MWLC Publications

The publications from Ming Wai Lau Centre for Reparative Medicine reflect collaborative efforts both within and outside of KI. The selected publications are sorted by researchers.

Gonçalo Castelo-Branco

Bonetti, A., Agostini, F., Suzuki, A. M., Hashimoto, K., Pascarella, G., Gimenez, J., Roos, L., Nash, A. J., Ghilotti, M., Cameron, C. J. F., Valentine, M., Medvedeva, Y. A., Noguchi, S., Agirre, E., Kashi, K., Samudyata, Luginbühl, J., Cazzoli, R., Agrawal, S., …Carninci, P. (2020). RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions. Nature Communications, 11(1), 1018.

Falcão, A. M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Larsen, S. C., Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A. A. S. F., Ernfors, P., Castro, D. S., Nielsen, M. L., Casaccia, P., &Castelo-Branco, G. (2019). PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 27(4), 1090-1102.e10.

Falcão, A. M., vanBruggen, D., Marques, S., Meijer, M., Jäkel, S., Agirre, E., Samudyata, Floriddia, E. M., Vanichkina, D. P., Ffrench-Constant, C., Williams, A., Guerreiro-Cacais, A. O., &Castelo-Branco, G. (2018). Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis. Nature Medicine, 24(12), 1837–1844.

Floriddia, E. M., &Castelo-Branco, G. (2019). Ancestry Tracing: Uncovering a Gliomagenesis Master Regulator. Cell Stem Cell, 24(5), 677–679.

Jäkel, S., Agirre, E., Mendanha Falcão, A., vanBruggen, D., Lee, K. W., Knuesel, I., Malhotra, D., Ffrench-Constant, C., Williams, A., &Castelo-Branco, G. (2019). Altered human oligodendrocyte heterogeneity in multiple sclerosis. Nature, 566(7745), 543–547.

Kupari, J., Häring, M., Agirre, E., Castelo-Branco, G., &Ernfors, P. (2019). An Atlas of Vagal Sensory Neurons and Their Molecular Specialization. Cell Reports, 27(8), 2508-2523.e4.

LaManno, G., Soldatov, R., Zeisel, A., Braun, E., Hochgerner, H., Petukhov, V., Lidschreiber, K., Kastriti, M. E., Lönnerberg, P., Furlan, A., Fan, J., Borm, L. E., Liu, Z., vanBruggen, D., Guo, J., He, X., Barker, R., Sundström, E., Castelo-Branco, G., …Kharchenko, P.V. (2018). RNA velocity of single cells. Nature, 560(7719), 494–498.

Marisca, R., Hoche, T., Agirre, E., Hoodless, L. J., Barkey, W., Auer, F., Castelo-Branco, G., &Czopka, T. (2020). Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Nature Neuroscience, 23(3), 363–374.

Marques, S., vanBruggen, D., &Castelo-Branco, G. (2019). Single-Cell RNA Sequencing of Oligodendrocyte Lineage Cells from the Mouse Central Nervous System. Methods in Molecular Biology (Clifton, N.J.), 1936, 1–21.

Marques, S., vanBruggen, D., Vanichkina, D. P., Floriddia, E. M., Munguba, H., Väremo, L., Giacomello, S., Falcão, A. M., Meijer, M., Björklund, Å. K., Hjerling-Leffler, J., Taft, R. J., &Castelo-Branco, G. (2018). Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development. Developmental Cell, 46(4), 504-517.e7.

Samudyata, Amaral, P. P., Engström, P. G., Robson, S. C., Nielsen, M. L., Kouzarides, T., &Castelo-Branco, G. (2019). Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells. Experimental Cell Research, 381(1), 129–138.

Samudyata, Castelo-Branco, G., &Bonetti, A. (2018). Birth, coming of age and death: The intriguing life of long noncoding RNAs. Seminars in Cell & Developmental Biology, 79, 143–152.

Samudyata, Castelo-Branco, G., &Liu, J. (2020). Epigenetic regulation of oligodendrocyte differentiation: From development to demyelinating disorders. GLIA, 68(8), 1619–1630.


Sijie Chen

Chen, S., Liu, J., Zhang, S., Zhao, E., Yu, C. Y. Y., Hushiarian, R., Hong, Y., &Tang, B. Z. (2018). Biochromic silole derivatives: a single dye for differentiation, quantitation and imaging of live/dead cells. Materials Horizons, 5(5), 969–978.

