Epigenetik och cellulär plasticitet vid utveckling av barncancer – Sander Lambos team

Vår forskning fokuserar på att identifiera epigenetiska mönster som driver uppkomst och utveckling av barncancer. Med avancerade sekvenseringsmetoder, inklusive DNA-metyleringsanalys på encellsnivå, studerar vi tumörers epigenetiska heterogenitet och cellulära plasticitet. Genom att analysera och påverka dessa mönster undersöker vi bakomliggande mekanismer och utvecklar maskininlärningsbaserade biomarkörer för framtida diagnostik och behandling.

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Publikationer

Alla gruppmedlemmars publikationer

  • Article: BLOOD. 2025;146(25):3019-3035
    Fleming TJ; Antoszewski M; Lambo S; Gundry MC; Piussi R; Wahlster L; Shah S; Reed FE; Dong KD; Paulo JA; Gygi SP; Mimoso C; Goldman SR; Adelman K; Perry JA; Pikman Y; Stegmaier K; Barrachina MN; Machlus KR; Hovestadt V; Arruda A; Minden MD; Voit RA; Sankaran VG
  • Letter: HEMASPHERE. 2025;9(9):e70212
    Koedijk JB; Barneh F; Meesters-Ensing JI; van Tuil M; Sonneveld E; Lambo S; Perzolli A; Schweighart EK; Blanco MNF; van der Meulen M; Deli A; Haasjes E; Christensen KB; de Groot-Kruseman HA; Meshinchi S; Hasle H; Belderbos ME; Luesink M; Goemans BF; Nierkens S; Hehir-Kwa J; Zwaan CM; Heidenreich O
  • Preprint: BIORXIV. 2025;BIORXIV
    Schneider C; Alexe G; Merickel LA; Meyer A; Swift ML; Serafim RB; Basanthakumar AT; Taillon A; Salhotra S; Boniolo F; Lambo S; Rodriguez Y; Häupl B; George RE; Root DE; Oellerich T; Hovestadt V; Chowdhury D; Stegmaier K
  • Article: NATURE CANCER. 2025;6(6):1035-1055
    Beck A; Gabler-Pamer L; Alencastro Veiga Cruzeiro G; Lambo S; Englinger B; Shaw ML; Hack OA; Liu I; Haase RD; de Biagi Jr CAO; Baumgartner A; Nascimento Silva AD; Klenner M; Freidel PS; Herms J; von Baumgarten L; Tonn JC; Thon N; Bruckner K; Madlener S; Mayr L; Senfter D; Peyrl A; Slavc I; Loetsch D; Dorfer C; Geyregger R; Amberg N; Haberler C; Mack N; Schwalm B; Pfister SM; Korshunov A; Baird LC; Yang E; Chi SN; Alexandrescu S; Gojo J; Kool M; Hovestadt V; Filbin MG
  • Preprint: BIORXIV. 2025
    Koedijk J; Barneh F; Meesters-Ensing J; van Tuil M; Sonneveld E; Lambo S; Perzolli A; Schweighart E; Ferrao Blanco M; van der Meulen M; Deli A; Haasjes E; Christensen KB; de Groot-Kruseman H; Meshinchi S; Hasle H; Belderbos M; Luesink M; Goemans B; Nierkens S; Hehir-Kwa J; Zwaan M; Heidenreich O
  • Preprint: BLOOD. 2024
    Fleming TJ; Antoszewski M; Lambo S; Gundry MC; Piussi R; Wahlster L; Shah S; Reed FE; Dong KD; Paulo JA; Gygi SP; Mimoso C; Goldman SR; Adelman K; Perry JA; Pikman Y; Stegmaier K; Barrachina MN; Machlus KR; Hovestadt V; Arruda A; Minden MD; Voit RA; Sankaran VG
