Juleen Zierath

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About me

Research group leader for the group Integrative Physiology at the Department of Physiology and Pharmacology and at the Department of Molecular Medicine and Surgery.

Articles

Journal article: MOLECULAR METABOLISM. 2024;:102081
Exercise-Induced Methylation of the Serhl2 Promoter and Implication for Lipid Metabolism in Rat Skeletal Muscle.
Katayama M; Nomura K; Mudry JM; Chibalin AV; Krook A; Zierath JR
Journal article: JOURNAL OF SPORT AND HEALTH SCIENCE. 2024;:100980
Unlocking the secrets of exercise: A pathway to enhanced insulin sensitivity and skeletal muscle health in type 2 diabetes.
Zierath JR; Brady AJ; Macgregor KA; de Zevallos JO; Stocks B
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2024;158:155939
Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity
Jollet M; Tramontana F; Jiang LQ; Borg ML; Savikj M; Kuefner MS; Massart J; Barbosa TDC; Manneras-Holm L; Checa A; Pillon NJ; Chibalin AV; Bjornholm M; Zierath JR
Article: MOLECULAR METABOLISM. 2024;86:101968
Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism
Nomura K; Kinoshita S; Mizusaki N; Senga Y; Sasaki T; Kitamura T; Sakaue H; Emi A; Hosooka T; Matsuo M; Okamura H; Amo T; Wolf AM; Kamimura N; Ohta S; Itoh T; Hayashi Y; Kiyonari H; Krook A; Zierath JR; Kasuga M; Ogawa W
Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2024;15(4):1335-1347
Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6
Guimaraes DSPSF; Barrios NMF; de Oliveira AG; Rizo-Roca D; Jollet M; Smith JAB; Araujo TR; da Cruz MV; Marconato E; Hirabara SM; Vieira AS; Krook A; Zierath JR; Silveira LR
Article: NATURE METABOLISM. 2024;6(7):1329-1346
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Lecoutre S; Maqdasy S; Rizo-Roca D; Renzi G; Vlassakev I; Alaeddine LM; Higos R; Jalkanen J; Zhong J; Zareifi DS; Frendo-Cumbo S; Massier L; Hodek O; Juvany M; Moritz T; de Castro Barbosa T; Omar-Hmeadi M; Lopez-Yus M; Merabtene F; Abatan JB; Marcelin G; El Hachem E-J; Rouault C; Bergo MO; Petrus P; Zierath JR; Clement K; Krook A; Mejhert N; Ryden M
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2024;155:155834
Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice
Pendergrast LA; Ashcroft SP; Ehrlich AM; Treebak JT; Krook A; Dollet L; Zierath JR
Article: NATURE METABOLISM. 2024;6(6):1024-1035
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity
Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
Article: CELL REPORTS MEDICINE. 2024;5(1):101348
Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
Dollet L; Lundell LS; Chibalin AV; Pendergrast LA; Pillon NJ; Lansbury EL; Elmastas M; Frendo-Cumbo S; Jalkanen J; Barbosa TDC; Cervone DT; Caidahl K; Dmytriyeva O; Deshmukh AS; Barres R; Ryden M; Wallberg-Henriksson H; Zierath JR; Krook A
Article: CELL METABOLISM. 2023;35(10):1722-1735.e5
Seasonal light hours modulate peripheral clocks and energy metabolism in mice
Small L; Lundell LS; Iversen J; Ehrlich AM; Dall M; Basse AL; Dalbram E; Hansen AN; Treebak JT; Barres R; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14):e2220102120
metabolism in a tissue-specific manner
Basse AL; Nielsen KN; Karavaeva I; Ingerslev LR; Ma T; Havelund JF; Nielsen TS; Frost M; Peics J; Dalbram E; Dall M; Zierath JR; Barres R; Faergeman NJ; Treebak JT; Gerhart-Hines Z
Article: STAR PROTOCOLS. 2023;4(1):101985
Protocol to assess arteriovenous differences across the liver and hindlimb muscles in mice following treadmill exercise
Ashcroft SP; Jepsen SL; Ehrlich AM; Treebak JT; Holst JJ; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(8):e2218510120
Time of day determines postexercise metabolism in mouse adipose tissue
Pendergrast LA; Lundell LS; Ehrlich AM; Ashcroft SP; Schoenke M; Basse AL; Krook A; Treebak JT; Dollet L; Zierath JR
Article: GEROSCIENCE. 2023;45(1):569-589
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary
Erickson ML; Allen JM; Beavers DP; Collins LM; Davidson KW; Erickson KI; Esser KA; Hesselink MKC; Moreau KL; Laber EB; Peterson CA; Peterson CM; Reusch JE; Thyfault JP; Youngstedt SD; Zierath JR; Goodpaster BH; LeBrasseur NK; Buford TW; Sparks LM
Article: LIFE SCIENCE ALLIANCE. 2023;6(1):e202201598
Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers
Pillon NJ; Puig LS; Altintas A; Kamble PG; Casani-Galdon S; Gabriel BM; Barres R; Conesa A; Chibalin AV; Naslund E; Krook A; Zierath JR
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2022;135:155268
Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial
Savikj M; Stocks B; Sato S; Caidahl K; Krook A; Deshmukh AS; Zierath JR; Wallberg-Henriksson H
Article: SCIENCE ADVANCES. 2022;8(36):eabo3192
Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes
Pillon NJ; Smith JAB; Alm PS; Chibalin AV; Alhusen J; Arner E; Carninci P; Fritz T; Otten J; Olsson T; de ten Ryen SVD; Deldicque L; Caidahl K; Wallberg-Henriksson H; Krook A; Zierath JR
Article: NATURE GENETICS. 2022;54(9):1332-1344
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang Z; Emmerich A; Pillon NJ; Moore T; Hemerich D; Cornelis MC; Mazzaferro E; Broos S; Ahluwalia TS; Bartz TM; Bentley AR; Bielak LF; Chong M; Chu AY; Berry D; Dorajoo R; Dueker ND; Kasbohm E; Feenstra B; Feitosa MF; Gieger C; Graff M; Hall LM; Haller T; Hartwig FP; Hillis DA; Huikari V; Heard-Costa N; Holzapfel C; Jackson AU; Johansson A; Jorgensen AM; Kaakinen MA; Karlsson R; Kerr KF; Kim B; Koolhaas CM; Kutalik Z; Lagou V; Lind PA; Lorentzon M; Lyytikainen L-P; Mangino M; Metzendorf C; Monroe KR; Pacolet A; Perusse L; Pool R; Richmond RC; Rivera NV; Robiou-Du-Pont S; Schraut KE; Schulz C-A; Stringham HM; Tanaka T; Teumer A; Turman C; Van der Most PJ; Vanmunster M; Van Rooij FJA; Van Vliet-Ostaptchouk JV; Zhang X; Zhao J-H; Zhao W; Balkhiyarova Z; Balslev-Harder MN; Baumeister SE; Beilby J; Blangero J; Boomsma DI; Brage S; Braund PS; Brody JA; Bruinenberg M; Ekelund U; Liu C-T; Cole JW; Collins FS; Cupples LA; Esko T; Enroth S; Faul JD; Fernandez-Rhodes L; Fohner AE; Franco OH; Galesloot TE; Gordon SD; Grarup N; Hartman CA; Heiss G; Hui J; Illig T; Jago R; James A; Joshi PK; Jung T; Kahonen M; Kilpelainen TO; Koh W-P; Kolcic I; Kraft PP; Kuusisto J; Launer LJ; Li A; Linneberg A; Luan J; Vidal PM; Medland SE; Milaneschi Y; Moscati A; Musk B; Nelson CP; Nolte IM; Pedersen NL; Peters A; Peyser PA; Power C; Raitakari OT; Reedik M; Reiner AP; Ridker PM; Rudan I; Ryan K; Sarzynski MA; Scott LJ; Scott RA; Sidney S; Siggeirsdottir K; Smith AV; Smith JA; Sonestedt E; Strom M; Tai ES; Teo KK; Thorand B; Toenjes A; Tremblay A; Uitterlinden AG; Vangipurapu J; Van Schoor N; Volker U; Willemsen G; Williams K; Wong Q; Xu H; Young KL; Yuan JM; Zillikens MC; Zonderman AB; Ameur A; Bandinelli S; Bis JC; Boehnke M; Bouchard C; Chasman DI; Smith GD; De Geus EJC; Deldicque L; Dorr M; Evans MK; Ferrucci L; Fornage M; Fox C; Garland TJ; Gudnason V; Gyllensten U; Hansen T; Hayward C; Horta BL; Hypponen E; Jarvelin M-R; Johnson WC; Kardia SLR; Kiemeney LA; Laakso M; Langenberg C; Lehtimaki T; Le Marchand L; Magnusson PKE; Martin NG; Melbye M; Metspalu A; Meyre D; North KE; Ohlsson C; Oldehinkel AJ; Orho-Melander M; Pare G; Park T; Pedersen O; Penninx BWJH; Pers TH; Polasek O; Prokopenko I; Rotimi CN; Samani NJ; Sim X; Snieder H; Sorensen TIA; Spector TD; Timpson NJ; Van Dam RM; Van der Velde N; Van Duijn CM; Vollenweider P; Volzke H; Voortman T; Waeber G; Wareham NJ; Weir DR; Wichmann H-E; Wilson JF; Hevener AL; Krook A; Zierath JR; Thomis MAI; Loos RJF; Den Hoed M
Article: DIABETES. 2022;71(4):624-636
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Dollet L; Kuefner M; Caria E; Rizo-Roca D; Pendergrast L; Abdelmoez AM; Karlsson HKR; Bjornholm M; Dalbram E; Treebak JT; Harada J; Naslund E; Ryden M; Zierath JR; Pillon NJ; Krook A
Article: MOLECULAR & CELLULAR PROTEOMICS. 2022;21(3):100207
Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation
Stocks B; Gonzalez-Franquesa A; Borg ML; Bjornholm M; Niu L; Zierath JR; Deshmukh AS
Article: MOLECULAR METABOLISM. 2022;57:101440
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice
Small L; Ehrlich A; Iversen J; Ashcroft SP; Trost K; Moritz T; Hartmann B; Holst JJ; Treebak JT; Zierath JR; Barres R
Article: NATURE METABOLISM. 2022;4(2):190-202
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation
Maqdasy S; Lecoutre S; Renzi G; Frendo-Cumbo S; Rizo-Roca D; Moritz T; Juvany M; Hodek O; Gao H; Couchet M; Witting M; Kerr A; Bergo MO; Choudhury RP; Aouadi M; Zierath JR; Krook A; Mejhert N; Ryden M
Article: CELL METABOLISM. 2022;34(2):329-345.e8