Gao, H., Kam, C., Chou, T. Y., Wu, M. Y., Zhao, X., &Chen, S. (2020). A simple yet effective AIE-based fluorescent nano-thermometer for temperature mapping in living cells using fluorescence lifetime imaging microscopy. Nanoscale Horizons, 5, 488–494.

Gao, H., Zhao, X., &Chen, S. (2018). AIEgen-Based Fluorescent Nanomaterials: Fabrication and Biological Applications. Molecules, 23(2), 419.

Gu, M., Zeng, Z., Wu, M. Y., Leung, J. K., Zhao, E., Wang, S., &Chen, S. (2019). Imaging Macrophage Phagocytosis Using AIE Luminogen-Labeled E. coli. Chemistry - An Asian Journal, 14(6), 775–780.

Hoffecker, I. T., Chen, S., Gådin, A., Bosco, A., Teixeira, A. I., &Högberg, B. (2019). Solution-Controlled Conformational Switching of an Anchored Wireframe DNA Nanostructure. Small (Weinheim an Der Bergstrasse, Germany), 15(1), e1803628.

Li, F., Han, J., Cao, T., Lam, W., Fan, B., Tang, W., Chen, S., Fok, K. L., &Li, L. (2019). Design of self-assembly dipeptide hydrogels and machine learning via their chemical features. Proceedings of the National Academy of Sciences of the United States of America, 116(23), 11259–11264.

Liu, L., Zou, Q., Leung, J. K., Wang, J. L., Kam, C., Chen, S., Feng, S., &Wu, M. Y. (2019). Ultrafast labeling and high-fidelity imaging of mitochondria in cancer cells using an aggregation-enhanced emission fluorescent probe. Chemical Communications, 55, 14681.

Tu, Y., Yu, Y., Zhou, Z., Xie, S., Yao, B., Guan, S., Situ, B., Liu, Y., Kwok, R. T. K., Lam, J. W. Y., Chen, S., Huang, X., Zeng, Z., &Tang, B. Z. (2019). Specific and Quantitative Detection of Albumin in Biological Fluids by Tetrazolate-Functionalized Water-Soluble AIEgens. ACS Applied Materials & Interfaces, 11(33), 29619–29629.

Wong, A. Y. H., Xie, S., Tang, B. Z., &Chen, S. (2019). Fluorescent Silver Staining of Proteins in Polyacrylamide Gels. Journal of Visualized Experiments : JoVE, 146.

Wu, M., Leung, J., Liu, L., Kam, C., Chan, K. Y. K., Li, R. A., Feng, S., &Chen, S. (2020). A Small‐Molecule AIE Chromosome Periphery Probe for Cytogenetic Studies. Angewandte Chemie International Edition, 59(26), 10327–10331.

Xie, S., Wong, A. Y. H., Chen, S., &Tang, B. Z. (2019). Fluorogenic Detection and Characterization of Proteins by Aggregation-Induced Emission Methods. Chemistry (Weinheim an Der Bergstrasse, Germany), 25(23), 5824–5847.

Xie, S., Wong, A. Y. H., Kwok, R. T. K., Li, Y., Su, H., Lam, J. W. Y., Chen, S., &Tang, B. Z. (2018). Fluorogenic Ag+–Tetrazolate Aggregation Enables Efficient Fluorescent Biological Silver Staining. Angewandte Chemie - International Edition, 57(20), 5750–5753.

Zhao, E., Lai, P., Xu, Y., Zhang, G., &Chen, S. (2020). Fluorescent Materials With Aggregation-Induced Emission Characteristics for Array-Based Sensing Assay. Frontiers in Chemistry, 8, 288.


Simon Elsässer

Kumar, B. and S. J. Elsasser (2019). Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells. Cell Rep 28(12): 3274-3284 e3275.

van Husen, L. S., S. Schedin-Weiss, M. N. Trung, M. Kazmi, B. Winblad, T. P. Sakmar, S. J. Elsässer and L. O. Tjernberg (2019). Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products. J. Alzheimer’s Dis. 72(2): [IN PRESS]. 

