Postdoc Fellowships 2025 - Project 6
Project title: Exploring the Biological Pathways Linking Type 2 Diabetes and "Type 3 Diabetes"
Summary
Evidence has suggested that AD-type neurodegeneration may be mediated by insulin deficiency and resistance. Alzheimer’s disease (AD) has sometimes been conceptualized as "brain diabetes" or "type 3 diabetes" — given its shared molecular and biochemical features with diabetes. However, the genetic, metabolomic, and inflammatory profiles that underpin the prediction and progression of “type 3 diabetes” remain largely unexplored. The overarching goal of this 2-year project is to advance the understanding of the genetic, metabolic, and inflammatory pathways linking T2DM and AD based on data from large population-based cohort studies. Findings from this project lay the groundwork for developing integrated therapeutic strategies that simultaneously address the T2DM and AD.