutated AML Is Associated with CD45RA+CD200-leukemic Cells and Can be Overcome By Combination with SMAC Mimetics
Struyf N; Gezelius H; Lundmark A; Barizza C; Ploeger H; Pizarro LR; Uesterlund M; Mermelekas G; Osterroos A; Bohlin A; Bengtzen S; Levedahl KH; Jafari R; Orre LM; Lehtio J; Ostling P; Seashore-Ludlow B; Nordlund J; Lehmann S; Kallioniemi O; Erkers T
Article: CELL DEATH & DISEASE. 2024;15(9):694
SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis
Murga M; Lopez-Pernas G; Soliva R; Fueyo-Marcos E; Amor C; Faustino I; Serna M; Serrano AG; Diaz L; Martinez S; Blanco-Aparicio C; Anton ME; Seashore-Ludlow B; Pastor J; Jafari R; Lafarga M; Llorca O; Orozco M; Fernandez-Capetillo O
Preprint: BIORXIV. 2024;BIORXIV
Compound models and Pearson residuals for single-cell RNA-seq data without UMIs.
Lause J; Ziegenhain C; Hartmanis L; Berens P; Kobak D
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2024;43(1):107
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
Article: ONCOGENE. 2024;43(15):1113-1126
Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independence
Reid SE; Pantaleo J; Bolivar P; Bocci M; Sjolund J; Morsing M; Cordero E; Larsson S; Malmberg M; Seashore-Ludlow B; Pietras K
Journal article: CANCER RESEARCH. 2024;84(6):3100
Interactive analysis of drug testing data for functional precision oncology with Breeze 2.0
Potdar S; Ianevski F; Ianevski A; Tanoli Z; Wennerberg K; Seashore-Ludlow B; Kallioniemi O; Ostling P; Aittokallio T; Saarela J
Journal article: CANCER RESEARCH. 2024;84(6):706
Advancing radiotherapy strategies for high-risk rhabdomyosarcoma: Unveiling BCLxL inhibition as a potent sensitizer to radiotherapy
Park SSW; Struyf N; Erkers T; Lehmann S; Meister MT; Drost J; Holstege FC; Herold N; Ostling P; Stenman J; Kallioniemi O; Henter J-I; Seashore-Ludlow B; Karlsson K
Journal article: CANCER RESEARCH. 2024;84(6):4727
Large scale drug response comparison across different neuroblastoma cell model systems
Park SW; Liu E; Los A; Seashore-Ludlow B; Ostling P; Molenaar J; Kallioniemi O; Stenman J; Karlsson K
Journal article: LANCET REGIONAL HEALTH-EUROPE. 2024;38:100842
Burden of intracerebral haemorrhage in Europe: forecasting incidence and mortality between 2019 and 2050
Wafa HA; Marshall I; Wolfe CDA; Xie W; Johnson CO; Veltkamp R; Wang Y
Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Struyf N; Osterroos A; Vesterlund M; Arnroth C; James T; Sunandar S; Mermelekas G; Bohlin A; Hamberg Levedahl K; Bengtzen S; Jafari R; Orre LM; Lehtio J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B; Erkers T
Article: SCIENTIFIC REPORTS. 2024;14(1):4000
Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia
Bwanika HC; Leo IR; Struyf N; Talanti A; Aswad L; Konnur A; Bjoerklund A-C; Heyman M; Rassidakis G; Erkers T; Seashore-Ludlow B; Jafari R; Pokrovskaja Tamm K
Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335
High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance
Zaghmi A; Aybay E; Jiang L; Shang M; Steinmetz-Spah J; Wermeling F; Kogner P; Korotkova M; Ostling P; Jakobsson P-J; Seashore-Ludlow B; Larsson K
Article: SLAS TECHNOLOGY. 2023;28(6):423-432
High-throughput cell spheroid production and assembly analysis by microfluidics and deep learning
Trossbach M; Akerlund E; Langer K; Seashore-Ludlow B; Joensson HN
Article: NPJ PRECISION ONCOLOGY. 2023;7(1):111
The drug efficacy testing in 3D cultures platform identifies effective drugs for ovarian cancer patients.
