Hans-Gustaf Ljunggren

About me
Publications
Grants
CV
Public outreach and news

About me

MD and PhD Karolinska Institutet (KI), 1982-1992. Post doc M.I.T., Boston, USA, 1992-1994. Group leader, Dept of Microbiology Tumor and Cell Biology (MTC), KI, 1994-2000. Professor at the Department of Medicine (H7), KI, 2001-.

Commission of trust

Chairman Medical Student Association, KI, 1985. Scientific Secretary, Swedish Cancer Society, 1998-2002. Member Board of Research, KI, 2005-2011, and KI University Board, KI, 2011-2013. Vice department head, Department of Medicine (H7), 2008-2013. Member of the Nobel Assembly at KI, 2008-. Dean of Research, KI, 2013-2016. 2020- Director NextGenNK Competence Center founded by Sweden's Innovation Agency.

Research

Our group has a long-term interest in exploring the function of human immune reaction in cancer and infectious diseases.

Within the field of cancer, we study NK cell reactivates towards tumor cells and explore the potential of using NK cells in therapeutic settings. Within the field of infectious diseases, we explore immune reactions towards flavivirus infections (in particular TBEV, JFV, and JEV), hantavirus infections, and SARS-CoV-2 infections. With respect to flavivirus infections and SARS-CoV-2 infections we also explore vaccine responses in humans vaccinated with existing vaccines.

