Precisionsmedicin vid lungcancer – proteiner som nyckel till bättre behandling – Lukas Orres team

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Alla gruppmedlemmars publikationer

Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Table S1 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Figure S2 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Figure S6 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Table S2 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Figure S3 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Figure S5 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Data from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Figure S4 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Supplementary Figure Legends from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
Figure S1 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Journal article: MOLECULAR CANCER RESEARCH. 2025;23(9):807-821
IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α-Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
Journal article: JOURNAL OF PROTEOME RESEARCH. 2025;24(8):3913-3930
Quantitative Proteomic Analysis Reveals JMJD6 and DNAJB11 as Endogenous Substrates of E3 Ligase RFFL.
Narendradev ND; Marathe S; Baboo S; McClatchy DB; Diedrich JK; Jain P; Purwar R; Yates JR; Srinivasula SM
Preprint: BIORXIV. 2025
IL-17A potentiates malignant T-cell viability via electron transport chain complex I in cutaneous T-cell lymphoma
Attrish D; Dhamija B; Mukherjee D; Sawant V; Marathe S; Saul D; Basu M; Banik A; Sharma N; Shet T; Jain H; Kosinsky RL; Sharma P; Purwar R
Doctoral thesis: 2025
Harnessing proteomics for precision medicine in lung cancer
Berkovska O
Journal article: CANCER RESEARCH. 2025;85(5_Supplement):b026
Abstract B026: Leveraging patient-derived models to identify novel treatment options in high-grade serous ovarian cancer
Gudoityte G; Berkovska O; Orre L; Moussaud-Lemoderie E; Fernebro J; Joneborg U; Kallioniemi O; Seashore-Ludlow B
Article: ISCIENCE. 2025;28(2):111864
Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer
Pan Y; Berkovska O; Marathe S; Mermelekas G; Gudoityte G; Wolide AD; Arslan T; Seashore-Ludlow B; Lehtio J; Orre LM
Article: LEUKEMIA. 2024;38(11):2429-2442
The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia
Hagerstrand D; Oder B; Cortese D; Qu Y; Binzer-Panchal A; Osterholm C; Santos TDP; Rabbani L; Asl HF; Skaftason A; Ljungstrom V; Lundholm A; Koutroumani M; Haider Z; Jylha C; Mollstedt J; Mansouri L; Plevova K; Agathangelidis A; Scarfo L; Armand M; Muggen AF; Kay NE; Shanafelt T; Rossi D; Orre LM; Pospisilova S; Barylyuk K; Davi F; Vesterlund M; Langerak AW; Lehtio J; Ghia P; Stamatopoulos K; Sutton L-A; Rosenquist R
Article: CELL REPORTS MEDICINE. 2024;5(9):101699
Proteo-metabolomics and patient tumor slice experiments point to amino acid centrality for rewired mitochondria in fibrolamellar carcinoma
Long Jr D; Chan M; Han M; Kamdar Z; Ma RK; Tsai P-Y; Francisco AB; Barrow J; Shackelford DB; Yarchoan M; Mcbride MJ; Orre LM; Vacanti NM; Gujral TS; Sethupathy P
Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2024;7(3):809-822
Phage Display Identified Novel Leydig Cell Homing Peptides for Testicular Targeting
Jirwankar Y; Nair A; Marathe S; Dighe V
Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Struyf N; Osterroos A; Vesterlund M; Arnroth C; James T; Sunandar S; Mermelekas G; Bohlin A; Hamberg Levedahl K; Bengtzen S; Jafari R; Orre LM; Lehtio J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B; Erkers T