Åkerlund E; Gudoityte G; Moussaud-Lamodière E; Lind O; Bwanika HC; Lehti K; Salehi S; Carlson J; Wallin E; Fernebro J; Östling P; Kallioniemi O; Joneborg U; Seashore-Ludlow B
Article: NUCLEIC ACIDS RESEARCH. 2023;51(W1):W57-W61
Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data
Potdar S; Ianevski F; Ianevski A; Tanoli Z; Wennerberg K; Seashore-Ludlow B; Kallioniemi O; Ostling P; Aittokallio T; Saarela J
Journal article: NATURE PROTOCOLS. 2023;18(7):1981-2013
Optimizing the Cell Painting assay for image-based profiling
Cimini BA; Chandrasekaran SN; Kost-Alimova M; Miller L; Goodale A; Fritchman B; Byrne P; Garg S; Jamali N; Logan DJ; Concannon JB; Lardeau C-H; Mouchet E; Singh S; Abbasi HS; Aspesi JP; Boyd JD; Gilbert T; Gnutt D; Hariharan S; Hernandez D; Hormel G; Juhani K; Melanson M; Mervin LH; Monteverde T; Pilling JE; Skepner A; Swalley SE; Vrcic A; Weisbart E; Williams G; Yu S; Zapiec B; Carpenter AE
Preprint: RESEARCH SQUARE. 2023
The Drug Efficacy Testing in Ex Vivo 3D Cultures (DETECt) platform enables rapid identification of effective drugs and drug combinations for ovarian cancer patients
Seashore-Ludlow B; Åkerlund E; Gudoityte G; Moussaud-Lamodière E; Lind O; Bwanika HC; Lehti K; Saheli S; Carlson J; Wallin E; Fernebro J; Ostling P; Kallioniemi O; Joneborg U
Journal article: CANCER RESEARCH. 2023;83(7):6612
Data-driven hallmarks of cancer as a new paradigm for precision medicine: multi-omics and functional profiling in acute myeloid leukemia
Erkers T; Struyf N; James T; Marabita F; Vesterlund M; Vu N; Arnroth C; Osterroos A; Bohlin A; Bengtzen S; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
Meeting abstract: CANCER RESEARCH. 2023;83(7):4578
Miniaturized and multiplexed evaluation of NK cell cytotoxicity and infiltration in patient-derived sarcoma spheroids using a novel multichambered microwell chip
Carannante V; Sandstrom N; Olofsson K; Neo SY; Sandoz PA; Van Ooijen H; Verron Q; Fontana J; Toullec D; Moussaud-Lamodiere E; Seashore-Ludlow B; Frisk T; Takai M; Ostling P; Haglund F; Lundqvist A; Wiklund M; Onfelt B
Doctoral thesis: 2023
Studies of the immunopathogenesis of arthritis, with an emphasis on the alarmin HMGB1
Qu H
Doctoral thesis: 2023
Studies on genetic and epigenetic regulation of gene expression dynamics
Hartmanis L
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(6):925-940
Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial
Jadersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzen S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Ostling P; Schinazi RF; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis GZ; Hoglund M; Henter J-I; Herold N
Conference publication: BLOOD. 2022;140:6290
Comparison of Data from Fresh and Frozen AML Samples for Functional Drug Testing
Struyf N; Arnroth C; Sunandar S; Bohlin A; Bengtzen S; Lehmann S; Kallioniemi O; Ostling P; Seashore-Ludlow B; Erkers T
Conference publication: BLOOD. 2022;140:6299
Data-Driven Molecular Hallmarks of Acute Myeloid Leukemia: Biological, Prognostic and Therapeutic Implications
Erkers T; Marabita F; Struyf N; Vesterlund M; James T; Arnroth C; Bohlin A; Bengtzen S; Osterroos A; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S230
NOVEL DRUG COMBINATIONS FOR NEUROBLASTOMA THERAPY - EXPLORING THE FULL POTENTIAL OF THE ROCK2-SPECIFIC INHIBITOR KD025
Tummler C; Pepich A; Vellema Q; Abu Ajamieh S; Park SW; Ljungblad L; Seashore-Ludlow B; Karlsson K; Kogner P; Johnsen JI; Nasman MW
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S227
COMBINATIONAL TREATMENT WITH ROCK INHIBITOR RKI-1447 AND BET INHIBITORS SYNERGISTICALLY IMPAIRS NEUROBLASTOMA GROWTH COMBINATIONAL TREATMENT WITH ROCK INHIBITOR RKI-1447 AND BET INHIBITORS SYNERGISTICALLY IMPAIRS NEUROBLASTOMA GROWTH
