Klas Wiman
Professor
| Docent
E-postadress: klas.wiman@ki.se
Besöksadress: BioClinicum, J6:10, Akademiska stråket 1, 17164 Solna
Postadress: K7 Onkologi-Patologi, K7 Forskning Wiman, 171 77 Stockholm
Om mig
- Jag är professor i molekylär cell- och tumörbiologi vid Karolinska Institutet sedan 1999. Mitt huvudintresse som forskare är cancer och ny cancerbehandling. I mer än tre decennier har jag forskat om tumörsuppressorgenen TP53. Jag har varit koordinator för ett EU Integrated project (Mutp53) med 23 partners och en budget på 8 miljoner Euro 2004-2009, och varit redaktör för två böcker om p53 (Springer 2005 och 2012). Jag grundade företaget Aprea Therapeutics tillsammans med kollegor för att utveckla nya p53-baserade cancerläkemedel. De senaste åren har jag varit innehavare av ett ERC Advanced Grant.
Utbildning
Med kand Uppsala Universitet 1977
Med doktor Uppsala Universitet 1981
Post doc Memorial Sloan-Kettering Cancer Center New York 1982-85
Läkarexamen Karolinska Institutet 1989
Forskningsbeskrivning
- Min forskargrupp bedriver forskning om p53 och p53-medierad tumörsuppression, den p53-reglerade genen Zmat3 (Wig-1), och reaktivering av muterat p53 som ny cancerterapi. Vi har identifierat molekylen APR-246 som kan utlösa apoptos i tumörceller med muterad TP53 och hämma tumörtillväxt in vivo i möss. Molekylen påverkar även redoxbalansen i celler. APR-246 har testats i flera kliniska studier i patienter med MDS/AML. Vi undersöker om APR-246 kan användas för cancerprevention. Vi arbetar också med utveckling av nya strategier för farmakologisk induktion av translationell genomläsning för att reaktivera nonsense-muterad TP53 i tumörer.
Utvalda publikationer
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Article: CELL DEATH & DISEASE. 2022;13(11):997
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Article: EMBO MOLECULAR MEDICINE. 2021;13(2):e10852
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Review: NATURE REVIEWS CANCER. 2018;18(2):89-102
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Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(29):3633-3639
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Article: CANCER CELL. 2009;15(5):376-388
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Review: CANCER CELL. 2007;12(4):303-312
Artiklar
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Article: RNA BIOLOGY. 2023;20(1):368-383
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Article: PLOS ONE. 2023;18(11):e0292468
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Article: CELL DEATH & DISEASE. 2022;13(3):214
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Article: CELL DEATH & DISEASE. 2021;12(7):709
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Article: CELL DEATH AND DIFFERENTIATION. 2021;28(5):1477-1492
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Article: CELL DEATH DISCOVERY. 2020;6(1):42
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Article: CLINICAL GENETICS. 2019;96(3):216-225
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Article: TRANSLATIONAL ONCOLOGY. 2018;11(6):1343-1349
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Article: CELL CHEMICAL BIOLOGY. 2018;25(10):1219-1230.e3
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Article: SCIENTIFIC REPORTS. 2018;8(1):12671
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Article: BLOOD. 2018;131(24):2670-2681
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Article: CELL DEATH & DISEASE. 2018;9(5):439
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Article: CELL DEATH & DISEASE. 2017;8(6):e2848
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Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):483-495
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Article: NATURE COMMUNICATIONS. 2017;8:14844
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Article: FRONTIERS IN ONCOLOGY. 2017;7:323
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Article: JOURNAL OF OVARIAN RESEARCH. 2016;9(1):27
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Article: CELL CYCLE. 2016;15(9):1267-1275
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Article: ONCOTARGET. 2016;7(2):1895-1911
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Article: GUT. 2015;64(10):1506-1516
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Article: CELL DEATH & DISEASE. 2015;6(6):e1794
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Article: ONCOGENE. 2014;33(35):4407-4417
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Article: PLOS ONE. 2014;9(11):e111125
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Article: GENES & DEVELOPMENT. 2014;28(1):58-70
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Article: CELL DEATH & DISEASE. 2013;4(10):e881
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2152-2156
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2157-2162
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Article: CELL CYCLE. 2012;11(24):4563-4569
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Article: CELL DEATH & DISEASE. 2012;3(4):e298
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Article: ONCOGENE. 2010;29(49):6442-6451
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Article: PLOS BIOLOGY. 2010;8(11):e1000521
