We study the distribution and elimination of infusion fluids during surgery and intensive care in relation to haemodynamics, microcirculation and complications. We have devised and developed volume kinetics, an adaptation of pharmacokinetics for infusion fluids, to describe pathological fluid distribution and third-space effects. A key focus over the past decade has been studies into the clinical use of 20% albumin. The group is internationally composed.
The research group investigates how infusion fluids act in the body during surgery and intensive care; in particular, we study how fluids affect blood circulation, microcirculation and complications. The group has also developed volume kinetics, a method for understanding how fluid is distributed throughout the body.
The research team has conducted 10 studies on the use of 20% albumin in different settings during the past decade. Current efforts include the use of albumin 5%, 20%, and Ringer's solution for goal-directed fluid therapy during major laparoscopic surgery (with Robert Svensson, Norrköping, and Joachim Zdolsek, Linköping) and albumin 20% for hemodynamic stability in frail surgical patients (with Patrick Wuethrich, Bern).
Evaluation of a patented invention by which blood flows are quantified by transdermal administration and measurement of tracer amounts of nitrous oxide.
Third-space effects of infusion fluids in overload and inflammatory states (with Randal Dull, USA). Volume kinetics of Gelofusine and sepsis (with Cosmin Balan, Romania). Volume kinetics in veterinary science, cats and horses (with Shane Bateman, William Muir and Xiu Ting Yiew, Canada). Sublingual microcirculation versus volume kinetics (with David Astapenko, Czech Republic).
We study relationships between stressed and unstressed blood volume, stroke volume, and mean systemic pressure during bolus administration of fluid (with Terry O´Brien, UK).
Factors influencing urine flow during vascular surgery performed under spinal anesthesia (with Cosmin Balan, Romania) and the relationships between of concentrated urine before surgery, urine flow during surgery, and the development of acute kidney injury (with Yuhong Li, PR of China).
