Bengt Fadeel

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Bengt Fadeel är leg. läkare och professor i medicinsk inflammationsforskning

samt vice prefekt vid Institutet för miljömedicin (IMM) vid Karolinska Institutet.

Prof. Fadeel är ledamot av The Academy of Toxicological Sciences (ATS) (2012)
samt Academia Europaea (Class of Biochemistry and Molecular Biology) (2024).

Forskningsbeskrivning

För information om Bengt Fadeels verksamhet, se Enheten för molekylär toxikologi.

Artiklar

Journal article: CARBON. 2025;242:120430
Revisiting the nomenclature for two-dimensional carbon materials
Gulumian M; Fadeel B
Article: ACS NANO. 2025;19(20):19057-19079
Nanodiamonds Interact with Primary Human Macrophages and Dendritic Cells Evoking a Vigorous Interferon Response
Malina T; Kaur J; Martin S; Gallud A; Katayama S; Gazzi A; Orecchioni M; Petr M; Srejber M; Haag L; Hamawandi B; Toprak MS; Kere J; Delogu LG; Fadeel B
Journal article: ADVANCED HEALTHCARE MATERIALS. 2025;14(10)
Biocompatibility of Water‐Dispersible Pristine Graphene and Graphene Oxide Using a Close‐to‐Human Animal Model: A Pilot Study on Swine (Adv. Healthcare Mater. 10/2025)
Nicolussi P; Pilo G; Cancedda MG; Peng G; Do Quyen Chau N; De la Cadena A; Vanna R; Samad YA; Ahmed T; Marcellino J; Tedde G; Giro L; Ylmazer A; Loi F; Carta G; Secchi L; Dei Giudici S; Macciocu S; Polli D; Nishina Y; Ligios C; Cerullo G; Ferrari A; Bianco A; Fadeel B; Franzoni G; Delogu LG
Article: SMALL. 2025;21(7):e2404570
Safety Assessment of Graphene-Based Materials
Fadeel B; Baker J; Ballerini L; Bussy C; Candotto Carniel F; Tretiach M; Pelin M; Buerki-Thurnherr T; Kanerva T; Navas JM; Vazquez E; Rodriguez Unamuno V; Lehtonen P; Gonzalez M; Rauscher H; Riego Sintes J; Kostarelos K; Bianco A; Prato M
Article: SCIENTIFIC REPORTS. 2024;14(1):31030
Maximizing the safety and sustainability of MXenes
Hansen SF; Nielsen MB; Skjolding LM; Kaur J; Desivyana N; Hermansson F; Bird J; Barg S; Khort A; Odnevall I; Fadeel B; Arvidsson R
Article: NPJ PRECISION ONCOLOGY. 2024;8(1):284
ACSL3 is an unfavorable prognostic marker in cholangiocarcinoma patients and confers ferroptosis resistance in cholangiocarcinoma cells
Sae-Fung A; Vinayavekhin N; Fadeel B; Jitkaew S
Article: ADVANCED HEALTHCARE MATERIALS. 2024;14(10):e2401783
Biocompatibility of Water-Dispersible Pristine Graphene and Graphene Oxide Using a Close-to-Human Animal Model: A Pilot Study on Swine
Nicolussi P; Pilo G; Cancedda MG; Peng G; Chau NDQ; de la Cadena A; Vanna R; Samad YA; Ahmed T; Marcellino J; Tedde G; Giro L; Ylmazer A; Loi F; Carta G; Secchi L; Dei Giudici S; Macciocu S; Polli D; Nishina Y; Ligios C; Cerullo G; Ferrari A; Bianco A; Fadeel B; Franzoni G; Delogu LG
Article: CHEMOSPHERE. 2024;366:143513
Putting advanced materials to the test: Ti3C2 MXenes alleviate the hazardous effects of the environmental pollutant benzo[a]pyrene.
Kaur J; Khort A; Sadiktsis I; Preethika M; Bird JRT; Barg S; Odnevall I; Fadeel B
Article: ADVANCED SCIENCE. 2024;11(32):e2400389
A Network Toxicology Approach for Mechanistic Modelling of Nanomaterial Hazard and Adverse Outcomes
del Giudice G; Serra A; Pavel A; Torres Maia M; Saarimaki LA; Fratello M; Federico A; Alenius H; Fadeel B; Greco D
Article: JOURNAL OF HAZARDOUS MATERIALS. 2024;473:134686
Hazard assessment of hexagonal boron nitride and hexagonal boron nitride reinforced thermoplastic polyurethane composites using human skin and lung cells
Carlin M; Kaur J; Ciobanu DZ; Song Z; Olsson M; Totu T; Gupta G; Peng G; Gonzalez VJ; Janica I; Pozo VF; Chortarea S; Buljan M; Buerki-Thurnherr T; Castillo AEDR; Thorat SB; Bonaccorso F; Tubaro A; Vazquez E; Prato M; Armirotti A; Wick P; Bianco A; Fadeel B; Pelin M
Article: SMALL. 2024;20(28):e2310540
Nanosafety: a Perspective on Nano-Bio Interactions
Fadeel B; Keller AA
Article: NANOSCALE ADVANCES. 2024;6(9):2419-2430
Cytotoxicity assessment of exfoliated MoS₂ using primary human mast cells and the progenitor cell-derived mast cell line LAD2
Lin H; Castillo AEDR; Gonzalez VJ; Bonaccorso F; Vazquez E; Fadeel B; Bianco A
Article: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2024;55:102714
Exploiting the ferroaddiction of pancreatic cancer cells using Fe-doped nanoparticles
Lomphithak T; Sae-Fung A; Sprio S; Tampieri A; Jitkaew S; Fadeel B
Journal article: CURRENT OPINION IN TOXICOLOGY. 2023;36:100427
2D materials and the microbiome: More than a gut feeling
Peng G; Fadeel B
Article: NANOSCALE. 2023;15(43):17409-17421
Two-dimensional molybdenum disulfide nanosheets evoke nitric oxide-dependent antibacterial effects
Peng G; Gonzalez V; Vazquez E; Lundberg JO; Fadeel B
Article: NANOSCALE ADVANCES. 2023;5(13):3453-3462
Label-free detection of polystyrene nanoparticles in Daphnia magna using Raman confocal mapping
Kaur J; Kelpsiene E; Gupta G; Dobryden I; Cedervall T; Fadeel B
Article: NANOMATERIALS. 2023;13(11):1719
High-Dose Exposure to Polymer-Coated Iron Oxide Nanoparticles Elicits Autophagy-Dependent Ferroptosis in Susceptible Cancer Cells
Lomphithak T; Helvacioglu S; Armenia I; Keshavan S; Ovejero JG; Baldi G; Ravagli C; Grazu V; Fadeel B
Article: FRONTIERS IN TOXICOLOGY. 2023;5:1254748
Don't sweat the small stuff: a conversation about nanosafety
Fadeel B; Sayre P
Article: PLOS ONE. 2023;18(9):e0288737
Nanomaterial genotoxicity evaluation using the high-throughput p53-binding protein 1 (53BP1) assay
Fontaine M; Bartolami E; Prono M; Beal D; Blosi M; Costa AL; Ravagli C; Baldi G; Sprio S; Tampieri A; Fenoglio I; Tran L; Fadeel B; Carriere M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2022;633:45-51
Nanomaterial characterization: Understanding nano-bio interactions
Fadeel B
Article: JOURNAL OF HAZARDOUS MATERIALS. 2022;435:129053
Hazard assessment of abraded thermoplastic composites reinforced with reduced graphene oxide
Chortarea S; Kuru OC; Netkueakul W; Pelin M; Keshavan S; Song Z; Ma B; Gomes J; Villaro Abalos E; de Luna LAV; Loret T; Fordham A; Drummond M; Kontis N; Anagnostopoulos G; Paterakis G; Cataldi P; Tubaro A; Galiotis C; Kinloch I; Fadeel B; Bussy C; Kostarelos K; Buerki-Thurnherr T; Prato M; Bianco A; Wick P
Article: PARTICLE AND FIBRE TOXICOLOGY. 2022;19(1):33
Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu/Zn superoxide dismutase 1 (SOD1)
Gupta G; Cappellini F; Farcal L; Gornati R; Bernardini G; Fadeel B
Article: FRONTIERS IN TOXICOLOGY. 2022;4:974429
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials
Martin S; de Haan L; Estruch IM; Eder KM; Marzi A; Schnekenburger J; Blosi M; Costa A; Antonello G; Bergamaschi E; Riganti C; Beal D; Carriere M; Tache O; Hutchison G; Malone E; Young L; Campagnolo L; La Civita F; Pietroiusti A; Devineau S; Baeza A; Boland S; Zong C; Ichihara G; Fadeel B; Bouwmeester H
Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:1083232
Silver nanoparticles with excellent biocompatibility block pseudotyped SARS-CoV-2 in the presence of lung surfactant
Gupta G; Hamawandi B; Sheward DJ; Murrell B; Hanke L; McInerney G; Blosi M; Costa AL; Toprak MS; Fadeel B
Article: NANOTOXICOLOGY. 2021;15(9):1125-1150
Multi-walled carbon nanotubes trigger lysosome-dependent cell death (pyroptosis) in macrophages but not in neutrophils
Keshavan S; Gupta G; Martin S; Fadeel B
Article: NANOSCALE. 2021;13(30):13072-13084
Biodegradation of graphdiyne oxide in classically activated (M1) macrophages modulates cytokine production
Peng G; Duan T; Guo M; Xue Y; Chen C; Li Y; Leifer K; Fadeel B
Article: CARBON. 2021;178:563-572
Multi-walled carbon nanotubes elicit concordant changes in DNA methylation and gene expression following long-term pulmonary exposure in mice
Scala G; Delaval MN; Mukherjee SP; Federico A; Khaliullin TO; Yanamala N; Fatkhutdinova LM; Kisin ER; Greco D; Fadeel B; Shvedova AA
Article: ADVANCED SCIENCE. 2021;8(10):2004588
Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways
Kinaret PAS; Ndika J; Ilves M; Wolff H; Vales G; Norppa H; Savolainen K; Skoog T; Kere J; Moya S; Handy RD; Karisola P; Fadeel B; Greco D; Alenius H
Article: NANOIMPACT. 2021;22:100313
Pulmonary toxicity and gene expression changes after short-term inhalation exposure to surface-modified copper oxide nanoparticles
Gosens I; Costa PM; Olsson M; Stone V; Costa AL; Brunelli A; Badetti E; Bonetto A; Bokkers BGH; de Jong WH; Williams A; Halappanavar S; Fadeel B; Cassee FR
Article: NANOMEDICINE. 2021;16(9):689-707
Efficacy, biocompatibility and degradability of carbon nanoparticles for photothermal therapy of lung cancer
Kokalari I; Keshavan S; Rahman M; Gazzano E; Barzan G; Mandrile L; Giovannozzi A; Ponti J; Antonello G; Monopoli M; Perrone G; Bergamaschi E; Riganti C; Fadeel B; Fenoglio I
Article: NANOMATERIALS. 2021;11(4):883
Profiling of Sub-Lethal in Vitro Effects of Multi-Walled Carbon Nanotubes Reveals Changes in Chemokines and Chemokine Receptors
Keshavan S; Torres Andon F; Gallud A; Chen W; Reinert K; Tran L; Fadeel B
Article: FRONTIERS IN TOXICOLOGY. 2021;3:735331
Development of Microfluidic, Serum-Free Bronchial Epithelial Cells-on-a-Chip to Facilitate a More Realistic In vitro Testing of Nanoplastics
Gupta G; Vallabani S; Bordes R; Bhattacharya K; Fadeel B
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2021;192(1):200-211
Severe congenital neutropenia-associated JAGN1 mutations unleash a calpain-dependent cell death programme in myeloid cells
Khandagale A; Holmlund T; Entesarian M; Nilsson D; Kalwak K; Klaudel-Dreszler M; Carlsson G; Henter J-I; Nordenskjold M; Fadeel B
Journal article: PRECISION NANOMEDICINE. 2020;3(4):709
Comment on “The long life of unicorns”
Fadeel B
Article: ADVANCED SCIENCE. 2020;7(22):2002221
Multiparametric Profiling of Engineered Nanomaterials: Unmasking the Surface Coating Effect
Gallud A; Delaval M; Kinaret P; Marwah VS; Fortino V; Ytterberg J; Zubarev R; Skoog T; Kere J; Correia M; Loeschner K; Al-Ahmady Z; Kostarelos K; Ruiz J; Astruc D; Monopoli M; Handy R; Moya S; Savolainen K; Alenius H; Greco D; Fadeel B
Article: MATERIALS. 2020;13(20):E4532-4532
Risk Management Framework for Nano-Biomaterials Used in Medical Devices and Advanced Therapy Medicinal Products
Giubilato E; Cazzagon V; Amorim MJB; Blosi M; Bouillard J; Bouwmeester H; Costa AL; Fadeel B; Fernandes TF; Fito C; Hauser M; Marcomini A; Nowack B; Pizzol L; Powell L; Prina-Mello A; Sarimveis H; Scott-Fordsmand JJ; Semenzin E; Stahlmecke B; Stone V; Vignes A; Wilkins T; Zabeo A; Tran L; Hristozov D
Article: NANOSCALE. 2020;12(32):16730-16737
Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract
Peng G; Montenegro MF; Ntola CNM; Vranic S; Kostarelos K; Vogt C; Toprak MS; Duan T; Leifer K; Brautigam L; Lundberg JO; Fadeel B
Article: JOURNAL OF PHYSICS-MATERIALS. 2020;3(3):034009
Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design
Gazzi A; Fusco L; Orecchioni M; Ferrari S; Franzoni G; Yan JS; Rieckher M; Peng G; Lucherelli MA; Anna Vacchi I; Ngoc DQC; Criado A; Istif A; Mancino D; Dominguez A; Eckert H; Vazquez E; Da Ros T; Nicolussi P; Palermo V; Schumacher B; Cuniberti G; Mai Y; Clementi C; Pasquali M; Feng X; Kostarelos K; Yilmazer A; Bedognetti D; Fadeel B; Prato M; Bianco A; Delogu LG
Article: ADVANCED SCIENCE. 2020;7(12):1903200
Size-Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice: Toward Safe-by-Design
Rodrigues AF; Newman L; Jasim D; Mukherjee SP; Wang J; Vacchi IA; Menard-Moyon C; Bianco A; Fadeel B; Kostarelos K; Bussy C
Article: CARBON. 2020;159:598-610
Keratinocytes are capable of selectively sensing low amounts of graphene-based materials: Implications for cutaneous applications
Fusco L; Pelin M; Mukherjee S; Keshavan S; Sosa S; Martin C; Gonzalez V; Vazquez E; Prato M; Fadeel B; Tubaro A
Article: FASEB JOURNAL. 2020;34(4):5262-5281
Cobalt nanoparticles trigger ferroptosis-like cell death (oxytosis) in neuronal cells: Potential implications for neurodegenerative disease
Gupta G; Gliga A; Hedberg J; Serra A; Greco D; Odnevall Wallinder I; Fadeel B
Article: NANOSCALE ADVANCES. 2020;2(2):648-658
Silver nanoparticles modulate lipopolysaccharide-triggered Toll-like receptor signaling in immune-competent human cell lines
Gliga AR; De Loma J; Di Bucchianico S; Skoglund S; Keshavan S; Odnevall Wallinder I; Karlsson HL; Fadeel B
Article: FRONTIERS IN TOXICOLOGY. 2020;2:4
Covid-19 Misinformation Alert, or: "Wash Your Hands and Eat Your Veggies!"
