Cellplasticitet och behandlingsresistens vid neuroblastom och paragangliom – Schlisio Lab

Publikationer

Utvalda publikationer

• Article: NPJ PRECISION ONCOLOGY. 2025;9(1):324

  Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas

  Bullova P; Cui P; Arceo M; Zhu J; Li W; Plescher M; Poltorachenko V; Stripling K; Santangeli C; Mykhaylechko L; Kastriti ME; Larsson C; Juhlin CC; Mints M; Schlisio S
• Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167373

  Oxygen-sensitive Regulation of Mitochondrial Mass and its implication in the von Hippel-Lindau Syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Juhlin CC; von Kriegsheim A; Cao Y; Schlisio S
• Article: NATURE METABOLISM. 2022;4(6):739-758

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Article: NATURE COMMUNICATIONS. 2021;12(1):5309

  Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

  Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
• Article: NUCLEIC ACIDS RESEARCH. 2021;49(5):2509-2521

  Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors

  Shi Y; Yuan J; Rraklli V; Maxymovitz E; Cipullo M; Liu M; Li S; Westerlund I; Bedoya-Reina OC; Bullova P; Rorbach J; Juhlin CC; Stenman A; Larsson C; Kogner P; O'Sullivan MJ; Schlisio S; Holmberg J
• Letter: CANCER CELL. 2021;39(2):134-135

  Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

  Bedoya-Reina OC; Schlisio S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006

  EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

  Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nister M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WGJ; Schlisio S
• Article: CELL REPORTS. 2018;24(5):1316-1329

  PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

  Rodriguez J; Herrero A; Li S; Rauch N; Quintanilla A; Wynne K; Krstic A; Acosta JC; Taylor C; Schlisio S; von Kriegsheim A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6137-E6146

  Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression

  Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Surova O; Sodersten E; Kogner P; Nyman U; Schlisio S; Holmberg J
• Article: GENES & DEVELOPMENT. 2017;31(10):1036-1053

  Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA

  Fell SM; Li S; Wallis K; Kock A; Surova O; Rraklli V; Hoefig CS; Li W; Mittag J; Henriksson MA; Kenchappa RS; Holmberg J; Kogner P; Schlisio S
• Article: ONCOTARGET. 2016;7(23):34229-34239

  XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis

  Choo Z; Koh RYL; Wallis K; Koh TJW; Kuick CH; Sobrado V; Kenchappa RS; Loh AHP; Soh SY; Schlisio S; Chang KTE; Chen ZX
• Article: DEVELOPMENTAL CELL. 2016;36(2):164-178

  The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis

  Li S; Fell SM; Surova O; Smedler E; Wallis K; Chen ZX; Hellman U; Johnsen JI; Martinsson T; Kenchappa RS; Uhlen P; Kogner P; Schlisio S
• Article: HYPOXIA (AUCKL). 2016;4:15-27

  The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

  Koivunen P; Fell SM; Lu W; Rabinowitz JD; Kung AL; Schlisio S
• Article: CANCER DISCOVERY. 2014;4(4):434-451

  RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma

  Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Hellman U; Sandberg R; Kenchappa RS; Martinson T; Johnsen JI; Kogner P; Schlisio S
• Article: ENDOCRINE-RELATED CANCER. 2010;18(1):73-83

  Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

  Astuti D; Ricketts CJ; Chowdhury R; McDonough MA; Gentle D; Kirby G; Schlisio S; Kenchappa RS; Carter BD; Kaelin WGJ; Ratcliffe PJ; Schofield CJ; Latif F; Maher ER
• Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(10):4104-4112

  Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum

  Schlisio S
• Article: GENES & DEVELOPMENT. 2008;22(7):884-893

  The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

  Schlisio S; Kenchappa RS; Vredeveld LCW; George RE; Stewart R; Greulich H; Shahriari K; Nguyen NV; Pigny P; Dahia PL; Pomeroy SL; Maris JM; Look AT; Meyerson M; Peeper DS; Carter BD; Kaelin WGJ
• Article: NATURE CELL BIOLOGY. 2008;10(3):361-369

  VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

  Young AP; Schlisio S; Minamishima YA; Zhang Q; Li L; Grisanzio C; Signoretti S; Kaelin WGJ
• Article: MOLECULAR CELL. 2007;28(1):15-27

  pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-κB agonist Card9 by CK2

  Yang H; Minamishima YA; Yan Q; Schlisio S; Ebert BL; Zhang X; Zhang L; Kim WY; Olumi AF; Kaelin WGJ
• Article: CANCER CELL. 2005;8(2):155-167

  Neuronal apoptosis linked to EgIN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer

  Lee S; Nakamura E; Yang HF; Wei WY; Linggi MS; Sajan MP; Farese RV; Freeman RS; Carter BD; Kaelin WGJ; Schlisio S

Alla gruppmedlemmars publikationer

• Article: CELL REPORTS MEDICINE. 2026;7(4):102715

  Single-cell analysis highlights the significance of malignant cell IFN/MHC-II for immunotherapy response in head and neck squamous cell carcinoma

  Mints M; Sample RA; Parikh AS; Zaretsky JM; Qi Z; Law T; Wang F; Barrett TF; Mullins R; Reeb A; Greenwald AC; Stoller E; Ramadan S; Gerndt S; Oppelt P; Ley J; Thorstad W; Paniello RC; Rich JT; Harbison RA; Zolkind PA; Jackson RS; Pipkorn P; Adkins DR; Uppaluri R; Tirosh I; V. Puram S
• Journal article: MOLECULAR CANCER RESEARCH. 2026

  Comparative ASCL1 interactome analysis reveals CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified neuroblastoma.

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Article: NATURE COMMUNICATIONS. 2026;17(1):2326

  Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage

  Poverennaya I; Murtazina A; Li L; Maili L; Sourada L; Montano-Gutierrez LF; Galimullina R; Steinschaden T; Kaiser M; Zikmund T; Goralija A; Gao T; Attina A; Clara O; Bartenhagen C; Erickson A; Gershtein Y; Chen S; Polaskova K; Sterba J; Semasch B; Anderson ER; Prakash V; Vincent T; Arceo M; Kogner P; Schlisio S; Kharchenko PV; David A; Kaiser J; Fischer M; Skoda J; Trainor PA; Chagin AS; Adameyko I
• Article: CELL DEATH & DISEASE. 2025;17(1):85

  Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors

  Strandgren C; Rondahl V; Oppelt A-S; Ohlin S; Heldin A; Wiman KG
• Article: NPJ PRECISION ONCOLOGY. 2025;9(1):378

  Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association.

  Wizel A; Spence MDA; Mints M; Britton W; Okolo O; Yu V; Cioffi I; Caruana S; Troob SH; Faquin WC; Lin DT; Tirosh I; Puram SV; Parikh AS; Drier Y
• Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2025;23(1):1304

  Spatial profiling of HPV-stratified head and neck squamous cell carcinoma reveals distinct immune niches and microenvironmental architectures.

  Markovits E; Klymyshyn D; Froumine R; Zong H; Mints M; Mahadevan S; Bloom K; Bates J; Thomas GJ; Diehl L; Puig O; Aggarwal A
• Preprint: BIORXIV. 2025

  Comparative ASCL1 interactome analysis reveals CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified neuroblastoma

  Mykhaylechko L; Woods LM; Papachristou EK; Gomez RL; Ramachandran R; Lundie-Brown J; Marcos D; Drummond R; Ali FR; Carroll J; Philpott A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2025;122(43):e2516922122

  HIF2α negatively regulates MYCN protein levels and promotes a low- risk noradrenergic phenotype in neuroblastoma

  Yuan J; Maitra S; Antoniou E; Zhu J; Li W; Demirel IS; Toskas K; Martinez IL; Ozcimen L; Lindehell H; Muhr J; Stenman J; Kogner P; Bedoya-Reina OC; Schlisio S; Holmberg J
• Article: PLOS BIOLOGY. 2025;23(10):e3003414

  Recurrent circuits encode de novo visual center-surround computations in the mouse superior colliculus

  Cui P; Song K; Mariatos-Metaxas D; Isla AG; Femenia T; Lazaridis I; Meletis K; Kumar A; Kardamakis AA
• Article: NPJ PRECISION ONCOLOGY. 2025;9(1):324

  Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas

  Bullova P; Cui P; Arceo M; Zhu J; Li W; Plescher M; Poltorachenko V; Stripling K; Santangeli C; Mykhaylechko L; Kastriti ME; Larsson C; Juhlin CC; Mints M; Schlisio S
• Preprint: BIORXIV. 2025

  DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells

  Mantica G; Vedi A; Tuval A; Huerga Encabo H; Hayler D; Krzywon A; Mitchell E; Dunn W; Biezuner T; Bastos H; Sham K; Santoro A; Lee J; Williams N; Danin A; Chapal N; Moskovitz Y; Arruda A; Fiorillo E; Orru V; Marongiu M; McKinney E; Cucca F; Collin M; Minden M; Campbell P; Vassiliou G; Fabre M; Nangalia J; Bonnet D; Shlush L; Laurenti E
• Article: DEVELOPMENTAL CELL. 2025;60(17):2248-2263.e11

  Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity

  Xu Y; Lou D; Chen P; Li G; Usoskin D; Pan J; Li F; Huang S; Hess C; Tang R; Hu X; Yu J; Arceo M; de Krijger RR; Tischler AS; Schlisio S; Ernfors P; Hu Y; Wang J
• Journal article: MILITARY MEDICAL RESEARCH. 2025;12(1):46

  Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

  Jia Z-X; Guo M-T; Li M-M; Liao P; Yan B; Zhang W; Cheng F-Y; Liu Y-R; Zhang Z-H; Wei C; Zhou J; Chen F-L; Lei P; Ge X-T
• Article: STEM CELLS. 2025;43(8):sxaf026

  DNA hydroxy methylases Tet1 and Tet2 regulate bone aging and bone marrow stromal cell metabolism through the IGF-1/mTOR signaling axis

  Smith N; Cakouros D; Ryan FJ; Lynn DJ; Paton S; Arthur A; Gronthos S
• Preprint: RESEARCH SQUARE. 2025

  Postnatal Sustentacular Cells as Chromaffin Progenitors and Tumor Cells of Origin in VHL-Related Paragangliomas

  Bullova P; Cui P; Arceo M; Zhu J; Li W; Plescher M; Poltorachenko V; Stripling K; Santangeli C; Kastriti ME; Larsson C; Juhlin CC; Mints M; Schlisio S
• Article: NATURE CANCER. 2025;6(6):1088-1101

  The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution

  Tyler M; Gavish A; Barbolin C; Tschernichovsky R; Hoefflin R; Mints M; Puram SV; Tirosh I
• Review: AMERICAN SOCIETY OF CLINICAL ONCOLOGY EDUCATIONAL BOOK / ASCO. AMERICAN SOCIETY OF CLINICAL ONCOLOGY. MEETING. 2025;45(3):e473616

  Capturing Unicorns: Targeting Cancers With TP53 Mutations, RAS Alterations Beyond G12C, and MTAP Loss-No Target Is Out of the Realm of Possibility.