Pepich A; Tummler C; Abu Ajamieh S; Vellema Q; Akerlund E; Treis D; Seashore-Ludlow B; Kogner P; Johnsen JI; Wickstrom M
Article: MICROMACHINES. 2022;13(11):1823
A Portable, Negative-Pressure Actuated, Dynamically Tunable Microfluidic Droplet Generator
Trossbach M; Sanz MDL; Seashore-Ludlow B; Joensson HN
Article: CELL DEATH & DISEASE. 2022;13(8):714
Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention
Raivola J; Dini A; Karvonen H; Piki E; Salokas K; Niininen W; Kaleva L; Zhang K; Arjama M; Gudoityte G; Seashore-Ludlow B; Varjosalo M; Kallioniemi O; Hautaniemi S; Murumagi A; Ungureanu D
Journal article: STROKE. 2022;53(8):2559-2568
Risk of Cerebrovascular Events in Intracerebral Hemorrhage Survivors With Atrial Fibrillation: A Nationwide Cohort Study
Nielsen PB; Melgaard L; Overvad TF; Jensen M; Larsen TB; Lip GYH
Article: CELL REPORTS: METHODS. 2022;2(7):100256
Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
Sandstroem N; Carannante V; Olofsson K; Sandoz PA; Moussaud-Lamodiere EL; Seashore-Ludlow B; Van Ooijen H; Verron Q; Frisk T; Takai M; Wiklund M; Ostling P; Onfelt B
Journal article: ACS CHEMICAL BIOLOGY. 2022;17(7):1733-1744
Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature
Trapotsi M-A; Mouchet E; Williams G; Monteverde T; Juhani K; Turkki R; Miljkovic F; Martinsson A; Mervin L; Pryde KR; Mullers E; Barrett I; Engkvist O; Bender A; Moreau K
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):1890
Abstract 1890: Development of the drug efficacy testing in ex vivo 3D cultures (DETECT) platform and its application to functional precision medicine in ovarian cancer
Åkerlund E; Gudoityte G; Lamodiere EM; Carlson J; Wallin E; Fernebro J; Kallioniemi O; Östling P; Joneborg U; Seashore-Ludlow B
Conference publication: CANCER RESEARCH. 2022;82(12)
Development of the drug efficacy testing in ex vivo 3D cultures (DETECT) platform and its application to functional precision medicine in ovarian cancer
Akerlund E; Gudoityte G; Lamodiere EM; Carlson J; Wallin E; Fernebro J; Kallioniemi O; Ostling P; Joneborg U; Seashore-Ludlow B
Article: BIOMOLECULES. 2022;12(6):779
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
Qu H; Heinback R; Salo H; Ewing E; Espinosa A; Aulin C; Erlandsson Harris H
Article: NATURE GENETICS. 2022;54(3):306-317
Transcriptional kinetics and molecular functions of long noncoding RNAs
Johnsson P; Ziegenhain C; Hartmanis L; Hendriks G-J; Hagemann-Jensen M; Reinius B; Sandberg R
Article: PEDIATRIC RHEUMATOLOGY. 2021;19(1):173
Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study.
Qu H; Sundberg E; Aulin C; Neog M; Palmblad K; Horne AC; Granath F; Ek A; Melén E; Olsson M; Harris HE
Article: CANCER RESEARCH. 2021;81(22):5733-5744
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Sanjiv K; Calderon-Montano JM; Pham TM; Erkers T; Tsuber V; Almlof I; Hoglund A; Heshmati Y; Seashore-Ludlow B; Danda AN; Gad H; Wiita E; Gokturk C; Rasti A; Friedrich S; Centio A; Estruch M; Vatsveen TK; Struyf N; Visnes T; Scobie M; Koolmeister T; Henriksson M; Wallner O; Sandvall T; Lehmann S; Theilgaard-Monch K; Garnett MJ; Ostling P; Walfridsson J; Helleday T; Berglund UW
Article: NATURE. 2021;598(7879):144-150
Phenotypic variation of transcriptomic cell types in mouse motor cortex
Scala F; Kobak D; Bernabucci M; Bernaerts Y; Cadwell CR; Castro JR; Hartmanis L; Jiang X; Laturnus S; Miranda E; Mulherkar S; Tan ZH; Yao Z; Zeng H; Sandberg R; Berens P; Tolias AS
Article: NATURE. 2021;598(7879):86-102
A multimodal cell census and atlas of the mammalian primary motor cortex