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Sato S; Dyar KA; Treebak JT; Jepsen SL; Ehrlich AM; Ashcroft SP; Trost K; Kunzke T; Prade VM; Small L; Basse AL; Schonke M; Chen S; Samad M; Baldi P; Barres R; Walch A; Moritz T; Holst JJ; Lutter D; Zierath JR; Sassone-Corsi P
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2022;54(2):353-368
Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine
Kanaley JA; Colberg SR; Corcoran MH; Malin SK; Rodriguez NR; Crespo CJ; Kirwan JP; Zierath JR
Article: MOLECULAR METABOLISM. 2021;53:101290
Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health
Williams K; Carrasquilla GD; Ingerslev LR; Hochreuter MY; Hansson S; Pillon NJ; Donkin I; Versteyhe S; Zierath JR; Kilpelainen TO; Barres R
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2021;321(5):C770-C778
Discovery of thymosin β4 as a human exerkine and growth factor
Gonzalez-Franquesa A; Stocks B; Borg ML; Kuefner M; Dalbram E; Nielsen TS; Agrawal A; Pankratova S; Chibalin AV; Karlsson HKR; Gheibi S; Bjornholm M; Jorgensen NR; Clemmensen C; Hostrup M; Treebak JT; Krook A; Zierath JR; Deshmukh AS
Article: SCIENCE ADVANCES. 2021;7(43):eabi9654
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle
Gabriel BM; Smith JAB; Sardon-Puig L; Zhang X; Basse AL; Laker RC; Gao H; Liu Z; Dollet L; Treebak JT; Zorzano A; Huo Z; Ryden M; Lanner JT; Esser KA; Barres R; Pillon NJ; Krook A; Zierath JR
Article: NATURE COMMUNICATIONS. 2021;12(1):5948
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism
Massart J; Sjogren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barres R; O'Gorman DJ; Zierath JR; Krook A
Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2021;12(5):1232-1248
Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance
Borg ML; Massart J; De Castro Barbosa T; Archilla-Ortega A; Smith JAB; Lanner JT; Alsina-Fernandez J; Yaden B; Culver AE; Karlsson HKR; Brozinick JT; Zierath JR
Article: DIABETOLOGIA. 2021;64(9):2077-2091
Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes
Sjogren RJO; Rizo-Roca D; Chibalin AV; Chorell E; Furrer R; Katayama S; Harada J; Karlsson HKR; Handschin C; Moritz T; Krook A; Naslund E; Zierath JR
Article: PROTEOMES. 2021;9(3):37
Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome
Gonzalez-Franquesa A; Peijs L; Cervone DT; Kocana C; Zierath JR; Deshmukh AS
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2021;321(2):E203-E216
Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity
Smith JAB; Savikj M; Sethi P; Platt S; Gabriel BM; Hawley JA; Dunstan D; Krook A; Zierath JR; Naslund E
Article: CELL REPORTS. 2021;35(8):109180
Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity
Gonzalez-Franquesa A; Stocks B; Chubanava S; Hattel HB; Moreno-Justicia R; Peijs L; Treebak JT; Zierath JR; Deshmukh AS
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2021;118:154726
Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study
Karlsson HKR; Kasahara A; Ikeda M; Chibalin AV; Harada J; Ryden M; Krook A; Kato M; Kubota K; Zierath JR
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:619447
The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle
Maasar M-F; Turner DC; Gorski PP; Seaborne RA; Strauss JA; Shepherd SO; Cocks M; Pillon NJ; Zierath JR; Hulton AT; Drust B; Sharples AP
Article: JOURNAL OF PHYSIOLOGY. 2020;598(24):5739-5752
Contraction influencesPer2gene expression in skeletal muscle through a calcium-dependent pathway
Small L; Altintas A; Laker RC; Ehrlich A; Pattamaprapanont P; Villarroel J; Pillon NJ; Zierath JR; Barres R
Article: CELL METABOLISM. 2020;32(5):844-859.e5
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
Batista TM; Jayavelu AK; Albrechtsen NJW; Iovino S; Lebastchi J; Pan H; Dreyfuss JM; Krook A; Zierath JR; Mann M; Kahn CR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(38):23932-23941
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise
Brandao BB; Madsen S; Rabiee A; Oliverio M; Ruiz GP; Ferrucci DL; Branquinho JL; Razolli D; Pinto S; Nielsen TS; Festuccia WT; Martins AS; Guerra BA; Knittel TL; Sogaard D; Larsen S; Helge JW; Brandauer J; Velloso LA; Emanuelli B; Kornfeld J-W; Kahn CR; Vienberg SG; Zierath JR; Treebak JT; Mori MA
Article: NATURE COMMUNICATIONS. 2020;11(1):4643
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
Lundell LS; Parr EB; Devlin BL; Ingerslev LR; Altintas A; Sato S; Sassone-Corsi P; Barres R; Zierath JR; Hawley JA
Article: EPIGENOMICS. 2020;12(8):701-713
Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development
Altintas A; Laker RC; Garde C; Barres R; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2020;318(3):C615-C626
Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism
Abdelmoez AM; Puig LS; Smith JAB; Gabriel BM; Savikj M; Dollet L; Chibalin AV; Krook A; Zierath JR; Pillon NJ
Article: NATURE COMMUNICATIONS. 2020;11(1):470
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
Pillon NJ; Gabriel BM; Dollet L; Smith JAB; Puig LS; Botella J; Bishop DJ; Krook A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2020;318(1):E1-E10
Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression
Puig LS; Pillon NJ; Naslund E; Krook A; Zierath JR
Article: HEPATOLOGY RESEARCH. 2019;49(12):1451-1465
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism
Hochreuter MY; Altintas A; Garde C; Emanuelli B; Kahn CR; Zierath JR; Vienberg S; Barres R
Article: THE FASEB JOURNAL. 2019;33(9):10551-10562
Secreted protein acidic and rich in cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation
Aoi W; Hirano N; Lassiter DG; Bjornholm M; Chibalin AV; Sakuma K; Tanimura Y; Mizushima K; Takagi T; Naito Y; Zierath JR; Krook A
Article: CELL METABOLISM. 2019;30(1):92-110.e4
Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis
Sato S; Basse AL; Schonke M; Chen S; Samad M; Altintas A; Laker RC; Dalbram E; Barres R; Baldi P; Treebak JT; Zierath JR; Sassone-Corsi P
Article: DIABETES. 2019;68(7):1403-1414
Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice
Borg ML; Massart J; Schoenke M; Barbosa TDC; Guo L; Wade M; Alsina-Fernandez J; Miles R; Ryan A; Bauer S; Coskun T; O'Farrell E; Niemeier EM; Chibalin AV; Krook A; Karlsson HK; Brozinick JT; Zierath JR
Article: THE FASEB JOURNAL. 2019;33(5):6269-6280
Paternal high-fat diet transgenerationally impacts hepatic immunometabolism
Barbosa TDC; Alm PS; Krook A; Barres R; Zierath JR
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2019;126(4):993-1005
Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action
Dalbram E; Basse AL; Zierath JR; Treebak JT
Article: JOURNAL OF NUTRITION AND METABOLISM. 2019;2019:1840374-8
Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers
Lundstrom P; Caidahl K; Eriksson MJ; Fritz T; Krook A; Zierath JR; Rickenlund A
Article: DIABETES. 2019;68(3):515-526
Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle
Katayama M; Wiklander OPB; Fritz T; Caidahl K; El-Andaloussi S; Zierath JR; Krook A
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2019;316(2):E178-E185
Short-term low-calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults
Nylen C; Lundell LS; Massart J; Zierath JR; Naslund E
Article: MOLECULAR METABOLISM. 2019;20:79-88
Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle
Lundell LS; Massart J; Altintas A; Krook A; Zierath JR
Article: DIABETOLOGIA. 2019;62(2):233-237
Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial
Savikj M; Gabriel BM; Alm PS; Smith J; Caidahl K; Bjoernholm M; Fritz T; Krook A; Zierath JR; Wallberg-Henriksson H
Article: MOLECULAR METABOLISM. 2018;16:12-23
AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle
Lassiter DG; Sjogren RJO; Gabriel BM; Krook A; Zierath JR
Article: JOURNAL OF OBESITY. 2018;2018:7461903-8
Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus
Mashili FL; Ramaiya K; Lutale J; Njelekela M; Francis F; Zierath J; Krook A
Article: SCIENCE ADVANCES. 2018;4(8):eaar8590
Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
Cedernaes J; Schonke M; Westholm JO; Mi J; Chibalin A; Voisin S; Osler M; Vogel H; Hornaeus K; Dickson SL; Lind SB; Bergquist J; Schioth HB; Zierath JR; Benedict C
Article: JOURNAL OF LIPID RESEARCH. 2018;59(7):1148-1163
Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells
Pillon NJ; Frendo-Cumbo S; Jacobson MR; Liu Z; Milligan PL; Bui HH; Zierath JR; Bilan PJ; Brozinick JT; Klip A
Article: JOURNAL OF LIPID RESEARCH. 2018;59(7):1276-1282
Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism
Schoenke M; Massart J; Zierath JR
Article: ACTA PHYSIOLOGICA. 2018;223(3):e13051
Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury
Lundell LS; Savikj M; Kostovski E; Iversen PO; Zierath JR; Krook A; Chibalin AV; Widegren U
