Pågående forskning i LifeGene

Publikationer baserade på LifeGene-data

LifeGene--a large prospective population-based study of global relevance.
Almqvist C, Adami HO, Franks PW, Groop L, Ingelsson E, Kere J, Lissner L, Litton JE, Maeurer M, Michaëlsson K, Palmgren J, Pershagen G, Ploner A, Sullivan PF, Tybring G, Pedersen NL
Eur J Epidemiol 2011 Jan;26(1):67-77

Is a diet low in greenhouse gas emissions a nutritious diet? - Analyses of self-selected diets in the LifeGene study.
Bälter K, Sjörs C, Sjölander A, Gardner C, Hedenus F, Tillander A
Arch Public Health 2017 ;75():17

Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus.
Basso L, Boecking B, Brueggemann P, Pedersen NL, Canlon B, Cederroth CR, Mazurek B
Front Neurosci 2020 ;14():706

Subjective hearing ability, physical and mental comorbidities in individuals with bothersome tinnitus in a Swedish population sample.
Basso L, Boecking B, Brueggemann P, Pedersen NL, Canlon B, Cederroth CR, Mazurek B
Prog Brain Res 2021 ;260():51-78

Sex Differences in Comorbidity Combinations in the Swedish Population.
Basso L, Boecking B, Neff P, Brueggemann P, Cederroth CR, Rose M, Mazurek B
Biomolecules 2022 Jul;12(7):

Physical activity may compensate for prolonged TV time regarding pulse rate-a cross-sectional study.
Beijer K, Lampa E, Sundström J, Nilsson PM, Elmståhl S, Pedersen NL, Lind L
Ups J Med Sci 2018 Dec;123(4):247-254

Interaction between physical activity and television time on blood pressure level: cross-sectional data from 45 000 individuals.
Beijer K, Lampa E, Sundström J, Nilsson PM, Elmståhl S, Pedersen NL, Lind L
J Hypertens 2018 May;36(5):1041-1050

A Validation Study of the Web-Based Physical Activity Questionnaire Active-Q Against the GENEA Accelerometer.
Bonn SE, Bergman P, Trolle Lagerros Y, Sjölander A, Bälter K
JMIR Res Protoc 2015 Jul;4(3):e86

Feasibility of a novel web-based physical activity questionnaire for young children.
Bonn SE, Surkan PJ, Lagerros YT, Bälter K
Pediatr Rep 2012 Dec;4(4):e37

How valid are Web-based self-reports of weight?
Bonn SE, Trolle Lagerros Y, Bälter K
J Med Internet Res 2013 Apr;15(4):e52

Active-Q: validation of the web-based physical activity questionnaire using doubly labeled water.
Bonn SE, Trolle Lagerros Y, Christensen SE, Möller E, Wright A, Sjölander A, Bälter K
J Med Internet Res 2012 Feb;14(1):e29

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.
Bryois J, Skene NG, Hansen TF, Kogelman LJA, Watson HJ, Liu Z, , , , Brueggeman L, Breen G, Bulik CM, Arenas E, Hjerling-Leffler J, Sullivan PF
Nat Genet 2020 May;52(5):482-493

Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus.
Cederroth CR, Hong MG, Freydin MB, Edvall NK, Trpchevska N, Jarach C, Schlee W, Schwenk JM, Lopez-Escamez JA, Gallus S, Canlon B, Bulla J, Williams FMK
J Assoc Res Otolaryngol 2023 Dec;24(6):593-606

Association between Hyperacusis and Tinnitus.
Cederroth CR, Lugo A, Edvall NK, Lazar A, Lopez-Escamez JA, Bulla J, Uhlen I, Hoare DJ, Baguley DM, Canlon B, Gallus S
J Clin Med 2020 Jul;9(8):

Relative validity of micronutrient and fiber intake assessed with two new interactive meal- and Web-based food frequency questionnaires.
Christensen SE, Möller E, Bonn SE, Ploner A, Bälter O, Lissner L, Bälter K
J Med Internet Res 2014 Feb;16(2):e59

Two new meal- and web-based interactive food frequency questionnaires: validation of energy and macronutrient intake.
Christensen SE, Möller E, Bonn SE, Ploner A, Wright A, Sjölander A, Bälter O, Lissner L, Bälter K
J Med Internet Res 2013 Jun;15(6):e109

Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy.
Clements CC, Karlsson R, Lu Y, Juréus A, Rück C, Andersson E, Boberg J, Pedersen NL, Bulik CM, Nordenskjöld A, Pålsson E, Sullivan PF, Landén M
Mol Psychiatry 2021 Jun;26(6):2429-2439

Cohort profile: The Obesity and Disease Development Sweden (ODDS) study, a pooled cohort.
da Silva M, Fritz J, Mboya IB, Sun M, Wahlström J, van Guelpen B, Michaëlsson K, Magnusson PKE, Melander O, Sandin S, Yin W, Trolle Lagerros Y, Nwaru B, Leppert J, Chabok A, Pedersen NL, Elmståhl S, Isaksson K, Ingvar C, Hedman L, Backman H, Häggström C, Stocks T
BMJ Open 2024 Jul;14(7):e084836