Articles

Journal article: JOURNAL OF HUMAN IMMUNITY. 2025;1(2):e20250029
Inborn errors of immunity affecting the MHC class I pathway for antigen presentation
Gadola SD; Ardeniz Ö; Cuapio A; Zimmer J; Ljunggren H-G
Article: GENES AND IMMUNITY. 2025;26(1):70-74
The HLA-B-21 M/T dimorphism associates with disease severity in COVID-19
Strunz B; Momayyezi P; Bilev E; Muvva JR; Chen P; Bister J; Schaffer M; Akber M; Cornillet M; Horowitz A; Malmberg K-J; Rooyackers O; Aleman S; Ljunggren H-G; Bjorkstrom NK; Stralin K; Hammer Q
Article: PLOS NEGLECTED TROPICAL DISEASES. 2025;19(2):e0012693
Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort
Wullimann D; Sandberg JT; Akber M; Lofling M; Gredmark-Russ S; Michaelsson J; Buggert M; Blom K; Ljunggren H-G
Article: PLOS PATHOGENS. 2024;20(12):e1012755
Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness
Bilev E; Wild N; Momayyezi P; Sala BM; Sun R; Sandalova T; Marquardt N; Ljunggren H-G; Achour A; Hammer Q
Journal article: BLOOD. 2024;144:7234
Feasibility of Co-Administration of Autologous NK Cells and Anti-CD38 Monoclonal Antibody Isatuximab, in Multiple Myeloma Post-Autologous HSCT in a Randomized Phase 2 Clinical Trial
Lund J; Meinke S; Kashif M; Bohlin A; Lindberg EH; Ljunggren H-G; Alici E
Article: EBIOMEDICINE. 2024;109:105385
Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a two-year follow-up of the prospective clinical trial COVAXID
Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Gao Y; Soderdahl G; Osterborg A; Smith CIE; Vesterbacka J; Wullimann D; Cuapio A; Akber M; Bogdanovic G; Muschiol S; Aberg M; Lore K; Chen MS; Ljungman P; Buggert M; Aleman S; Ljunggren H-G
Article: BLOOD. 2024;144(8):873-887
Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis
Chiang SCC; Covill LE; Tesi B; Campbell TM; Schlums H; Nejati-Zendegani J; Mordrup K; Wood S; Theorell J; Sekine T; Al-Herz W; Akar HH; Belen FB; Chan MY; Devecioglu O; Aksu T; Ifversen M; Malinowska I; Sabel M; Unal E; Unal S; Introne WJ; Krzewski K; Gilmour KC; Ehl S; Ljunggren H-G; Nordenskjold M; Horne A; Henter J-I; Meeths M; Bryceson YT
Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326
Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingstrom J; Geanon D; Parke A; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarstrom Q; Lund-Johansen F; Stralin K; Bjorkstrom NK
Article: SCIENTIFIC REPORTS. 2024;14(1):17820
Exploring the interplay between antiretroviral therapy and the gut-oral microbiome axis in people living with HIV
Narayanan A; Kieri O; Vesterbacka J; Manoharan L; Chen P; Ghorbani M; Ljunggren H-G; Chen MS; Aleman S; Soennerborg A; Ray S; Nowak P
Article: CELL HOST & MICROBE. 2024;32(2):156-161.e3
Memory T cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant
Muller TR; Gao Y; Wu J; Ribeiro O; Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Soderdahl G; Smith CIE; Lore K; Chen MS; Ljungman P; Ingelman-Sundberg HM; Ljunggren H-G; Osterborg A; Sette A; Grifoni A; Aleman S; Buggert M
Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
Dynamic MAIT Cell Recovery after Severe COVID-19 Is Transient with Signs of Heterogeneous Functional Anomalies
Kammann T; Gorin J-B; Parrot T; Gao Y; Ponzetta A; Emgard J; Maleki KT; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Skagerberg M; Eriksson LI; Norrby-Teglund A; Mak JYW; Fairlie DP; Bjorkstrom NK; Klingstrom J; Ljunggren H-G; Aleman S; Buggert M; Stralin K; Sandberg JK
Article: CRYSTALS. 2024;14(12):1094
Crystallographic and NMR Study of Streptococcus pneumonia LCP Protein Psr_Sp Indicate the Importance of Dynamics in Four Long Loops for Ligand Specificity
Sandalova T; Sala BM; Moche M; Ljunggren H-G; Alici E; Henriques-Normark B; Agback T; Lesovoy D; Agback P; Achour A
Article: ONCOIMMUNOLOGY. 2023;12(1):2233402
Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8⁺ T cells towards the center of human lung tumors
Brownlie D; von Kries A; Valenzano G; Wild N; Yilmaz E; Safholm J; Al-Ameri M; Alici E; Ljunggren H-G; Schliemann I; Aricak O; de Flon FH; Michaelsson J; Marquardt N
Article: NPJ BIOFILMS AND MICROBIOMES. 2023;9(1):104
Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV
Ray S; Narayanan A; Vesterbacka J; Blennow O; Chen P; Gao Y; Gabarrini G; Ljunggren H-G; Buggert M; Manoharan L; Chen MS; Aleman S; Sonnerborg A; Nowak P
Article: SCIENCE IMMUNOLOGY. 2023;8(90):eadh0687
SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19
Cai C; Gao Y; Adamo S; Rivera-Ballesteros O; Hansson L; Osterborg A; Bergman P; Sandberg JK; Ljunggren H-G; Bjorkstrom NK; Stralin K; Llewellyn-Lacey S; Price DA; Qin C; Grifoni A; Weiskopf D; Wherry EJ; Sette A; Aleman S; Buggert M
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2023;114(5):507-512
NK cells in COVID-19-from disease to vaccination
Hammer Q; Cuapio A; Bister J; Bjoerkstroem NK; Ljunggren H-G
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2023;43(6):1075-1082
SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Show Markedly Reduced Cross-reactivities Against Omicron Variants
Lindahl H; Chen P; Aberg M; Ljunggren H-G; Buggert M; Aleman S; Smith CIE; Bergman P
Article: EBIOMEDICINE. 2023;94:104700
Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXID
Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Soderdahl G; oesterborg A; Smith CIE; Vesterbacka J; Wullimann D; Cuapio A; Akber M; Bogdanovic G; Muschiol S; aberg M; Lore K; Chen MS; Buggert M; Ljungman P; Aleman S; Ljunggren H-G
Article: JOURNAL OF HEMATOLOGY. 2023;12(4):170-175
Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia
Andersson M; Wu J; Wullimann D; Gao Y; Aberg M; Muschiol S; Healy K; Naud S; Bogdanovic G; Palma M; Mellstedt H; Chen P; Ljunggren H-G; Hansson L; Chen MS; Buggert M; Ingelman-Sundberg HM; Osterborg A
Article: SCIENCE TRANSLATIONAL MEDICINE. 2023;15(704):eadg9452
Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states
Muller TRR; Sekine T; Trubach D; Niessl J; Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Olofsson A; Hernandez SPA; Gao Y; Cai C; Soderdahl G; Smith CIE; Osterborg A; Lore K; Sallberg Chen M; Ljungman P; Ljunggren H-G; Karlsson ACC; Saini SK; Aleman S; Buggert M
Article: CYTOTHERAPY. 2023;25(7):763-772
Challenges in αCD38-chimeric antigen receptor (CAR)-expressing natural killer (NK) cell-based immunotherapy in multiple myeloma: Harnessing the CD38dim phenotype of cytokine-stimulated NK cells as a strategy to prevent fratricide
Karvouni M; Vidal-Manrique M; Susek KH; Hussain A; Gilljam M; Zhang Y; Gray JD; Lund J; Kaufmann G; Ljunggren H-G; Ji H; Lundqvist A; Wagner AK; Guo W; Alici E
Article: CELL HOST & MICROBE. 2023;31(6):928-936.e4
Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox
Adamo S; Gao Y; Sekine T; Mily A; Wu J; Storgard E; Westergren V; Filen F; Sandberg JK; Sallberg M; Bergman P; Llewellyn-Lacey S; Ljunggren H-G; Price DA; Ekstrom A-M; Sette A; Grifoni A; Buggert M
Journal article: CYTOTHERAPY. 2023;25(6):s13-s14
13 Tissue Engineering: GENERATION OF UNIVERSAL CELLULAR GRAFTS UTILIZING SIGNALING-DEFICIENT MEMBRANE-BOUND CD45 ENGAGERS
Hussain A; Mohammad DK; Karvouni M; Hållstrand C; Gilljam M; Wagner AK; Ljunggren H; Alici E
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(Supplement_1):75.16
Anamnestic expansion of Omicron-reactive CD8+ T cells after booster SARS-CoV-2 mRNA vaccination across different immunocompromised states
Müller TR; Sekine T; Trubach D; Niessl J; Olofsson A; Gao Y; Cai C; Nowak P; Blennow O; Hansson L; Mielke S; Bergman P; Ljunggren H-G; Karlsson AC; Saini SK; Aleman S; Buggert M
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(Supplement_1):75.20
Pre-existing SARS-CoV-2-reactive CD4+ T cells are established and highly functional in early childhood
Olofsson A; Humbert M; Niessl J; Hodcroft E; Gao Y; Sohlberg E; Malmberg K-J; Lund-Johansen F; Björkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2023;72(5):1153-1167
Generation of NK cells with chimeric-switch receptors to overcome PD1-mediated inhibition in cancer immunotherapy
Susek KH; Schwietzer YA; Karvouni M; Gilljam M; Keszei M; Hussain A; Lund J; Kashif M; Lundqvist A; Ljunggren H-G; Nahi H; Wagner AK; Alici E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(12):e2220320120
Functional SARS-CoV-2 cross-reactive CD4⁺ T cells established in early childhood decline with age
Humbert M; Olofsson A; Wullimann D; Niessl J; Hodcroft EB; Cai C; Gao Y; Sohlberg E; Dyrdak R; Mikaeloff F; Neogi U; Albert J; Malmberg K-J; Lund-Johansen F; Aleman S; Bjorkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Article: RESPIRATORY RESEARCH. 2023;24(1):62
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
Article: PLOS NEGLECTED TROPICAL DISEASES. 2023;17(2):e0010616
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial.
Sandberg JT; Löfling M; Varnaitė R; Emgård J; Al-Tawil N; Lindquist L; Gredmark-Russ S; Klingström J; Loré K; Blom K; Ljunggren H-G
Article: PLOS ONE. 2023;18(12):e0295838
Anakinra or tocilizumab in patients admitted to hospital with severe covid-19 at high risk of deterioration (IMMCoVA): A randomized, controlled, open-label trial
Sunden-Cullberg J; Chen P; Habel H; Skorup P; Janols H; Rasmuson J; Niward K; Balkhed AO; Chatzidionysiou K; Asgeirsson H; Blennow O; Parke A; Svensson A-K; Muvva JR; Ljunggren H-G; Horne A-C; Aden U; Henter J-I; Sonnerborg A; Vesterbacka J; Nowak P; Lampa J
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(11):e005577
Adaptive single-KIR⁺NKG2C⁺ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia
Haroun-Izquierdo A; Vincenti M; Netskar H; van Ooijen H; Zhang B; Bendzick L; Kanaya M; Momayyezi P; Li S; Wiiger MT; Hoel HJ; Krokeide SZ; Kremer V; Tjonnfjord G; Berggren S; Wikstroem K; Blomberg P; Alici E; Felices M; oenfelt B; Hoeglund P; Valamehr B; Ljunggren H-G; Bjoerklund A; Hammer Q; Kveberg L; Cichocki F; Miller JS; Malmberg K-J; Sohlberg E
Article: IMMUNITY. 2022;55(9):1732-1746.e5
Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
Gao Y; Cai C; Wullimann D; Niessl J; Rivera-Ballesteros O; Chen P; Lange J; Cuapio A; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Perez-Potti A; Sekine T; Muller TR; Boulouis C; Kammann T; Parrot T; Muvva JR; Sobkowiak M; Healy K; Bogdanovic G; Muschiol S; Soderdahl G; Osterborg A; Hellgren F; Grifoni A; Weiskopf D; Sette A; Lore K; Chen MS; Ljungman P; Sandberg JK; Smith CIE; Bergman P; Ljunggren H-G; Aleman S; Buggert M
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(6):1130-1136
Neutralizing SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Give Patients with X-Linked Agammaglobulinemia Limited Passive Immunity to the Omicron Variant
Lindahl H; Klingstrom J; Da Silva Rodrigues R; Christ W; Chen P; Ljunggren H-G; Buggert M; Aleman S; Smith CIE; Bergman P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
The Karolinska KI/K COVID-19 immune atlas: An open resource for immunological research and educational purposes
Ljunggren H-G; Heggernes Ask E; Cornillet Jeannin M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio Gomez A; Dzidic M; Filipovic I; Flodstrom-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Eriksson LI; Aleman S; Malmberg K-J; Stralin K; Bjorkstrom NK
Journal article: HEMASPHERE. 2022;6(Suppl ):1326-1327
P1443: AUTOLOGOUS NK CELLS AS CONSOLIDATION AFTER FRONT-LINE STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA: A LONG-TERM FOLLOW-UP
Lund J; Nahi H; Meinke S; Holmqvist P-H; Ljunggren H-G; Aschan J; Alici E
Article: MOLECULAR MEDICINE. 2022;28(1):54
MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine
Boulouis C; Kammann T; Cuapio A; Parrot T; Gao Y; Mouchtaridi E; Wullimann D; Lange J; Chen P; Akber M; Ballesteros OR; Muvva JR; Smith CIE; Vesterbacka J; Kieri O; Nowak P; Bergman P; Buggert M; Ljunggren H-G; Aleman S; Sandberg JK
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(4):716-727
Elevated CD21^low B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency
Bergman P; Wullimann D; Gao Y; Borgstrom EW; Norlin A-C; Enoksson SL; Aleman S; Ljunggren H-G; Buggert M; Smith CIE
Article: CELL REPORTS. 2022;38(10):110503
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Hammer Q; Dunst J; Christ W; Picarazzi F; Wendorff M; Momayyezi P; Huhn O; Netskar HK; Maleki KT; Garcia M; Sekine T; Sohlberg E; Azzimato V; Aouadi M; Degenhardt F; Franke A; Spallotta F; Mori M; Michaelsson J; Bjorkstrom NK; Rueckert T; Romagnani C; Horowitz A; Klingstrom J; Ljunggren H-G; Malmberg K-J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations
Cornillet M; Strunz B; Rooyackers O; Ponzetta A; Chen P; Muvva JR; Akber M; Buggert M; Chambers BJ; Dzidic M; Filipovic I; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Parrot T; Perez-Potti A; Rivera-Ballesteros O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Eriksson LI; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK
Article: NATURE MEDICINE. 2022;28(3):472-476
Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant
Gao Y; Cai C; Grifoni A; Muller TR; Niessl J; Olofsson A; Humbert M; Hansson L; Osterborg A; Bergman P; Chen P; Olsson A; Sandberg JK; Weiskopf D; Price DA; Ljunggren H-G; Karlsson AC; Sette A; Aleman S; Buggert M
Article: CELL REPORTS MEDICINE. 2022;3(2):100508
Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma
Nahi H; Chrobok M; Meinke S; Gran C; Marquardt N; Afram G; Sutlu T; Gilljam M; Stellan B; Wagner AK; Blomberg P; Holmqvist P-H; Walther-Jallow L; Mellstrom K; Liwing J; Gustafsson C; Mansson R; Klimkowska M; Gahrton G; Lund J; Ljungman P; Ljunggren H-G; Alici E
Article: MED. 2022;3(2):137-153.e3
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals
Healy K; Pin E; Chen P; Soderdahl G; Nowak P; Mielke S; Hansson L; Bergman P; Smith CIE; Ljungman P; Valentini D; Blennow O; Osterborg A; Gabarrini G; Al-Manei K; Alkharaan H; Sobkowiak MJ; Yousef J; Mravinacova S; Cuapio A; Xu X; Akber M; Lore K; Hellstrom C; Muschiol S; Bogdanovic G; Buggert M; Ljunggren H-G; Hober S; Nilsson P; Aleman S; Chen MS
Article: MOLECULAR MEDICINE. 2022;28(1):20
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals
Cuapio A; Boulouis C; Filipovic I; Wullimann D; Kammann T; Parrot T; Chen P; Akber M; Gao Y; Hammer Q; Strunz B; Potti AP; Ballesteros OR; Lange J; Muvva JR; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Soderdahl G; Osterborg A; Smith CIE; Bogdanovic G; Muschiol S; Hellgren F; Lore K; Sobkowiak MJ; Gabarrini G; Healy K; Chen MS; Alici E; Bjorkstrom NK; Buggert M; Ljungman P; Sandberg JK; Aleman S; Ljunggren H-G
Journal article: NATURE MEDICINE. 2022
Ancestral SARS-CoV-2-specific T cells cross-recognize Omicron
Gao Y; Cai C; Grifoni A; Müller TR; Niessl J; Olofsson A; Humbert M; Hansson L; Österborg A; Bergman P; Chen P; Olsson A; Sandberg JK; Weiskopf D; Price DA; Ljunggren H-G; Karlsson AC; Sette A; Aleman S; Buggert M
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862
Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza
Brownlie D; Rodahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaelsson J; Gredmark-Russ S; Smed-Sorensen A; Marquardt N
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1079995
Persistence of salivary antibody responses after COVID-19 vaccination is associated with oral microbiome variation in both healthy and people living with HIV
Ghorbani M; Al-Manei K; Naud S; Healy K; Gabarrini G; Sobkowiak MJ; Chen P; Ray S; Akber M; Muschiol S; Bogdanovic G; Bergman P; Ljungman P; Buggert M; Ljunggren H-G; Pin E; Nowak P; Aleman S; Saellberg Chen M
Article: LAKARTIDNINGEN. 2021;118:21163
[Insights from creating a covid-19 biobank in Sweden].
Ljunggren H-G; Strålin K; Chen P; Cornillet M; Rooijackers O; I Eriksson L; Aleman S; Björkström N
Article: EBIOMEDICINE. 2021;74:103705
Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial
Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Chen P; Soderdahl G; Osterborg A; Smith CIE; Wullimann D; Vesterbacka J; Lindgren G; Blixt L; Friman G; Wahren-Borgstrom E; Nordlander A; Gomez AC; Akber M; Valentini D; Norlin A-C; Thalme A; Bogdanovic G; Muschiol S; Nilsson P; Hober S; Lore K; Chen MS; Buggert M; Ljunggren H-G; Ljungman P; Aleman S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2021;207(4):1033-1043
Activation and Kinetics of Circulating T Follicular Helper Cells, Specific Plasmablast Response, and Development of Neutralizing Antibodies following Yellow Fever Virus Vaccination
Sandberg JT; Ols S; Lofling M; Varnait R; Lindgren G; Nilsson O; Rombo L; Kale M; Lore K; Blom K; Ljunggren H-G; Lindgren G; Nilsson O; Rombo L; Kale M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118
Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood
Brownlie D; Scharenberg M; Mold JE; Hard J; Kekalainen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Marquardt N; Michaelsson J
Article: CELL REPORTS MEDICINE. 2021;2(3):100220
MAIT cell activation is associated with disease severity markers in acute hantavirus infection
Maleki KT; Tauriainen J; Garcia M; Kerkman PF; Christ W; Dias J; Bystrom JW; Leeansyah E; Forsell MN; Ljunggren H-G; Ahlm C; Bjorkstrom NK; Sandberg JK; Klingstrom J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation
Sandberg JT; Varnaite R; Christ W; Chen P; Muvva JR; Maleki KT; Garcia M; Dzidic M; Folkesson E; Skagerberg M; Ahlen G; Frelin L; Sallberg M; Eriksson LI; Rooyackers O; Sonnerborg A; Buggert M; Bjorkstrom NK; Aleman S; Stralin K; Klingstrom J; Ljunggren H-G; Blom K; Gredmark-Russ S
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2020;105(6):751-754
Outcome of COVID-19 in multiple myeloma patients in relation to treatment
Susek KH; Gran C; Ljunggren H-G; Alici E; Nahi H
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(6):e12997
Covid-19, SSI 50 years and Nobel: Three immunological reasons to remember 2020.
Höglund P; Ljunggren H-G; Jonsson R
Article: JOURNAL OF IMMUNOLOGY. 2020;205(9):2437-2446
Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients
Varnaite R; Garcia M; Glans H; Maleki KT; Sandberg JT; Tynell J; Christ W; Lagerqvist N; Asgeirsson H; Ljunggren H-G; Ahlen G; Frelin L; Sallberg M; Blom K; Klingstrom J; Gredmark-Russ S
Article: CELL. 2020;183(1):158-168.e14
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
MAIT cell activation and dynamics associated with COVID-19 disease severity
Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
Natural killer cell immunotypes related to COVID-19 disease severity
Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
Article: JOURNAL OF IMMUNOLOGY. 2020;204(4):914-922
Magnitude and Functional Profile of the Human CD4⁺ T Cell Response throughout Primary Immunization with Tick-Borne Encephalitis Virus Vaccine
Varnaite R; Blom K; Lampen MH; Vene S; Thunberg S; Lindquist L; Ljunggren H-G; Rombo L; Askling HH; Gredmark-Russ S
Article: PLOS PATHOGENS. 2020;16(2):e1008297
Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2
Sola-Riera C; Garcia M; Ljunggren H-G; Klingstrom J
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(12):e1224
Innate lymphoid cell composition associates with COVID-19 disease severity
Garcia M; Kokkinou E; Carrasco Garcia A; Parrot T; Palma Medina LM; Maleki KT; Christ W; Varnaite R; Filipovic I; Ljunggren H-G; Bjorkstrom NK; Folkesson E; Rooyackers O; Eriksson LI; Sonnerborg A; Aleman S; Stralin K; Gredmark-Russ S; Klingstrom J; Mjosberg J
Article: JOURNAL OF IMMUNOLOGY. 2019;203(8):2210-2221
Terminal Effector CD8 T Cells Defined by an IKZF2⁺IL-7R^- Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity
Naluyima P; Lal KG; Costanzo MC; Kijak GH; Gonzalez VD; Blom K; Eller LA; Creegan M; Hong T; Kim D; Quinn TC; Bjorkstrom NK; Ljunggren H-G; Serwadda D; Katabira ET; Sewankambo NK; Gray RH; Baeten JM; Michael NL; Wabwire-Mangen F; Robb ML; Bolton DL; Sandberg JK; Eller MA
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(10):1457-1973
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
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Article: NATURE COMMUNICATIONS. 2019;10(1):3897
NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
Zimmer CL; Cornillet M; Sola-Riera C; Cheung K-W; Ivarsson MA; Lim MQ; Marquardt N; Leo Y-S; Lye DC; Klingstrom J; MacAry PA; Ljunggren H-G; Rivino L; Bjorkstrom NK
Article: NATURE COMMUNICATIONS. 2019;10(1):3841
Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
Marquardt N; Kekalainen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hard J; Mold JE; Ljunggren H-G; Michaelsson J
Article: CELL REPORTS. 2019;28(8):2124-2139.e6
Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5
Sola-Riera C; Gupta S; Maleki KT; Gonzalez-Rodriguez P; Saidi D; Zimmer CL; Vangeti S; Rivino L; Leo Y-S; Lye DC; MacAry PA; Ahlm C; Smed-Sorensen A; Joseph B; Bjorkstrom NK; Ljunggren H-G; Klingstrom J
Article: JOURNAL OF HEPATOLOGY. 2019;71(2):301-312
Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells
Dias J; Hengst J; Parrot T; Leeansyah E; Lunemann S; Malone DFG; Hardtke S; Strauss O; Zimmer CL; Berglin L; Schirdewahn T; Ciesek S; Marquardt N; von Hahn T; Manns MP; Cornberg M; Ljunggren H-G; Wedemeyer H; Sandberg JK; Bjorkstrom NK
Article: JOURNAL OF INFECTIOUS DISEASES. 2019;219(11):1832-1840
Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome
Maleki KT; Garcia M; Iglesias A; Alonso D; Ciancaglini M; Hammar U; Ljunggren H-G; Schierloh P; Martinez VP; Klingstrom J
Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(5):510-523
Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes
Klingstrom J; Smed-Sorensen A; Maleki KT; Sola-Riera C; Ahlm C; Bjorkstrom NK; Ljunggren HG
Article: SCIENTIFIC REPORTS. 2019;9(1):834
Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells
Sola-Riera C; Gupta S; Ljunggren H-G; Klingstrom J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1116
Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells
Scharenberg M; Vangeti S; Kekalainen E; Bergman P; Al-Ameri M; Johansson N; Sonden K; Falck-Jones S; Farnert A; Ljunggren H-G; Michaelsson J; Smed-Sorensen A; Marquardt N
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2018;88(6):e12731
Seminal immunologic discoveries with direct clinical implications: The 2018 Nobel Prize in Physiology or Medicine honours discoveries in cancer immunotherapy.
Ljunggren H-G; Jonsson R; Höglund P
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(9):1456-1469
Proteome analysis of human CD56^neg NK cells reveals a homogeneous phenotype surprisingly similar to CD56^dim NK cells
Voigt J; Malone DFG; Dias J; Leeansyah E; Bjorkstrom NK; Ljunggren H-G; Groebe L; Klawonn F; Heyner M; Sandberg JK; Jaensch L
Article: IMMUNOHORIZONS. 2018;2(6):172-184
Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.
Lampen MH; Uchtenhagen H; Blom K; Varnaitė R; Pakalniene J; Dailidyte L; Wälchli S; Lindquist L; Mickiene A; Michaëlsson J; Schumacher TN; Ljunggren H-G; Sandberg JK; Achour A; Gredmark-Russ S
Article: NATURE COMMUNICATIONS. 2018;9(1):2275
Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
Strunz B; Hengst J; Deterding K; Manns MP; Cornberg M; Ljunggren H-G; Wedemeyer H; Bjorkstrom NK
Article: CLINICAL CANCER RESEARCH. 2018;24(8):1834-1844
Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
Bjorklund AT; Carlsten M; Sohlberg E; Liu LL; Clancy T; Karimi M; Cooley S; Miller JS; Klimkowska M; Schaffer M; Watz E; Wikstrom K; Blomberg P; Wahlin BE; Palma M; Hansson L; Ljungman P; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294
Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M; Berglin L; Kekalainen E; Carlsson A; Svedin E; Michaelsson J; Nagasawa M; Erjefalt JS; Mori M; Flodstrom-Tullberg M; Bergquist A; Ljunggren H-G; Westgren M; Lindforss U; Friberg D; Jorns C; Ellis E; Bjorkstrom NK; Mjosberg J
Article: JOURNAL OF AUTOIMMUNITY. 2017;81:1-12
Contribution of inhibitory receptor TIGIT to NK cell education
He Y; Peng H; Sun R; Wei H; Ljunggren H-G; Yokoyama WM; Tian Z
Article: PLOS PATHOGENS. 2017;13(6):e1006462
Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways
Scholz S; Baharom F; Rankin G; Maleki KT; Gupta S; Vangeti S; Pourazar J; Discacciati A; Hoijer J; Bottai M; Bjorkstrom NK; Rasmuson J; Evander M; Blomberg A; Ljunggren H-G; Klingstrom J; Ahlm C; Smed-Sorensen A
Journal article: JOURNAL OF IMMUNOLOGY. 2017;198(Supplement_1):78.25
HIV-induced modifications of TIGIT expression impair CD8 T cell polyfunctionality
Scharf L; Tauriainen J; Frederiksen J; Naji A; Ljunggren H-G; Sönnerborg A; Lund O; Reyes-Terán G; Hecht FM; Deeks SG; Betts MR; Buggert M; Karlsson AC
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4
Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69^-CD56^dim cells
Marquardt N; Kekalainen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjosberg J; Berglin L; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
Article: SCIENTIFIC REPORTS. 2017;7:40354
Perturbed CD8⁺ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals
Tauriainen J; Scharf L; Frederiksen J; Naji A; Ljunggren H-G; Sonnerborg A; Lund O; Reyes-Teran G; Hecht FM; Deeks SG; Betts MR; Buggert M; Karlsson AC
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:525
Cytomegalovirus-Driven Adaptive-Like Natural Killer Cell Expansions Are Unaffected by Concurrent Chronic Hepatitis Virus Infections
Malone DFG; Lunemann S; Hengst J; Ljunggren H-G; Manns MP; Sandberg JK; Cornberg M; Wedemeyer H; Bjorkstrom NK
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:426
Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients
Chiang SCC; Wood SM; Tesi B; Akar HH; Al-Herz W; Ammann S; Belen FB; Caliskan U; Kaya Z; Lehmberg K; Patiroglu T; Tokgoz H; Unuvar A; Introne WJ; Henter J-I; Nordenskjold M; Ljunggren H-G; Meeths M; Ehl S; Krzewski K; Bryceson YT
Journal article: ZEITSCHRIFT FUR GASTROENTEROLOGIE. 2016;54(12):1343-1404
NK cell responses during direct-acting antiviral treatment of chronic hepatitis C virus infection
Hengst J; Strunz B; Deterding K; Schlaphoff V; Manns M; Ljunggren H; Björkström N; Wedemeyer H
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2762-2771
NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection
Blom K; Braun M; Pakalniene J; Lunemann S; Enqvist M; Dailidyte L; Schaffer M; Lindquist L; Mickiene A; Michaelsson J; Ljunggren H-G; Gredmark-Russ S
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(9):2204-2210
Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy
Hengst J; Strunz B; Deterding K; Ljunggren H-G; Leeansyah E; Manns MP; Cornberg M; Sandberg JK; Wedemeyer H; Bjorkstrom NK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(7):1758-1769
In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation
Lakshmikanth T; Heuts F; Muvva SSVJR; Wallin RPA; Persson A-K; Fauriat C; Applequist SE; Ljunggren H-G; Hoglund P; Karre K; Svensson M; Juarez JG
Article: CELL REPORTS. 2016;15(5):1088-1099
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Liu LL; Landskron J; Ask EH; Enqvist M; Sohlberg E; Traherne JA; Hammer Q; Goodridge JP; Larsson S; Jayaraman J; Oei VYS; Schaffer M; Tasken K; Ljunggren H-G; Romagnani C; Trowsdale J; Malmberg K-J; Beziat V
Article: JOURNAL OF IMMUNOLOGY. 2016;196(3):1400-1411
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
Bjorklund AT; Clancy T; Goodridge JP; Beziat V; Schaffer M; Hovig E; Ljunggren H-G; Ljungman PT; Malmberg K-J
Article: IMMUNITY. 2015;42(3):443-456
Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function
Schlums H; Cichocki F; Tesi B; Theorell J; Beziat V; Holmes TD; Han H; Chiang SCC; Foley B; Mattsson K; Larsson S; Schaffer M; Malmberg K-J; Ljunggren H-G; Miller JS; Bryceson YT
Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471
Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a⁺ NK Cells
Marquardt N; Beziat V; Nystrom S; Hengst J; Ivarsson MA; Kekalainen E; Johansson H; Mjosberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaelsson J; Bjorkstrom NK
Article: GUT. 2015;64(3):469-482
Effects of HDV infection and pegylated interferon a treatment on the natural killer cell compartment in chronically infected individuals
Lunemann S; Malone DFG; Grabowski J; Port K; Beziat V; Bremer B; Malmberg K-J; Manns MP; Sandberg JK; Cornberg M; Ljunggren H-G; Wedemeyer H; Bjorkstrom NK
Article: FRONTIERS IN IMMUNOLOGY. 2015;6:507
Polyclonal expansion of NKG2C⁺ NK cells in TAP-deficient patients
Beziat V; Sleiman M; Goodridge JP; Kaarbo M; Liu LL; Rollag H; Ljunggren H-G; Zimmer J; Malmberg K-J
Article: PLOS PATHOGENS. 2015;11(1):e1004622
Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-Borne Encephalitis Virus Infection
Blom K; Braun M; Pakalniene J; Dailidyte L; Beziat V; Lampen MH; Klingstrom J; Lagerqvist N; Kjerstadius T; Michaelsson J; Lindquist L; Ljunggren H-G; Sandberg JK; Mickiene A; Gredmark-Russ S
Journal article: BLOOD. 2014;124(21):1120
Early and Transient Microchimerism Associated with Complete Remission after Adoptively Transferred Haploidentical NK Cells Against High Risk Myelodysplastic Syndrome and Refractory Acute Myeloid Leukemia
Bjorklund AT; Carlsten M; Schaffer M; Liu L; Cooley SA; Miller JS; Watz E; Palma M; Hansson L; Wahlin BE; Mollgard L; Hagglund H; Blomberg P; Ljungman PT; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J
Article: PLOS PATHOGENS. 2014;10(11):e1004521
NK Cell Activation in Human Hantavirus Infection Explained by Virus-Induced IL-15/IL15Rα Expression
Braun M; Bjorkstrom NK; Gupta S; Sundstrom K; Ahlm C; Klingstrom J; Ljunggren H-G
Article: CLINICAL INFECTIOUS DISEASES. 2014;59(8):1130-1132
Increased Risk for Lymphoma Following Hemorrhagic Fever With Renal Syndrome
Klingstrom J; Granath F; Ekbom A; Bjorkstrom NK; Ljunggren H-G
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2014;63(6):627-641
Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation
Theorell J; Gustavsson A-L; Tesi B; Sigmundsson K; Ljunggren H-G; Lundbaeck T; Bryceson YT
Article: JOURNAL OF INFECTIOUS DISEASES. 2014;209(9):1362-1373
Compromised Function of Natural Killer Cells in Acute and Chronic Viral Hepatitis
Lunemann S; Malone DFG; Hengst J; Port K; Grabowski J; Deterding K; Markova A; Bremer B; Schlaphoff V; Cornberg M; Manns MP; Sandberg JK; Ljunggren H-G; Bjorkstrom NK; Wedemeyer H
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(2):90-97
Angiostatic Effects of NK Cell-Derived IFN-γ Counteracted by Tumour Cell Bcl-x_L Expression
Wallin RPA; Sundquist VS; Brakenhielm E; Cao Y; Ljunggren H-G; Grandien A
Journal article: JOURNAL OF IMMUNOLOGY. 2013;190(Supplement_1):117.3
Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response (P1406)
Blom K; Braun M; Ivarsson M; Gonzalez V; Falconer K; Moll M; Ljunggren H-G; Michaelsson J; Sandberg J
Journal article: JOURNAL OF IMMUNOLOGY. 2013;190(Supplement_1):117.9
CD8 T cells express randomly selected KIRs with distinct specificities compared to NK cells (P1418)
Björkström N; Beziat V; Cichocki F; Liu L; Levine J; Larsson S; Koup R; Anderson S; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2013;121(14):2678-2688
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Beziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Bjorklund AT; Retiere C; Sverremark-Ekstrom E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2150-2158
Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D As It Matures from an Effector- to a Memory-Type Response
Blom K; Braun M; Ivarsson MA; Gonzalez VD; Falconer K; Moll M; Ljunggren H-G; Michaelsson J; Sandberg JK
Article: PLOS PATHOGENS. 2013;9(3):e1003272
Hantavirus-infection Confers Resistance to Cytotoxic Lymphocyte-Mediated Apoptosis
Gupta S; Braun M; Tischler ND; Stoltz M; Sundstrom KB; Bjorkstrom NK; Ljunggren H-G; Klingstrom J
Article: BLOOD. 2013;121(8):1345-1356
Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production
Chiang SCC; Theorell J; Entesarian M; Meeths M; Mastafa M; Al-Herz W; Frisk P; Gilmour KC; Ifversen M; Langenskiold C; Machaczka M; Naqvi A; Payne J; Perez-Martinez A; Sabel M; Unal E; Unal S; Winiarski J; Nordenskjold M; Ljunggren H-G; Henter J-I; Bryceson YT
Journal article: ZEITSCHRIFT FUR GASTROENTEROLOGIE. 2013;51(01)
Comprehensive phenotyping of natural killer cells in acute and chronic viral hepatitis
Lunemann S; Malone D; Schlaphoff V; Manns M; Sandberg J; Cornberg M; Ljunggren H; Björkström N; Wedemeyer H
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(6):559-566
NK Cells Inhibit T-bet-deficient, Autoreactive Th17 Cells
Wu W; Shi S; Ljunggren H-G; Cava AL; Van Kaer L; Shi F-D; Liu R
Article: BLOOD. 2012;120(17):3455-3465
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Bjorkstrom NK; Beziat V; Cichocki F; Liu LL; Levine J; Larsson S; Koup RA; Anderson SK; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF INFECTIOUS DISEASES. 2012;205(9):1351-1362
Interferon α-Stimulated Natural Killer Cells From Patients With Acute Hepatitis C Virus (HCV) Infection Recognize HCV-Infected and Uninfected Hepatoma Cells via DNAX accessory molecule-1
Stegmann KA; Bjorkstrom NK; Ciesek S; Lunemann S; Jaroszewicz J; Wiegand J; Malinski P; Dustin LB; Rice CM; Manns MP; Pietschmann T; Cornberg M; Ljunggren H-G; Wedemeyer H
Article: PLOS ONE. 2012;7(1):e29672
Kinome Analysis of Receptor-Induced Phosphorylation in Human Natural Killer Cells
Koenig S; Nimtz M; Scheiter M; Ljunggren H-G; Bryceson YT; Jaensch L
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;74(6):521
2011 Nobel Prize in Physiology or Medicine to three immunologists.
Jonsson R; Ljunggren H-G
Journal article: NATURE REVIEWS IMMUNOLOGY. 2011;11(12):880
Erratum: Organ-specific features of natural killer cells
Shi F-D; Ljunggren H-G; La Cava A; Van Kaer L
Article: BLOOD. 2011;118(22):5783-5793
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Meeths M; Chiang SCC; Wood SM; Entesarian M; Schlums H; Bang B; Nordenskjold E; Bjorklund C; Jakovljevic G; Jazbec J; Hasle H; Holmqvist B-M; Rajic L; Pfeifer S; Rosthoj S; Sabel M; Salmi TT; Stokland T; Winiarski J; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I; Bryceson YT
Article: JOURNAL OF VIROLOGY. 2011;85(19):10252-10260
Longitudinal Analysis of the Human T Cell Response during Acute Hantavirus Infection
Lindgren T; Ahlm C; Mohamed N; Evander M; Ljunggren H-G; Bjorkstrom NK
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3546-3554
Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells
Enqvist M; Nilsonne G; Hammarfjord O; Wallin RPA; Bjoerkstroem NK; Bjornstedt M; Hjerpe A; Ljunggren H-G; Dobra K; Malmberg K-J; Carlsten M
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(7):1913-1923
NKG2D performs two functions in invariant NKT cells: Direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d
Kuylenstierna C; Bjorkstrom NK; Andersson SK; Sahlstrom P; Bosnjak L; Paquin-Proulx D; Malmberg K-J; Ljunggren H-G; Moll M; Sandberg JK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(1):13-21
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
Bjorkstrom NK; Lindgren T; Stoltz M; Fauriat C; Braun M; Evander M; Michaelsson J; Malmberg K-J; Klingstrom J; Ahlm C; Ljunggren H-G
Article: PLOS ONE. 2011;6(11):e27664
Characterization of Natural Killer Cell Phenotype and Function during Recurrent Human HSV-2 Infection
Bjorkstrom NK; Svensson A; Malmberg K-J; Eriksson K; Ljunggren H-G
Article: BLOOD. 2010;116(19):3853-3864
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56^dim NK-cell differentiation uncoupled from NK-cell education
Bjorkstrom NK; Riese P; Heuts F; Andersson S; Fauriat C; Ivarsson MA; Bjorklund AT; Flodstrom-Tullberg M; Michaelsson J; Rottenberg ME; Guzman CA; Ljunggren H-G; Malmberg K-J
Article: LEUKEMIA. 2010;24(9):1607-1616
Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34⁺ blasts in myelodysplastic syndrome
Carlsten M; Baumann BC; Simonsson M; Jadersten M; Forsblom A-M; Hammarstedt C; Bryceson YT; Ljunggren H-G; Hellstrom-Lindberg E; Malmberg K-J
Journal article: ZEITSCHRIFT FUR GASTROENTEROLOGIE. 2010;48(08)
IFN-alpha activated NK cells require DNAM-1 for recognition of infected cells during acute HCV infection
Stegmann K; Björkström N; Wiegand J; Malinski P; Manns M; Ljunggren H; Wedemeyer H
Article: GASTROENTEROLOGY. 2010;138(5):1885-1U68
Interferon-α-Induced TRAIL on Natural Killer Cells Is Associated With Control of Hepatitis C Virus Infection
Stegmann KA; Bjorkstrom NK; Veber H; Ciesek S; Riese P; Wiegand J; Hadem J; Suneetha PV; Jaroszewicz J; Wang C; Schlaphoff V; Fytili P; Cornberg M; Manns MP; Geffers R; Pietschmann T; Guzman CA; Ljunggren H-G; Wedemeyer H
Article: BLOOD. 2010;115(13):2686-2694
NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
Bjorklund AT; Schaffer M; Fauriat C; Ringden O; Remberger M; Hammarstedt C; Barrett AJ; Ljungman P; Ljunggren H-G; Malmberg K-J
Article: PEDIATRIC BLOOD & CANCER. 2010;54(4):563-572
Clinical Presentation of Griscelli Syndrome Type 2 and Spectrum of RAB27A Mutations
Meeths M; Bryceson YT; Rudd E; Zheng C; Wood SM; Ramme K; Beutel K; Hasle H; Heilmann C; Hultenby K; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I
Article: BLOOD. 2010;115(11):2167-2176
Regulation of human NK-cell cytokine and chemokine production by target cell recognition
Fauriat C; Long EO; Ljunggren H-G; Bryceson YT
Article: BLOOD. 2010;115(6):1166-1174
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Fauriat C; Ivarsson MA; Ljunggren H-G; Malmberg K-J; Michaelsson J
Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:353-364
Analysis of the KIR repertoire in human NK cells by flow cytometry.
Björkström NK; Fauriat C; Bryceson YT; Sandberg JK; Ljunggren H-G; Malmberg K-J
Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:335-352
Functional analysis of human NK cells by flow cytometry.
Bryceson YT; Fauriat C; Nunes JM; Wood SM; Björkström NK; Long EO; Ljunggren H-G
Article: HEALTH INFORMATICS JOURNAL. 2009;15(4):305-319
Data extraction from a semi-structured electronic medical record system for outpatients: A model to facilitate the access and use of data for quality control and research
Kristianson KJ; Ljunggren H; Gustafsson LL
Article: JOURNAL OF IMMUNOLOGY. 2009;183(10):6612-6618
Expansion of Functionally Skewed CD56-Negative NK Cells in Chronic Hepatitis C Virus Infection: Correlation with Outcome of Pegylated IFN-α and Ribavirin Treatment
Gonzalez VD; Falconer K; Bjorkstrom NK; Blom KG; Weiland O; Ljunggren H-G; Alaeus A; Sandberg JK
Article: BLOOD. 2009;114(19):4117-4127
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity
Wood SM; Meeths M; Chiang SCC; Bechensteen AG; Boelens JJ; Heilmann C; Horiuchi H; Rosthoj S; Rutynowska O; Winiarski J; Stow JL; Nordenskjold M; Henter J-I; Ljunggren H-G; Bryceson YT
Article: JOURNAL OF IMMUNOLOGY. 2009;183(8):4921-4930
Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells
Carlsten M; Norell H; Bryceson YT; Poschke I; Schedvins K; Liunggren H-G; Kiessling R; Malmberg K-J
Article: BLOOD. 2009;114(13):2657-2666
Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors
Bryceson YT; Ljunggren H-G; Long EO
Article: IMMUNOTHERAPY. 2009;1(5):753-764
Safety analysis of ex vivo-expanded NK and NK-like T cells administered to cancer patients: a Phase I clinical study
Barkholt L; Alici E; Conrad R; Sutlu T; Gilljam M; Stellan B; Christensson B; Guven H; Bjorkstrom NK; Soderdahl G; Cederlund K; Kimby E; Aschan J; Ringden O; Ljunggren H-G; Dilber MS
Article: BLOOD. 2009;114(1):95-104
KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression
Andersson S; Fauriat C; Malmberg J-A; Ljunggren H-G; Malmberg K-J
Article: INFECTION AND IMMUNITY. 2009;77(3):970-976
Transmission of Toxoplasma gondii from Infected Dendritic Cells to Natural Killer Cells
Persson CM; Lambert H; Vutova PP; Dellacasa-Lindberg I; Nederby J; Yagita H; Ljunggren H-G; Grandien A; Barragan A; Chambers BJ
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2008;38(11):2957-2961
Tumor cell recognition by the NK cell activating receptor NKG2D
Bryceson YT; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019
Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype
Fauriat C; Andersson S; Bjorklund AT; Carlsten M; Schaffer M; Bjorkstrom NK; Baumann BC; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2008;181(6):4219-4228
Elevated numbers of FcγRIIIA⁺ (CD16⁺) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
Bjorkstrom NK; Gonzalez VD; Malmberg K-J; Falconer K; Alaeus A; Nowak G; Jorns C; Ericzon B-G; Weiland O; Sandberg JK; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2008;181(5):3057-3066
Cannabinoids affect dendritic cell (DC) potassium channel function and modulate DC T cell stimulatory capacity
Wacnik PW; Luhr KM; Hill RH; Ljunggren H-G; Kristensson K; Svensson M
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):113
Göran Möller 1936-2008.
Jonsson R; Ljunggren H-G; Natvig JB; Orn A
Article: BLOOD. 2008;111(6):3155-3162
Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components
Alici E; Sutlu T; Boejrkstrand B; Gilljam M; Stellan B; Nahi H; Quezada HC; Gahrton G; Ljunggren H-G; Dilber MS
Article: JOURNAL OF MEDICAL GENETICS. 2008;45(3):134-141
Spectrum, and clinical and functional implications of UNC13D mutations in familial haemophagocytic lymphohistiocytosis
Rudd E; Bryceson YT; Zheng C; Edner J; Wood SM; Ramme K; Gavhed S; Gurgey A; Hellebostad M; Bechensteen AG; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I
Article: CELLULAR MICROBIOLOGY. 2008;10(2):426-436
IFN-γ production dominates the early human natural killer cell response to Coxsackievirus infection
Huhn MH; Hultcrantz M; Lind K; Ljunggren H-G; Malmberg K-J; Flodstrom-Tullberg M
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74
Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
Gonzalez VD; Bjorkstroem NK; Malmberg K-J; Moll M; Kuylenstierna C; Michalsson J; Ljunggren H-G; Sandberg JK
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;83(1):56-63
Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells
Wagner CS; Walther-Jallow L; Buentke E; Ljunggren H-G; Achour A; Chambers BJ
Article: EXPERIMENTAL HEMATOLOGY. 2007;35(12):1839-1846
Anti-myeloma activity of endogenous and adoptively transferred activated natural killer cells in experimental multiple myeloma model
Alici E; Konstantinidis KV; Sutlu T; Aints A; Gahrton G; Ljunggren H-G; Dilber MS
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;373(3):695-705
Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1
Wagner CS; Roelle A; Cosman D; Ljunggren H-G; Berndt KD; Achour A
Article: CANCER RESEARCH. 2007;67(18):8450-8455
Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination
Chambers B; Grufman P; Fredriksson V; Andersson K; Roseboom M; Laban S; Camps M; Wolpert EZ; Wiertz EJHJ; Offringa R; Ljunggren H-G; van Hall T
Article: BLOOD. 2007;110(6):1906-1915
Defective cytotoxic lymphocyte degranulation in syntaxin-11-deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients
Bryceson YT; Rudd E; Zheng C; Edner J; Ma D; Wood SM; Bechensteen AG; Boelens JJ; Celkan T; Farah RA; Hultenby K; Winiarski J; Roche PA; Nordenskjold M; Henter J-I; Long EO; Ljunggren H-G
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2007;66(2‐3):105
EDITORIAL
Jonsson R; Ljunggren H; Rizzo LV
Article: JOURNAL OF NEUROIMMUNOLOGY. 2007;186(1-2):19-26
Aggravation of experimental autoimmune neuritis in TNF-α receptor 1 deficient mice
Lu M-O; Duan R-S; Quezada HC; Chen Z-G; Mix E; Jin T; Yang X; Ljunggren H-G; Zhu J
Article: JOURNAL OF IMMUNOLOGY. 2007;178(8):5018-5027
Severe defect in thymic development in an insertional mutant mouse model
Assarsson E; Chambers BJ; Hogstrand K; Berntman E; Lundmark C; Fedorova L; Imreh S; Grandien A; Cardell S; Rozell B; Ljunggren H-G
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2007;65(4):353-361
NK cell-mediated destruction of influenza A virus-infected peripheral but not central neurones
Backstrom E; Ljunggren H-G; Kristensson K
Article: CANCER RESEARCH. 2007;67(3):1317-1325
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
Carlsten M; Bjorkstrom NK; Norell H; Bryceson Y; van Hall T; Baumann BC; Hanson M; Schedvins K; Kiessling R; Ljunggren H-G; Malmberg KJ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2006;80(6):1345-1353
Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms
Joshi PS; Liu J-Q; Wang Y; Chang X; Richards J; Assarsson E; Shi F-D; Ljunggren H-G; Bai X-F
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2006;64(3):171
Dear readers of Scandinavian Journal of Immunology and ECI2006 attendees
Jonsson R; Ljunggren H
Article: FASEB JOURNAL. 2006;20(7):896-905
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system
Huang D; Shi F-D; Jung S; Pien GC; Wang J; Salazar-Mather TP; He TT; Weaver JT; Ljunggren H-G; Biron CA; Littman DR; Ransohoff RM
Article: LEUKEMIA. 2006;20(5):833-839
Evaluation of ex vivo expanded human NK cells on antileukemia activity in SCID-beige mice
Guimaraes F; Guven H; Donati D; Christensson B; Ljunggren HG; Bejarano MT; Dilber MS
Article: NATURE MEDICINE. 2006;12(4):417-424
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants
van Hall T; Wolpert EZ; van Veelen P; Laban S; van der Veer M; Roseboom M; Bres S; Grufman P; de Ru A; Meiring H; de Jong A; Franken K; Teixeira A; Valentijn R; Drijfhout JW; Koning F; Camps M; Ossendorp F; Kärre K; Ljunggren HG; Melief CJM; Offringa R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(13):8950-8957
Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules - Prominent role of a single arginine residue in human leukocyte antigen-A2
Thilo C; Berglund P; Applequist SE; Yewdell JW; Ljunggren HG; Achour A
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396
Structural basis of the differential stability and receptor specificity of H-2D^b in complex with murine versus human β₂-microglobulin
Achour A; Michaëlsson T; Harris RA; Ljunggren HG; Kärre M; Schneider G; Sandalova T
Article: BLOOD. 2006;107(1):159-166
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
Bryceson YT; March ME; Ljunggren HG; Long EO
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093
Expression, refolding and crystallization of murine MHC class IH-2D^b in complex with human β₂-microglobulin
Sandalova T; Michaëlsson J; Harris RA; Ljunggren HG; Kärre K; Schneider G; Achour A
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;62(5):437-444
Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance
Alenmyr L; Matheu V; Uller L; Greiff L; Malm-Erjefält M; Ljunggren HG; Persson CGA; Korsgren M
Article: EXPERIMENTAL HEMATOLOGY. 2005;33(11):1320-1328
Efficient gene transfer into primary human natural killer cells by retroviral transduction
Guven H; Konstantinidis KV; Alici E; Aints A; Abedi-Valugerdi M; Christensson B; Ljunggren HG; Dilber MS
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;202(7):1001-1012
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
Bryceson YT; March ME; Barber DF; Ljunggren HG; Long EO
Article: JOURNAL OF IMMUNOLOGY. 2005;175(6):3882-3891
Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin
Applequist SE; Rollman E; Wareing MA; Lidén M; Rozell B; Hinkula J; Ljunggren HG
Article: JOURNAL OF NEUROVIROLOGY. 2005;11(4):395-402
Effects on synaptic activity in cultured hippocampal neurons by influenza A viral proteins
Brask J; Chauhan A; Hill RH; Ljunggren HG; Kristensson K
Article: TRENDS IN IMMUNOLOGY. 2005;26(7):347-349
Development and function of CD1d-restricted NKT cells: influence of sphingolipids, SAP and sex
Sandberg JK; Ljunggren HG
Article: EXPERIMENTAL HEMATOLOGY. 2005;33(2):159-164
Targeting IL-2 to the endoplasmic reticulum confines autocrine growth stimulation to NK-92 cells
Konstantinidis KV; Alici E; Aints A; Christensson B; Ljunggren HG; Dilber MS
Article: NEUROBIOLOGY OF DISEASE. 2004;17(2):171-178
IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice
Chen ZG; Duan RS; Q HC; Wu QY; Mix E; Winblad B; Ljunggren HG; Zhu J
Article: TRANSPLANTATION. 2004;78(7):1081-1085
Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation
Schaffer M; Malmberg KJ; Ringdén O; Ljunggren HG; Remberger M
Article: SCIENCE. 2004;305(5687):1153-1157
Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling
West MA; Wallin RPA; Matthews SP; Svensson HG; Zaru R; Ljunggren HG; Prescott AR; Watts C
Article: JOURNAL OF IMMUNOLOGY. 2004;173(1):174-180
NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions
Assarsson E; Kambayashi T; Schatzle JD; Cramer SO; von Bonin A; Jensen PE; Ljunggren HG; Chambers BJ
Article: JOURNAL OF VIROLOGY. 2004;78(9):4776-4782
Scrapie protein degradation by cysteine proteases in CD11c⁺ dendritic cells and GT1-1 neuronal cells
Luhr KM; Nordström EK; Löw P; Ljunggren HG; Taraboulos A; Kristensson K
Article: JOURNAL OF IMMUNOLOGY. 2004;172(9):5504-5511
Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition
Velloso LM; Michaëlsson J; Ljunggren HG; Schneider G; Achour A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(14):4972-4977
Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-κB inhibition
Lind MH; Rozell B; Wallin RPA; van Hogerlinden M; Ljunggren HG; Toftgård R; Sur I
Journal article: ATHEROSCLEROSIS PLUS. 2004;5(1):42
W07.183 CD1d-dependent activation of NKT cells aggravates atherosclerosis
Tupin E; Nicoletti A; Elhage R; Rudling M; Ljunggren H; Hansson G; Berne GP
Article: BRAIN BEHAVIOR AND IMMUNITY. 2004;18(2):175-185
Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis
Chen ZG; Yu S; Concha HQ; Zhu Y; Mix E; Winblad B; Ljunggren HG; Zhu J
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2004;199(3):417-422
CD1d-dependent activation of NKT cells aggravates atherosclerosis
Tupin E; Nicoletti A; Elhage R; Rudling M; Ljunggren HG; Hansson GK; Berne GP
Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2004;63(2):120-128
Increased susceptibility to experimental autoimmune neuritis after upregulation of the autoreactive T cell response to peripheral myelin antigen in apolipoprotein E-deficient mice
Yu S; Duan RS; Chen ZG; Quezada HC; Bao L; Nennesmo I; Zhu SW; Winblad B; Ljunggren HG; Zhu J
Article: JOURNAL OF NEUROIMMUNOLOGY. 2004;146(1-2):33-38
Reduced susceptibility to kainic acid-induced excitoxicity in T-cell deficient CD4/CD8(-/-) and middle-aged C57BL/6 mice
Chen ZG; Ljunggren HG; Zhu SW; Winblad B; Zhu J
Article: JOURNAL OF IMMUNOLOGY. 2004;172(1):123-129
NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy
Hayakawa Y; Screpanti V; Yagita H; Grandien A; Ljunggren HG; Smyth MJ; Chambers BJ
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(10):2727-2735
Regulation of perforin-independent NK cell-mediated cytotoxicity
Wallin RPA; Screpanti V; Michaëlsson J; Grandien A; Ljunggren HG
Article: LEUKEMIA. 2003;17(10):1973-1980
Expansion of natural killer (NK) and natural killer-like T (NKT)-cell populations derived from patients with B-chronic lymphocytic leukemia (B-CLL): a potential source for cellular immunotherapy
Guven H; Gilljam M; Chambers BJ; Ljunggren HG; Christensson B; Kimby E; Dilber MS
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(39):37730-37735
The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family
Kaiser L; Grönlund H; Sandalova T; Ljunggren HG; van Hage-Hamsten M; Achour A; Schneider G
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2003;132(1):25-26
Three-dimensional structure of Fel d 1, the major allergen in cat
Kaiser L; Grönlund H; Sandalova T; Ljunggren HG; Achour A; Schneider G; van Hage-Hamsten M
Article: CARDIOVASCULAR RESEARCH. 2003;59(1):234-240
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice
Elhage R; Jawien J; Rudling M; Ljunggren HG; Takeda K; Akira S; Bayard F; Hansson GK
Article: IMMUNOLOGY. 2003;109(3):384-391
Efficient antigen presentation of soluble, but not particulate, antigen in the absence of Wiskott-Aldrich syndrome protein
Westerberg L; Wallin RPA; Greicius G; Hans-Gustaf L; Severinson E
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2003;59(Pt 6):1103-1105
Production, crystallization and preliminary crystallographic study of the major cat allergen Fel d I
Kaiser L; Grönlund H; Sandalova T; Ljunggren HG; Schneider G; van Hage-Hamsten M; Achour A
Article: JOURNAL OF IMMUNOLOGY. 2003;170(5):2399-2408
Memory CD8⁺ T cells provide an early source of IFN-γ
Kambayashi T; Assarsson E; Lukacher AE; Ljunggren HG; Jensen PE
Article: NEUROBIOLOGY OF DISEASE. 2003;12(1):73-81
Exogenous soluble tumor necrosis factor receptor type I ameliorates murine experimental autoimmune neuritis
Bao L; Lindgren JU; Zhu Y; Ljunggren HG; Zhu J
Article: VIRAL IMMUNOLOGY. 2003;16(3):415-423
Invasion and persistence of the neuroadapted influenza virus A/WSN/33 in the mouse olfactory system
Aronsson F; Robertson B; Ljunggren HG; Kristensson K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(1):92-100
Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions
Backström E; Chambers BJ; Ho EL; Naidenko OV; Mariotti R; Fremont DH; Yokoyama WM; Kristensson K; Ljunggren HG
Article: JOURNAL OF VIROLOGY. 2002;76(23):12259-12264
Processing and degradation of exogenous prion protein by CD11c⁺ myeloid dendritic cells in vitro
Luhr KM; Wallin RPA; Ljunggren HG; Löw P; Taraboulos A; Kristensson K
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2002;119(4):850-857
Natural killer and dendritic cell contact in lesional atopic dermatitis skin -: Malassezia-influenced cell interaction
Buentke E; Heffler LC; Wilson JL; Wallin RPA; Löfman C; Chambers BJ; Ljunggren HG; Scheynius A
Article: BRAIN PATHOLOGY. 2002;12(4):420-429
The critical role of IL-12p40 in initiating, enhancing, and perpetuating pathogenic events in murine experimental autoimmune neuritis
Bao L; Lindgren JU; van der Meide P; Zhu SW; Ljunggren HG; Zhu J
Article: EXPERIMENTAL NEUROLOGY. 2002;177(1):314-320
CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis
Zhu Y; Bao L; Zhu SW; Chen ZG; van der Meide P; Nennesmo I; Winblad B; Ljunggren HG; Zhu J
Article: INTERNATIONAL IMMUNOLOGY. 2002;14(9):1065-1074
Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines
Applequist SE; Wallin RPA; Ljunggren HG
Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2002;61(7):614-622
Neutralizing antibodies to IL-18 ameliorate experimental autoimmune neuritis by counter-regulation of autoreactive Th1 responses to peripheral myelin antigen
Yu S; Chen ZG; Mix E; Zhu SW; Winblad B; Ljunggren HG; Zhu J
Article: BRAIN RESEARCH. 2002;931(2):135-145
Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice
Chen ZG; Ljunggren HG; Bogdanovic N; Nennesmo I; Winblad B; Zhu J
Article: CELL TRANSPLANTATION. 2002;11(7):715-720
Co-stimulatory molecules in islet xenotransplantation: CTLA4Ig treatment in CD40 ligand-deficient mice
Benda B; Ljunggren HG; Peach R; Sandberg JO; Korsgren O
Article: JOURNAL OF NEUROVIROLOGY. 2002;8(SUPPL 1):30-31
Viral infections & autoimmune disease
Backstrom E; Chambers B; Kristensson K; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2001;167(12):6706-6710
Cutting edge:: Regulation of CD8⁺ T cell proliferation by 2B4/CD48 interactions
Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2001;70(6):903-910
cAMP-elevating agents suppress dendritic cell function
Kambayashi T; Wallin RPA; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(11):3248-3254
IL-2 down-regulates the expression of TCR and TCR-associated surface molecules on CD8⁺ T cells
Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2001;31(10):1583-1593
The allergenic yeast Malassezia furfur induces maturation of human dendritic cells
Buentke E; Heffler LC; Wallin RPA; Löfman C; Ljunggren HG; Scheynius A
Article: HUMAN IMMUNOLOGY. 2001;62(10):1092-1098
A new method for in vitro expansion of cytotoxic human CD3^-CD56⁺ natural killer cells
Carlens S; Gilljam M; Chambers BJ; Aschan J; Guven H; Ljunggren HG; Christensson B; Dilber MS
Article: INFECTION AND IMMUNITY. 2001;69(9):5726-5735
In vivo activation of dendritic cells and T cells during Salmonella enterica serovar typhimurium infection
Yrlid U; Svensson M; Håkansson A; Chambers BJ; Ljunggren HG; Wick MJ
Article: JOURNAL OF IMMUNOLOGY. 2001;167(5):3000-3006
Control of the autoimmune response by type 2 nitric oxide synthase
Shi FD; Flodström M; Kim SH; Pakala S; Cleary M; Ljunggren HG; Sarvetnick N
Article: JOURNAL OF IMMUNOLOGY. 2001;167(4):2068-2073
A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells
Screpanti V; Wallin RPA; Ljunggren HG; Grandien A
Article: EXPERIMENTAL NEUROLOGY. 2001;169(2):472-478
Suppression of autoimmune neuritis in IFN-γ receptor-deficient mice
Zhu Y; Ljunggren HG; Mix E; Li HL; van der Meide P; Elhassan AM; Winblad B; Zhu J
Article: JOURNAL OF IMMUNOLOGY. 2001;166(10):6430-6436
Anti-CTLA-4 antibody treatment triggers determinant spreading and enhances murine myasthenia gravis
Wang HB; Shi FD; Li HL; Chambers BJ; Link H; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(5):1523-1530
Expression of the DX5 antigen on CD8⁺ T cells is associated with activation and subsequent cell death or memory during influenza virus infection
Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: JOURNAL OF NEUROIMMUNOLOGY. 2001;115(1-2):111-117
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade enhances incidence and severity of experimental autoimmune neuritis in resistant mice
Zhu J; Zou LP; Zhu SW; Mix E; Shi FD; Wang HB; Volkmann I; Winblad B; Schalling M; Ljunggren HG
Article: JOURNAL OF NEUROVIROLOGY. 2001;7(2):117-124
Persistence of the influenza A/WSN/33 virus RNA at midbrain levels of immunodefective mice
Aronsson F; Karlsson H; Ljunggren HG; Kristensson K
Article: JOURNAL OF NEUROIMMUNOLOGY. 2001;114(1-2):114-121
CD28-B7 costimulation: a critical role for initiation and development of experimental autoimmune neuritis in C57BL/6 mice
Zhu Y; Ljunggren HG; Mix E; Li HL; van der Meide P; Elhassan AM; Winblad B; Zhu J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875
Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro
Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
Article: INTERNATIONAL JOURNAL OF CANCER. 2001;91(3):373-378
Soluble MHC class I molecules induce cellular death in a CD8⁺ T-cell hybridoma tumor model
Kambayashi T; Ichihara F; Jensen PE; Ljunggren HG
Article: INTERNATIONAL IMMUNOLOGY. 2001;13(1):23-29
Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP)
Paulsson KM; Anderson PO; Chen SW; Sjögren HO; Ljunggren HG; Wang P; Li SL
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(1):225-232
Disruption of the IL-1β gene diminishes acetylcholine receptor-induced immune responses in a murine model of myasthenia gravis
Huang DR; Shi FD; Giscombe R; Zhou YH; Ljunggren HG; Lefvert AK
Article: MOLECULAR CANCER RESEARCH. 2001;12(1):51-60
Differentiation of Ly49s-positive or -negative natural killer cells is inhibited by anti-H-2^b monoclonal antibodies acting at the level of bone marrow progenitors from B6 mice
Delfino DV; Salcedo M; Di Marco B; Ayroldi E; Nocentini G; Bruscoli S; Brunetti L; Ljunggren HG; Riccardi C
Article: NATURE MEDICINE. 2000;6(12):1348-1354
Efficient presentation of exogenous antigen by liver endothelial cells to CD8⁺ T cells results in antigen-specific T-cell tolerance
Limmer A; Ohl J; Kurts C; Ljunggren HG; Reiss Y; Groettrup M; Momburg F; Arnold B; Knolle PA
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2000;62(5):717-721
P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice
Zou LP; Ljunggren HG; Levi M; Nennesmo I; Wahren B; Mix E; Winblad B; Schalling M; Zhu J
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4895-4900
Direct NK cell-mediated lysis of syngenic dorsal root ganglia neurons in vitro
Backström E; Chambers BJ; Kristensson K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4964-4969
Emergence of CD8⁺ T cells expressing NK cell receptors in influenza A virus-infected mice
Kambayashi T; Assarsson E; Michaëlsson J; Berglund P; Diehl AP; Chambers BJ; Ljunggren HG
Article: INTERNATIONAL IMMUNOLOGY. 2000;12(10):1381-1388
Tumor necrosis factor receptor-1 is critically involved in the development of experimental autoimmune myasthenia gravis
Wang HB; Li H; Shi FD; Chambers BJ; Link H; Ljunggren HG
Journal article: BLOOD. 2000;96(7):2568-2573
Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10
Cervenak L; Morbidelli L; Donati D; Donnini S; Kambayashi T; Wilson JL; Axelson H; Castaños-Velez E; Ljunggren H-G; De Waal Malefyt R; Granger HJ; Ziche M; Bejarano MT
Article: BLOOD. 2000;96(7):2568-2573
Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10
Cervenak L; Morbidelli L; Donati D; Donnini S; Kambayashi T; Wilson JL; Axelson H; Castaños-Velez E; Ljunggren HG; Malefyt RD; Granger HJ; Ziche M; Bejarano MT
Article: JOURNAL OF IMMUNOLOGY. 2000;165(7):3673-3679
CD8⁺ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo
Assarsson E; Kambayashi T; Sandberg JK; Hong S; Taniguchi M; Van Kaer L; Ljunggren HG; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2000;165(6):3099-3104
IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-γ by NK cells
Shi FD; Takeda K; Akira S; Sarvetnick N; Ljunggren HG
Article: NATURE IMMUNOLOGY. 2000;1(3):245-251
Natural killer cells determine the out-come of B cell-mediated autoimmunity
Shi FD; Wang HB; Li HL; Hong S; Taniguchi M; Link H; Van Kaer L; Ljunggren HG
Article: NATURE IMMUNOLOGY. 2000;1(3):234-238
Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
Garbi N; Tan P; Diehl AD; Chambers BJ; Ljunggren HG; Momburg F; Hämmerling GJ
Article: CLINICAL IMMUNOLOGY. 2000;95(2):156-162
Role for interferon-γ in rat strains with different susceptibility to experimental autoimmune myasthenia gravis
Wang HB; Shi FD; Li HL; van der Meide PH; Ljunggren HG; Link H
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(4):1094-1101
Role of Qa-1^b-binding receptors in the specificity of developing NK cells
Salcedo M; Colucci F; Dyson PJ; Cotterill LA; Lemonnier FA; Kourilsky P; Di Santo JP; Ljunggren HG; Abastado JP
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2000;51(3):219-223
β₂-microglobulin/CD8-/- mice reveal significant role for CD8⁺ T cells in graft rejection responses in β₂-microglobulin -/- mice
Freland S; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1999;163(12):6365-6370
Targeting of human dendritic cells by autologous NK cells
Wilson JL; Heffler LC; Charo J; Scheynius A; Bejarano MT; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1999;163(8):4207-4212
NK cell triggering by the human costimulatory molecules CD80 and CD86
Wilson JL; Charo J; Martín-Fontecha A; Dellabona P; Casorati G; Chambers BJ; Kiessling R; Bejarano MT; Ljunggren HG
Article: JOURNAL OF NEUROVIROLOGY. 1999;5(4):355-362
Selective targeting of habenular, thalamic midline and monoaminergic brainstem neurons by neurotropic influenza A virus in mice
Mori I; Diehl AD; Chauhan A; Ljunggren HG; Kristensson K
Article: JOURNAL OF IMMUNOLOGY. 1999;162(10):5757-5763
Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: Identification of regulatory cells
Shi FD; Li HL; Wang HB; Bai XF; van der Meide PH; Link H; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1999;162(10):5910-5916
Triggering of murine NK cells by CD40 and CD86 (B7-2)
Martín-Fontecha A; Assarsson E; Carbone E; Kärre K; Ljunggren HG
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1999;189(3):553-562
Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice
Korsgren M; Persson CGA; Sundler F; Bjerke T; Hansson T; Chambers BJ; Hong SM; Van Kaer L; Ljunggren HG; Korsgren O
Article: JOURNAL OF NEUROIMMUNOLOGY. 1999;94(1-2):196-203
Induction of experimental autoimmune neuritis in CD4^-8^- C57BL/6J mice
Zhu J; Nennesmo I; Deng GM; Levi M; Wahren B; Diab A; Mix E; Zhou JN; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1998;161(12):6475-6479
MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells
Andersson M; Freland S; Johansson MH; Wallin R; Sandberg JK; Chambers BJ; Christensson B; Lendahl U; Lemieux S; Salcedo M; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(12):4356-4361
The Qa-1^b molecule binds to a large subpopulation of murine NK cells
Salcedo M; Bousso P; Ljunggren HG; Kourilsky P; Abastado JP
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(11):3587-3593
Differential requirements for CD28 and CD40 ligand in the induction of experimental autoimmune myasthenia gravis
Shi FD; He B; Li HL; Matusevicius D; Link H; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(4):1315-1321
Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice
Salcedo M; Andersson M; Lemieux S; Van Kaer L; Chambers BJ; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1998;160(2):572-579
Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice
Freland S; Chambers BJ; Andersson M; Van Kaer L; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1997;159(11):5364-5371
TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells
Liu TM; Chambers B; Diehl AD; Van Kaer L; Jondal M; Ljunggren HG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(21):11496-11501
Generation of CD8(+) T cells specific for transporter associated with antigen processing deficient cells
Wolpert EZ; Petersson M; Chambers BJ; Sandberg JK; Kiessling R; Ljunggren HG; Karre K
Article: JOURNAL OF IMMUNOLOGY. 1997;159(7):3189-3194
NK cell receptor calibration - Effects of MHC class I induction on killing by Ly49A(high) and Ly49A(low) NK cells
OlssonAlheim MY; Salcedo M; Ljunggren HG; Karre K; Sentman CL
Article: JOURNAL OF IMMUNOLOGY. 1997;159(7):3195-3202
Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10
SalazarOnfray F; Charo J; Petersson M; Freland S; Noffz G; Qin ZH; Blankenstein T; Ljunggren HG; Kiessling R
Article: JOURNAL OF MEDICAL VIROLOGY. 1997;52(4):362-369
Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice
Urbanska EM; Chambers BJ; Ljunggren HG; Norrby E; Kristensson K
Journal article: CLINICAL NEUROLOGY AND NEUROSURGERY. 1997;99:s29
O-9-129 Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression
Yamasaki T; Akiyamna Y; Fukuda M; Kimura Y; Uemura T; Moritake K; Ljunggren HG; Karre K; Klein G
Journal article: IMMUNOLOGY LETTERS. 1997;56:386
The role of natural killer (NK) cells in regulating antigen presenting cells
Chambers BJ; Wilson JL; Salcedo MS; Ljunggren HG
Journal article: IMMUNOLOGY LETTERS. 1997;56:243
Constitutive macropinocytosis allows TAP-dependent class I MHC presentation of exogenous soluble antigen by bone-marrow derived dendritic cells
Norbury CC; Chambers BJ; Prescott AR; Ljunggren HG; Watts C
Journal article: IMMUNOLOGY LETTERS. 1997;56:385
Altered expression of Ly49 inhibitory receptors on NK cells from MHC class I deficient mice
Salcedo M; Diehl AD; Olsson-Alheim MY; Sundbäck J; Van Kaer L; Kärre K; Ljunggren HG
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1997;45(5):527-533
MHC class I presentation of live and heat-inactivated Sendai virus antigen in T2K(b) cells depends on an intracellular compartment with endosomal characteristics
Liu T; Zhou X; AbdelMotal UM; Ljunggren HG; Jondal M
Article: JOURNAL OF IMMUNOLOGY. 1997;158(7):3174-3180
Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice
Salcedo M; Diehl AD; OlssonAlheim MY; Sundback J; VanKaer L; Karre K; Ljunggren HG
Article: TRANSPLANTATION. 1997;63(1):119-123
Major histocompatibility complex class I-independent killing of xenogenic targets by rat allospecific natural killer cells
Torgersen KM; Salcedo M; Vaage JT; Naper C; Rolstad B; Ljunggren HG; Hoglund P
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(1):280-288
Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells
Norbury CC; Chambers BJ; Prescott AR; Ljunggren HG; Watts C
Article: IMMUNOLOGY LETTERS. 1996;54(1):31-35
External glycopeptide binding to MHC class-I in relation to expression of TAP transporters, beta 2-microglobulin and to pH
AbdelMotal UM; Dahmen J; Liu TM; Ljunggren HG; Jondal M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(40):24830-24835
Binding of H-2K(b)-specific peptides to TAP and major histocompatibility complex class I in microsomes from wild-type, TAP1, and beta(2)-microglobulin mutant mice
Wang P; Raynoschek C; Svensson K; Ljunggren HG
Article: IMMUNITY. 1996;5(4):311-317
Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)
Chambers BJ; Salcedo M; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(8):1844-1850
Chemically induced sarcomas from nude mice are more immunogenic than similar sarcomas from congenic normal mice
Svane IM; Engel AM; Nielsen MB; Ljunggren HG; Rygaard J; Werdelin O
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;67(3):365-371
Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression
Yamasaki T; Akiyama Y; Fukuda M; Kimura Y; Moritake K; Kikuchi H; Ljunggren HG; Karre K; Klein G
Article: TRANSPLANTATION. 1996;61(9):1313-1320
Xenograft rejection of porcine islet-like cell clusters in normal and natural killer cell-depleted mice
KarlssonParra A; Ridderstad A; Wallgren AC; Moller E; Ljunggren HG; Korsgren O
Journal article: HUMAN IMMUNOLOGY. 1996;47(1-2):110
P599 Reactivity and specificity of CD8+ T cells in MHC class I deficient mice
Ljunggren H-G; Chambers B; Freland S; Glas R; Sandberg J; Kärre K; Tonegawa S; Ploegh HL; Van Kaer L
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(2):288-293
TAP1-deficient mice select a CD8(+) T cell repertoire that displays both diversity and peptide specificity
Sandberg JK; Chambers BJ; VanKaer L; Karre K; Ljunggren HG
Article: TRANSPLANTATION. 1995;60(3):281-286
NATURAL-KILLER-CELL INTERACTION WITH MURINE ALLOGENEIC MHC CLASS-I MOLECULES
SALCEDO M; HOGLUND P; LJUNGGREN HG
Article: MOLECULAR IMMUNOLOGY. 1995;32(11):789-794
ALTERED MHC CLASS-I PRESENTED PEPTIDE REPERTOIRE IS NOT SUFFICIENT TO INDUCE NK CELL-MEDIATED F-1-HYBRID RESISTANCE
SALCEDO M; HOGLUND P; ACHOUR A; THORPE CJ; LJUNGGREN HG
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1995;42(1):66-75
CHARACTERIZATION OF TAP-INDEPENDENT AND BREFELDIN A-RESISTANT PRESENTATION OF SENDAI VIRUS-ANTIGEN TO CD8(+) CYTOTOXIC T-LYMPHOCYTES
ZHOU X; LIU T; FRANKSSON L; LEDERER E; LJUNGGREN HG; JONDAL M
Article: INTERNATIONAL IMMUNOLOGY. 1995;7(6):975-984
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice.
Ljunggren HG; Van Kaer L; Sabatine MS; Auchincloss H; Tonegawa S; Ploegh HL
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1995;25(5):1286-1291
INHIBITION OF NATURAL-KILLER CELL-MEDIATED BONE-MARROW GRAFT-REJECTION BY ALLOGENEIC MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I, BUT NOT CLASS-II MOLECULES
OHLEN C; HOGLUND P; SENTMAN CL; CARBONE E; LJUNGGREN HG; KOLLER B; KARRE K
Article: CANCER RESEARCH. 1995;55(9):1911-1916
REJECTION OF TUMORS IN MICE WITH SEVERE COMBINED IMMUNODEFICIENCY SYNDROME DETERMINED BY THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I EXPRESSION ON THE GRAFT
GLAS R; WALDENSTROM M; HOGLUND P; KLEIN G; KARRE K; LJUNGGREN HG
Article: JOURNAL OF IMMUNOLOGY. 1995;154(7):3147-3155
HEAT-INACTIVATED SENDAI-VIRUS CAN ENTER MULTIPLE MHC CLASS-I PROCESSING PATHWAYS AND GENERATE CYTOTOXIC T-LYMPHOCYTE RESPONSES IN-VIVO
LIU TM; ZHOU XZ; ORVELL C; LEDERER E; LJUNGGREN HG; JONDAL M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;181(3):1111-1122
PEPTIDE INFLUENCES THE FOLDING AND INTRACELLULAR-TRANSPORT OF FREE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I HEAVY-CHAINS
MACHOLD RP; ANDREE S; VANKAER L; LJUNGGREN HG; PLOEGH HL
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1995;25(1):174-178
Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice.
Ljunggren HG; Van Kaer L; Ashton-Rickardt PG; Tonegawa S; Ploegh HL
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1994;24(8):1863-1868
PRESENTATION OF VIRAL-ANTIGENS RESTRICTED BY H-2K(B), D-B OR K-D IN PROTEASOME SUBUNIT LMP2-DEFICIENT AND LMP7-DEFICIENT CELLS
ZHOU XZ; MOMBURG F; LIU TM; MOTAL UMA; JONDAL M; HAMMERLING GJ; LJUNGGREN HG
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1994;91(14):6520-6524
ALTERED NATURAL-KILLER-CELL REPERTOIRE IN TAP-1 MUTANT MICE
LJUNGGREN HG; VANKAER L; PLOEGH HL; TONEGAWA S
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1994;91(14):6525-6528
POSITIVE SELECTION OF SELFREACTIVE AND ALLOREACTIVE CD8+ T-CELLS IN TAP-1 MUTANT MICE
ALDRICH CJ; LJUNGGREN HG; VANKAER L; ASHTONRICKARDT PG; TONEGAWA S; FORMAN J
Journal article: INTERNATIONAL IMMUNOLOGY. 1994;6(7):1061-1070
PERIPHERAL LYMPHOID DEVELOPMENT AND FUNCTION IN TCR MUTANT MICE
MOMBAERTS P; MIZOGUCHI E; LJUNGGREN HG; IACOMINI J; ISHIKAWA H; WANG L; GRUSBY MJ; GLIMCHER LH; WINN HJ; BHAN AK; TONEGAWA S
Journal article: JOURNAL OF IMMUNOLOGY. 1994;152(4):1702-1708
RESISTANCE TO NATURAL-KILLER-CELL LYSIS CONFERRED BY TAP1/2 GENES IN HUMAN ANTIGEN-PROCESSING MUTANT-CELLS
SALCEDO M; MOMBURG F; HAMMERLING GJ; LJUNGGREN HG
Journal article: VIROLOGY. 1994;198(2):714-716
T-CELL SUBSETS INVOLVED IN IMMUNITY AGAINST POLYOMA VIRUS-INDUCED TUMORS
LJUNGGREN G; LJUNGGREN HG; DALIANIS T
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1993;23(8):1802-1808
ANTIGEN-PROCESSING MUTANT T2 CELLS PRESENT VIRAL-ANTIGEN RESTRICTED THROUGH H-2KB
ZHOU XZ; GLAS R; LIU TM; LJUNGGREN HG; JONDAL M
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1993;23(8):1796-1801
TAP2-DEFECTIVE RMA-S CELLS PRESENT SENDAI VIRUS-ANTIGEN TO CYTOTOXIC T-LYMPHOCYTES
ZHOU XZ; GLAS R; MOMBURG F; HAMMERLING GJ; JONDAL M; LJUNGGREN HG
Journal article: INTERNATIONAL JOURNAL OF CANCER. 1993;54(6):992-995
IDENTIFICATION OF H-2KB-BINDING, DB-BINDING AND DD-BINDING PEPTIDES DERIVED FROM AMINO-ACID-SEQUENCES OF POLYOMA VIRUS-T ANTIGENS
REINHOLDSSONLJUNGGREN G; FRANKSSON L; DALIANIS T; LJUNGGREN HG
Journal article: INTERNATIONAL JOURNAL OF CANCER. 1993;54(3):518-523
GENERATION AND CONTROL OF METASTASIS IN EXPERIMENTAL TUMOR SYSTEMS - INHIBITION OF EXPERIMENTAL METASTASES BY A TILORONE ANALOG
ALGARRA I; PEREZ M; HOGLUND P; GAFORIO JJ; LJUNGGREN HG; GARRIDO F
Journal article: JOURNAL OF NEUROSURGERY. 1993;78(4):619-629
ROLE OF HISTOCOMPATIBILITY ANTIGEN GENE AND PROTOONCOGENE EXPRESSIONS IN INTRACEREBRAL TUMORIGENICITY OF MOUSE NEUROBLASTOMA
YAMASAKI T; KLEIN G; LJUNGGREN HG; KARRE K; MORITAKE K; PAINE JT; KIKUCHI H
Journal article: EUROPEAN JOURNAL OF CANCER. 1993;29A(2):238-241
MHC CLASS-I EXPRESSION ON PRELYMPHOMATOUS AND LYMPHOMATOUS B-CELLS IS NOT INHIBITED BY AN E-MU-MYC TRANSGENE
ALGARRA I; SILVA S; LJUNGGREN HG
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1992;89(23):11381-11385
MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I-SPECIFIC AND CLASS-I-RESTRICTED KILLING OF BETA(2)-MICROGLOBULIN-DEFICIENT CELLS BY CD8+ CYTOTOXIC LYMPHOCYTES-T
GLAS R; FRANKSSON L; OHLEN C; HOGLUND P; KOLLER B; LJUNGGREN HG; KARRE K
Journal article: INTERNATIONAL JOURNAL OF CANCER. 1992;52(1):153-158
EFFECT OF MHC CLASS-I TRANSFECTION ON LOCAL TUMOR-GROWTH AND METASTASIS IN AN H-2-NEGATIVE CLONE DERIVED FROM A CHEMICALLY-INDUCED FIBROSARCOMA
MIALDEA MJ; MARTIN J; GAFORIO JJ; ALGARRA I; PEREZ M; GONZALEZ A; LJUNGGREN HG; GARRIDO F
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1992;175(3):843-846
RESTORATION OF A TUMORIGENIC PHENOTYPE BY BETA-2-MICROGLOBULIN TRANSFECTION TO EL-4 MUTANT-CELLS
GLAS R; STURMHOFEL K; HAMMERLING GJ; KARRE K; LJUNGGREN HG
Journal article: CANCER JOURNAL. 1992;5(6):308-315
ROLE OF BETA-2-MICROGLOBULIN IN CANCER
LJUNGGREN HG
Journal article: INTERNATIONAL JOURNAL OF CANCER. 1991;49(6):906-910
DIFFERENTIAL MESSENGER-RNA LEVELS OF C-MYC, C-FOS AND MHC CLASS-I IN SEVERAL CLONES OF A MURINE FIBROSARCOMA
GAFORIO JJ; PEREZ M; ALGARRA I; MIALDEA MJ; LJUNGGREN HG; GARRIDO F
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(22):10332-10336
RECOGNITION OF BETA-2-MICROGLOBULIN-NEGATIVE (BETA-2M-) T-CELL BLASTS BY NATURAL-KILLER-CELLS FROM NORMAL BUT NOT FROM BETA-2M- MICE - NONRESPONSIVENESS CONTROLLED BY BETA-2M- BONE-MARROW IN CHIMERIC MICE
HOGLUND P; OHLEN C; CARBONE E; FRANKSSON L; LJUNGGREN HG; LATOUR A; KOLLER B; KARRE K
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1991;21(11):2767-2774
DIFFERENT TYPES OF ALLOSPECIFIC CTL CLONES IDENTIFIED BY THEIR ABILITY TO RECOGNIZE PEPTIDE LOADING-DEFECTIVE TARGET-CELLS
AOSAI F; OHLEN C; LJUNGGREN HG; HOGLUND P; FRANKSSON L; PLOEGH H; TOWNSEND A; KARRE K; STAUSS HJ
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1991;174(2):327-334
ALTERATION OF THE NATURAL-KILLER REPERTOIRE IN H-2 TRANSGENIC MICE - SPECIFICITY OF RAPID LYMPHOMA CELL CLEARANCE DETERMINED BY THE H-2 PHENOTYPE OF THE TARGET
HOGLUND P; GLAS R; OHLEN C; LJUNGGREN HG; KARRE K
Journal article: INTERNATIONAL JOURNAL OF CANCER. SUPPLEMENT = JOURNAL INTERNATIONAL DU CANCER. SUPPLEMENT. 1991;6:38-44
THE RMA-S LYMPHOMA MUTANT - CONSEQUENCES OF A PEPTIDE LOADING DEFECT ON IMMUNOLOGICAL RECOGNITION AND GRAFT-REJECTION
LJUNGGREN HG; OHLEN C; HOGLUND P; FRANKSSON L; KARRE K
Journal article: NEUROLOGICAL SURGERY. 1990;18(11):1015-1022
[Experimental analysis of anti-tumor cytotoxic mechanism for hybrid resistance to mouse neuroblastoma].
Yamasaki T; Moritake K; Kikuchi H; Kärre K; Ljunggren HG; Klein G
Journal article: INTERNATIONAL JOURNAL OF CANCER. 1990;46(2):258-261
A WEAKLY TUMORIGENIC PHENOTYPE WITH HIGH MHC CLASS-I EXPRESSION IS ASSOCIATED WITH HIGH METASTATIC POTENTIAL AFTER SURGICAL REMOVAL OF THE PRIMARY MURINE FIBROSARCOMA
PEREZ M; ALGARRA I; LJUNGGREN HG; CABALLERO A; MIALDEA MJ; GAFORIO JJ; KLEIN G; KARRE K; GARRIDO F
Journal article: NATURE. 1990;346(6283):476-480
EMPTY MHC CLASS-I MOLECULES COME OUT IN THE COLD
LJUNGGREN HG; STAM NJ; OHLEN C; NEEFJES JJ; HOGLUND P; HEEMELS MT; BASTIN J; SCHUMACHER TNM; TOWNSEND A; KARRE K; PLOEGH HL
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1990;20(8):1873-1876
RESTORATION OF H-2B EXPRESSION AND PROCESSING OF ENDOGENOUS ANTIGENS IN THE MHC CLASS-I PATHWAY BY FUSION OF A LYMPHOMA MUTANT TO L-CELLS OF THE H-2K HAPLOTYPE
OHLEN C; BASTIN J; LJUNGGREN HG; IMREH S; KLEIN G; TOWNSEND ARM; KARRE K
Journal article: JOURNAL OF IMMUNOLOGY. 1990;145(1):52-58
RESISTANCE TO H-2-RESTRICTED BUT NOT TO ALLO-H2-SPECIFIC GRAFT AND CYTOTOXIC LYMPHOCYTE-T RESPONSES IN LYMPHOMA MUTANT
OHLEN C; BASTIN J; LJUNGGREN HG; FOSTER L; WOLPERT E; KLEIN G; TOWNSEND ARM; KARRE K
Journal article: TRENDS IN IMMUNOLOGY. 1990;11(7):237-244
IN SEARCH OF THE MISSING SELF - MHC MOLECULES AND NK CELL RECOGNITION
LJUNGGREN HG; KARRE K
Journal article: JOURNAL OF IMMUNOLOGY. 1990;145(1):380-386
TRANSFECTION OF BETA-2-MICROGLOBULIN RESTORES IFN-MEDIATED PROTECTION FROM NATURAL-KILLER-CELL LYSIS IN YAC-1 LYMPHOMA VARIANTS
LJUNGGREN HG; STURMHOFEL K; WOLPERT E; HAMMERLING GJ; KARRE K
Journal article: IMMUNOLOGIC RESEARCH. 1990;9(4):298-313
ROLE OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES IN TUMOR REJECTION - NEW INSIGHTS FROM STUDIES WITH SYNTHETIC PEPTIDES AND TRANSGENIC MICE
HOGLUND P; LJUNGGREN HG; KARRE K; JAY G
Journal article: NEUROLOGIA MEDICO-CHIRURGICA. 1990;30(11 Spec No):800-805
[Cytotoxic effector mechanism and genetic control of non-immunized hybrid resistance to mouse T cell lymphoma transplanted outside and inside the brain].
Yamasaki T; Kikuchi H; Ljunggren HG; Kärre K; Klein G
Journal article: NEUROLOGIA MEDICO-CHIRURGICA. 1990;30(11 Spec No):789-795
[Molecular analysis of relationship between oncogene (N-myc and c-src) expression and major histocompatibility complex antigen gene expression in mouse neuroblastoma lines].
Yamasaki T; Kikuchi H; Yamashita J; Ljunggren HG; Kärre K; Klein G
Journal article: IMMUNOGENETICS. 1990;32(6):440-450
HIGH-RESOLUTION ONE-DIMENSIONAL ISOELECTRIC-FOCUSING OF MOUSE MHC CLASS-I ANTIGENS - IDENTIFICATION OF NATURAL AND EXPERIMENTALLY INDUCED CLASS-I ANTIGENS
LJUNGGREN HG; OUDSHOORNSNOEK M; MASUCCI MG; PLOEGH HL
Journal article: INTERNATIONAL JOURNAL OF CANCER. 1989;44(4):675-680
NK SENSITIVITY AND LUNG CLEARANCE OF MHC-CLASS-I-DEFICIENT CELLS WITHIN A HETEROGENEOUS FIBRO-SARCOMA
ALGARRA I; OHLEN C; PEREZ M; LJUNGGREN HG; KLEIN G; GARRIDO F; KARRE K
Journal article: INTERNATIONAL JOURNAL OF CANCER. 1989;44(4):669-674
EFFECT OF IFN-GAMMA TREATMENT AND INVIVO PASSAGE OF MURINE TUMOR-CELL LINES ON THEIR SENSITIVITY TO LYMPHOKINE-ACTIVATED KILLER (LAK) CELL-LYSIS INVITRO - ASSOCIATION WITH H-2 EXPRESSION ON THE TARGET-CELLS
TSAI L; OHLEN C; LJUNGGREN HG; KARRE K; HANSSON M; KIESSLING R
Journal article: NATURE. 1989;340(6233):443-448
ASSOCIATION OF CLASS-I MAJOR HISTOCOMPATIBILITY HEAVY AND LIGHT-CHAINS INDUCED BY VIRAL PEPTIDES
TOWNSEND A; OHLEN C; BASTIN J; LJUNGGREN HG; FOSTER L; KARRE K
Journal article: NEUROLOGICAL SURGERY. 1989;17(8):717-723
[Experimental analysis of intracerebral natural resistance against H-2+ and H-2- lymphomas grafted into the brain].
Yamasaki T; Kikuchi H; Yamashita J; Ljunggren HG; Karre K; Klein G
Journal article: CELLULAR IMMUNOLOGY. 1989;120(2):387-395
ENHANCED H-2 EXPRESSION AND T-CELL-DEPENDENT REJECTION AFTER INTRACEREBRAL TRANSPLANTATION OF THE MURINE LYMPHOMA YAC-1
YAMASAKI T; LJUNGGREN HG; OHLEN C; KLEIN G; KARRE K
Journal article: JOURNAL OF IMMUNOLOGY. 1989;142(9):3336-3341
STUDIES OF SUBLINES SELECTED FOR LOSS OF HLA EXPRESSION FROM AN EBV-TRANSFORMED LYMPHOBLASTOID CELL-LINE - CHANGES IN SENSITIVITY TO CYTO-TOXIC T-CELLS ACTIVATED BY ALLOSTIMULATION AND NATURAL-KILLER CELLS ACTIVATED BY IFN OR IL-2
OHLEN C; BEJARANO MT; GRONBERG A; TORSTEINSDOTTIR S; FRANKSSON L; LJUNGGREN HG; KLEIN E; KLEIN G; KARRE K
Journal article: JOURNAL OF IMMUNOLOGY. 1989;142(8):2911-2917
MOLECULAR ANALYSIS OF H-2-DEFICIENT LYMPHOMA LINES - DISTINCT DEFECTS IN BIOSYNTHESIS AND ASSOCIATION OF MHC CLASS-I HEAVY-CHAINS AND BETA-2-MICROGLOBULIN OBSERVED IN CELLS WITH INCREASED SENSITIVITY TO NK CELL-LYSIS
LJUNGGREN HG; PAABO S; COCHET M; KLING G; KOURILSKY P; KARRE K
Journal article: NEUROLOGICAL SURGERY. 1989;17(3):229-237
[Molecular analysis of mouse major histocompatibility complex class I gene expression of tumors growing in the brain].
Yamasaki T; Kikuchi H; Yamashita J; Kärre K; Ljunggren HG; Klein G
Journal article: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 1989;54:299-308
A MUTANT-CELL IN WHICH ASSOCIATION OF CLASS-I HEAVY AND LIGHT-CHAINS IS INDUCED BY VIRAL PEPTIDES
TOWNSEND A; OHLEN C; FOSTER L; BASTIN J; LJUNGGREN HG; KARRE K
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1988;168(4):1469-1474
NATURAL-RESISTANCE AGAINST LYMPHOMA GRAFTS CONVEYED BY H-2DD TRANSGENE TO C57BL MICE
HOGLUND P; LJUNGGREN HG; OHLEN C; AHRLUND-RICHTER L; SCANGOS G; BIEBERICH C; JAY G; KLEIN G; KARRE K
Journal article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 1988;80(4):263-269
EFFECTS OF DIMETHYL-SULFOXIDE TREATMENT ON H-2 EXPRESSION AND SUSCEPTIBILITY TO NK-MEDIATED OR CYTO-TOXIC LYMPHOCYTE-T-MEDIATED LYSIS OF THE YAC-1 LYMPHOMA AND ITS BETA-2-MICROGLOBULIN-DEFICIENT VARIANT
YAMASAKI T; KLEIN G; LJUNGGREN HG; HOGLUND P; OHLEN C; PETERSSON MGE; KARRE K
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1988;167(2):730-735
SELECTIVE ACCEPTANCE OF MHC CLASS-I DEFICIENT TUMOR GRAFTS IN THE BRAIN
LJUNGGREN HG; YAMASAKI T; COLLINS P; KLEIN G; KARRE K
Journal article: JOURNAL OF IMMUNOLOGY. 1988;140(2):671-678
AFFERENT AND EFFERENT CELLULAR INTERACTIONS IN NATURAL-RESISTANCE DIRECTED AGAINST MHC CLASS-I DEFICIENT TUMOR GRAFTS
LJUNGGREN HG; OHLEN C; HOGLUND P; YAMASAKI T; KLEIN G; KARRE K
Journal article: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. 1988;10:67
Effects of dimethyl sulfoxide (DMSO) treatment on H-2 expression and susceptibility to NK and CTL mediated lysis of YAC-1 lymphoma and its β2microglobulin (β2M) deficient variant
Yamasaki T; Kikuchi H; Yamashita J; Ljunggren HG; Kärre K; Klein G
Journal article: JOURNAL OF IMMUNOGENETICS. 1986;13(2-3):141-151
EXPERIMENTAL STRATEGIES AND INTERPRETATIONS IN THE ANALYSIS OF CHANGES IN MHC GENE-EXPRESSION DURING TUMOR PROGRESSION - OPPOSING INFLUENCES OF T-CELL AND NATURAL-KILLER MEDIATED RESISTANCE
LJUNGGREN HG; KARRE K
Journal article: NATURE. 1986;319(6055):675-678
SELECTIVE REJECTION OF H-2-DEFICIENT LYMPHOMA VARIANTS SUGGESTS ALTERNATIVE IMMUNE DEFENSE STRATEGY
KARRE K; LJUNGGREN HG; PIONTEK G; KIESSLING R
Journal article: JOURNAL OF IMMUNOLOGY. 1985;135(6):4281-4288
YAC-1 MHC CLASS-I VARIANTS REVEAL AN ASSOCIATION BETWEEN DECREASED NK SENSITIVITY AND INCREASED H-2 EXPRESSION AFTER INTERFERON TREATMENT OR INVIVO PASSAGE
PIONTEK GE; TANIGUCHI K; LJUNGGREN HG; GRONBERG A; KIESSLING R; KLEIN G; KARRE K
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1985;162(6):1745-1759
HOST-RESISTANCE DIRECTED SELECTIVELY AGAINST H-2-DEFICIENT LYMPHOMA VARIANTS - ANALYSIS OF THE MECHANISM
LJUNGGREN HG; KARRE K
Journal article: BRITISH JOURNAL OF NUTRITION. 1961;15:21-34
Basal metabolism in women with obesity and anorexia nervosa.
LJUNGGREN H; IKKOS D; LUFT R
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Book chapter: NATURAL KILLER CELLS. 2025;p. 1-23
Natural Killer Cells in the Human Lung
Marquardt N; Ljunggren H-G; Michaëlsson J
Preprint: MEDRXIV. 2024
Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort
Wullimann D; Sandberg JT; Akber M; Löfling M; Gredmark-Russ S; Michaëlsson J; Buggert M; Blom K; Ljunggren H-G
Preprint: BIORXIV. 2024
Crystallographic and NMR studies of Streptococcus pneumonia LCP protein Psr_Spindicate the importance of dynamics in four long loops for ligand specificity
Sandalova T; Sala BM; Moche M; Ljunggren H-G; Alici E; Henriques-Normark B; Agback T; Lesovoy D; Agback P; Achour A
Preprint: BIORXIV. 2024
Human NK cell responses to the SARS-CoV-2 Spike269-277 peptide YLQPRTFLL
Bilev E; Schiele S; Foglietta B; Ljunggren H-G; Hammer Q
Letter: HAEMATOLOGICA. 2024;109(2):646-651
Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia
Ingelman-Sundberg HM; Blixt L; Wullimann D; Wu J; Gao Y; Healy K; Muschiol S; Bogdanovic G; Aberg M; Kjellander C; Grifoni A; Sette A; Aleman S; Chen P; Blennow O; Hansson L; Ljunggren H-G; Chen MS; Buggert M; Osterborg A
Review: EUROPEAN JOURNAL OF IMMUNOLOGY. 2023;53(11):e2350465
Viral escape from NK-cell-mediated immunosurveillance: A lesson for cancer immunotherapy?