Article: PHYSIOLOGICAL REPORTS. 2018;6(12):e13739
Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals
Savikj M; Ruby MA; Kostovski E; Iversen PO; Zierath JR; Krook A; Widegren U
Article: PROTEOMICS. 2018;18(5-6):e1700375
Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition
Schonke M; Bjornholm M; Chibalin AV; Zierath JR; Deshmukh AS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(9):E2048-E2057
The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals
Younis S; Schonke M; Massart J; Hjortebjerg R; Sundstrom E; Gustafson U; Bjornholm M; Krook A; Frystyk J; Zierath JR; Andersson L
Article: JOURNAL OF LIPID RESEARCH. 2018;59(2):273-282
Diacylglycerol kinase. deficiency alters inflammation markers in adipose tissue in response to a high-fat diet
Nascimento EBM; Manneras-Holm L; Chibalin AV; Bjornholm M; Zierath JR
Article: DIABETOLOGIA. 2018;61(2):424-432
FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle
Lassiter DG; Nylen C; Sjogren RJO; Chibalin AV; Wallberg-Henriksson H; Naslund E; Krook A; Zierath JR
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1198
Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status
Basse AL; Dalbram E; Larsson L; Gerhart-Hines Z; Zierath JR; Treebak JT
Article: JOURNAL OF LIPID RESEARCH. 2017;58(12):2324-2333
DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism
Benziane B; Borg ML; Tom RZ; Riedl I; Massart J; Bjornholm M; Gilbert M; Chibalin AV; Zierath JR
Article: SCIENTIFIC REPORTS. 2017;7(1):15134
Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans
Laker RC; Garde C; Camera DM; Smiles WJ; Zierath JR; Hawley JA; Barres R
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2017;313(4):E483-E491
Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle
Ruby MA; Riedl I; Massart J; Ahlin M; Zierath JR
Article: JOURNAL OF PHYSIOLOGY. 2017;595(14):4611-4630
Early vertebrate origin and diversification of small transmembrane regulators of cellular ion transport
Pirkmajer S; Kirchner H; Lundell LS; Zelenin PV; Zierath JR; Makarova KS; Wolf YI; Chibalin AV
Article: DIABETES. 2017;66(7):1807-1818
Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle
Massart J; Sjogren RJO; Lundell LS; Mudry JM; Franck N; O'Gorman DJ; Egan B; Zierath JR; Krook A
Article: MOLECULAR METABOLISM. 2017;6(7):621-630
Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle
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Article: JOURNAL OF LIPID RESEARCH. 2017;58(5):907-915
Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice
Manneras-Holm L; Schonke M; Brozinick JT; Vetterli L; Bui H-H; Sanders P; Nascimento EBM; Bjornholm M; Chibalin AV; Zierath JR
Article: DIABETES. 2017;66(3):651-662
Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle
Mudry JM; Lassiter DG; Nylen C; Garcia-Calzon S; Naslund E; Krook A; Zierath JR
Article: DIABETES. 2017;66(3):598-612
Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK
Kjobsted R; Munk-Hansen N; Birk JB; Foretz M; Viollet B; Bjornholm M; Zierath JR; Treebak JT; Wojtaszewski JFP
Article: CELL REPORTS. 2017;18(3):636-646
Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance
Ruby MA; Massart J; Hunerdosse DM; Schonke M; Correia JC; Louie SM; Ruas JL; Naslund E; Nomura DK; Zierath JR
Article: PLOS MEDICINE. 2016;13(11):e1002179
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Lotta LA; Scott RA; Sharp SJ; Burgess S; Luan J; Tillin T; Schmidt AF; Imamura F; Stewart ID; Perry JRB; Marney L; Koulman A; Karoly ED; Forouhi NG; Sjogren RJO; Naslund E; Zierath JR; Krook A; Savage DB; Griffin JL; Chaturvedi N; Hingorani AD; Khaw K-T; Barroso I; McCarthy MI; O'Rahilly S; Wareham NJ; Langenberg C
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761
Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes
Mudry JM; Alm PS; Erhardt S; Goiny M; Fritz T; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2016;310(6):E461-E472
AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload
Riedl I; Osler ME; Bjornholm M; Egan B; Nader GA; Chibalin AV; Zierath JR
Article: MOLECULAR METABOLISM. 2016;5(3):171-183
Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
Kirchner H; Sinha I; Gao H; Ruby MA; Schonke M; Lindvall JM; Barres R; Krook A; Naslund E; Dahlman-Wright K; Zierath JR
Article: MOLECULAR METABOLISM. 2016;5(3):184-197
High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring
Barbosa TDC; Ingerslev LR; Alm PS; Versteyhe S; Massart J; Rasmussen M; Donkin I; Sjogren R; Mudry JM; Vetterli L; Gupta S; Krook A; Zierath JR; Barres R
Article: CELL METABOLISM. 2016;23(2):369-378
Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans
Donkin I; Versteyhe S; Ingerslev LR; Qian K; Mechta M; Nordkap L; Mortensen B; Appel EVR; Jorgensen N; Kristiansen VB; Hansen T; Workman CT; Zierath JR; Barres R
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2016;310(1):E51-E60
Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics
Jiang LQ; Barbosa TDC; Massart J; Deshmukh AS; Lofgren L; Duque-Guimaraes DE; Ozilgen A; Osler ME; Chibalin AV; Zierath JR
Article: MOLECULAR METABOLISM. 2015;4(12):891-902
Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Article: PHYSIOLOGICAL REPORTS. 2015;3(11):e12622
MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression.
Boon H; Sjögren RJO; Massart J; Egan B; Kostovski E; Iversen PO; Hjeltnes N; Chibalin AV; Widegren U; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2015;309(7):E679-E690
Skeletal muscle AMP-activated protein kinase γ1^H151R overexpression enhances whole body energy homeostasis and insulin sensitivity
Schonke M; Myers MGJ; Zierath JR; Bjornholm M
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(6):643-655
Effects of sleeping with reduced carbohydrate availability on acute training responses
Lane SC; Camera DM; Lassiter DG; Areta JL; Bird SR; Yeo WK; Jeacocke NA; Krook A; Zierath JR; Burke LM; Hawley JA
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2015;100(9):E1255-E1261
Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men
Cedernaes J; Osler ME; Voisin S; Broman J-E; Vogel H; Dickson SL; Zierath JR; Schioth HB; Benedict C
Article: DIABETES AND VASCULAR DISEASE RESEARCH. 2015;12(5):315-324
Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance
Ring M; Eriksson MJ; Fritz T; Nyberg G; Ostenson CG; Krook A; Zierath JR; Caidahl K
Article: DIABETES CARE. 2015;38(6):1154-1160
Changes in Gene Expression in Responders and Nonresponders to a Low-Intensity Walking Intervention
Osler ME; Fritz T; Caidahl K; Krook A; Zierath JR; Wallberg-Henriksson H
Article: DIABETES. 2015;64(6):2042-2055
Prior AICAR Stimulation Increases Insulin Sensitivity in Mouse Skeletal Muscle in an AMPK-Dependent Manner
Kjobsted R; Treebak JT; Fentz J; Lantier L; Viollet B; Birk JB; Schjerling P; Bjornholm M; Zierath JR; Wojtaszewski JFP
Article: PHYSIOLOGICAL REPORTS. 2015;3(4):e12372
mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.
Mannerås-Holm L; Kirchner H; Björnholm M; Chibalin AV; Zierath JR
Article: PHYSIOLOGICAL REPORTS. 2015;3(3):e12314
Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle.
Riedl I; Osler ME; Benziane B; Chibalin AV; Zierath JR
Article: PHYSIOLOGICAL GENOMICS. 2015;47(3):45-57
Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells
Sjogren RJO; Egan B; Katayama M; Zierath JR; Krook A
Article: DIABETES. 2015;64(2):360-369
Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation
Pirkmajer S; Kulkarni SS; Tom RZ; Ross FA; Hawley SA; Hardie DG; Zierath JR; Chibalin AV
Article: CELL METABOLISM. 2015;21(1):138-149
Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes
Multhaup ML; Seldin MM; Jaffe AE; Lei X; Kirchner H; Mondal P; Li Y; Rodriguez V; Drong A; Hussain M; Lindgren C; McCarthy M; Naslund E; Zierath JR; Wong GW; Feinberg AP
Article: HYPERTENSION RESEARCH. 2014;37(11):999-1007
Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques
Ring M; Eriksson MJ; Zierath JR; Caidahl K
Article: CELL. 2014;159(1):33-45
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: NATURE. 2014;512(7513):190-193
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
Moltke I; Grarup N; Jorgensen ME; Bjerregaard P; Treebak JT; Fumagalli M; Korneliussen TS; Andersen MA; Nielsen TS; Krarup NT; Gjesing AP; Zierath JR; Linneberg A; Wu X; Sun G; Jin X; Al-Aama J; Wang J; Borch-Johnsen K; Pedersen O; Nielsen R; Albrechtsen A; Hansen T
Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2014;10(4):671-678
Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass
Kirchner H; Nylen C; Laber S; Barres R; Yan J; Krook A; Zierath JR; Naslund E
Article: BMC RESEARCH NOTES. 2014;7:391
A simple and rapid method to characterize lipid fate in skeletal muscle.
