Forskargruppen IMPACT – Marie Löf

Forskargruppen IMPACT fokuserar på förebyggande av övervikt och obesitas under graviditet och barndom. Vi använder mobiltelefonteknik (mHealth) för att mäta kost och fysisk aktivitet, och för att leverera insatser som främjar en hälsosam livsstil i olika befolkningsgrupper, särskilt inom mödra- och barnhälsovården. Vår forskning inkluderar mHealth för egenvård och behandling av sjukdomar, t.ex. graviditetsdiabetes. Vi ger även utbildning i Nutrition och är en del av Centrum för Nutrition.

En del av:

Publikationer

Utvalda publikationer

Finansiering

Forskningsbidrag

  • Ett digitalt livsstilsprogram inom primärvården för att förebygga hjärt- kärl-sjukdom: Utvärdering av effekt på kardiovaskulär hälsa, hälsoekonomiska aspekter, och implementering i sjukvården
    Familjen Kamprads stiftelse
    1 mars 2025 - 1 mars 2028
  • Vetenskapsrådet
    1 januari 2025 - 31 januari 2028
  • A digital, co-designed and multilingual intervention to prevent gestational diabetes (Di-Prev): a randomised controlled trial
    Forte
    1 januari 2025 - 31 januari 2027
  • Föräldrars uppfattning och attityder till skärmtid samt genomförbarheten av en samskapad digital intervention
    Henning ochJohan Throne Holst stiftelse för främjande av vetenskaplig forskning
    1 september 2024
  • A mHealth intervention to promote healthy lifestyle behaviours from the start of life: The Health4Life trial
    Swedish Research Council for Health, Working Life and Welfare (FORTE)
    1 januari 2024 - 1 januari 2026
  • Swedish Research Council for Health Working Life and Welfare
    1 januari 2024 - 31 december 2027
    The human papillomavirus (HPV) is responsible for most cervical and anogenital cancers. The HPV vaccine can effectively reduce invasive cervical cancer
    however, HPV vaccine uptake is low in certain groups due to hesitancy and refusal, which undermines the success of the vaccine. In Sweden, HPV vaccine hesitancy has mainly been observed among parents and adolescents in socioeconomically disadvantaged communities with large immigrant populations.The purpose of this project is therefore to co-design and assess the feasibility and preliminary effects of digital health intervention tools to reduce HPV vaccine hesitancy and increase uptake of this vaccine in socioeconomically disadvantaged communities in Stockholm, Sweden. Several research questions shall assess whether a co-designed digital health intervention has the potential to improve HPV uptake, awareness and confidence.The project involves three sub-studies implemented by an interdisciplinary team.  Study 1 will involve a formative stage whereby adolescents, parents/guardians and school nurses situated in socially disadvantaged areas in Stockholm will be interviewed to understand their perspectives and concerns related to the HPV vaccine. Thereafter, study 2 will use knowledge gained from study 1 to inform the co-design phase where adolescent boys/girls and their parents/guardians are invited to develop and provide feedback on content and prototypes for digital health interventions. Finally, study 3 will involve pilot-testing of the intervention for feasibility, acceptability and preliminary effect, using a cluster-randomized design.This project is highly feasible as it builds on the study team’s previous research, which show that immigrant communities in Sweden experience poorer health outcomes as well as vaccine hesitancy. Because 1 in 5 Swedes have a migrant background this study is relevant to Swedish society. An appropriate and accessible digital health intervention has the potential to prevent cervical cancer, saving lives and reducing future burdens on an overstretched Swedish healthcare system. The results from this project will be generalizable to similar contexts in Sweden and possibily beyond.
  • European Union
    1 januari 2024 - 31 december 2027
    MELIORA Consortium will jointly work with local actors at different levels for the realization of eight (8) in total tailor-made lifestyle intervention and behavioural modification studies, including Artificial intelligence and digital tools, to promote sustainable behavioural changes among three target populations: i) healthy women at risk of developing breast cancer, ii) breast cancer patients and iii) breast cancer survivors. The studies will take place across 4 different European countries (Greece, Sweden, Spain and Lithuania) and 6 piloting centres targeting 2000 women in urban and rural areas including participants throughout the socioeconomic spectrum. Primary health care centres, hospitals or patients’/survivors’ organisations will be used as entry points to the community. The goal of the MELIORA Virtual Coach interventions is to evaluate its effectiveness, through assessing the effect of multiple individual and contextual factors to the uptake and sustainability of behavioural changes. At the same time, identification of specific bottlenecks and barriers that prevent the uptake of sustainable behavioural change will support the development of approaches on how to best reach and involve disadvantaged socio-economic population groups, vulnerable groups, and people living in rural areas, and will provide best practices for behavioural intervention uptake and scale-up. Regular monitoring will be ongoing during the implementation to allow corrective actions and ensure effective adaptation and uptake. Based on the study outcomes, the health economic evaluation and budget impact analysis, and data deriving from the scalability assessment, national and European stakeholders will be invited to evaluate, through workshops, the potential for adoption of the MELIORA Virtual Coach Interventions in other regions or countries in Europe. This action is part of the Cancer Mission cluster of projects on “Prevention & early detection (behavioural change).
