Kamlendra Singh

Publications
Public outreach and news

Articles

Journal article: AIDS RESEARCH AND THERAPY. 2020;17(1):67
Increased HIV in Greater Kinshasa Urban Health Zones: Democratic Republic of Congo (2017-2018)
Pour M; James L; Singh K; Mampunza S; Baer F; Scott J; Berg MG; Rodgers MA; Cloherty GA; Hackett Jr J; McArthur CP
Article: AIDS. 2018;32(4):469-476
Ex-vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV type 1 non-B subtypes
Neogi U; Singh K; Aralaguppe SG; Rogers LC; Njenda DT; Sarafianos SG; Hejdeman B; Sonnerborg A
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2017;61(6):e00245-e00217
3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H.
Huber AD; Michailidis E; Tang J; Puray-Chavez MN; Boftsi M; Wolf JJ; Boschert KN; Sheridan MA; Leslie MD; Kirby KA; Singh K; Mitsuya H; Parniak MA; Wang Z; Sarafianos SG
Article: GENOME BIOLOGY AND EVOLUTION. 2017;9(5):1212-1228
Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.
de la Higuera I; Ferrer-Orta C; de Ávila AI; Perales C; Sierra M; Singh K; Sarafianos SG; Dehouck Y; Bastolla U; Verdaguer N; Domingo E
Article: SCIENTIFIC REPORTS. 2017;7:43908
Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity.
Kimani SG; Kumar S; Bansal N; Singh K; Kholodovych V; Comollo T; Peng Y; Kotenko SV; Sarafianos SG; Bertino JR; Welsh WJ; Birge RB
Article: JOURNAL OF MEDICAL VIROLOGY. 2017;89(1):106-111
Increased replication capacity following evolution of PYxE insertion in Gag-p6 is associated with enhanced virulence in HIV-1 subtype C from East Africa
Aralaguppe SG; Winner D; Singh K; Sarafianos SG; Quinones-Mateu ME; Soennerborg A; Neogi U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(33):9274-9279
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Salie ZL; Kirby KA; Michailidis E; Marchand B; Singh K; Rohan LC; Kodama EN; Mitsuya H; Parniak MA; Sarafianos SG
Article: THE LANCET HIV. 2016;3(4):e166-e174
Virological failure in patients with HIV-1 subtype C receiving antiretroviral therapy: an analysis of a prospective national cohort in Sweden
Haggblom A; Svedhem V; Singh K; Sonnerborg A; Neogi U
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2016;71(2):367-371
Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries
Neogi U; Haggblom A; Singh K; Rogers LC; Rao SD; Amogne W; Schuelter E; Zazzi M; Arnold E; Sarafianos SG; Sonnerborg A
Article: HEPATOLOGY. 2015;62(4):1024-1036
4'-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.
Takamatsu Y; Tanaka Y; Kohgo S; Murakami S; Singh K; Das D; Venzon DJ; Amano M; Higashi-Kuwata N; Aoki M; Delino NS; Hayashi S; Takahashi S; Sukenaga Y; Haraguchi K; Sarafianos SG; Maeda K; Mitsuya H
Article: JOURNAL OF VIROLOGY. 2015;89(13):6848-6859
Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
Ferrer-Orta C; de la Higuera I; Caridi F; Sánchez-Aparicio MT; Moreno E; Perales C; Singh K; Sarafianos SG; Sobrino F; Domingo E; Verdaguer N
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2015;96(1):121-135
CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease.
Strauss KA; Jinks RN; Puffenberger EG; Venkatesh S; Singh K; Cheng I; Mikita N; Thilagavathi J; Lee J; Sarafianos S; Benkert A; Koehler A; Zhu A; Trovillion V; McGlincy M; Morlet T; Deardorff M; Innes AM; Prasad C; Chudley AE; Lee INW; Suzuki CK
Article: THE FASEB JOURNAL. 2015;29(1):70-80
Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.
Kirby KA; Ong YT; Hachiya A; Laughlin TG; Chiang LA; Pan Y; Moran JL; Marchand B; Singh K; Gallazzi F; Quinn TP; Yoshimura K; Murakami T; Matsushita S; Sarafianos SG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(35):24533-24548
4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms.
Michailidis E; Huber AD; Ryan EM; Ong YT; Leslie MD; Matzek KB; Singh K; Marchand B; Hagedorn AN; Kirby KA; Rohan LC; Kodama EN; Mitsuya H; Parniak MA; Sarafianos SG
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2014;58(8):4894-4898
Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
Adedeji AO; Singh K; Kassim A; Coleman CM; Elliott R; Weiss SR; Frieman MB; Sarafianos SG
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2013;57(12):6254-6264
Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
Kirby KA; Michailidis E; Fetterly TL; Steinbach MA; Singh K; Marchand B; Leslie MD; Hagedorn AN; Kodama EN; Marquez VE; Hughes SH; Mitsuya H; Parniak MA; Sarafianos SG
Article: JOURNAL OF VIROLOGY. 2013;87(14):8017-8028
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms.
Adedeji AO; Severson W; Jonsson C; Singh K; Weiss SR; Sarafianos SG
Article: RETROVIROLOGY. 2013;10:65
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.
Michailidis E; Ryan EM; Hachiya A; Kirby KA; Marchand B; Leslie MD; Huber AD; Ong YT; Jackson JC; Singh K; Kodama EN; Mitsuya H; Parniak MA; Sarafianos SG
Article: ANTIVIRAL RESEARCH. 2013;98(3):380-385
Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.
Rai DK; Schafer EA; Singh K; McIntosh MA; Sarafianos SG; Rieder E
Article: CELLULAR AND MOLECULAR BIOLOGY. 2012;58(1):187-195
Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant.