Massart J; Zierath JR; Chibalin AV
Article: DIABETES. 2014;63(5):1560-1571
Effects of AMPK Activation on Insulin Sensitivity and Metabolism in Leptin-Deficient ob/ob Mice
Tom RZ; Garcia-Roves PM; Sjogren RJO; Jiang LQ; Holmstrom MH; Deshmukh AS; Vieira E; Chibalin AV; Bjornholm M; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1359-E1366
Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7
Jiang LQ; Franck N; Egan B; Sjogren RJO; Katayama M; Duque-Guimaraes D; Arner P; Zierath JR; Krook A
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1408-E1414
Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle
Nascimento EBM; Osler ME; Zierath JR
Article: JOURNAL OF PHYSIOLOGY. 2013;591(20):5207-5220
AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle
Brandauer J; Vienberg SG; Andersen MA; Ringholm S; Risis S; Larsen PS; Kristensen JM; Frosig C; Leick L; Fentz J; Jorgensen S; Kiens B; Wojtaszewski JFP; Richter EA; Zierath JR; Goodyear LJ; Pilegaard H; Treebak JT
Article: ENDOCRINOLOGY. 2013;154(10):3502-3514
Conventional Knockout of Tbc1d1 in Mice Impairs Insulin- and AICAR-Stimulated Glucose Uptake in Skeletal Muscle
Dokas J; Chadt A; Nolden T; Himmelbauer H; Zierath JR; Joost H-G; Al-Hasani H
Article: JOURNAL OF PHYSIOLOGY. 2013;591(18):4637-4653
Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training
Russell AP; Lamon S; Boon H; Wada S; Gueller I; Brown EL; Chibalin AV; Zierath JR; Snow RJ; Stepto N; Wadley GD; Akimoto T
Article: THE FASEB JOURNAL. 2013;27(9):3660-3671
Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet
Cansby E; Amrutkar M; Holm LM; Nerstedt A; Reyahi A; Stenfeldt E; Boren J; Carlsson P; Smith U; Zierath JR; Mahlapuu M
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2013;62(9):1258-1267
Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice
Holmstrom MH; Tom RZ; Bjornholm M; Garcia-Roves PM; Zierath JR
Article: PHYSIOLOGICAL GENOMICS. 2013;45(9):367-376
Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight
Ka S; Markljung E; Ring H; Albert FW; Harun-Or-Rashid M; Wahlberg P; Garcia-Roves PM; Zierath JR; Denbow DM; Paabo S; Siegel PB; Andersson L; Hallbook F
Article: CELL REPORTS. 2013;3(4):1020-1027
Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation
Barres R; Kirchner H; Rasmussen M; Yan J; Kantor FR; Krook A; Naslund E; Zierath JR
Article: DIABETES. 2013;62(2):355-361
Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients
Jiang LQ; Duque-Guimaraes DE; Machado UF; Zierath JR; Krook A
Article: DIABETES. 2013;62(2):457-465
Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes
Mashili F; Chibalin AV; Krook A; Zierath JR
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2013;62(1):79-89
L-Arginine enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway
Barbosa TDC; Jiang LQ; Zierath JR; Nunes MT
Article: PLOS ONE. 2013;8(9):e74098
Time Course Analysis Reveals Gene-Specific Transcript and Protein Kinetics of Adaptation to Short-Term Aerobic Exercise Training in Human Skeletal Muscle
Egan B; O'Connor PL; Zierath JR; O'Gorman DJ
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2013;29(1):25-32
Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance
Fritz T; Caidahl K; Krook A; Lundstrom P; Mashili F; Osler M; Szekeres FLM; Ostenson CG; Wandell P; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2012;303(4):E524-E533
The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism
Szekeres F; Chadt A; Tom RZ; Deshmukh AS; Chibalin AV; Bjornholm M; Al-Hasani H; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(28):23451-23463
Activation of AMP-activated Protein Kinase Stimulates Na⁺,K⁺-ATPase Activity in Skeletal Muscle Cells
Benziane B; Bjornholm M; Pirkmajer S; Austin RL; Kotova O; Viollet B; Zierath JR; Chibalin AV
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2012;302(6):E731-E739
Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes
Holmstrom MH; Iglesias-Gutierrez E; Zierath JR; Garcia-Roves PM
Article: CELL METABOLISM. 2012;15(3):405-411
Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle
Barres R; Yan J; Egan B; Treebak JT; Rasmussen M; Fritz T; Caidahl K; Krook A; O'Gorman DJ; Zierath JR
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2012;61(2):175-185
Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus
Kulkarni SS; Salehzadeh F; Fritz T; Zierath JR; Krook A; Osler ME
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(18):2555-2561
Evidence for non-CpG methylation in mammals
Yan J; Zierath JR; Barres R
Article: DIABETIC MEDICINE. 2011;28(11):1362-1372
Effects of Nordic walking on health-related quality of life in overweight individuals with Type 2 diabetes mellitus, impaired or normal glucose tolerance
Fritz T; Caidahl K; Osler M; Oestenson CG; Zierath JR; Waendell P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(40):34567-34574
Suppression of 5′-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle
Kulkarni SS; Karlsson HKR; Szekeres F; Chibalin AV; Krook A; Zierath JR
Article: DIABETOLOGIA. 2011;54(4):795-802
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.
Hribal ML; Presta I; Procopio T; Marini MA; Stančáková A; Kuusisto J; Andreozzi F; Hammarstedt A; Jansson P-A; Grarup N; Hansen T; Walker M; Stefan N; Fritsche A; Häring HU; Pedersen O; Smith U; Laakso M; Sesti G; EUGENE2 Consortium
Article: PROTEOMICS. 2011;11(8):1413-1428
2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training
Egan B; Dowling P; O'Connor PL; Henry M; Meleady P; Zierath JR; O'Gorman DJ
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2011;27(3):286-297
Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
Mashili FL; Austin RL; Deshmukh AS; Fritz T; Caidahl K; Bergdahl K; Zierath JR; Chibalin AV; Moller DE; Kharitonenkov A; Krook A
Article: THROMBOSIS AND HAEMOSTASIS. 2011;105(1):122-130
Strenuous physical exercise adversely affects monocyte chemotaxis
Czepluch FS; Barres R; Caidahl K; Olieslagers S; Krook A; Rickenlund A; Zierath JR; Waltenberger J
Article: DIABETOLOGIA. 2011;54(1):157-167
Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training
Vind BF; Pehmoller C; Treebak JT; Birk JB; Hey-Mogensen M; Beck-Nielsen H; Zierath JR; Wojtaszewski JFP; Hojlund K
Article: JOURNAL OF BIOLOGICAL SYSTEMS. 2010;18(3):687-707
VALIDATION OF THE IN VITRO INCUBATION OF EXTENSOR DIGITORUM LONGUS MUSCLE FROM MICE WITH A MATHEMATICAL MODEL
Sogaard P; Harlen M; Long YC; Szekeres F; Barnes BR; Chibalin AV; Zierath JR
Article: MOLECULAR IMMUNOLOGY. 2010;47(14):2388-2396
The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells
Feng X; Yan J; Wang Y; Zierath JR; Nordenskjold M; Henter J-I; Fadeel B; Zheng C
Article: DIABETOLOGIA. 2010;53(6):1142-1150
Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)α1-specific activity and glucose transport in human skeletal muscle
Deshmukh AS; Long YC; Barbosa TDC; Karlsson HKR; Glund S; Zavadoski WJ; Gibbs EM; Koistinen HA; Wallberg-Henriksson H; Zierath JR
Article: JOURNAL OF PHYSIOLOGY. 2010;588(10):1779-1790
Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor. coactivator-1α mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle
Egan B; Carson BP; Garcia-Roves PM; Chibalin AV; Sarsfield FM; Barron N; McCaffrey N; Moyna NM; Zierath JR; O'Gorman DJ
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2010;109(5):943-949
Spatial Insulin Signalling in Isolated Skeletal Muscle Preparations
Sogaard P; Szekeres F; Garcia-Roves PM; Larsson D; Chibalin AV; Zierath JR
Article: CELL METABOLISM. 2010;11(3):213-219
Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
Canto C; Jiang LQ; Deshmukh AS; Mataki C; Coste A; Lagouge M; Zierath JR; Auwerx J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2010;298(1):E8-E16
Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity
Jiang LQ; Garcia-Roves PM; Barbosa TDC; Zierath JR
Article: PLOS BIOLOGY. 2009;7(12):e1000256
ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth
Markljung E; Jiang L; Jaffe JD; Mikkelsen TS; Wallerman O; Larhammar M; Zhang X; Wang L; Saenz-Vash V; Gnirke A; Lindroth AM; Barres R; Yan J; Stromberg S; De S; Ponten F; Lander ES; Carr SA; Zierath JR; Kullander K; Wadelius C; Lindblad-Toh K; Andersson G; Hjalm G; Andersson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2009;297(6):C1554-C1566
AMP-activated protein kinase activator A-769662 is an inhibitor of the Na⁺-K⁺-ATPase
Benziane B; Bjornholm M; Lantier L; Viollet B; Zierath JR; Chibalin AV
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2009;297(6):E1388-E1394
Role of the AMPKγ3 isoform inhypoxia-stimulated glucose transport in glycolytic skeletal muscle
Deshmukh AS; Glund S; Tom RZ; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(44):30016-30023
Insulin-stimulated Phosphorylation of the Rab GTPase-activating Protein TBC1D1 Regulates GLUT4 Translocation
Peck GR; Chavez JA; Roach WG; Budnik BA; Lane WS; Karlsson HKR; Zierath JR; Lienhard GE
Article: DIABETOLOGIA. 2009;52(10):2182-2189
Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes
Rune A; Osler ME; Fritz T; Zierath JR
Article: CELL METABOLISM. 2009;10(3):189-198
Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density
Barres R; Osler ME; Yan J; Rune A; Fritz T; Caidahl K; Krook A; Zierath JR
Article: DIABETOLOGIA. 2009;52(5):891-900
Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle
Treebak JT; Frosig C; Pehmoller C; Chen S; Maarbjerg SJ; Brandt N; MacKintosh C; Zierath JR; Hardie DG; Kiens B; Richter EA; Pilegaard H; Wojtaszewski JFP
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2009;296(5):E969-E972
Hunting for the SNARK in metabolic disease
Egan B; Zierath JR
Article: CIRCULATION RESEARCH. 2009;104(8):961-968
T Cell-Mediated Inflammation in Adipose Tissue Does Not Cause Insulin Resistance in Hyperlipidemic Mice
Sultan A; Strodthoff D; Robertson A-K; Paulsson-Berne G; Fauconnier J; Parini P; Ryden M; Thierry-Mieg N; Johansson ME; Chibalin AV; Zierath JR; Arner P; Hansson GK
Article: DIABETES. 2009;58(4):847-854
Kinetics of GLUT4 Trafficking in Rat and Human Skeletal Muscle
Karlsson HKR; Chibalin AV; Koistinen HA; Yang J; Koumanov F; Wallberg-Henriksson H; Zierath JR; Holman GD
Article: ENDOCRINOLOGY. 2009;150(2):600-606
Role of Adenosine 5′-Monophosphate-Activated Protein Kinase in Interleukin-6 Release from Isolated Mouse Skeletal Muscle
Glund S; Treebak JT; Long YC; Barres R; Viollet B; Wojtaszewski JF; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(51):35724-35734
Gain-of-function R225Q Mutation in AMP-activated Protein Kinase γ3 Subunit Increases Mitochondrial Biogenesis in Glycolytic Skeletal Muscle
Garcia-Roves PM; Osler ME; Holmstrom MH; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2008;295(6):E1427-E1438
Divergent cell signaling after short-term intensified endurance training in human skeletal muscle
Benziane B; Burton TJ; Scanlan B; Galuska D; Canny BJ; Chibalin AV; Zierath JR; Stepto NK
Article: JOURNAL OF ENDOCRINOLOGY. 2008;199(2):X1
The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms.