Callaway EM; Dong H-W; Ecker JR; Hawrylycz MJ; Huang ZJ; Lein ES; Ngai J; Osten P; Ren B; Tolias AS; White O; Zeng H; Zhuang X; Ascoli GA; Behrens MM; Chun J; Feng G; Gee JC; Ghosh SS; Halchenko YO; Hertzano R; Lim BK; Martone ME; Ng L; Pachter L; Ropelewski AJ; Tickle TL; Yang XW; Zhang K; Bakken TE; Berens P; Daigle TL; Harris JA; Jorstad NL; Kalmbach BE; Kobak D; Li YE; Liu H; Matho KS; Mukamel EA; Naeemi M; Scala F; Tan P; Ting JT; Xie F; Zhang M; Zhang Z; Zhou J; Zingg B; Bertagnolli D; Casper T; Crichton K; Dee N; Diep D; Ding S-L; Dong W; Dougherty EL; Fong O; Goldman M; Goldy J; Hodge RD; Hu L; Keene CD; Krienen FM; Kroll M; Lake BB; Lathia K; Linnarsson S; Liu CS; Macosko EZ; McCarroll SA; McMillen D; Nadaf NM; Thuc NN; Palmer CR; Thanh P; Plongthongkum N; Reed NM; Regev A; Rimorin C; Romanow WJ; Savoia S; Siletti K; Smith K; Sulc J; Tasic B; Tieu M; Torkelson A; Tung H; van Velthoven CTJ; Vanderburg CR; Yanny AM; Fang R; Hou X; Lucero JD; Osteen JK; Pinto-Duarte A; Poirion O; Preissl S; Wang X; Aldridge AI; Bartlett A; Boggeman L; O'Connor C; Castanon RG; Chen H; Fitzpatrick C; Luo C; Nery JR; Nunn M; Rivkin AC; Tian W; Dominguez B; Ito-Cole T; Jacobs M; Jin X; Lee C-T; Lee K-F; Miyazaki PA; Pang Y; Rashid M; Smith JB; Vu M; Williams E; Armand E; Biancalani T; Booeshaghi AS; Crow M; Dudoit S; Fischer S; Gillis J; Hu Q; Kharchenko PV; Niu S-Y; Ntranos V; Purdom E; Risso D; de Bezieux HR; Somasundaram S; Street K; Svensson V; Vaishnav ED; Van den Berge K; Welch JD; Yao Z; An X; Bateup HS; Bowman I; Chance RK; Foster NN; Galbavy W; Gong H; Gou L; Hatfield JT; Hintiryan H; Hirokawa KE; Kim G; Kramer DJ; Li A; Li X; Luo Q; Munoz-Castaneda R; Stafford DA; Feng Z; Jia X; Jiang S; Jiang T; Kuang X; Larsen R; Lesnar P; Li Y; Li Y; Liu L; Peng H; Qu L; Ren M; Ruan Z; Shen E; Song Y; Wakeman W; Wang P; Wang Y; Wang Y; Yin L; Yuan J; Zhao S; Zhao X; Narasimhan A; Palaniswamy R; Banerjee S; Ding L; Huilgol D; Huo B; Kuo H-C; Laturnus S; Li X; Mitra PP; Mizrachi J; Wang Q; Xie P; Xiong F; Yu Y; Eichhorn SW; Berg J; Bernabucci M; Bernaerts Y; Cadwell CR; Castro JR; Dalley R; Hartmanis L; Horwitz GD; Jiang X; Ko AL; Miranda E; Mulherkar S; Nicovich PR; Owen SF; Sandberg R; Sorensen SA; Tan ZH; Allen S; Hockemeyer D; Lee AY; Veldman MB; Adkins RS; Ament SA; Bravo HC; Carter R; Chatterjee A; Colantuoni C; Crabtree J; Creasy H; Felix V; Giglio M; Herb BR; Kancherla J; Mahurkar A; McCracken C; Nickel L; Olley D; Orvis J; Schor M; Hood G; Dichter B; Grauer M; Helba B; Bandrowski A; Barkas N; Carlin B; D'Orazi FD; Degatano K; Gillespie TH; Khajouei F; Konwar K; Thompson C; Kelly K; Mok S; Sunkin S
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:257
Immunoprofiling of systemic juvenile idiopathic arthritis reveals distinct biomarkers characterizing disease activity
Qu H; Sundberg E; Aulin C; Neog M; Palmblad K; Horne A; Granath F; Ek A; Melen E; Olsson M; Harris HE
Article: CANCERS. 2021;13(14):3604
PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair
Ninou AH; Lehto J; Chioureas D; Stigsdotter H; Schelzig K; Akerlund E; Gudoityte G; Joneborg U; Carlson J; Jonkers J; Seashore-Ludlow B; Gustafsson NMS
Article: BIOMOLECULES. 2021;11(6):800
Disulfide and Fully Reduced HMGB1 Induce Different Macrophage Polarization and Migration Patterns
Salo H; Qu H; Mitsiou D; Aucott H; Han J; Zhang X; Aulin C; Erlandsson Harris H
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(5):580-588
The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
Mou T; Pawitan Y; Stahl M; Vesterlund M; Deng W; Jafari R; Bohlin A; Osterroos A; Siavelis L; Backvall H; Erkers T; Kiviluoto S; Seashore-Ludlow B; Ostling P; Orre LM; Kallioniemi O; Lehmann S; Lehtio J; Trung NV
Article: NATURE NANOTECHNOLOGY. 2021;16(1):85-95
A DNA-nanoassembly-based approach to map membrane protein nanoenvironments.