Article: JOURNAL OF IMMUNOLOGY. 2024;212(2):302-316
IL-17A Orchestrates Reactive Oxygen Species/HIF1a-Mediated Metabolic Reprogramming in Psoriasis
Dhamija B; Marathe S; Sawant V; Basu M; Attrish D; Mukherjee D; Kumar S; Pai MGJ; Wad S; Sawant A; Nayak C; V. Venkatesh K; Srivastava S; Barthel SR; Purwar R
Article: ONCOIMMUNOLOGY. 2023;12(1):2233402
Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8⁺ T cells towards the center of human lung tumors
Brownlie D; von Kries A; Valenzano G; Wild N; Yilmaz E; Safholm J; Al-Ameri M; Alici E; Ljunggren H-G; Schliemann I; Aricak O; de Flon FH; Michaelsson J; Marquardt N
Article: MOLECULAR CELL. 2023;83(20):3720-3739.e8
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress
Brunner A; Li Q; Fisicaro S; Kourtesakis A; Viiliainen J; Johansson HJ; Pandey V; Mayank AK; Lehtio J; Wohlschlegel JA; Spruck C; Rantala JK; Orre LM; Sangfelt O
Journal article: ANNALS OF ONCOLOGY. 2023;34:s1163-s1164
Proteomics-based phenotypic classification of non-smallcell lung cancer
Berkovska O; Mermelekas G; Orre L; Lehtio J
Preprint: RESEARCH SQUARE. 2023
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Erkers T; Struyf N; Arnroth C; Vesterlund M; James T; Sunandar S; Bohlin A; Hamberg-Levedahl K; Bengtzén S; Jafari R; Orre L; Lehtiö J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B
Article: DIAGNOSTIC CYTOPATHOLOGY. 2023;51(6):331-340
Digital droplet PCR TERT promoter mutational screening in fine needle aspiration cytology of thyroid lesions: A highly specific technique for pre-operative identification of high-risk cases
Hysek M; Hellgren LS; Stenman A; Darai-Ramqvist E; Ljung E; Schliemann I; Condello V; Larsson C; Zedenius J; Jatta K; Juhlin CC
Journal article: CANCER RESEARCH. 2023;83(7):6612
Data-driven hallmarks of cancer as a new paradigm for precision medicine: multi-omics and functional profiling in acute myeloid leukemia
Erkers T; Struyf N; James T; Marabita F; Vesterlund M; Vu N; Arnroth C; Osterroos A; Bohlin A; Bengtzen S; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
Article: NPJ PRECISION ONCOLOGY. 2023;7(1):32
Prediction model for drug response of acute myeloid leukemia patients
Trac QT; Pawitan Y; Mou T; Erkers T; Ostling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtio J; Lehmann S; Kallioniemi O; Vu TN
Conference publication: BLOOD. 2022;140:6299
Data-Driven Molecular Hallmarks of Acute Myeloid Leukemia: Biological, Prognostic and Therapeutic Implications
Erkers T; Marabita F; Struyf N; Vesterlund M; James T; Arnroth C; Bohlin A; Bengtzen S; Osterroos A; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(8):S11
062 High-throughput quantitative proteomics unveils HIF1α as a driver of IL17A-induced metabolic alterations favoring hyperproliferation in keratinocytes
Marathe SS; Mukherjee D; Basu M; Dhamija B; Sawant VV; Wad S; Attrish D; Kumar S; Purwar R
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(8):S22
127 IL-17 acts as the master regulator for metabolic rewiring in skin inflammation and drives keratinocytes towards a hyperproliferative phenotype
Dhamija B; Sawant VV; Basu M; Attrish D; Marathe SS; Purwar R
Article: NATURE PROTOCOLS. 2022;17(8):1832-1867
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry
Arslan T; Pan Y; Mermelekas G; Vesterlund M; Orre LM; Lehtio J
Article: LAB ON A CHIP. 2022;22(11):2192-2199
Semi-automated preparation of fine-needle aspiration samples for rapid on-site evaluation
Marques F; Hauser J; Iseri E; Schliemann I; van der Wijngaart W; Roxhed N
Preprint: RESEARCH SQUARE. 2021