Momayyezi P; Bilev E; Ljunggren H-G; Hammer Q
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2023;293(6):664-665
SARS-CoV-2 antibody titers at the time of hospital admission and risk for mortality
Ljunggren H-G
Meeting abstract: JOURNAL OF IMMUNOLOGY. 2023;210(1):59.47
Identity of virus-specific and cross-reactive T cell memory to mpox
Adamo S; Gao Y; Cai C; Muller TR; Niessl J; Akhirunnesa M; Ljunggren H-G; Sallberg M; Bergman P; Ekstrom A-M; Grifoni A; Sette A; Price DA; Buggert M
Preprint: RESEARCH SQUARE. 2023
Booster mRNA vaccination post-SARS-CoV-2 infection enhances functional qualities of T cell immunity
Buggert M; Cai C; Gao Y; Ballesteros OR; Hansson L; Österborg A; Sandberg J; Ljunggren H-G; Björkström N; Strålin K; Qin C; Grifoni A; Weiskopf D; Wherry E; Sette A; Aleman S
Preprint: RESEARCH SQUARE. 2023
Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV
Ray S; Narayanan A; Vesterbacka J; Blennow O; Chen P; Gao Y; Gabarrini G; Ljunggren H-G; Buggert M; Manoharan L; Chen M; Aleman S; Sönnerborg A; Nowak P
Preprint: RESEARCH SQUARE. 2023
Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia
Ingelman-Sundberg H; Blixt L; Wullimann D; Wu J; Gao Y; Healy K; Muschiol S; Bogdanovic G; Åberg M; Kjellander C; Grifoni A; Sette A; Aleman S; Chen P; Blennow O; Hansson L; Ljunggren H-G; Chen MS; Buggert M; Österborg A
Conference publication: CYTOTHERAPY. 2023;25(6):S13-S14
GENERATION OF UNIVERSAL CELLULAR GRAFTS UTILIZING SIGNALING-DEFICIENT MEMBRANE-BOUND CD45 ENGAGERS
Hussain A; Mohammad DK; Karvouni M; Hallstrand C; Gilljam M; Wagner AK; Ljunggren H; Alici E
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(6)
Nobel 2022: An extraordinary achievement relevant to immunity
Hoglund P; Ljunggren H-G; Jonsson R
Letter: BLOOD. 2022;140(22):2403-2407
Hybrid immunity in immunocompromised patients with CLL after SARS-CoV-2 infection followed by booster mRNA vaccination
Blixt L; Gao Y; Wullimann D; Ingelman-Sundberg HM; Muschiol S; Healy K; Bogdanovic G; Pin E; Nilsson P; Kjellander C; Grifoni A; Sette A; Chen MS; Ljunggren H-G; Buggert M; Hansson L; Osterborg A
Preprint: BIORXIV. 2022
Jagged1 overexpression on T cells induces thymic regulatory T cells leading to thymic involution
Kritikou JS; Sánchez-Pascual I; Muñoz-Miranda JP; Vashist N; Wagner AK; Zhang X-M; Assarsson E; Dominguez-Villar M; Yagita H; Garcia-Cozar F; Riese P; Harris RA; Ljunggren H-G; Chambers BJ
Conference publication: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2022;22:s46-s47
P-020: PD1-based chimeric-switch receptor expressing NK cells recover from immune checkpoint inhibition in cancer
Susek K; Schwietzer Y; Karvouni M; Gilljam M; Keszei M; Baloch AH; Lund J; Kashif M; Lundqvist A; Ljunggren H-G; Nahi H; Wagner A; Alici E
Preprint: MEDRXIV. 2022
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial
Sandberg JT; Löfling M; Varnaitė R; Emgård J; Al-Tawil N; Lindquist L; Gredmark-Russ S; Klingström J; Loré K; Blom K; Ljunggren H-G
Letter: HAEMATOLOGICA. 2022;107(4):1000-1003
T-cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients with chronic lymphocytic leukemia: results from a prospective open-label clinical trial
Blixt L; Wullimann D; Aleman S; Lundin J; Chen P; Gao Y; Cuapio A; Akber M; Lange J; Rivera-Ballesteros O; Buggert M; Ljunggren H-G; Hansson L; Osterborg A
Review: NATURE REVIEWS IMMUNOLOGY. 2022;22(2):112-123
Natural killer cells in antiviral immunity
Bjorkstrom NK; Strunz B; Ljunggren H-G
Preprint: RESEARCH SQUARE. 2022
Ancestral SARS-CoV-2-specific T cells cross-recognize Omicron (B.1.1.529)
Gao Y; Cai C; Grifoni A; Müller T; Niessl J; Olofsson A; Humbert M; Hansson L; Österborg A; Bergman P; Chen P; Olsson A; Sandberg J; Weiskopf D; Price D; Ljunggren H-G; Karlsson A; Sette A; Aleman S; Buggert M
Conference publication: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2022;22:S46-S47
PD1-based chimeric-switch receptor expressing NK cells recover from immune checkpoint inhibition in cancer
Susek K; Schwietzer Y; Karvouni M; Gilljam M; Keszei M; Baloch AH; Lund J; Kashif M; Lundqvist A; Ljunggren H-G; Nahi H; Wagner A; Alici E
Meeting abstract: BLOOD. 2021;138:4796
CD38 Down-Regulation on Ex Vivo Activated and Expanded NK Cells for Cell Therapy Persists after Infusion
Nahi H; Chrobook M; Meinke S; Gran C; Marquardt N; Afram G; Sutlu T; Gilljam M; Stellan B; Wagner AK; Walther-Jallow L; Liwing J; Klimkowska M; Gahrton G; Ljungman P; Ljunggren H-G; Alici E
Preprint: MEDRXIV. 2021
Appearance of IgG to SARS-CoV-2 in saliva effectively indicates seroconversion in mRNA vaccinated immunocompromised individuals
Healy K; Pin E; Chen P; Söderdahl G; Nowak P; Mielke S; Hansson L; Bergman P; Smith E; Ljungman P; Valentini D; Blennow O; Österborg A; Gabarrini G; Al-Manei K; Alkharaan H; Sobkowiak MJ; Xu X; Akber M; Loré K; Hellström C; Muschiol S; Bogdanovic G; Buggert M; Ljunggren H-G; Hober S; Nilsson P; Aleman S; Sällberg Chen M
Preprint: MEDRXIV. 2021
Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial
Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Chen P; Söderdahl G; Österborg A; Edvard Smith CI; Wullimann D; Vesterbacka J; Lindgren G; Blixt L; Friman G; Wahren-Borgström E; Nordlander A; Gomez AC; Akber M; Valentini D; Norlin A-C; Thalme A; Bogdanovic G; Muschiol S; Nilsson P; Hober S; Loré K; Chen MS; Buggert M; Ljunggren H-G; Ljungman P; Aleman S; the COVAXID-collaborator group (shown separately)
Editorial comment: NEUROSCIENCE BULLETIN. 2021;37(7):1072-1074
Activated Natural Killer Cells Hit Neurogenesis in the Aging Brain
Cuapio A; Ljunggren H-G
Other: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;94(1)
Jacob B. Natvig (1934-2021), one of the founders of Scandinavian Journal of Immunology OBITURY
Jonsson R; Ljunggren H-G; Wigzell H; Froland SS; Meri S; Dembic Z; Orn A
Preprint: BIORXIV. 2021
Longitudinal characterization of humoral and cellular immunity in hospitalized COVID-19 patients reveal immune persistence up to 9 months after infection
Sandberg JT; Varnaitė R; Christ W; Chen P; Muvva J; Maleki K; García M; Dzidic M; Folkesson E; Skagerberg M; Ahlén G; Frelin L; Sällberg M; The Karolinska COVID-19 Study Group; Eriksson L; Rooyackers O; Sönnerborg A; Buggert M; Björkström N; Aleman S; Strålin K; Klingström J; Ljunggren H-G; Blom K; Gredmark-Russ S
Preprint: MEDRXIV. 2021
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LP; Kvedaraite E; Chen P; Muvva J; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki K; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg J; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson L; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström N; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers B; the Karolinska KI/K COVID-19 Study Group
Preprint: BIORXIV. 2021
Distinct lung-homing receptor expression and activation profiles on NK cell and T cell subsets in COVID-19 and influenza
Brownlie D; Rødahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaëlsson J; Gredmark-Russ S; Smed-Sörensen A; Marquardt N
Preprint: SSRN. 2021
Appearance of IgG to SARS-CoV-2 in Saliva Effectively Indicates Seroconversion in mRNA Vaccinated Immunocompromised Individuals
Healy K; Pin E; Chen P; Soderdahl G; Nowak P; Mielke S; Hansson L; Bergman P; Smith E; Ljungman P; Valentini D; Blennow O; Österborg A; Gabarrini G; Al-Manei K; Alkharaan H; Sobkowiak MJ; Xu X; Akber M; Lore K; Hellstrom C; Muschiol S; Bogdanovic G; Buggert M; Ljunggren H-G; Hober S; Nilsson P; Aleman S; Chen MS
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;93(1):e12993
Paths taken towards NK cell-mediated immunotherapy of human cancer-a personal reflection
Ljunggren H-G
Preprint: MEDRXIV. 2020
Innate lymphoid cell composition associates with COVID-19 disease severity
García M; Kokkinou E; García AC; Parrot T; Palma Medina L; Maleki K; Christ W; Varnaitė R; Filipovic I; Ljunggren H-G; Björkström N; Folkesson E; Rooyackers O; Eriksson L; Sönnerborg A; Aleman S; Strålin K; Gredmark-Russ S; Klingström J; Mjösberg J; the Karolinska KI/K COVID-19 Study Group
Preprint: MEDRXIV. 2020
MAIT cell activation and dynamics associated with COVID-19 disease severity and outcome
Parrot T; Gorin J-B; Ponzetta A; Maleki K; Kammann T; Emgârd J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; the Karolinska COVID-19 Study Group; Folkesson E; Rooyackers O; Eriksson L; Norrby-Teglund A; Ljunggren H-G; Björkström N; Aleman S; Buggert M; Klingström J; Strålin K; Sandberg J
Preprint: MEDRXIV. 2020
Perturbations in the mononuclear phagocyte landscape associated with COVID-19 disease severity
Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingström J; Folkesson E; Muvva JR; Chen P; Brighenti S; Norrby-Teglund A; Eriksson L; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Ginhoux F; Björkström N; Henter J-I; Svensson M; Karolinska COVID-19 Study Group
Preprint: MEDRXIV. 2020
Natural killer cell activation related to clinical outcome of COVID-19
Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Gomez AC; Ask EH; Hull R; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg J; Eriksson L; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström N; Karolinska COVID-19 Study Group
Preprint: BIORXIV. 2020
Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
Sekine T; Perez-Potti A; Rivera-Ballesteros O; Strålin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann D; Kammann T; Emgård J; Parrot T; Folkesson E; Rooyackers O; Eriksson L; Sönnerborg A; Allander T; Albert J; Nielsen M; Klingström J; Gredmark-Russ S; Björkström N; Sandberg J; Price D; Ljunggren H-G; Aleman S; Buggert M; Karolinska COVID-19 Study Group
Preprint: BIORXIV. 2020
Expansion of SARS-CoV-2-specific Antibody-secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients
Varnaitė R; García M; Glans H; Maleki K; Sandberg JT; Tynell J; Christ W; Lagerqvist N; Asgeirsson H; Ljunggren H-G; Ahlén G; Frelin L; Sällberg M; Blom K; Klingström J; Gredmark-Russ S
Book chapter: THE AUTOIMMUNE DISEASES. 2020;p. 229-242
Chapter 12 Natural Killer Cells
Bryceson YT; Björkström NK; Mjösberg J; Ljunggren H-G
Preprint: BIORXIV. 2019
Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood
Marquardt N; Scharenberg M; Mold JE; Hård J; Kekäläinen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Michaëlsson J
Conference publication: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2019;19(10):E169
Combination of herpes-simplex based oncolytic viruses (HSV-OV) with natural killer (NK) cells in Multiple Myeloma
Susek KH; Meinke S; Wagner AK; Ljunggren H-G; Alici E
Meeting abstract: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2019;19(10):E170
Novel RNA construct increases cytotoxic proteins in lymphocytes and leads to prolonged survival in an experimental syngeneic immunocompetent Multiple Myeloma model
Wagner AK; Baloch AH; Chrobok M; Dahlberg C; Gahrton G; Nahi H; Ljunggren H-G; Alici E
Meeting abstract: BLOOD. 2018;132:195
Efficient Scale-up and Pre-Clinical Evaluation of NKG2C+Adaptive NK Cell Expansion for Therapy Against High-Risk AML/MDS
Sohlberg E; Haroun-Izquierdo A; Bjorklund AT; Cooley S; Wiiger MT; Goodridge P; Hoel HJ; Pfefferle A; Chrobook M; Kremer V; Hellstrom-Lindberg E; Ask EH; Pontus B; Valamehr B; Guldevall K; van Ooijen H; Onfelt B; Alici E; Ljunggren H-G; Miller JS; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174
Cell-Mediated Immune Responses and Immunopathogenesis of Human Tick-Borne Encephalitis Virus-Infection
Blom K; Cuapio A; Sandberg JT; Varnaite R; Michaelsson J; Bjorkstrom NK; Sandberg JK; Klingstrom J; Lindquist L; Russ SG; Ljunggren H-G
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2017;282(3):206-208
Prospects for induction of CD8 T cell-mediated immunity to Zika virus infection by yellow fever virus vaccination
Blom K; Sandberg JT; Lore K; Ljunggren H-G
Review: IMMUNOGENETICS. 2017;69(8-9):547-556
Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition
Malmberg K-J; Sohlberg E; Goodridge JP; Ljunggren H-G
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(1):318
Polyfunctionality of bona fide resident lung CD69⁺ natural killer cells Reply
Marquardt N; Ljunggren H-G; Michaelsson J
Review: SEMINARS IN IMMUNOLOGY. 2017;31:20-29
Natural killer cell-mediated immunosurveillance of human cancer
Malmberg K-J; Carlsten M; Bjorklund A; Sohlberg E; Bryceson YT; Ljunggren H-G
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):291
Inverse expression of the inhibitory/activating receptors TIGIT/CD226 on CD8 T cells in acute HFRS
Tauriainen J; Maleki K; Blom K; Bjorkstrom N; Ahlm C; Ljunggren H-G; Klingstrom J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):318
Modifications of TIGIT expression contribute to CD8 T cell exhaustion in chronic virus infection
Tauriainen J; Scharf L; Frederiksen J; Naji A; Ljunggren H-G; Sonnerborg A; Lund O; Reyes-Teran G; Hecht FM; Deeks SG; Betts MR; Buggert M; Karlsson AC
Conference publication: JOURNAL OF IMMUNOLOGY. 2017;198(1)
HIV-induced modifications of TIGIT expression impair CD8 T cell polyfunctionality
Scharf L; Tauriainen J; Frederiksen J; Naji A; Ljunggren H-G; Sonnerborg A; Lund O; Reyes-Teran G; Hecht FM; Deeks SG; Betts MR; Buggert M; Karlsson AC
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):348
Optimized genetic modification of primary human NK cells
Wagner AK; Chrobok M; Hussain A; Gilljam M; Dahlberg CIM; Sutlu T; Duru AD; Nahi H; Lundqvist A; Ljunggren H-G; Alici E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):250
Human plasmablast and B cell responses to vaccination with different flavivirus vaccines
Sandberg J-T; Lore K; Blom K; Ljunggren H-G
Review: NATURE REVIEWS IMMUNOLOGY. 2016;16(5):310-320
Emerging insights into natural killer cells in human peripheral tissues
Bjorkstrom NK; Ljunggren H-G; Michaelsson J
Conference publication: BONE MARROW TRANSPLANTATION. 2016;51:S97-S98
ADOPTIVELY TRANSFERRED HAPLOIDENTICAL NK CELLS AGAINST REFRACTORY MDS, HIGH-RISK MDS AND REFRACTORY AML AS A BRIDGE TO TRANSPLANTATION. COMPLETE REMISSION ASSOCIATED WITH DETECTABLE NK CELLS
Bjorklund AT; Carlsten M; Sohlberg E; Liu L; Schaffer M; Watz E; Ljungman P; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2016;395:63-94
Diversification and Functional Specialization of Human NK Cell Subsets
Cichocki F; Schlums H; Theorell J; Tesi B; Miller JS; Ljunggren H-G; Bryceson YT
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:67-68
Human lung NK cells are predominantly constituted by highly differentiated hypofunctional CD69^-CD56^dim cells
Marquardt N; Kekalainen E; Wilson JN; Ivarsson MA; Mjosberg J; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
Editorial comment: EMBO REPORTS. 2015;16(10):1246-1249
Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances
Ljunggren H-G; Chien KR
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;82(3):161-162
Dear Readers of Scandinavian Journal of Immunology and ECI2015 Attendees
Jonsson R; Ljunggren H-G
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2015;45(7):2154-2157
High-resolution determination of human immune cell signatures from fine-needle liver aspirates
Hengst J; Theorell J; Deterding K; Potthoff A; Dettmer A; Ljunggren H-G; Wedemeyer H; Bjorkstrom NK
Conference publication: JOURNAL OF VIRAL HEPATITIS. 2015;22:68
High-resolution determination of human hepatic immune cell signatures from fine-needle liver aspirates
Hengst J; Theorell J; Deterding K; Potthoff A; Dettmer A; Ljunggren H-G; Wedemeyer H; Bjorkstrom NK
Meeting abstract: LEUKEMIA RESEARCH. 2015;39:S25-S26
ADOPTIVELY TRANSFERRED HAPLOIDENTICAL NK CELLS AGAINST REFRACTORY MDS, HIGH-RISK MDS AND REFRACTORY AML AS A BRIDGE TO TRANSPLANTATION. COMPLETE REMISSION ASSOCIATED WITH DETECTABLE NK CELLS
Bjorklund AT; Carlsten M; Liu L; Schaffer M; Watz E; Palma M; Hansson L; Mollgard L; Cooley SA; Miller JS; Ljungman PT; Hellstrom-Lindberg E; Ljunggren HG; Malmberg KJ
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(1):1
Scandinavian Journal of Immunology embraces 21st century publishing: moving to online-only publication
Jonsson R; Ljunggren H-G
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196
Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
Beziat V; Traherne J; Malmberg J-A; Ivarsson MA; Bjorkstrom NK; Retiere C; Ljunggren H-G; Michaelsson J; Trowsdale J; Malmberg K-J
Editorial comment: SCIENCE TRANSLATIONAL MEDICINE. 2014;6(217):217ed1
Academia and Big Pharma United
Ljunggren H-G
Book chapter: THE AUTOIMMUNE DISEASES. 2014;p. 187-199
Chapter 13 Natural Killer Cells
Bryceson YT; Björkström NK; Mjösberg J; Ljunggren H-G
Conference publication: BONE MARROW TRANSPLANTATION. 2014;49:S134-S135
INTERIM REPORT OF A CLINICAL STUDY WITH HAPLOIDENTICAL NK-CELLS AGAINST HIGH RISK MDS AND AML
Bjorklund AT; Carlsten M; Liu L; Er MS; Cooley S; Miller JS; Watz E; Wahlin B; Palma M; Hansson L; Ljungman P; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J
Conference publication: HLA. 2014;84(1):35
INTERIM REPORT OF A CLINICAL STUDY WITH HAPLOIDENTICAL NK-CELLS AGAINST HIGH RISK MDS AND AML
Bjorklund AT; Carlsten M; Liu L; Schaffer M; Watz E; Cooley S; Miller JS; Hellstrom-Lindberg E; Ljungman PT; Ljunggren H-G; Malmberg K-J
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;78(2):111
The ICI2013 Scandinavian Journal of Immunology issue
Jonsson R; Ljunggren H-G
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:182.1
Hantaviruses employ multiple mechanisms to evade NK cell recognition
Braun M; Klingstrom J; Gupta S; Bjorkstrom N; Ljunggren H-G
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:49.17
Dynamics of natural killer cell responses to hepatitis delta virus infection during the course of interferon alpha treatment
Lunemann S; Malone D; Manns M; Sandberg J; Cornberg M; Ljunggren H-G; Wedemeyer H; Bjorkstrom N
Conference publication: JOURNAL OF HEPATOLOGY. 2013;58:S144
COMPRISED FUNCTION OF NATURAL KILLER CELLS IN ACUTE AND CHRONIC VIRAL HEPATITIS
Lunemann S; Malone DFG; Schlaphoff V; Manns MP; Sandberg JK; Cornberg M; Ljunggren H-G; Bjorkstrom NK; Wedemeyer H
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2013;24
Organelle trafficking and recruitment of effector proteins to natural killer cell lytic granules in response to distinct activating signals
Wood S; Chiang S; Meeths M; Henter J-I; Ljunggren H-G; Bryceson Y
Conference publication: HEPATOLOGY. 2013;58:417A
Dynamics of the Natural Killer Cell Response to Hepatitis Delta Virus-Infection and Interferon-α Treatment
Lunemann S; Malone DF; Grabowski J; Port K; Beziat V; Bremer B; Malmberg K-J; Manns MP; Sandberg JK; Cornberg M; Ljunggren H-G; Wedemeyer H; Bjorkstrom NK
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(12):3141-3145
Spotlight on NKG2C and the human NK-cell response to CMV infection
Malmberg K-J; Beziat V; Ljunggren H-G
Editorial comment: CARDIOVASCULAR RESEARCH. 2012;96(2):176-180
Proatherogenic role of interleukin-18: effects on inflammation and action on vascular cells
Elhage R; Ljunggren H-G; Hansson GK
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(3):211-212
Dear readers of Scandinavian Journal of Immunology and ECI2012 attendees
Jonsson R; Ljunggren H-G
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2012;271(2):174-176
Dendritic cells, dendritic cell-based vaccines and Ralph Steinman
Ljunggren H-G
Conference publication: IMMUNOLOGY. 2012;137:638
Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis
Gupta S; Braun M; Tischler ND; Stoltz M; Sundstrom KB; Bjorkstrom NK; Ljunggren HG; Klingtsrom J
Conference publication: IMMUNOLOGY. 2012;137:128-129
Mapping the diversity of human KIR repertoires and their adaptation to infection
Beziat V; Liu L; Sohlberg E; Retiere C; Traherne JA; Sverremark-Ekstrom E; Trowsdale J; Michaelsson J; Ljunggren HG; Malmberg KJ
Conference publication: ALLERGY. 2012;67:637
Human natural killer cells in the lung, and their role in the development of asthma
Kekalainen E; Bjorkstrom N; Dahlen S; Ljunggren H
Other: IMMUNITY. 2011;35(5):653-657
Killer Cell Immunoglobulin-like Receptor Workshop: Insights into Evolution, Genetics, Function, and Translation
Malmberg K-J; Michaelsson J; Parham P; Ljunggren H-G
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2011;68(21):3479-3493
Insights into NK cell biology from human genetics and disease associations
Wood SM; Ljunggren H-G; Bryceson YT
Review: NATURE REVIEWS IMMUNOLOGY. 2011;11(10):658-671
Organ-specific features of natural killer cells
Shi F-D; Ljunggren H-G; La Cava A; Van Kaer L
Editorial comment: JOURNAL OF INNATE IMMUNITY. 2011;3(3):213-215
Natural Killer Cells: Biology, Physiology and Medicine - Part 1
Bryceson YT; Ljunggren H-G
Editorial comment: JOURNAL OF INNATE IMMUNITY. 2011;3(4):327-328
Natural Killer Cells: Biology, Physiology and Medicine - Part 2
Bryceson YT; Ljunggren H-G
Review: TRENDS IN IMMUNOLOGY. 2010;31(11):401-406
CD56 negative NK cells: origin, function, and role in chronic viral disease
Bjorkstrom NK; Ljunggren H-G; Sandberg JK
Editorial comment: IMMUNOLOGY AND CELL BIOLOGY. 2010;88(2):105-106
Unique features of NK cell development during ontogeny revealed in studies of RAG-1-deficient mice
Chambers BJ; Ljunggren H-G
Book chapter: NATURAL KILLER CELLS. 2010;p. 405-421
Natural Killer Cells in the Treatment of Human Cancer
Malmberg K-J; Ljunggren H-G
Book chapter: NATURAL KILLER CELLS. 2010;p. 55-64
Chapter Four Natural killer cells in cancer
Höglund P; Ljunggren H-G