  • Article: CANCER CELL. 2023;41(12):2117-2135.e12
    Lambo S; Trinh DL; Ries RE; Jin D; Setiadi A; Ng M; Leblanc VG; Loken MR; Brodersen LE; Dai F; Pardo LM; Ma X; Vercauteren SM; Meshinchi S; Marra MA
  • Article: GENOME MEDICINE. 2023;15(1):67
    Nabbi A; Beck P; Delaidelli A; Oldridge DA; Sudhaman S; Zhu K; Yang SYC; Mulder DT; Bruce JP; Paulson JN; Raman P; Zhu Y; Resnick AC; Sorensen PH; Sill M; Brabetz S; Lambo S; Malkin D; Johann PD; Kool M; Jones DTW; Pfister SM; Jaeger N; Pugh TJ
  • Article: FRONTIERS IN ONCOLOGY. 2020;10:584681
    Mayr L; Gojo J; Peyrl A; Azizi AA; Stepien NM; Pletschko T; Czech T; Dorfer C; Lambo S; Dieckmann K; Haberler C; Kool M; Slavc I
  • Review: ACTA NEUROPATHOLOGICA. 2020;140(3):249-266
    Lambo S; von Hoff K; Korshunov A; Pfister SM; Kool M
  • Article: NATURE. 2019;576(7786):274-280
    Lambo S; Groebner SN; Rausch T; Waszak SM; Schmidt C; Gorthi A; Romero JC; Mauermann M; Brabetz S; Krausert S; Buchhalter I; Koster J; Zwijnenburg DA; Sill M; Huebner J-M; Mack N; Schwalm B; Ryzhova M; Hovestadt V; Papillon-Cavanagh S; Chan JA; Landgraf P; Ho B; Milde T; Witt O; Ecker J; Sahm F; Sumerauer D; Ellison DW; Orr BA; Darabi A; Haberler C; Figarella-Branger D; Wesseling P; Schittenhelm J; Remke M; Taylor MD; Gil-da-Costa MJ; Lastowska M; Grajkowska W; Hasselblatt M; Hauser P; Pietsch T; Uro-Coste E; Bourdeaut F; Masliah-Planchon J; Rigau V; Alexandrescu S; Wolf S; Li X-N; Schuller U; Snuderl M; Karajannis MA; Giangaspero F; Jabado N; von Deimling A; Jones DTW; Korbel JO; von Hoff K; Lichter P; Huang A; Bishop AJR; Pfister SM; Korshunov A; Kool M
  • Article: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 2019;45(2):108-118
    Korshunov A; Casalini B; Chavez L; Hielscher T; Sill M; Ryzhova M; Sharma T; Schrimpf D; Stichel D; Capper D; Reuss DE; Sturm D; Absalyamova O; Golanov A; Lambo S; Bewerunge-Hudler M; Lichter P; Herold-Mende C; Wick W; Pfister SM; Kool M; Jones DTW; von Deimling A; Sahm F
  • Letter: ACTA NEUROPATHOLOGICA. 2019;137(1):175-177
    Uro-Coste E; Masliah-Planchon J; Siegfried A; Blanluet M; Lambo S; Kool M; Roujeau T; Boetto S; Palenzuela G; Bertozzi A-I; Gambart M; Coupier I; Oliver-Petit I; Golmard L; Julia S; Savagner F; Mohand-Oumoussa B; Tauziede-Espariat A; Delisle M-B; Figarella-Branger D; Bourdeaut F; Rigau V
  • Corrigendum: NATURE. 2018;559(7714):E10