  • DIGIFOOD: Improving children’s digital food environment
    UNICEF SWEDEN and Hjärt Lungfonden
    1 januari 2024 - 31 juli 2024
  • European Union
    1 november 2023 - 31 oktober 2027
    BETTER4U aims at the identification and personalized management of all weight gain determinants to battle the increasingly rising numbers of overweight/obesity, via homogenous, globally adaptable and practically assessed public health initiatives and key interventions. Building on previous key projects and biobanks, the project will focus on the hitherto neglected impact of the polygenic background of weight gain on the effectiveness of lifestyle interventions for weight management in people with overweight/obesity. BETTER4U aims to probe into the global obesity challenge, study the problem and offer solutions in a tangible realistic way with the assistance of modern AI technologies and the contribution of experts around the world. BETTER4U will be realized through the following objectives: 1. To comprehensively understand and decipher genetics, metabolomics, microbiota, socio-economic, geographical, cultural and lifestyle features linked to weight gain throughout the life course, via meta-analyses (BETTER4U data from >50 studies, >1 million individuals) and extensive literature meta-review. 2.To develop the BETTER4U intervention methodology for weight gain prevention, based on a causal AI model of obesity determinants and a pilot study in 7 European countries. 3.To deploy technology-assisted, real-time monitoring tools to measure detailed behavioral indicators and their relation to the environmental context. 4.To evaluate the efficacy of the novel BETTER4U intervention methodology in a controlled, randomized clinical trial, based on individually-tailored recommendations for lifestyle change. 5.To maximize transferability and applicability of the BETTER4U intervention methodology by identifying implementation barriers and facilitators, as well as to evaluate implementation outcomes in both participants and stakeholders. 6. To develop and disseminate the BETTER4Uobesity prevention intervention methodology guidelines using a people-centred, sustainable care approach.
  • Promoting healthy lifestyle behaviours in the first 2000 days of life to prevent overweight and obesity using mHealth interventions in primary CHC
    Karolinska Institutet (Research School in Health Sciences(
    1 september 2023 - 1 september 2027
  • Henning & Johan Throne-Holsts stiftelse
    1 augusti 2023 - 31 juli 2024
  • European Union
    1 juli 2023 - 30 juni 2027
    PREVENT improves upscaling of primary interventions for weight control management during childhood and adolescence to reduce cancer risks in adulthood. This relies on current evidence that relates excess body weight with increased cancer risk. Towards this end, PREVENT applies a series of implementation research actions in the following directions. First, it identifies barriers to current interventions and policies preventing them from upscaling to different geographical, socio-economic, and cultural settings. Then, it introduces new multi-actor and context-aware interventions along with new user engagement strategies to face the current upscaling bottlenecks
    multi-actor in the sense that they target different types of users (e.g. students, family, educators, policymakers) and context-aware in the sense that PREVENT interventions are tailored to the specific implementation places (class, canteen, sports fields, labs, outside school). The PREVENT new policies are adapted, piloted, and scaled up within the schools’ communities of three European countries facing different epidemiological settings on childhood obesity, geographic, socio-economic and cultural attributes. The pilots are designed to be holistic end-to-end ecosystems, including users, medical professionals, policymakers, public authorities, and civil communities. They focus on the whole school communities of Greece, Sweden, and Spain-Catalonia, that is, PREVENT outreach to more than 3.3 million students, required for guideline provisioning, large-scale implementation, multi-parameter assessment, and scaling-up. Co-creation, active behavioral change, self-evaluation through user empowerment, motivational interviewing, social innovation, digital-assistive engagement, health apps, and multi-domain assessment are implementation research aspects of PREVENT to advance user acceptability and compatibility with existing policies, and thus improve sustainability and upscaling. This action is part of the Cancer Mission cluster of projects on ""Prevention and Early Detection".