Conference publication: HEPATOLOGY. 2010;52(4):740A-741A
IFNα ACTIVATED NK CELLS REQUIRE DNAM-1 FOR RECOGNITION OF INFECTED CELLS DURING ACUTE HCV INFECTION
Stegmann KA; Bjorkstrom NK; Ciesek S; Jaroszewicz J; Wiegand J; Malinski P; Manns MP; Pietschmann T; Ljunggren H-G; Wedemeye H
Other: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2009;70(6):503-504
Professor emeritus Jacob B. Natvig, one of the founders of Scandinavian Journal of immunology, turns 75
Capra JD; Froland SS; Harboe M; Jonsson R; Ljunggren H-G; Wigzell H
Review: CURRENT OPINION IN IMMUNOLOGY. 2009;21(6):634-640
Natural killer cells in human autoimmunity
Flodstrom-Tullberg M; Bryceson YT; Shi F-D; Hoglund P; Ljunggren H-G
Meeting abstract: HUMAN IMMUNOLOGY. 2009;70:S100
MAINTAINED TOLERANCE OF NK CELLS EXPRESSING INHIBITORY KIR FOR NON-SELF LIGANDS IN HLA-MATCHED SIBLING STEM CELL TRANSPLANTATION
Schaffer M; Bjorklund A; Fauriat C; Ringden O; Remberger M; Ljungman P; Ljunggren H-G; Malmberg K-J
Corrigendum: INFECTION AND IMMUNITY. 2009;77(8):3516
Transmission of Toxoplasma gondii from Infected Dendritic Cells to Natural Killer Cells (vol 77, pg 972, 2009)
Persson CM; Lambert H; Vutova PP; Dellacasa-Lindberg I; Nederby J; Yagita H; Ljunggren H-G; Grandien A; Barragan A; Chambers BJ
Review: INTERNATIONAL JOURNAL OF CANCER. 2009;124(4):757-762
Natural killer cell-mediated lysis of freshly isolated human tumor cells
Carlsten M; Malmberg K-J; Ljunggren H-G
Editorial comment: NATURE IMMUNOLOGY. 2009;10(1):11-12
Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Malmberg K-J; Ljunggren H-G
Conference publication: HLA. 2009;73(5):397
Maintained hyporesponsiveness of NK cells expressing inhibitory KIR for non-self ligands in HLA-matched sibling stem cell transplantation
Schaffer M; Bjorklund A; Fauriat C; Ringden O; Remberger M; Ljungman P; Ljunggren H-G; Malmberg K-J
Conference publication: BONE MARROW TRANSPLANTATION. 2009;43:S303
Maintained hyporesponsiveness of NK cells expressing inhibitory KIR for non-self ligands in HLA-matched sibling stem cell transplantation
Bjorklund AT; Schaffer M; Fauriat C; Ringden O; Remberger M; Ljungman P; Ljunggren HG; Malmberg KJ
Conference publication: HEPATOLOGY. 2009;50(4):933A
IFN-ALPHA STIMULATED NK CELLS ARE CAPABLE OF KILLING HCV-INFECTED HEPATOMA CELLS VIA TRAIL
Stegmann KA; Ciesek S; Bjorkstrom NK; Cornberg M; Manns MP; Pietschmann T; Ljunggren H-G; Wedemeyer H
Conference publication: BONE MARROW TRANSPLANTATION. 2009;43:S302-S303
Increasing probabilities of kir expression characterize the formation of inhibitory kir repertoires: evidence against selection of human NK cells
Andersson S; Fauriat C; Malmberg JA; Ljunggren HG; Malmberg KJ
Published conference paper: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2008;57(10):1541-1552
NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Malmberg K-J; Bryceson YT; Carlsten M; Andersson S; Bjorklund A; Bjorkstrom NK; Baumann BC; Fauriat C; Alici E; Dilber MS; Ljunggren H-G
Editorial comment: NATURE IMMUNOLOGY. 2008;9(8):835-836
Arrestin NK cell cytotoxicity
Bryceson YT; Ljunggren H-G
Editorial comment: IMMUNITY. 2008;28(4):492-494
Cancer immunosurveillance: NKG2D breaks cover
Ljunggren H-G
Review: JOURNAL OF IMMUNOLOGY. 2008;180(1):19-24
Immune modulation by the human cytomegalovirus-encoded molecule UL18, a mystery yet to be solved
Wagner CS; Ljunggren H-G; Achour A
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):238-239
Elevated numbers of FcγRIIIA+ (CD16⁺) effector CD8 T-cells with NK cell-like function in chronic HCV infection
Bjorkstrom N; Gonzalez V; Malmberg K-J; Falconer K; Alaeus A; Nowak G; Jorns C; Ericzon B-G; Weiland O; Sandberg J; Ljunggren H-G
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):224
Influence of cognate Ligands on the functional maturation of KIR3DL2 Positive NK cells
Bjorklund A; Fauriat C; Andersson S; Schaffer M; Bjorkstrom N; Ljunggren H-G; Malmberg K
Meeting abstract: JOURNAL OF HEPATOLOGY. 2008;48:S233
Comprehensive phenotypic analysis of NK cells in acute hepatitis C virus infection
Stegmann KA; Bjorkstrom NK; Wiegand J; Ljunggren HG; Manns MP; Wedemeyer H
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):219
Role of Rab27a and Munc13-4 in NK cell granule exocytosis and disease
Wood S; Meeths M; Henter J-I; Stow J; Ljunggren H-G; Bryceson Y
Conference publication: HUMAN GENE THERAPY. 2008;19(10):1183
Ex vivo expanded autologous natural killer cells as a novel therapeutic approach in multiple myeloma
Alici E; Sutlu T; Bjokstrand B; Gilljam M; Stellan B; Nahi H; Quezada HC; Gahrton G; Ljunggren H-G; Dilber MS
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):186
Sustained NK cell receptor imprinting caused by acute Puumala Hantavirus infection in humans
Bjorkstrom N; Klingstrom J; Fauriat C; Stoltz M; Michaelsson J; Malmberg K-J; Ahlm C; Ljunggren H-G
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):245
NKG2D mediates TCR-independent degranulation and antiviral cytolytic activity in CD4-CD1d restricted NKT cells
Kuylenstierna C; Bjorkstrom NK; Malmberg K-J; Ljunggren H-G; Moll M; Sandberg JK
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):250
Evidence for end-stage maturational fine-tuning within the human NK cell receptor repertoire
Riese P; Bjorkstrom NK; Fauriat C; Andersson S; Guzman CA; Ljunggren H-G; Malmberg K-J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):246
Comprehensive phenotypic analysis of NK cells in patients with acute hepatitis C virus infection
Stegmann KA; Bjorkstrom NK; Wiegand J; Ljunggren H-G; Manns MP; Wedemeyer H
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):223
The size of the alloreactive NK cell subset:: Implications for donor selection in allogeneic stem cell transplantation
Andersson S; Fauriat C; Bjorklund A; Carlsten M; Schaffer M; Bjorkstrom NK; Baumann BC; Ljunggren H-G; Malmberg K-J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):185
Altered receptor repertoire and impaired function of tumor associated natural killer cells in ovarian carcinoma
Carlsten M; Norell H; Bryceson Y; Schedvins K; Ljunggren H-G; Kiessling R; Malmberg K-J
Other: JOURNAL OF IMMUNOLOGY. 2007;179(7):4301-4306
Association of class I major histocompatibility heavy and light chains induced by viral peptides (Reprinted from Nature, vol 340, pg 443-448, 1989)
Townsend A; Ohlen C; Bastin J; Ljunggren H-G; Foster L; Karre K
Editorial comment: CURRENT OPINION IN IMMUNOLOGY. 2007;19(3):337-338
Lymphocyte effector functions: armed for destruction?
Bryceson YT; Ljunggren H-G
Review: NATURE REVIEWS IMMUNOLOGY. 2007;7(5):329-339
Prospects for the use of NK cells in immunotherapy of human cancer
Ljunggren H-G; Malmberg K-J
Conference publication: INFLAMMATION RESEARCH. 2007;56:S382
NK cells and their role in allergic inflammation
Ljunggren H-G
Conference publication: ACTA DIABETOLOGICA. 2007;44:S23
Alpha production dominates the early human natural killer cell response to coxsackievirus infection
Huhn MH; Hultcrantz M; Lind K; Ljunggren H-G; Malmberg K-J; Flodstrom-Tullberg M
Review: IMMUNOLOGICAL REVIEWS. 2006;214:73-91
Activation, coactivation, and costimulation of resting human natural killer cells
Bryceson YT; March ME; Ljunggren H-G; Long EO
Meeting abstract: HUMAN IMMUNOLOGY. 2006;67(10):S129
KIR-HLA mismatch in T-cell replete HLA-identical sibling hematopoietic stem cell transplantation for acute myelogenous leukemia
Schaffer M; Remberger M; Ringden O; Ljunggren H-G; Malmberg K-J
Review: SEMINARS IN CANCER BIOLOGY. 2006;16(1):16-31
Escape from immune- and nonimmune-mediated tumor surveillance
Malmberg KJ; Ljunggren HG
Conference publication: JOURNAL OF IMMUNOLOGY. 2006;176:S207-S208
Non-CD1d-restricted NKT cells recognize dendritic cells by TCR-independent but CD2 family member-regulated mechanisms
Joshi PS; Liu J-Q; Wang Y; Chang X; Richards J; Shi F-D; Assarsson E; Ljunggren H-G; Zheng P; Liu Y; Bai X-F
Review: JOURNAL OF IMMUNOLOGY. 2005;175(4):2045-2049
2B4/CD48-mediated regulation of lymphocyte activation and function
Assarsson E; Kambayashi T; Persson CM; Chambers BJ; Ljunggren HG
Other: JOURNAL OF IMMUNOLOGY. 2005;174(11):6566-6569
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy (Reprinted from Nature 319: 675-678 (1986))
Kärre K; Ljunggren HG; Piontek G; Kiessling R
Published conference paper: MOLECULAR IMMUNOLOGY. 2005;42(4):531-534
KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation
Malmberg KJ; Schaffer M; Ringdén O; Remberger M; Ljunggren HG
Published conference paper: MOLECULAR IMMUNOLOGY. 2005;42(4):495-499
Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells
Screpanti V; Wallin RPA; Grandien A; Ljunggren HG
Published conference paper: MOLECULAR IMMUNOLOGY. 2005;42(4):419-423
2B4 co-stimulation: NK cells and their control of adaptive immune responses
Assarsson E; Kambayashi T; Persson CM; Ljunggren HG; Chambers BJ
Conference publication: XENOTRANSPLANTATION. 2005;12(5):368
The molecular specificity of natural killer cells
Ljunggren HG
Conference publication: GENES AND IMMUNITY. 2005;6:S49
Infection related mortality in KIR-ligand mismatch in unrelated allogeneic hematopoetic stem cell transplantation
Schaffer M; Ringdén O; Remberger M; Ljunggren HG; Malmberg KJ
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2004;60:S174
Crystal structure of major cat allergen Fel d 1
Sandalova T; Kaiser L; Gronlund H; Ljunggren H-G; van Hage-Hamsten M; Achour A; Schneider G
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;60(1-2):14-22
Activation of natural killer cells:: Underlying molecular mechanisms revealed
Backström E; Kristensson K; Ljunggren HG
Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2004;5(1):42
CD1d-dependent activation of NKT cells aggravates atherosclerosis
Tupin E; Nicoletti A; Elhage R; Rudling M; Ljunggren H; Hansson G; Berne GP
Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2004;154(1-2):205
Regulation of natural killer cell stimulatory and inhibitory molecules in mouse nervous system
Backström E; Drenth AFJ; Sjölin H; Ljunggren HG; Kristensson K
Conference publication: ANTICANCER RESEARCH. 2004;24(5D):3672
CTL TARGETING OF TUMORS WITH DEFECTS IN MHC CLASS I ANTIGEN PROCESSING
Wolpert EZ; van Hall T; Grufman P; van der Veer M; Laban S; Fredriksson V; Camps M; Torstensson E; Ossendorp F; Ljunggren H-G; Kaerrel K; Melief CJM; Offringa R
Conference publication: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2004;197(3):279-280
The inflammatory response after inhalation of alkylating chemicals in mice is dependent on T lymphocytes and natural killer (NK) cells
Ekstrand-Hammarström B; Ljunggren HG; Bucht A
Conference publication: GENES AND IMMUNITY. 2004;5:S4
Inferior survival and increased infectious related mortality in KIR-ligand mismatched unrelated stem cell transplantation
Schaffer M; Malmberg KJ; Ringden O; Ljunggren HG; Remberger M
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(5):432-441
The natural killer cell -: Friend or foe in autoimmune disease?
Flodström M; Shi FD; Sarvetnick N; Ljunggren HG
Editorial comment: TRENDS IN IMMUNOLOGY. 2002;23(3):130-135
Heat-shock proteins as activators of the innate immune system
Wallin RPA; Lundqvist A; Moré SH; von Bonin A; Kiessling R; Ljunggren HG
Conference publication: BLOOD. 2002;100(11):595A
Derivation of expanded killer cells from patients with B-chronic lymphocytic leukemia (B-CLL): A potential source for cellular immunotherapy.
Guven H; Gilljam M; Chambers BJ; Ljunggren HG; Christensson B; Kimby E; Dilber MS
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S221
Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets contribute differently to the pathogenesis
Chen ZG; Zhu J; Yu S; Concha HQ; Zhu Y; Mix E; Winblad R; Ljunggren HG
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S25
Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice
Chen ZG; Zhu J; Ljunggren HG; Bogdanovic N; Nennesmo I; Winblad B
Letter: TRENDS IN IMMUNOLOGY. 2001;22(6):301
Autoimmunity mediated by innate immune effector cells -: Response from Shi et al.
Shi FD; Sarvetnick N; Ljunggren HG
Review: TRENDS IN IMMUNOLOGY. 2001;22(2):97-101
Innate immunity and autoimmunity: from self-protection to self-destruction
Shi FD; Ljunggren HG; Sarvetnick N
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(4):1014
Reduced susceptibility of human immature dendritic cells (iDC) to NK cell lysis after interaction with the opportunistic yeast Malassezia furfur (Mf)
Buentke E; Heffler LC; Wilson J; Wallin RPA; Löfman C; Chambers BJ; Ljunggren HG; Scheynius A
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(3):804
Reduced susceptibility of human immature dendritic cells (IDC) to NK cell lysis after interaction with the opportunistic yeast Malassezia furfur (MF)
Buentke E; Heffler LC; Wilson J; Wallin RPA; Chambers BJ; Ljunggren HG; Scheynius A
Book chapter: MYASTHENIA GRAVIS. 2000;p. 116-124
Experimental myasthenia gravis in mice: The role of costimulatory molecules
Shi FD; He B; Li HL; Matusevicius D; Link H; Ljunggren HG
Conference publication: JOURNAL OF LEUKOCYTE BIOLOGY. 2000;:33
Control B cell-mediated autoimmune response by type 2 nitric oxide synthase (NOS2)
Shi FD; Flodström M; Kim SH; Cleary MM; Ljunggren HG; Sarvetnick N
Review: IMMUNOLOGICAL REVIEWS. 1999;172:153-162
Processing of bacterial antigens for peptide presentation on MHC class I molecules
Wick MJ; Ljunggren HG
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 1998;230:53-61
Triggering of natural killer cell mediated cytotoxicity by costimulatory molecules
Chambers BJ; Wilson JL; Salcedo M; Markovic K; Bejarano MT; Ljunggren HG
Review: IMMUNOLOGICAL REVIEWS. 1997;155:11-28
Host MHC class I gene control of NK-cell specificity in the mouse
Hoglund P; Sundback J; OlssonAlheim MY; Johansson M; Salcedo M; Ohlen C; Ljunggren HG; Sentman CL; Karre K
Book chapter: MOLECULAR BASIS OF NK CELL RECOGNITION AND FUNCTION: CHEMICAL IMMUNOLOGY AND ALLERGY. 1996;p. 44-58
Natural Killer Cells in MHC Class I Deficient Mice
Salcedo M; Ljunggren H-G
Review: IMMUNOLOGICAL REVIEWS. 1996;151:123-148
Reactivity and specificity of CD8(+) T cells in mice with defects in the MHC class I antigen-presenting pathway
Ljunggren HG; Glas R; Sandberg JK; Karre K
Review: CANCER JOURNAL. 1996;9(6):304-307
MHC class I molecules, their role in presenting peptide antigens, including tumor antigens, to cytotoxic T lymphocytes
Freland S; Chambers BJ; Ljunggren HG
Conference publication: HUMAN IMMUNOLOGY. 1996;47(1-2):P599
Reactivity and specificity of CD8+ T cells in MHC class 1 deficient mice
Ljunggren HG; Chambers B; Freland S; Glas R; Sandberg J; Karre K
Review: CHEMICAL IMMUNOLOGY AND ALLERGY. 1996;64:44-58
Natural killer cells in MTC class I deficient mice
Salcedo M; Ljunggren HG
Review: HISTOLOGY AND HISTOPATHOLOGY. 1996;11(1):267-274
Principles of MHC class I-mediated antigen presentation and T cell selection
Ljunggren HG; Thorpe CJ
Conference publication: FASEB JOURNAL. 1994;8(5):A748
POSITIVE SELECTION OF SELF-REACTIVE AND ALLOREACTIVE CD8+ T-CELLS IN TAP-1 MUTANT MICE
ALDRICH CJ; LJUNGGREN HG; VANKAER L; ASHTONRICKARDT PG; TONEGAWA S; FORMAN J
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1993;:49
ANTIGEN PROCESSING MUTANT T2 CELLS PRESENT VIRAL-ANTIGEN RESTRICTED THROUGH H-2KB
ZHOU XZ; GLAS R; LJUNGGREN HG; JONDAL M
Book chapter: MODERN TRENDS IN HUMAN LEUKEMIA IX. 1992;p. 267-278
Natural Killer Cell Mediated Defence Directed Selectively Against Target Cells Lacking MHC Class I Gene Products
Ljunggren H-G; Höglund P; Öhlén C; Kärre K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1992;36(4):631
IS MHC CLASS-I BOUND PEPTIDE INVOLVED IN F(1)-HYBRID RESISTANCE
HOGLUND P; LJUNGGREN HG
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1992;36(4):628
MHC CLASS-I SPECIFIC AND RESTRICTED KILLING OF BETA-2M DEFICIENT CELLS BY CD8+ CYTOTOXIC LYMPHOCYTES-T
GLAS R; FRANKSSON L; OHLEN C; HOGLUND P; KOLLER B; LJUNGGREN HG; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1992;36(4):638
IDENTIFICATION OF H-2K(B), D(B) AND D(D) CLASS-I BINDING PEPTIDES DERIVED FROM AMINO-ACID-SEQUENCES OF THE POLYOMA-VIRUS T-ANTIGENS
REINHOLDSSONLJUNGGREN G; FRANKSSON L; DALIANIS T; LJUNGGREN HG
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1992;36(4):628
BIOCHEMICAL-CHARACTERIZATION OF MHC CLASS-I HEAVY-CHAINS AND THEIR INTERACTION WITH EXOGENOUS PEPTIDE ON THE CELL-SURFACE OF BETA-2M DEFICIENT CELLS
GLAS R; ZHOU X; FERM M; BARBER B; KARRE K; JONDAL M; LJUNGGREN HG
Conference publication: BIOLOGIA FUTURA. 1991;42(1-3):213-229
ANTIGEN PRESENTATION AND THE ASSOCIATION OF CLASS-I MOLECULES
ELLIOTT TJ; CERUNDOLO V; OHLEN C; LJUNGGREN HG; KARRE K; TOWNSEND A
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1990;32(4):403
A METHOD TO MEASURE MHC CLASS-I-PEPTIDE INTERACTIONS AT THE CELL-SURFACE
LJUNGGREN HG; FRANKSSON L; HOGLUND P; OHLEN C; TOWNSEND A; PLOEGH HL; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1990;32(4):403
TRANSFECTION OF BETA-2M RESTORES INTERFERON MEDIATED PROTECTION FROM NK CELL-LYSIS IN YAC-1 LYMPHOMA MUTANTS
LJUNGGREN HG; STURMHOFEL K; WOLPERT E; HAMMERLING GJ; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1990;32(4):403
ANALYSIS OF MHC CLASS I MOLECULES UTILIZING HIGH-RESOLUTION ONE-DIMENSIONAL ISOELECTRIC-FOCUSING .2. PRACTICAL APPLICATIONS
LJUNGGREN HG; OUDSHOORNSNOEK M; MASUCCI MG; OHLEN C; KARRE K; PLOEGH HL
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1990;32(4):403
EMPTY MHC CLASS-I MOLECULES COME OUT IN THE COLD
LJUNGGREN HG; STAM N; OHLEN C; NEEFJES JJ; HOGLUND P; HEEMELS MT; BASTIN J; SCHUMACHER T; TOWNSEND A; KARRE K; PLOEGH HL
Book chapter: TRANSGENIC MICE AND MUTANTS IN MHC RESEARCH. 1990;p. 282-284
Transgene Induced MHC Mismatch Results in Rapid Natural Killer Cell Dependent Elimination of Lymphoma Cells
Höglund P; Ljunggren HG; Öhlén C; Kärre K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1990;32(4):423
ALLOSPECIFIC CTL CLONES THAT RECOGNIZE MUTANT-CELLS FAILING TO PROCESS INTERNALLY DERIVED ANTIGENS
OHLEN C; LJUNGGREN HG; HOGLUND P; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1989;30(5):637
RESISTANCE TO H-2B LYMPHOMA IN H-2DD TRANSGENIC C57B1 MICE OCCURS THROUGH RAPID NK-MEDIATED REJECTION OF TUMOR-CELLS AND CAN BE REVERSED BY TRANSFECTION OF THE H-2DD GENE TO THE TARGET
HOGLUND P; LJUNGGREN HG; OHLEN C; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1989;30(5):644
MHC CLASS-I EXPRESSION IN TRANSPLANTATION TOLERANCE AND PEPTIDE PRESENTATION TO CTL - A MUTANT-CELL THAT FAILS TO PRESENT INTERNALLY DERIVED H-2 RESTRICTED ANTIGENS BUT REMAINS SENSITIVE TO ALLO H-2 SPECIFIC RESPONSES
OHLEN C; LJUNGGREN HG; FOSTER L; WOLPERT E; TOWNSEND A; KARRE K
Conference publication: JOURNAL OF NEURO-ONCOLOGY. 1987;5(2):187
EXPRESSION OF HISTOCOMPATIBILITY ANTIGENS AND MALIGNANCY OF TUMORS TRANSPLANTED WITHIN THE BRAIN
YAMASAKI T; KARRE K; LJUNGGREN HG; HOGLUND P; ANDERSSON M; PETERSSON MGE; COLLINS P; KLEIN G
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1987;26(3):335
DIMETYL SULFOXID (DMSO) INDUCES EXPRESSION OF H-2 ON THE MURINE LYMPHOMA CELL-LINE YAC-1 IN PARALLELL WITH INCREASED T-CELL AND DECREASED NK CELL SUSCEPTIBILITY
YAMASAKI T; LJUNGGREN HG; HOGLUND P; OHLEN C; PETERSSON M; KLEIN G; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1987;26(3):319
SELECTIVE ACCEPTANCE OF MHC CLASS-I DEFICIENT TUMOR GRAFTS IN THE BRAIN
LJUNGGREN HG; YAMASAKI T; COLLINS VP; KLEIN G; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1987;26(3):324
LOSS OF HLA EXPRESSION IN VARIANTS OF AN EBV TRANSFORMED LYMPHBLASTOID CELL-LINE - CONSEQUENCES FOR THE SENSITIVITY TO CYTOTOXIC EFFECTOR-CELLS ACTIVATED BY ANTIGEN, INTERFERON OR IL-2
OHLEN C; BEJERANO MT; GRONBERG A; TORSTEINSDOTTIR S; FRANKSSON L; LJUNGGREN HG; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1986;24(4):466
MOLECULAR AND IMMUNOLOGICAL ANALYSIS OF MHC CLASS-I VARIANT TUMOR LINES
KARRE K; LJUNGGREN HG; COCHET M; KOURILSKY P; KIESSLING R; PAABO S; PIONTEK G; KLING G
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1986;24(4):470
AFFERENT AND EFFERENT INTERACTIONS IN THE NATURAL IMMUNITY DIRECTED SELECTIVELY AGAINST H-2 DEFICIENT TUMOR VARIANTS
LJUNGGREN HG; OHLEN C; HOGLUND P; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1986;24(4):466
HOW DO QUANTITATIVE CHANGES IN MHC EXPRESSION OF POTENTIAL TARGET-CELLS AFFECT THE INDUCTION AND EFFECTOR FUNCTION OF T-CELLS
KARRE K; OHLEN C; LJUNGGREN HG
Conference publication: IMMUNOBIOLOGY. 1984;167(1-3):43-44
ACTIVATION OF CELL-MEDIATED-IMMUNITY BY ABSENCE OR DELETED EXPRESSION OF NORMAL CELLULAR GENE-PRODUCTS, IE BY NO SELF RATHER THAN NON SELF
KARRE K; LJUNGGREN HG; PIONTEK G; KIESSLING R; KLEIN G; TANIGUCHI K; GRONBERG A
Conference publication: IMMUNOBIOLOGY. 1984;167(1-3):189
INVIVO ELIMINATION OF A LYMPHOMA VARIANT WITH REDUCED EXPRESSION OF MHC GENE-PRODUCTS MEDIATED BY NATURAL-KILLER CELLS
LJUNGGREN HG; KARRE K
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1984;20(2):177
NATURAL-KILLER CELLS ARE RESPONSIBLE FOR INVIVO ELIMINATION OF LYMPHOMA VARIANTS WITH REDUCED EXPRESSION OF MHC GENES
LJUNGGREN HG; KARRE K
Conference publication: IMMUNOBIOLOGY. 1984;167(1-3):191-192
NATURAL CELL-MEDIATED-IMMUNITY AGAINST MHC CLASS-I VARIANTS OF THE NK-SENSITIVE YAC-1 T-LYMPHOMA
PIONTEK GE; TANIGUCHI K; LJUNGGREN HG; GRONBERG A; KIESSLING R; KARRE K
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Grants

