Research group - Ujjwal Neogi

I completed my Ph.D. studies on translational genomics of HIV-1 subtypes circulating in India (HIV-1C_IN) at St. John’s Medical College, Rajiv Gandhi University of Health Sciences, India, in 2014. Post Ph.D. in 2015 I joined Prof. Maria Masucci’s group at Department of Cell and Molecular Biology, Karolinska Institutet as a postdoctoral researcher studying the role of herpesvirus encoded cysteine protease on evasion of host innate immune response. In 2019 I was appointed Assistant Professor at Neogi Group, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet. My research is aimed at understanding the mechanism of immune regulation during chronic viral infections. The focus of my research is on latent viruses like HIV-1 and herpesviruses and expand our understanding of the interplay between these viruses and host immune system using an integrative approach combining multi-omics with immunology, molecular, cell-biological and biochemical assays.

Joint Karolinska Institutet- Stellenbosch University Double Degree program.

I obtained my master degree in Medical Virology, Stellenbosch University, South Africa. My expertise is in virology and molecular biology. My Ph.D. program is to identify resistance mechanisms against protease inhibitors in South African HIV-1C patients’ high throughput system biology approach. I aim to integrate molecular biology, biochemistry, virology and structural biology to understand the resistance mechanisms.

I completed my master degree in Molecular Medicine from Tuebingen University, Germany (January 2018). In my master thesis, I focused on proteomics as well as cell biology and I will pursue these fields in a deeper way during my Ph.D. In particular, in my doctoral studies, I aim to perform immuno-proteomics research to map the intracellular pathways that are significantly modulated in HIV-1 immune control in Elite Controllers. I use high throughput techniques such as mass spectrometry, proximity extension assay, FACS, confocal microscopy, etc. My primary interests are death receptor signaling and stimulatory immune checkpoint molecules, and their roles in HIV-1 disease progression.

I got my Master’s Degree in Bioinformatics from Amrita School of Biotechnology, India in 2012 and had more than two years experience as Bioinformatics Programmer, at SciGenome Pvt Ltd. My doctoral studies aim at dealing with bioinformatics analysis of various kinds of "omics data" like transcriptome, proteome, microbiome and metabolome data related to HIV research. I am working to develop a simplified and efficient pipeline to integrate multi-omics data to draw a clinically relevant inference with reduced manual effort

I finished my master degree in immunology, Sun Yat-sen University, China (July 2018). During my master study, my research direction was towards finding an effective latency reversing agent (LRA) and cytotoxic T-lymphocytes’ (CTLs’) influence on the establishment and maintenance of HIV-1 latent reservoir. In my doctoral study, I aim to understand the role of mammalian target of rapamycin, also known as the mechanistic target of rapamycin (mTOR) pathway in HIV-1 latency and inflamm-aging in people living with HIV (PLHIV) using proteomics, metabolomics, and immunological studies. I am the recipient of China Govt China Scholarship Council (CSC) funding.

I have completed a double master’s degree in Genetics and Bioinformatics at Paris Diderot University in France. I joined Neogi Group as a Ph.D. student in August 2019. My Ph.D. project is about developing multi-omics pipelines in HIV-associated immune-aging.  I am working mostly on transcriptomics, proteomics, and metabolomics data obtained from cells and plasma from HIV-infected patients following antiretroviral therapy. My research aims to find biomarkers and pathways related to immune-aging in HIV context using single-cell, multi-omics, system biology, and machine learning approaches.

I submitted my Ph.D. at the Department of HIV/AIDS, National Institute for Research in Tuberculosis (affiliated to University of Madras, Chennai), India on understanding the transmitted/founder HIV-1 viruses in the establishment of the infection. Here, I have joined in Ujjwal Neogi’s group, LabMed as a Postdoctoral fellow to carry out the studies that involve in understanding the molecular mechanisms and the role of the HIV-1 latent reservoir in inflamm-aging in people living with HIV (PLHIV) who are on long-term successful therpay.

I obtained my Ph.D. degree from Institute of Pathophysiology and Allergy Research, Medical University of Vienna, in 2018. My Ph.D. research focused on the mechanism of entry and uncoating of ICAM-1 binding rhinoviruses. I am currently working as a postdoctoral fellow in the group of Dr. Ujjwal Neogi at Department of Laboratory Medicine, Karolinska Institute. My current project aims to understand the role of the sirtuin pathway in inflamm-aging of people living with HIV using integrative multi-omics and immunological assays.