Reference Intervals for Fecal Calprotectin in Pregnant Women Using a Particle Enhanced Turbidimetric Assay.
Fall T, Hedman A, Pershagen G, Andolf E, Almqvist C, Helmersson-Karlqvist J, Larsson A
Clin Lab 2019 Jul;65(7):

DNA Methylation Trajectories During Pregnancy.
Gruzieva O, Merid SK, Chen S, Mukherjee N, Hedman AM, Almqvist C, Andolf E, Jiang Y, Kere J, Scheynius A, Söderhäll C, Ullemar V, Karmaus W, Melén E, Arshad SH, Pershagen G
Epigenet Insights 2019 ;12():2516865719867090

Quality of life in the limelight: a study protocol of a Swedish register-based cohort study on quality of life after an injury.
Hasselberg M, Rissanen R
BMJ Open 2019 Sep;9(9):e031023

Allergen-specific IgE over time in women before, during and after pregnancy.
Hedman AM, Lundholm C, Scheynius A, Alm J, Andolf E, Pershagen G, Almqvist C
Allergy 2019 Mar;74(3):625-628

Longitudinal plasma inflammatory proteome profiling during pregnancy in the Born into Life study.
Hedman AM, Lundholm C, Andolf E, Pershagen G, Fall T, Almqvist C
Sci Rep 2020 Oct;10(1):17819

Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality.
Hong MG, Dodig-Crnković T, Chen X, Drobin K, Lee W, Wang Y, Edfors F, Kotol D, Thomas CE, Sjöberg R, Odeberg J, Hamsten A, Silveira A, Hall P, Nilsson P, Pawitan Y, Uhlén M, Pedersen NL, Hägg S, Magnusson PK, Schwenk JM
Life Sci Alliance 2020 Oct;3(10):

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.
Hübel C, Gaspar HA, Coleman JRI, Hanscombe KB, Purves K, Prokopenko I, Graff M, Ngwa JS, Workalemahu T, , , , , , , , , , , , , , O'Reilly PF, Bulik CM, Breen G
Nat Commun 2019 Dec;10(1):5765

One size does not fit all. Genomics differentiates among anorexia nervosa, bulimia nervosa, and binge-eating disorder.
Hübel C, Abdulkadir M, Herle M, Loos RJF, Breen G, Bulik CM, Micali N
Int J Eat Disord 2021 May;54(5):785-793

Polygenic association with severity and long-term outcome in eating disorder cases.
Johansson T, Birgegård A, Zhang R, Bergen SE, Landén M, Petersen LV, Bulik CM, Hübel C
Transl Psychiatry 2022 Feb;12(1):61

Mapping anorexia nervosa genes to clinical phenotypes.
Johnson JS, Cote AC, Dobbyn A, Sloofman LG, Xu J, Cotter L, Charney AW, , Birgegård A, Jordan J, Kennedy M, Landén M, Maguire SL, Martin NG, Mortensen PB, Thornton LM, Bulik CM, Huckins LM
Psychol Med 2023 Apr;53(6):2619-2633

Oral Microbiota Development in Early Childhood.
Kennedy B, Peura S, Hammar U, Vicenzi S, Hedman A, Almqvist C, Andolf E, Pershagen G, Dicksved J, Bertilsson S, Fall T
Sci Rep 2019 Dec;9(1):19025

Association of Maternal DNA Methylation and Offspring Birthweight.
Kheirkhah Rahimabad P, Arshad SH, Holloway JW, Mukherjee N, Hedman A, Gruzieva O, Andolf E, Kere J, Pershagen G, Almqvist C, Jiang Y, Chen S, Karmaus W
Reprod Sci 2021 Jan;28(1):218-227

Early life factors and variation in adult kidney function in the Swedish LifeGene cohort.
Laucyte-Cibulskiene A, Hägg S, Christensson A, Nilsson PM
Sci Rep 2025 Feb;15(1):5046

Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors-Results from multiple Swedish studies.
Lind L, Zethelius B, Lindberg E, Pedersen NL, Byberg L
PLoS One 2021 ;16(8):e0256476

Paternal DNA Methylation May Be Associated With Gestational Age at Birth.
Luo R, Mukherjee N, Chen S, Jiang Y, Arshad SH, Holloway JW, Hedman A, Gruzieva O, Andolf E, Pershagen G, Almqvist C, Karmaus WJ
Epigenet Insights 2020 ;13():2516865720930701

The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum.
Mahjani B, Klei L, Mattheisen M, Halvorsen MW, Reichenberg A, Roeder K, Pedersen NL, Boberg J, de Schipper E, Bulik CM, Landén M, Fundín B, Mataix-Cols D, Sandin S, Hultman CM, Crowley JJ, Buxbaum JD, Rück C, Devlin B, Grice DE
Am J Psychiatry 2022 Mar;179(3):216-225