  Shah PA; Wiman KG; Cichowski K; Rodon Ahnert J
• Article: PLOS PATHOGENS. 2025;21(5):e1013112

  A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion

  Yu M; Lin A; Baharom F; Li S; Legendre M; Coves-Datson E; Sohlberg E; Schlisio S; Lore K; Markovitz DM; Smed-Soerensen A
• Preprint: BIORXIV. 2025

  Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors

  Strandgren C; Rondahl V; Oppelt A-S; Öhlin S; Heldin A; Wiman KG
• Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167373

  Oxygen-sensitive Regulation of Mitochondrial Mass and its implication in the von Hippel-Lindau Syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Juhlin CC; von Kriegsheim A; Cao Y; Schlisio S
• Preprint: BIORXIV. 2024

  HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma

  Yuan J; Maitra S; Antoniou E; Zhu J; Li W; Demirel IS; Toskas K; Martinez IL; Ozcimen L; Lindehell H; Kogner P; Bedoya-Reina O; Schlisio S; Holmberg J
• Article: CELL REPORTS. 2024;43(10):114784

  Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery

  Ramos AD; Liang YY; Surova O; Bacanu S; Gerault M-A; Mandal T; Ceder S; Langeback A; Osterroos A; Ward GA; Bergh J; Wiman KG; Lehmann S; Prabhu N; Loof S; Nordlund P
• Article: CELLULAR & MOLECULAR BIOLOGY LETTERS. 2024;29(1):127

  A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ

  Wei C; Peng D; Jing B; Wang B; Li Z; Yu R; Zhang S; Cai J; Zhang Z; Zhang J; Han L
• Article: CELL DEATH & DISEASE. 2024;15(8):616

  A novel protein encoded by circCOPA inhibits the malignant phenotype of glioblastoma cells and increases their sensitivity to temozolomide by disrupting the NONO-SFPQ complex

  Peng D; Wei C; Jing B; Yu R; Zhang Z; Han L
• Preprint: BIORXIV. 2024;BIORXIV

  A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion.

  Yu M; Lin A; Baharom F; Li S; Legendre M; Covés-Datson E; Sohlberg E; Schlisio S; Loré K; Markovitz DM; Smed-Sörensen A
• Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2024;129:e10719

  Therapeutic targeting of TP53 nonsense mutations in cancer

  Strandgren C; Wiman KG
• Article: FRONTIERS IN PHARMACOLOGY. 2024;15:1375112

  ecGBMsub: an integrative stacking ensemble model framework based on eccDNA molecular profiling for improving IDH wild-type glioblastoma molecular subtype classification

  Li Z; Wei C; Zhang Z; Han L
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(7):4107

  The Catalytic Activity of Human REV1 on Undamaged and Damaged DNA.

  Stolyarenko AD; Novikova AA; Shilkin ES; Poltorachenko VA; Makarova AV
• Journal article: CANCER LETTERS. 2024;585:216665

  Polo-like kinase 4 promotes tumorigenesis and glucose metabolism in glioma by activating AKT1 signaling

  Wang B; Zhang X; Li Z-S; Wei C; Yu R-Z; Du X-Z; He Y-J; Ren Y; Zhen Y-W; Han L
• Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(3):167041

  TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation

  Xu J; Wei C; Wang C; Li F; Wang Z; Xiong J; Zhou Y; Li S; Liu X; Yang G; Han L; Zhang J; Zhang S
• Review: NATURE REVIEWS CLINICAL ONCOLOGY. 2024;21(2):106-120

  Pharmacological reactivation of p53 in the era of precision anticancer medicine

  Tuval A; Strandgren C; Heldin A; Palomar-Siles M; Wiman KG
• Article: HELIYON. 2024;10(1):e23831

  Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage

  Mollick T; Darekar S; Dalarun B; Plastino F; Zhang J; Fernandez AP; Alkasalias T; Andre H; Lain S
• Article: ONCOIMMUNOLOGY. 2023;12(1):2175517

  CD25^bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression

  Chen Z; Tong L; Neo SY; Li S; Gao J; Schlisio S; Lundqvist A
• Article: RNA BIOLOGY. 2023;20(1):368-383

  Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

  Heldin A; Cancer M; Palomar-Siles M; Ohlin S; Zhang M; Sun-Zhang A; Mariani A; Liu J; Bykov VJN; Wiman KGG
• Article: PLOS ONE. 2023;18(11):e0292468

  Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

  Palomar-Siles M; Yurevych V; Bykov VJN; Wiman KG
• Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(20):e169671

  Antioxidants stimulate BACH1-dependent tumor angiogenesis

  Wang T; Dong Y; Huang Z; Zhang G; Zhao Y; Yao H; Hu J; Tueksammel E; Cai H; Liang N; Xu X; Yang X; Schmidt S; Qiao X; Schlisio S; Stromblad S; Qian H; Jiang C; Treuter E; Bergo MO
• Journal article: DEVELOPMENTAL CELL. 2023;58(19):1967-1982.e8

  Palbociclib releases the latent differentiation capacity of neuroblastoma cells

  Ferguson KM; Gillen SL; Chaytor L; Poon E; Marcos D; Gomez RL; Woods LM; Mykhaylechko L; Elfari L; da Costa BM; Jamin Y; Carroll JS; Chesler L; Ali FR; Philpott A
• Article: NATURE. 2023;618(7965):598-606

  Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

  Gavish A; Mints M; Greenwald AC; Hoefflin R; Simkin D; Tschernichovsky R; Galili Darnell N; Somech E; Barbolin C; Antman T; Kovarsky D; Barrett T; Gonzalez Castro LN; Halder D; Chanoch-Myers R; Laffy J; Mints M; Wider A; Tal R; Spitzer A; Hara T; Raitses-Gurevich M; Stossel C; Golan T; Tirosh A; Suva ML; Puram SV; Tirosh I
• Article: BMC MEDICINE. 2023;21(1):199

  MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury

  Zhang C; Wei C; Huang X; Hou C; Liu C; Zhang S; Zhao Z; Liu Y; Zhang R; Zhou L; Li Y; Yuan X; Zhang J
• Article: NATURE GENETICS. 2023;55(4):640-650

  Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

  Puram SV; Mints M; Pal A; Qi Z; Reeb A; Gelev K; Barrett TF; Gerndt S; Liu P; Parikh AS; Ramadan S; Law T; Mroz EA; Rocco JW; Adkins D; Thorstad WL; Gay HA; Ding L; Paniello RC; Pipkorn P; Jackson RS; Wang X; Mazul A; Chernock R; Zevallos JP; Silva-Fisher J; Tirosh I
• Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(7):6499

  Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging

  Smith N; Shirazi S; Cakouros D; Gronthos S
• Corrigendum: ONCOGENE. 2023;42(9):709

  Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s (vol 33, pg 4407, 2014)

  Bersani C; Xu L-D; Vilborg A; Lui W-O; Wiman KG
• Article: FRONTIERS IN ONCOLOGY. 2022;12:1055371

  PLK4 initiates crosstalk between cell cycle, cell proliferation and macrophages infiltration in gliomas

  Zhang X; Li Z; Wei C; Luo L; Li S; Zhou J; Liang H; Li Y; Han L
• Journal article: FRONTIERS IN IMMUNOLOGY. 2022;13:1058036

  Polo-like kinase 1 is related with malignant characteristics and inhibits macrophages infiltration in glioma

  Luo L; Zhang X-Y; Zhen Y-W; Guo G-C; Peng D-Z; Wei C; Pei D-L; Yu B; Ji Y-C; Liu X-Z; Han L; Zhang Z-Y
• Corrigendum: CELL DEATH DISCOVERY. 2022;8(1):472

  Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells (vol 15, pg 548, 2022)

  Alkasalias T; Zhang J; Madapura H; Dalarun B; Reina OB; Lewensohn R; Viktorsson K; Salihi A; Darekar S; Lain S
• Article: CELL DEATH & DISEASE. 2022;13(11):997

  Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

  Palomar-Siles M; Heldin A; Zhang M; Strandgren C; Yurevych V; van Dinter JT; Engels SAG; Hofman DA; Ohlin S; Meineke B; Bykov VJN; van Heesch S; Wiman KG
• Article: CELL DEATH DISCOVERY. 2022;8(1):464

  Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells

  Alkasalias T; Zhang J; Madapura H; Dalarun B; Reina OB; Lewensohn R; Viktorsson K; Salihi A; Darekar S; Lain S
• Article: ISCIENCE. 2022;25(11):105317

  Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer

  Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
• Article: CELL DEATH & DISEASE. 2022;13(11):942

  LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway

  Wei C; Zhang X; Peng D; Zhang X; Guo H; Lu Y; Luo L; Wang B; Li Z; He Y; Du X; Zhang S; Liang H; Li S; Wang S; Han L; Zhang J
• Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6545

  HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection (vol 13, 5093, 2022)

  Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
• Article: HAEMATOLOGICA. 2022;107(11):2548-2561

  Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia

  Tuval A; Brilon Y; Azogy H; Moskovitz Y; Leshkowitz D; Salame TM; Minden MD; Tal P; Rotter V; Oren M; Kaushansky N; Shlush LI
• Corrigendum: NATURE METABOLISM. 2022;4(10):1421

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Article: NATURE COMMUNICATIONS. 2022;13(1):5093

  HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection

  Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
• Corrigendum: CELL DEATH & DISEASE. 2022;13(8):672

  Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells (vol 12, 709, 2021)

  Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
• Doctoral thesis: 2022

  Exploring inter- and intra-heterogeneity in childhood neuroblastoma and pheochromocytoma

  Li W
• Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(8):e886

  Screening of cell-virus, cell-cell, gene-gene crosstalk among animal kingdom at single cell resolution

  Chen D; Ou Z; Zhu J; Wang H; Ding P; Luo L; Ding X; Sun C; Lan T; Sahu SK; Wu W; Yuan Y; Wu W; Qiu J; Zhu Y; Yue Q; Jia Y; Wei Y; Qin Q; Li R; Zhao W; Lv Z; Pu M; Lv B; Yang S; Chang A; Wei X; Chen F; Yang T; Wei Z; Yang F; Zhang P; Guo G; Li Y; Hua Y; Liu H
• Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022;41(1):226

  Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma

  Sainero-Alcolado L; Mushtaq M; Liano-Pons J; Rodriguez-Garcia A; Yuan Y; Liu T; Ruiz-Perez MV; Schlisio S; Bedoya-Reina O; Arsenian-Henriksson M
• Journal article: CELL DEATH DISCOVERY. 2022;8(1):325

  The role of N6-methyladenosine-modified non-coding RNAs in the pathological process of human cancer

  Luo L; Zhen Y; Peng D; Wei C; Zhang X; Liu X; Han L; Zhang Z
• Journal article: BIOMEDICINE & PHARMACOTHERAPY. 2022;151:113150

  CircRNA: An emerging star in the progression of glioma

  Peng D; Luo L; Zhang X; Wei C; Zhang Z; Han L
• Journal article: FRONTIERS IN IMMUNOLOGY. 2022;13:944740

  Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas (vol 13, 849592, 2022)

  Wei C; Wang B; Peng D; Zhang X; Li Z; Luo L; He Y; Liang H; Du X; Li S; Zhang S; Zhang Z; Han L; Zhang J
• Article: NATURE METABOLISM. 2022;4(6):739-758

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Preprint: RESEARCH SQUARE. 2022

  LncRNA HOXA11-AS promotes gliomas malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway

  Wei C; Zhang X; Peng D; Lu Y; Luo L; Wang B; Li Z; He Y; Du X; Zhang S; Liang H; Li S; Wang S; Han L; Zhang J
• Article: FRONTIERS IN IMMUNOLOGY. 2022;13:849592

  Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas

  Wei C; Wang B; Peng D; Zhang X; Li Z; Luo L; He Y; Liang H; Du X; Li S; Zhang S; Zhang Z; Han L; Zhang J
• Preprint: RESEARCH SQUARE. 2022

  Polo-like kinase 1 plays an oncogenic role in pan-cancer based on bioinformatics and biological assays

  Luo L; Zhang X-Y; Zhen Y-W; Liu Z; Peng D-Z; Wei C; Liu X-Z; Han L; Zhang Z-Y
• Article: CELL DEATH & DISEASE. 2022;13(3):214

  Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

  Zhang Q; Balourdas D-I; Baron B; Senitzki A; Haran TE; Wiman KG; Soussi T; Joerger AC
• Article: NUCLEIC ACIDS RESEARCH. 2022;50(2):867-884

  Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon.

