Christian Rück´s research group

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Anxiety, obsessive-compulsive disorder and genetics

Our group has two main areas of interest: obsessive-compulsive disorders (OCD, hoarding, body dysmorphic disorder (BDD)) and the genetics of anxiety disorders and in particular the genetics of response to cognitive behavior therapy (CBT).

OCD is a rather common and often disabling disorder characterized by intrusive thoughts (obsessions) and rituals (compulsions) that tend to ease the unpleasantness of the obsessive thoughts. We do also have an research interest in the so called obsessive-compulsive spectrum disorders such as hoarding and BDD. We are currently investigating the effects of internetbased CBT for OCD, a treatment form that could increase treatment access drastically, and our recently published pilot study was the first to show efficacy.

Other current or planned studies in the area include treatment studies of agomelatine and CBT for OCD+Aspergers syndrome, respectively. The neurocognitive aspects of OCD are studied in collaboration with Cambridge University. Hoarding is studied in a twin design.

The genetics of psychotherapy response is our other main focus. We are investigation how genetic variation can influence treatment outcome of CBT in depression and anxiety disorders.

Research Projects

  • The etiology, clinical presentation and treatment of hoarding disorder
  • Clinical trials of internet-based CBT in OCD
  • D-cycloserine vs placebo in OCD patients treated with CBT
  • Studies of genetic variation and CBT response in several disorders
  • A clinical trail of agomelatine in OCD
  • A national register study of capsulotomy in OCD
  • Compulsivity in OCD - a neurocognitive stud
  • CBT in patients with OCD and Asperger´s syndrome - a pilot study

Selected publications

Internet-based cognitive behavior therapy for obsessive compulsive disorder: a pilot study.
Andersson E, Ljótsson B, Hedman E, Kaldo V, Paxling B, Andersson G, et al
BMC Psychiatry 2011 Aug;11():125

Internet-based cognitive-behavioural therapy for severe health anxiety: randomised controlled trial.
Hedman E, Andersson G, Andersson E, Ljótsson B, Rück C, Asmundson G, et al
Br J Psychiatry 2011 Mar;198(3):230-6

[pubmed:21110842 ]

Capsulotomy for obsessive-compulsive disorder: long-term follow-up of 25 patients.
Rück C, Karlsson A, Steele J, Edman G, Meyerson B, Ericson K, et al
Arch. Gen. Psychiatry 2008 Aug;65(8):914-21

A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial.
Kakko J, Grönbladh L, Svanborg K, von Wachenfeldt J, Rück C, Rawlings B, et al
Am J Psychiatry 2007 May;164(5):797-803

Group members

Evelyn AnderssonAnknuten, Postdoc
Mia AsplundForskarstuderande
Julia BobergForskningsassistent, UF
Long ChenForskarstuderande
James CrowleyAnknuten
Hilda DanielsdottirForskningsassistent, UF
Diana DjurfeldtAnknuten
Jesper EnanderAnknuten, Postdoc
Torun ErikssonAnknuten
Oskar FlygareDoktorand, Forskarstuderande
Matthew HalvorsenAnknuten
Monica HellbergAnknuten
Volen IvanovAnknuten, Postdoc
Ekaterina IvanovaProjektsamordnare
Nils LindeforsAnknuten
Lina LundströmForskarstuderande
Lina MartinssonAnknuten
Manuel MattheisenAnknuten
Björn Owe-LarssonAnknuten
Christian RückForskargruppsledare, Lektor/överläkare
Susanna ÖstermanForskarstuderande