Mass spectrometry-based proteomic analysis of NSCLC tumor and biopsy samples
Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
Preprint: RESEARCH SQUARE. 2021
STK11 pathway in vitro validation
Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Staaf J; Orre L
Preprint: RESEARCH SQUARE. 2021
Immune landscape evaluation of NSCLC clinical samples
Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
Preprint: RESEARCH SQUARE. 2021
Bioinformatics analysis of NSCLC multi-omics data
Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
Article: NATURE CANCER. 2021;2(11):1224-1242
Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms
Lehtio J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer HM; Mermelekas G; Pirmoradian M; Jonsson M; Brunnstrom H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevskaz M; Hansen CG; Haakensen VD; Helland A; Tamborero D; Johansson HJ; Branca RM; Planckz M; Staaf J; Orre LM
Article: PIGMENT CELL & MELANOMA RESEARCH. 2021;34(5):966-972
Presence and the roles of IL-9/Th9 axis in vitiligo
Kumar S; Marathe S; Dhamija B; Zambare U; Bilala R; Warang S; Nayak C; Purwar R
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(8):1932-1942
Multiomics Analysis and Systems Biology Integration Identifies the Roles of IL-9 in Keratinocyte Metabolic Reprogramming
Marathe S; Dhamija B; Kumar S; Jain N; Ghosh S; Dharikar JP; Srinivasan S; Das S; Sawant A; Desai S; Khan F; Syiemlieh A; Munde M; Nayak C; Gandhi M; Kumar A; Srivastava S; Venkatesh KV; Barthel SR; Purwar R
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2021;10(9):e12128
Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
Veerman RE; Teeuwen L; Czarnewski P; Gucluler Akpinar G; Sandberg A; Cao X; Pernemalm M; Orre LM; Gabrielsson S; Eldh M
Article: JOURNAL OF IMMUNOLOGY. 2021;206(11):2740-2752
IL-9 Abrogates the Metastatic Potential of Breast Cancer by Controlling Extracellular Matrix Remodeling and Cellular Contractility
Das S; Surve V; Marathe S; Wad S; Karulkar A; Srinivasan S; Dwivedi A; Barthel SR; Purwar R
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(5):580-588
The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
Mou T; Pawitan Y; Stahl M; Vesterlund M; Deng W; Jafari R; Bohlin A; Osterroos A; Siavelis L; Backvall H; Erkers T; Kiviluoto S; Seashore-Ludlow B; Ostling P; Orre LM; Kallioniemi O; Lehmann S; Lehtio J; Trung NV
Review: EXPERT REVIEW OF PROTEOMICS. 2020;17(11-12):797-812
A proteogenomic approach to target neoantigens in solid tumors
Verma A; Halder A; Marathe S; Purwar R; Srivastava S
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020;140(7):S117
889 Interleukin-9 promotes malignant T cell survival by inhibiting oxidative stress and lactic acidosis in cutaneous T cell lymphoma
Kumar S; Dhamija B; Marathe S; Karulkar A; Sharma N; Jain H; Purwar R
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):928-943
Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC
Tran YZ; Minozada R; Cao X; Johansson HJ; Branca RM; Seashore-Ludlow B; Orre LM
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):1047-1057
DEqMS: A Method for Accurate Variance Estimation in Differential Protein Expression Analysis
Zhu Y; Orre LM; Tran YZ; Mermelekas G; Johansson HJ; Malyutina A; Anders S; Lehtio J
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2020;318(4):L831-L843
Lung developmental arrest caused by PDGF-A deletion: consequences for the adult mouse lung
Gouveia L; Kraut S; Hadzic S; Vazquez-Liebanas E; Kojonazarov B; Wu C-Y; Veith C; He L; Mermekkas G; Schermuly RT; Weissmann N; Betsholtz C; Andrae J