  Fefelova EA; Pleshakova IM; Mikhaleva EA; Pirogov SA; Poltorachenko VA; Abramov YA; Romashin DD; Shatskikh AS; Blokh RS; Gvozdev VA; Klenov MS
• Article: NUCLEIC ACIDS RESEARCH. 2022;50(D1):D934-D942

  VThunter: a database for single-cell screening of virus target cells in the animal kingdom

  Chen D; Tan C; Ding P; Luo L; Zhu J; Jiang X; Ou Z; Ding X; Lan T; Zhu Y; Jia Y; Wei Y; Li R; Qin Q; Sun C; Zhao W; Lv Z; Wang H; Wu W; Yuan Y; Pu M; Li Y; Zhang Y; Chang A; Guo G; Bai Y; Jin X; Liu H
• Preprint: SSRN ELECTRONIC JOURNAL. 2022

  Targeting Myeloid Suppressive Cells Revives Cytotoxic Anti-Tumor Responses in Pancreatic Cancer

  Sarhan D; Eisinger S; Pelicano C; Fei H; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Önfelt B; Schlisio S; Ravetch JV; Heuchel R; Löhr MJ; Karlsson MCI
• Journal article: EXPERIMENTAL HEMATOLOGY. 2022;111:s151-s152

  3214 – DNMT3A R882 MUTATION IN HUMAN HAEMATOPOIETIC STEM CELLS ALTERS DIFFERENTIATION TOWARDS NEUTROPHILS AND MONOCYTES

  Vedi A; Hayler D; Biezuner T; Mitchell E; Sham K; Krzywon A; Bastos H; Lee J; Tuval A; Danin A; Chapal N; Santoro A; Moskovitz Y; Minden M; Arruda A; Nangalia J; Campbell P; Shlush L; Laurenti E
• Conference publication: EXPERIMENTAL HEMATOLOGY. 2022;111:S151

  DNMT3A R882 MUTATION IN HUMAN HAEMATOPOIETIC STEM CELLS ALTERS DIFFERENTIATION TOWARDS NEUTROPHILS AND MONOCYTES

  Vedi A; Hayler D; Biezuner T; Mitchell E; Sham K; Krzywon A; Bastos H; Lee J; Tuval A; Danin A; Chapal N; Santoro A; Moskovitz Y; Minden M; Arruda A; Nangalia J; Campbell P; Shlush L; Laurenti E
• Article: CANCERS. 2021;14(1):77

  Whole-Exome Sequencing of HPV Positive Tonsillar and Base of Tongue Squamous Cell Carcinomas Reveals a Global Mutational Pattern along with Relapse-Specific Somatic Variants

  aehrlund-Richter A; Holzhauser S; Dalianis T; Naesman A; Mints M
• Article: NATURE COMMUNICATIONS. 2021;12(1):7083

  Single cell atlas for 11 non-model mammals, reptiles and birds

  Chen D; Sun J; Zhu J; Ding X; Lan T; Wang X; Wu W; Ou Z; Zhu L; Ding P; Wang H; Luo L; Xiang R; Wang X; Qiu J; Wang S; Li H; Chai C; Liang L; An F; Zhang L; Han L; Zhu Y; Wang F; Yuan Y; Wu W; Sun C; Lu H; Wu J; Sun X; Zhang S; Sahu SK; Liu P; Xia J; Zhang L; Chen H; Fang D; Zeng Y; Wu Y; Cui Z; He Q; Jiang S; Ma X; Feng W; Xu Y; Li F; Liu Z; Chen L; Chen F; Jin X; Qiu W; Wang T; Li Y; Xing X; Yang H; Xu Y; Hua Y; Liu Y; Liu H; Xu X
• Journal article: BLOOD. 2021;138:2162

  DNMT3A R882 Mutation in Human Haematopoietic Stem Cells Alters Differentiation Towards Neutrophils and Monocytes

  Vedi A; Hayler D; Biezuner T; Santoro A; Sham K; Tuval A; Danin A; Moskovitz Y; Shlush LI; Laurenti E
• Article: CANCER CELL INTERNATIONAL. 2021;21(1):566

  Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers

  Peng D; Wei C; Zhang X; Li S; Liang H; Zheng X; Jiang S; Han L
• Article: NATURE COMMUNICATIONS. 2021;12(1):5309

  Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

  Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
• Article: SCIENCE BULLETIN. 2021;66(14):1448-1461

  Single-cell atlas of domestic pig cerebral cortex and hypothalamus

  Zhu J; Chen F; Luo L; Wu W; Dai J; Zhong J; Lin X; Chai C; Ding P; Liang L; Wang S; Ding X; Chen Y; Wang H; Qiu J; Wang F; Sun C; Zeng Y; Fang J; Jiang X; Liu P; Tang G; Qiu X; Zhang X; Ruan Y; Jiang S; Li J; Zhu S; Xu X; Li F; Liu Z; Cao G; Chen D
• Article: CELL DEATH & DISEASE. 2021;12(7):709

  Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

  Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
• Article: CANCERS. 2021;13(13):3242

  Proteomic Profiling of Tissue Exosomes Indicates Continuous Release of Malignant Exosomes in Urinary Bladder Cancer Patients, Even with Pathologically Undetectable Tumour

  Eldh M; Mints M; Hiltbrunner S; Ladjevardi S; Alamdari F; Johansson M; Jakubczyk T; Veerman RE; Winqvist O; Sherif A; Gabrielsson S
• Preprint: RESEARCH SQUARE. 2021

  Study of MiR-451 in the Treatment of Human Gliomas through Regulating the AMPK Pathway Mediated by Bone Mesenchymal Stem Cells

  Zhen Y; Wei C; Zhang X; Gao P; Peng D; Guo H; Han L; Nan Y; Yan D; Zhong Y
• Preprint: BIORXIV. 2021

  Pseudo-mutant p53 as a targetable phenotype of DNMT3A -mutated pre-leukemia

  Tuval A; Brilon Y; Azogy H; Moshkovitz Y; Biezuner T; Leshkowitz D; Salame T; Minden M; Tal P; Rotter V; Oren M; Kaushansky N; Shlush L
• Article: JOURNAL OF GENETICS AND GENOMICS. 2021;48(5):411-425

  A high-resolution cell atlas of the domestic pig lung and an online platform for exploring lung single-cell data

  Zhang L; Zhu J; Wang H; Xia J; Liu P; Chen F; Jiang H; Miao Q; Wu W; Zhang L; Luo L; Jiang X; Bai Y; Sun C; Chen D; Zhang X
• Article: CELL DEATH AND DIFFERENTIATION. 2021;28(5):1477-1492

  Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

  Doffe F; Carbonnier V; Tissier M; Leroy B; Martins I; Mattsson JSM; Micke P; Pavlova S; Pospisilova S; Smardova J; Joerger AC; Wiman KG; Kroemer G; Soussi T
• Article: JOURNAL OF GENETICS AND GENOMICS. 2021;48(4):277-288

  Single-cell brain atlas of Parkinson's disease mouse model

  Zhong J; Tang G; Zhu J; Wu W; Li G; Lin X; Liang L; Chai C; Zeng Y; Wang F; Luo L; Li J; Chen F; Huang Z; Zhang X; Zhang Y; Liu H; Qiu X; Tang S; Chen D
• Journal article: EXPERIMENTAL NEUROLOGY. 2021;338:113606

  Single- and two- chain tissue type plasminogen activator treatments differentially influence cerebral recovery after stroke

  Anfray A; Brodin C; Drieu A; Potzeha F; Dalarun B; Agin V; Vivien D; Orset C
• Preprint: BIORXIV. 2021

  Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors

  Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
• Article: NUCLEIC ACIDS RESEARCH. 2021;49(5):2509-2521

  Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors

  Shi Y; Yuan J; Rraklli V; Maxymovitz E; Cipullo M; Liu M; Li S; Westerlund I; Bedoya-Reina OC; Bullova P; Rorbach J; Juhlin CC; Stenman A; Larsson C; Kogner P; O'Sullivan MJ; Schlisio S; Holmberg J
• Review: FRONTIERS IN ONCOLOGY. 2021;11:587554

  Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy

  Zhang X; Wei C; Liang H; Han L
• Article: CANCERS. 2021;13(6):1230

  Single-Cell Deconvolution of Head and Neck Squamous Cell Carcinoma.

  Qi Z; Liu Y; Mints M; Mullins R; Sample R; Law T; Barrett T; Mazul AL; Jackson RS; Kang SY; Pipkorn P; Parikh AS; Tirosh I; Dougherty J; Puram SV
• Article: MOLECULAR BIOLOGY. 2021;55(2):305-311

  [Template Properties of 5-Methyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxycytidine in Reactions with Human Translesion and Reparative DNA Polymerases].

