Enheten för molekylär toxikologi

Enhetens forskning syftar till att identifiera och karaktärisera molekylära och biokemiska processer som induceras vid exponering för toxiska ämnen såsom nanomaterial.

En del av:

Publikationer

Utvalda publikationer

Finansiering

Forskningsbidrag

  • European Commission
    1 December 2024 - 30 November 2028
  • European Commission
    1 March 2023 - 28 February 2027
  • Swedish Research Council
    1 January 2022 - 31 December 2025
    Two-dimensional (2D) materials beyond graphene have attracted considerable interest due to their unique physicochemical properties. The overall aim of the current proposal is to expand our knowledge regarding the biological interactions of 2D materials, i.e., transition metal dichalcogenides (TMDs) and transition metal carbides, carbonitrides, and nitrides (collectively known as MXenes). We will place particular emphasis on inflammation, the process by which our body protects us from harm, and we will address interactions with lung cells, as inhalation is an important route of exposure to foreign materials. This proposal builds on previous research on graphene-based materials, and the goal is to pave the way for safe and sustainable handling and use of 2D materials. The specific aims of this project are: (i) to profile the interactions of 2D materials with peripheral blood mononuclear cells with respect to cytocompatibility and cytokine responses using advanced single-cell analysis
    (ii) to study the effects of 2D materials on primary human macrophages and lung cells, and the putative biotransformation of 2D materials in these cells
    (iii) to investigate the biological impact of 2D materials at the molecular level using genome-wide transcriptomics approaches coupled with mass spectrometry-based proteomics
    (iv) to explore the biological interactions of 2D materials in vivo using zebrafish embryos to model inflammation.
  • MISTRA - Stiftelsen för miljöstrategisk forskning
    1 January 2014 - 30 September 2023
  • European Commission
    1 October 2013 - 30 September 2023

Medarbetare och kontakt

Enhetschef

Alla medarbetare i gruppen

Besöksadress

Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, Stockholm, 171 77, Sweden

Postadress

Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, Stockholm, 171 77, Sweden

Nyckelord:
Farmakologi och toxikologi Inflammation Nanomedicin Nanotekniska livsvetenskaper och medicin Toxikologi
Innehållsgranskare:
Bengt Fadeel
Anna Persson
2025-09-04