Lundholm L; Bryzgalova G; Gao H; Portwood N; Fält S; Berndt KD; Dicker A; Galuska D; Zierath JR; Gustafsson J-Å; Efendic S; Dahlman-Wright K; Khan A
Article: NATURE GENETICS. 2008;40(11):1354-1359
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
Chadt A; Leicht K; Deshmukh A; Jiang LQ; Scherneck S; Bernhardt U; Dreja T; Vogel H; Schmolz K; Kluge R; Zierath JR; Hultschig C; Hoeben RC; Schuermann A; Joost H-G; Al-Hasani H
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2008;295(5):E1032-E1037
Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle
Vieira E; Nilsson EC; Nerstedt A; Ormestad M; Long YC; Garcia-Roves PM; Zierath JR; Mahlapuu M
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2008;24(7):554-562
Globular adiponectin stimulates glucose transport in type 2 diabetic muscle
Kuoppamaa H; Skrobuk P; Sihvo M; Hiukka A; Chibalin AV; Zierath JR; Koistinen HA
Article: DIABETES. 2008;57(8):2066-2073
SiRNA-mediated reduction of inhibitor of nuclear factor-κB kinase prevents tumor necrosis factor-α-induced insulin resistance in human skeletal muscle
Austin RL; Rune A; Bouzakri K; Zierath JR; Krook A
Article: CELL METABOLISM. 2008;7(6):545-554
Glutamate is a positive autocrine signal for glucagon release
Cabrera O; Jacques-Silva MC; Speier S; Yang S-N; Kohler M; Fachado A; Vieira E; Zierath JR; Kibbey R; Berman DM; Kenyon NS; Ricordi C; Caicedo A; Berggren P-O
Article: DIABETES. 2008;57(6):1508-1516
Malonyl coenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle
Bouzakri K; Austin R; Rune A; Lassman ME; Garcia-Roves PM; Berger JP; Krook A; Chibalin AV; Zhang BB; Zierath JR
Article: MOLECULAR ENDOCRINOLOGY. 2008;22(5):1105-1112
Role of adenosine 5′-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling
Deshmukh AS; Treebak JT; Long YC; Viollet B; Wojtaszewski JFP; Zierath JR
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2008;93(5):1924-1930
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.
Stancáková A; Pihlajamäki J; Kuusisto J; Stefan N; Fritsche A; Häring H; Andreozzi F; Succurro E; Sesti G; Boesgaard TW; Hansen T; Pedersen O; Jansson PA; Hammarstedt A; Smith U; Laakso M; EUGENE2 Consortium
Article: DIABETOLOGIA. 2008;51(3):502-511
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.
Laakso M; Zilinskaite J; Hansen T; Boesgaard TW; Vänttinen M; Stancáková A; Jansson P-A; Pellmé F; Holst JJ; Kuulasmaa T; Hribal ML; Sesti G; Stefan N; Fritsche A; Häring H; Pedersen O; Smith U; EUGENE2 Consortium
Article: CELL. 2008;132(3):375-386
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
Chibalin AV; Leng Y; Vieira E; Krook A; Bjoernholm M; Long YC; Kotova O; Zhong Z; Sakane F; Steiler T; Nylen C; Wang J; Laakso M; Topham MK; Gilbert M; Wallberg-Henriksson H; Zierath JR
Article: EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM. 2007;2(4):477-485
Skeletal muscle AMP kinase as a target to prevent pathogenesis of Type 2 diabetes.
Krook A; Long YC; Zierath JR
Article: DIABETES. 2007;56(6):1630-1637
Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle
Glund S; Deshmukh A; Long YC; Moller T; Koistinen HA; Caidahl K; Zierath JR; Krook A
Article: PLOS MEDICINE. 2007;4(5):e158-879
TXNIP regulates peripheral glucose metabolism in humans
Parikh H; Carlsson E; Chutkow WA; Johansson LE; Storgaard H; Poulsen P; Saxena R; Ladd C; Schulze PC; Mazzini MJ; Jensen CB; Krook A; Bjornholm M; Tornqvist H; Zierath JR; Ridderstrale M; Altshuler D; Lee RT; Vaag A; Groop LC; Mootha VK
Article: DIABETOLOGIA. 2007;50(5):1048-1057
Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor α/γ agonist on glucose uptake
Hu X; Feng Y; Liu X; Zhao X-F; Yu J-H; Yang Y-S; Sydow-Backman M; Horling J; Zierath JR; Leng Y
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(11):7783-7789
MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-α-induced insulin resistance
Bouzakri K; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(3):1607-1614
Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression
Long YC; Glund S; Garcia-Roves PM; Zierath JR
Article: DIABETOLOGIA. 2006;49(12):2983-2992
Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes
O'Gorman DJ; Karlsson HKR; McQuaid S; Yousif O; Rahman Y; Gasparro D; Glund S; Chibalin AV; Zierath JR; Nolan JJ
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2006;22(6):492-498
Low-intensity exercise increases sketelal muscle protein expression of PPARδ and UCP3 in type 2 diabetic patients
Fritz T; Kramer DK; Karlsson HKR; Galuska D; Engfeldt P; Zierath JR; Krook A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2006;63(19-20):2405-2414
Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity
Wang J; Shafqat J; Hall K; Stahlberg M; Wivall-Helleryd I-L; Bouzakri K; Zierath JR; Brismar K; Jornvall H; Lewitt MS
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(31):21690-21697
Neuregulins mediate calcium-induced glucose transport during muscle contraction
Canto C; Chibalin AV; Barnes BR; Glund S; Suarez E; Ryder JW; Palacin M; Zierath JR; Zorzano A; Guma A
Article: CELL METABOLISM. 2006;4(1):89-96
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
Bouzakri K; Zachrisson A; Al-Khalili L; Zhang BB; Koistinen HA; Krook A; Zierath JR
Article: DIABETES. 2006;55(7):2051-2058
AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits
Treebak JT; Glund S; Deshmukh A; Klein DK; Long YC; Jensen TE; Jorgensen SB; Viollet B; Andersson L; Neumann D; Wallimann T; Richter EA; Chibalin AV; Zierath JR; Wojtaszewski JFP
Article: DIABETES. 2006;55(6):1776-1782
Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle
Deshmukh A; Coffey VG; Zhong Z; Chibalin AV; Hawley JA; Zierath JR
Article: DIABETES. 2006;55(5):1283-1288
Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients
Karlsson HKR; Ahlsen M; Zierath JR; Wallberg-Henriksson H; Koistinen HA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(11):7244-7252
Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase γ3 R225Q transgenic versus knock-out mice
Nilsson EC; Long YC; Martinsson S; Glund S; Garcia-Roves P; Svensson LT; Andersson L; Zierath JR; Mahlapuu M
Article: DIABETES. 2006;55(3):785-791
IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients
Bouzakri K; Karlsson HKR; Vestergaard H; Madsbad S; Christiansen E; Zierath JR
Article: DIABETOLOGIA. 2006;49(3):588-597
Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice:: insulin sensitivity in the liver
Bryzgalova G; Gao H; Ahren B; Zierath JR; Galuska D; Steiler TL; Dahlman-Wright K; Nilsson S; Gustafsson J; Efendic S; Khan A
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2006;17(1):45-52
Differential expression of peroxisomal proliferator activated receptors α and δ in skeletal muscle in response to changes in diet and exercise
Kannisto K; Chibalin A; Glinghammar B; Zierath JR; Hamsten A; Ehrenborg E
Article: THE FASEB JOURNAL. 2006;19(13):190-192
Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
Coffey VG; Zhong ZH; Shield A; Canny BJ; Chibalin AV; Zierath JR; Hawley JA
Article: DIABETES. 2005;54(12):3484-3489
Changes in exercise-induced gene expression in 5′-AMP-activated protein kinase γ3-null and γ3 R225Q transgenic mice
Barnes BR; Long YC; Steiler TL; Leng Y; Galuska D; Wojtaszewski JFP; Andersson L; Zierath JR
Article: DIABETOLOGIA. 2005;48(11):2354-2364
Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle
Long YC; Barnes BR; Mahlapuu M; Steiler TL; Martinsson S; Leng Y; Wallberg-Henriksson H; Andersson L; Zierath JR
Article: DIABETES. 2005;54(10):2939-2945
Tumor necrosis factor-α induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation
Plomgaard P; Bouzakri K; Krogh-Madsen R; Mittendorfer B; Zierath JR; Pedersen BK
Article: DIABETES. 2005;54(9):2685-2693
Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle -: Effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor α, and interleukin-6
Bach D; Naon D; Pich S; Soriano FX; Vega N; Rieusset J; Laville M; Guillet C; Boirie Y; Wallberg-Henriksson H; Manco M; Calvani M; Castagneto M; Palacín M; Mingrone G; Zierath JR; Vidal H; Zorzano A
Article: JOURNAL OF PHYSIOLOGY. 2005;567(2):379-386
Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle
Ryder JW; Long YC; Nilsson E; Mahlapuu M; Zierath JR
Article: DIABETES. 2005;54(6):1692-1697
Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects
Karlsson HKR; Zierath JR; Kane S; Krook A; Lienhard GE; Wallberg-Henriksson H
Article: DIABETOLOGIA. 2005;48(6):1173-1179
Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1
Al-Khalili L; Forsgren M; Kannisto K; Zierath J; Lönnqvist F; Krook A
Article: DIABETES. 2005;54(5):1459-1467
Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes -: A randomized controlled study
Karlsson HKR; Hällsten K; Björnholm M; Tsuchida H; Chibalin AV; Virtanen KA; Heinonen OJ; Lönnqvist F; Nuutila P; Zierath JR
Article: THE FASEB JOURNAL. 2005;19(7):773-779
5′-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics
Barnes BR; Glnnd S; Long YC; Hjälm G; Andersson L; Zierath JR
Article: DIABETES. 2005;54(4):1157-1163
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor δ
Krämer DK; Al-Khalili L; Perrini S; Skogsberg J; Wretenberg P; Kannisto K; Wallberg-Henriksson H; Ehrenborg E; Zierath JR; Krook A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(37):38441-38447
The 5′-AMP-activated protein kinase γ3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle
Barnes BR; Marklund S; Steiler TL; Walter M; Hjälm G; Amarger V; Mahlapuu M; Leng Y; Johansson C; Galuska D; Lindgren K; Åbrink M; Stapleton D; Zierath JR; Andersson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(3):E553-E557
Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake
Al-Khalili L; Krook A; Zierath JR; Cartee GD
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2004;36(7):1212-1217
Sending the signal: Molecular mechanisms regulating glucose uptake
Krook A; Wallberg-Henriksson H; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(1):E1-E7
Branched-chain amino acids increase p70^S6k phosphorylation in human skeletal muscle after resistance exercise