Meineke, B., J. Heimgartner, L. Lafranchi and S. J. Elsasser (2018). Methanomethylophilus alvus Mx1201 Provides Basis for Mutual Orthogonal Pyrrolysyl tRNA/Aminoacyl-tRNA Synthetase Pairs in Mammalian Cells. ACS Chem Biol 13(11): 3087-3096.


Christian Göritz

Dias, D. O. and C. Goritz (2018). Fibrotic scarring following lesions to the central nervous system. Matrix Biol 68-69: 561-570.

Dias, D. O., H. Kim, D. Holl, B. Werne Solnestam, J. Lundeberg, M. Carlen, C. Goritz and J. Frisen (2018). Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. Cell 173(1): 153-165 e122. 

Reichenbach, B., J. Classon, T. Aida, K. Tanaka, M. Genander and C. Goritz (2018). Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. EMBO J 37(9).2 8


Francois Lallemend

Bartesaghi, L., Wang, Y., Fontanet, P., Wanderoy, S., Berger, F., Wu, H., Akkuratova, N., Bouçanova, F., Médard, J. J., Petitpré, C., Landy, M. A., Zhang, M. D., Harrer, P., Stendel, C., Stucka, R., Dusl, M., Kastriti, M. E., Croci, L., Lai, H. C., …Chrast, R. (2019). PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis. Cell Reports, 26(13), 3484-3492.e4.

Faure, L., Wang, Y., Kastriti, M. E., Fontanet, P., Cheung, K. K. Y., Petitpré, C., Wu, H., Sun, L. L., Runge, K., Croci, L., Landy, M. A., Lai, H. C., Consalez, G. G., deChevigny, A., Lallemend, F., Adameyko, I., &Hadjab, S. (2020). Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates. Nature Communications, 11(1), 4175.

Furlan, A., Dyachuk, V., Kastriti, M. E., Calvo-Enrique, L., Abdo, H., Hadjab, S., Chontorotzea, T., Akkuratova, N., Usoskin, D., Kamenev, D., Petersen, J., Sunadome, K., Memic, F., Marklund, U., Fried, K., Topilko, P., Lallemend, F., Kharchenko, P.V., Ernfors, P., &Adameyko, I. (2017). Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. Science, 357, 6346.

Peng, C., Li, L., Zhang, M. D., Gonzales, C. B., Parisien, M., Belfer, I., Usoskin, D., Abdo, H., Furlan, A., Häring, M., Lallemend, F., Harkany, T., Diatchenko, L., Hökfelt, T., Hjerling-Leffler, J., &Ernfors, P. (2017). MIR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science, 356(6343), 1168–1171.

Petitpré, C., Wu, H., Sharma, A., Tokarska, A., Fontanet, P., Wang, Y., Helmbacher, F., Yackle, K., Silberberg, G., Hadjab, S., &Lallemend, F. (2018). Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nature Communications, 9(1), 3691.

Romanov, R. A., Tretiakov, E. O., Kastriti, M. E., Zupancic, M., Häring, M., Korchynska, S., Popadin, K., Benevento, M., Rebernik, P., Lallemend, F., Nishimori, K., Clotman, F., Andrews, W. D., Parnavelas, J. G., Farlik, M., Bock, C., Adameyko, I., Hökfelt, T., Keimpema, E., &Harkany, T. (2020). Molecular design of hypothalamus development. Nature, 582(7811), 246–252.

Wang, Y., Wu, H., Fontanet, P., Codeluppi, S., Akkuratova, N., Petitpré, C., Xue-Franzén, Y., Niederreither, K., Sharma, A., DaSilva, F., Comai, G., Agirman, G., Palumberi, D., Linnarsson, S., Adameyko, I., Moqrich, A., Schedl, A., LaManno, G., Hadjab, S., &Lallemend, F. (2019). A cell fitness selection model for neuronal survival during development. Nature Communications, 10(1), 4137.

Wang, Y., Wu, H., Zelenin, P., Fontanet, P., Wanderoy, S., Petitpré, C., Comai, G., Bellardita, C., Xue-Franzén, Y., Huettl, R. E., Huber, A. B., Tajbakhsh, S., Kiehn, O., Ernfors, P., Deliagina, T. G., Lallemend, F., &Hadjab, S. (2019). Muscle-selective RUNX3 dependence of sensorimotor circuit development. Development (Cambridge), 146(20).