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Article: CARCINOGENESIS. 2010;31(8):1475-1482
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Article: CARCINOGENESIS. 2010;31(6):1045-1053
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):85-89
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Article: ONCOGENE. 2010;29(9):1329-1338
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(37):15756-15761
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Article: LEUKEMIA & LYMPHOMA. 2009;50(9):1512-1518
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Article: CELL CYCLE. 2009;8(16):2509-2517
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Article: MOLECULAR CANCER. 2009;8:23
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Article: MOLECULAR CELL. 2009;33(4):462-471
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Article: ONCOGENE. 2008;27(35):4854-4859
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Article: CARCINOGENESIS. 2008;29(7):1428-1434
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Article: FEBS LETTERS. 2008;582(15):2173-2177
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Article: MOLECULAR ONCOLOGY. 2008;2(1):70-80
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Article: BRITISH JOURNAL OF HAEMATOLOGY. 2008;141(4):445-453
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Article: RADIOTHERAPY AND ONCOLOGY. 2008;86(3):407-411
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Article: CELLULAR ONCOLOGY. 2008;30(5):411-418
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(13):5401-5406
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Article: CELL DEATH AND DIFFERENTIATION. 2007;14(3):411-421
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Article: ONCOGENE. 2007;26(7):982-992
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Article: FEBS LETTERS. 2006;580(18):4401-4408
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Article: CELL DEATH AND DIFFERENTIATION. 2006;13(6):921-926
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Article: BRITISH JOURNAL OF HAEMATOLOGY. 2006;132(2):230-236
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(34):30384-30391
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Article: ONCOGENE. 2005;24(21):3484-3491
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Article: ONCOGENE. 2005;24(8):1320-1327
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Article: BRITISH JOURNAL OF HAEMATOLOGY. 2004;127(3):285-291
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Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;24(6):1559-1564
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(23):13303-13307
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Article: EUROPEAN JOURNAL OF CANCER. 2003;39(13):1828-1834
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Article: ONCOGENE. 2003;22(32):4993-5005
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Article: ANNALS OF MEDICINE. 2003;35(7):458-465
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Article: CARCINOGENESIS. 2002;23(12):2011-2018
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Article: SEMINARS IN CANCER BIOLOGY. 2002;12(5):381-387
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Article: INVESTIGATIONAL NEW DRUGS. 2002;20(3):253-259
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Article: FEBS LETTERS. 2002;524(1-3):69-72
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Article: CANCER LETTERS. 2002;180(2):211-221
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Article: NUCLEIC ACIDS RESEARCH. 2002;30(9):1991-1996
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Article: ONCOGENE. 2002;21(14):2119-2129
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Article: NATURE MEDICINE. 2002;8(3):282-288
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Article: ONCOGENE. 2001;20(39):5466-5474
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Article: ONCOGENE. 2001;20(17):2171-2177
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Article: BRAIN PATHOLOGY. 2001;11(2):159-168
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Article: APOPTOSIS. 2001;6(1-2):133-137
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Article: ONCOGENE. 2000;19(45):5123-5133
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Article: CANCER RESEARCH. 2000;60(18):5278-5283
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Article: EXPERIMENTAL CELL RESEARCH. 2000;256(2):400-410
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Article: GENE. 2000;246(1-2):247-254
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Article: MOLECULAR CANCER RESEARCH. 2000;11(1):31-39
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;265(1):1-6
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Article: ANTICANCER RESEARCH. 1999;19(4B):2939-2943
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Article: MOLECULAR AND CELLULAR BIOLOGY. 1999;19(5):3395-3402
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Article: ONCOGENE. 1998;17(18):2333-2337
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Article: BLOOD. 1998;91(5):1680-1687
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Article: SEMINARS IN CANCER BIOLOGY. 1998;8(5):369-378
