Stefan Nobel

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About me

I have a research background with a PhD in medical sciences from Karolinska
Institutet followed by industrial postdoctoral experiences at Merck-Frosst,
Montreal and Pharmacia in Stockholm. I have also pursued a research and
teaching position at Stockholm University. I have recently worked as the
project manager for the strategic research area SRP Diabetes involving several industrial research collaborations [1].
[1] https://ki.se/en/srp-diabetes/strategic-research-programme-in-diabetes-srp-diabetes

Currently, I am working as a coordinator/advisor for industrial collaborations at the unit External Engagement Office at GVS, Karolinska Institutet.

Articles

Article: CHEMOSPHERE. 2020;239:124755
Tissue distribution of ¹⁴C-labelled perfluorooctanoic acid in adult mice after 1-5 days of dietary exposure to an experimental dose or a lower dose that resulted in blood levels similar to those detected in exposed humans
Bogdanska J; Borg D; Bergstrom U; Mellring M; Bergman A; DePierre J; Nobel S
Article: CHEMOSPHERE. 2014;98:28-36
Tissue distribution of ³⁵S-labelled perfluorobutanesulfonic acid in adult mice following dietary exposure for 1-5 days
Bogdanska J; Sundstrom M; Bergstrom U; Borg D; Abedi-Valugerdi M; Bergman A; DePierre J; Nobel S
Article: CHEMOSPHERE. 2012;87(8):865-871
Radiosynthesis of perfluorooctanesulfonate (PFOS) and perfluorobutanesulfonate (PFBS), including solubility, partition and adhesion studies.
Sundström M; Bogdanska J; Pham HV; Athanasios V; Nobel S; McAlees A; Eriksson J; DePierre JW; Bergman Å
Article: TOXICOLOGY. 2011;284(1-3):54-62
Tissue distribution of ³⁵S-labelled perfluorooctane sulfonate in adult mice after oral exposure to a low environmentally relevant dose or a high experimental dose
Bogdanska J; Borg D; Sundstrom M; Bergstrom U; Halldin K; Abedi-Valugerdi M; Bergman A; Nelson B; DePierre J; Nobel S
Article: REPRODUCTIVE TOXICOLOGY. 2010;30(4):558-565
Tissue distribution of ³⁵S-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 mice following late gestational exposure
Borg D; Bogdanska J; Sundstrom M; Nobel S; Hakansson H; Bergman A; DePierre JW; Halldin K; Bergstrom U
Article: PROTEIN EXPRESSION AND PURIFICATION. 2002;26(3):349-356
Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities.
Nobel CSI; Dunås F; Abrahmsén LB
Article: CYTOKINE. 2000;12(5):423-431
Expression of interleukin 1α and β, and interleukin 1 receptor antagonist mRNA in the rat central nervous system after peripheral administration of lipopolysaccharides
Eriksson C; Nobel S; Winblad B; Schultzberg M
Article: APOPTOSIS. 2000;5(2):153-163
Inhibition of Na+/K(+)-ATPase may be one mechanism contributing to potassium efflux and cell shrinkage in CD95-induced apoptosis.
Nobel CS; Aronson JK; van den Dobbelsteen DJ; Slater AF
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1998;353(1):73-84
Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species
Burkitt MJ; Bishop HS; Milne L; Tsang SY; Provan GJ; Nobel CSI; Orrenius S; Slater AFG
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1997;10(12):1319-1324
Disulfiram is a potent inhibitor of proteases of the caspase family
Nobel CSI; Kimland M; Nicholson DW; Orrenius S; Slater AFG
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1997;10(6):636-643
Mechanism of dithiocarbamate inhibition of apoptosis: Thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme
Stefan C; Nobel I; Burgess DH; Zhivotovsky B; Burkitt MJ; Orrenius S; Slater AFG
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(4):522s
REDOX MODULATION OF APOPTOTIC CELL DEATH
Orrenius S; Nobel S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(26):15420-15427
Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/AP0-1 antibody
vandenDobbelsteen DJ; Nobel CSI; Schlegel J; Cotgreave IA; Orrenius S; Slater AFG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(44):26202-26208
DITHIOCARBAMATES INDUCE APOPTOSIS IN THYMOCYTES BY RAISING THE INTRACELLULAR LEVEL OF REDOX-ACTIVE COPPER
NOBEL CSI; KIMLAND M; LIND B; ORRENIUS S; SLATER AFG
Article: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 1995;15(8):721-729
INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN AND MESSENGER-RNA IN THE RAT ADRENAL GLAND
SCHULTZBERG M; TINGSBORG S; NOBEL S; LUNDKVIST J; SVENSON S; SIMONCSITS A; BARTFAI T
Article: BIOCHEMICAL JOURNAL. 1995;306(Pt 3):771-778
NITRONE SPIN TRAPS AND A NITROXIDE ANTIOXIDANT INHIBIT A COMMON PATHWAY OF THYMOCYTE APOPTOSIS
SLATER AFG; NOBEL CSI; MAELLARO E; BUSTAMANTE J; KIMLAND M; ORRENIUS S
Article: NEUROIMMUNOMODULATION. 1995;2(2):61-73
INDUCTION OF INTERLEUKIN-1-BETA MESSENGER-RNA AND ENKEPHALIN MESSENGER-RNA IN THE RAT ADRENAL-GLAND BY LIPOPOLYSACCHARIDES STUDIED BY IN-SITU HYBRIDIZATION HISTOCHEMISTRY
NOBEL CSI; SCHULTZBERG M