Ning Xu Landén

Herter, E. K., Li, D., Toma, M. A., Vij, M., Li, X., Visscher, D., Wang, A., Chu, T., Sommar, P., Blomqvist, L., Berglund, D., Ståhle, M., Wikstrom, J. D., &Xu Landén, N. (2019). WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines. Journal of Investigative Dermatology, 139(6), 1373–1384.

Herter, E. K., &Xu Landén, N. (2017). Non-Coding RNAs: New Players in Skin Wound Healing. Advances in Wound Care, 6(3), 93–107.

Li, D., Kular, L., Vij, M., Herter, E. K., Li, X., Wang, A., Chu, T., Toma, M. A., Zhang, L., Liapi, E., Mota, A., Blomqvist, L., Sérézal, I. G., Rollman, O., Wikstrom, J. D., Bienko, M., Berglund, D., Ståhle, M., Sommar, P., …Landén, N. X. (2019). Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration. Proceedings of the National Academy of Sciences of the United States of America, 116(19), 9443–9452.

Li, D., &Landén, N. X. (2017). MicroRNAs in skin wound healing. European Journal of Dermatology : EJD, 27(S1), 12–14.

Li, X., Li, D., Wang, A., Chu, T., Lohcharoenkal, W., Zheng, X., Grünler, J., Narayanan, S., Eliasson, S., Herter, E. K., Wang, Y., Ma, Y., Ehrström, M., Eidsmo, L., Kasper, M., Pivarcsi, A., Sonkoly, E., Catrina, S. B., Ståhle, M., &Xu Landén, N. (2017). MicroRNA-132 with Therapeutic Potential in Chronic Wounds. Journal of Investigative Dermatology, 137(12), 2630–2638.

Li, X., Li, D., Wikstrom, J. D., Pivarcsi, A., Sonkoly, E., Ståhle, M., &Landén, N. X. (2017). MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing. Scientific Reports, 7(1), 7797.

Li D, Peng H, Qu L, Sommar P, Wang A, Chu T, Li X, Bi X, Liu Q, Sérézal IG, Rollman O, Lohcharoenkal W, Zheng X, Angelstig SE, Grünler J, Pivarcsi A, Sonkoly E, Catrina S-B, Xiao C, Ståhle M, Mi Q-S, Zhou L&Landén, N. X. (2020).  miR-19a/b and miR-20a promote wound healing by regulating the inflammatory response of keratinocytes. Journal of Investigative Dermatology (Accepted on June 29th, 2020).

Wang, A., Toma, M. A., Ma, J., Li, D., Vij, M., Chu, T., Wang, J., Li, X., &Xu Landén, N. (2020). Circular RNA hsa-circ-0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation. Advances in Wound Care, 9(4), 145–160.

Wu, J., &Landén, N. X. (2020). Investigation of Skin Wound Healing Using a Mouse Model. Methods in Molecular Biology (Clifton, N.J.), 2154, 239–247.

Wu, J., Li, X., Li, D., Ren, X., Li, Y., Herter, E. K., Qian, M., Toma, M. A., Wintler, A. M., Sérézal, I. G., Rollman, O., Ståhle, M., Wikstrom, J. D., Ye, X., &Landén, N. X. (2020). MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4. Journal of Investigative Dermatology, 140(2), 465–476.


Fredrik Lanner

Collier, A. J., Panula, S. P., Schell, J. P., Chovanec, P., Plaza Reyes, A., Petropoulos, S., Corcoran, A. E., Walker, R., Douagi, I., Lanner, F., &Rugg-Gunn, P. J. (2017). Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States. Cell Stem Cell, 20(6), 874–890.

Gelali, E., Girelli, G., Matsumoto, M., Wernersson, E., Custodio, J., Mota, A., Schweitzer, M., Ferenc, K., Li, X., Mirzazadeh, R., Agostini, F., Schell, J. P., Lanner, F., Crosetto, N., &Bienko, M. (2019). iFISH is a publically available resource enabling versatile DNA FISH to study genome architecture. Nature Communications, 10(1), 1636.

Hildebrand, S., Hultin, S., Subramani, A., Petropoulos, S., Zhang, Y., Cao, X., Mpindi, J., Kalloniemi, O., Johansson, S., Majumdar, A., Lanner, F., &Holmgren, L. (2017). The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Scientific Reports, 7(1), 9540.