NextGenNK - Competence Center for Next-generation NK Cell-based Cancer Immunotherapy
VINNOVA
15 November 2024 - 31 December 2029
Immunologic and virological correlates of long COVID: A bedside to bench approach
Swedish Research Council
1 December 2021 - 30 November 2025
Covid-19 vaccination in immunocompromised individuals: An interdisciplinary framework to gain clinical and mechanistic insight into durable immunity to SARS-CoV-2 infection
Swedish Research Council
1 June 2021 - 31 May 2025
Development of novel NK cell-based immunotherapies for treatment of human hematological malignancies
Swedish Research Council
1 January 2021 - 31 December 2023
Ljunggren, Hans-Gustaf – Continued development and implementation of novel NK cell-based immunotherapies for treatment of human hematological malignancies
Swedish Cancer Society
1 January 2021
Competence Center for Next-generation NK Cell-based Cancer Immunotherapy (NextGenNK)
VINNOVA
1 January 2020 - 31 December 2024
Impoved global vaccination strategies for severe infectious diseases
VINNOVA
15 April 2018 - 31 December 2018
NK cell-based immunotherapy for patients with incurable hematological cancer
Swedish Cancer Society
1 January 2018
Molecular dynamics of T cell exhaustion in human viral infection and cancer affecting immune recovery and health
Swedish Research Council
1 January 2018 - 31 December 2020
NK cell-based immunotherapy for patients with incurable hematological cancer
Swedish Cancer Society
1 January 2017
Role of NK cells in driving disease-development following infections with hantaviruses: Development of new targeted interventions
Swedish Research Council
1 January 2016 - 31 December 2019
Treatment of blood cancer with NK (natural killer) cells
Swedish Cancer Society
1 January 2016
Treatment of blood cancer with NK (natural killer) cells
Swedish Cancer Society
1 January 2015
Treatment of blood cancer with NK (natural killer) cells
Swedish Cancer Society
1 January 2014
Treatment strategy for severe human hantavirus infection
Swedish Foundation for Strategic Research
1 August 2013 - 31 July 2018
Molecular pathogenesis and treatment strategy for severe hantavirus-infection
Swedish Research Council
1 January 2013 - 31 December 2016
2011 NK Cell Workshop - KIR: A New Immunogenetic System with Influence on Human Disease
Swedish Research Council
1 January 2011 - 31 December 2011
Human NK cells: Differentiation, viral infection, and primary immunodeficiencies
Swedish Research Council
1 January 2011 - 31 December 2015
"The Immune System in Health and Diseases"
Swedish Research Council
1 July 2008 - 31 December 2008
New web page for CIM
Swedish Foundation for Strategic Research
1 January 2008 - 31 December 2008
Ansökan om bidrag till konferens inom infektionsmedicinsk forskning samt till presentationsskrift
Swedish Foundation for Strategic Research
1 January 2008 - 31 December 2008
GRK 1273: Strategies of Human Pathogens to Establish Acute and Chronic Infections
Deutsche Forschungsgemeinschaft
1 January 2006 - 31 December 2015
Immunological, Cell Biological, and Biochemical Studies of HAM-1 Knock-Out Mice
Council for International Exchange of Scholars
1 September 1991 - 31 August 1992
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Employments

Professor/Senior Physician, Department of Medicine, Huddinge, Karolinska Institutet, 2001-

Degrees and Education

University Medical Degree, Karolinska Institutet, 1992

About me

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