Fadeel B
Article: NANOSCALE. 2019;11(45):22006-22018
Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer
Madamsetty VS; Pal K; Keshavan S; Caulfield TR; Dutta SK; Wang E; Fadeel B; Mukhopadhyay D
Article: JOURNAL OF IMMUNOLOGY. 2019;203(8):2276-2290
Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells
Lazzaretto B; Fadeel B
Article: ADVANCED FUNCTIONAL MATERIALS. 2019;29(39)
A Biodegradable Multifunctional Graphene Oxide Platform for Targeted Cancer Therapy
Martin C; Ruiz A; Keshavan S; Reina G; Murera D; Nishina Y; Fadeel B; Bianco A
Journal article: NATURE NANOTECHNOLOGY. 2019;14(9):902
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine.
Leong HS; Butler KS; Brinker CJ; Azzawi M; Conlan S; Dufès C; Owen A; Rannard S; Scott C; Chen C; Dobrovolskaia MA; Kozlov SV; Prina-Mello A; Schmid R; Wick P; Caputo F; Boisseau P; Crist RM; McNeil SE; Fadeel B; Tran L; Hansen SF; Hartmann NB; Clausen LPW; Skjolding LM; Baun A; Ågerstrand M; Gu Z; Lamprou DA; Hoskins C; Huang L; Song W; Cao H; Liu X; Jandt KD; Jiang W; Kim BYS; Wheeler KE; Chetwynd AJ; Lynch I; Moghimi SM; Nel A; Xia T; Weiss PS; Sarmento B; das Neves J; Santos HA; Santos L; Mitragotri S; Little S; Peer D; Amiji MM; Alonso MJ; Petri-Fink A; Balog S; Lee A; Drasler B; Rothen-Rutishauser B; Wilhelm S; Acar H; Harrison RG; Mao C; Mukherjee P; Ramesh R; McNally LR; Busatto S; Wolfram J; Bergese P; Ferrari M; Fang RH; Zhang L; Zheng J; Peng C; Du B; Yu M; Charron DM; Zheng G; Pastore C
Journal article: NATURE NANOTECHNOLOGY. 2019;14(8):811
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine.
Leong HS; Butler KS; Brinker CJ; Azzawi M; Conlan S; Dufès C; Owen A; Rannard S; Scott C; Chen C; Dobrovolskaia MA; Kozlov SV; Prina-Mello A; Schmid R; Wick P; Caputo F; Boisseau P; Crist RM; McNeil SE; Fadeel B; Tran L; Hansen SF; Hartmann NB; Clausen LPW; Skjolding LM; Baun A; Ågerstrand M; Gu Z; Lamprou DA; Hoskins C; Huang L; Song W; Cao H; Liu X; Jandt KD; Jiang W; Kim BYS; Wheeler KE; Chetwynd AJ; Lynch I; Moghimi SM; Nel A; Xia T; Weiss PS; Sarmento B; Neves JD; Santos HA; Santos L; Mitragotri S; Little S; Peer D; Amiji MM; Alonso MJ; Petri-Fink A; Balog S; Lee A; Drasler B; Rothen-Rutishauser B; Wilhelm S; Acar H; Harrison RG; Mao C; Mukherjee P; Ramesh R; McNally LR; Busatto S; Wolfram J; Bergese P; Ferrari M; Fang RH; Zhang L; Zheng J; Peng C; Du B; Yu M; Charron DM; Zheng G; Pastore C
Article: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2019;18:112-121
Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer
Madamsetty VS; Sharma A; Toma M; Samaniego S; Gallud A; Wang E; Pal K; Mukhopadhyay D; Fadeel B
Article: FASEB JOURNAL. 2019;33(4):4962-4974
Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment
Zaman F; Zhao Y; Celvin B; Mehta HH; Wan J; Chrysis D; Ohlsson C; Fadeel B; Cohen P; Savendahl L
Article: SCIENTIFIC REPORTS. 2019;9(1):4366
Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study
Gallud A; Kloditz K; Ytterberg J; Ostberg N; Katayama S; Skoog T; Gogvadze V; Chen Y-Z; Xue D; Moya S; Ruiz J; Astruc D; Zubarev R; Kere J; Fadeel B
Article: JOURNAL OF CELL SCIENCE. 2019;132(5):jcs227660
Structure and function analysis of the C-elegans aminophospholipid translocase TAT-1
Chen Y-Z; Kloditz K; Lee E-S; Nguyen DP; Yuan Q; Johnson J; Lee-yow Y; Hall A; Mitani S; Xia N-S; Fadeel B; Xue D
Article: SCIENTIFIC REPORTS. 2019;9(1):179
INSIdE NANO: a systems biology framework to contextualize the mechanism-of-action of engineered nanomaterials
Serra A; Letunic I; Fortino V; Handy RD; Fadeel B; Tagliaferri R; Greco D
Article: CELL DEATH DISCOVERY. 2019;5:65
Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death
Kloditz K; Fadeel B
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2018;104(6):1199-1213
JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia
Khandagale A; Lazzaretto B; Carlsson G; Sundin M; Shafeeq S; Romling U; Fadeel B
Journal article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2018;130(36):11896-11901
Degradation of Single‐Layer and Few‐Layer Graphene by Neutrophil Myeloperoxidase
Kurapati R; Mukherjee SP; Martín C; Bepete G; Vázquez E; Pénicaud A; Fadeel B; Bianco A
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2018;57(36):11722-11727
Degradation of Single-Layer and Few-Layer Graphene by Neutrophil Myeloperoxidase
Kurapati R; Mukherjee SP; Martin C; Bepete G; Vazquez E; Penicaud A; Fadeel B; Bianco A
Article: PARTICLE AND FIBRE TOXICOLOGY. 2018;15(1):32
Calcium-dependent cyto- and genotoxicity of nickel metal and nickel oxide nanoparticles in human lung cells
Di Bucchianico S; Gliga AR; Akerlund E; Skoglund S; Wallinder IO; Fadeel B; Karlsson HL
Article: SCIENTIFIC REPORTS. 2018;8(1):6668
RNA-sequencing reveals long-term effects of silver nanoparticles on human lung cells
Gliga AR; Di Bucchianico S; Lindvall J; Fadeel B; Karlsson HL
Article: CHEMOSPHERE. 2018;196:482-493
Toxicity of surface-modified copper oxide nanoparticles in a mouse macrophage cell line: Interplay of particles, surface coating and particle dissolution
Libalova H; Costa PM; Olsson M; Farcal L; Ortelli S; Blosi M; Topinka J; Costa AL; Fadeel B
Article: ADVANCED HEALTHCARE MATERIALS. 2018;7(6):e1700916
Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery
Bhattacharya K; Sacchetti C; Costa PM; Sommertune J; Brandner BD; Magrini A; Rosato N; Bottini N; Bottini M; Fadeel B
Article: JOURNAL OF APPLIED TOXICOLOGY. 2018;38(3):385-397
Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short-term inhalation exposure to copper oxide nanoparticles
Costa PM; Gosens I; Williams A; Farcal L; Pantano D; Brown DM; Stone V; Cassee FR; Halappanavar S; Fadeel B
Article: ADVANCED HEALTHCARE MATERIALS. 2018;7(4)
Cytokine Profiling of Primary Human Macrophages Exposed to Endotoxin-Free Graphene Oxide: Size-Independent NLRP3 Inflammasome Activation
Mukherjee SP; Kostarelos K; Fadeel B
Article: SCIENTIFIC REPORTS. 2018;8(1):1115
Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors
Mukherjee SP; Bondarenko O; Kohonen P; Andon FT; Brzicova T; Gessner I; Mathur S; Bottini M; Calligari P; Stella L; Kisin E; Shvedova A; Autio R; Salminen-Mankonen H; Lahesmaa R; Fadeel B
Article: NANOSCALE. 2018;10(3):1180-1188
Graphene oxide is degraded by neutrophils and the degradation products are non-genotoxic
Mukherjee SP; Gliga AR; Lazzaretto B; Brandner B; Fielden M; Vogt C; Newman L; Rodrigues AF; Shao W; Fournier PM; Toprak MS; Star A; Kostarelos K; Bhattacharya K; Fadeel B
Article: 2D MATERIALS. 2018;5(3):035020
A blueprint for the synthesis and characterisation of thin graphene oxide with controlled lateral dimensions for biomedicine
Rodrigues AF; Newman L; Lozano N; Mukherjee SP; Fadeel B; Bussy C; Kostarelos K
Article: JOURNAL OF IMMUNOTOXICOLOGY. 2018;15(1):12-23
Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice
Park E-J; Khaliullin TO; Shurin MR; Kisin ER; Yanamala N; Fadeel B; Chang J; Shvedova AA
Article: SCIENTIFIC REPORTS. 2017;7(1):9284
Cerium oxide nanoparticles inhibit differentiation of neural stem cells
Gliga AR; Edoff K; Caputo F; Kallman T; Blom H; Karlsson HL; Ghibelli L; Traversa E; Ceccatelli S; Fadeel B
Article: NANOTOXICOLOGY. 2017;11(6):809-826
Cytotoxicity screening and cytokine profiling of nineteen nanomaterials enables hazard ranking and grouping based on inflammogenic potential
Bhattacharya K; Kilic G; Costa PM; Fadeel B
Article: LAKARTIDNINGEN. 2017;114:EIAA
[Nano for better or worse: opportunities and risks with nanotechnology].