  Shilkin ES; Petrova DV; Poltorachenko VA; Boldinova EO; Zharkov DO; Makarova AV
• Article: CANCER BIOLOGY & MEDICINE. 2021;18(1):139-154

  VEGFR2 inhibition hampers breast cancer cell proliferation via enhanced mitochondrial biogenesis

  Ni H; Guo M; Zhang X; Jiang L; Tan S; Yuan J; Cui HL; Min Y; Zhang J; Schlisio S; Ma C; Liao W; Nister M; Chen C; Li S; Li N
• Letter: CANCER CELL. 2021;39(2):134-135

  Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

  Bedoya-Reina OC; Schlisio S
• Article: EMBO MOLECULAR MEDICINE. 2021;13(2):e10852

  A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

  Ceder S; Eriksson SE; Cheteh EH; Dawar S; Corrales Benitez M; Bykov VJN; Fujihara KM; Grandin M; Li X; Ramm S; Behrenbruch C; Simpson KJ; Hollande F; Abrahmsen L; Clemons NJ; Wiman KG
• Article: SCIENTIFIC REPORTS. 2021;11(1):1782

  Tumour inflammation signature and expression of S100A12 and HLA class I improve survival in HPV-negative hypopharyngeal cancer

  Mints M; Landin D; Nasman A; Mirzaie L; Ursu RG; Zupancic M; Marklund L; Dalianis T; Munck-Wikland E; Ramqvist T
• Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(6):e12926

  IL-16 processing in sentinel node regulatory T cells is a factor in bladder cancer immunity

  Krantz D; Mints M; Winerdal M; Riklund K; Rutishauser D; Zubarev R; Zirakhzadeh AA; Alamdari F; Johansson M; Sherif A; Winqvist O
• Article: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2020;42(11):3206-3217

  Immune related proteins and tumor infiltratingCD8+lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome

  Landin D; Ahrlund-Richter A; Mirzaie L; Mints M; Nasman A; Kolev A; Marklund L; Dalianis T; Munck-Wikland E; Ramqvist T
• Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(10):2685-2700

  Platelet factor 4 enhances CD4⁺T effector memory cell responses via Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis

  Tan S; Li S; Min Y; Gistera A; Moruzzi N; Zhang J; Sun Y; Andersson J; Malmstrom RE; Wang M; Berggren P-O; Schlisio S; Liao W; Ketelhuth DFJ; Ma C; Li N
• Editorial: CANCER COMMUNICATIONS. 2020;40(9):453-455

  Nasopharyngeal carcinoma joins the single-cell party.

  Mints M; Tirosh I
• Article: HIP INTERNATIONAL. 2020;30(4):469-473

  Undersizing the Exeter stem in hip hemiarthroplasty increases the risk of periprosthetic fracture.

  Korsnes L; Gottvall A; Buttazzoni C; Mints M
• Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(12):E4299-4299

  CAIX-Mediated Control of LIN28/let-7Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia

  Gibadulinova A; Bullova P; Strnad H; Pohlodek K; Jurkovicova D; Takacova M; Pastorekova S; Svastova E
• Article: CELL DEATH DISCOVERY. 2020;6(1):42

  Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

  Cheteh EH; Sarne V; Ceder S; Bianchi J; Augsten M; Rundqvist H; Egevad L; Ostman A; Wiman KG
• Review: ONCOLOGY REPORTS. 2020;43(6):1737-1754

  Recent advances in unraveling the molecular mechanisms and functions of HOXA11-AS in human cancers and other diseases

  Wei C; Zhao L; Liang H; Zhen Y; Han L
• Article: SCIENTIFIC REPORTS. 2020;10(1):5960

  Urinary Exosomes from Bladder Cancer Patients Show a Residual Cancer Phenotype despite Complete Pathological Downstaging

  Hiltbrunner S; Mints M; Eldh M; Rosenblatt R; Holmstrom B; Alamdari F; Johansson M; Veerman RE; Winqvist O; Sherif A; Gabrielsson S
• Journal article: AGING-US. 2020;12(7):5781-5791

  A novel germline gain-of-function HIF2A mutation in hepatocellular carcinoma with polycytnemia

  Yu J; Shi X; Yang C; Bullova P; Hong CS; Nesvick CL; Dmitriev P; Pacak K; Zhuang Z; Cao H; Li L
• Preprint: BIORXIV. 2019

  Alternative splicing in neuroblastoma generates RNA-fusion transcripts and is associated with vulnerability to spliceosome inhibitors

  Shi Y; Rraklli V; Maxymovitz E; Li S; Westerlund I; Bedoya-Reina O; Yuan J; Bullova P; Juhlin C; Stenman A; Larsson C; Kogner P; O’Sullivan M; Schlisio S; Holmberg J
• Journal article: ELIFE. 2019;8:e45789

  Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

  Clark DJ; McMillan LE; Tan SL; Bellomo G; Massoue C; Thompson H; Mykhaylechko L; Alibhai D; Ruan X; Singleton KL; Du M; Hedges A; Schwartzberg PL; Verkade P; Murphy RF; Wulfing C
• Corrigendum: CELL DEATH & DISEASE. 2019;10(10):769

  APR-246 reactivates mutant p53 by targeting cysteines 124 and 277 (vol 9, 439, 2018)

  Zhang Q; Bykov VJN; Wiman KG; Zawacka-Pankau J
• Article: CLINICAL GENETICS. 2019;96(3):216-225

  Functional characterization of novel germline TP53 variants in Swedish families

  Kharaziha P; Ceder S; Axell O; Krall M; Fotouhi O; Bohm S; Lain S; Borg A; Larsson C; Wiman KG; Tham E; Bajalica-Lagercrantz S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006

  EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

  Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nister M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WGJ; Schlisio S
• Review: EXPERT OPINION ON BIOLOGICAL THERAPY. 2019;19(8):811-827

  Facing the future: challenges and opportunities in adoptive T cell therapy in cancer.

  Magalhaes I; Carvalho-Queiroz C; Hartana CA; Kaiser A; Lukic A; Mints M; Nilsson O; Grönlund H; Mattsson J; Berglund S
• Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):e14712

  Impact of combined MRP1 inhibition and mutant p53 targeting compound APR-246

  Ceder AS; Eriksson SE; Cheteh EH; Bykov VJN; Abrahmsen L; Wiman KG
• Review: HAEMATOLOGICA. 2019;104(5):872-880

  Evolutionary trajectory of leukemic clones and its clinical implications

  Tuval A; Shlush LI
• Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(4):330-341

  p53 as a hub in cellular redox regulation and therapeutic target in cancer

  Eriksson SE; Ceder S; Bykov VJN; Wiman KG
• Journal article: CANCER LETTERS. 2019;443:91-107

  PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma

  Zhang Z; Wang Z; Huang K; Liu Y; Wei C; Zhou J; Zhang W; Wang Q; Liang H; Zhang A; Wang G; Zhen Y; Han L
• Article: TRANSLATIONAL ONCOLOGY. 2018;11(6):1343-1349

  The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

  Synnott NC; Madden SF; Bykov VJN; Crown J; Wiman KG; Duffy MJ
• Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2018;88(6):e12722

  CCR2 upregulated on peripheral T cells in osteoarthritis but not in bone marrow

  Arkestal K; Mints M; Enocson A; Linton L; Marits P; Glise H; Andersson J; Winqvist O
• Article: CELL CHEMICAL BIOLOGY. 2018;25(10):1219-1230.e3

  Role of Thiol Reactivity for Targeting Mutant p53

  Zhang Q; Bergman J; Wiman KG; Bykov VJN
• Journal article: PLOS BIOLOGY. 2018;16(9):e3000030

  Correction: WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies.

  Mahmoudi S; Henriksson S; Weibrecht I; Smith S; Söderberg O; Strömblad S; Wiman KG; Farnebo M
• Article: SCIENTIFIC REPORTS. 2018;8(1):12671

  Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

  Haffo L; Lu J; Bykov VJN; Martin SS; Ren X; Coppo L; Wiman KG; Holmgren A
• Article: CELL REPORTS. 2018;24(5):1316-1329

  PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

  Rodriguez J; Herrero A; Li S; Rauch N; Quintanilla A; Wynne K; Krstic A; Acosta JC; Taylor C; Schlisio S; von Kriegsheim A
• Journal article: CLINICAL CANCER RESEARCH. 2018;24(14):3423-3432

  Targeting NAD⁺/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma

  Pang Y; Lu Y; Caisova V; Liu Y; Bullova P; Thanh-Truc H; Zhou Y; Yu D; Frysak Z; Hartmann I; Taieb D; Pacak K; Yang C
• Conference publication: CANCER RESEARCH. 2018;78(13):5853

  Targeting NAD⁺/PARP DNA repair pathway as a novel therapeutic approach to SDHB-mutated cluster I pheochromocytoma and paraganglioma

  Pang Y; Lu Y; Caisova V; Liu Y; Bullova P; Thanh-Truc H; Frysak Z; Hartmann I; Taieb D; Pacak K; Yang C
• Article: ORAL ONCOLOGY. 2018;82:8-16

  MicroRNA-155,-185 and-193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma

  Bersani C; Mints M; Tertipis N; Haeggblom L; Nasman A; Romanitan M; Dalianis T; Ramqvist T
• Article: BLOOD. 2018;131(24):2670-2681

  Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma

  Ren W; Ye X; Su H; Li W; Liu D; Pirmoradian M; Wang X; Zhang B; Zhang Q; Chen L; Nie M; Liu Y; Meng B; Huang H; Jiang W; Zeng Y; Li W; Wu K; Hou Y; Wiman KG; Li Z; Zhang H; Peng R; Zhu S; Pan-Hammarstrom Q
• Article: CELL DEATH & DISEASE. 2018;9(5):439

  APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

  Zhang Q; Bykov VJN; Wiman KG; Zawacka-Pankau J
• Article: BRAIN RESEARCH. 2018;1683:27-35

  Involvement of mGluR I in EphB/ephrinB reverse signaling activation induced retinal ganglion cell apoptosis in a rat chronic hypertension model

  Zhao Y; Li Q; Li X-Y; Cui P; Gao F; Zhu K; Li L-Z; Sun X-H; Wang Z
• Review: NATURE REVIEWS CANCER. 2018;18(2):89-102

  Targeting mutant p53 for efficient cancer therapy

  Bykov VJN; Eriksson SE; Bianchi J; Wiman KG
• Article: FRONTIERS IN ONCOLOGY. 2018;7:323

  Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

  Zhang M; Heldin A; Palomar-Siles M; Ohlin S; Bykov VJN; Wiman KG
• Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(51):E10859-E10860

  High levels of EPAS1 are closely associated with key features of low-risk neuroblastoma

  Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Sodersten E; Schlisio S; Holmberg J
• Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(48):19607

  Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs (vol 280, pg 30384, 2005)

  Bykov VJN; Issaeva N; Zache N; Shilov A; Hultcrantz M; Bergman J; Selivanova G; Wiman KG
• Journal article: ENDOCRINOLOGY. 2017;158(10):3097-3108

  Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice

  Bullova P; Cougnoux A; Marzouca G; Kopacek J; Pacak K
• Journal article: ONCOTARGET. 2017;8(34):56110-56125

  Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha

  Zhang C; Yang C; Feldman MJ; Wang H; Pang Y; Maggio DM; Zhu D; Nesvick CL; Dmitriev P; Bullova P; Chittiboina P; Brady RO; Pacak K; Zhuang Z
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6137-E6146

  Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression

  Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Surova O; Sodersten E; Kogner P; Nyman U; Schlisio S; Holmberg J
• Article: NEUROSCIENCE. 2017;355:71-83

  ACTIVATION OF DOPAMINE D1 RECEPTORS ENHANCES THE TEMPORAL SUMMATION AND EXCITABILITY OF RAT RETINAL GANGLION CELLS

  Cui P; Li X-Y; Zhao Y; Li Q; Gao F; Li L-Z; Yin N; Sun X-H; Wang Z
• Article: CELL DEATH & DISEASE. 2017;8(6):e2848

  Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

  Cheteh EH; Augsten M; Rundqvist H; Bianchi J; Sarne V; Egevad L; Bykov VJN; Ostman A; Wiman KG
• Article: ONCOTARGET. 2017;8(21):35339-35350