Ambrosetti E; Bernardinelli G; Hoffecker I; Hartmanis L; Kiriako G; de Marco A; Sandberg R; Högberg B; Teixeira AI
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(21):E8150-8150
Genotype-Based Gene Expression in Colon Tissue-Prediction Accuracy and Relationship with the Prognosis of Colorectal Cancer Patients
Deutelmoser H; Bermejo JL; Benner A; Weigl K; Park HA; Haffa M; Herpel E; Schneider M; Ulrich CM; Hoffmeister M; Chang-Claude J; Brenner H; Scherer D
Article: CANCER PREVENTION RESEARCH. 2020;13(10):817-828
Multi-omics Analysis Reveals Adipose-tumor Crosstalk in Patients with Colorectal Cancer
Holowatyj AN; Haffa M; Lin T; Scherer D; Gigic B; Ose J; Warby CA; Himbert C; Abbenhardt-Martin C; Achaintre D; Boehm J; Boucher KM; Gicquiau A; Gsur A; Habermann N; Herpel E; Kauczor H-U; Keski-Rahkonen P; Kloor M; von Knebel-Doeberitz M; Kok DE; Nattenmueller J; Schirmacher P; Schneider M; Schrotz-King P; Simon T; Ueland PM; Viskochil R; Weijenberg MP; Scalbert A; Ulrich A; Bowers LW; Hursting SD; Ulrich CM
Article: CLINICAL CANCER RESEARCH. 2020;26(18):4995-5006
Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine
Howard TP; Oberlick EM; Rees MG; Arnoff TE; Minh-Tam P; Brenan L; DoCarmo M; Hong AL; Kugener G; Chou H-C; Drosos Y; Mathias KM; Ramos P; Seashore-Ludlow B; Giacomelli AO; Wang X; Freeman BBIII; Blankenship K; Hoffmann L; Tiv HL; Gokhale PC; Johannessen CM; Stewart EA; Schreiber SL; Hahn WC; Roberts CWM
Article: FRONTIERS IN ONCOLOGY. 2020;10:1506
Adipose Tissue Properties in Tumor-Bearing Breasts
Miran I; Scherer D; Ostyn P; Mazouni C; Drusch F; Bernard M; Louvet E; Adam J; Mathieu M-C; Haffa M; Antignac J-P; Le Bizec B; Vielh P; Dessen P; Perdry H; Delaloge S; Feunteun J
Review: INTERNATIONAL IMMUNOPHARMACOLOGY. 2020;83:106446
Nanomedicine for improvement of dendritic cell-based cancer immunotherapy
Hashemi V; Farhadi S; Chaleshtari MG; Seashore-Ludlow B; Masjedi A; Hojjat-Farsangi M; Namdar A; Ajjoolabady A; Mohammadi H; Ghalamfarsa G; Jadidi-Niaragh F
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):928-943
Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC
Tran YZ; Minozada R; Cao X; Johansson HJ; Branca RM; Seashore-Ludlow B; Orre LM
Article: ELIFE. 2020;9:e52951
Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex
Cadwell CR; Scala F; Fahey PG; Kobak D; Mulherkar S; Sinz FH; Papadopoulos S; Tan ZH; Johnsson P; Hartmanis L; Li S; Cotton RJ; Tolias KF; Sandberg R; Berens P; Jiang X; Tolias AS
Editorial: GASTROENTEROLOGY. 2020;158(4):1155-1158.e2
Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multiomics Analysis
Holowatyj AN; Gigic B; Herpel E; Scalbert A; Schneider M; Ulrich CM
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2020;29(2):460-469
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study
Beyerle J; Holowatyj AN; Haffa M; Frei E; Gigic B; Schrotz-King P; Boehm J; Habermann N; Stiborova M; Scherer D; Kolsch T; Skender S; Becker N; Herpel E; Schneider M; Ulrich A; Schirmacher P; Chang-Claude J; Brenner H; Hoffmeister M; Haug U; Owen RW; Ulrich CM
Article: SLAS DISCOVERY. 2020;25(2):118-126
Perspective on CETSA Literature: Toward More Quantitative Data Interpretation
Seashore-Ludlow B; Axelsson H; Lundback T
Article: CELL DEATH AND DIFFERENTIATION. 2019;26(12):2577-2593
FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis
Turunen SP; von Nandelstadh P; Ohman T; Gucciardo E; Seashore-Ludlow B; Martins B; Rantanen V; Li H; Hopfner K; Ostling P; Varjosalo M; Lehti K
Meeting abstract: BLOOD. 2019;134:4641
High-Throughput Functional Ex-Vivo Drug Testing and Multi-Omics Profiling in Patients with Acute Myeloid Leukemia
Erkers T; Seashore-Ludlow B; Struyf N; Marabita F; James T; Malani D; Vesterlund M; Stalhl M; Pawitan Y; Lehmann S; Ostling P; Lehtio J; Kallioniemi O
Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):5075
Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas (vol 10, 4174, 2019)
Scala F; Kobak D; Shan S; Bernaerts Y; Laturnus S; Cadwell CR; Hartmanis L; Froudarakis E; Castro JR; Tan ZH; Papadopoulos S; Patel SS; Sandberg R; Berens P; Jiang X; Tolias AS
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2019;104(11):5225-5237
Transcriptome Profiling of Adipose Tissue Reveals Depot-Specific Metabolic Alterations Among Patients with Colorectal Cancer
Haffa M; Holowatyj AN; Kratz M; Toth R; Benner A; Gigic B; Habermann N; Schrotz-King P; Boehm J; Brenner H; Schneider M; Ulrich A; Herpel E; Schirmacher P; Straub BK; Nattenmueller J; Kauczor H-U; Lin T; Ball CR; Ulrich CM; Glimm H; Scherer D
Article: NATURE COMMUNICATIONS. 2019;10(1):4174
Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas
Scala F; Kobak D; Shan S; Bernaerts Y; Laturnus S; Cadwell CR; Hartmanis L; Froudarakis E; Castro JR; Tan ZH; Papadopoulos S; Patel SS; Sandberg R; Berens P; Jiang X; Tolias AS
Article: CELL REPORTS. 2019;28(9):2331-2344.e8
Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
Oberlick EM; Rees MG; Seashore-Ludlow B; Vazquez F; Nelson GM; Dharia NV; Weir BA; Tsherniak A; Ghandi M; Krill-Burger JM; Meyers RM; Wang X; Montgomery P; Root DE; Bieber JM; Radko S; Cheah JH; Hon CS-Y; Shamji AF; Clemons PA; Park PJ; Dyer MA; Golub TR; Stegmaier K; Hahn WC; Stewart EA; Schreiber SL; Roberts CWM
Article: ACS OMEGA. 2019;4(7):11642-11656
Computational and Experimental Druggability Assessment of Human DNA Glycosylases
Michel M; Visnes T; Homan EJ; Seashore-Ludlow B; Hedenstrom M; Wiita E; Vallin K; Paulin CBJ; Zhang J; Wallner O; Scobie M; Schmidt A; Jenmalm-Jensen A; Berglund UW; Helleday T
Article: NATURE. 2019;565(7738):251-254
Genomic encoding of transcriptional burst kinetics
Larsson AJM; Johnsson P; Hagemann-Jensen M; Hartmanis L; Faridani OR; Reinius B; Segerstolpe A; Rivera CM; Ren B; Sandberg R
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1888:233-254
Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines.
Rees MG; Seashore-Ludlow B; Clemons PA
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2019;28(1):76-82
Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study
Himbert C; Ose J; Nattenmueller J; Warby CA; Holowatyj AN; Boehm J; Lin T; Haffa M; Gigic B; Hardikar S; Scherer D; Zielske L; Schrotz-King P; Koelsch T; Siegel EM; Shibata D; Ulrich A; Schneider M; Hursting SD; Kauczor H-U; Ulrich CM
Article: BIOCHEMISTRY. 2018;57(48):6715-6725
Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay
Seashore-Ludlow B; Axelsson H; Almqvist H; Dahlgren B; Jonsson M; Lundback T
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(141)
Using High Content Imaging to Quantify Target Engagement in Adherent Cells
Axelsson H; Almqvist H; Seashore-Ludlow B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;499(2):136-142
Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth
Pinheiro T; Otrocka M; Seashore-Ludlow B; Rraklli V; Holmberg J; Forsberg-Nilsson K; Simon A; Kirkham M
Article: ACS CHEMICAL BIOLOGY. 2018;13(4):942-950
In Situ Target Engagement Studies in Adherent Cells
Axelsson H; Almqvist H; Otrocka M; Vallin M; Lundqvist S; Hansson P; Karlsson U; Lundback T; Seashore-Ludlow B
Article: MOLECULAR SYSTEMS BIOLOGY. 2018;14(3):e7858
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
Azimi A; Caramuta S; Seashore-Ludlow B; Bostrom J; Robinson JL; Edfors F; Tuominen R; Kemper K; Krijgsman O; Peeper DS; Nielsen J; Hansson J; Brage SE; Altun M; Uhlen M; Maddalo G
Article: CELL CHEMICAL BIOLOGY. 2018;25(2):224-229.e2
