Soham Gupta

Soham Gupta

Assistant Senior Lecturer
Telephone: +46852483751
Visiting address: Alfred Nobels alle 8, 14183 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Klin Mikrobiologi Ujjwal Neogi, 141 52 Huddinge

About me

  • The focus of my research is to expand our understanding of the interplay
    between viruses and host immune system using an integrative approach.
    I completed my Ph.D. studies on translational genomics of HIV-1 subtypes
    circulating in India (HIV-1CIN) at St. John’s Medical College, Rajiv Gandhi
    University of Health Sciences, India, in 2014. Post Ph.D. in 2015 I joined
    Prof. Maria Masucci’s group at Department of Cell and Molecular Biology,
    Karolinska Institutet as a postdoctoral researcher studying the role of
    herpesvirus encoded cysteine protease on evasion of host innate immune
    response. In 2019 I was appointed Assistant Professor at Division of
    Clinical Microbiology, Department of Laboratory Medicine, Karolinska
    Institutet.

Research

  • My research is aimed at understanding the mechanism of immune regulation
    during viral infections. The focus of my research is on emerging and
    re-emerging viruses like Coronaviruses, Zika virus, CCHFV etc. and latent
    viruses like herpesviruses and HIV-1 and expand our understanding of the
    interplay between these viruses and host immune system using an integrative
    approach combining multi-omics with immunology, molecular, cell-biological
    and biochemical assays.

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2022 - 31 December 2025
    In spite of significant advances in virology, emerging and re-emerging respiratory viral infections caused by human pathogenic coronaviruses and Influenza virus remain a major threat to human health. At present there is no specific antiviral agents or vaccine against most of these viruses. While each of these viruses are structurally different they often share similar host innate response. In severe form, these viruses cause acute respiratory distress that is characterized by a dysregulated immune response and metabolic alterations and the link between these two biological processes are still not well characterized. Interferon stimulatory gene 15 (ISG15) can bind to several proteins of interferon (IFN) signaling and metabolic pathways and alter their functions. Using advanced multi-omics and cell culture systems will test the hypothesis that ISG15 induced during viral infections integrates a diverse array of signals that control innate immune response and cell metabolism. To test this, we will i) identify and integrate the immunological and metabolic changes during virus infection, ii) investigate the role of ISGylation in regulation of these pathways and finally iii) create ex vivo and in vivo models to explore the regulatory mechanisms in a more physiological condition. The study will provide new possibilities for therapeutic modulation of immune-metabolic responses against RNA viruses that are responsible for most of the fatal epidemics and pandemics.

Employments

  • Assistant Senior Lecturer, Department of Laboratory Medicine, Karolinska Institutet, 2025-
  • Assistant Professor, Department of Laboratory Medicine, Karolinska Institutet, 2019-2025

News from KI

Events from KI