Article: MOLECULAR CANCER RESEARCH. 2020;18(4):657-668
The Th9 Axis Reduces the Oxidative Stress and Promotes the Survival of Malignant T Cells in Cutaneous T-Cell Lymphoma Patients
Kumar S; Dhamija B; Marathe S; Ghosh S; Dwivedi A; Karulkar A; Sharma N; Sengar M; Sridhar E; Bonda A; Thorat J; Tembhare P; Shet T; Gujral S; Bagal B; Laskar S; Jain H; Purwar R
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: SCIENTIFIC REPORTS. 2020;10(1):3651
A microparticulate based formulation to protect therapeutic enzymes from proteolytic digestion: phenylalanine ammonia lyase as case study
de Sousa IP; Gourmel C; Berkovska O; Burger M; Leroux J-C
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(1):128-141
The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease
Haytural H; Mermelekas G; Emre C; Nigam SM; Carroll SL; Winblad B; Bogdanovic N; Barthet G; Granholm A-C; Orre LM; Tjernberg LO; Frykman S
Article: ONCOGENE. 2019;38(43):6881-6897
Proteomics identifies neddylation as a potential therapy target in small intestinal neuroendocrine tumors
Fotouhi O; Kjellin H; Juhlin CC; Pan Y; Vesterlund M; Ghaderi M; Yousef A; Andersson-Sand H; Kharaziha P; Caramuta S; Kjellman M; Zedenius J; Larsson C; Orre LM
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(8):S40
Breast cancer quantitative proteome and proteogenomic landscape
Johansson HJ; Socciarelli F; Vacanti NM; Haugen MH; Zhu Y; Siavelis I; Fernandez-Woodbridge A; Aure MR; Sennblad B; Vesterlund M; Branca RM; Orre LM; Huss M; Fredlund E; Beraki E; Garred O; Boeke J; Sauer T; Zhao W; Nord S; Hoglander EK; Jans DC; Brismar H; Haukaas TH; Bathen TF; Schlichting E; Naume B; Luders T; Borgen E; Kristensen VN; Russnes HG; Lingjaerde OC; Mills GB; Sahlberg KK; Borresen-Dale A-L; Lehtio J
Article: NATURE COMMUNICATIONS. 2019;10(1):1600
Breast cancer quantitative proteome and proteogenomic landscape
Johansson HJ; Socciarelli F; Vacanti NM; Haugen MH; Zhu Y; Siavelis I; Fernandez-Woodbridge A; Aure MR; Sennblad B; Vesterlund M; Branca RM; Orre LM; Huss M; Fredlund E; Beraki E; Garred O; Boekel J; Sauer T; Zhao W; Nord S; Hoglander EK; Jans DC; Brismar H; Haukaas TH; Bathen TF; Schlichting E; Naume B; Geisler J; Hofvind S; Engebraten O; Geitvik GA; Langerod A; Karesen R; Maelandsmo GM; Sorlie T; Skjerven HK; Park D; Hartman-Johnsen O-J; Luders T; Borgen E; Kristensen VN; Russnes HG; Lingjaerde OC; Mills GB; Sahlberg KK; Borresen-Dale A-L; Lehtio J
Article: MOLECULAR CELL. 2019;73(1):166-182.e7
SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization
Orre LM; Vesterlund M; Pan Y; Arslan T; Zhu Y; Woodbridge AF; Frings O; Fredlund E; Lehtio J
Article: NATURE BIOTECHNOLOGY. 2018;36(6):521-529
A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility
Wei B; Jolma A; Sahu B; Orre LM; Zhong F; Zhu F; Kivioja T; Sur I; Lehtio J; Taipale M; Taipale J
Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):1852
Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow (vol 9, 2018)
Zhu Y; Orre LM; Johansson HJ; Huss M; Boekel J; Vesterlund M; Fernandez-Woodbridge A; Branca RMM; Lehtio J
Article: NATURE COMMUNICATIONS. 2018;9(1):903
Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
Zhu Y; Orre LM; Johansson HJ; Huss M; Boekel J; Vesterlund M; Fernandez-Woodbridge A; Branca RMM; Lehtio J
Preprint: BIORXIV. 2017
Strong binding activity of few transcription factors is a major determinant of open chromatin
Wei B; Jolma A; Sahu B; Orre LM; Zhong F; Zhu F; Kivioja T; Sur IK; Lehtiö J; Taipale M; Taipale J