Nosi, U., Lanner, F., Huang, T., &Cox, B. (2017). Overexpression of Trophoblast Stem Cell-Enriched MicroRNAs Promotes Trophoblast Fate in Embryonic Stem Cells. Cell Reports, 19(6), 1101–1109.

Ortega, N. M., Winblad, N., Plaza Reyes, A., &Lanner, F. (2018). Functional genetics of early human development. Current Opinion in Genetics and Development, 52, 1–6.

Petrus-Reurer, S., Bartuma, H., Aronsson, M., Westman, S., Lanner, F., André, H., &Kvanta, A. (2017). Integration of subretinal suspension transplants of human embryonic stem cell-derived retinal pigment epithelial cells in a large-eyed model of geographic atrophy. Investigative Ophthalmology and Visual Science, 58(2), 1314–1322.

Petrus-Reurer, S., Bartuma, H., Aronsson, M., Westman, S., Lanner, F., &Kvanta, A. (2018). Subretinal transplantation of human embryonic stem cell derived-retinal pigment epithelial cells into a large-eyed model of geographic atrophy. Journal of Visualized Experiments, 131.

Petrus-Reurer, S., Kumar, P., Padrell Sánchez, S., Aronsson, M., André, H., Bartuma, H., Plaza Reyes, A., Nandrot, E. F., Kvanta, A., &Lanner, F. (2020). Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration. Stem Cells Translational Medicine, 9(8), 936–953.

Petrus-Reurer, S., Winblad, N., Kumar, P., Gorchs, L., Chrobok, M., Wagner, A. K., Bartuma, H., Lardner, E., Aronsson, M., Plaza Reyes, Á., André, H., Alici, E., Kaipe, H., Kvanta, A., &Lanner, F. (2020). Generation of Retinal Pigment Epithelial Cells Derived from Human Embryonic Stem Cells Lacking Human Leukocyte Antigen Class I and II. Stem Cell Reports, 14(4), 648–662.

Plaza Reyes, A., &Lanner, F. (2018). Time Matters: Gene Editing at the Mouse 2-Cell Embryo Stage Boosts Knockin Efficiency. Cell Stem Cell, 23(2), 155–157.

Plaza Reyes, A., Petrus-Reurer, S., Padrell Sánchez, S., Kumar, P., Douagi, I., Bartuma, H., Aronsson, M., Westman, S., Lardner, E., André, H., Falk, A., Nandrot, E. F., Kvanta, A., &Lanner, F. (2020). Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells. Nature Communications, 11, 1609.

Posfai, E., Petropoulos, S., deBarros, F. R. O., Schell, J. P., Jurisica, I., Sandberg, R., Lanner, F., &Rossant, J. (2017). Position- and hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo. ELife, 6.

Reyes, A. P., &Lanner, F. (2017). Towards a CRISPR view of early human development: Applications, limitations and ethical concerns of genome editing in human embryos. Development (Cambridge), 144, 3–7.

Wagner, M., Yoshihara, M., Douagi, I., Damdimopoulos, A., Panula, S., Petropoulos, S., Lu, H., Pettersson, K., Palm, K., Katayama, S., Hovatta, O., Kere, J., Lanner, F., &Damdimopoulou, P. (2020). Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells. Nature Communications, 11(1), 1147.

Wagner, M., Yoshihara, M., Douagi, I., Damdimopoulos, A., Panula, S., Petropoulos, S., Lu, H., Pettersson, K., Palm, K., Katayama, S., Hovatta, O., Kere, J., Lanner, F., &Damdimopoulou, P. (2019). Single cell map of the human ovarian cortex. BioRxiv.

Winblad, N., &Lanner, F. (2017). Biotechnology: At the heart of gene edits in human embryos. Nature, 548(7668), 398–400.


Linxian Li

Guo, J. C., D. H. Wang, Q. Q. Sun, L. X. Li, H. X. Zhao, D. S. Wang, J. X. Cui, L. Q. Chen and X. Deng (2019). Omni-Liquid Droplet Manipulation Platform. Advanced Materials Interfaces 6(16). 

