StratRegen - Strategic research area in stem cells and regenerative medicine

Pauliina Damdimopoulou has been appointed professor at the Department of Women’s and Children’s Health (KBH), Karolinska Institutet.

Researchers at Karolinska Institutet have identified a new mechanism where circular RNA plays a crucial role in wound healing, which could lead to new therapies to improve wound healing and reduce scarring. The study was published in Advanced Science.

Women with polycystic ovary syndrome (PCOS) find it harder to get pregnant, have more frequent miscarriages and have a higher risk of developing endometrial cancer. Now, in a new study published in Nature Medicine, Swedish researchers have shown that the uterine lining of these women differs in terms of both the composition of individual cells and gene expression. The results open the door to new drug treatments.

Researchers at Karolinska Institutet have mapped the genome of the Iberian ribbed newt and revealed how the composition and organization of the DNA are linked to its ability to regenerate entire body parts.

A new study from Karolinska Institutet maps the cellular and molecular dynamics of human wound healing in exceptional detail. The study was published in Cell Stem Cell.

Researchers at Karolinska Institutet and Karolinska University Hospital have developed a microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains. The new method, called TRISCO, has the potential to transform our understanding of brain function, both in normal conditions and in disease, according to a study in Science.

Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumour growth in colorectal cancer. The discovery could lead to new treatments for inflammatory bowel disease (IBD) and cancer. The results are published in the journal Nature.

The Petropoulos and Lanner labs at CLINTEC created a reference map of early human embryo development. They also launched an ‘Early Embryogenesis Prediction Tool’ that accurately predicts cell types across different embryonic stages and datasets, with plans to expand as more data becomes available.

After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart. This is according to a new study from Karolinska Institutet published in the journal Circulation.

In a recently published study, researchers at Karolinska Institutet and KI University Hospital show that radiotherapy (RT) creates an "epigenetic memory" in skin fibroblasts which impairs skin healing in cancer survivors. They also found that by targeting this memory with antibodies the damage could be reversed. This finding can lead to new therapies for both preventing and treating RT-induced skin issues.

Researchers at Karolinska Institutet have mapped how small RNA molecules, such as the recently Nobel Prize-awarded microRNAs, control cell development in the human embryo during the first days after fertilisation. The findings, published in Nature Communications, may eventually contribute to improved fertility treatment.

A new study from Karolinska Institutet and the Chinese Academy of Medical Sciences has identified an RNA molecule that is important for skin wound healing. The research, published in Nature Communications, may have implications for the treatment of hard-to-heal wounds.

Researchers from Karolinska Institutet and Charles University studying liver fibrosis have made an exciting new discovery, now published in EMBO Molecular Medicine. Their latest findings could pave the way for innovative approaches to treating this challenging condition.

Researchers at Karolinska Institutet and AstraZeneca have discovered that gene expression in adipose stem cells varies according to sex and type of adipose tissue in mice. These findings may pave the way for future therapeutic interventions to increase the body's fat storage capacity and improve metabolism.

Elif Eroglu, research group leader at the Department of Cell and Molecular Biology (CMB).
Project title: “Tightly Controlled – Tight Junctions and Tissue Mechanics as Sensors and Executers of Heart Regeneration” and William A. Nyberg, assistant professor at the Department of Medicine, Huddinge. Project title: “Improving CAR-T cell therapies through AAV-mediated genetic engineering” 

Docent Georgios Sotiriou tilldelas ERC Proof of Concept-anslaget från Europeiska forskningsrådet (ERC). Syftet med Photocure-projektet är dels att undersöka om en ljusaktiverad nanokompositfilm kan vara en effektiv behandling för svåra, infekterade sår som till exempel diabetiska fotsår. Men också att förbereda steget från innovation till medicinteknisk produkt. Det är andra gången Georgios Sotiriou tilldelas det prestigefyllda anslaget, och tredje gången han får finansiering från ERC.

New research reveals that scar formation after spinal cord injuries is more complex than previously thought. Scientists have identified two types of perivascular cells as key contributors to scar tissue, which hinders nerve regeneration and functional recovery. These findings are also relevant for other brain and spinal cord injuries and could lead to targeted therapies for reducing scarring and improving outcomes.

Zebrafish have a remarkable ability to heal their spinal cord after injury. Now, researchers at Karolinska Institutet have uncovered an important mechanism behind this phenomenon – a finding that could have implications for the treatment of spinal cord injury in humans.

The 2024 Svedberg Prize is awarded to Björn Reinius, Department of Medical Biochemistry and Biophysics at Karolinska Institutet, for his discoveries regarding the gene regulation mechanisms of the X chromosome and his substantial impact on COVID-19 clinical diagnostics.

KI-researcher Pauliina Damdimopoulou has been awarded a EUR 2 million ERC Consolidator Grant (European Research Council) for the SAFER project (SAfeguarding female FERtility-development of human-relevant in vitro tools for reproductive toxicity). The research will investigate the impact of commonly occurring environmental chemical contaminants on women's reproductive health.