Article: BMC CANCER. 2017;17(1):650
Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells
Reithmeier A; Panizza E; Krumpel M; Orre LM; Branca RMM; Lehtio J; Ek-Rylander B; Andersson G
Article: SCIENTIFIC REPORTS. 2017;7(1):4513
Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome
Panizza E; Branca RMM; Oliviusson P; Orre LM; Lehtio J
Article: ONCOGENE. 2017;36(6):731-745
microRNAs with AAGUGC seed motif constitute an integral part of an oncogenic signaling network
Zhou Y; Frings O; Branca RM; Boekel J; le Sage C; Fredlund E; Agami R; Orre LM
Letter: LEUKEMIA & LYMPHOMA. 2016;57(11):2672-2676
The t(11;14)(q13;q32)/CCND1-IGH translocation is a recurrent secondary genetic aberration in relapsed chronic lymphocytic leukemia
Schliemann I; Oschlies I; Nagel I; Penas EMM; Siebert R; Sander B
Meeting abstract: CANCER RESEARCH. 2016;76:2385
Understanding the dynamic interplay between genetically different cancer cell clones in glioblastoma
Guo M; Heller S; Thorslund J; Orre L; Lehtio J; Nister M; Hagerstrand D
Conference publication: CANCER RESEARCH. 2016;76:3881
Breast cancer proteogenomics landscape defines subtype specific protein level regulations and reveals proteins coded by pseudogenic loci
Johansson H; Zhu Y; Haugland M; Sahlberg K; Fredlund E; Huss M; Vacanti N; Aure MR; Sennblad B; Kjellqvist S; Orre L; Lingjaerde OC; Borresen-Dale A-L; Lehtio J
Journal article: CANCER RESEARCH. 2016;76(14_Supplement):1109
Abstract 1109: AAGUGC-microRNAs are an integral part of an oncogenic signaling network driving non-small cell lung cancer proliferation
Zhou Y; Frings O; Fredlund E; Boekel J; Branca RM; Orre LM
Journal article: BIO-PROTOCOL. 2016;6(5)
Isolation of Genomic DNA from Mycobacterium Species
Kumar P; Marathe S; Bhaskar S
Article: EXPERIMENTAL CELL RESEARCH. 2015;336(1):158-170
Secretome protein signature of human gastrointestinal stromal tumor cells
Berglund E; Dare E; Branca RMM; Akcakaya P; Frobom R; Berggren P-O; Lui W-O; Larsson C; Zedenius J; Orre L; Lehtio J; Kim J; Branstrom R
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2015;97(3):511-520
Mycobacterium indicus pranii induces dendritic cell activation, survival, and Th1/Th17 polarization potential in a TLR-dependent manner
Kumar P; John V; Marathe S; Das G; Bhaskar S
Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(6):1552-1562
SpliceVista, a Tool for Splice Variant Identification and Visualization in Shotgun Proteomics Data
Zhu Y; Hultin-Rosenberg L; Forshed J; Branca RMM; Orre LM; Lehtio J
Article: NATURE METHODS. 2014;11(1):59-62
HiRIEF LC-MSMS enables deep proteome coverage and unbiased proteogenomics
Branca RMM; Orre LM; Johansson HJ; Granholm V; Huss M; Perez-Bercoff A; Forshed J; Kall L; Lehtio J
Article: ONCOGENE. 2013;32(49):5531-5540
S100A4 interacts with p53 in the nucleus and promotes p53 degradation
Orre LM; Panizza E; Kaminskyy VO; Vernet E; Graslund T; Zhivotovsky B; Lehtio J
Conference publication: CANCER RESEARCH. 2013;73(8):833
S100A4 interacts with p53 in the nucleus promoting its degradation.
Orre L; Panizza E; Kaminskyy V; Graslund T; Zhivotovsky B; Lehtio J
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S78
Cancer Proteomics - From low Resolution to High Resolution to Study Lung Cancer Phenotype
Lehtio J; De Petris L; Pernemalm M; Forshed J; Branca R; Orre LM
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2011;6(6):S304
MICRORNAS IN LUNG CANCER A FUNCTIONAL GENOMICS APPROACH FOR DISCOVERY AND VALIDATION OF NOVEL FACTORS DETERMINING RESPONSE TO TREATMENT WITH EGFR-INHIBITORS.