Karlsson HKR; Nilsson PA; Nilsson J; Chibalin AV; Zierath JR; Blomstrand E
Article: DIABETES. 2004;53(6):1436-1444
Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice
Leng Y; Steiler TL; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2004;286(6):C1410-C1416
MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways
Al-Khalili L; Chibalin AV; Yu M; Sjödin B; Nylén C; Zierath JR; Krook A
Article: REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS. 2004;5(2):111-117
Insulin signaling defects in type 2 diabetes
Leng Y; Karlsson HKR; Zierath JR
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2004;89(3):1301-1311
Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes
Storgaard H; Jensen CB; Björnholm MB; Song XM; Madsbad S; Zierath JR; Vaag AA
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;286(2):E194-E200
Expression profiling of the γ-subunit isoforms of AMP-activated protein kinase suggests a major role for γ3 in white skeletal muscle
Mahlapuu M; Johansson C; Lindgren K; Hjälm G; Barnes BR; Krook A; Zierath JR; Andersson L; Marklund S
Article: OBESITY. 2004;12(1):25-31
Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects
Koistinen HA; Forsgren M; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2004;53(1):21-24
Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle
Perrini S; Henriksson J; Zierath JR; Widegren U
Article: ENDOCRINOLOGY. 2003;144(12):5259-5267
Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats
Steiler TL; Galuska D; Leng Y; Chibalin AV; Gilbert M; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(45):44298-44304
Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways
Ryder JW; Bassel-Duby R; Olson EN; Zierath JR
Article: DIABETOLOGIA. 2003;46(10):1324-1328
Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients
Koistinen HA; Chibalin AV; Zierath JR
Article: BEST PRACTICE AND RESEARCH: CLINICAL ENDOCRINOLOGY AND METABOLISM. 2003;17(3):385-398
The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle
Zierath JR; Kawano Y
Article: JOURNAL OF PHYSIOLOGY. 2003;550(1):305-315
Insulin signalling and resistance in patients with chronic heart failure
Kemppainen J; Tsuchida H; Stolen K; Karlsson H; Björnholm M; Heinonen OJ; Nuutila P; Krook A; Knuuti J; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(19):17190-17197
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism -: A novel regulatory mechanism altered in obesity
Bach D; Pich S; Soriano FX; Vega N; Baumgartner B; Oriola J; Daugaard JR; Lloberas J; Camps M; Zierath JR; Rabasa-Lhoret R; Wallberg-Henriksson H; Laville M; Palacín M; Vidal H; Rivera F; Brand M; Zorzano A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(5):991-998
Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content
Al-Khalili L; Chibalin AV; Kannisto K; Zhang BB; Permert J; Holman GD; Ehrenborg E; Ding VDH; Zierath JR; Krook A
Article: DIABETES. 2003;52(5):1066-1072
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes
Koistinen HA; Galuska D; Chibalin AV; Yang J; Zierath JR; Holman GD; Wallberg-Henriksson H
Article: PANCREAS. 2003;26(2):173-177
Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle cancer patients
Isaksson B; Strömmer L; Friess H; Büchler MW; Herrington MK; Wang F; Zierath JR; Wallberg-Henriksson H; Larsson J; Pennert J
Article: JOURNAL OF PHYSIOLOGY. 2003;546(2):327-335
Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise
Yu M; Stepto NK; Chibalin AV; Fryer LGD; Carling D; Krook A; Hawley JA; Zierath JR
Article: DIABETOLOGIA. 2002;45(12):1697-1702
Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans
Björnholm M; He AR; Attersand A; Lake S; Liu SCH; Lienhard GE; Taylor S; Arner P; Zierath JR
Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;445(1):25-31
Gene expression of the p85α regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects
Tsuchida H; Björnholm M; Fernström M; Galuska D; Johansson P; Wallberg-Henriksson H; Zierath JR; Lake S; Krook A
Article: DIABETES. 2002;51(9):2703-2708
Isoform-specific regulation of 5′ AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction
Barnes BR; Ryder JW; Steiler TL; Fryer LGD; Carling D; Zierath JR
Article: DIABETOLOGIA. 2002;45(8):1128-1135
Insulin signal transduction and glucose transport in human adipocytes:: effects of obesity and low calorie diet
Björnholm M; Al-Khalili L; Dicker A; Näslund E; Rössner S; Zierath JR; Arner P
Article: DIABETOLOGIA. 2002;45(1):56-65
5-aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice
Song XM; Fiedler M; Galuska D; Ryder JW; Fernström M; Chibalin AV; Wallberg-Henriksson H; Zierath JR
Article: DIABETOLOGIA. 2001;44(12):2180-2186
5-aminoimidazole-4-carboxy-amide-1-β-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKA^y-CETP mice
Fiedler M; Zierath JR; Selén G; Wallberg-Henriksson H; Liang Y; Sakariassen KS
Article: DIABETES. 2001;50(12):2770-2778
Insulin signal transduction in skeletal muscle from glucose-intolerant relatives with type 2 diabetes
Storgaard H; Song XM; Jensen CB; Madsbad S; Björnholm M; Vaag A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2001;281(6):E1255-E1259
Evidence against high glucose as a mediator of ERK1/2 or p38 MAPK phosphorylation in rat skeletal muscle
Kawano Y; Ryder JW; Rincon J; Zierath JR; Krook A; Wallberg-Henriksson H
Article: JOURNAL OF PHYSIOLOGY. 2001;536(1):273-282
Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle
Yu M; Blomstrand E; Chibalin AV; Krook A; Zierath JR
Article: ENDOCRINOLOGY. 2001;142(8):3474-3482
Insulin- and glucose-induced phosphorylation of the Na⁺,K⁺-adenosine triphosphatase α-subunits in rat skeletal muscle
Chibalin AV; Kovalenko MV; Ryder JW; Féraille E; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2001;50(5):1149-1157
Isomer-specific antidiabetic properties of conjugated linoleic acid - Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression
Ryder JW; Portocarrero CP; Song XM; Cui L; Yu M; Combatsiaris T; Galuska D; Bauman DE; Barbano DM; Charron MJ; Zierath JR; Houseknecht KL
Article: THE FASEB JOURNAL. 2001;15(6):958-969
Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity
Tsao TS; Li J; Chang KS; Stenbit AE; Galuska D; Anderson JE; Zierath JR; McCarter RJ; Charron MJ
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2001;90(1):29-34
Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport
Yu M; Blomstrand E; Chibalin AV; Wallberg-Henriksson H; Zierath JR; Krook A
Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2000;279(5):R1716-R1721
Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle
Krook A; Widegren U; Jiang XJ; Henriksson J; Wallberg-Henriksson H; Alessi D; Zierath JR
Article: HUMAN MOLECULAR GENETICS. 2000;9(14):2149-2158
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
Fakhrai-Rad H; Nikoshkov A; Kamel A; Fernström M; Zierath JR; Norgren S; Luthman H; Galli J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2000;279(1):E206-E212
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle
Del Aguila LF; Krishnan RK; Ulbrecht JS; Farrell PA; Correll PH; Lang CH; Zierath JR; Kirwan JP
Article: DIABETES. 2000;49(4):647-654
Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients
Ryder JW; Yang J; Galuska D; Rincón J; Björnholm M; Krook A; Lund S; Pedersen O; Wallberg-Henriksson H; Zierath JR; Holman GD
Article: DIABETES. 2000;49(2):284-292
Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
Krook A; Björnholm M; Galuska D; Jiang XJ; Fahlman R; Myers MG; Wallberg-Henriksson H; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(2):1457-1462
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle - Involvement of the mitogen- and stress-activated protein kinase 1
Ryder JW; Fahlman R; Wallberg-Henriksson H; Alessi DR; Krook A; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(1):38-43
Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
Chibalin AV; Yu M; Ryder JW; Song XM; Galuska D; Krook A; Wallberg-Henriksson H; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1999;277(6):R1690-R1696
Muscle fiber type specificity in insulin signal transduction
Song XM; Ryder JW; Kawano Y; Chibalin AV; Krook A; Zierath JR
Article: THE FASEB JOURNAL. 1999;13(15):2246-2256
Postexercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4-deficient mice
Ryder JW; Kawano Y; Galuska D; Fahlman R; Wallberg-Henriksson H; Charron MJ; Zierath JR
Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 1999;439(1-2):130-133
Effect of the nicotine metabolite 5′-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle
Rincón J; Galuska D; Ryder JW; Kawano Y; Wallberg-Henriksson H; Gorrod JW; Zierath JR
Article: BIOCHEMICAL JOURNAL. 1999;342(Pt 2):321-328
In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle
Ryder JW; Kawano Y; Chibalin AV; Rincón J; Tsao TS; Stenbit AE; Combatsiaris T; Yang J; Holman GD; Charron MJ; Zierath JR
Article: DIABETOLOGIA. 1999;42(9):1071-1079
Changes in glucose transport and protein kinase Cβ₂ in rat skeletal muscle induced by hyperglycaemia
Kawano Y; Rincon J; Soler A; Ryder JW; Nolte LA; Zierath JR; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1999;42(Suppl 1):a1-a330
35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999.
Article: DIABETOLOGIA. 1999;42(7):826-830
Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects
Hjeltnes N; Fernström M; Zierath JR; Krook A
Article: SCIENCE. 1999;284(5416):974-977
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice
Zhang B; Salituro G; Szalkowski D; Li ZH; Zhang Y; Royo I; Vilella D; Díez MT; Pelaez F; Ruby C; Kendall RL; Mao XZ; Griffin P; Calaycay J; Zierath JR; Heck JV; Smith RG; Moller DE
Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 1999;19(2):135-142
Altered skeletal muscle glucose transport and blood lipid levels in habitual cigarette smokers
Rincón J; Krook A; Galuska D; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1999;48(3):664-670
Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats
Song XM; Kawano Y; Krook A; Ryder JW; Efendic S; Roth RA; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1999;48(2):310-320
Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.