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.
Mullins N, Kang J, Campos AI, et al.
Biol Psychiatry 2022 Feb;91(3):313-327

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Munn-Chernoff MA, Johnson EC, Chou YL, et al.
Addict Biol 2021 Jan;26(1):e12880Publications based on LifeGene data

Variation in the μ-Opioid Receptor Gene (OPRM1) Does Not Moderate Social-Rejection Sensitivity in Humans.
Persson E, Asutay E, Heilig M, Löfberg A, Pedersen N, Västfjäll D, Tinghög G
Psychol Sci 2019 Jul;30(7):1050-1062

Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study.
Peura S, Fall T, Almqvist C, Andolf E, Hedman A, Pershagen G, Helmersson-Karlqvist J, Larsson A
Scand J Clin Lab Invest 2018 ;78(1-2):120-124

Quality and learning aspects of the first 9000 spirometries of the LifeGene study.
Qvarfordt M, Anderson M, Svartengren M
NPJ Prim Care Respir Med 2018 Feb;28(1):6

A snapshot of an eCohort: A comparison of the LifeGene population at baseline with the Swedish general population.
Rissanen R
Scand J Public Health 2022 Nov;50(7):930-934

"I knew who I was this morning, but I've changed a few times since then": A study combining register and self-reported QoL data in assessing how response shift may occur in an injury population.
Rissanen R, Warnqvist A, Hasselberg M
Soc Sci Med 2023 Jun;326():115916

Associations between birth weight and adult apolipoproteins: The LifeGene cohort.
Sharma S, Bennet L, Laucyte-Cibulskiene A, Christensson A, Nilsson PM
PLoS One 2024 ;19(3):e0299725

Diet-related greenhouse gas emissions assessed by a food frequency questionnaire and validated using 7-day weighed food records.
Sjörs C, Raposo SE, Sjölander A, Bälter O, Hedenus F, Bälter K
Environ Health 2016 Feb;15():15

Limited association between markers of stress during pregnancy and fetal growth in 'Born into Life', a new prospective birth cohort.
Smew AI, Hedman AM, Chiesa F, Ullemar V, Andolf E, Pershagen G, Almqvist C
Acta Paediatr 2018 Jun;107(6):1003-1010

Genome-wide association study identifies new loci associated with OCD.
Strom NI, Halvorsen MW, Tian C, Rück C, Kvale G, Hansen B, Bybjerg-Grauholm J, Grove J, Boberg J, Nissen JB, Damm Als T, Werge T, de Schipper E, Fundin B, Hultman C, Höffler KD, Pedersen N, Sandin S, Bulik C, Landén M, Karlsson E, Hagen K, Lindblad-Toh K, , , , Hougaard DM, Meier SM, Hellard SL, Mors O, Børglum AD, Haavik J, Hinds DA, Mataix-Cols D, Crowley JJ, Mattheisen M
medRxiv 2024 Mar;():

Significance and Interrelationship of the Symptoms Listed in the DSM Criteria for Premenstrual Dysphoric Disorder.
Studer E, Nilsson S, Westman A, Pedersen NL, Eriksson E
Psychiatr Res Clin Pract 2023 ;5(3):105-113

Insomnia symptoms and asthma control-Interrelations and importance of comorbidities.
Sundbom F, Malinovschi A, Lindberg E, Almqvist C, Janson C
Clin Exp Allergy 2020 Feb;50(2):170-177

Antibodies against Phosphorylcholine and Malondialdehyde during the First Two Years of Life.
Thiagarajan D, Lundström SL, Pershagen G, Almqvist C, Andolf E, Hedman A, Berg O, Oparina N, Frostegård J
J Immunol 2020 Oct;205(8):2109-2116

DNA methylation differences at birth after conception through ART.
Tobi EW, Almqvist C, Hedman A, Andolf E, Holte J, Olofsson JI, Wramsby H, Wramsby M, Pershagen G, Heijmans BT, Iliadou AN
Hum Reprod 2021 Jan;36(1):248-259

Subjective and clinically assessed hearing loss; a cross-sectional register-based study on a swedish population aged 18 through 50 years.
Videhult Pierre P, Johnson AC, Fridberger A
PLoS One 2015 ;10(4):e0123290

Common Genetic Variation and Age of Onset of Anorexia Nervosa.
Watson HJ, Thornton LM, Yilmaz Z, et al.
Biol Psychiatry Glob Open Sci 2022 Oct;2(4):368-378

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
Watson HJ, Yilmaz Z, Thornton LM, et al.
Nat Genet 2019 Aug;51(8):1207-1214

Association between inflammatory biomarkers before pregnancy and risk of perinatal depression: A prospective cohort study of 4483 women in Sweden.
Zhou J, Bränn E, Hysaj E, Seitz C, Hou Y, Song H, Bergstedt J, Chang Z, Fang F, Pedersen NL, Valdimarsdóttir UA, Lu D
J Affect Disord 2025 Jan;368():477-486