Fadeel B
Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):44
Effect of FCGR polymorphism on the occurrence of late-onset neutropenia and flare-free survival in rheumatic patients treated with rituximab
Ajeganova S; Tesfa D; Hgglund H; Fadeel B; Vedin I; Zignego AL; Palmblad J
Article: CARBON. 2017;113:243-251
Hollow carbon spheres trigger inflammasome-dependent IL-1β secretion in macrophages
Andon FT; Mukherjee SP; Gessner I; Wortmann L; Xiao L; Hultenby K; Shvedova AA; Mathur S; Fadeel B
Article: BIOMATERIALS. 2017;121:28-40
Macrophage activation status determines the internalization of mesoporous silica particles of different sizes: Exploring the role of different pattern recognition receptors
Gallud A; Bondarenko O; Feliu N; Kupferschmidt N; Atluri R; Garcia-Bennett A; Fadeel B
Article: CHEMOSPHERE. 2017;171:671-680
Fibrillar vs crystalline nanocellulose pulmonary epithelial cell responses: Cytotoxicity or inflammation?
Menas AL; Yanamala N; Farcas MT; Russo M; Friend S; Fournier PM; Star A; Iavicoli I; Shurin GV; Vogel UB; Fadeel B; Beezhold D; Kisin ER; Shvedova AA
Article: JOURNAL OF PROTEOME RESEARCH. 2017;16(2):689-697
Cytotoxic and Proinflammatory Effects of Metal-Based Nanoparticles on THP-1 Monocytes Characterized by Combined Proteomics Approaches
Tarasova NK; Gallud A; Ytterberg AJ; Chernobrovkin A; Aranzaes JR; Astruc D; Antipov A; Fedutik Y; Fadeel B; Zubarev RA
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;482(3):482-490
Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids
Kagan VE; Bayir H; Tyurina YY; Bolevich SB; Maguire JJ; Fadeel B; Balasubramanian K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;482(3):491-497
Programmed cell clearance: From nematodes to humans
Kloditz K; Chen Y-Z; Xue D; Fadeel B
Article: ONCOTARGET. 2016;7(30):48360-48374
PD1 blockade enhances cytotoxicity of in vitro expanded natural killer cells towards myeloma cells
Guo Y; Feng X; Jiang Y; Shi X; Xing X; Liu X; Li N; Fadeel B; Zheng C
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2016;31(6):1275-1286
Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1^-/- and Phospho1/P_it1 Double-Knockout Mice
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Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2016;299:101-111
Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and risk
Costa PM; Fadeel B
Article: SCIENTIFIC REPORTS. 2016;6:21316
Single-Walled Carbon Nanotubes Inhibit the Cytochrome P450 Enzyme, CYP3A4
El-Sayed R; Bhattacharya K; Gu Z; Yang Z; Weber JK; Li H; Leifer K; Zhao Y; Toprak MS; Zhou R; Fadeel B
Article: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2016;12(2):255-268
Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy
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Detection of Endotoxin Contamination of Graphene Based Materials Using the TNF-α Expression Test and Guidelines for Endotoxin-Free Graphene Oxide Production
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Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant
Bhattacharya K; El-Sayed R; Andon FT; Mukherjee SP; Gregory J; Li H; Zhao Y; Seo W; Fornara A; Brandner B; Toprak MS; Leifer K; Star A; Fadeel B
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2015;95(Pt A):3-12
It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system
Farrera C; Fadeel B
Journal article: EUROPEAN JOURNAL OF NANOMEDICINE. 2015;7(3):143-151
Keeping it small: towards a molecular definition of nanotoxicology
Gallud A; Fadeel B
Journal article: EUROPEAN JOURNAL OF NANOMEDICINE. 2015;7(3):141-142
Sizing up the safety of nanomaterials
Fadeel B
Article: ACS NANO. 2015;9(1):146-163
Next-Generation Sequencing Reveals Low-Dose Effects of Cationic Dendrimers in Primary Human Bronchial Epithelial Cells
Feliu N; Kohonen P; Ji J; Zhang Y; Karlsson HL; Palmberg L; Nystrom A; Fadeel B
Article: BEILSTEIN JOURNAL OF NANOTECHNOLOGY. 2015;6:1609-1634
The eNanoMapper database for nanomaterial safety information
Jeliazkova N; Chomenidis C; Doganis P; Fadeel B; Grafstrom R; Hardy B; Hastings J; Hegi M; Jeliazkov V; Kochev N; Kohonen P; Munteanu CR; Sarimveis H; Smeets B; Sopasakis P; Tsiliki G; Vorgrimmler D; Willighagen E
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Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages
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Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy
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Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes
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Shifting identities of metal oxide nanoparticles: Focus on inflammation
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Article: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2014;10(7):1421-1431
Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum
Krais A; Wortmann L; Hermanns L; Feliu N; Vahter M; Stucky S; Mathur S; Fadeel B
Article: PARTICLE AND FIBRE TOXICOLOGY. 2014;11:41
Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines
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Article: FEBS LETTERS. 2014;588(17):2921-2927
Exploring the anti-apoptotic role of HAX-1 versus BCL-X_L in cytokine-dependent bone marrow-derived cells from mice
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Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2014;53(30):7714-7718
Classification Framework for Graphene-Based Materials
Wick P; Louw-Gaume AE; Kucki M; Krug HF; Kostarelos K; Fadeel B; Dawson KA; Salvati A; Vazquez E; Ballerini L; Tretiach M; Benfenati F; Flahaut E; Gauthier L; Prato M; Bianco A
Article: CELL DEATH & DISEASE. 2014;5(7):e1312
Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals
Maeda A; Fadeel B
Article: ACS NANO. 2014;8(6):5585-5599
Graphene Oxide Attenuates Th2-Type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine Model of Asthma
Shurin MR; Yanamala N; Kisin ER; Tkach AV; Shurin GV; Murray AR; Leonard HD; Reynolds JS; Gutkin DW; Star A; Fadeel B; Savolainen K; Kagan VE; Shvedova AA
Article: NANOSCALE. 2014;6(12):6974-6983
Extracellular entrapment and degradation of single-walled carbon nanotubes
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Article: ANTI-CANCER DRUGS. 2014;25(3):282-288
Bortezomib and IL-12 produce synergetic anti-multiple myeloma effects with reduced toxicity to natural killer cells
Wang X; Feng X; Wang J; Shao N; Ji C; Ma D; Henter J-I; Fadeel B; Zheng C
Article: EXPERIMENTAL HEMATOLOGY. 2014;42(3):172-182