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Tang J; Tanoli Z-U; Ravikumar B; Alam Z; Rebane A; Vaha-Koskela M; Peddinti G; van Adrichem AJ; Wakkinen J; Jaiswal A; Karjalainen E; Gautam P; He L; Parri E; Khan S; Gupta A; Ali M; Yetukuri L; Gustavsson A-L; Seashore-Ludlow B; Hersey A; Leach AR; Overington JP; Repasky G; Wennerberg K; Aittokallio T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;494(3-4):477-483
A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth
Pinheiro T; Otrocka M; Seashore-Ludlow B; Rraklli V; Holmberg J; Forsberg-Nilsson K; Simon A; Kirkham M
Article: NATURE CHEMICAL BIOLOGY. 2017;13(10):1102-1108
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells
Johannessen L; Sundberg TB; O'Connell DJ; Kolde R; Berstler J; Billings KJ; Khor B; Seashore-Ludlow B; Fassl A; Russell CN; Latorre IJ; Jiang B; Graham DB; Perez JR; Sicinski P; Phillips AJ; Schreiber SL; Gray NS; Shamji AF; Xavier RJ
Article: NATURE. 2017;547(7664):453-457
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Viswanathan VS; Ryan MJ; Dhruv HD; Gill S; Eichhoff OM; Seashore-Ludlow B; Kaffenberger SD; Eaton JK; Shimada K; Aguirre AJ; Viswanathan SR; Chattopadhyay S; Tamayo P; Yang WS; Rees MG; Chen S; Boskovic ZV; Javaid S; Huang C; Wu X; Tseng Y-Y; Roider EM; Gao D; Cleary JM; Wolpin BM; Mesirov JP; Haber DA; Engelman JA; Boehm JS; Kotz JD; Hon CS; Chen Y; Hahn WC; Levesque MP; Doench JG; Berens ME; Shamji AF; Clemons PA; Stockwell BR; Schreiber SL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6231-E6239
Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery
Mateus A; Gordon LJ; Wayne GJ; Almqvist H; Axelsson H; Seashore-Ludlow B; Treyer A; Matsson P; Lundback T; West A; Hann MM; Artursson P
Article: JOURNAL OF BIOMOLECULAR SCREENING. 2016;21(10):1019-1033
Early Perspective: Microplate Applications of the Cellular Thermal Shift Assay (CETSA)
Seashore-Ludlow B; Lundback T
Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
Validation and development of MTH1 inhibitors for treatment of cancer
Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
Article: CELL DEATH & DISEASE. 2016;7(8):e2342
Bcl-x_L is an oncogenic driver in colorectal cancer
Scherr A-L; Gdynia G; Salou M; Radhakrishnan P; Duglova K; Heller A; Keim S; Kautz N; Jassowicz A; Elssner C; He Y-W; Jaeger D; Heikenwalder M; Schneider M; Weber A; Roth W; Schulze-Bergkamen H; Koehler BC
Article: CLINICAL CANCER RESEARCH. 2016;22(15):3903-3914
DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets
Hanaford AR; Archer TC; Price A; Kahlert UD; Maciac-Zyk J; Nikkhah G; Kim JW; Ehrenberger T; Clemons PA; Dancik V; Seashore-Ludlow B; Viswanathan V; Stewart ML; Rees MG; Shamji A; Schreiber S; Fraenkel E; Pomeroy SL; Mesirov JP; Tamayo P; Eberhart CG; Raabe EH
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2016;59(14):6848-6859
Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis
Brunner K; Maric S; Reshma RS; Almqvist H; Seashore-Ludlow B; Gustavsson A-L; Poyraz O; Yogeeswari P; Lundback T; Vallin M; Sriram D; Schnell R; Schneider G
Conference publication: CANCER RESEARCH. 2016;76:2476
DiSCoVERing innovative therapies for rare tumors: Combining genetically accurate disease models with advanced in silico analysis to identify novel therapeutic targets
Hanaford AR; Archer TC; Price A; Kahlert U; Maciaczyk J; Guido N; Kim W; Ehrenberger T; Clemons P; Dancik V; Seashore-Ludlow B; Viswanathan V; Stewart M; Rees M; Shamji A; Hahn W; Schreiber S; Fraenkel E; Pomeroy S; Mesirov J; Tamayo P; Eberhart CG; Raabe EH
Conference publication: NEURO-ONCOLOGY. 2016;18:120
DiSCoVERing INNOVATIVE THERAPIES: COMBINING GENETICALLY ACCURATE DISEASE MODELS OF MEDULLOBLASTOMA WITH ADVANCED IN SILICO ANALYSIS TO IDENTIFY NOVEL THERAPEUTIC TARGETS
Hanaford A; Archer T; Price A; Kahlert U; Maciaczyk J; Nikkhah G; Kim JW; Ehrenberger T; Clemons PA; Dancik V; Seashore-Ludlow B; Viswanathan V; Stewart ML; Rees MG; Shamji A; Schreiber S; Fraenkel E; Pomeroy SL; Mesirov JP; Tamayo P; Eberhart C; Raabe E