  Targeted sequencing of tonsillar and base of tongue cancer and human papillomavirus positive unknown primary of the head and neck reveals prognostic effects of mutated FGFR3

  Bersani C; Sivars L; Haeggblom L; DiLorenzo S; Mints M; Ahrlund-Richter A; Tertipis N; Munck-Wikland E; Nasman A; Ramqvist T; Dalianis T
• Article: GENES & DEVELOPMENT. 2017;31(10):1036-1053

  Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA

  Fell SM; Li S; Wallis K; Kock A; Surova O; Rraklli V; Hoefig CS; Li W; Mittag J; Henriksson MA; Kenchappa RS; Holmberg J; Kogner P; Schlisio S
• Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):483-495

  Understanding cell cycle and cell death regulation provides novel weapons against human diseases

  Wiman KG; Zhivotovsky B
• Editorial: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):418-421

  Introduction to Nobel Conference: 'The Cell Cycle and Cell Death in Disease'

  Wiman KG; Zhivotovsky B
• Article: ORAL ONCOLOGY. 2017;68:53-59

  A model using concomitant markers for predicting outcome in human papillomavirus positive oropharyngeal cancer

  Bersani C; Mints M; Tertipis N; Haeggblom L; Sivars L; Ahrlund-Richter A; Vlastos A; Smedberg C; Grun N; Munck-Wikland E; Nasman A; Ramqvist T; Dalianis T
• Corrigendum: CELL DEATH & DISEASE. 2017;8(4):e2751

  APR-246/PRIMA-1^MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase (vol 4, e881, 2013)

  Peng X; Zhang M-Q; Conserva F; Hosny G; Selivanova G; Bykov VJN; Arner ESJ; Wiman KG
• Journal article: ONCOTARGET. 2017;8(14):22313-22324

  Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

  Ying P; Yang C; Schovanek J; Wang H; Bullova P; Caisova V; Gupta G; Wolf KI; Semenza GL; Zhuang Z; Pacak K
• Article: NATURE COMMUNICATIONS. 2017;8:14844

  Inhibiting the system x_(C)over-bar/glutathione axis selectively targets cancers with mutant-p53 accumulation

  Liu DS; Duong CP; Haupt S; Montgomery KG; House CM; Azar WJ; Pearson HB; Fisher OM; Read M; Guerra GR; Haupt Y; Cullinane C; Wiman KG; Abrahmsen L; Phillips WA; Clemons NJ
• Article: BRAIN STRUCTURE & FUNCTION. 2017;222(2):813-830

  Activation of group I metabotropic glutamate receptors regulates the excitability of rat retinal ganglion cells by suppressing Kir and I _h

  Li Q; Cui P; Miao Y; Gao F; Li X-Y; Qian W-J; Jiang S-X; Wu N; Sun X-H; Wang Z
• Journal article: MOLECULAR CELL. 2016;64(5):1009

  Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage (vol 33, pg 462, 2009)

  Mahmoudi S; Henriksson S; Corcoran M; Mendez-Vidal C; Wiman KG; Farnebo M
• Article: BIOLOGICAL TRACE ELEMENT RESEARCH. 2016;173(2):345-353

  Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats

  Liu Y; Qiu C; Li W; Mu W; Li C; Guo M
• Journal article: ONCOTARGET. 2016;7(26):40531-40545

  Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models

  Bullova P; Cougnoux A; Abunimer L; Kopacek J; Pastorekova S; Pacak K
• Article: ONCOTARGET. 2016;7(23):34229-34239

  XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis

  Choo Z; Koh RYL; Wallis K; Koh TJW; Kuick CH; Sobrado V; Kenchappa RS; Loh AHP; Soh SY; Schlisio S; Chang KTE; Chen ZX
• Article: BIOLOGICAL TRACE ELEMENT RESEARCH. 2016;171(2):371-379

  Selenium Induces an Anti-tumor Effect Via Inhibiting Intratumoral Angiogenesis in a Mouse Model of Transplanted Canine Mammary Tumor Cells

  Li W; Guo M; Liu Y; Mu W; Deng G; Li C; Qiu C
• Article: JOURNAL OF OVARIAN RESEARCH. 2016;9(1):27

  Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

  Fransson A; Glaessgen D; Alfredsson J; Wiman KG; Bajalica-Lagercrantz S; Mohell N
• Article: CELL CYCLE. 2016;15(9):1267-1275

  cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response

  Madapura HS; Salamon D; Wiman KG; Lain S; Klein E; Nagy N
• Journal article: ENDOCRINE-RELATED CANCER. 2016;23(5):L13-L16

  HIF2A gain-of-function mutations detected in duodenal gangliocytic paraganglioma

  Zhuang Z; Yang C; Ryska A; Ji Y; Hou Y; Graybill SD; Bullova P; Lubensky IA; Kloeppel G; Pacak K
• Article: BRAIN RESEARCH. 2016;1635:95-104

  Suppression of outward K⁺ currents by activating dopamine D1 receptors in rat retinal ganglion cells through PKA and CaMKII signaling pathways

  Li Q; Wu N; Cui P; Gao F; Qian W-J; Miao Y; Sun X-H; Wang Z
• Meeting abstract: CANCER RESEARCH. 2016;76:a47

  Unusual suspects identified in neuroblastoma: An unexpected tumor suppression pathway

  Choo Z; Koh RYL; Wallis K; Koh TJW; Kuick CH; Sobrado V; Loh AHP; Soh SY; Schlisio S; Chang KTE; Chen ZX
• Review: FRONTIERS IN ONCOLOGY. 2016;6:21

  Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

  Bykov VJN; Zhang Q; Zhang M; Ceder S; Abrahmsen L; Wiman KG
• Journal article: ENDOCRINE PRACTICE. 2016;22(2):190-195

  AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2α SIGNALING

  Isaacson B; Bullova P; Frone M; Click A; Hamplova B; Rabaglia J; Woodruff S; Nwariaku F; Kathuria A; Pacak K; Ghayee HK
• Article: DEVELOPMENTAL CELL. 2016;36(2):164-178

  The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis

  Li S; Fell SM; Surova O; Smedler E; Wallis K; Chen ZX; Hellman U; Johnsen JI; Martinsson T; Kenchappa RS; Uhlen P; Kogner P; Schlisio S
• Article: ONCOTARGET. 2016;7(2):1895-1911

  Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis

  Bersani C; Huss M; Giacomello S; Xu L-D; Bianchi J; Eriksson S; Jerhammar F; Alexeyenko A; Vilborg A; Lundeberg J; Lui W-O; Wiman KG
• Article: HYPOXIA (AUCKL). 2016;4:15-27

  The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

  Koivunen P; Fell SM; Lu W; Rabinowitz JD; Kung AL; Schlisio S
• Journal article: AACE CLINICAL CASE REPORTS. 2016;2(3):e176-e181

  Functional Imaging Experience in a Germline Fumarate Hydratase Mutation–Positive Patient With Pheochromocytoma and Paraganglioma

  Nambuba J; Därr R; Janssen I; Bullova P; Adams KT; Millo C; Bourdeau I; Kassai A; Yang C; Kebebew E; Zhuang Z; Pacak K
• Article: BIOLOGICAL TRACE ELEMENT RESEARCH. 2016;169(1):86-93

  Protective Role of Selenium Compounds on the Proliferation, Apoptosis, and Angiogenesis of a Canine Breast Cancer Cell Line

  Liu Y; Li W; Guo M; Li C; Qiu C
• Article: ORAL ONCOLOGY. 2015;51(12):1126-1131

  Studies on human papillomavirus (HPV) 16 E2, E5 and E7 mRNA in HPV-positive tonsillar and base of tongue cancer in relation to clinical outcome and immunological parameters

  Ramqvist T; Mints M; Tertipis N; Nasman A; Romanitan M; Dalianis T
• Journal article: ENDOCRINOLOGY. 2015;156(11):4094-4104

  Inhibitory Effect of the Noncamptothecin Topoisomerase I Inhibitor LMP-400 on Female Mice Models and Human Pheochromocytoma Cells

  Schovanek J; Bullova P; Tayem Y; Giubellino A; Wesley R; Lendvai N; Noelting S; Kopacek J; Frysak Z; Pommier Y; Kummar S; Pacak K
• Doctoral thesis: 2015

  Methodological approaches towards personalised cancer medicine

  Mints M
• Article: GUT. 2015;64(10):1506-1516

  APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

  Liu DSH; Read M; Cullinane C; Azar WJ; Fennell CM; Montgomery KG; Haupt S; Haupt Y; Wiman KG; Duong CP; Clemons NJ; Phillips WA
• Review: CELL DEATH AND DIFFERENTIATION. 2015;22(8):1239-1249

  TP53: an oncogene in disguise

  Soussi T; Wiman KG
• Article: CELL DEATH & DISEASE. 2015;6(6):e1794

  APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

  Mohell N; Alfredsson J; Fransson A; Uustalu M; Bystrom S; Gullbo J; Hallberg A; Bykov VJN; Bjorklund U; Wiman KG
• Journal article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(5):E710-E719

  Pituitary Adenoma With Paraganglioma/Pheochromocytoma (3PAs) and Succinate Dehydrogenase Defects in Humans and Mice

  Xekouki P; Szarek E; Bullova P; Giubellino A; Quezado M; Mastroyannis SA; Mastorakos P; Wassif CA; Raygada M; Rentia N; Dye L; Cougnoux A; Koziol D; Sierra MDLL; Lyssikatos C; Belyavskaya E; Malchoff C; Moline J; Eng C; Maher LJIII; Pacak K; Lodish M; Stratakis CA
• Journal article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2015;93(1):93-104

  Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia

  Yang C; Zhuang Z; Fliedner SMJ; Shankavaram U; Sun MG; Bullova P; Zhu R; Elkahloun AG; Kourlas PJ; Merino M; Kebebew E; Pacak K
• Article: PLOS ONE. 2014;9(11):e111125

  Expression of the p53 Target Wig-1 Is Associated with HPV Status and Patient Survival in Cervical Carcinoma

  Xu L-D; Muller S; Thoppe SR; Hellborg F; Kanter L; Lerner M; Zheng B; Lagercrantz SB; Grander D; Wallin KL; Wiman KG; Larsson C; Andersson S
• Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:135

  RNA helicase A is essential for 1p36 gene KIF1 Bβ tumor suppression in neuroblastomas

  Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Choo Z; Hellman U; Sandberg R; Kenchappa RS; Martinsson T; Johnsen JI; Kogner P; Schlisio S
• Article: ONCOGENE. 2014;33(35):4407-4417

  Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ

  Bersani C; Xu L-D; Vilborg A; Lui W-O; Wiman KG
• Review: FEBS LETTERS. 2014;588(16):2622-2627

  Mutant p53 reactivation by small molecules makes its way to the clinic

  Bykov VJN; Wiman KG
• Journal article: ENDOCRINOLOGY. 2014;155(7):2377-2390

  Combination of 13-Cis Retinoic Acid and Lovastatin: Marked Antitumor Potential In Vivo in a Pheochromocytoma Allograft Model in Female Athymic Nude Mice

  Noelting S; Giubellino A; Tayem Y; Young K; Lauseker M; Bullova P; Schovanek J; Anver M; Fliedner S; Korbonits M; Goeke B; Vlotides G; Grossman A; Pacak K
• Article: EXPERIMENTAL ONCOLOGY. 2014;36(2):67-71

  Impact of combinations of EGF, TGFβ, 17β-oestradiol, and inhibitors of corresponding pathways on proliferation of breast cancer cell lines.

