Susanne Schlisios forskargrupp

Article: NATURE METABOLISM. 2022;4(6):739-758

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.

Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sörensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S

Article: NATURE COMMUNICATIONS. 2021;12(1):5309

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.

Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S

Article: NUCLEIC ACIDS RESEARCH. 2021;49(5):2509-2521

Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.

Shi Y; Yuan J; Rraklli V; Maxymovitz E; Cipullo M; Liu M; Li S; Westerlund I; Bedoya-Reina OC; Bullova P; Rorbach J; Juhlin CC; Stenman A; Larsson C; Kogner P; O'Sullivan MJ; Schlisio S; Holmberg J

Letter: CANCER CELL. 2021;39(2):134-135

Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

Bedoya-Reina OC; Schlisio S

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006

EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance.

Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nistér M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WG; Schlisio S

Article: CELL REPORTS. 2018;24(5):1316-1329

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.

Rodriguez J; Herrero A; Li S; Rauch N; Quintanilla A; Wynne K; Krstic A; Acosta JC; Taylor C; Schlisio S; von Kriegsheim A

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6137-E6146

Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression.

Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Surova O; Södersten E; Kogner P; Nyman U; Schlisio S; Holmberg J

Article: GENES & DEVELOPMENT. 2017;31(10):1036-1053

Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA.

Fell SM; Li S; Wallis K; Kock A; Surova O; Rraklli V; Höfig CS; Li W; Mittag J; Henriksson MA; Kenchappa RS; Holmberg J; Kogner P; Schlisio S

Article: ONCOTARGET. 2016;7(23):34229-34239

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis.

Choo Z; Koh RYL; Wallis K; Koh TJW; Kuick CH; Sobrado V; Kenchappa RS; Loh AHP; Soh SY; Schlisio S; Chang KTE; Chen ZX

Article: DEVELOPMENTAL CELL. 2016;36(2):164-178

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.

Li S; Fell SM; Surova O; Smedler E; Wallis K; Chen ZX; Hellman U; Johnsen JI; Martinsson T; Kenchappa RS; Uhlén P; Kogner P; Schlisio S

Article: HYPOXIA (AUCKL). 2016;4:15-27

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.

Koivunen P; Fell SM; Lu W; Rabinowitz JD; Kung AL; Schlisio S

Article: CANCER DISCOVERY. 2014;4(4):434-451

RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma.

Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramsköld D; Hellman U; Sandberg R; Kenchappa RS; Martinson T; Johnsen JI; Kogner P; Schlisio S

Article: ENDOCRINE-RELATED CANCER. 2010;18(1):73-83

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.

Astuti D; Ricketts CJ; Chowdhury R; McDonough MA; Gentle D; Kirby G; Schlisio S; Kenchappa RS; Carter BD; Kaelin WG; Ratcliffe PJ; Schofield CJ; Latif F; Maher ER

Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(10):4104-4112

Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum.

Schlisio S

Article: GENES & DEVELOPMENT. 2008;22(7):884-893

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.

Schlisio S; Kenchappa RS; Vredeveld LCW; George RE; Stewart R; Greulich H; Shahriari K; Nguyen NV; Pigny P; Dahia PL; Pomeroy SL; Maris JM; Look AT; Meyerson M; Peeper DS; Carter BD; Kaelin WG

Article: NATURE CELL BIOLOGY. 2008;10(3):361-369

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

Young AP; Schlisio S; Minamishima YA; Zhang Q; Li L; Grisanzio C; Signoretti S; Kaelin WG

Article: MOLECULAR CELL. 2007;28(1):15-27

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.

Yang H; Minamishima YA; Yan Q; Schlisio S; Ebert BL; Zhang X; Zhang L; Kim WY; Olumi AF; Kaelin WG

Article: CANCER CELL. 2005;8(2):155-167

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

Lee S; Nakamura E; Yang H; Wei W; Linggi MS; Sajan MP; Farese RV; Freeman RS; Carter BD; Kaelin WG; Schlisio S

Susanne Schlisios forskargrupp

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