Article: NATURE CHEMICAL BIOLOGY. 2016;12(2):109-116
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
Rees MG; Seashore-Ludlow B; Cheah JH; Adams DJ; Price EV; Gill S; Javaid S; Coletti ME; Jones VL; Bodycombe NE; Soule CK; Alexander B; Li A; Montgomery P; Kotz JD; Hon CS-Y; Munoz B; Liefeld T; Dancik V; Haber DA; Clish CB; Bittker JA; Palmer M; Wagner BK; Clemons PA; Shamji AF; Schreiber SL
Article: CANCER DISCOVERY. 2015;5(11):1210-1223
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
Seashore-Ludlow B; Rees MG; Cheah JH; Cokol M; Price EV; Coletti ME; Jones V; Bodycombe NE; Soule CK; Gould J; Alexander B; Li A; Montgomery P; Wawer MJ; Kuru N; Kotz JD; Hon CS-Y; Munoz B; Liefeld T; Dancik V; Bittker JA; Palmer M; Bradner JE; Shamji AF; Clemons PA; Schreiber SL
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2015;102(2):433-443
Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study
Liesenfeld DB; Grapov D; Fahrmann JF; Salou M; Scherer D; Toth R; Habermann N; Boehm J; Schrotz-King P; Gigic B; Schneider M; Ulrich A; Herpel E; Schirmacher P; Fiehn O; Lampe JW; Ulrich CM
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2015;137(16):5563-5568
Discovery of a Small-Molecule Probe for V-ATPase Function
Adrich LN; Kuo S-Y; Castoreno AB; Goel G; Kuballa P; Rees MG; Seashore-Ludlow BA; Cheah JH; Latorre IJ; Schreiber SL; Shamji AF; Xavier RJ
Article: ACS CHEMICAL BIOLOGY. 2014;9(10):2247-2254
NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes
Adams DJ; Ito D; Rees MG; Seashore-Ludlow B; Puyang X; Ramos AH; Cheah JH; Clemons PA; Warmuth M; Zhu P; Shamji AF; Schreiber SL
Article: CELL. 2014;158(5):1199-1209
Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality
Jerby-Arnon L; Pfetzer N; Waldman YY; McGarry L; James D; Shanks E; Seashore-Ludlow B; Weinstock A; Geiger T; Clemons PA; Gottlieb E; Ruppin E
Article: HUMAN MOLECULAR GENETICS. 2014;23(8):2043-2054
Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer
Kuhmann C; Li C; Kloor M; Salou M; Weigel C; Schmidt CR; Ng LWC; Tsui WWY; Leung SY; Yuen ST; Becker N; Weichenhan D; Plass C; Schmezer P; Chan TL; Popanda O
Article: ORGANIC LETTERS. 2012;14(24):6334-6337
Asymmetric Transfer Hydrogenation Coupled with Dynamic Kinetic Resolution in Water: Synthesis of anti-β-Hydroxy-α-amino Acid Derivatives
Seashore-Ludlow B; Saint-Dizier F; Somfai P
Article: ORGANIC LETTERS. 2012;14(15):3858-3861
Domino Carbopalladation-Cross-Coupling for the Synthesis of 3,3-Disubstituted Oxindoles
Seashore-Ludlow B; Somfai P
Article: CHEMISTRY-A EUROPEAN JOURNAL. 2012;18(23):7219-7223
Enantioselective Synthesis of anti-ß-Hydroxy-a-Amido Esters by Asymmetric Transfer Hydrogenation in Emulsions
Seashore-Ludlow B; Villo P; Somfai P
Article: ADVANCED SYNTHESIS & CATALYSIS. 2012;354(1):205-216
Domino Carbopalladation-Carbonylation: Investigation of Substrate Scope
Seashore-Ludlow B; Danielsson J; Somfai P
Article: ORGANIC LETTERS. 2010;12(22):5274-5277
Enantioselective Synthesis of anti-β-Hydroxy-α-amido Esters via Transfer Hydrogenation
Seashore-Ludlow B; Villo P; Hacker C; Somfai P
Article: ORGANIC LETTERS. 2010;12(17):3732-3735
Domino Carbopalladation-Carbonylation: Generating Quaternary Stereocenters while Controlling β-Hydride Elimination
Seashore-Ludlow B; Somfai P
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2010;2010(20):3927-3933
Addition of Azomethine Ylides to Aldehydes: Mechanistic Dichotomy of Differentially Substituted α-Imino Esters
Seashore-Ludlow B; Torssell S; Somfai P
Article: TETRAHEDRON. 2010;66(26):4668-4686
A general enantioselective route to the chamigrene natural product family
White DE; Stewart IC; Seashore-Ludlow BA; Grubbs RH; Stoltz BM
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