Proapoptotic effects of the novel proteasome inhibitor b-AP15 on multiple myeloma cells and natural killer cells
Feng X; Holmlund T; Zheng C; Fadeel B
Article: PARTICLE AND FIBRE TOXICOLOGY. 2014;11:11
Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release
Gliga AR; Skoglund S; Wallinder IO; Fadeel B; Karlsson HL
Article: TOXICOLOGY LETTERS. 2014;224(2):196-200
Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: Role of pro-apoptotic Bid
Zaman F; Chrysis D; Huntjens K; Chagin A; Takigawa M; Fadeel B; Savendahl L
Journal article: BIOMATERIALIEN: OFFIZIELLES ORGAN DER DEUTSCHEN GESELLSCHAFT FUER BIOMATERIALIEN. 2013;14(3-4):195-216
The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design
Lynch I; Ahluwalia A; Boraschi D; Byrne HJ; Fadeel B; Gehr P; Gutleb AC; Kendall M; Papadopoulos MG
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Applying quantitative structure-activity relationship approaches to nanotoxicology: Current status and future potential
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Article: CELL BIOCHEMISTRY AND BIOPHYSICS. 2013;67(2):461-476
Oxidative Stress and Dermal Toxicity of Iron Oxide Nanoparticles In Vitro
Murray AR; Kisin E; Inman A; Young S-H; Muhammed M; Burks T; Uheida A; Tkach A; Waltz M; Castranova V; Fadeel B; Kagan VE; Riviere JE; Monteiro-Riviere N; Shvedova AA
Article: JOURNAL OF IMMUNOLOGY. 2013;191(5):2647-2656
Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process
Farrera C; Fadeel B
Article: SMALL. 2013;9(16):2721-2720
Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase
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Article: SMALL. 2013;9(9-10):1686-1690
Graphene Oxide, But Not Fullerenes, Targets Immunoproteasomes and Suppresses Antigen Presentation by Dendritic Cells
Tkach AV; Yanamala N; Stanley S; Shurin MR; Shurin GV; Kisin ER; Murray AR; Pareso S; Khaliullin T; Kotchey GP; Castranova V; Mathur S; Fadeel B; Star A; Kagan VE; Shvedova AA
Article: PLOS ONE. 2013;8(7):e68415
Gene Expression Profiling of Immune-Competent Human Cells Exposed to Engineered Zinc Oxide or Titanium Dioxide Nanoparticles
Tuomela S; Autio R; Buerki-Thurnherr T; Arslan O; Kunzmann A; Andersson-Willman B; Wick P; Mathur S; Scheynius A; Krug HF; Fadeel B; Lahesmaa R
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NanoMiner - Integrative Human Transcriptomics Data Resource for Nanoparticle Research
Kong L; Tuomela S; Hahne L; Ahlfors H; Yli-Harja O; Fadeel B; Lahesmaa R; Autio R
Article: MOLECULAR PHARMACOLOGY. 2013;83(1):245-255
Requirement of Apoptotic Protease-Activating Factor-1 for Bortezomib-Induced Apoptosis but Not for Fas-Mediated Apoptosis in Human Leukemic Cells
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Article: ACTA PAEDIATRICA. 2013;102(1):78-82
Ovarian failure in HAX1-deficient patients: is there a gender-specific difference in pubertal development in severe congenital neutropenia or Kostmann disease?
Carlsson G; Kristrom B; Nordenskjold M; Henter J-I; Fadeel B
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2012;158(3):363-369
Incidence of severe congenital neutropenia in Sweden and risk of evolution to myelodysplastic syndrome/leukaemia
Carlsson G; Fasth A; Berglof E; Lagerstedt-Robinson K; Nordenskjold M; Palmblad J; Henter J-I; Fadeel B
Article: CANCER LETTERS. 2012;319(2):232-241
Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition
Kimbung S; Biskup E; Johansson I; Aaltonen K; Ottosson-Wadlund A; Gruvberger-Saal S; Cunliffe H; Fadeel B; Loman N; Berglund P; Hedenfalk I
Article: PARTICLE AND FIBRE TOXICOLOGY. 2012;9:16
Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii
Swedin L; Arrighi R; Andersson-Willman B; Murray A; Chen Y; Karlsson MCI; Georen SK; Tkach AV; Shvedova AA; Fadeel B; Barragan A; Scheynius A
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Adsorption of Surfactant Lipids by Single-Walled Carbon Nanotubes in Mouse Lung upon Pharyngeal Aspiration
Kapralov AA; Feng WH; Amoscato AA; Yanamala N; Balasubramanian K; Winnica DE; Kisin ER; Kotchey GP; Gou P; Sparvero LJ; Ray P; Mallampalli RK; Klein-Seetharaman J; Fadeel B; Star A; Shvedova AA; Kagan VE
Article: PARTICLE AND FIBRE TOXICOLOGY. 2012;9:10
Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos
Murray AR; Kisin ER; Tkach AV; Yanamala N; Mercer R; Young S-H; Fadeel B; Kagan VE; Shvedova AA
Article: ACS NANO. 2012;6(3):1925-1938
Microsomal Glutathione Transferase 1 Protects Against Toxicity Induced by Silica Nanoparticles but Not by Zinc Oxide Nanoparticles
Shi J; Karlsson HL; Johansson K; Gogvadze V; Xiao L; Li J; Burks T; Garcia-Bennett A; Uheida A; Muhammed M; Mathur S; Morgenstern R; Kagan VE; Fadeel B
Article: FEBS LETTERS. 2012;586(6):747-752
Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis
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Article: BIOMATERIALS. 2012;33(7):1970-1981
Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers
Feliu N; Walter MV; Montanez MI; Kunzmann A; Hult A; Nystrom A; Malkoch M; Fadeel B
Article: NANOMEDICINE. 2012;7(3):327-334
Morphological properties of nanoporous folic acid materials and in vitro assessment of their biocompatibility
Zhou C; Kunzmann A; Rakonjac M; Fadeel B; Garcia-Bennett A
Article: AMERICAN JOURNAL OF PATHOLOGY. 2012;180(2):457-472
Differentiation-Promoting Culture of Competent and Noncompetent Keratinocytes Identifies Biomarkers for Head and Neck Cancer
Ceder R; Haig Y; Merne M; Hansson A; Zheng X; Roberg K; Nees M; Iljin K; Bloor BK; Morgan PR; Fadeel B; Grafstrom RC
Article: JOURNAL OF POLYMER SCIENCE. 2012;50(2):217-226
Linear-Dendritic Polymeric Amphiphiles as Carriers of Doxorubicin-In Vitro Evaluation of Biocompatibility and Drug Delivery
Wu Z; Zeng X; Zhang Y; Feliu N; Lundberg P; Fadeel B; Malkoch M; Nystrom AM
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Clear and present danger? Engineered nanoparticles and the immune system
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Article: PLOS ONE. 2012;7(3):e30923
Impaired Clearance and Enhanced Pulmonary Inflammatory/Fibrotic Response to Carbon Nanotubes in Myeloperoxidase-Deficient Mice
Shvedova AA; Kapralov AA; Feng WH; Kisin ER; Murray AR; Mercer RR; St Croix CM; Lang MA; Watkins SC; Konduru NV; Allen BL; Conroy J; Kotchey GP; Mohamed BM; Meade AD; Volkov Y; Star A; Fadeel B; Kagan VE
Article: PLOS ONE. 2012;7(3):e33168
Ablation of the Pro-Apoptotic Protein Bax Protects Mice from Glucocorticoid-Induced Bone Growth Impairment
