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MWLC Publications

The publications from Ming Wai Lau Centre for Reparative Medicine reflect collaborative efforts both within and outside of KI. The selected publications are sorted by researchers.

Gonçalo Castelo-Branco

Falcao, A. M., M. Meijer, A. Scaglione, P. Rinwa, E. Agirre, J. Liang, S. C. Larsen, A. Heskol, R. Frawley, M. Klingener, M. Varas-Godoy, A. Raposo, P. Ernfors, D. S. Castro, M. L. Nielsen, P. Casaccia and G. Castelo-Branco (2019). PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Rep 27(4): 1090-1102 e1010. 

Floriddia, E. M. and G. Castelo-Branco (2019). Ancestry Tracing: Uncovering a Gliomagenesis Master Regulator. Cell Stem Cell 24(5): 677-679. 

Jakel, S., E. Agirre, A. Mendanha Falcao, D. van Bruggen, K. W. Lee, I. Knuesel, D. Malhotra, C. Ffrench-Constant, A. Williams and G. Castelo-Branco (2019). Altered human oligodendrocyte heterogeneity in multiple sclerosis. Nature 566(7745): 543-547. 

 Kupari, J., M. Haring, E. Agirre, G. Castelo-Branco and P. Ernfors (2019). An Atlas of Vagal Sensory Neurons and Their Molecular Specialization. Cell Rep 27(8): 2508-2523 e2504.

Marques, S., D. van Bruggen and G. Castelo-Branco (2019). Single-Cell RNA Sequencing of Oligodendrocyte Lineage Cells from the Mouse Central Nervous System. Methods Mol Biol 1936: 1-21. 

Samudyata, P. P. Amaral, P. G. Engstrom, S. C. Robson, M. L. Nielsen, T. Kouzarides and G. Castelo-Branco (2019). Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells. Exp Cell Res 381(1): 129- 138.

Falcao, A. M., D. van Bruggen, S. Marques, M. Meijer, S. Jakel, E. Agirre, Samudyata, E. M. Floriddia, D. P. Vanichkina, C. Ffrench-Constant, A. Williams, A. O. Guerreiro- Cacais and G. Castelo-Branco (2018). Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis. Nat Med 24(12): 1837-1844.

La Manno, G., R. Soldatov, A. Zeisel, E. Braun, H. Hochgerner, V. Petukhov, K. Lidschreiber, M. E. Kastriti, P. Lonnerberg, A. Furlan, J. Fan, L. E. Borm, Z. Liu, D. van Bruggen, J. Guo, X. He, R. Barker, E. Sundstrom, G. Castelo-Branco, P. Cramer, I. Adameyko, S. Linnarsson and P. V. Kharchenko (2018). RNA velocity of single cells. Nature 560(7719): 494-498.

Marques, S., D. van Bruggen, D. P. Vanichkina, E. M. Floriddia, H. Munguba, L. Varemo, S. Giacomello, A. M. Falcao, M. Meijer, A. K. Bjorklund, J. Hjerling-Leffler, R. J. Taft and G. Castelo-Branco (2018). Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development. Dev Cell 46(4): 504-517 e507.

Samudyata, G. Castelo-Branco and A. Bonetti (2018). Birth, coming of age and death: The intriguing life of long noncoding RNAs. Semin Cell Dev Biol 79: 143-152.


Sijie Chen

Wu, M., J. Leung, L. Liu, C. Kam, K. Y. K. Chan, R. A. Li, S. Feng, S. Chen (2020). A Small Molecule AIE Chromosome Periphery Probe for Cytogenetic Studies. Angewandte Chemie International Edition.

Gao, H., C. Kam, T. Y. Chou, M.-Y. Wu, X. Zhao and S. Chen (2020). A simple yet effective AIE-based fluorescent nano-thermometer for temperature mapping in living cells using fluorescence lifetime imaging microscopy. Nanoscale Horizons 5: 488.!divAbstract

Liu, L., Q. Zou, J. Leung, J. Wang, C. Kam, S. Chen, S. Feng and M. Wu (2019). Ultrafast labeling and high-fidelity imaging of mitochondria in cancer cells using an aggregation-enhanced emission fluorescent probe. Chemical Communications 55: 14681.

Gu, M., Z. Zeng, M. Y. Wu, J. K. Leung, E. Zhao, S. Wang and S. Chen (2019). Imaging Macrophage Phagocytosis Using AIE Luminogen-Labeled E. coli. Chem Asian J 14(6): 775- 780. 

Hoffecker, I. T., S. Chen, A. Gadin, A. Bosco, A. I. Teixeira and B. Hogberg (2019). Solution-Controlled Conformational Switching of an Anchored Wireframe DNA Nanostructure. Small 15(1): e1803628.

