Diabetes is a common disease which, primarily by the complications it entails, leads to great personal suffering and high costs for society in terms of sick leave, health care and premature death. It has been estimated that diabetes is the fifth leading cause of death worldwide (Roglic 2005). LADA (latent autoimmune diabetes in adults) is believed to be the second most common form of diabetes after type 2 diabetes and thus encompasses a significant proportion of the diabetic population. Despite this, the aetiology of LADA is largely unknown. The aim of ESTRID (epidemiological study of risk factors for LADA and type 2 diabetes) is to study the influence of environmental and genetic factors on the risk of LADA and type 2 diabetes.
ESTRID is a case-control study based on incident cases of diabetes identified through two new diabetes registries in Skåne (ANDIS – all new diabetes cases in Skåne) and Uppsala (ANDiU – all new diabetes cases in Uppsala), together with and a random sample of the general population of Skåne and Uppsala. Information on lifestyle and environmental factors such as socio-demographics, smoking, snuff use, alcohol consumption, diet, stress, sleep, infections, vaccinations, and allergies is collected by questionnaire. Genetic information is also available through blood samples collected in ANDIS and ANDiU. This will allow us to investigate a large number of hypotheses regarding the etiology of LADA, including gene-environment interactions. Data collection was started in 2010 (2012 in Uppsala) and will continue through 2016. ESTRID is a collaboration between IMM, Lund University, and Uppsala University.
The study is funded by the Swedish Research Council, Forte (Swedish Research Council for Health, Working Life and Welfare), Swedish Diabetes Association, and AFA Insurance AB.