Zaman F; Chrysis D; Huntjens K; Fadeel B; Savendahl L
Article: PLOS ONE. 2012;7(10):e47328
AIF and Scythe (Bat3) Regulate Phosphatidylserine Exposure and Macrophage Clearance of Cells Undergoing Fas (APO-1)-Mediated Apoptosis
Preta G; Fadeel B
Article: PLOS ONE. 2012;7(9):e46001
MAML1 Acts Cooperatively with EGR1 to Activate EGR1-Regulated Promoters: Implications for Nephrogenesis and the Development of Renal Cancer
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Article: BLOOD. 2011;118(22):5783-5793
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Meeths M; Chiang SCC; Wood SM; Entesarian M; Schlums H; Bang B; Nordenskjold E; Bjorklund C; Jakovljevic G; Jazbec J; Hasle H; Holmqvist B-M; Rajic L; Pfeifer S; Rosthoj S; Sabel M; Salmi TT; Stokland T; Winiarski J; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I; Bryceson YT
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Mapping the Surface Adsorption Forces of Nanomaterials in Biological Systems
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Journal article: CURRENT PEDIATRIC REVIEWS. 2011;7(4):301-309
Double-Edged Sword of Novel Anti-Cancer Treatment: Proteasome Inhibition in the Growth Plate Causes Impairment of Longitudinal Bone Growth
Zaman F; Fadeel B; Savendahl L
Article: ACS NANO. 2011;5(9):7342-7353
Global Phospholipidomics Analysis Reveals Selective Pulmonary Peroxidation Profiles upon Inhalation of Single-Walled Carbon Nanotubes
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Article: ACS NANO. 2011;5(8):6315-6324
Water-Soluble Superparamagnetic Magnetite Nanoparticles with Biocompatible Coating for Enhanced Magnetic Resonance Imaging
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Article: ARTHRITIS & RHEUMATOLOGY. 2011;63(8):2209-2214
Late-Onset Neutropenia Following Rituximab Therapy in Rheumatic Diseases: Association With B Lymphocyte Depletion and Infections
Tesfa D; Ajeganova S; Hagglund H; Sander B; Fadeel B; Hafstrom I; Palmblad J
Article: ACS NANO. 2011;5(7):5755-5762
Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure
Tkach AV; Shurin GV; Shurin MR; Kisin ER; Murray AR; Young S-H; Star A; Fadeel B; Kagan VE; Shvedova AA
Article: ACS NANO. 2011;5(7):5312-5324
Solution-Engineered Palladium Nanoparticles: Model for Health Effect Studies of Automotive Particulate Pollution
Wilkinson KE; Palmberg L; Witasp E; Kupczyk M; Feliu N; Gerde P; Seisenbaeva GA; Fadeel B; Dahlen S-E; Kessler VG
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2011;253(2):81-93
Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells
Kunzmann A; Andersson B; Vogt C; Feliu N; Ye F; Gabrielsson S; Toprak MS; Buerki-Thurnherr T; Laurent S; Vahter M; Krug H; Muhammed M; Scheynius A; Fadeel B
Article: BIOCHEMICAL PHARMACOLOGY. 2011;81(8):976-984
In search of the Holy Grail: Folate-targeted nanoparticles for cancer therapy
Garcia-Bennett A; Nees M; Fadeel B
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2011;252(1):1-10
Genotoxicity of carbon nanofibers: Are they potentially more or less dangerous than carbon nanotubes or asbestos?
Kisin ER; Murray AR; Sargent L; Lowry D; Chirila M; Siegrist KJ; Schwegler-Berry D; Leonard S; Castranova V; Fadeel B; Kagan VE; Shvedova AA
Article: PEDIATRIC BLOOD & CANCER. 2011;56(3):444-451
Hematopoietic Stem Cell Transplantation in Severe Congenital Neutropenia
Carlsson G; Winiarski J; Ljungman P; Ringden O; Mattsson J; Nordenskjold M; Touw I; Henter J-I; Palmblad J; Fadeel B; Hagglund H
Article: NANOSCALE. 2010;2(12):2514-2520
Nanotoxicology: no small matter
Feliu N; Fadeel B
Article: MOLECULAR IMMUNOLOGY. 2010;47(14):2388-2396
The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells
Feng X; Yan J; Wang Y; Zierath JR; Nordenskjold M; Henter J-I; Fadeel B; Zheng C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):7-10
Programmed cell clearance: Molecular regulation of the elimination of apoptotic cell corpses and its role in the resolution of inflammation
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Article: PEDIATRIC BLOOD & CANCER. 2010;54(4):563-572
Clinical Presentation of Griscelli Syndrome Type 2 and Spectrum of RAB27A Mutations
Meeths M; Bryceson YT; Rudd E; Zheng C; Wood SM; Ramme K; Beutel K; Hasle H; Heilmann C; Hultenby K; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2009;241(3):260-268
Size-dependent effects of tungsten carbide-cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells
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Article: PEDIATRIC BLOOD & CANCER. 2009;53(6):1143-1146
Compound Heterozygous HAX1 Mutations in a Swedish Patient With Severe Congenital Neutropenia and No Neurodevelopmental Abnormalities
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N^α-Tosyl-L-phenylalanine Chloromethyl Ketone Induces Caspase-dependent Apoptosis in Transformed Human B Cell Lines with Transcriptional Down-regulation of Anti-apoptotic HS1-associated Protein X-1
Jitkaew S; Trebinska A; Grzybowska E; Carlsson G; Nordstrom A; Lehtio J; Frojmark A-S; Dahl N; Fadeel B
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Efficient internalization of mesoporous silica particles of different sizes by primary human macrophages without impairment of macrophage clearance of apoptotic or antibody-opsonized target cells
Witasp E; Kupferschmidt N; Bengtsson L; Hultenby K; Smedman C; Paulie S; Garcia-Bennett AE; Fadeel B
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2009;297(3):C621-C631
Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease
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Article: INHALATION TOXICOLOGY. 2009;21 Suppl 1:131-136
Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses.
Witasp E; Shvedova AA; Kagan VE; Fadeel B
Journal article: PLOS ONE. 2009;4(5):10.1371/annotation/1801d3
Correction: Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo
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Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity
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Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2009;85(3):427-437
Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: role in macrophage recognition and engulfment
Jitkaew S; Witasp E; Zhang S; Kagan VE; Fadeel B
Article: PLOS ONE. 2009;4(2):e4398
Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo
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[Langerhans cell histiocytosis: new light over pathogenesis. 75 years since Sture Siwe's classic work on "systemic reticuloendotheliosis"].
