Precisionsmedicin vid lungcancer – proteiner som nyckel till bättre behandling – Lukas Orres team

Publikationer

Alla gruppmedlemmars publikationer

• Journal article: NPJ PRECISION ONCOLOGY. 2026;10(1):196

  Mass spectrometry-based proteomics delivers in-depth proteome profiling of FFPE lung cancer biopsies from single glass slides

  Berkovska O; Schliemann I; Mermelekas G; Ozkan NE; Nikpour M; Haakensen VD; Helland A; Lehtio J; Orre LM
• Review: NATURE PROTOCOLS. 2026;:1-26

  Differential protein expression analysis of quantitative mass spectrometry data using DEqMS

  Zhu Y; Berkovska O; Wang L; Yang M; Johansson HJ; Mermelekas G; Zarrineh M; Yin D; Orre LM; Lehtio J
• Article: NPJ PRECISION ONCOLOGY. 2026;10(1):117

  Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics

  Struyf N; Gezelius H; Lundmark A; Barizza C; Ploeger H; Rico Pizarro L; Vesterlund M; Mermelekas G; Osterroos A; Bohlin A; Bengtzen S; Hamberg Levedahl K; Jafari R; Orre LM; Lehtio J; Ostling P; Seashore-Ludlow B; Nordlund J; Lehmann S; Kallioniemi O; Erkers T
• Article: NPJ PRECISION ONCOLOGY. 2026;10(1):116

  Landscape of circular RNAs in acute myeloid leukemia and their clinical significance

  Nguyen T-H; Nguyen M-H; Nguyen H-N; Erkers T; Ostling P; Bohlin A; Osterroos A; Jafari R; Orre LM; Lehtio J; Lehmann S; Kallioniemi O; Pawitan Y; Vu TN
• Journal article: MOLECULAR CANCER RESEARCH. 2025;23(9):807-821

  IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α-Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Table S1 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Figure S2 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Figure S6 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Table S2 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Figure S3 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Figure S5 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Data from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Figure S4 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Supplementary Figure Legends from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025

  Figure S1 from IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma

  Mukherjee D; Marathe S; Attrish D; Sawant V; Dhamija B; Kumar S; Wad S; Basu M; Sharma N; Jain H; Barthel SR; Purwar R
• Journal article: JOURNAL OF PROTEOME RESEARCH. 2025;24(8):3913-3930

  Quantitative Proteomic Analysis Reveals JMJD6 and DNAJB11 as Endogenous Substrates of E3 Ligase RFFL

  Narendradev ND; Marathe S; Baboo S; McClatchy DB; Diedrich JK; Jain P; Purwar R; Yates III JR; Srinivasula SM
• Article: CANCERS. 2025;17(14):2363

  Ex Vivo Drug Sensitivity of Pleural Effusion-Derived Cells from Lung Cancer and Pleural Mesothelioma Patients Is Linked to Clinical Response

  Hutyra-Gram Otvos R; Krynska H; Gudoityte G; Skribek M; Oniscu A; Berkovska O; Strauss K; Zipprick J; Tamborero D; Alexeyenko A; Gad AKB; Seashore-Ludlow B; Dobra K
• Preprint: ELIFE. 2025

  Pathway activation model for personalized prediction of drug synergy

  Trac QT; Huang Y; Erkers T; Ostling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre L; Rantalainen M; Lehtio J; Lehmann S; Kallioniemi O; Pawitan Y; Vu TN
• Preprint: BIORXIV. 2025

  IL-17A potentiates malignant T-cell viability via electron transport chain complex I in cutaneous T-cell lymphoma

  Attrish D; Dhamija B; Mukherjee D; Sawant V; Marathe S; Saul D; Basu M; Banik A; Sharma N; Shet T; Jain H; Kosinsky RL; Sharma P; Purwar R
• Doctoral thesis: 2025

  Harnessing proteomics for precision medicine in lung cancer

  Berkovska O
• Visa fler

Medarbetare och kontakt

Gruppledare

• 

  Lukas Orre

  Senior Forskare | Docent

  E-postadress lukas.orre@ki.se

Alla medarbetare i gruppen

• 

  Olena Berkovska

  Anknuten till Forskning

  E-postadress olena.berkovska@ki.se
• George Christopher Field

  Doktorand

  E-postadress george.field@ki.se
• Soumitra Shrikrishna Marathe

  Postdoktor

  E-postadress soumitra.marathe@ki.se
• Georgios Mermelekas

  Senior Forskningsinfrastrukturspecialist

  E-postadress georgios.mermelekas@ki.se
• Igor Schliemann

  Doktorand

  E-postadress igor.schliemann@ki.se
• 

  Irene Villanueva Sanz

  Doktorand

  E-postadress irene.villanueva.sanz@ki.se
• Amare Wolide

  Postdoktor

  E-postadress amare.wolide@ki.se

Vår forskargrupp är en del av SciLifeLab

Foto: SciLifeLab

Vår forskargrupp är en del av SciLifeLab

SciLifeLab är ett nationellt samarbete mellan flera svenska lärosäten som samverkar med hälsovård, industri, myndigheter och internationella organisationer. Denna ledande nationella forskningsinfrastruktur och forskningsmiljö inom området molekylär biovetenskap tillhandahåller avancerade teknologier och expertis för grund- och tillämpad livsvetenskap.