Michailidis E; Singh K; Ryan EM; Hachiya A; Ong YT; Kirby KA; Marchand B; Kodama EN; Mitsuya H; Parniak MA; Sarafianos SG
Article: CELLULAR AND MOLECULAR BIOLOGY. 2012;58(1):71-79
Preparation of biologically active single-chain variable antibody fragments that target the HIV-1 gp120 V3 loop.
Ong YT; Kirby KA; Hachiya A; Chiang LA; Marchand B; Yoshimura K; Murakami T; Singh K; Matsushita S; Sarafianos SG
Article: CELLULAR AND MOLECULAR BIOLOGY. 2012;58(1):115-121
STRUCTURAL AND BIOCHEMICAL BASIS FOR THE DIFFERENCE IN THE HELICASE ACTIVITY OF TWO DIFFERENT CONSTRUCTS OF SARS-COV HELICASE
Adedeji AO; Singh K; Sarafianos SG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(45):38110-38123
Biochemical mechanism of HIV-1 resistance to rilpivirine.
Singh K; Marchand B; Rai DK; Sharma B; Michailidis E; Ryan EM; Matzek KB; Leslie MD; Hagedorn AN; Li Z; Norden PR; Hachiya A; Parniak MA; Xu H-T; Wainberg MA; Sarafianos SG
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2012;56(9):4718-4728
Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase.
Adedeji AO; Singh K; Calcaterra NE; DeDiego ML; Enjuanes L; Weiss S; Sarafianos SG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(35):29988-29999
HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors.
Hachiya A; Marchand B; Kirby KA; Michailidis E; Tu X; Palczewski K; Ong YT; Li Z; Griffin DT; Schuckmann MM; Tanuma J; Oka S; Singh K; Kodama EN; Sarafianos SG
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2012;56(4):2048-2061
Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.
Kirby KA; Marchand B; Ong YT; Ndongwe TP; Hachiya A; Michailidis E; Leslie MD; Sietsema DV; Fetterly TL; Dorst CA; Singh K; Wang Z; Parniak MA; Sarafianos SG
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2012;56(3):1630-1634
Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.
Sohl CD; Singh K; Kasiviswanathan R; Copeland WC; Mitsuya H; Sarafianos SG; Anderson KS
Article: NUCLEIC ACIDS RESEARCH (NAR). 2012;40(1):345-359
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Ndongwe TP; Adedeji AO; Michailidis E; Ong YT; Hachiya A; Marchand B; Ryan EM; Rai DK; Kirby KA; Whatley AS; Burke DH; Johnson M; Ding S; Zheng Y-M; Liu S-L; Kodama E-I; Delviks-Frankenberry KA; Pathak VK; Mitsuya H; Parniak MA; Singh K; Sarafianos SG
Article: PLOS ONE. 2012;7(5):e36521
Mechanism of nucleic acid unwinding by SARS-CoV helicase.
Adedeji AO; Marchand B; Te Velthuis AJW; Snijder EJ; Weiss S; Eoff RL; Singh K; Sarafianos SG
Article: INT J CURR CHEM. 2011;2(4):253-260
Hepatitis B Virus genotypic differences map structurally close to NRTI resistance hot spots.
Michailidis E; Singh K; Kirby KA; Hachiya A; Yoo W; Hong SP; Kim S-O; Folk WR; Sarafianos SG
Article: CELLULAR AND MOLECULAR BIOLOGY. 2011;57(1):40-46
The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase.
Kirby KA; Singh K; Michailidis E; Marchand B; Kodama EN; Ashida N; Mitsuya H; Parniak MA; Sarafianos SG
Article: PLOS ONE. 2011;6(1):e16242
K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism.
Hachiya A; Kodama EN; Schuckmann MM; Kirby KA; Michailidis E; Sakagami Y; Oka S; Singh K; Sarafianos SG
Article: PLOS ONE. 2010;5(12):e15049
Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.
Durk RC; Singh K; Cornelison CA; Rai DK; Matzek KB; Leslie MD; Schafer E; Marchand B; Adedeji A; Michailidis E; Dorst CA; Moran J; Pautler C; Rodriguez LL; McIntosh MA; Rieder E; Sarafianos SG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(49):38700-38709
The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.
Schuckmann MM; Marchand B; Hachiya A; Kodama EN; Kirby KA; Singh K; Sarafianos SG
Article: JOURNAL OF VIROLOGY. 2010;84(19):9817-9830
Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors.
Tebit DM; Lobritz M; Lalonde M; Immonen T; Singh K; Sarafianos S; Herchenröder O; Kräusslich H-G; Arts EJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(51):35681-35691
Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.
Michailidis E; Marchand B; Kodama EN; Singh K; Matsuoka M; Kirby KA; Ryan EM; Sawani AM; Nagy E; Ashida N; Mitsuya H; Parniak MA; Sarafianos SG
Article: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2009;84(1):105-117
A new DNA polymerase I from Geobacillus caldoxylosilyticus TK4: cloning, characterization, and mutational analysis of two aromatic residues.
Sandalli C; Singh K; Modak MJ; Ketkar A; Canakci S; Demir I; Belduz AO
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Review: BIOLOGY. 2018;7(1):E5-5
Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions
Shanbhag V; Sachdev S; Flores JA; Modak MJ; Singh K
Review: VIRUSES. 2014;6(9):3535-3562
Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
Singh K; Flores JA; Kirby KA; Neogi U; Sonnerborg A; Hachiya A; Das K; Arnold E; McArthur C; Parniak M; Sarafianos SG
Review: VIRUSES. 2010;2(2):606-638
Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.
Singh K; Marchand B; Kirby KA; Michailidis E; Sarafianos SG

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