Postdoc Fellowships 2024 - Project 6
Short project title: Signal transducers regulating glucose transport in type 2 diabetes
Summary
The Integrative Physiology research group at the Department of Molecular Medicine and Surgery at Karolinska Institutet is seeking a highly motivated postdoctoral researcher to join the group of Professor Juleen R. Zierath. The research in the group is focused on translational studies on cellular and molecular mechanisms underlying insulin resistance and type 2 diabetes and the effects of physical activity on glucose and lipid metabolism in skeletal muscle.
This project is designed to test the role of signal transducers to improve glucose homeostasis by targeting skeletal muscle glucose transport. The candidate will explore the molecular signal transducers involved in the regulation of glucose transport to restore glucose uptake in skeletal muscle from people with type 2 diabetes. The team has identified several candidates that may play a direct role in glucose transport. The postdoctoral fellow will validate the role of novel signal transducers in the regulation of glucose transport and insulin sensitivity using knock-down and over-expression approaches in primary human skeletal muscle cells. Promising candidates will be further validated in in vivo models of type 2 diabetes through electroporation approaches.