Skip to main content

Sijie Chen

Dr. Sijie Chen is an Assistant Professor at Ming Wai Lau Centre for Reparative Medicine, KI, in Hong Kong.

Dr. Sijie Chen


Dr. Sijie Chen's current research interests focus on the development of new luminescent materials and novel methods for studying the biological events, especially fluorescent tools for mechanobiology research.


Dr. Sijie Chen received her BSc in Biology from Wuhan University in 2009 and PhD in Bioengineering from Hong Kong University of Science and Technology (HKUST) in 2013, under the supervision of Prof Ben Zhong Tang. She worked as a Postdoctoral Fellow in HKUST and then as an Endeavour Fellow in University of Melbourne and a visiting scientist in Walter and Eliza Hall Institute of Medical Research. She joined Prof Ana Teixeira’s group as a Postdoc in the Division of Biomaterials and Regenerative Medicine at the Department of Medical Biochemistry and Biophysics in Karolinska Institutet (KI) since late 2015.

She was earlier working on fluorescent biosensors, fluorescence imaging and nanomaterials. She has authored and co-authored ~ 50 scientific papers in related areas.

Group Members

Name Title/Position
Sijie Chen Assistant Professor
Blake Ho Postdoctoral Researcher
Mingyu Wu Postdoctoral Researcher
Yupeng Shi Postdoctoral Researcher
Chuen Kam Research Officer
Renee Chou Research Assistant
Chloe Lee Research Assistant
Miller Leung Research Assistant
Alex Wong PhD Student

Previous lab members

  • Dr Hui Gao, 2017-2019; Ph.D., Queen Mary University of London, UK; before join KI: The University of Leeds. Recipient of Thousand Young Talents Program (2018). 2019-now, Professor, Beihang University. 
  • Dr Fei Li,  2017-2019, Co-supervised with Dr Linxian Li, MWLC, KI; Ph.D., Nanjing University, China. 2019-now, Associate Professor, China Pharmaceutical University.   
  • Dr Sheng Xie, 2017-2019; Ph.D., Royal Institute of Technology, Sweden; before join KI: HKUST. Recipient of International Postdoc Grant (2018-2019). 2020-now, Professor, Hunan University. 

Selected Publications

M. Wu, J. Leung, L. Liu, C. Kam, K. Y. K. Chan, R. A. Li, S. Feng, S. Chen*. “A Small Molecule AIE Chromosome Periphery Probe for Cytogenetic Studies.” Angewandte Chemie International Edition, (2020).

H. Gao, C. Kam, T. Y. Chou, M.-Y. Wu, X. Zhao, S. Chen. "A simple yet effective AIE-based fluorescent nano-thermometer for temperature mapping in living cells using fluorescence lifetime imaging microscopy." Nanoscale Horizons., 2020, 5, 488.!divAbstract

S. Xie, A.Y.H. Wong, R.T.K. Kwok, Y. Li, H. Su, J.W.Y. Lam, S. Chen*, B.Z. Tang*. "Fluorogenic Ag+–Tetrazolate Aggregation Enables Efficient Fluorescent Biological Silver Staining." Angew. Chem. Int. Ed., 2018, 57, 5750.

B. Situ#, S. Chen#, E. Zhao, C. W. T. Leung, Y. Chen, Y. Hong, J. W. Y. Lam, Z. Wen, W. Liu, W. Zhang, L. Zheng, B. Z. Tang. “Real-Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria Targeting AIE Fluorogen.” Adv. Funct. Mater., 2016, 26, 7132.

S. Chen, Y. Hong, Y. Liu, J. Liu, C. W. T. Leung, M. Li, R. T. K. Kwok, E. Zhao, J. W. Y. Lam, Y. Yu, B. Z. Tang. “Full-Range Intracellular pH Sensing by an Aggregation-Induced Emission-Active Two-Channel Ratiometric Fluorogen.” J. Am. Chem. Soc., 2013, 135, 4926.

S. Chen#, J. Liu#, Y. Liu, H. Su, Y. Hong, C. K. W. Jim, R. T. K. Kwok, N. Zhao, W. Qin, J.W.Y Lam, K. S. Wong, B. Z. Tang. “An AIE-active hemicyanine fluorogen with stimuli-responsive red/blue emission: extending the pH sensing range by “switch + knob” effect.” Chem. Sci., 2012, 3, 1804.

# co-first author; * corresponding author