Li, F., J. Han, T. Cao, W. Lam, B. Fan, W. Tang, S. Chen, K. L. Fok and L. Li (2019). Design of self-assembly dipeptide hydrogels and machine learning via their chemical features. Proc Natl Acad Sci U S A 116(23): 11259-11264. 

Tu, Y., Y. Yu, Z. Zhou, S. Xie, B. Yao, S. Guan, B. Situ, Y. Liu, R. T. K. Kwok, J. W. Y. Lam, S. Chen, X. Huang, Z. Zeng and B. Z. Tang (2019). Specific and Quantitative Detection of Albumin in Biological Fluids by Tetrazolate-Functionalized Water-Soluble AIEgens. ACS Appl Mater Interfaces 11(33): 29619-29629. 

Wong, A. Y. H., S. Xie, B. Z. Tang and S. Chen (2019). Fluorescent Silver Staining of Proteins in Polyacrylamide Gels. J Vis Exp(146).

Xie, S., A. Y. H. Wong, S. Chen and B. Z. Tang (2019). Fluorogenic Detection and Characterization of Proteins by Aggregation-Induced Emission Methods. Chem.: Eur. J. 25(23): 5824-5847.

Chen, S. J., J. Z. Liu, S. X. Zhang, E. G. Zhao, C. Y. Y. Yu, R. Hushiarian, Y. N. Hong and B. Z. Tang (2018). Biochromic silole derivatives: a single dye for differentiation, quantitation and imaging of live/dead cells. Materials Horizons 5(5): 969-978.

Gao, H., X. Zhao and S. Chen (2018). AIEgen-Based Fluorescent Nanomaterials: Fabrication and Biological Applications. Molecules 23(2).

Xie, S., A. Y. H. Wong, R. T. K. Kwok, Y. Li, H. Su, J. W. Y. Lam, S. Chen and B. Z. Tang (2018). Fluorogenic Ag+–Tetrazolate Aggregation Enables Efficient Fluorescent Biological Silver Staining. Angew Chem Int Ed Engl 57(20): 5750-5753. 


Simon Elsässer

Kumar, B. and S. J. Elsasser (2019). Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells. Cell Rep 28(12): 3274-3284 e3275.

van Husen, L. S., S. Schedin-Weiss, M. N. Trung, M. Kazmi, B. Winblad, T. P. Sakmar, S. J. Elsässer and L. O. Tjernberg (2019). Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products. J. Alzheimer’s Dis. 72(2): [IN PRESS]. 

Meineke, B., J. Heimgartner, L. Lafranchi and S. J. Elsasser (2018). Methanomethylophilus alvus Mx1201 Provides Basis for Mutual Orthogonal Pyrrolysyl tRNA/Aminoacyl-tRNA Synthetase Pairs in Mammalian Cells. ACS Chem Biol 13(11): 3087-3096.


Christian Göritz

Dias, D. O. and C. Goritz (2018). Fibrotic scarring following lesions to the central nervous system. Matrix Biol 68-69: 561-570.

Dias, D. O., H. Kim, D. Holl, B. Werne Solnestam, J. Lundeberg, M. Carlen, C. Goritz and J. Frisen (2018). Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. Cell 173(1): 153-165 e122. 

Reichenbach, B., J. Classon, T. Aida, K. Tanaka, M. Genander and C. Goritz (2018). Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. EMBO J 37(9).2 8


Francois Lallemend

Bartesaghi, L., Y. Wang, P. Fontanet, S. Wanderoy, F. Berger, H. Wu, N. Akkuratova, F. Boucanova, J. J. Medard, C. Petitpre, M. A. Landy, M. D. Zhang, P. Harrer, C. Stendel, R. Stucka, M. Dusl, M. E. Kastriti, L. Croci, H. C. Lai, G. G. Consalez, A. Pattyn, P. Ernfors, J. Senderek, I. Adameyko, F. Lallemend, S. Hadjab and R. Chrast (2019). PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis. Cell Rep 26(13): 3484-3492 e3484. 

Petitpre, C., H. Wu, A. Sharma, A. Tokarska, P. Fontanet, Y. Wang, F. Helmbacher, K. Yackle, G. Silberberg, S. Hadjab and F. Lallemend (2018). Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nat Commun 9(1): 3691.


Ning Xu Landén

Herter, E. K., D. Li, M. A. Toma, M. Vij, X. Li, D. Visscher, A. Wang, T. Chu, P. Sommar, L. Blomqvist, D. Berglund, M. Stahle, J. D. Wikstrom and N. Xu Landen (2019). WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines. J Invest Dermatol 139(6): 1373-1384.