Kim YB; Zhu JS; Zierath JR; Shen HQ; Baron AD; Kahn BB
Article: ENDOCRINOLOGY. 1998;139(12):5034-5041
Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARγ agonist) action
Zierath JR; Ryder JW; Doebber T; Woods J; Wu M; Ventre J; Li ZH; McCrary C; Berger J; Zhang B; Moller DE
Article: THE FASEB JOURNAL. 1998;12(15):1701-1712
Exercise-induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons:: molecular mechanism for improved glucose homeostasis
Hjeltnes N; Galuska D; Björnholm M; Aksnes AK; Lannem A; Zierath JR; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1998;41(11):1343-1354
Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes:: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway
Zierath JR; Livingston JN; Thörne A; Bolinder J; Reynisdottir S; Lönnqvist F; Arner P
Article: THE FASEB JOURNAL. 1998;12(13):1379-1389
Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle
Widegren U; Jiang XJ; Krook A; Chibalin AV; Björnholm M; Tally M; Roth RA; Henriksson J; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1998;47(9):1528-1531
Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients
Krook A; Digby J; O'Rahilly S; Zierath JR; Wallberg-Henriksson H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(33):20910-20915
Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation
Zierath JR; Tsao TS; Stenbit AE; Ryder JW; Galuska D; Charron MJ
Article: DIABETES. 1998;47(8):1281-1286
Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
Krook A; Roth RA; Jiang XJ; Zierath JR; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1998;275(2):e351-e358
Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport
Strommer L; Permert J; Arnelo U; Koehler C; Isaksson B; Larsson J; Lundkvist I; Bjornholm M; Kawano Y; Wallberg-Henriksson H; Zierath JR
Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1998;182(1-2):153-160
Insulin action in skeletal muscle from patients with NIDDM
Zierath JR; Krook A; Wallberg-Henriksson H
Article: MOLECULAR BIOLOGY OF THE CELL. 1998;9(5):1209-1220
Phosphatidylinositol 3-kinase-mediated endocytosis of renal Na⁺,K⁺-ATPase α subunit in response to dopamine
Chibalin AV; Zierath JR; Katz AI; Berggren PO; Bertorello AM
Article: DIABETES. 1998;47(1):1-4
Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes
Zierath JR; Frevert EU; Ryder JW; Berggren PO; Kahn BB
Article: DIABETES. 1997;46(12):2110-2114
Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats
Krook A; Kawano Y; Song XM; Efendic S; Roth RA; WallbergHenriksson H; Zierath JR
Article: DIABETES. 1997;46(12):1965-1969
Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique
Lund S; Holman GD; Zierath JR; Rincon J; Nolte LA; Clark AE; Schmitz O; Pedersen O; WallbergHenriksson H
Article: DIABETOLOGIA. 1997;40(10):1172-1177
Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism
Shepherd PR; Nave BT; Rincon J; Haigh RJ; Foulstone E; Proud C; Zierath JR; Siddle K; WallbergHenriksson H
Article: JOURNAL OF CLINICAL INVESTIGATION. 1997;100(3):671-677
Muscle-specific transgenic complementation of GLUT4-deficient mice - Effects on glucose but not lipid metabolism
Tsao TS; Stenbit AE; Li J; Houseknecht KL; Zierath JR; Katz EB; Charron MJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(30):19000-19007
Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.
Shepherd PR; Nave BT; Rincon J; Nolte LA; Bevan AP; Siddle K; Zierath JR; WallbergHenriksson H
Article: DIABETES. 1997;46(3):524-527
Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
Bjornholm M; Kawano Y; Lehtihet M; Zierath JR
Article: DIABETOLOGIA. 1996;39(10):1180-1189
Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
Zierath JR; He L; Guma A; Wahlstrom EO; Klip A; WallbergHenriksson H
Article: JOURNAL OF INTERNAL MEDICINE. 1996;240(3):115-124
C-peptide revisited - New physiological effects and therapeutic implications
Wahren J; Johansson BL; WallbergHenriksson H; Linde B; FernqvistForbes E; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1996;271(3):E593-E600
Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients
Aksnes AK; Hjeltnes N; Wahlstrom EO; Katz A; Zierath JR; WallbergHenriksson H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(19):11347-11355
Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin.
Houseknecht KL; Zhu AX; Gnudi L; Hamann A; Zierath JR; Tozzo E; Flier JS; Kahn BB
Article: DIABETES. 1996;45(5):615-621
Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment
Rincon J; Holmang A; Wahlstrom EO; Lonnroth P; Bjorntorp P; Zierath JR; WallbergHenriksson H
Article: DIABETOLOGIA. 1996;39(3):306-313
C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin receptor and tyrosine kinase activation
Zierath JR; Handberg A; Tally M; WallbergHenriksson H
Article: BIOCHEMICAL JOURNAL. 1995;311(Pt 2):517-521
CARRIER-MEDIATED FRUCTOSE UPTAKE SIGNIFICANTLY CONTRIBUTES TO CARBOHYDRATE-METABOLISM IN HUMAN SKELETAL-MUSCLE
ZIERATH JR; NOLTE LA; WAHLSTROM E; GALUSKA D; SHEPHERD PR; KAHN BB; WALLBERGHENRIKSSON H
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1995;268(4):E613-E622
INSULIN INDUCES TRANSLOCATION OF GLUT-4 GLUCOSE TRANSPORTERS IN HUMAN SKELETAL-MUSCLE
GUMA A; ZIERATH JR; WALLBERGHENRIKSSON H; KLIP A
Article: DIABETES. 1995;44(3):347-353
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Echwald SM; Bjørbaek C; Hansen T; Clausen JO; Vestergaard H; Zierath JR; Printz RL; Granner DK; Pedersen O
Article: CLINICAL SCIENCE. 1995;88(3):301-306
DEVELOPMENT OF DECREASED INSULIN-INDUCED GLUCOSE-TRANSPORT IN SKELETAL-MUSCLE OF GLUCOSE-INTOLERANT HYBRIDS OF DIABETIC GK RATS
NOLTE LA; ABDELHALIM SM; MARTIN IK; GUENIFI A; ZIERATH JR; OSTENSON CG; WALLBERGHENRIKSSON H
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All other publications

Letter: CELL METABOLISM. 2024;36(5):882-883
Exploratory physiological experiments are not clinical trials
Richter EA; James DE; Kirwan JP; Zierath JR
Review: CELL METABOLISM. 2024;36(2):278-300
Exercise induces tissue-specific adaptations to enhance cardiometabolic health
Ashcroft SP; Stocks B; Egan B; Zierath JR
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2023;24(9):607-632
Exercise metabolism and adaptation in skeletal muscle
Smith JAB; Murach KA; Dyar KA; Zierath JR
Letter: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(11):713
Reply to 'Lactate as a major myokine and exerkine'
Chow LS; Gerszten RE; Taylor JM; Pedersen BK; van Praag H; Trappe S; Febbraio MA; Galis ZS; Gao Y; Haus JM; Lanza IR; Lavie CJ; Lee C-H; Lucia A; Moro C; Pandey A; Robbins JM; Stanford KI; Thackray AE; Villeda S; Watt MJ; Xia A; Zierath JR; Goodpaster BH; Snyder M
Review: ENDOCRINE REVIEWS. 2022;43(4):654-677
Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity
Stocks B; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(5):273-289
Exerkines in health, resilience and disease
Chow LS; Gerszten RE; Taylor JM; Pedersen BK; van Praag H; Trappe S; Febbraio MA; Galis ZS; Goo Y; Haus JM; Lanza IR; Lavie CJ; Lee C-H; Lucia A; Moro C; Pandey A; Robbins JM; Stanford KI; Thackray AE; Villeda S; Watt MJ; Xia A; Zierath JR; Goodpaster BH; Snyder MP
Review: JOURNAL OF PHYSIOLOGY. 2022;600(5):1027-1036
Zeitgebers of skeletal muscle and implications for metabolic health
Gabriel BM; Zierath JR
Editorial comment: METABOLISM: CLINICAL AND EXPERIMENTAL. 2021;119:154769
COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pandemic
Tessier CM; Kokkinos A; Mingrone G; Koliaki C; Zierath JR; Mantzoros CS
Review: CELL. 2021;184(6):1530-1544
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
Pillon NJ; Loos RJF; Marshall SM; Zierath JR
Review: CURRENT OPINION IN LIPIDOLOGY. 2021;32(1):16-23
The role of the molecular circadian clock in human energy homeostasis
Dollet L; Pendergrast LA; Zierath JR
Review: DIABETOLOGIA. 2020;63(11):2253-2259
Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men
Hawley JA; Sassone-Corsi P; Zierath JR
Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):5142
Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.
Lundell LS; Parr EB; Devlin BL; Ingerslev LR; Altıntaş A; Sato S; Sassone-Corsi P; Barrès R; Zierath JR; Hawley JA
Review: DIABETOLOGIA. 2020;63(8):1491-1499
Train like an athlete: applying exercise interventions to manage type 2 diabetes
Savikj M; Zierath JR
Editorial comment: CURRENT DIABETES REPORTS. 2019;19(11):118
Major Advances and Discoveries in Diabetes-2019 in Review
Zierath JR
Corrigendum: JOURNAL OF ENDOCRINOLOGY. 2019;243(2):X1
The estrogen receptor α-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice: potential molecular mechanisms (vol 199, pg 275, 2008)
Lundholm L; Bryzgalova G; Gao H; Portwood N; Falt S; Berndt KD; Dicker A; Galuska D; Zierath JR; Gustafsson J-A; Efendic S; Dahlman-Wright K; Khan A
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2019;30(9):603-617
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis
Massart J; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2019;15(4):197-206
Circadian rhythms and exercise - re-setting the clock in metabolic disease
Gabriel BM; Zierath JR
Review: JOURNAL OF PHYSIOLOGY. 2019;597(6):1439-1450
Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue
Dollet L; Zierath JR
Other: CELL METABOLISM. 2018;28(3):329
John O. Holloszy (1933-2018) Obituary
Zierath JR; Hagberg JM; Coyle EF
Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):5008
Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans (vol 7, 2017)
Laker RC; Garde C; Camera DM; Smiles WJ; Zierath JR; Hawley JA; Barres R
Editorial comment: CELL METABOLISM. 2017;25(5):978-984
Exercise Metabolism
Stanford K; Loos R; Evans R; Zierath JR; Leinwand LA; Rosenzweig A; Spiegelman B; Mott R; Helenius T; Febbraio MA; Weigert C; Goodpaster BH; Granger A; Panda S; Joyner MJ; Gibala M; Hawley J; Messmer-Blust A; Emambokus N
Review: CELL METABOLISM. 2017;25(5):1000-1011
The Limits of Exercise Physiology: From Performance to Health
Gabriel BM; Zierath JR
Editorial comment: CELL. 2016;167(5):1155-1158
Building Bridges through Scientific Conferences
Zierath JR
Editorial comment: CELL METABOLISM. 2016;24(2):342-342.e1
SnapShot: Exercise Metabolism
Egan B; Hawley JA; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2016;12(8):441-451
The role of diet and exercise in the transgenerational epigenetic landscape of T2DM
Barres R; Zierath JR
Review: CELL METABOLISM. 2016;23(6):1034-1047
Exercise Promotes Healthy Aging of Skeletal Muscle
Cartee GD; Hepple RT; Bamman MM; Zierath JR
Corrigendum: DIABETOLOGIA. 2015;58(12):2899
Turning the page (vol 58, pg 2685, 2015)
Zierath JR
Editorial comment: DIABETOLOGIA. 2015;58(12):2685-2687
Turning the page
Zierath JR
Editorial comment: DIABETOLOGIA. 2015;58(8):1685-1687
Diabetologia at 50: celebrating half a century of progress in diabetes research and care
Zierath JR
Review: CELL METABOLISM. 2015;22(1):25-30
Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?
