Schlisio lab - Selected publications

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.
Li S, Li W, Yuan J, Bullova P, Wu J, Zhang X, Liu Y, Plescher M, Rodriguez J, Bedoya-Reina OC, Jannig PR, Valente-Silva P, Yu M, Henriksson MA, Zubarev RA, Smed-Sörensen A, Suzuki CK, Ruas JL, Holmberg J, Larsson C, Christofer Juhlin C, von Kriegsheim A, Cao Y, Schlisio S
Nat Metab 2022 06;4(6):739-758

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.
Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko I, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S.
Nat Commun. 2021 Sep 7;12(1):5309. doi: 10.1038/s41467-021-24870-7.

Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.
Shi Y, Yuan J, Rraklli V, Maxymovitz E, Cipullo M, Liu M, Li S, Westerlund I, Bedoya-Reina OC, Bullova P, Rorbach J, Juhlin CC, Stenman A, Larsson C, Kogner P, O'Sullivan MJ, Schlisio S, Holmberg J.
Nucleic Acids Res. 2021 Mar 18;49(5):2509-2521. doi: 10.1093/nar/gkab054.

Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?
Bedoya-Reina OC, Schlisio S.
Cancer Cell. 2021 Feb 8;39(2):134-135. doi: 10.1016/j.ccell.2020.12.009. Epub 2020 Dec 31.

EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance.
Li S, Rodriguez J, Li W, Bullova P, Fell SM, Surova O, et al
Proc. Natl. Acad. Sci. U.S.A. 2019 Aug;116(34):16997-17006

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.
Rodriguez J, Herrero A, Li S, Rauch N, Quintanilla A, Wynne K, et al
Cell Rep 2018 07;24(5):1316-1329

Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression.
Westerlund I, Shi Y, Toskas K, Fell SM, Li S, Surova O, et al
Proc. Natl. Acad. Sci. U.S.A. 2017 07;114(30):E6137-E6146

Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA.
Fell SM, Li S, Wallis K, Kock A, Surova O, Rraklli V, et al
Genes Dev. 2017 05;31(10):1036-1053

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.
Li S, Fell SM, Surova O, Smedler E, Wallis K, Chen ZX, et al
Dev. Cell 2016 Jan;36(2):164-78

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.
Koivunen P, Fell SM, Lu W, Rabinowitz JD, Kung AL, Schlisio S
Hypoxia (Auckl) ;4():15-27

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis.
Choo Z, Koh RY, Wallis K, Koh TJ, Kuick CH, Sobrado V, et al
Oncotarget 2016 Jun;7(23):34229-39

RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma.
Chen ZX, Wallis K, Fell SM, Sobrado VR, Hemmer MC, Ramsköld D, et al
Cancer Discov 2014 Apr;4(4):434-51

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, et al
Endocr. Relat. Cancer 2011 Feb;18(1):73-83

Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum.
Schlisio S
J. Cell. Mol. Med. 2009 Oct;13(10):4104-12

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, et al
Genes Dev. 2008 Apr;22(7):884-93

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, et al
Nat. Cell Biol. 2008 Mar;10(3):361-9

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.
Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, et al
Mol. Cell 2007 Oct;28(1):15-27

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, et al
Cancer Cell 2005 Aug;8(2):155-67