Postdoc Fellowships 2025 - Project 7

Short running project title: Dietary Nitrate and non-heme iron in Diabetes

Project Title: Dietary Nitrate to Prevent Cardiovascular Disease in Diabetes

 

Summary

  • The signaling molecule nitric oxide (NO) plays important modulatory roles in cardiovascular and metabolic homeostasis.
  • Our research explores dietary inorganic nitrate and non-heme iron and their conversion to bioactive nitrogen oxides which enhance metabolic and cardiovascular functions.
  • A central part of the project is to use electron paramagnetic resonance (EPR) technology to measure nitrogen oxide radical species generated from nitrate and non-heme iron and evaluate their functional effects.
  • In a small clinical trial, we aim to investigate the effect of combined nitrate and non-heme iron supplementation in improving cardiovascular and metabolic health in Type 2 Diabetes (T2D) patients.

Read the complete project description

Main supervisor

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Co-supervisor

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Thomas Nyström

Professor/Senior Physician
Content reviewer:
Stefan Nobel
07-05-2025