Zierath JR; Wallberg-Henriksson H
Editorial comment: CELL METABOLISM. 2015;21(5):654-657
Women in Metabolism: Part I
Kahn B; Simon MC; Zhang BB; Zierath JR; Muoio DM; Moore KJ; Cannon B; Haigis M; Schoonjans K; Mandrup S; Clement K; Andrews NC
Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2015;11(4):198-200
Exercise remodels subcutaneous fat tissue and improves metabolism
Wallberg-Henriksson H; Zierath JR
Other: CELL. 2015;161(1):173-174
How to Stop the Obesity Epidemic?
Chen Z; Zierath J; Kahn CR; Spiegelman B; O'Rahilly S; Bruning JC
Review: CELL. 2014;159(4):738-749
Integrative Biology of Exercise
Hawley JA; Hargreaves M; Joyner MJ; Zierath JR
Review: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2014;307(9):C774-C787
Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes
Al-Khalili L; Barbosa TDC; Ostling J; Massart J; Garrido Cuesta P; Osler ME; Katayama M; Nystrom A-C; Oscarsson J; Zierath JR
Review: DRUG DISCOVERY TODAY. 2014;19(7):1010-1014
Dynamic epigenetic responses to muscle contraction
Rasmussen M; Zierath JR; Barres R
Corrigendum: CELL REPORTS. 2013;3(5):1755
Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation (vol 3, pg 1020, 2013)
Barres R; Kirchner H; Rasmussen M; Yan J; Kantor FR; Krook A; Naslund E; Zierath JR
Review: TRENDS IN CELL BIOLOGY. 2013;23(5):203-209
Epigenetic flexibility in metabolic regulation: disease cause and prevention?
Kirchner H; Osler ME; Krook A; Zierath JR
Review: CELL METABOLISM. 2013;17(2):162-184
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan B; Zierath JR
Editorial comment: DIABETOLOGIA. 2012;55(1):1-2
Remembering our classics: then and now
Zierath JR
Published conference paper: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2011;93(4):897S-8900
DNA methylation in metabolic disorders
Barres R; Zierath JR
Editorial comment: DIABETOLOGIA. 2011;54(1):1-3
Keeping ahead of the fast pace of science
Zierath JR
Review: LAKARTIDNINGEN. 2010;107(45):2802-2805
[Molecular mechanisms underlying insulin resistance in skeletal muscle].
Zierath JR; Krook A
Review: DIABETOLOGIA. 2009;52(7):1231-1239
Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA
Krook A; Zierath JR
Editorial comment: CELL. 2009;137(1):22-24
A New Twist on Brown Fat Metabolism
Wallberg-Henriksson H; Zierath JR
Published conference paper: INTERNATIONAL JOURNAL OF OBESITY. 2008;32:S18-S23
Exercise-induced phospho-proteins in skeletal muscle
Deshmukh AS; Hawley JA; Zierath JR
Review: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2008;295(3):E545-E552
Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle
Long YC; Zierath JR
Review: ENDOCRINOLOGY. 2008;149(3):935-941
Minireview:: Adenosine 5′-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle
Osler ME; Zierath JR
Editorial comment: ACTA PHYSIOLOGICA. 2008;192(1):1
Xth International Symposium on Insulin Receptors and Insulin Action
Zierath JR
Editorial comment: DIABETOLOGIA. 2007;50(7):1362-1364
Fighting the battle of the bulge: exercise training in early-onset type 2 diabetes
Osler ME; Zierath JR
Editorial comment: CELL METABOLISM. 2007;5(3):161-163
The path to insulin resistance: Paved with ceramides?
Zierath JR
Published conference paper: CELL BIOCHEMISTRY AND BIOPHYSICS. 2007;48(2-3):103-113
Insulin signaling and glucose transport in insulin resistant human skeletal muscle
Karlsson HKR; Zierath JR
Review: ESSAYS IN BIOCHEMISTRY. 2006;42:1-12
Signalling mechanisms in skeletal muscle: Role in substrate selection and muscle adaptation
Hawley JA; Hargreaves M; Zierath JR
Review: JOURNAL OF CLINICAL INVESTIGATION. 2006;116(7):1776-1783
AMP-activated protein kinase signaling in metabolic regulation
Long YC; Zierath JR
Editorial comment: DIABETOLOGIA. 2005;48(12):2451-2453
Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling
Long YC; Zierath JR
Review: CURRENT DIABETES REVIEWS. 2005;1(2):167-174
Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes.
Bouzakri K; Koistinen HA; Zierath JR
Review: CURRENT MOLECULAR MEDICINE. 2005;5(3):341-348
Role of AMP-activated protein kinase in the control of glucose homeostasis
Barnes BR; Zierath JR
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2005;33(Pt 2):354-357
Insulin signal transduction in human skeletal muscle:: identifying the defects in type II diabetes
Björnholm M; Zierath JR
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2005;8(2):121-123
Kinases in diabetes - Part II - 11-12 November 2004, Manchester, UK
Zierath JR
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2005;8(2):118-120
Kinases in diabetes - Part I - 11-12 November 2004, Manchester, UK
Zierath JR
Editorial comment: ACTA PHYSIOLOGICA. 2005;183(1):1-2
Theme: Skeletal muscle and adipose tissue metabolism - Regulation, exercise, diabetes and ageing - Foreword
Zierath JR; Handberg A; Jensen J
Letter: ACTA PHYSIOLOGICA. 2005;183(1):125-126
Integration of mathematical and experimental approaches to resolve insulin signalling
Sögård P; Harlén M; Svensson LT; Zierath JR; Nilsson P
Editorial comment: PLOS BIOLOGY. 2004;2(10):e348
Skeletal muscle fiber type: Influence on contractile and metabolic properties
Zierath JR; Hawley JA
Published conference paper: PROCEEDINGS OF THE NUTRITION SOCIETY. 2004;63(2):227-232
Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle
Long YC; Widegren U; Zierath JR
Review: EXERCISE AND SPORT SCIENCES REVIEWS. 2004;32(1):4-8
Integration of metabolic and mitogenic signal transduction in skeletal muscle
Hawley JA; Zierath JR
Editorial comment: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2003;26(7):690-692
Skeletal muscle insulin resistance: Is it important for the pathogenesis of Type 2 diabetes after all?
Koistinen HA; Zierath JR
Review: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES. 2003;111(4):191-197
Analysis of insulin signaling pathways through comparative genomics. Mapping mechanisms for insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus
Lake S; Krook A; Zierath JR
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):219
Effects of diet and exercise on the regulation of PPARα, δ and γ expression in rat skeletal muscle and visceral adipose tissue
Kannisto K; Chibalin A; Zierath JR; Hamsten A; Ehrenborg E
Review: JOURNAL OF APPLIED PHYSIOLOGY. 2002;93(2):773-781
Exercise effects of muscle insulin signaling and action - Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle
Zierath JR
Review: THE FASEB JOURNAL. 2002;16(10):1163-1176
Analysis of paradoxical observations on the association between leptin and insulin resistance
Ceddia RB; Koistinen HA; Zierath JR; Sweeney G
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2002;967:120-134
From receptor to effector: Insulin signal transduction in skeletal muscle from type II diabetic patients
Zierath JR; Wallberg-Henriksson H
Review: ANNALS OF MEDICINE. 2002;34(6):410-418
Regulation of glucose transport in human skeletal muscle
Koistinen HA; Zierath JR
Review: ACTA PHYSIOLOGICA. 2001;172(3):227-238
Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction
Widegren U; Ryder JW; Zierath JR
Review: MOLECULAR MEMBRANE BIOLOGY. 2001;18(3):205-211
GLUT4: a key player regulating glucose homeostasis? Insights from transgenic and knockout mice
Wallberg-Henriksson H; Zierath JR
Published conference paper: ACTA PHYSIOLOGICA. 2001;171(3):249-257
Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle
Ryder JW; Chibalin AV; Zierath JR
Review: FRONTIERS IN BIOSCIENCE - LANDMARK. 2001;6:D154-D163
Skeletal muscle and insulin sensitivity: Pathophysiological alterations
Ryder JW; Gilbert M; Zierath JR
Review: DIABETOLOGIA. 2000;43(7):821-835
Insulin action and insulin resistance in human skeletal muscle
Zierath JR; Krook A; Wallberg-Henriksson H
Review: SPORTS MEDICINE. 1998;25(1):25-35
Exercise in the management of non-insulin-dependent diabetes mellitus
Wallberg-Henriksson H; Rincon J; Zierath JR
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1998;441:73-85
Insulin signaling and glucose transport in insulin resistant skeletal muscle - Special reference to GLUT4 transgenic and GLUT4 knockout mice
Galuska D; Ryder J; Kawano Y; Charron MJ; Zierath JR
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1997;25(3):963-968
Metabolic and molecular consequences of modifying GLUT4 expression in skeletal muscle
Charron MJ; Katz EB; Zierath JR
Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 1996;7(2):295-307
Glucose transporters and diabetes
Zierath JR; Houseknecht KL; Kahn BB
Other: DIABETES. 1995;44(11):1345-1348
HYPERGLYCEMIA ACTIVATES GLUCOSE-TRANSPORT IN RAT SKELETAL-MUSCLE VIA A CA2+-DEPENDENT MECHANISM
NOLTE LA; RINCON J; WAHLSTROM EO; CRAIG BW; ZIERATH JR; WALLBERGHENRIKSSON H
Review: ACTA PHYSIOLOGICA SCANDINAVICA, SUPPLEMENT. 1995;626:1-96
In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport.
Zierath JR
Review: ACTA PHYSIOLOGICA. 1995;155:11-96
IN-VITRO STUDIES OF HUMAN SKELETAL-MUSCLE - HORMONAL AND METABOLIC-REGULATION OF GLUCOSE-TRANSPORT - INTRODUCTION
ZIERATH JR
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Employments

Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2009-
Professor, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2006-

Degrees and Education

Docent, Karolinska Institutet, 1998

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