Miao, L., L. Li, Y. Huang, D. Delcassian, J. Chahal, J. Han, Y. Shi, K. Sadtler, W. Gao, J. Lin, J. C. Doloff, R. Langer and D. G. Anderson (2019). Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nat Biotechnol.2 9

Yang, C., G. He, A. Zhang, Q. Wu, L. Zhou, T. Hang, D. Liu, S. Xiao, H. J. Chen, F. Liu, L. Li, J. Wang and X. Xie (2019). Injectable Slippery Lubricant-Coated Spiky Microparticles with Persistent and Exceptional Biofouling-Resistance. ACS Cent Sci 5(2): 250-258.

Yang, J., D. Wang, H. Liu, L. Li, L. Chen, H. R. Jiang and X. Deng (2019). An electric-field-dependent drop selector. Lab Chip 19(7): 1296-1304.


Ronald Li

Chow, M. Z., S. N. Sadrian, W. Keung, L. Geng, L. Ren, C. W. Kong, A. O. Wong, J. S. Hulot, C. S. Chen, K. D. Costa, R. J. Hajjar and R. A. Li (2019). Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues. Sci Rep 9(1): 7502.

Keung, W., P. K. W. Chan, P. C. Backeris, E. K. Lee, N. Wong, A. O. T. Wong, G. K. Y. Wong, C. W. Y. Chan, B. Fermini, K. D. Costa and R. A. Li (2019). Human Cardiac Ventricular- Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses. Clin Pharmacol Ther.

Li, S., W. Keung, H. Cheng and R. A. Li (2019). Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes. Stem Cells Int 2019: 8765752.

Ceholski, D. K., I. C. Turnbull, C. W. Kong, S. Koplev, J. Mayourian, P. A. Gorski, F. Stillitano, A. A. Skodras, M. Nonnenmacher, N. Cohen, J. L. M. Bjorkegren, D. R. Stroik, R. L. Cornea, D. D. Thomas, R. A. Li, K. D. Costa and R. J. Hajjar (2018). Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol 119: 147-154.

Foo, K. S., M. L. Lehtinen, C. Y. Leung, X. Lian, J. Xu, W. Keung, L. Geng, T. R. S. Kolstad, S. Thams, A. O. Wong, N. Wong, K. Bylund, C. Zhou, X. He, S. B. Jin, J. Clarke, U. Lendahl, R. A. Li, W. E. Louch and K. R. Chien (2018). Human ISL1(+) Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther 26(7): 1644-1659. 

Geng, L., C. W. Kong, A. O. T. Wong, A. M. Shum, M. Z. Y. Chow, H. Che, C. Zhang, K. L. Yau, C. W. Chan, W. Keung and R. A. Li (2018). Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers. Toxicol Lett 294: 61-72.

Kong, C. W., L. Geng and R. A. Li (2018). High-Content Electrophysiological Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes (hPSC-CMs). Methods Mol Biol 1722: 185-194. 

Li, R. A., W. Keung, T. J. Cashman, P. C. Backeris, B. V. Johnson, E. S. Bardot, A. O. T. Wong, P. K. W. Chan, C. W. Y. Chan and K. D. Costa (2018). Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells. Biomaterials 163: 116-127. 

Li, Z., Z. Meng, J. Lu, F. M. Chen, W. T. Wong, G. Tse, C. Zheng, W. Keung, K. Tse, R. A. Li, L. Jiang and X. Yao (2018). TRPV6 protects ER stress-induced apoptosis via ATF6alpha- TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes. J Mol Cell Cardiol 120: 1-11. 

Lu, J., K. R. Boheler, L. Jiang, C. W. Chan, W. W. Tse, W. Keung, E. N. Poon, R. A. Li and X. Yao (2018). Polycystin-2 Plays an Essential Role in Glucose Starvation-Induced Autophagy in Human Embryonic Stem Cell-Derived Cardiomyocytes. Stem Cells 36(4): 501-513. 


Zongli Zheng

Choi, G. C. G., P. Zhou, C. T. L. Yuen, B. K. C. Chan, F. Xu, S. Bao, H. Y. Chu, D. Thean, K. Tan, K. H. Wong, Z. Zheng and A. S. L. Wong (2019). Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9. Nat Methods 16(8): 722-730. 

Tan, Y., A. H. Y. Chu, S. Bao, D. A. Hoang, F. T. Kebede, W. Xiong, M. Ji, J. Shi and Z. Zheng (2019). Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity. Proc Natl Acad Sci U S A.