Li, D., L. Kular, M. Vij, E. K. Herter, X. Li, A. Wang, T. Chu, M. A. Toma, L. Zhang, E. Liapi, A. Mota, L. Blomqvist, I. G. Serezal, O. Rollman, J. D. Wikstrom, M. Bienko, D. Berglund, M. Stahle, P. Sommar, M. Jagodic and N. X. Landen (2019). Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration. Proc Natl Acad Sci U S A 116(19): 9443-9452.

Wang, A. X., M. A. Toma, J. X. Ma, D. Q. Li, M. Vij, T. B. Chu, J. Wang, X. Li and N. X. Landen (2019). Circular RNA hsa_ circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation. Advances in Wound Care.

Wu, J., X. Li, D. Li, X. Ren, Y. Li, E. K. Herter, M. Qian, M. A. Toma, A. M. Wintler, I. G. Serezal, O. Rollman, M. Stahle, J. D. Wikstrom, X. Ye and N. X. Landen (2019). MicroRNA-34 family enhances wound inflammation by targeting LGR4. J Invest Dermatol.


Fredrik Lanner

Wagner, M., M. Yoshihara, I. Douagi, A. Damdimopoulos, S. Panula, S. Petropoulos, H. Lu, K. Pettersson, K. Palm, S. Katayama, O. Hovatta, J. Kere, F. Lanner and P. Damdimopoulou (2020). Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells. Nat Commun 11: 1147.

Gelali, E., G. Girelli, M. Matsumoto, E. Wernersson, J. Custodio, A. Mota, M. Schweitzer, K. Ferenc, X. Li, R. Mirzazadeh, F. Agostini, J. P. Schell, F. Lanner, N. Crosetto and M. Bienko (2019). iFISH is a publically available resource enabling versatile DNA FISH to study genome architecture. Nat Commun 10(1): 1636.

Wagner, M., M. Yoshihara, I. Douagi, A. Damdimopoulos, S. Panula, S. Petropoulos, H. Lu, K. Pettersson, K. Palm, S. Katayama, O. Hovatta, J. Kere, F. Lanner and P. Damdimopoulou (2019). Single cell map of the human ovarian cortex. bioRxiv.

Ortega, N. M., N. Winblad, A. Plaza Reyes and F. Lanner (2018). Functional genetics of early human development. Curr Opin Genet Dev 52: 1-6.

Petrus-Reurer, S., H. Bartuma, M. Aronsson, S. Westman, F. Lanner and A. Kvanta (2018). Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy. J Vis Exp(131).

Plaza Reyes, A. and F. Lanner (2018). Time Matters: Gene Editing at the Mouse 2-Cell Embryo Stage Boosts Knockin Efficiency. Cell Stem Cell 23(2): 155-157. 

Collier, A. J., S. P. Panula, J. P. Schell, P. Chovanec, A. Plaza Reyes, S. Petropoulos, A. E. Corcoran, R. Walker, I. Douagi, F. Lanner and P. J. Rugg-Gunn (2017). Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States. Cell Stem Cell 20(6): 874-890 e877.

Hildebrand, S., S. Hultin, A. Subramani, S. Petropoulos, Y. Zhang, X. Cao, J. Mpindi, O. Kalloniemi, S. Johansson, A. Majumdar, F. Lanner and L. Holmgren (2017). The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Sci Rep 7(1): 9540.

Nosi, U., F. Lanner, T. Huang and B. Cox (2017). Overexpression of Trophoblast Stem Cell-Enriched MicroRNAs Promotes Trophoblast Fate in Embryonic Stem Cells. Cell Rep 19(6): 1101-1109.

Petrus-Reurer, S., H. Bartuma, M. Aronsson, S. Westman, F. Lanner, H. Andre and A. Kvanta (2017). Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy. Invest Ophthalmol Vis Sci 58(2): 1314-1322.

Posfai, E., S. Petropoulos, F. R. O. de Barros, J. P. Schell, I. Jurisica, R. Sandberg, F. Lanner and J. Rossant (2017). Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo. Elife 6.

Reyes, A. P. and F. Lanner (2017).Towards a CRISPR view of early human development: Applications, limitations and ethical concerns of genome editing in human embryos. Development (Cambridge) 144: 3-7.

Winblad, N. and F. Lanner (2017). Biotechnology: At the heart of gene edits in human embryos. Nature 548(7668): 398-400.


Linxian Li

Guo, J. C., D. H. Wang, Q. Q. Sun, L. X. Li, H. X. Zhao, D. S. Wang, J. X. Cui, L. Q. Chen and X. Deng (2019). Omni-Liquid Droplet Manipulation Platform. Advanced Materials Interfaces 6(16). 