  Mints M; Souchelnytskyi S
• Journal article: PLOS ONE. 2014;9(4):e90458

  High-Throughput Screening for the Identification of New Therapeutic Options for Metastatic Pheochromocytoma and Paraganglioma

  Giubellino A; Shankavaram U; Bullova P; Schovanek J; Zhang Y; Shen M; Patel N; Elkahloun A; Lee M-J; Trepel J; Ferrer M; Pacak K
• Journal article: AMERICAN JOURNAL OF PATHOLOGY. 2014;184(4):953-965

  Expression Pattern of Carbonic Anhydrase IX in Medullary Thyroid Carcinoma Supports a Role for RET-Mediated Activation of the HIF Pathway

  Takacova M; Bullova P; Simko V; Skvarkova L; Poturnajova M; Feketeova L; Babal P; Kivela AJ; Kuopio T; Kopacek J; Pastorek J; Parkkila S; Pastorekova S
• Article: CANCER DISCOVERY. 2014;4(4):434-451

  RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma

  Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Hellman U; Sandberg R; Kenchappa RS; Martinson T; Johnsen JI; Kogner P; Schlisio S
• Journal article: ENDOCRINOLOGY. 2014;155(1):27-32

  Succinate-to-Fumarate Ratio as a New Metabolic Marker to Detect the Presence of SDHB/D-related Paraganglioma: Initial Experimental and Ex Vivo Findings

  Lendvai N; Pawlosky R; Bullova P; Eisenhofer G; Patocs A; Veech RL; Pacak K
• Article: GENES & DEVELOPMENT. 2014;28(1):58-70

  Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

  Kelly GL; Grabow S; Glaser SP; Fitzsimmons L; Aubrey BJ; Okamoto T; Valente LJ; Robati M; Tai L; Fairlie WD; Lee EF; Lindstrom MS; Wiman KG; Huang DCS; Bouillet P; Rowe M; Rickinson AB; Herold MJ; Strasser A
• Editorial: CELL DEATH AND DIFFERENTIATION. 2013;20(11):1438-1439

  p53 talks to PARP: the increasing complexity of p53-induced cell death

  Wiman KG
• Article: CELL DEATH & DISEASE. 2013;4(10):e881

  APR-246/PRIMA-1^MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

  Peng X; Zhang M-Q; Conserva F; Hosny G; Selivanova G; Bykov VJN; Arner ESJ; Wiman KG
• Journal article: PLOS ONE. 2013;8(2):e56083

  Targeting Heat Shock Protein 90 for the Treatment of Malignant Pheochromocytoma

  Giubellino A; Sourbier C; Lee M-J; Scroggins B; Bullova P; Landau M; Ying W; Neckers L; Trepel JB; Pacak K
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2152-2156

  Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1^MET

  Shalom-Feuerstein R; Serror L; Aberdam E; Mueller F-J; van Bokhoven H; Wiman KG; Zhou H; Aberdam D; Petit I
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2157-2162

  APR-246/PRIMA-1^MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

  Shen J; van den Bogaard EH; Kouwenhoven EN; Bykov VJN; Rinne T; Zhang Q; Tjabringa GS; Gilissen C; van Heeringen SJ; Schalkwijk J; van Bokhoven H; Wiman KG; Zhou H
• Journal article: ENDOCRINOLOGY. 2013;154(2):646-655

  Combined Inhibition of mTORC1 and mTORC2 Signaling Pathways Is a Promising Therapeutic Option in Inhibiting Pheochromocytoma Tumor Growth: In Vitro and In Vivo Studies in Female Athymic Nude Mice

  Giubellino A; Bullova P; Noelting S; Turkova H; Powers JF; Liu Q; Guichard S; Tischler AS; Grossman AB; Pacak K
• Article: CELL CYCLE. 2012;11(24):4563-4569

  p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP

  Madapura HS; Salamon D; Wiman KG; Lain S; Klein G; Klein E; Nagy N
• Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(29):3633-3639

  Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

  Lehmann S; Bykov VJN; Ali D; Andren O; Cherif H; Tidefelt U; Uggla B; Yachnin J; Juliusson G; Moshfegh A; Paul C; Wiman KG; Andersson P-O
• Article: CELL DEATH & DISEASE. 2012;3(4):e298

  Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth

  Vilborg A; Bersani C; Wickstrom M; Segerstrom L; Kogner P; Wiman KG
• Editorial: CELL DEATH AND DIFFERENTIATION. 2012;19(1):180-183

  Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop

  Blandino G; Deppert W; Hainaut P; Levine A; Lozano G; Olivier M; Rotter V; Wiman K; Oren M
• Article: EXPERIMENTAL ONCOLOGY. 2011;33(3):193-195

  Proteomic strategy for detection of circulating tumor cell surface antigens.

  Mints M; Souchelnytskyi S
• Review: CELL DEATH AND DIFFERENTIATION. 2011;18(9):1434-1440

  The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?

  Vilborg A; Bersani C; Wilhelm MT; Wiman KG
• Article: ENDOCRINE-RELATED CANCER. 2010;18(1):73-83

  Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

  Astuti D; Ricketts CJ; Chowdhury R; McDonough MA; Gentle D; Kirby G; Schlisio S; Kenchappa RS; Carter BD; Kaelin WGJ; Ratcliffe PJ; Schofield CJ; Latif F; Maher ER
• Article: ONCOGENE. 2010;29(49):6442-6451

  PRIMA-1^MET/APR-246 targets mutant forms of p53 family members p63 and p73

  Rokaeus N; Shen J; Eckhardt I; Bykov VJN; Wiman KG; Wilhelm MT
• Article: PLOS BIOLOGY. 2010;8(11):e1000521

  WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

  Mahmoudi S; Henriksson S; Weibrecht I; Smith S; Soderberg O; Stromblad S; Wiman KG; Farnebo M
• Conference publication: JOURNAL OF MEDICAL GENETICS. 2010;47:S118

  Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma

  Astuti D; Ricketts C; Chowdury R; McDonough MA; Gentle D; Kirby G; Schlisio S; Racliffe P; Schofield CJ; Latif F; Maher ER
• Article: CARCINOGENESIS. 2010;31(8):1475-1482

  Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein

  Gouas DA; Shi H; Hautefeuille AH; Ortiz-Cuaran SL; Legros PC; Szymanska KJ; Galy O; Egevad LA; Abedi-Ardekani B; Wiman KG; Hantz O; de Fromentel CC; Chemin IA; Hainaut PL
• Review: ONCOGENE. 2010;29(30):4245-4252

  Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

  Wiman KG
• Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2010;88(7):645-652

  Regulation of tumor suppressor p53 at the RNA level

  Vilborg A; Wilhelm MT; Wiman KG
• Article: CARCINOGENESIS. 2010;31(6):1045-1053

  Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells

  Karimi M; Conserva F; Mahmoudi S; Bergman J; Wiman KG; Bykov VJN
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):85-89

  The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

  Farnebo M; Bykov VJN; Wiman KG
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2010;36(6):1533-1539

  E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure

  Hovland S; Muller S; Skomedal H; Mints M; Bergstrom J; Wallin K-L; Karlsen F; Johansson B; Andersson S
• Article: ONCOGENE. 2010;29(9):1329-1338

  Mutant p53 reactivation by PRIMA-1^MET induces multiple signaling pathways converging on apoptosis

  Lambert JMR; Moshfegh A; Hainaut P; Wiman KG; Bykov VJN
• Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(10):4104-4112

  Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum

  Schlisio S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(37):15756-15761

  The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

  Vilborg A; Glahder JA; Wilhelm MT; Bersani C; Corcoran M; Mahmoudi S; Rosenstierne M; Grander D; Farnebo M; Norrild B; Wiman KG
• Article: LEUKEMIA & LYMPHOMA. 2009;50(9):1512-1518

  Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival

  Paul E; Uggla B; Deneberg S; Bengtzen S; Hermansson M; Dahlman I; Rosenquist R; Wiman KG; Nahi H
• Editorial: LANCET ONCOLOGY. 2009;10(9):913-919

  30 years and a long way into p53 research

  Hainaut P; Wiman KG
• Article: CELL CYCLE. 2009;8(16):2509-2517

  Mutant p53 rescue and modulation of p53 redox state

  Bykov VJN; Lambert JMR; Hainaut P; Wiman KG
• Article: CANCER CELL. 2009;15(5):376-388

  PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

  Lambert JMR; Gorzov P; Veprintsev DB; Soderqvist M; Segerback D; Bergman J; Fersht AR; Hainaut P; Wiman KG; Bykov VJN
• Review: CANCER LETTERS. 2009;276(1):1-7

  Regulation of p53R2 and its role as potential target for cancer therapy

  Wang X; Zhenchuk A; Wiman KG; Albertioni F
• Article: MOLECULAR CANCER. 2009;8:23

  PRIMA-1^MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein

  Stuber G; Flaberg E; Petranyi G; Otvos R; Rokaeus N; Kashuba E; Wiman KG; Klein G; Szekely L
• Article: MOLECULAR CELL. 2009;33(4):462-471

  Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

  Mahmoudi S; Henriksson S; Corcoran M; Mendez-Vidal C; Wiman KG; Farnebo M
• Article: ONCOGENE. 2008;27(35):4854-4859

  Proteomic identification of p53-dependent protein phosphorylation

  Rahman-Roblick R; Hellman U; Becker S; Bader FG; Auer G; Wiman KG; Roblick UJ
• Article: CARCINOGENESIS. 2008;29(7):1428-1434

  In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249

  Shi H; Lambert JMR; Hautefeuille A; Bykov VJN; Wiman KG; Hainaut P; de Fromentel CC
• Article: FEBS LETTERS. 2008;582(15):2173-2177

  The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA

  Prahl M; Vilborg A; Palmberg C; Joernvall H; Asker C; Wiman KG
• Article: MOLECULAR ONCOLOGY. 2008;2(1):70-80

  Mutant p53 targeting by the low molecular weight compound STIMA-1

  Zache N; Lambert JMR; Rokaeus N; Shen J; Hainaut P; Bergman J; Wiman KG; Bykou VN
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 2008;141(4):445-453

  Mutated and non-mutated TP53 as targets in the treatment of leukaemia

  Nahi H; Selivanova G; Lehmann S; Mollgard L; Bengtzen S; Concha H; Svensson A; Wiman KG; Merup M; Paul C
• Article: GENES & DEVELOPMENT. 2008;22(7):884-893

  The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

  Schlisio S; Kenchappa RS; Vredeveld LCW; George RE; Stewart R; Greulich H; Shahriari K; Nguyen NV; Pigny P; Dahia PL; Pomeroy SL; Maris JM; Look AT; Meyerson M; Peeper DS; Carter BD; Kaelin WGJ
• Article: NATURE CELL BIOLOGY. 2008;10(3):361-369

  VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

  Young AP; Schlisio S; Minamishima YA; Zhang Q; Li L; Grisanzio C; Signoretti S; Kaelin WGJ
• Article: RADIOTHERAPY AND ONCOLOGY. 2008;86(3):407-411

  PRIMA-1^met radiosensitizes prostate cancer cells independent of their MTp53-status

  Supiot S; Zhao H; Wiman K; Hill RP; Bristow RG
• Article: CELLULAR ONCOLOGY. 2008;30(5):411-418

  PRIMA-1^MET inhibits growth of mouse tumors carrying mutant p53

  Zache N; Lambert JMR; Wiman KG; Bykov VJN
• Article: MOLECULAR CELL. 2007;28(1):15-27

  pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-κB agonist Card9 by CK2

  Yang H; Minamishima YA; Yan Q; Schlisio S; Ebert BL; Zhang X; Zhang L; Kim WY; Olumi AF; Kaelin WGJ
• Review: CANCER CELL. 2007;12(4):303-312

  Shaping genetic alterations in human cancer: The p53 mutation paradigm

  Soussi T; Wiman KG
• Review: ONCOGENE. 2007;26(15):2243-2254

  Reactivation of mutant p53: molecular mechanisms and therapeutic potential

  Selivanova G; Wiman KG
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(13):5401-5406

  p53 targets identified by protein expression profiling

  Rahman-Roblick R; Roblick UJ; Hellman U; Conrotto P; Liu T; Becker S; Hirschberg D; Jornvall H; Auer G; Wiman KG
• Article: CELL DEATH AND DIFFERENTIATION. 2007;14(3):411-421

  Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis

  Liu T; Laurell C; Selivanova G; Lundeberg J; Nilsson P; Wiman KG
• Article: ONCOGENE. 2007;26(7):982-992

  PRIMA-1^MET induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins

  Rokaeus N; Klein G; Wiman KG; Szekely L; Mattsson K
• Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2007;97:321-338

  Restoration of wild-type p53 function in human tumors: Strategies for efficient cancer therapy

  Wiman KG
• Article: FEBS LETTERS. 2006;580(18):4401-4408

  The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs

  Vidal CM; Prahl M; Wiman KG
• Article: CELL DEATH AND DIFFERENTIATION. 2006;13(6):921-926

  Strategies for therapeutic targeting of the p53 pathway in cancer

  Wiman KG
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 2006;132(2):230-236

  PRIMA-1 induces apoptosis in acute myeloid leukaemia cells with p53 gene deletion

  Nahi H; Merup M; Lehmann S; Bengtzen S; Möllgård L; Selivanova G; Wiman KG; Paul C
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(34):30384-30391

  Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs

  Bykov VJN; Issaeva N; Zache N; Shilov A; Hultcrantz M; Bergman J; Selivanova G; Wiman KG
• Article: CANCER CELL. 2005;8(2):155-167

  Neuronal apoptosis linked to EgIN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer

  Lee S; Nakamura E; Yang HF; Wei WY; Linggi MS; Sajan MP; Farese RV; Freeman RS; Carter BD; Kaelin WGJ; Schlisio S
• Article: CANCER CELL. 2005;8(1):25-33

  The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

  Wei WY; Jin JP; Schlisio S; Harper JW; Kaelin WGJ
• Article: ONCOGENE. 2005;24(21):3484-3491

  PRIMA-1^MET synergizes with cisplatin to induce tumor cell apoptosis

  Bykov VJN; Zache N; Stridh H; Westman J; Bergman J; Selivanova G; Wiman KG
• Article: ONCOGENE. 2005;24(8):1320-1327

  hTERT antagonizes p53-induced apoptosis independently of telomerase activity

  Rahman R; Latonen L; Wiman KG
• Journal article: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2005;70(1):1

  CANCER-RELEVANT CULLIN-RING UBIQUITIN LIGASES

  Kaelin WG; Harper JW; Jin J; Kim W; Lee S; Reddy A; Safran M; Schlisio S; Wei W; Yang H; Zhang G-J
• Article: JOURNAL OF VISION. 2004;4(12):993-1005

  Perceptual learning in contrast discrimination: The effect of contrast uncertainty

  Adini Y; Wilkonsky A; Haspel R; Tsodyks M; Sagi D
• Article: GENES & DEVELOPMENT. 2004;18(23):2941-2951

  A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription

  Giangrande PH; Zhu WC; Schlisio S; Sun X; Mori S; Gaubatz S; Nevins JR
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 2004;127(3):285-291

  Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion

  Nahi H; Lehmann S; Mollgard L; Bengtzen S; Selivanova G; Wiman KG; Paul C; Merup M
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;24(6):1559-1564

  The p53-induced Wig-1 zinc finger protein is highly conserved from fish to man

  Hellborg F; Wiman KG
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(23):13303-13307

  Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

  Issaeva N; Friedler A; Bozko P; Wiman KG; Fersht AR; Selivanova G
• Article: EUROPEAN JOURNAL OF CANCER. 2003;39(13):1828-1834

  Small molecules that reactivate mutant p53

  Bykov VJN; Selivanova G; Wiman KG
• Article: ONCOGENE. 2003;22(32):4993-5005

  Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts

  Lindström MS; Wiman KG
• Article: ANNALS OF MEDICINE. 2003;35(7):458-465

  Novel cancer therapy by reactivation of the p53 apoptosis pathway

  Bykov VJN; Wiman KG
• Article: CARCINOGENESIS. 2002;23(12):2011-2018

  Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database

  Bykov VJN; Issaeva N; Selivanova G; Wiman KG
• Article: EMBO JOURNAL. 2002;21(21):5775-5786

  Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function

  Schlisio S; Halperin T; Vidal M; Nevins JR
• Article: SEMINARS IN CANCER BIOLOGY. 2002;12(5):381-387

  Role of genetic and epigenetic changes in Burkitt lymphoma

  Lindström MS; Wiman KG
• Article: INVESTIGATIONAL NEW DRUGS. 2002;20(3):253-259

  A novel high-through-put assay for screening of pro-apoptotic drugs

  Hägg M; Bivén K; Ueno T; Rydlander L; Björklund P; Wiman KG; Shoshan M; Linder S
• Article: FEBS LETTERS. 2002;524(1-3):69-72

  Identification of functional p53-binding motifs in the mouse wig-1 promoter

  Wilhelm MT; Méndez-Vidal C; Wiman KG
• Article: CANCER LETTERS. 2002;180(2):211-221

  A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF

  Hashemi J; Lindström MS; Asker C; Platz A; Hansson J; Wiman KG
• Article: NUCLEIC ACIDS RESEARCH. 2002;30(9):1991-1996

  The p53-induced mouse zinc finger protein wig-1 binds double-stranded RNA with high affinity

  Méndez-Vidal C; Wilhelm MT; Hellborg F; Qian W; Wiman KG
• Article: ONCOGENE. 2002;21(14):2119-2129

  Characterization of the p53-rescue drug CP-31398 in vitro and in living cells

  Rippin TM; Bykov VJN; Freund SMV; Selivanova G; Wiman KG; Fersht AR
• Article: NATURE MEDICINE. 2002;8(3):282-288

  Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

  Bykov VJN; Issaeva N; Shilov A; Hultcrantz M; Pugacheva E; Chumakov P; Bergman J; Wiman KG; Selivanova G
• Article: ONCOGENE. 2001;20(39):5466-5474

  Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein

  Hellborg F; Qian W; Mendez-Vidal C; Asker C; Kost-Alimova M; Wilhelm M; Imreh S; Wiman KG
• Article: ONCOGENE. 2001;20(17):2171-2177

  p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

  Lindström MS; Klangby U; Wiman KG
• Article: BRAIN PATHOLOGY. 2001;11(2):159-168

  p14^ARF Deletion and methylation in genetic pathways to glioblastomas

  Nakamura M; Watanabe T; Klangby U; Asker C; Wiman K; Yonekawa Y; Kleihues P; Ohgaki H
• Article: APOPTOSIS. 2001;6(1-2):133-137

  Inactivation of Myc-induced p53-dependent apoptosis in human tumors

  Henriksson M; Selivanova G; Lindström M; Wiman KG
• Article: ONCOGENE. 2000;19(45):5123-5133

  Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

  Xu DW; Wang Q; Gruber A; Björkholm M; Chen ZG; Zaid A; Selivanova G; Peterson C; Wiman KG; Pisa P
• Article: CANCER RESEARCH. 2000;60(18):5278-5283

  Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: Functional impact

  Girnita L; Girnita A; Brodin B; Xie YT; Nilsson G; Dricu A; Lundeberg J; Wejde J; Bartolazzi A; Wiman KG; Larsson O
• Article: EXPERIMENTAL CELL RESEARCH. 2000;256(2):400-410

  Immunolocalization of human p14^ARF to the granular component of the interphase nucleolus

  Lindström MS; Klangby U; Inoue R; Pisa P; Wiman KG; Asker CE
• Article: GENE. 2000;246(1-2):247-254

  p53 splice acceptor site mutation and increased HsRAD51 protein expression in Bloom's syndrome GM1492 fibroblasts

  Magnusson KP; Sandström M; Ståhlberg M; Larsson M; Flygare J; Hellgren D; Wiman KG; Ljungquist S
• Article: MOLECULAR CANCER RESEARCH. 2000;11(1):31-39

  Polyoma virus middle T and small t antigens cooperate to antagonize p53-induced cell cycle arrest and apoptosis

  Qian W; Wiman KG
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;265(1):1-6

  p53-induced apoptosis as a safeguard against cancer

  Asker C; Wiman KG; Selivanova G
• Article: ANTICANCER RESEARCH. 1999;19(4B):2939-2943

  Induction of the human ARF protein by serum starvation

  Inoue R; Asker C; Klangby U; Pisa P; Wiman KG
• Article: FEMS MICROBIOLOGY LETTERS. 1999;174(1):117-123

  The Bacillus subtilis regulator protein SpoIIE shares functional and structural similarities with eukaryotic protein phosphatases 2C

  Schroeter R; Schlisio S; Lucet I; Yudkin M; Borriss R
• Article: MOLECULAR AND CELLULAR BIOLOGY. 1999;19(5):3395-3402

  Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain

  Selivanova G; Ryabchenko L; Jansson E; Iotsova V; Wiman KG
• Review: MEDICAL ONCOLOGY. 1998;15(4):222-228

  New p53-based anti-cancer therapeutic strategies

  Wiman KG
• Article: ONCOGENE. 1998;17(18):2333-2337

  Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?