  • European Union
    1 maj 2023 - 30 april 2027
    During the last decades, overweight & obesity rates have reached epidemic proportions across EU. Prevalence in childhood is particularly alarming, resulting in psychological impacts & increased risks for NCDs. However, although obesity-related research has provided interesting results, several issues arise due to the lack of meta-reviews & the nature of data collected. To address this, Bio-Streams aims on supporting the optimal use (and re-use) of health data (e.g. biological, demographic, epigenetic, etc.) to generate metadata/knowledge and provide new evidences, methodologies & tools for: a) creating and deploying the Bio-Streams Biobank that will act as a scientific platform for research in obesity and better diagnostic and therapeutic approaches
    b) understanding the transition from metabolically healthy to unhealthy, preventing under age obesity
    c) designing better strategies to educate & empower young citizens for weight self-management
    d) coordinating authorities & policy makers to develop cross-sectoral solutions for health promotion & under age obesity prevention. Specifically, Bio-Streams delivers a dedicated under age obesity biobank providing real-world health data (including biospecimens, anthropometrics, behavioural and cost data) from retrospective and prospective sources, while taking into account efficient data harmonisation and standardisation principles, transforming data valorisation towards under age obesity prevention and future research. Moreover, the Bio-Streams framework for data handling, provides robust and transparent methodologies for operational procedures (data infrastructures), analysis and reporting (via meta-reviews and AI-based Apps/components, evaluated via 12 multi-site pilots (7 clinical and 5 schools)), citizen awareness and lifestyle alteration, delivering obesity prevention guidelines, knowledge generation while fostering considerable opportunities for regional and national health authorities/policymakers.
  • Administered by Universitets- och högskolerådet (UHR)
    1 november 2022 - 30 oktober 2025
  • Development and validation of the Global Adolescent and Child Physical Activity Questionnaire (GAC-PAQ): A multi-country study across six continents
    Canadian Institutes of Health Research
    1 oktober 2022 - 30 september 2025
  • Large-scale implementation of a mHealth obesity prevention program within Swedish primary child healthcare: MINISTOP 3.0
    Cancerfonden
    1 april 2022 - 31 januari 2025
  • Swedish Research Council
    1 januari 2022 - 31 december 2024
  • Swedish Research Council for Health Working Life and Welfare
    1 januari 2022 - 31 oktober 2026
    In Sweden adolescent obesity is still a public health issue. The problem is reinforced by aggressive marketing of ultra-processed foods (UPF), like fast foods and sugary drinks, however real-world research is lacking. Our own research revealed that UPF advertising is more prominent in low socioeconomic (SES) areas. Digital food marketing (mobiles, TV, computers), especially for adolescents, also appears to be relevant to the challenge.This project will associate the geographic density of UPF advertisements with SES characteristics around 18 schools in 3 Swedish cities (Study 1). The project will also evaluate (Study 2) the effects of total UPF ad exposure (outdoor and digital) in the same student populations, in association with student BMI, gender and individual objective obesogenic student behaviours (i.e., school meal skipping, food selection habits and physical activity levels). The project will use tools from our ongoing EU project (BigO: Big Data against Childhood obesity) and will recruit a sample of 300 Swedish high-school students (15-18 yrs) from 6 schools in the same cities, monitoring them for two consecutive years. The project will coordinate with school administrations, through ongoing collaborations in the BigO project. In Study 3 (qualitative), the attitudes and the awareness of school students and educators on UPF and unhealthy behaviours will be evaluated. Also, the outcomes of Studies 1 and 2, will be communicated to them through focused school engagement workshops and we will evaluate their attitudes towards novel future interventions (e.g., data-driven awareness campaigns), aiming at limiting the obesogenic effects of increased UPF marketing.The project will provide new knowledge on the associations of food marketing, health behaviors and adolescent obesity, in various SES settings. It has a strong potential to support unique new strategies for public interventions and policies, promoting population health and limiting social inequalities.
  • UNICEF SWEDEN & Hjärt Lungfonden
    1 oktober 2021 - 30 juni 2022
  • European Union
    1 april 2021 - 31 mars 2025
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