The Systems Virology Lab – Ujjwal Neogi

The Systems Virology lab at Laboratory Medicine focuses on using systems biology and experimental approaches to understand the biology of host-pathogen interactions targeted towards the RNA viruses. The group aims to identify the components of the immune response that are required for natural immune protection and disease severity that can be translated into the future development of vaccine and antiviral strategies against emerging and re-emerging viruses.

Part of the Department of Laboratory Medicine
Team Innate immune responses during viral infections
Illustration av scheme graph of the type I interferon signaling pathways.

Team Innate immune responses during viral infections

We aim to understand common global interferon-stimulated gene (ISG) responses against different viruses can provide a novel avenue for viral antagonism.


Lead: Soham Gupta.

Connection between metabolism and fatigue after Crimean-Congo Fever
Hyalomma tick

Connection between metabolism and fatigue after Crimean-Congo Fever

A recent study published by researchers from Karolinska Institutet in collaboration with Sivas Cumhuriyet University, Turkey, sheds light on the connection between Crimean-Congo Haemorrhagic Fever Virus (CCHFV) infection and prolonged fatigue.

New insights into the cellular response to SARS-CoV-2 infection
Photo of Ujjwal Neogi, Department of Laboratory Medicine

New insights into the cellular response to SARS-CoV-2 infection

The COVID-19 pandemic caused by the new coronavirus has created an unprecedented public health challenge globally. Little was known about how the infecting cells respond to the virus and how the virus hijacks the host cellular machinery. A study led by researchers at Karolinska Institutet published in Emerging Microbes & Infection gives new insights into the virus-host interplay enabling newer ideas to tackle the virus.

New biomarker for severe COVID-19
The image shows illustrated and colourful coronavirus with a microscope in the background.

New biomarker for severe COVID-19

During the pandemic, it has become evident that people with cardiovascular disease and obesity are at much higher risk of developing very severe, even fatal COVID-19 disease. Researchers at Karolinska Institutet have identified some metabolic processes that SARS-CoV-2 uses to attack lung tissue. 

Publications

Selected publications

Funding

Funders

Members and contact

Group leader

All members of the group

Collaborators

Prof. Susanne Dam Nielsen, University of Copenhagen, Rigshospitalet, Denmark (Aging and HIV)

Prof. Ali Mirazimi, Karolinska Institutet, Sweden (Emerging Diseases)

Prof. Joao Pedro De Magalhaes, University of Liverpool, UK (Aging)

Prof. Liam O’Mahony, APC Microbiome, Ireland (Microbiome)

Prof. Nazif Elaldi, Cumhuriyet University, Sivas, Turkey (CCHF)

Prof. Siddappa Byrareddy, Nebraska Medical Center, Omaha, NE (Primate model)

Prof. Akhil C. Banerjea, Advanced Institute of Virology, India (Emerging Diseases)

Prof. Aman Russom, KTH Royal Institute of Technology, Sweden (Bioengineering)

Prof. Ulf Landgren, Uppsala University, Sweden (Advanced molecular techniques)

Docent Erin Gabriel, Karolinska Institutet, Sweden (Statistical mathematics)

Docent Akos Vegvary, Karolinska Institutet, Sweden (Proteomics)

Keywords:
Clinical Laboratory Medicine Medical Biotechnology (focus on Cell Biology (incl. Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Microbiology in the medical area
UN
Content reviewer:
Ujjwal Neogi
Christina Sundqvist
22-03-2024