    Groebner SN; Worst BC; Weischenfeldt J; Buchhalter I; Kleinheinz K; Rudneva VA; Johann PD; Balasubramanian GP; Segura-Wang M; Brabetz S; Bender S; Hutter B; Sturm D; Pfaff E; Huebschmann D; Zipprich G; Heinold M; Eils J; Lawerenz C; Erkek S; Lambo S; Waszak S; Blattmann C; Borkhardt A; Kuhlen M; Eggert A; Fulda S; Gessler M; Wegert J; Kappler R; Baumhoer D; Burdach S; Kirschner-Schwabe R; Kontny U; Kulozik AE; Lohmann D; Hettmer S; Eckert C; Bielack S; Nathrath M; Niemeyer C; Richter GH; Schulte J; Siebert R; Westermann F; Molenaar JJ; Vassal G; Witt H; Burkhardt B; Kratz CP; Witt O; van Tilburg CM; Kramm CM; Fleischhack G; Dirksen U; Rutkowski S; Fruehwald M; von Hoff K; Wolf S; Klingebiel T; Koscielniak E; Landgraf P; Koster J; Resnick AC; Zhang J; Liu Y; Zhou X; Waanders AJ; Zwijnenburg DA; Raman P; Brors B; Weber UD; Northcott PA; Pajtler KW; Kool M; Piro RM; Korbel JO; Schlesner M; Eils R; Jones DTW; Lichter P; Chavez L; Zapatka M; Pfister SM
  • Article: NATURE. 2018;555(7696):321-327
    Groebner SN; Worst BC; Weischenfeldt J; Buchhalter I; Kleinheinz K; Rudneva VA; Johann PD; Balasubramanian GP; Segura-Wang M; Brabetz S; Bender S; Hutter B; Sturm D; Pfaff E; Huebschmann D; Zipprich G; Heinold M; Eils J; Lawerenz C; Erkek S; Lambo S; Waszak S; Blattmann C; Borkhardt A; Kuhlen M; Eggert A; Fulda S; Gessler M; Wegert J; Kappler R; Baumhoer D; Burdach S; Kirschner-Schwabe R; Kontny U; Kulozik AE; Lohmann D; Hettmer S; Eckert C; Bielack S; Nathrath M; Niemeyer C; Richter GH; Schulte J; Siebert R; Westermann F; Molenaar JJ; Vassal G; Witt H; Burkhardt B; Kratz CP; Witt O; van Tilburg CM; Kramm CM; Fleischhack G; Dirksen U; Rutkowski S; Fruhwald M; von Hoff K; Wolf S; Klingebiel T; Koscielniak E; Landgraf P; Koster J; Resnick AC; Zhang J; Liu Y; Zhou X; Waanders AJ; Zwijnenburg DA; Raman P; Brors B; Weber UD; Northcott PA; Pajtler KW; Kool M; Piro RM; Korbel JO; Schlesner M; Eils R; Jones DTW; Lichter P; Chavez L; Zapatka M; Pfister SM
  • Article: NATURE MEDICINE. 2017;23(10):1191-1202
    Neumann JE; Wefers AK; Lambo S; Bianchi E; Bockstaller M; Dorostkar MM; Meister V; Schindler P; Korshunov A; von Hoff K; Nowak J; Warmuth-Metz M; Schneider MR; Renner-Mueller I; Merk DJ; Shakarami M; Sharma T; Chavez L; Glass R; Chan JA; Taketo MM; Neumann P; Kool M; Schueller U
  • Article: NATURE COMMUNICATIONS. 2017;8:14758
    Feng W; Kawauchi D; Koerkel-Qu H; Deng H; Serger E; Sieber L; Ariel Lieberman J; Jimeno-Gonzalez S; Lambo S; Hanna BS; Harim Y; Jansen M; Neuerburg A; Friesen O; Zuckermann M; Rajendran V; Gronych J; Ayrault O; Korshunov A; Jones DTW; Kool M; Northcott PA; Lichter P; Cortes-Ledesma F; Pfister SM; Liu H-K
  • Article: GENES CHROMOSOMES & CANCER. 2016;55(5):418-427
    Sahm F; Jakobiec FA; Meyer J; Schrimpf D; Eberhart CG; Hovestadt V; Capper D; Lambo S; Ryzhova M; Schueller U; Zheludkova O; Kumirova E; Lichter P; von Deimling A; Jones DTW; Pfister SM; Kool M; Korshunov A