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Article: ONCOGENE. 1997;15(22):2699-2704
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Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1997;11(1):97-104
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Article: NATURE MEDICINE. 1997;3(6):632-638
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Article: JOURNAL OF GENERAL VIROLOGY. 1997;78:893-903
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Article: MOLECULAR CANCER RESEARCH. 1997;8(2):121-131
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Article: MOLECULAR CANCER RESEARCH. 1996;7(12):1723-1732
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Article: NUCLEIC ACIDS RESEARCH. 1996;24(18):3560-3567
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Article: INTERNATIONAL JOURNAL OF CANCER. 1996;67(1):106-112
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Article: ONCOGENE. 1996;12(12):2731-2735
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Article: INTERNATIONAL JOURNAL OF CANCER. 1996;66(3):322-325
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Article: BLOOD. 1996;87(8):3360-3367
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Article: CURRENT OPINION IN CELL BIOLOGY. 1995;7(6):835-842
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Article: ONCOGENE. 1995;11(10):1963-1969
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Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;7(5):1123-1128
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Article: JOURNAL OF GENERAL VIROLOGY. 1995;76:2423-2432
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Article: CARCINOGENESIS. 1995;16(10):2515-2521
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Article: ONCOGENE. 1995;11(6):1027-1031
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Article: EUROPEAN JOURNAL OF CANCER PART B: ORAL ONCOLOGY. 1995;31B(5):328-332
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Article: MOLECULAR CANCER RESEARCH. 1995;6(9):1071-1075
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Article: INTERNATIONAL JOURNAL OF CANCER. 1995;61(5):683-691
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Article: NUCLEIC ACIDS RESEARCH. 1995;23(3):362-369
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Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;6(1):27-29
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Alla övriga publikationer
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Review: NATURE REVIEWS CLINICAL ONCOLOGY. 2024;21(2):106-120
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Corrigendum: ONCOGENE. 2023;42(9):709
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Corrigendum: CELL DEATH & DISEASE. 2022;13(8):672
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Corrigendum: CELL DEATH & DISEASE. 2019;10(10):769
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Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(4):330-341
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Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):418-421
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Review: FRONTIERS IN ONCOLOGY. 2016;6:21
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Review: CELL DEATH AND DIFFERENTIATION. 2015;22(8):1239-1249
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Review: FEBS LETTERS. 2014;588(16):2622-2627
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Editorial comment: CELL DEATH AND DIFFERENTIATION. 2013;20(11):1438-1439
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Editorial comment: CELL DEATH AND DIFFERENTIATION. 2012;19(1):180-183
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Review: CELL DEATH AND DIFFERENTIATION. 2011;18(9):1434-1440
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Review: ONCOGENE. 2010;29(30):4245-4252
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Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2010;88(7):645-652
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Editorial comment: LANCET ONCOLOGY. 2009;10(9):913-919
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Review: CANCER LETTERS. 2009;276(1):1-7
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Review: ONCOGENE. 2007;26(15):2243-2254
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Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2007;97:321-338
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Review: MEDICAL ONCOLOGY. 1998;15(4):222-228
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Review: EXPERIMENTAL CELL RESEARCH. 1997;237(1):14-18
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Review: LAKARTIDNINGEN. 1997;94(38):3268-3272
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Editorial comment: NATURE MEDICINE. 1997;3(8):839-840
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Other: GENE. 1995;162(2):231-234
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Other: ONCOGENE. 1995;10(9):1869-1874
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Review: MECHANISMS AND THERAPY OF LIVER CANCER. 1995;66:143-180
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Anställningar
- Professor, Onkologi-Patologi, Karolinska Institutet, 1999-
Examina och utbildning
- Docent, Tumörbiologi, Karolinska Institutet, 1987