Orre LM; Le Sage C; Agami R; Lehtio J
Article: THYROID. 2010;20(10):1067-1076
Proteomic Study of Thyroid Tumors Reveals Frequent Up-Regulation of the Ca²⁺-Binding Protein S100A6 in Papillary Thyroid Carcinoma
Sofiadis A; Dinets A; Orre LM; Branca RM; Juhlin CC; Foukakis T; Wallin G; Hoog A; Hulchiy M; Zedenius J; Larsson C; Lehtio J
Article: PROTEOME SCIENCE. 2010;8:9
A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants
De Petris L; Pernemalm M; Elmberger G; Bergman P; Orre L; Lewensohn R; Lehtio J
Article: PROTEOME SCIENCE. 2009;7:43
A comparison between protein profiles of B cell subpopulations and mantle cell lymphoma cells
Stranneheim H; Orre LM; Lehtio J; Flygare J
Conference publication: CANCER RESEARCH. 2009;69
Proteomic studies in well differentiated thyroid tumors
Sofiadis A; Zedenius J; Wallin G; Foukakis T; Hoog A; Orre L; Lehtio J; Larsson C
Article: LUNG CANCER. 2009;63(3):410-417
Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer
De Petris L; Orre LM; Kanter L; Pernemalm M; Koyi H; Lewensohn R; Lehtio J
Article: PROTEOMICS. 2008;8(15):3008-3018
Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms
Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J
Article: JOURNAL OF PROTEOME RESEARCH. 2008;7(7):2712-2722
Evaluation of three principally different intact protein prefractionation methods for plasma biomarker discovery
Pernemalm M; Orre LM; Lengqvist J; Wikstrom P; Lewensohn R; Lehtio J
Doctoral thesis: 2008
Proteomic analysis of DNA damage induced stress signaling with focus on p53 : S100A6 regulation, function and potential as biomarker in lung cancer and as a novel therapeutic target
Orre L
Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3430-3431
FUNCTIONAL STUDIES OF S100A6 USING PROTEOMICS
Orre LM; Vernet E; Lengvist J; Graslund T; Lewensohn R; Lehtio J
Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3275-3276
QUANTITATIVE MEMBRANE PROTEOMICS APPLYING NARROW RANGE PEPTIDE ISOELECTRIC FOCUSING FOR STUDIES OF SMALL CELL LUNG CANCER RESISTANCE MECHANISMS
Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J
Article: MOLECULAR & CELLULAR PROTEOMICS. 2007;6(12):2122-2131
Up-regulation, modification, and translocation of S100A6 induced by exposure to ionizing radiation revealed by proteomics profiling
Orre LM; Pernemalm M; Lengqvist J; Lewensohn R; Lehtio J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;342(4):1211-1217
p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line
Orre LM; Stenerlöw B; Dhar S; Larsson R; Lewensohn R; Lehtiö J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;341(2):334-342
Rad51-related changes in global gene expression
Orre LM; Fält S; Szeles A; Lewensohn R; Wennborg A; Flygare J
Conference publication: BLOOD. 2005;106(11):666A
Detection of proteins related to therapeutic outcome, including drug resistance, in acute myeloid leukemia using mass spectrometry and gel based proteomic profiling.
Stenke L; Orre L; Dhar S; Larsson R; Lewensohn R; Lehtiö J
Journal article: BLOOD. 2005;106(11):2367
Detection of Proteins Related to Therapeutic Outcome, Including Drug Resistance, in Acute Myeloid Leukemia Using Mass Spectrometry and Gel Based Proteomic Profiling.
Stenke L; Orre L; Dhar S; Larsson R; Lewensohn R; Lehtiö J
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2004;3(10):S35
Detection of proteins related to doxorubicin resistance in myeloma and leukemia using mass Spectrometry-based proteomic profiling
Orre L; Dhar S; Lewensohn R; Stenke L; Larsson R; Lehtioe J
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Precisionsmedicin vid lungcancer – proteiner som nyckel till bättre behandling – Lukas Orres team

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