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Article: FEBS LETTERS. 2008;582(23-24):3501-3508
Brief cross-linking of Fas/APO-1 (CD95) triggers engulfment of pre-apoptotic target cells
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Article: JOURNAL OF INTERNAL MEDICINE. 2008;264(4):388-400
Central nervous system involvement in severe congenital neutropenia:: neurological and neuropsychological abnormalities associated with specific HAX1 mutations
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Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2008;231(2):235-240
Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
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Article: PEDIATRIC BLOOD & CANCER. 2008;51(1):76-81
Incidence of Langerhans cell histiocytosis in children:: A population-based study
Stalemark H; Laurencikas E; Karis J; Gavhed D; Fadeel B; Henter J-I
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2008;142(3):469-479
Syntaxin-11 is expressed in primary human monocytes/macrophages and acts as a negative regulator of macrophage engulfment of apoptotic cells and IgG-opsonized target cells
Zhang S; Ma D; Wang X; Celkan T; Nordenskjoeld M; Henter J-I; Fadeel B; Zheng C
Journal article: CURRENT IMMUNOLOGY REVIEWS. 2008;4(2):53-69
PROGRAMMED Cell Clearance: Molecular Mechanisms and Role in Autoimmune Disease, Chronic Inflammation, and Anti-Cancer Immune Responses
Witasp E; Kagan V; Fadeel B
Article: PEDIATRIC BLOOD & CANCER. 2008;50(5):1067-1069
Sequence analysis of the SRGN, AP3B1, ARF6, and SH2D1A genes in familial hemophagocytic lymphohistiocytosis
Ma D; Rudd E; Edner J; Gavhed S; Ramme KG; Fadeel B; Nordenskjoeld M; Henter J-I; Zheng C
Article: JOURNAL OF MEDICAL GENETICS. 2008;45(3):134-141
Spectrum, and clinical and functional implications of UNC13D mutations in familial haemophagocytic lymphohistiocytosis
Rudd E; Bryceson YT; Zheng C; Edner J; Wood SM; Ramme K; Gavhed S; Gurgey A; Hellebostad M; Bechensteen AG; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I
Article: MEDICAL ONCOLOGY. 2008;25(4):374-379
Late-onset neutropenia associated with rituximab therapy: evidence for a maturation arrest at the (pro)myelocyte stage of granulopoiesis
Tesfa D; Gelius T; Sander B; Kimby E; Fadeel B; Palmblad J; Hagglund H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;363(4):989-993
VEGF reduces astrogliosis and preserves neuromuscular junctions in ALS transgenic mice
Zheng C; Skold MK; Li J; Nennesmo I; Fadeel B; Henter J-I
Article: HFSP JOURNAL. 2007;1(4):225-229
Fat(al) attraction: oxidized lipids act as "eat-me" signals
Fadeel B; Quinn P; Xue D; Kagan V
Article: CANCER RESEARCH. 2007;67(20):10078-10086
Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice
Zaman F; Menendez-Benito V; Eriksson E; Chagin AS; Takigawa M; Fadeel B; Dantuma NP; Chrysis D; Saevendahl L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;360(1):263-268
Epstein-Barr virus-encoded LMP1 promotes cisplatin-induced caspase activation through JNK and NF-κB signaling pathways
Zhang X; Sanmun D; Hu L; Fadeel B; Ernberg I
Article: LEUKEMIA. 2007;21(5):1035-1043
Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent
Sun Y; Ottosson A; Pervaiz S; Fadeel B
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2007;137(2):166-169
Low plasma levels of the protein pro-LL-37 as an early indication of severe disease in patients with chronic neutropenia
Karlsson J; Carlsson G; Ramme KG; Hagglund H; Nordenskjold M; Henter J-I; Palmblad J; Putsep K; Andersson M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(11):8498-8509
Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment - Implications for the resolution of inflammation
Tyurina YY; Basova LV; Konduru NV; Tyurin VA; Potapovich AI; Cai P; Bayir H; Stoyanovsky D; Pitt BR; Shvedova AA; Fadeel B; Kagan VE
Article: CLINICAL IMMUNOLOGY. 2007;122(3):349-355
Normal levels of constitutive and death receptor-mediated apoptosis of peripheral blood neutrophils from patients with chronic idiopathic neutropenia
Garwicz D; Palmblad J; Fadeel B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;353(3):571-575
Assignment of the gene locus for severe congenital neutropenia to chromosome 1q22 in the original Kostmann family from Northern Sweden
Melin M; Entesarian M; Carlsson G; Garwicz D; Klein C; Fadeel B; Nordenskjold M; Palmblad J; Henter JI; Dahl N
Article: NATURE GENETICS. 2007;39(1):86-92
HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)
Klein C; Grudzien M; Appaswamy G; Germeshausen M; Sandrock I; Schaffer AA; Rathinam C; Boztug K; Schwinzer B; Rezaei N; Bohn G; Melin M; Carlsson G; Fadeel B; Dahl N; Palmblad J; Henter J-I; Zeidler C; Grimbacher B; Welte K
Article: LAKARTIDNINGEN. 2006;103(50-52):4022-4027
[Kostmann's syndrome largely elucidated--by Swedish research. 50 years since Rolf Kostmann's pioneering work on severe congenital neutropenia].
Carlsson G; Garwicz D; Nordenskjöld M; Fadeel B; Palmblad J; Henter J-I
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2006;134(6):640-644
Stromal-derived factor-1 abolishes constitutive apoptosis of WHIM syndrome neutrophils harbouring a truncating CXCR4 mutation
Sanmun D; Garwicz D; Smith CIE; Palmblad J; Fadeel B
Article: HAEMATOLOGICA. 2006;91(5):589-595
Neutrophil elastase and granulocyte colony-stimulating factor receptor mutation analyses and leukemia evolution in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden
Carlsson G; Aprikyan AAG; Ericson KG; Stein S; Makaryan V; Dale DC; Nordenskjold M; Fadeel B; Palmblad J; Hentera J-I
Article: JOURNAL OF MEDICAL GENETICS. 2006;43(4):e14
Spectrum and clinical implications of syntaxin 11 gene mutations in familial haemophagocytic lymphohistiocytosis:: association with disease-free remissions and haematopoietic malignancies -: art. no. e14
Rudd E; Ericson KG; Zheng C; Uysal Z; Özkan A; Gürgey A; Fadeel B; Nordenskjöld M; Henter JI
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2006;28(3):605-617
Combined spectral karyotyping, comparative genomic hybridization, and in vitro apoptyping of a panel of Burkitt's lymphoma-derived B cell lines reveals an unexpected complexity of chromosomal aberrations and a recurrence of specific abnormalities in chemoresistant cell lines
Karpova MB; Schoumans J; Blennow E; Ernberg I; Henter JI; Smirnov AF; Nordenskjöld M; Fadeel B
Article: CELL DEATH AND DIFFERENTIATION. 2006;13(3):360-362
PS externalization: from corpse clearance to drug delivery
Fadeel B; Xue D
Article: PEDIATRIC RESEARCH. 2006;59(2):281-286
Elevated serum levels of the decoy receptor osteoprotegerin in children with langerhans cell histiocytosis
Rosso DA; Karis J; Braier JL; Henter JI; Fadeel B
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(1):246-252
Betulinic acid, a natural cytotoxic agent, fails to trigger apoptosis in human Burkitt's lymphoma-derived B-cell lines
Karpova MB; Sanmun D; Henter JI; Smirnov AF; Fadeel B
Article: CLINICAL CANCER RESEARCH. 2005;11(17):6291-6299
Antiapoptotic role of growth factors in the Myelodysplastic syndromes: Concordance between in vitro and in vivo observations
Tehranchi R; Fadeel B; Schmidt-Mende J; Forsblom AM; Emanuelsson E; Jadersten M; Christensson B; Hast R; Howe RB; Samuelsson J; Zhivotovsky B; Hollström-Lindberg E
Article: BLOOD. 2005;106(1):247-253
Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes
Tehranchi R; Invernizzi R; Grandien A; Zhivotovsky B; Fadeel B; Forsblom AM; Travaglino E; Samuelsson J; Hast R; Nilsson L; Cazzola M; Wibom R; Hellström-Lindberg E
Article: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. 2005;27(6):301-306
Immunohistochemical detection of the apoptosis-related proteins FADD, FLICE, and FLIP in langerhans cell histiocytosis
Bank MI; Gudbrand C; Rengtved P; Carstensen H; Fadeel B; Henter JI; Petersen BL
Article: BLOOD. 2005;105(10):4070-4077
Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance
Sun Y; Orrenius S; Pervaiz S; Fadeel B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;330(3):891-897
Vitamin D fails to prevent serum starvation- or staurosporine-induced apoptosis in human and rat osteosarcoma-derived cell lines
Witasp E; Gustafsson AC; Cotgreave I; Lind M; Fadeel B
Article: LAKARTIDNINGEN. 2005;102(18-19):1444-1446
[Enigmatic diseases in children. Still a lot of questions left in spite of great research progress on LCH and HLH].