  Magnusson KP; Satalino R; Qian W; Klein G; Wiman KG
• Article: BLOOD. 1998;91(5):1680-1687

  p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma

  Klangby U; Okan I; Magnusson KP; Wendland M; Lind P; Wiman KG
• Article: SEMINARS IN CANCER BIOLOGY. 1998;8(5):369-378

  Reactivation of mutant p53: a new strategy for cancer therapy

  Selivanova G; Kawasaki T; Ryabchenko L; Wiman KG
• Article: ONCOGENE. 1997;15(22):2699-2704

  Wig-1, a new p53-induced gene encoding a zinc finger protein

  VarmehZiaie S; Okan I; Wang YS; Magnusson KP; Warthoe P; Strauss M; Wiman KG
• Review: EXPERIMENTAL CELL RESEARCH. 1997;237(1):14-18

  p53: Emergency brake and target for cancer therapy

  Wiman KG
• Review: LAKARTIDNINGEN. 1997;94(38):3268-3272

  [New transcription factor-based cancer therapy. Gene therapy, cell lysis, reactivation of p53 are the new approaches].

  Wiman KG
• Editorial: NATURE MEDICINE. 1997;3(8):839-840

  An old acquaintance resurfaces in human mesothelioma

  Wiman KG; Klein G
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1997;11(1):97-104

  p53 overexpression in normal and dysplastic tissues adjacent to p53 negative squamous cell carcinomas of the head and neck

  MunckWikland E; Blegen H; LewensohnFuchs I; Malec M; Auer G; Kuylenstierna R; Dalianis T; Wiman KG; Lindholm J
• Article: NATURE MEDICINE. 1997;3(6):632-638

  Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

  Selivanova G; Iotsova V; Okan I; Fritsche M; Strom M; Groner B; Grafstrom RC; Wiman KG
• Article: JOURNAL OF GENERAL VIROLOGY. 1997;78:893-903

  Role of p53 mutation in polyomavirus-induced tumorigenesis

  Wang Q; Kashuba E; Magnusson KP; Pokrovskaja K; Okan I; Klein G; Wiman KG
• Article: MOLECULAR CANCER RESEARCH. 1997;8(2):121-131

  Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice

  Shick L; Carman JH; Choi JK; Somasundaram K; Burrell M; Hill DE; Zeng YX; Wang YS; Wiman KG; Salhany K; Kadesch TR; Monroe JG; Donehower LA; ElDeiry WS
• Article: MOLECULAR CANCER RESEARCH. 1996;7(12):1723-1732

  Phenotype-related differences in the expression of D-type cyclins in human B cell-derived lines

  Pokrovskaja K; EhlinHenriksson B; Bartkova J; Bartek J; Scuderi R; Szekely L; Wiman KG; Klein G
• Article: NUCLEIC ACIDS RESEARCH. 1996;24(18):3560-3567

  The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region

  Selivanova G; Iotsova V; Kiseleva E; Strom M; Bakalkin G; Grafstrom RC; Wiman KG
• Article: INTERNATIONAL JOURNAL OF CANCER. 1996;67(1):106-112

  Wild-type p53-induced apoptosis in a Burkitt lymphoma cell line is inhibited by interferon gamma

  Sangfelt O; Einhorn S; Bjorklund AC; Wiman KG; Okan I; Grander D
• Article: ONCOGENE. 1996;12(12):2731-2735

  Abrogation of p53-induced G1 arrest by the HPV 16 E7 protein does not inhibit p53-induced apoptosis

  Wang YS; Okan I; Pokrovskaja K; Wiman KG
• Article: INTERNATIONAL JOURNAL OF CANCER. 1996;66(3):322-325

  Frequent expression of bcl-2 in renal-cell carcinomas carrying wild-type p53

  Tomita Y; Bilim V; Kawasaki T; Takahashi K; Okan I; Magnusson KP; Wiman KG
• Article: BLOOD. 1996;87(8):3360-3367

  Cyclin E overexpression in relapsed adult acute lymphoblastic leukemias of B-cell lineage

  Scuderi R; Palucka KA; Pokrovskaja K; Bjorkholm M; Wiman KG; Pisa P
• Article: CURRENT OPINION IN CELL BIOLOGY. 1995;7(6):835-842

  WHAT IS THE RESTRICTION POINT

  ZETTERBERG A; LARSSON O; WIMAN KG
• Article: ONCOGENE. 1995;11(10):1963-1969

  MOUSE AND RAT B-MYC SHARE AMINO-ACID-SEQUENCE HOMOLOGY WITH THE C-MYC TRANSCRIPTIONAL ACTIVATOR DOMAIN AND CONTAIN A B-MYC SPECIFIC CARBOXY-TERMINAL REGION

  ASKER CE; MAGNUSSON KP; PICCOLI SP; ANDERSSON K; KLEIN G; COLE MD; WIMAN KG
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;7(5):1123-1128

  IDENTIFICATION OF GENES OVEREXPRESSED IN THE SQCC/Y1 HUMAN BUCCAL CARCINOMA CELL-LINE USING THE DIFFERENTIAL DISPLAY METHOD

  SUNDQVIST K; IOTSOVA V; ZIAIE SV; WIMAN KG; HOOG C; GRAFSTROM RC
• Article: JOURNAL OF GENERAL VIROLOGY. 1995;76:2423-2432

  REVERSIBLE NUCLEOLAR TRANSLOCATION OF EPSTEIN-BARR VIRUS-ENCODED EBNA-5 AND HSP70 PROTEINS AFTER EXPOSURE TO HEAT-SHOCK OR CELL-DENSITY CONGESTION

  SZEKELY L; JIANG WQ; POKROVSKAJA K; WIMAN KG; KLEIN G; RINGERTZ N
• Article: CARCINOGENESIS. 1995;16(10):2515-2521

  CHARACTERIZATION OF HUMAN BUCCAL EPITHELIAL-CELLS TRANSFECTED WITH THE SIMIAN-VIRUS-40 T-ANTIGEN GENE

  KULKARNI PS; SUNDQVIST K; BETSHOLTZ C; HOGLUND P; WIMAN KG; ZHIVOTOVSKY B; BERTOLERO F; LIU Y; GRAFSTROM RC
• Article: ONCOGENE. 1995;11(6):1027-1031

  THE EBV-ENCODED LMP1 PROTEIN INHIBITS P53-TRIGGERED APOPTOSIS BUT NOT GROWTH ARREST

  OKAN I; WANG YS; CHEN F; HU LF; IMREH S; KLEIN G; WIMAN KG
• Other: GENE. 1995;162(2):231-234

  A SPLICE DONOR SITE MUTATION RESULTS IN THE INSERTION OF 5 EXTRA AMINO-ACIDS INTO P53 FROM SEWA MOUSE SARCOMA-CELLS

  MAGNUSSON KP; MINAROVITS J; KLEIN G; WIMAN KG
• Article: EUROPEAN JOURNAL OF CANCER PART B: ORAL ONCOLOGY. 1995;31B(5):328-332

  Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma

  Qian W; Hu LF; Chen F; Wang YS; Magnusson KP; Kashuba E; Klein G; Wiman KG
• Article: MOLECULAR CANCER RESEARCH. 1995;6(9):1071-1075

  BCL-2 INHIBITS WILD-TYPE P53-TRIGGERED APOPTOSIS BUT NOT G(1) CELL-CYCLE ARREST AND TRANSACTIVATION OF WAF1 AND BAX

  WANG YS; OKAN I; SZEKELY L; KLEIN G; WIMAN KG
• Article: INTERNATIONAL JOURNAL OF CANCER. 1995;61(5):683-691

  RB-RECONSTITUTED HUMAN RETINOBLASTOMA CELLS FORM RB-POSITIVE INTRAOCULAR AND INTRACEREBRAL BUT NOT SUBCUTANEOUS TUMORS IN SCID MICE

  SZEKELY L; WANG YS; KLEIN G; WIMAN KG
• Other: ONCOGENE. 1995;10(9):1869-1874

  RESTING B-CELLS, EBV-INFECTED B-BLASTS AND ESTABLISHED LYMPHOBLASTOID CELL-LINES DIFFER IN THEIR RB, P53 AND EBNA-5 EXPRESSION PATTERNS

  SZEKELY L; POKROVSKAJA K; JIANG WQ; SELIVANOVA G; LOWBEER M; RINGERTZ N; WIMAN KG; KLEIN G
• Article: NUCLEIC ACIDS RESEARCH. 1995;23(3):362-369

  P53 BINDS SINGLE-STRANDED-DNA ENDS THROUGH THE C-TERMINAL DOMAIN AND INTERNAL DNA SEGMENTS VIA THE MIDDLE DOMAIN

  BAKALKIN G; SELIVANOVA G; YAKOVLEVA T; KISELEVA E; KASHUBA E; MAGNUSSON KP; SZEKELY L; KLEIN G; TERENIUS L; WIMAN KG
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;6(1):27-29

  IN FRAME DELETION OF INTRON-7 IN THE P53 GENE IN A HUMAN TONSIL TUMOR

  MAGNUSSON KP; BERKE Z; MUNCKWIKLAND E; LEWENSOHNFUCHS I; KLEIN G; DALLIANIS T; WIMAN KG
• Review: MECHANISMS AND THERAPY OF LIVER CANCER. 1995;66:143-180

  P53 - A CELL-CYCLE REGULATOR ACTIVATED BY DNA-DAMAGE

  SELIVANOVA G; WIMAN KG
• Visa fler

Medarbetare och kontakt

Gruppledare

• 

  Susanne Schlisio

  Lektor | Docent

  Telefon +46852487117

  E-postadress susanne.schlisio@ki.se

  Plasticitet, tumörheterogenitet och metastasering vid neuroblastom och paragangliom

Alla medarbetare i gruppen

• 

  Petra Bullová

  Forskningsspecialist

  E-postadress petra.bullova@ki.se
• 

  Peng Cui

  Forskningsspecialist

  E-postadress peng.cui@ki.se
• Basile Cornelius Dalarun

  E-postadress basile.dalarun@ki.se
• Anastasiia Kuliagina

  Utbytestudent

  E-postadress anastasiia.kuliagina@ki.se
• 

  Wenyu Li

  Anknuten till Forskning

  E-postadress wenyu.li@ki.se
• Zinan Li

  Doktorand

  E-postadress zinan.li@ki.se
• Michael Mints

  Anknuten till Forskning | Docent

  E-postadress michael.mints@ki.se
• 

  Lidiya Mykhaylechko

  Postdoktorala Studier

  E-postadress lidiya.mykhaylechko@ki.se
• Valeriy Paramonov

  Postdoktor

  E-postadress valeriy.paramonov@ki.se
• Valentin Poltorachenko

  Anknuten till Forskning

  E-postadress valentin.poltorachenko@ki.se
• 

  Nicholas Smith

  Postdoktorala Studier

  E-postadress nicholas.smith@ki.se
• Jorrit Jilles Stada

  Doktorand

  E-postadress jorrit.stada@ki.se
• Amos Tuval Wilkonsky

  Postdoktor

  E-postadress amos.tuval@ki.se
• 

  Cheng Wei

  Postdoktorala Studier

  E-postadress cheng.wei@ki.se
• 

  Klas Wiman

  Professor, Senior

  E-postadress klas.wiman@ki.se
• 

  Jiacheng Joey Zhu

  Doktorand

  E-postadress jiacheng.zhu@ki.se

Team

Team Wiman

Foto: Gunnar Ask

Team Wiman

Basal och translationell cancerforskning med fokus på tumörsuppressorn p53 och ny p53-riktad cancerbehandling.