Miao, L., L. Li, Y. Huang, D. Delcassian, J. Chahal, J. Han, Y. Shi, K. Sadtler, W. Gao, J. Lin, J. C. Doloff, R. Langer and D. G. Anderson (2019). Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nat Biotechnol.2 9

Yang, C., G. He, A. Zhang, Q. Wu, L. Zhou, T. Hang, D. Liu, S. Xiao, H. J. Chen, F. Liu, L. Li, J. Wang and X. Xie (2019). Injectable Slippery Lubricant-Coated Spiky Microparticles with Persistent and Exceptional Biofouling-Resistance. ACS Cent Sci 5(2): 250-258.

Yang, J., D. Wang, H. Liu, L. Li, L. Chen, H. R. Jiang and X. Deng (2019). An electric-field-dependent drop selector. Lab Chip 19(7): 1296-1304.

Ronald Li

Chow, M. Z., S. N. Sadrian, W. Keung, L. Geng, L. Ren, C. W. Kong, A. O. Wong, J. S. Hulot, C. S. Chen, K. D. Costa, R. J. Hajjar and R. A. Li (2019). Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues. Sci Rep 9(1): 7502.

Keung, W., P. K. W. Chan, P. C. Backeris, E. K. Lee, N. Wong, A. O. T. Wong, G. K. Y. Wong, C. W. Y. Chan, B. Fermini, K. D. Costa and R. A. Li (2019). Human Cardiac Ventricular- Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses. Clin Pharmacol Ther.

Li, S., W. Keung, H. Cheng and R. A. Li (2019). Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes. Stem Cells Int 2019: 8765752.

Ceholski, D. K., I. C. Turnbull, C. W. Kong, S. Koplev, J. Mayourian, P. A. Gorski, F. Stillitano, A. A. Skodras, M. Nonnenmacher, N. Cohen, J. L. M. Bjorkegren, D. R. Stroik, R. L. Cornea, D. D. Thomas, R. A. Li, K. D. Costa and R. J. Hajjar (2018). Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol 119: 147-154.

Foo, K. S., M. L. Lehtinen, C. Y. Leung, X. Lian, J. Xu, W. Keung, L. Geng, T. R. S. Kolstad, S. Thams, A. O. Wong, N. Wong, K. Bylund, C. Zhou, X. He, S. B. Jin, J. Clarke, U. Lendahl, R. A. Li, W. E. Louch and K. R. Chien (2018). Human ISL1(+) Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther 26(7): 1644-1659. 

Geng, L., C. W. Kong, A. O. T. Wong, A. M. Shum, M. Z. Y. Chow, H. Che, C. Zhang, K. L. Yau, C. W. Chan, W. Keung and R. A. Li (2018). Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers. Toxicol Lett 294: 61-72.

Kong, C. W., L. Geng and R. A. Li (2018). High-Content Electrophysiological Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes (hPSC-CMs). Methods Mol Biol 1722: 185-194. 

Li, R. A., W. Keung, T. J. Cashman, P. C. Backeris, B. V. Johnson, E. S. Bardot, A. O. T. Wong, P. K. W. Chan, C. W. Y. Chan and K. D. Costa (2018). Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells. Biomaterials 163: 116-127. 

Li, Z., Z. Meng, J. Lu, F. M. Chen, W. T. Wong, G. Tse, C. Zheng, W. Keung, K. Tse, R. A. Li, L. Jiang and X. Yao (2018). TRPV6 protects ER stress-induced apoptosis via ATF6alpha- TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes. J Mol Cell Cardiol 120: 1-11. 

Lu, J., K. R. Boheler, L. Jiang, C. W. Chan, W. W. Tse, W. Keung, E. N. Poon, R. A. Li and X. Yao (2018). Polycystin-2 Plays an Essential Role in Glucose Starvation-Induced Autophagy in Human Embryonic Stem Cell-Derived Cardiomyocytes. Stem Cells 36(4): 501-513. 


Zongli Zheng

Choi, G. C. G., P. Zhou, C. T. L. Yuen, B. K. C. Chan, F. Xu, S. Bao, H. Y. Chu, D. Thean, K. Tan, K. H. Wong, Z. Zheng and A. S. L. Wong (2019). Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9. Nat Methods 16(8): 722-730. 

Tan, Y., A. H. Y. Chu, S. Bao, D. A. Hoang, F. T. Kebede, W. Xiong, M. Ji, J. Shi and Z. Zheng (2019). Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity. Proc Natl Acad Sci U S A.