All other publications

Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S147
Perinatal tissue distribution of perfluorooctane sulphonate (PFOS) in mice
Borg D; Bogdanska J; Sundstrom M; Nobel S; Hakansson H; Bergman A; DePierre J; Halldin K; Bergstrom U
Review: FEBS JOURNAL. 2001;268(15):4113-4125
Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones
Nobel S; Abrahmsen L; Oppermann U
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130(1-3):805-814
Novel enzymological profiles of human 11β-hydroxysteroid dehydrogenase type 1
Hult M; Nobel CSI; Abrahmsen L; Nicoll-Griffith DA; Jörnvall H; Oppermann UCT
Doctoral thesis: 1997
Thiol redox state in apoptosis : physiological and toxicant modulation
Nobel S
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(4):1032-1038
Dithiocarbamates and the redox regulation of cell death
Orrenius S; Nobel CSI; vandenDobbelsteen DJ; Burkitt MJ; Slater AFG
Review: CELL DEATH AND DIFFERENTIATION. 1996;3(1):57-62
Intracellular redox changes during apoptosis
Slater AFG; Stefan C; Nobel I; vandenDobbelsteen DJ; Orrenius S
Published conference paper: TOXICOLOGY LETTERS. 1995;82-3:149-153
Signalling mechanisms and oxidative stress in apoptosis
Slater AFG; Stefan C; Nobel I; vandenDobbelsteen DJ; Orrenius S
Published conference paper: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1995;1271(1):59-62
THE ROLE OF INTRACELLULAR OXIDANTS IN APOPTOSIS
SLATER AFG; NOBEL CSI; ORRENIUS S
Published conference paper: FUNDAMENTAL AND CLINICAL IMMUNOLOGY. 1995;3(2):69-70
REDOX STATE IMBALANCE IN THYMOCYTE APOPTOSIS - INHIBITION BY SPIN TRAP COMPOUNDS
MAELLARO E; SLATER AFG; NOBEL CSI; BUSTAMANTE J; KIMLAND M; ORRENIUS S
Conference publication: JOURNAL OF NEUROCHEMISTRY. 1993;61:S125
INDUCTION OF INTERLEUKIN-1 MESSENGER-RNA IN THE NERVOUS-SYSTEM
SCHULTZBERG M; NOBEL S

Employments

Project Coordinator, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2010-
Coordinator, Professional Services, Karolinska Institutet, 2025-2025

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