Fadeel B; Trottestam H; Löfstedt M; Gavhed D; Henter J-I
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;113(3):397-405
Epstein-Barr virus-encoded latent membrane protein 1 promotes stress-induced apoptosis upstream of caspase-2-dependent mitochondrial perturbation
Zhang XN; Uthaisang W; Hu LF; Ernberg IT; Fadeel B
Article: ANNALS OF NEUROLOGY. 2004;56(4):564-567
Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS
Zheng CY; Nennesmo I; Fadeel B; Henter JI
Article: BLOOD. 2004;104(6):1859-1866
An endothelial laminin isoform, laminin 8 (α4β1γ1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis
Wondimu Z; Geberhiwot T; Ingerpuu S; Juronen E; Xie X; Lindbom L; Doi M; Kortesmaa J; Thyboll J; Tryggvason K; Fadeel B; Patarroyo M
Article: CANCER LETTERS. 2004;208(2):171-178
VR-3848, a novel peptide derived from Euphobiaceae, induces mitochondria-dependent apoptosis in human leukemia cells
Uthaisang W; Reutrakul V; Krachangchaeng C; Wilairat P; Fadeel B
Article: BLOOD. 2004;103(9):3355-3361
Kostmann syndrome:: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells
Carlsson G; Aprikyan AAG; Tehranchi R; Dale DC; Porwit A; Hellström-Lindberg E; Palmblad J; Henter JI; Fadeel B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(7):6056-6064
Lipid antioxidant, etoposide, inhibits phosphatidylserine externalization and macrophage clearance of apoptotic cells by preventing phosphatidylserine oxidation
Tyurina YY; Serinkan FB; Tyurin VA; Kini V; Yalowich JC; Schroit AJ; Fadeel B; Kagan VE
Article: FASEB JOURNAL. 2004;18(1):1-4
Buried alive: a novel approach to cancer treatment
Fadeel B; Orrenius S; Pervaiz S
Article: FEBS LETTERS. 2003;545(2-3):110-114
Phosphatidylserine exposure in Fas type I cells is mitochondria-dependent
Uthaisang W; Nutt LK; Orrenius S; Fadeel B
Article: BLOOD. 2003;101(3):1080-1086
Granulocyte colony-stimulating factor inhibits spontaneous cytochrome c release and mitochondria-dependent apoptosis of myelodysplastic syndrome hematopoietic progenitors
Tehranchi R; Fadeel B; Forsblom AM; Christensson B; Samuelsson J; Zhivotovsky B; Hellstrom-Lindberg E
Article: HUMAN GENETICS. 2003;112(1):98-99
Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis
Ericson KG; Fadeel B; Andersson M; Gudmundsson GH; Gürgey A; Yalman N; Janka G; Nordenskjöld M; Henter JI
Article: VIROLOGY. 2002;304(2):330-341
Apoptosis modulation of Epstein-Barr virus-encoded latent membrane protein 1 in the epithelial cell line HeLa is stimulus-dependent
Zhang XN; Hu LF; Fadeel B; Ernberg IT
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(51):49965-49975
NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me₂SO-differentiated HL-60 cells -: Role in phagocytic clearance
Arroyo A; Modriansky M; Serinkan FB; Bello RI; Matsura T; Jiang JF; Tyurin VA; Tyurina YY; Fadeel B; Kagan VE
Article: JOURNAL OF IMMUNOLOGY. 2002;169(1):487-499
A role for oxidative stress in apoptosis:: Oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis
Kagan VE; Gleiss B; Tyurina YY; Tyurin VA; Elenström-Magnusson C; Liu SX; Serinkan FB; Arroyo A; Chandra J; Orrenius S; Fadeel B
Article: FEBS LETTERS. 2002;519(1-3):153-158
Fas-triggered phosphatidylserine exposure is modulated by intracellular ATP
Gleiss B; Gogvadze V; Orrenius S; Fadeel B
Article: LAKARTIDNINGEN. 2001;98(42):4613-4614
[Apoptosis--emperor's new clothes?].
Fadeel B
Article: LEUKEMIA. 2001;15(5):742-751
Granulocyte colony-stimulating factor inhibits Fas-triggered apoptosis in bone marrow cells isolated from patients with refractory anemia with ringed sideroblasts
Schmidt-Mende J; Tehranchi R; Forsblom AM; Joseph B; Christensson B; Fadeel B; Zhivotovsky B; Hellström-Lindberg E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2001;112(3):714-726
Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases
Lindberg EH; Schmidt-Mende J; Forsblom AM; Christensson B; Fadeel B; Zhivotovsky B
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2001;68(3):590-597
Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis
Ericson KG; Fadeel B; Nilsson-Ardnor S; Söderhäll C; Samuelsson A; Janka G; Schneider M; Gürgey A; Yalman N; Révész T; Egeler RM; Jahnukainen K; Storm-Mathiesen I; Haraldsson A; Poole J; de Saint Basile G; Nordenskjöld M; Henter JI
Article: MEDICAL PRINCIPLES AND PRACTICE. 2000;9(3):151-163
The potential role of apoptosis in human disease
Fadeel B; Orrenius S; Zhivotovsky B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;266(2):504-511
Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression
Fadeel B; Gleiss B; Högstrand K; Chandra J; Wiedmer T; Sims PJ; Henter JI; Orrenius S; Samali A
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1999;106(2):406-415
Induction of apoptosis and caspase activation in cells obtained from familial haemophagocytic lymphohistiocytosis patients
Fadeel B; Orrenius S; Henter JI
Article: EXPERIMENTAL HEMATOLOGY. 1999;27(8):1322-1329
Two pathways of apoptosis induced with all-trans retinoic acid and etoposide in the myeloid cell line P39
Hassan Z; Fadeel B; Zhivotovsky B; Hellström-Lindberg E
Article: LEUKEMIA. 1999;13(5):719-728
Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells
Fadeel B; Hassan Z; Hellström-Lindberg E; Henter JI; Orrenius S; Zhivotovsky B
Journal article: BLOOD. 1998;92(12):4808-4818
Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species
Fadeel B; Åhlin A; Henter J-I; Orrenius S; Hampton MB
Article: BLOOD. 1998;92(12):4808-4818
Involvement of caspases in neutrophil apoptosis: Regulation by reactive oxygen species
Fadeel B; Åhlin A; Henter JI; Orrenius S; Hampton MB
Article: INTERNATIONAL IMMUNOLOGY. 1998;10(2):131-140
A three-dimensional model of the Fas/APO-1 molecule: cross-reactivity of anti-Fas antibodies explained by structural mimicry of antigenic sites
Fadeel B; Lindberg J; Achour A; Chiodi F
Article: AIDS. 1997;11(10):1219-1225
Induction of apoptosis by primary HIV-1 isolates correlates with productive infection in peripheral blood mononuclear cells
Zhang YJ; Fadeel B; Hodara V; Fenyo EM
Article: INTERNATIONAL IMMUNOLOGY. 1997;9(2):201-209
Anti-Fas IgG1 antibodies recognizing the same epitope of Fas/APO-1 mediate different biological effects in vitro
Fadeel B; Thorpe CJ; Yonehara S; Chiodi F
Article: INTERNATIONAL IMMUNOLOGY. 1995;7(12):1967-1975
Mapping of the linear site on the Fas/APO-1 molecule targeted by the prototypic anti-Fas mAb
Fadeel B; Thorpe CJ; Chiodi F
Journal article: REVIEWS IN MEDICAL VIROLOGY. 1995;5(2):105-119
HIV‐1 Infection of the brain: Which pathogenic mechanisms are relevant for tissue damage?
Elovaara I; Fadeel B; Chiodi F
Journal article: VIROLOGY. 1993;196(2):475-483
V3 SEQUENCES OF PAIRED HIV-1 ISOLATES FROM BLOOD AND CEREBROSPINAL-FLUID CLUSTER ACCORDING TO HOST AND SHOW VARIATION RELATED TO THE CLINICAL STAGE OF DISEASE
KEYS B; KARIS J; FADEEL B; VALENTIN A; NORKRANS G; HAGBERG L; CHIODI F
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Professor, Institutet för miljömedicin, Karolinska Institutet, 2010-

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Docent, Toxikologi, Karolinska Institutet, 2004
Leg. Läkare, Karolinska University Hospital, 2001
MEDICINE DOKTORSEXAMEN, Institutet för miljömedicin, Karolinska Institutet, 1999
Läkarexamen, Karolinska Institutet, 1997

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