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Sijie Chen

Dr. Sijie Chen is an Assistant Professor at Ming Wai Lau Centre for Reparative Medicine, KI, in Hong Kong.


Dr. Sijie Chen's current research interests focus on the development of new luminescent materials and novel methods for studying the biological events, especially fluorescent tools for mechanobiology research.


Dr. Sijie Chen received her BSc in Biology from Wuhan University in 2009 and PhD in Bioengineering from Hong Kong University of Science and Technology (HKUST) in 2013, under the supervision of Prof Ben Zhong Tang. She worked as a Postdoctoral Fellow in HKUST and then as an Endeavour Fellow in University of Melbourne and a visiting scientist in Walter and Eliza Hall Institute of Medical Research. She joined Prof Ana Teixeira’s group as a Postdoc in the Division of Biomaterials and Regenerative Medicine at the Department of Medical Biochemistry and Biophysics in Karolinska Institutet (KI) since late 2015.

She was earlier working on fluorescent biosensors, fluorescence imaging and nanomaterials. She has authored and co-authored ~ 40 scientific papers in related areas.

Group members

Name Title/Position
Sijie Chen Assistant Professor
Renee Chou Research Assistant
Blake Ho Postdoc
Chuen Kam Research Officer
Chloe Lee Research Assistant
Miller Leung Research Assistant
Alex Wong Research Assistant
Mingyu Wu Postdoc
Sheng Xie Postdoc

Previous lab members

Hui Gao

Sijie Chen's latest publication

Selected publications

S. Xie , A.Y.H. Wong, R.T.K. Kwok, Y. Li, H. Su, J.W.Y. Lam, S. Chen*, B.Z. Tang*. "Fluorogenic Ag+–Tetrazolate Aggregation Enables Efficient Fluorescent Biological Silver Staining." Angew. Chem. Int. Ed., 2018, 57, 5750.

B. Situ#, S. Chen#, E. Zhao, C. W. T. Leung, Y. Chen, Y. Hong, J. W. Y. Lam, Z. Wen, W. Liu, W. Zhang, L. Zheng, B. Z. Tang. “Real-Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria Targeting AIE Fluorogen.” Adv. Funct. Mater., 2016, 26, 7132.

S. Chen, Y. Hong, Y. Liu, J. Liu, C. W. T. Leung, M. Li, R. T. K. Kwok, E. Zhao, J. W. Y. Lam, Y. Yu, B. Z. Tang. “Full-Range Intracellular pH Sensing by an Aggregation-Induced Emission-Active Two-Channel Ratiometric Fluorogen.” J. Am. Chem. Soc., 2013, 135, 4926.

S. Chen#, J. Liu#, Y. Liu, H. Su, Y. Hong, C. K. W. Jim, R. T. K. Kwok, N. Zhao, W. Qin, J.W.Y Lam, K. S. Wong, B. Z. Tang. “An AIE-active hemicyanine fluorogen with stimuli-responsive red/blue emission: extending the pH sensing range by “switch + knob” effect.” Chem. Sci., 2012, 3, 1804.

# co-first author; * corresponding author